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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Surg.</journal-id>
<journal-title-group>
<journal-title>Frontiers in Surgery</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Surg.</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2296-875X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
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<article-meta>
<article-id pub-id-type="doi">10.3389/fsurg.2025.1613472</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Mini Review</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A perspective on arthroscopic treatment for anterior ankle impingement syndrome: clinical research insights</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Zong</surname><given-names>Long-Ze</given-names></name>
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<contrib contrib-type="author">
<name><surname>Feng</surname><given-names>Yong</given-names></name>
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<contrib contrib-type="author" corresp="yes">
<name><surname>Bai</surname><given-names>Dong-Yu</given-names></name>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref>
<uri xlink:href="https://loop.frontiersin.org/people/3039140/overview"/>
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<aff id="aff1"><institution>Department of Orthopedics, Affiliated Hospital of Yan&#x2018;an University</institution>, <city>Yan&#x0027;an</city>, <country country="cn">China</country></aff>
<author-notes>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Dong-Yu Bai <email xlink:href="mailto:dong-yubai@hotmail.com">dong-yubai@hotmail.com</email></corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-01-21"><day>21</day><month>01</month><year>2026</year></pub-date>
<pub-date publication-format="electronic" date-type="collection"><year>2025</year></pub-date>
<volume>12</volume><elocation-id>1613472</elocation-id>
<history>
<date date-type="received"><day>23</day><month>04</month><year>2025</year></date>
<date date-type="accepted"><day>08</day><month>07</month><year>2025</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2026 Zong, Feng and Bai.</copyright-statement>
<copyright-year>2026</copyright-year><copyright-holder>Zong, Feng and Bai</copyright-holder><license><ali:license_ref start_date="2026-01-21">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license>
</permissions>
<abstract><sec><title>Introduction</title>
<p>Anterior ankle impingement syndrome (AAIS) is a degenerative condition that causes anterior ankle pain and limited dorsiflexion, especially in athletes. It results from either osseous (osteophytes) or soft tissue (synovial hypertrophy, fibrosis) pathology.</p>
</sec><sec><title>Methods</title>
<p>Although conservative treatments offer temporary relief, arthroscopic surgery has become the preferred approach due to its minimally invasive technique and surgical precision.</p>
</sec><sec><title>Results</title>
<p>Current evidence shows 80&#x0025;&#x2013;90&#x0025; success rates, with significant improvements in visual analog scale scores (mean reduction of 4.1 points) and American orthopedic foot &#x0026; ankle society scores (mean increase of 28 points), along with low complication rates (2&#x0025;&#x2013;7&#x0025;). However, outcomes are closely linked to the severity of pre-existing osteoarthritis, with 93&#x0025; success in non-arthritic joints compared to 53&#x0025; in cases with moderate osteoarthritis. Key research limitations include heterogeneous study designs, small sample sizes, and a lack of long-term data (only 18.6&#x0025; of studies report &#x2265;5-year follow-up).</p>
</sec><sec><title>Discussion</title>
<p>Future research should focus on standardizing outcome measures, assessing the cost-effectiveness of advanced techniques, and establishing evidence-based protocols for patient selection and rehabilitation. These efforts will help optimize surgical decision-making and enhance long-term outcomes for patients with AAIS.</p>
</sec>
</abstract>
<kwd-group>
<kwd>anterior ankle impingement syndrome</kwd>
<kwd>arthroscopic treatment</kwd>
<kwd>ankle disorder</kwd>
<kwd>insight</kwd>
<kwd>perspective</kwd>
</kwd-group><funding-group>
<funding-statement>The author(s) declare that no financial support was received for the research and/or publication of this article.</funding-statement>
</funding-group>
<counts>
<fig-count count="1"/>
<table-count count="1"/><equation-count count="0"/><ref-count count="50"/><page-count count="8"/><word-count count="2154"/></counts><custom-meta-group><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>Orthopedic Surgery</meta-value></custom-meta></custom-meta-group>
</article-meta>
</front>
<body><sec id="s1" sec-type="intro"><label>1</label><title>Introduction</title>
