Front. Vet. Sci. Frontiers in Veterinary Science Front. Vet. Sci. 2297-1769 Frontiers Media S.A. 10.3389/fvets.2023.1130466 Veterinary Science Correction Corrigendum: Acute and subacute toxicity assessment of oxyclozanide in Wistar rats Wang Weiwei 1 2 3 Dong Zhen 1 2 3 Zhang Jili 1 2 3 Zhou Xuzheng 1 2 3 Wei Xiaojuan 1 2 3 Cheng Fusheng 1 2 3 Li Bing 1 2 3 Zhang Jiyu 1 2 3 * 1Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China 2Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China 3Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China

Edited and reviewed by: Arturo Anadón, Complutense University of Madrid, Spain

 *Correspondence: Jiyu Zhang ✉ infzjy@sina.com

This article was submitted to Veterinary Pharmacology and Toxicology, a section of the journal Frontiers in Veterinary Science

 01 02 2023 2023 10 1130466 23 12 2022 13 01 2023 Copyright © 2023 Wang, Dong, Zhang, Zhou, Wei, Cheng, Li and Zhang. 2023 Wang, Dong, Zhang, Zhou, Wei, Cheng, Li and Zhang

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 A corrigendum on Acute and subacute toxicity assessment of oxyclozanide in Wistar rats by Wang, W., Dong, Z., Zhang, J., Zhou. X., Wei, X., Cheng, F., Li, B., and Zhang, J. (2019). Front. Vet. Sci. 6:294. doi: 10.3389/fvets.2019.00294 oxyclozanide acute subacute toxicity rats

In the published article Reference Manual of Laboratory Animal Blood Physiology and Biochemistry (book) was not cited in the article. The citation has now been inserted in Tables 2, 3, [Historical controls range] and should read:

Haematological values of rats in oxyclozanide-treated group and control group.

Historical controls range (45) Oxyclozanide doses (mg/kg)
0 mg/kg (control) 74 mg/kg (low-dose) 185 mg/kg (medium-dose) 370 mg/kg (high-dose)
Male
WBC (× 109·L−1) 4–6 5.28 ± 2.12 4.00 ± 1.73 5.47 ± 2.44 5.13 ± 1.22
LYM (× 109·L−1) 2–5 2.87 ± 1.70 3.50 ± 1.22 4.10 ± 2.01 3.88 ± 0.96
Mon (× 109·L−1) 0.05–0.10 0.05 ± 0.071 0.06 ± 0.074 0.08 ± 0.071 0.08 ± 0.044
