AUTHOR=Rosolowski Jessica , Weber Tilo , Malakpour-Permlid Atena , Oredsson Stina TITLE=Revisiting 3Rs: rethinking replacement and new approach methodologies JOURNAL=Frontiers in Toxicology VOLUME=Volume 7 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2025.1664209 DOI=10.3389/ftox.2025.1664209 ISSN=2673-3080