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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Sustain. Cities</journal-id>
<journal-title>Frontiers in Sustainable Cities</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Sustain. Cities</abbrev-journal-title>
<issn pub-type="epub">2624-9634</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/frsc.2023.1137641</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Sustainable Cities</subject>
<subj-group>
<subject>Perspective</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>From social and natural vulnerability to human-centered climate resilient coastal cities</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Niamir</surname> <given-names>Leila</given-names></name>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/2103828/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Pachauri</surname> <given-names>Shonali</given-names></name>
<uri xlink:href="http://loop.frontiersin.org/people/91315/overview"/>
</contrib>
</contrib-group>
<aff><institution>Energy, Climate, and Environment (ECE) Research Program, International Institute for Applied Systems Analysis (IIASA)</institution>, <addr-line>Laxenburg</addr-line>, <country>Austria</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Felix Dodds, University of North Carolina at Chapel Hill, United States</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Haimeng Liu, CAS, China</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Leila Niamir <email>niamir&#x00040;iiasa.ac.at</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Climate Change and Cities, a section of the journal Frontiers in Sustainable Cities</p></fn></author-notes>
<pub-date pub-type="epub">
<day>03</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>5</volume>
<elocation-id>1137641</elocation-id>
<history>
<date date-type="received">
<day>04</day>
<month>01</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>13</day>
<month>02</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2023 Niamir and Pachauri.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Niamir and Pachauri</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license></permissions>
<abstract>
<p>Anthropogenic climate change is increasingly affecting every city in the world, including through more intense weather and climate extremes. Climate impacts and risks are magnified in cities, which are home to more than half the world&#x00027;s population. Projections show one billion people will live in areas at risk of coastal hazards by 2050. Sea level rise jeopardizes cities to complicated wind, water, and coastal hazards. Potential impacts on wellbeing include damage to housing, transportation, and energy infrastructure as well as human health. Yet, attention thus far has focused on incremental adaptation responses, with a focus more on infrastructure and technology transitions in coastal cities. Comprehensive transformative actions that specifically incorporate behavioral, cultural and institutional options are largely neglected. In this perspective, we emphasize that immediate and massive effort and involvement from individuals to social entities across sectors, institutions, and systems is required for a transformation toward climate-resilient coastal cities. We conclude by emphasizing that dichotomies between ambitious adaptation and mitigation actions need to be bridged to enhance resilience to warming in coastal cities, and that this requires appropriate multi-level governance mechanisms to coordinate across agents and sectors.</p></abstract>
<kwd-group>
<kwd>climate change adaptation</kwd>
<kwd>climate change mitigation</kwd>
<kwd>multi-level governance</kwd>
<kwd>behavioral change</kwd>
<kwd>human wellbeing</kwd>
</kwd-group>
<contract-sponsor id="cn001">International Institute for Applied Systems Analysis<named-content content-type="fundref-id">10.13039/501100011859</named-content></contract-sponsor>
<counts>
<fig-count count="1"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="52"/>
<page-count count="6"/>
<word-count count="4824"/>
</counts>
</article-meta>
</front>
<body>
<sec id="s1">
<title>Social and natural vulnerability</title>
<p>From time immemorial, coastal cities have attracted large and growing concentrations of human populations. Today about 40% of the world&#x00027;s population lives in coastal cities (UNESCO, <xref ref-type="bibr" rid="B46">2011</xref>). It is also estimated that there are over 2,000 coastal city agglomerations with over 100,000 inhabitants (Barrag&#x000E1;n and de Andr&#x000E9;s, <xref ref-type="bibr" rid="B4">2015</xref>). While these cities offer vital livelihood, productive and employment opportunities, especially in marine and ocean-related activities, they are also increasingly vulnerable to complex hazards, both natural and anthropogenic. In recent decades, climate-related hazards, in particular, have accelerated in frequency and intensity (IPCC., <xref ref-type="bibr" rid="B22">2022</xref>). Consequently, populations in coastal cities are increasingly under threat, specifically socially vulnerable populations in these cities bear a disproportionately large proportion of losses from extreme events and have a lower capacity to recover and adapt (Berke et al., <xref ref-type="bibr" rid="B5">2019</xref>; Howell and Elliott, <xref ref-type="bibr" rid="B20">2019</xref>).</p>