<p>Anterior ankle impingement syndrome (AAIS) causes chronic ankle disorder characterized by anterior ankle pain and restricted dorsiflexion, primarily affecting athletes, dancers, and others performing repetitive high-impact ankle movements (<xref ref-type="bibr" rid="B1">1</xref>&#x2013;<xref ref-type="bibr" rid="B3">3</xref>). The condition arises from either bony impingement (e.g., tibial or talar osteophytes) or soft tissue impingement (e.g., synovial hypertrophy, thickened ligament, or fibrosis) (<xref ref-type="bibr" rid="B1">1</xref>&#x2013;<xref ref-type="bibr" rid="B3">3</xref>). Epidemiological data indicate that AAIS affects approximately 20&#x0025;&#x2013;40&#x0025; of soccer players and a higher proportion of ballet dancers, severely limiting mobility and quality of life (<xref ref-type="bibr" rid="B4">4</xref>).</p>
<p>Treatment options range from conservative therapies (e.g., physical therapy, non-steroidal anti-inflammatory drugs, corticosteroid injections) to open surgery (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B6">6</xref>). Although helpful for some, conservative management often fails with structural abnormalities (e.g., prominent osteophytes or ligamentous hypertrophy), leading to frequent symptom recurrence (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B6">6</xref>). While open surgery effectively treats pathological structures, it risks extensive tissue injury, slow recovery, scarring, and joint stiffness (<xref ref-type="bibr" rid="B7">7</xref>). Recently, arthroscopic techniques have become preferred in foot/ankle surgery (<xref ref-type="bibr" rid="B8">8</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>). Arthroscopy provides smaller incisions, better visualization, faster recovery, and precise debridement with less tissue injury than open surgery (<xref ref-type="bibr" rid="B8">8</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>).</p>
<p>Despite its benefits, arthroscopy&#x0027;s optimal use and long-term results remain debated (<xref ref-type="bibr" rid="B8">8</xref>&#x2013;<xref ref-type="bibr" rid="B11">11</xref>). Some report better outcomes for bony vs. soft tissue impingement, whereas others like recurrence to incomplete debridement or poor rehabilitation (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B11">11</xref>). Moreover, high-quality long-term data are lacking, preventing firm conclusions about durability (<xref ref-type="bibr" rid="B12">12</xref>).</p>
<p>Our perspective offers a focused examination of arthroscopic treatment for AAIS, integrating clinical experience with published findings to highlight key technical considerations, treatment outcomes, and associated complications. Drawing from both established data and current practice patterns, we identify critical areas where evidence remains limited while offering practical guidance for clinicians. This study aims to bridge the gap between existing research and real-world clinical application, presenting a balanced view of arthroscopic management for AAIS that may help refine treatment approaches and decision-making.</p>
</sec>
<sec id="s2"><label>2</label><title>Study retrieval and selection</title>
<p>We systematically searched four major medical databases (including PubMed, Embase, Cochrane Library, and Web of Science) for studies on arthroscopic AAIS treatment. The search used key terms such as &#x201C;anterior ankle impingement,&#x201D; &#x201C;ankle arthroscopy,&#x201D; and &#x201C;surgical treatment,&#x201D; without publication date or language restrictions. After duplicate removal, 346 unique records remained. Two authors independently screened titles/abstracts using predefined eligibility criteria: (1) clinical studies (prospective or retrospective designs); (2) patients with confirmed AAIS; (3) primary arthroscopic treatment; and (4) reported outcome measures such as pain scales, functional scores, complications, or recurrence rates. We excluded non-clinical studies, reviews, small case reports (&#x003C;10 patients), and duplicates. After screening, 322 records were excluded. All 24 remaining articles met inclusion criteria after full-text review and were analyzed (<xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref>).</p>
<fig id="F1" position="float"><label>Figure&#x00A0;1</label>
<caption><p>Flowchart of study selection.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="fsurg-12-1613472-g001.tif"><alt-text content-type="machine-generated">Flowchart of a study selection process. Identification from PubMed, Embase, Cochrane Library, and Web of Science resulted in 481 studies. After removing duplicates, 346 remained. Screening reduced these to 151 by excluding 195 irrelevant studies. Eligibility assessment left 65 studies by excluding 86 not specific to anterior ankle impingement syndrome or arthroscopic treatment. Finally, 24 studies were included, excluding 41 full-text studies for reasons such as lack of retrospective or prospective study design and small sample size.</alt-text>
