AUTHOR=Doulidis Pavlos G. , Frizzo-Ramos Carolina , Bertram Christof A. , Grünzweil Olivia M. , Kneissl Sibylle M. , Degasperi Brigitte , Hirt Reinhard A. , Burgener Iwan A. , Luckschander-Zeller Nicole 

TITLE=Case Report: α1-antitrypsin deficiency causing persistent pleural effusion and multilobar alveolar emphysema in a young dog

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1678702

DOI=10.3389/fvets.2025.1678702

ISSN=2297-1769

ABSTRACT=Alpha-1 antitrypsin deficiency (A1ATD) is a rare genetic condition in both humans and animals, caused by mutations in the SERPINA1 gene that lead to reduced or absent production of alpha-1 antitrypsin (A1AT). This case report describes a 3-year-old male dog presenting with persistent pleural effusion, chronic nonproductive cough, and respiratory distress. Despite an extensive diagnostic evaluation that included computed tomography (CT), a definitive diagnosis of A1ATD was only reached after a histopathological examination of lung tissue, which revealed acinar emphysema characterized by the destruction of alveolar walls. Serum A1AT levels were undetectable, confirming the diagnosis. The absence of liver involvement aligned with the lung-predominant phenotype described in human A1ATD. This is the first reported case of A1ATD-associated emphysema and pleural effusion in a dog, emphasizing the need for further research into its pathophysiology, diagnosis, and management in canine patients.