<p>A characteristic common to coastal cities in the last decades has been rapid expansion that has accompanied general urbanization trends globally. This expansion has placed significant pressure on basic infrastructures, assets and essential services within these cities, particularly in the Global South. The vulnerability of populations in coastal cities in both the Global North and South is caused by a combination of hazard exposure, socioeconomic status, lack of adequate physical infrastructures, as well as limited institutional and governance capacity (Le, <xref ref-type="bibr" rid="B25">2020</xref>). High population densities, unplanned and <italic>ad hoc</italic> settlement expansion and large inequalities in access to decent living standards (Rao and Min, <xref ref-type="bibr" rid="B37">2018</xref>) are particular challenges for coastal cities in the Global South. A vast literature on assessing the causes, extent and consequences of coastal populations&#x00027; vulnerability has emerged in recent years (Filho et al., <xref ref-type="bibr" rid="B15">2019</xref>; Thomas et al., <xref ref-type="bibr" rid="B41">2019</xref>; Bukvic et al., <xref ref-type="bibr" rid="B9">2020</xref>; Rangel-Buitrago et al., <xref ref-type="bibr" rid="B36">2020</xref>). However, less is understood about opportunities for rapidly increasing these regions and populations&#x00027; resilience and adaptive capacity.</p>
<p>In the following, we provide a perspective on essential elements that need to be considered in an integrated way to enable a human-centered just, resilient and sustainable future for coastal city inhabitants. We illustrate the importance of these by means of selected examples from the literature showcasing best practices where and how such efforts have enabled a shift to more resilient planning and transformative adaptation in coastal cities. We then conclude by highlighting some research gaps and recommendations on important considerations to advance efforts to improve resilience and enhance the adaptability and sustainability of coastal cities.</p>
</sec>
<sec id="s2">
<title>Turning challenges into opportunities</title>
<p>Despite the many challenges faced by coastal cities, these cities offer huge opportunities to their inhabitants and can be centers of innovation and change to new and more sustainable ways of living. Cities consist of complex social systems of urban services, including housing, transport, food, health, jobs and energy, all of which are linked to ecosystem services. Thus, an integrated systems approach is needed to understand this complex system and its dynamics and feedbacks.</p>
<p>Several (urban) resilience studies have developed conceptual frameworks and identified key elements for accounting for such feedbacks (Folke, <xref ref-type="bibr" rid="B16">2006</xref>; Tyler and Moench, <xref ref-type="bibr" rid="B45">2012</xref>; Brown, <xref ref-type="bibr" rid="B7">2014</xref>; Torabi et al., <xref ref-type="bibr" rid="B43">2018</xref>; Meerow and Newell, <xref ref-type="bibr" rid="B27">2019</xref>). Research by Alberti et al. (<xref ref-type="bibr" rid="B1">2003</xref>), for example, proposes an integrated model to understand forces driving urban development patterns, how these patterns influence biophysical and human processes, and the resulting environmental changes and feedback on human and biophysical drivers. Three main elements that are consistently identified in several of the proposed frameworks include; (a) human system, (b) ecosystem and services, and (c) governance. Several studies examine the relationship between human and ecosystem/services and their impacts on human wellbeing. For example, there are studies that focus on the role of biodiversity and green spaces in cities (Ekkel and de Vries, <xref ref-type="bibr" rid="B14">2017</xref>; Aram et al., <xref ref-type="bibr" rid="B3">2019</xref>; Pati&#x000F1;o, <xref ref-type="bibr" rid="B34">2020</xref>; Anderson et al., <xref ref-type="bibr" rid="B2">2022</xref>), service provisioning and infrastructure (&#x0017D;lender and Ward Thompson, <xref ref-type="bibr" rid="B52">2017</xref>; Duy et al., <xref ref-type="bibr" rid="B13">2019</xref>; Miguez et al., <xref ref-type="bibr" rid="B28">2019</xref>; Sharifi, <xref ref-type="bibr" rid="B39">2022</xref>). Other studies focus on how social aspects (e.g., inequity) link to governance (Ziervogel and Taylor, <xref ref-type="bibr" rid="B51">2008</xref>; Berke et al., <xref ref-type="bibr" rid="B5">2019</xref>; Fraser, <xref ref-type="bibr" rid="B18">2022</xref>; Wu et al., <xref ref-type="bibr" rid="B49">2022</xref>). However, there is relatively little literature that takes a comprehensive view examining all three elements (human system, ecosystem and governance) together, and transformations that bridge the adaptation and mitigation divide are largely overlooked. Building on this insight, we distinguish between three layers of elements, namely agents, systems, and institutions, to characterize the dynamics of a transition to low-carbon, climate-resilient, high human wellbeing and just coastal cities. In the following, we discuss the importance of these in turn (see <xref ref-type="fig" rid="F1">Figure 1</xref>).</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p>Transition to a climate resilient city, an integrated systems approach.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="frsc-05-1137641-g0001.tif"/>
</fig>
<sec>
<title>Human: Agents of change</title>