</graphic>
</fig>
</sec>
<sec id="s3"><label>3</label><title>Pathophysiology and diagnosis of AAIS</title>
<sec id="s3a"><label>3.1</label><title>Etiology and classification</title>
<p>AAIS is an important clinical condition with distinct causes and diagnostic challenges (<xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B5">5</xref>&#x2013;<xref ref-type="bibr" rid="B7">7</xref>). Its pathophysiology includes two main types: osseous impingement (from tibial/alar osteophytes caused by repetitive microtrauma in athletes) and soft tissue impingement (featuring synovial proliferation, ligament thickening, or fibrosis) that typically follows ankle trauma (<xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B14">14</xref>).</p>
<p>Current classification systems offer important diagnostic guidance. The Scranton-McDermott system stages AAIS by osteophyte size and location, while the van Dijk classification focuses on soft tissue patterns that guide surgical decisions (<xref ref-type="bibr" rid="B15">15</xref>, <xref ref-type="bibr" rid="B16">16</xref>).</p>
</sec>
<sec id="s3b"><label>3.2</label><title>Clinical presentation and imaging evaluation</title>
<p>AAIS typically presents with anterior ankle pain worsened by dorsiflexion, tenderness, limited motion, and sometimes mechanical symptoms such as catching or locking (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B5">5</xref>&#x2013;<xref ref-type="bibr" rid="B9">9</xref>).</p>
<p>Diagnosis requires a multimodal approach beginning with weight-bearing radiographs for initial osteophyte assessment. When indicated, advanced imaging modalities provide additional value: magnetic resonance imaging (MRI) offers superior soft tissue resolution and detects early bone marrow changes; dynamic ultrasonography enables real-time functional assessment; and computed tomography (CT) reconstruction provides detailed osseous architecture evaluation (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B14">14</xref>).</p>
<p>Notably, approximately 15&#x0025;&#x2013;20&#x0025; of cases show clinically significant discordance between imaging findings and symptom severity, necessitating comprehensive clinical correlation and sometimes diagnostic injections for definitive pain source identification (<xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B14">14</xref>, <xref ref-type="bibr" rid="B17">17</xref>). This diagnostic approach emphasizes integrating clinical examination with targeted imaging to optimize accuracy and guide therapeutic interventions.</p>
</sec>
</sec>
<sec id="s4"><label>4</label><title>Technical aspects of arthroscopic surgery for AAIS</title>
<sec id="s4a"><label>4.1</label><title>Indications and contraindications</title>
<p>Arthroscopic intervention for AAIS is principally indicated for patients who demonstrate persistent symptoms after at least three months of conservative management (including physical therapy, pharmacologic intervention, and intra-articular injections), accompanied by functional impairment, radiographically confirmed osteophytes (Scranton-McDermott type II-IV), or soft tissue impingement (van Dijk classification), or when both diagnosis and treatment are required (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B15">15</xref>, <xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B18">18</xref>). It is also relatively indicated for high-performance athletes seeking a faster return to sport.</p>
<p>Contraindications require careful assessment, including advanced ankle osteoarthritis (Takakura stage III or higher) with marked joint space narrowing, active local or systemic infection, severe peripheral vascular disease, and poor patient compliance (<xref ref-type="bibr" rid="B19">19</xref>, <xref ref-type="bibr" rid="B20">20</xref>). Notably, diabetes and smoking are relative contraindications, but patients should be informed of the increased risk of poor wound healing and infection (<xref ref-type="bibr" rid="B20">20</xref>).</p>
</sec>
<sec id="s4b"><label>4.2</label><title>Surgical technique</title>
<p>Arthroscopic treatment of anterior ankle impingement syndrome typically follows a standardized dual-portal approach through anteromedial and anterolateral access points (<xref ref-type="bibr" rid="B16">16</xref>). The patient is positioned supine with a proximal thigh tourniquet, and the ankle extended beyond the operating table to optimize access to the joint. Accurate portal placement is essential&#x2014;the anterolateral portal is established 1&#x2005;cm proximal to the joint line, lateral to the peroneus tertius tendon, while the anteromedial portal is created 1&#x2005;cm proximal and medial to the tibialis anterior tendon, ensuring protection of the superficial peroneal and saphenous nerves (<xref ref-type="bibr" rid="B8">8</xref>&#x2013;<xref ref-type="bibr" rid="B12">12</xref>).</p>