Gran (× 109·L−1) 0.5–1.0 0.54 ± 0.46 0.63 ± 0.43 0.80 ± 0.48 0.98 ± 0.48
RBC (× 1012·L−1) 6–8 7.04 ± 0.38 7.29 ± 0.51 7.03 ± 0.48 6.93 ± 0.45
HGB (g·L −1) 120–140 137.55 ± 5.47 128.60 ± 22.83 135.38 ± 10.21 136.17 ± 10.53
HCT 35–45 41.57 ± 1.50 43.14 ± 3.10 41.26 ± 3.02 41.18 ± 3.11
MCV (fL) 55–65 59.16 ± 1.91 59.24 ± 0.97 58.75 ± 1.88 59.47 ± 2.32
MCH (pg) 17–21 19.51 ± 0.48 17.37 ± 3.01** 19.18 ± 0.46 19.58 ± 0.67
MCHC (g·L−1) 270–340 330.36 ± 4.39 293.67 ± 50.54 327.50 ± 7.44 330.17 ± 7.98
RDW 10–15 11.60 ± 2.21 10.84 ± 1.69 12.75 ± 1.84 12.60 ± 1.81
PLT (× 109·L−1) 800–1,000 860.18 ± 153.11 939.44 ± 154.04 956.38 ± 68.66 759.40 ± 144.87
MPV (fL) 5–7 6.38 ± 0.25 6.28 ± 0.31 6.09 ± 0.50 5.95 ± 0.66
PDW 15–17 16.19 ± 0.18 16.29 ± 0.32 16.13 ± 0.25 16.22 ± 0.43
PCT (ng·L−1) 0.4–0.8 0.53 ± 0.079 0.56 ± 0.073 0.58 ± 0.052 0.58 ± 0.090
Female
WBC (× 109·L−1) 4–6 4.14 ± 2.16 5.76 ± 1.63 4.66 ± 1.98 5.01 ± 1.36
LYM (× 109·L−1) 3–5 3.46 ± 1.55 4.64 ± 0.612 4.25 ± 1.09 4.11 ± 1.14
Mon (× 109·L−1) 0.05–0.10 0.09 ± 0.074 0.10 ± 0.076 0.08 ± 0.067 0.06 ± 0.052
Gran (× 109·L−1) 0.6–1.1 0.86 ± 0.45 0.90 ± 0.41 1.00 ± 0.42 0.92 ± 0.20
RBC (× 1012·L−1) 6–8 7.45 ± 0.21 7.21 ± 1.31 7.26 ± 1.47 7.23 ± 0.35
HGB (g·L−1) 120–140 148.45 ± 7.85 126.38 ± 28.23 136.80 ± 38.84 143.88 ± 6.94
HCT 35–45 44.50 ± 1.22 42.80 ± 7.84 42.99 ± 8.63 43.70 ± 2.07
MCV (fL) 60 ± 6 59.86 ± 1.73 53.05 ± 19.12 59.30 ± 1.00 60.55 ± 2.37
MCH (pg) 17–21 19.89 ± 0.81 17.53 ± 2.35* 18.44 ± 3.49 19.88 ± 0.69
MCHC (g·L−1) 270–340 333.00 ± 15.50 296.13 ± 41.19* 311.78 ± 58.95 328.88 ± 4.12
RDW 10–15 14.92 ± 0.45 13.80 ± 1.16** 14.78 ± 0.55 14.41 ± 0.77
PLT (× 109·L−1) 900–1,100 1,015.82 ± 91.63 970.38 ± 215.43 921.38 ± 192.32 953.33 ± 155.58
MPV (fL) 5–7 6.25 ± 0.22 6.33 ± 0.26 6.46 ± 0.69 6.18 ± 0.37
PDW 15–17 16.07 ± 0.13 16.13 ± 0.18 16.50 ± 1.15 16.10 ± 0.41
PCT (ng·L−1) 0.4–0.8 0.63 ± 0.056 0.55 ± 0.132* 0.49 ± 0.174 0.50 ± 0.197

