AUTHOR=Pérez del Valle Katia M. , Moran Magro María , Gaitán Tocora Daniel , Boldoba Nerea Begoña , Benito Puncel Carmen , Silva Obregón Alberto , Rodríguez Palomares José R. , de Arriba de la Fuente Gabriel 

TITLE=Medium cut-off membrane expanded hemodialysis for Lithium removal: a case report

JOURNAL=Frontiers in Toxicology

VOLUME=Volume 7 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2025.1677299

DOI=10.3389/ftox.2025.1677299

ISSN=2673-3080

ABSTRACT=BackgroundLithium remains a first-line treatment for bipolar disorder, though its narrow therapeutic window poses a significant risk of toxicity. Severe intoxication can lead to neurologic, renal, gastrointestinal, and endocrine complications. Extracorporeal therapies are the mainstay in managing life-threatening cases, particularly when serum concentration exceed 4.0 mmol/L or when renal function is impaired. Intermittent hemodialysis (HD) is the recommended extracorporeal treatment due to lithium’s low molecular weight and minimal protein binding. Expanded hemodialysis (HDx) with medium cut-off (MCO) membranes, designed to enhance solute clearance, may represent a promising alternative.Case ReportWe present a case of acute lithium intoxication in a 48-year-old male with a history of recurrent suicidal behavior and chronic lithium therapy. The patient arrived at the emergency department in a deep coma (GCS 3), with a serum lithium concentration of 4.5 mmol/L and preserved renal function. He underwent two intermittent HDx sessions using a Theranova® TH-400 MCO membrane. Serum lithium concentration declined to 1.6 mmol/L after the first session and progressively to 0.1 mmol/L within 72 h. No treatment-related complications were observed.ConclusionThis case described the potential utility of HDx with the MCO membrane (Theranova® 400) in managing severe lithium poisoning, achieving effective and sustained drug clearance. While HDx-MCO may offer a viable alternative to conventional HD, especially in settings where enhanced solute removal is desirable, further studies are needed to determine its efficacy and clinical role in lithium toxicity management.