<p>The procedures begins with a systematic exploration of the joint, following the sequence: medial gutter, central compartment, and lateral gutter (<xref ref-type="bibr" rid="B7">7</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B15">15</xref>, <xref ref-type="bibr" rid="B19">19</xref>). Surgeons use 3.5&#x2013;4.0&#x2005;mm arthroscopes with compatible shavers, maintaining joint distension with controlled irrigation (30&#x2013;40&#x2005;mmHg) and intermittent tourniquet inflation in 60-min cycles (<xref ref-type="bibr" rid="B7">7</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B12">12</xref>). Osteophytes are removed using curved osteotomes or burrs, following a peripheral-to-central approach to preserve intact articular cartilage (<xref ref-type="bibr" rid="B7">7</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>). Synovial debridement is performed using radiofrequency ablation or mechanical resection, focusing on hypertrophic areas while preserving healthy synovium. Ligamentous structures are managed conservatively, trimming only fibrotic portions to maintain joint stability (<xref ref-type="bibr" rid="B7">7</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B15">15</xref>). Careful hemostasis and periodic tourniquet release throughout the procedure minimize soft tissue trauma and enhance visualization.</p>
</sec>
<sec id="s4c"><label>4.3</label><title>Intraoperative challenges and solutions</title>
<p>Several technical challenges may occur during arthroscopic AAIS management, each necessitating tailored strategies. Suboptimal visualization, especially in cases of extensive synovitis or fibrosis, can be managed with a stepwise approach: increasing irrigation pressure (up to 50&#x2005;mmHg), switching to a 2.7&#x2005;mm arthroscope if necessary, using radiofrequency ablation to achieve hemostasis, and, if needed, creating additional portals to ensure procedural safety (<xref ref-type="bibr" rid="B21">21</xref>, <xref ref-type="bibr" rid="B22">22</xref>).</p>
<p>Neurovascular protection is critical, as the anterolateral portal poses a 3.6&#x0025; risk of superficial peroneal nerve injury, and the anteromedial portal requires safeguarding the saphenous neurovascular bundle (<xref ref-type="bibr" rid="B23">23</xref>&#x2013;<xref ref-type="bibr" rid="B25">25</xref>). A standardized safety protocol involves preoperative mapping and skin marking of superficial neurovascular structures, use of blunt dissection for portal creation, and continuous visualization of instrument tips during all intra-articular steps (<xref ref-type="bibr" rid="B23">23</xref>&#x2013;<xref ref-type="bibr" rid="B25">25</xref>).</p>
<p>Preventing postoperative adhesion involves several evidence-based strategies: complete hemostasis before wound closure, early passive range-of-motion exercises (within 24&#x2005;h), use of hyaluronate-based anti-adhesion barriers in high-risk cases, and application of continuous passive motion devices for 2&#x2013;3 weeks in patients with a history of arthrofibrosis (<xref ref-type="bibr" rid="B26">26</xref>, <xref ref-type="bibr" rid="B27">27</xref>). These combined measures address common intraoperative challenges and help ensure both procedural success and favorable long-term outcomes (<xref ref-type="bibr" rid="B26">26</xref>, <xref ref-type="bibr" rid="B27">27</xref>).</p>
</sec>
</sec>
<sec id="s5"><label>5</label><title>Clinical outcomes and evidence</title>
<sec id="s5a"><label>5.1</label><title>Literature review</title>
<p>Recent prospective and retrospective studies have consistently confirmed the effectiveness of arthroscopic surgery in treating AAIS (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B11">11</xref>, <xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B28">28</xref>&#x2013;<xref ref-type="bibr" rid="B48">48</xref>) (<xref ref-type="table" rid="T1">Table&#x00A0;1</xref>). Notably, Nihal et al. (<xref ref-type="bibr" rid="B28">28</xref>) reported that 75&#x0025; (9/12) of dancers resumed full activity within an average of seven weeks postoperatively, demonstrating the procedure&#x0027;s value in high-demand populations. Cuellar-Avaroma et al. (<xref ref-type="bibr" rid="B29">29</xref>) reported significant improvements in a 52-patient cohort, with visual analog scale (VAS) pain scores decreasing from 5.75 to 0.98 and American orthopedic foot &#x0026; ankle society (AOFAS) scores increasing from 73.65 to 92.98. Additionally, 44.23&#x0025; of patients returned to pre-injury sports within 4&#x2013;7 months. Wang et al. (<xref ref-type="bibr" rid="B30">30</xref>) compared dual- and triple-portal arthroscopy, finding no significant differences in AOFAS scores (76.18 vs. 79.18) or dorsiflexion (21.36&#x00B0; vs. 20.45&#x00B0;), although the triple-portal approach was more beneficial in severe cases.</p>