<p>Actors can be (i) individuals and households whose personal decisions and actions (as consumers, prosumers, citizens) impact products/services/energy and resources; (ii) civil society, non-governmental organizations (NGOs), and social movements; and (iii) business firms, the financial sector, and professional organizations, who shape and incentivize technological and social innovation and the behavior of professional actors (Roy et al., <xref ref-type="bibr" rid="B38">2012</xref>; Creutzig et al., <xref ref-type="bibr" rid="B12">2022b</xref>). Transformation to climate-resilient cities requires a massive effort by all agents, from individuals to social entities.</p>
<p><bold>Individual</bold> differences in climate risk perception and motivation to change behavior suggest the need for segmentation in the way different individuals or groups are targeted in information or climate action campaigns, with age, education, political values, and personal experience being important segmentation variables. <bold>Collective action</bold> by individuals as part of formal social movements or informal lifestyle change can significantly impact climate mitigation and adaptation. Movements that shift social norms can produce tipping points toward new lifestyles (Niamir et al., <xref ref-type="bibr" rid="B30">2020</xref>; Otto et al., <xref ref-type="bibr" rid="B33">2020</xref>). <bold>Community initiatives</bold> involve collective action by civil society, typically local residents and community groups. Such initiatives can help with climate mitigation to improve energy efficiency, shifts to renewable energy and to reduce fuel poverty through collective ownership, benefit and control over decision-making. They are also important for climate adaptation to create opportunities for expanding existing skills among participants, e.g., leadership, finance, management as well as knowledge. In addition, communities of building managers, landlords, energy advisers, technology installers and car dealers influence patterns of mobility and shelter and the associated energy consumption by acting as <bold>middle actors</bold> in the provision of services. <bold>Business firms</bold>, financial markets, insurance agencies, and professionals and their organizations also have a role to play in climate change mitigation and adaptation and enhancing resilience. To achieve climate-resilient cities equitably, social change, addressing social practices and ways of organizing and challenging dominant norms and beliefs, is needed. Social innovation, whereby new combinations of social practices, which cope with human needs and problems better than existing practices, offers novel approaches to ecological crises that differ from traditional technology-based solutions and demonstrates the relevance of sustainable behavioral and lifestyle changes (Mont et al., <xref ref-type="bibr" rid="B29">2014</xref>; Pel et al., <xref ref-type="bibr" rid="B35">2020</xref>; Haskell et al., <xref ref-type="bibr" rid="B19">2021</xref>).</p>
<p>Examples in the literature that explore the role such actors have played in a transition to more climate-resilient coastal cities include an empirical investigation of variations in factors shaping households&#x00027; adaptations to flooding, the costliest hazard worldwide (Noll et al., <xref ref-type="bibr" rid="B31">2022</xref>). The authors of this work discuss how social influence, worry, climate change beliefs, self-efficacy, and perceived costs exhibit universal effects on household adaptations, despite contextual differences. Thus, they argue that to see prompt household adaptation behavior, personalized narratives should complement the communication of climate-driven risks. Other work has explored the potential of social innovation and its relation to individual behavioral change and governance to transform urban green spaces in Groningen and London (Spijker and Parra, <xref ref-type="bibr" rid="B40">2018</xref>). This study concluded that social innovations can have various positive impacts on the urban landscape and human wellbeing, empower people in their quest for new values in urban space, turn neglected spots into places with meaning, and connect the individual with the urban. Thus a transition to climate-resilient coastal cities requires a focus on multi-actor governance and collaboration, often with a focus on citizens and inclusion of grassroots initiatives, both through bottom-up and top-down processes and their combinations (see also the section on institutions).</p>
</sec>
<sec>
<title>Systems and services</title>
<sec>
<title>Urban planning and design</title>
<p>Among the many important components of urban design, green spaces are one way to significantly increase the resilience of cities to heatwaves, floods, landslides, and even coastal erosion while enhancing sustainability and human wellbeing by improving air quality, protecting biodiversity, and absorbing carbon (Ekkel and de Vries, <xref ref-type="bibr" rid="B14">2017</xref>; Creutzig et al., <xref ref-type="bibr" rid="B11">2022a</xref>). Sustainable Development Goal (SDG) 11 recognizes the importance of accessibility to urban green space for all population groups, regardless of income, gender, age, or ethnicity. The WHO also advocates for universal access to green space, and more specifically, that every urban dweller should live within 300 meters (linear distance) of green space or less than a 5-min walk. Living in or with easy access to green space can provide important mental and physical health benefits.</p>
