AUTHOR=Swindell Madeleine , Bolton Timothy A. , Powers Cassandra M. , Novotny Ladislav , Jarvis Jack , Murakami Masahiro 

TITLE=Osteolytic metastases from a pheochromocytoma presenting as multiple limb lameness and joint swelling in a dog: a case report

JOURNAL=Frontiers in Veterinary Science

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1585969

DOI=10.3389/fvets.2025.1585969

ISSN=2297-1769

ABSTRACT=Clinical signs due to distant bony metastasis from a malignant pheochromocytoma are rare in dogs, with the majority of reported cases presenting as single-limb lameness. This case report describes a 6-year-old neutered male mixed-breed dog presenting with multiple limb lameness and joint swelling that occurred over 3 weeks. Computed tomography revealed a mass in the right adrenal gland with extensive intrathoracic, intra-abdominal, and skeletal metastases. Because of the poor prognosis, the dog was humanely euthanized. A postmortem examination revealed a primary neoplasm of the right adrenal gland with metastases affecting the contralateral adrenal gland, kidneys, lungs, liver, and bones of the appendicular and axial skeletons. Immunohistochemistry confirmed a metastatic neuroendocrine carcinoma of the right adrenal gland, consistent with a pheochromocytoma. This case is a unique presentation of polyostotic metastases from a pheochromocytoma and emphasizes the importance of including this tumor in the differential diagnosis of dogs presenting with symptoms identical to those of polyarthritis.