<table-wrap id="T1" position="float"><label>Table&#x00A0;1</label>
<caption><p>Summarizing the key details of studies on arthroscopic surgery for AAIS.</p></caption>
<table>
<thead>
<tr>
<th valign="top" align="left">Study</th>
<th valign="top" align="center">Patients</th>
<th valign="top" align="center">Publication type</th>
<th valign="top" align="center">Treatment</th>
<th valign="top" align="center">Main findings</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Tol et al. (<xref ref-type="bibr" rid="B10">10</xref>)</td>
<td valign="top" align="left">57 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Excellent/good results in all patients without OA.</p></list-item>
<list-item><label>-</label><p>77&#x0025; of grade-I OA patients had excellent/good results despite osteophyte recurrence.</p></list-item>
<list-item><label>-</label><p>53&#x0025; of grade-II OA patients had excellent/good results.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Baums et al. (<xref ref-type="bibr" rid="B11">11</xref>)</td>
<td valign="top" align="left">26 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Karlsson score improved from 66 to 92 (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.05).</p></list-item>
<list-item><label>-</label><p>Tegner score improved from 3 to 8.</p></list-item>
<list-item><label>-</label><p>96&#x0025; patient satisfaction.</p></list-item>
<list-item><label>-</label><p>No difference between soft-tissue vs. bony impingement outcomes.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">van Dijk et al. (<xref ref-type="bibr" rid="B16">16</xref>)</td>
<td valign="top" align="left">62 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>90&#x0025; good/excellent results without OA vs. 50&#x0025; with OA.</p></list-item>
<list-item><label>-</label><p>Medial spurs had better outcomes.</p></list-item>
<list-item><label>-</label><p>Shorter pain duration (&#x003C;2 yrs) predicted better results.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Nihal et al. (<xref ref-type="bibr" rid="B28">28</xref>)</td>
<td valign="top" align="left">11 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>82&#x0025; returned to dance (7 weeks).</p></list-item>
<list-item><label>-</label><p>2 reoperations (recurrent spur/scar tissue).</p></list-item>
<list-item><label>-</label><p>Minimal morbidity.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Cuellar-Avaroma et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td valign="top" align="left">52 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Pain scale improved from 5.75 &#x2192; 0.98.</p></list-item>
<list-item><label>-</label><p>AOFAS improved from 73.65 &#x2192; 92.98.</p></list-item>
<list-item><label>-</label><p>44&#x0025; returned to sports (4&#x2013;7 months).</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Wang et al. (<xref ref-type="bibr" rid="B30">30</xref>)</td>
<td valign="top" align="left">52 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>No significant difference in AOFAS/VAS/dorsiflexion between groups.</p></list-item>
<list-item><label>-</label><p>3-portal suggested for advanced impingement.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Murawski et al. (<xref ref-type="bibr" rid="B31">31</xref>)</td>
<td valign="top" align="left">41 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>93&#x0025; patient satisfaction.</p></list-item>
<list-item><label>-</label><p>AOFAS scores improved from 62.83 to 91.17 (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.001).</p></list-item>
<list-item><label>-</label><p>97&#x0025; returned to prior sports level.</p></list-item>
<list-item><label>-</label><p>7&#x0025; complication rate.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Jerosch et al. (<xref ref-type="bibr" rid="B32">32</xref>)</td>
<td valign="top" align="left">35 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Pain improved significantly (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.05).</p></list-item>
<list-item><label>-</label><p>Only 26&#x0025; returned to prior sports level.</p></list-item>
<list-item><label>-</label><p>17&#x0025; had temporary neurological complications.</p></list-item>
<list-item><label>-</label><p>Hypermobile ankles had worse outcomes.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Branca et al. (<xref ref-type="bibr" rid="B33">33</xref>)</td>
<td valign="top" align="left">58 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Postoperative McGuire scores: 37 good, 13 fair, 8 poor.</p></list-item>
<list-item><label>-</label><p>Recurrence in severe cases (McDermott stage III/IV). No major complications.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Rouvillain et al. (<xref ref-type="bibr" rid="B34">34</xref>)</td>
<td valign="top" align="left">24 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>92&#x0025; excellent results (Kitaoka score).</p></list-item>