p < 0.05 vs. control group.

p < 0.01 vs. control group.

Liver function related to biochemical profiles.

Historical controls range (45) Oxyclozanide doses
0 mg/kg (Control) 74 mg/kg (Low-dose) 185 mg/kg (Medium-dose) 370 mg/kg (High-dose)
Male
TBIL (μmol·L−1) 0.3–0.7 0.52 ± 0.23 0.54 ± 0.29 0.39 ± 0.19 0.35 ± 0.17
DBIL (μmol·L−1) 0.8–1.4 1.20 ± 0.55 0.97 ± 0.32 1.01 ± 0.22 1.32 ± 0.51
TP (g·L−1) 30–50 41.94 ± 15.15 36.17 ± 11.22 41.83 ± 9.38 49.97 ± 8.13
ALB (g·L−1) 18–26 19.45 ± 6.61 18.30 ± 5.53 19.63 ± 4.04 24.36 ± 3.48*
GLO (g·L−1) 16–26 22.45 ± 8.63 17.87 ± 5.73 22.20 ± 5.57 25.62 ± 4.90
ALT (U·L−1) 25–35 34.88 ± 12.47 27.35 ± 9.97 34.62 ± 9.68 32.45 ± 5.23
AST (U·L−1) 95–150 98.43 ± 33.86 132.14 ± 35.72 158.11 ± 48.63** 199.45 ± 32.55**
ALP (U·L−1) 120–200 131.71 ± 25.22 135.00 ± 26.93 197.00 ± 46.29* 224.00 ± 81.28**
TG (mmol·L−1 0.5–.07 0.62 ± 0.18 0.63 ± 0.17 0.68 ± 0.33 0.56 ± 0.16
TC (mmol·L−1 1.0–2.0 1.52 ± 0.47 1.34 ± 0.45 1.70 ± 0.36 1.70 ± 0.36
GLU (mmol·L−1) 4–8 6.64 ± 1.50 6.00 ± 1.15 5.49 ± 1.45 4.95 ± 1.09**
BUN (mmol·L−1) 5–9 5.49 ± 1.34 7.01 ± 1.98 7.17 ± 1.33 8.76 ± 2.99**
CR (μmol·L−1) 20–30 24.89 ± 17.67 21.05 ± 7.06 25.22 ± 5.19 29.46 ± 8.73
UA (μmol·L−1) 0.04–0.06 0.046 ± 0.012 0.045 ± 0.017 0.065 ± 0.021 0.080 ± 0.048*
LDH (U·L−1) 1,200–2,000 1,320.30 ± 469.50 1,582.11 ± 303.31 1,864.00 ± 433.37** 1,954.77 ± 236.24**
CK (U·L−1) 1,100–1,700 1,188.72 ± 488.39 1,210.48 ± 279.84 1,499.38 ± 405.02 1,628.94 ± 312.20**
Female
TBIL (μmol·L−1) 0.4–0.8 0.69 ± 0.27 0.45 ± 0.26* 0.49 ± 0.14 0.27 ± 0.12**
DBIL (μmol·L−1) 1–2 1.32 ± 0.42 1.27 ± 0.47 1.46 ± 0.49 1.48 ± 0.43
TP (g·L−1) 40–48 45.85 ± 9.98 42.24 ± 10.40 45.40 ± 13.24 40.32 ± 4.21
ALB (g·L−1) 20–26 23.33 ± 4.65 21.60 ± 5.10 22.49 ± 6.09 25.87 ± 3.98
GLO (g·L−1) 20–30 22.52 ± 5.34 20.65 ± 5.36 22.91 ± 7.30 28.97 ± 6.49**
ALT (U·L−1) 25–35 26.11 ± 7.17 25.64 ± 10.56 30.68 ± 11.99 33.92 ± 6.11
AST (U·L−1) 130–180 137.10 ± 31.18 155.70 ± 39.79 177.71 ± 49.51* 206.60 ± 25.16**
ALP (U·L−1) 90–140 97.82 ± 31.68 122.00 ± 30.99 146.17 ± 23.81** 190.67 ± 21.56**
TG (mmol·L−1) 0.5–1.0 0.76 ± 0.25 0.56 ± 0.14* 0.54 ± 0.17* 0.45 ± 0.06**
TC (mmol·L−1) 1.0–2.0 1.54 ± 0.29 1.59 ± 0.35 1.64 ± 0.43 1.73 ± 0.22
GLU (mmol·L−1) 4–8 5.73 ± 1.33 5.59 ± 0.68 5.86 ± 2.01 4.62 ± 0.61
BUN (mmol·L−1) 5–10 5.75 ± 2.14 8.30 ± 1.94** 7.95 ± 1.58* 9.63 ± 1.59**
CR (μmol·L−1) 25–30 27.02 ± 6.23 25.96 ± 6.94 26.28 ± 6.42 28.80 ± 5.45
UA (μmol·L−1) 0.05–0.07 0.061 ± 0.016 0.056 ± 0.011 0.071 ± 0.034 0.063 ± 0.020
LDH (U·L−1) 1,200–1,800 1,605.75 ± 278.48 1,802.50 ± 342.99 1,840.88 ± 343.80 1,895.00 ± 195.69
CK (U·L−1) 1,100–1,700 1,306.00 ± 309.40 1,547.52 ± 369.63 1,595.46 ± 323.62 1,503.43 ± 192.21

p < 0.01 vs. control group.

p < 0.05 vs. control group.

“[Historical controls range (45)]”

45. Wang D, Zeng L, Shang S. Reference Manual of Laboratory Animal Blood Physiology and Biochemistry. Science Publishing (2011).

In the published article, there was an error in Table 2 as published. The units for the hematological parameters used in Table 2 were missing. The corrected Table 2 and its caption **Hematological values of rats in the oxyclozanide-treated group and the control group appear below.

In the published article, there was an error in Table 3 as published. The units for the biochemical parameters used in Table 3 were missing. The corrected Table 3 and its caption **Liver function related to biochemical profiles appear below.

In the published article, Supplementary Appendix 1 was mistakenly not included in the publication. The missing material appears below:

The blood samples collected in the EDTAK2-coated tubes were analyzed using Mindray BC-2800 Vet Automatic blood analyser (MINDRAY Medical International Co., Ltd). Erba XL-640 Automatic biochemical analyser (Erba Mannheim Co., Ltd.) was used for biochemical examination.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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