<p>In many cities, however, public and green infrastructure is more abundant and accessible in high-income areas than in low-income areas, particularly in middle and low-income countries (Wolch et al., <xref ref-type="bibr" rid="B47">2014</xref>; Chen et al., <xref ref-type="bibr" rid="B10">2020</xref>; Pati&#x000F1;o, <xref ref-type="bibr" rid="B34">2020</xref>; Zepp et al., <xref ref-type="bibr" rid="B50">2020</xref>; Huang et al., <xref ref-type="bibr" rid="B21">2021</xref>). For example, in Cairo it is hard to find free public green space, and most parks are fenced and ticketed (Anderson et al., <xref ref-type="bibr" rid="B2">2022</xref>). Another study shows the proximity to urban green areas in European cities is comparatively low but increases toward the rural space. In other words, the median proximity to urban green is about 13 times larger than to non-urban green (Wolff et al., <xref ref-type="bibr" rid="B48">2020</xref>).</p>
<p><italic>Buildings&#x02014;</italic>as a shelter and a service provider- are crucial elements in the transition to a resilient city. Many bottom-up initiatives can be envisioned in the buildings sector, primarily rooted in sharing and circular economy; for example, participatory place-making and -keeping opportunities for marginalized groups, aiming for social integration, and community empowerment, and co-creating processes. Such initiatives also create opportunities from design for a more diverse society, that is to create new solidarities through housing and adaptable built environments that also contribute to the wellbeing of vulnerable citizens. Among the many ways to design for a more diverse and inclusive society and to create resilience and new solidarities through housing, the important role of cooperative projects, for example, social housing in Vienna, Helsinki, Amsterdam, and Copenhagen, is of particular relevance (Tsenkova, <xref ref-type="bibr" rid="B44">2021</xref>; Kadi and Lilius, <xref ref-type="bibr" rid="B23">2022</xref>; Kazepov and Verwiebe, <xref ref-type="bibr" rid="B24">2022</xref>).</p>
<p><italic>Transport infrastructure and choice architecture</italic> also serve as a frame in which mobility and other decisions happen. Changes in infrastructure provisioning can act as a <bold>nudge</bold> that makes people take different decisions by altering the decision-making procedure. In urban transport, some studies indicate that changes in infrastructure provision for active travel may contribute to the <bold>uptake</bold> of more walking and cycling (Frank et al., <xref ref-type="bibr" rid="B17">2019</xref>). Flooding incidents in cities worldwide have exposed the vulnerability of transport networks and the resulting significant, lasting disruption. This appears to be overlooked in emerging-coastal cities, especially prone to flooding, as plans for transport development are still largely being driven by economic considerations and uncontrolled urbanization (Duy et al., <xref ref-type="bibr" rid="B13">2019</xref>).</p>
</sec>
</sec>
<sec>
<title>Institutions</title>
<p>Climate change discloses fault lines of poverty, inequality, weak governance, and inadequate infrastructure. Conversely, studies show that inclusive governance and institutional capacity are key enablers for cities to adapt to and mitigate climate change. Policy contributes to shaping demand for services, travel and mobility, and given the range of activities, the policy agenda involves reaching out to a wide range of actors that includes practitioners and the general public. Therefore, a systematic deployment of effective regulatory and enforcement frameworks is required, which consists of regulations, market-based instruments, information-based instruments, and voluntary agreements at various governance levels to address a wide range of stakeholders and their concerns.</p>
<sec>
<title>Participatory governance</title>
<p>Transparent multilevel and inclusive governance, improved institutional capacity, access to affordable finance, and behavioral change are necessary enabling conditions for climate responses, risk reduction, and mitigation. Transformation to climate-resilient cities is enabled only when governments, civil society, and businesses, with the support of scientists, make development choices that prioritize risk reduction, equity, inclusion, and justice. For example, a study that explores a successful case for engaging disadvantaged populations in Seattle-USA, highlights how traditional neighborhood planning approaches were replaced by employing &#x0201C;trusted advocates&#x0201D; who serve as planning outreach liaisons that connect local government with people of color, immigrants, refugees, the elderly, and others. The liaisons are indigenous to different groups, trusted and respected. Research has found that the &#x0201C;trusted advocates&#x0201D; model offers promise in improving transparency of local government intentions, facilitating communication of information, and coevolving solutions that fit the needs of marginalized neighborhoods (Oshun et al., <xref ref-type="bibr" rid="B32">2011</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s3">
<title>Ways forward</title>
<p>Cities play an important role in climate change, biodiversity loss, human wellbeing, and the relationships between them. The preceding discussion highlights the essential elements required to realize human-centered climate-resilient development and the importance of the interconnection between the three elements of agents, systems and institutions. Coastal cities are highly integrated systems that amplify the interplay between urban and natural/climate systems. They are, therefore, particularly vulnerable but also provide significant opportunities to achieve multiple objectives when integrated approaches are taken. Keeping in mind that there is a need for more studies on coastal cities in the Global South, here we conclude with recommendations emerging from the literature discussed previously for two areas where such integration can prove to be particularly impactful.</p>