<list-item><label>-</label><p>No major complications (2 transient hypoesthesias, resolved by 6 months).</p></list-item>
<list-item><label>-</label><p>No distraction needed (simple dorsiflexion sufficient).</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Akseki et al. (<xref ref-type="bibr" rid="B35">35</xref>)</td>
<td valign="top" align="left">21 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>81&#x0025; (17/21) good/excellent results.</p></list-item>
<list-item><label>-</label><p>90&#x0025; patient satisfaction.</p></list-item>
<list-item><label>-</label><p>2 poor results due to neuromas (resolved with steroids).</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Arnold (<xref ref-type="bibr" rid="B36">36</xref>)</td>
<td valign="top" align="left">32 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>81&#x0025; (26/32) good/excellent results (West Point Ankle Score &#x2265;80).</p></list-item>
<list-item><label>-</label><p>Worse outcomes with severe chondral lesions.</p></list-item>
<list-item><label>-</label><p>Effective for synovium/fibrous bands (type I) and tibial spurs (types II&#x2013;III).</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Yang et al. (<xref ref-type="bibr" rid="B37">37</xref>)</td>
<td valign="top" align="left">22 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>AAI group had worse pre-op scores but no difference post-op.</p></list-item>
<list-item><label>-</label><p>Dorsiflexion improved (13&#x00B0; &#x2192; 26&#x00B0;).</p></list-item>
<list-item><label>-</label><p>No osteophyte recurrence.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Devgan et al. (<xref ref-type="bibr" rid="B38">38</xref>)</td>
<td valign="top" align="left">14 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Both groups improved (AOFAS: 50.5 &#x2192; 85.71).</p></list-item>
<list-item><label>-</label><p>Soft tissue group had slightly better range of motion and faster return to sports.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Ferkel et al. (<xref ref-type="bibr" rid="B39">39</xref>)</td>
<td valign="top" align="left">31 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>84&#x0025; (26/31) excellent/good results.</p></list-item>
<list-item><label>-</label><p>MRI useful for diagnosing synovial thickening.</p></list-item>
<list-item><label>-</label><p>Average return to sports: 6 weeks.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Hassan (<xref ref-type="bibr" rid="B40">40</xref>)</td>
<td valign="top" align="left">23 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>AOFAS improved from 34 to 89.</p></list-item>
<list-item><label>-</label><p>91&#x0025; (21/23) excellent/good results.</p></list-item>
<list-item><label>-</label><p>96&#x0025; would repeat surgery.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Koczy et al. (<xref ref-type="bibr" rid="B41">41</xref>)</td>
<td valign="top" align="left">22 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>AOFAS improved from 75.4 to 92 at 12 months.</p></list-item>
<list-item><label>-</label><p>1 case of temporary nerve palsy.</p></list-item>
<list-item><label>-</label><p>Effective for post-sprain/fracture impingement.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Walsh et al. (<xref ref-type="bibr" rid="B42">42</xref>)</td>
<td valign="top" align="left">46 patients with AAIS</td>
<td valign="top" align="left">Prospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Foot Functional Index improved (20.5 &#x2192; 2.7).</p></list-item>
<list-item><label>-</label><p>Minimal dorsiflexion improvement (24.7&#x00B0; &#x2192; 27&#x00B0;).</p></list-item>
<list-item><label>-</label><p>84&#x0025; had osteophyte recurrence but no functional decline.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Liu et al. (<xref ref-type="bibr" rid="B43">43</xref>)</td>
<td valign="top" align="left">55 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>87&#x0025; good/excellent results.</p></list-item>
<list-item><label>-</label><p>98&#x0025; patient satisfaction.</p></list-item>
<list-item><label>-</label><p>84&#x0025; returned to sports.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Brennan et al. (<xref ref-type="bibr" rid="B44">44</xref>)</td>
<td valign="top" align="left">41 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Visual-Analogue-Scale Foot and Ankle scores improved from 44.5 to 78.3 (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.0001).</p></list-item>
<list-item><label>-</label><p>83&#x0025; good/excellent results (Meislin criteria).</p></list-item>
<list-item><label>-</label><p>MRI underreported synovitis/impingement.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Cavallo et al. (<xref ref-type="bibr" rid="B45">45</xref>)</td>
