AUTHOR=Yang Chengliang , Shannon Casey P. , Zhao Hedi , Tebbutt Scott J. 

TITLE=Donor-specific graft injury in solid organ transplantation: potential mechanisms and therapeutic strategies

JOURNAL=Frontiers in Transplantation

VOLUME=Volume 3 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2024.1427106

DOI=10.3389/frtra.2024.1427106

ISSN=2813-2440

ABSTRACT=Organ transplantation is the most effective therapy for end-stage disease patients. In addition to organ donation after brain death (DBD), which is common in clinical practice, organ donation after circulatory death (DCD) is one of the solutions to the growing demand for transplanted organs. In this paper, we discuss insights gained from comparing DBD and DCD allografts. These comparisons suggest that  different types of donors may lead to different patterns of graft dysfunction and recovery in recipients, requiring different evidence-based therapies due to donor-specific injury.