AUTHOR=Jerath Ravinder , Malani Varsha 
  
TITLE=The fading self in space-disruption of default spatial representation across neurological disorders
  
JOURNAL=Frontiers in Systems Neuroscience
  
VOLUME=Volume 19 - 2025
  
YEAR=2025
  
URL=https://www.frontiersin.org/journals/systems-neuroscience/articles/10.3389/fnsys.2025.1655500
  
DOI=10.3389/fnsys.2025.1655500
  
ISSN=1662-5137
  
ABSTRACT=Neurological disorders stem from an intermingled change to self-in-space. While many of these disorders present as spatial deficits—contralateral neglect syndrome, for example—they manifest from the same etiology: disruption to the brain’s “default spatial representation” (DSR). DSR is a basic internally generated representation of space that delineates where the self is located in space—without attentional focus from an external drive. We review how pathologic disintegration of DSR is associated with anomalous activation and connectivity within distinct large-scale brain networks (e.g., the default mode network and a comprehensive attention-networked system), leading to a heterogeneous presentation of clinically assessed outcomes. The outcomes include psychogenic paralysis of limbs, left-side neglect, rectified sense of other locations, disorders of consciousness, symptoms related to autism spectrum disorder, Alzheimer’s disease, schizophrenia, and depersonalization/derealization disorder. By consolidating evidence from neuroimaging, lesion-symptom mapping, and computational assessment, we aim to reconceptualize these disorders not as separate and independent maladies, but as manifestations of a deeper, shared etiology, supporting a network-based assessment strategy for diagnosis and treatment that seeks to restore self-in-space.