<td valign="top" align="left">600 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>80&#x0025; good/excellent results for impingement.</p></list-item>
<list-item><label>-</label><p>AOFAS scores improved postoperatively.</p></list-item>
<list-item><label>-</label><p>Effective for ligament injuries, fractures, and osteochondral lesions.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Mardani-Kivi et al. (<xref ref-type="bibr" rid="B46">46</xref>)</td>
<td valign="top" align="left">23 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>AOFAS scores improved from 59.21 pre-op to 88.13 at 6 months.</p></list-item>
<list-item><label>-</label><p>No significant difference in outcomes between patients with/without chondral lesions.</p></list-item>
<list-item><label>-</label><p>Effective even with chondral damage.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">Ogilvie-Harris et al. (<xref ref-type="bibr" rid="B47">47</xref>)</td>
<td valign="top" align="left">17 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>Significant improvement in pain, swelling, stiffness, and dorsiflexion.</p></list-item>
<list-item><label>-</label><p>1 poor result (superficial infection).</p></list-item>
<list-item><label>-</label><p>2 cases of transient foot numbness.</p></list-item>
</list></td>
</tr>
<tr>
<td valign="top" align="left">&#x00DC;rg&#x00FC;den et al. (<xref ref-type="bibr" rid="B48">48</xref>)</td>
<td valign="top" align="left">41 patients with AAIS</td>
<td valign="top" align="left">Retrospective study</td>
<td valign="top" align="left">Arthroscopic surgery</td>
<td valign="top" align="left">
<list list-type="simple">
<list-item><label>-</label><p>90&#x0025; excellent/good results (Meislin criteria).</p></list-item>
<list-item><label>-</label><p>Mean AOFAS: 89.6.</p></list-item>
<list-item><label>-</label><p>Poor outcomes linked to: Chondral damage (not subchondral); Post-op reinjury.</p></list-item>
</list></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TF1"><p>AAIS, Anterior ankle impingement syndrome; OA, osteoarthritis; AOFAS, American Orthopaedic Foot &#x0026; Ankle Society Ankle-Hindfoot Scale; VAS, Visual Analog Scale; MRI, Magnetic Resonance Imaging.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>Murawski et al. (<xref ref-type="bibr" rid="B31">31</xref>) observed a significant AOFAS score improvement from 62.83 to 91.17 (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.001) in 41 patients with anteromedial impingement, with 93&#x0025; patient satisfaction and 97&#x0025; return to sports. In contrast, Jerosch et al. (<xref ref-type="bibr" rid="B32">32</xref>) found that only 25.7&#x0025; of athletes returned to their pre-injury activity levels after partial synovectomy, suggesting worse outcomes in patients with concomitant joint laxity.</p>
<p>Success rates commonly exceed 80&#x0025;. Tol et al. (<xref ref-type="bibr" rid="B16">16</xref>) reported 100&#x0025; excellent outcomes in patients without osteoarthritis (OA), which declined to 77&#x0025; in those with mild OA (Scranton-McDermott grade I), and noted osteophyte recurrence in two-thirds of cases. Branca et al. (<xref ref-type="bibr" rid="B33">33</xref>) found a 63.8&#x0025; excellent rate based on McGuire score, but also reported higher recurrence in advanced OA cases (Scranton-McDermott III&#x2013;IV).</p>
<p>Complications are uncommon (2&#x0025;&#x2013;7&#x0025;), mainly involving transient nerve injuries (e.g., superficial peroneal nerve palsy) (<xref ref-type="bibr" rid="B30">30</xref>, <xref ref-type="bibr" rid="B34">34</xref>). Akseki et al. (<xref ref-type="bibr" rid="B35">35</xref>) described two cases of postoperative neuroma-related pain, both of which were resolved with steroid injections. Arnold (<xref ref-type="bibr" rid="B36">36</xref>) reported excellent west point ankle scores (mean score: 86) in 81.3&#x0025; of cases, although results were poorer in patients with severe cartilage damage.</p>
</sec>
<sec id="s5b"><label>5.2</label><title>Outcome measures</title>
<p>The assessment of arthroscopic outcomes for anterior ankle impingement relies on validated subjective and objective measures. For subjective evaluation, the VAS and AOFAS scores are the primary tools, showing consistent sensitivity to postoperative improvement. Yang et al. (<xref ref-type="bibr" rid="B37">37</xref>) reported significant AOFAS score improvement from 62.9 to 89.2 (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.01) in patients with both anterior ankle impingement and chronic ankle instability, with results comparable to those with isolated instability. Similarly, Devgan et al. (<xref ref-type="bibr" rid="B38">38</xref>) observed substantial improvements in both osseous and soft tissue impingement, with AOFAS scores rising from 50.5 to 85.71 (<italic>P</italic>&#x2009;&#x003D;&#x2009;0.0001) and high patient satisfaction (mean Likert score 4.21/5). These findings are supported by multiple studies showing excellent functional recovery. For example, Ferkel et al. (<xref ref-type="bibr" rid="B39">39</xref>) reported 83.9&#x0025; excellent/good outcomes at 2-year follow-up (15 excellent, 11 good out of 31 patients), with an average return to sports in six weeks. Hassan (<xref ref-type="bibr" rid="B40">40</xref>) observed a dramatic AOFAS improvement from 34 to 89 in 23 patients, with 95.7&#x0025; of them willing to undergo the procedure again. Koczy et al. (<xref ref-type="bibr" rid="B41">41</xref>) further confirmed these favorable results, with AOFAS scores improving from 75.4 to 92, and only one case of transient neurapraxia among 22 patients.</p>