<sec>
<title>Overcoming mitigation-adaptation-resilience dichotomies</title>
<p>A growing literature recognizes the importance of aligning adaptation planning with overall city development and the significant potential co-benefits with climate mitigation actions (Thornbush et al., <xref ref-type="bibr" rid="B42">2013</xref>; Lee et al., <xref ref-type="bibr" rid="B26">2020</xref>; Boyd et al., <xref ref-type="bibr" rid="B6">2022</xref>). Yet, this research also reveals the considerable barriers to mainstreaming a focus on climate mitigation co-benefits in city adaptation, development, and resilience planning. There are, however, significant benefits to redesigning policies to harness synergies across actions adaptive to support current needs, that mitigate to avoid future adaptation needs, and build resilience by taking a proactive human-centered, longer time-horizon, and iterative learning systems perspective. Recent literature highlights successful coastal city cases, e.g., Durban, Cape Town, London, and Vancouver, where synergistic and strategic adaptation and mitigation planning could deliver near-term benefits (Boyd et al., <xref ref-type="bibr" rid="B6">2022</xref>). In addition, examples from research presented in the previous section (e.g., cooperative projects in Vienna, Helsinki, Amsterdam, and Copenhagen) showcase important ways in which this is being achieved and suggest that efforts to enhance such initiatives more widely would be worthwhile. In particular, to secure liveable and climate-resilient coastal cities, inclusive, equitable and actor-orientation in policies is needed. This includes individual and collective behavioral and lifestyle changes, political commitment, inclusive governance and integration across actors and sectors. Strengthening adaptation measures benefits vulnerable coastal cities and can reduce -but not eliminate all- losses and damages. At the same time, mitigation actions benefit from avoiding future damages and reduce future adaptation costs but entail higher up-front investment costs. Resilience planning strives to transform coastal cities and raise their ability to respond systemically and dynamically to present and future shocks and global challenges including unsustainable development patterns, rapid and <italic>ad hoc</italic> urbanization, climate change, and inequalities (Brunetta and Caldarice, <xref ref-type="bibr" rid="B8">2020</xref>). Forging synergies among adaptation, mitigation and resilience planning can benefit from actor-oriented approaches in addition to the traditional focus on infrastructures and technologies.</p>
</sec>
<sec>
<title>Multiscalar governance for cross-sectoral and cross-agent coordination</title>
<p>Much of the research discussed here emphasizes the critical role of the governance context for coastal cities. Addressing climate change and improving human wellbeing requires an inclusive, equitable and all-of-society approach. Studies show that national policies together with solid institutions&#x02014;which empower multi-scalar governance and local-level initiatives&#x02014;enable coastal cities to take action. Several governments have been investing in this system and strongly rely on their recommendation, namely, the London Climate Change Committee and the Trusted Advocates project in Seattle. The choices and actions we take now will have impacts for thousands of years. Multi-level governance and effective institutions can enable mitigation and adaptation strategies by prioritizing inclusive decision-making, enhancing equitable access to finance, infrastructure and technology, setting targets and priorities, and mainstreaming climate actions across sectors and actors. Immediate transitions across all sectors and systems that prioritize equity, social justice, and inclusion are needed to achieve mitigation and adaptation outcomes that shift pathways toward climate-resilient cities. While climate policy support is influenced by actors in civil society, business, youth, women, indigenous people, and local communities, policy effectiveness is enhanced by and requires political commitments, national and international partnerships, and cooperation.</p>
</sec>
</sec>
<sec sec-type="data-availability" id="s4">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="author-contributions" id="s5">
<title>Author contributions</title>
<p>Both authors contributed to the article and approved the submitted version.</p>
</sec>
</body>
<back>
<sec sec-type="funding-information" id="s6">
<title>Funding</title>
<p>Authors acknowledge the funding from the Energy Demand changes Induced by Technological and Social innovations (EDITS) project, coordinated by the Research Institute of Innovative Technology for the Earth (RITE) and International Institute for Applied Systems Analysis (IIASA) and funded by the Ministry of Economy, Trade, and Industry (METI), Japan.</p>
</sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s7">
<title>Publisher&#x00027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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