<p>Objective measures complement subjective assessments and further demonstrate surgical efficacy. Dorsiflexion range of motion (ROM) is a key functional metric. Walsh et al. (<xref ref-type="bibr" rid="B42">42</xref>) showed a significant improvement from 24.7&#x00B0; to 27.0&#x00B0; (<italic>P</italic>&#x2009;&#x003D;&#x2009;0.049) despite an 84&#x0025; osteophyte recurrence rate, highlighting the disconnect between radiographic findings and clinical symptoms. Liu et al. (<xref ref-type="bibr" rid="B43">43</xref>) reported restored normal ankle ROM in 87&#x0025; of patients. Imaging studies revealed modality-specific limitations&#x2014;MRI had low sensitivity with a 40&#x0025; false-negative rate for soft tissue impingement (<xref ref-type="bibr" rid="B44">44</xref>), whereas standard radiographs were more reliable for detecting osseous lesions (<xref ref-type="bibr" rid="B37">37</xref>). Large-scale analyses support these findings. Cavallo et al.&#x0027;s (<xref ref-type="bibr" rid="B45">45</xref>) conducted a systematic review of over 600 cases, reporting 80&#x0025; excellent outcomes and significant AOFAS improvement. Mardani-Kivi et al. (<xref ref-type="bibr" rid="B46">46</xref>) showed comparable 6-month AOFAS scores (88.13) regardless of cartilage status, reinforcing the value of arthroscopy even in complex cases with chondral pathology.</p>
</sec>
<sec id="s5c"><label>5.3</label><title>Long-term follow-up</title>
<p>Long-term studies show that the durability of arthroscopic outcomes is closely related to the degree of pre-existing joint degeneration. Tol et al. (<xref ref-type="bibr" rid="B10">10</xref>) demonstrated this assassination in a 6.5-year follow-up, reported sustained excellent outcomes in patients without OA, compared to only 53&#x0025; excellent outcomes in those with grade II OA-notably, without progressive joint space narrowing. Walsh et al. (<xref ref-type="bibr" rid="B42">42</xref>) further supported long-term benefits, reporting foot functional index scores improving from 20.5 to 2.7 (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.001) at five years, despite an 84&#x0025; recurrence of osteophytes, again highlighting the disconnect between imaging and symptoms. The safety profile of arthroscopy remains favorable over time. Ogilvie-Harris et al. (<xref ref-type="bibr" rid="B47">47</xref>) reported durable pain relief and ROM improvement at 39 months in osseous impingement, with only one superficial infection in 17 patients. Rouvillain et al. (<xref ref-type="bibr" rid="B34">34</xref>) achieved 91.7&#x0025; excellent outcomes using traction-free techniques in a 24-patient series, with no long-term complications. However, degenerative progression remain a concern. Baums et al. (<xref ref-type="bibr" rid="B11">11</xref>) reported similar 31-month outcomes (Karlsson score&#x2009;&#x003D;&#x2009;92) regardless of cartilage status. In contrast, &#x00DC;rg&#x00FC;den et al. (<xref ref-type="bibr" rid="B48">48</xref>) found a significantly worse prognosis (<italic>P</italic>&#x2009;&#x003C;&#x2009;0.005) in patients with deep cartilage lesions at 83.7-month follow-up, especially when combined with recurrent sprains.</p>
<p>These findings collectively support arthroscopy as a durable and effective treatment for anterior ankle impingement, particularly in patients without advanced OA. For those with greater degeneration, adjunctive therapies may help optimize long-term outcomes (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B42">42</xref>).</p>
</sec>
</sec>
<sec id="s6"><label>6</label><title>Controversies and future perspectives in arthroscopic management of AAIS</title>
<sec id="s6a"><label>6.1</label><title>Current debates in surgical management</title>
<p>The choice between arthroscopic and open surgical approaches for ankle arthritis remains controversial. While Lorente et al. (<xref ref-type="bibr" rid="B49">49</xref>) reported similar fusion rates (OR&#x2009;&#x003D;&#x2009;&#x2009;0.54, <italic>P</italic>&#x2009;&#x003D;&#x2009;0.072), Bai et al. (<xref ref-type="bibr" rid="B50">50</xref>) found better outcomes with arthroscopy (OR&#x2009;&#x003D;&#x2009;&#x2009;3.32). Arthroscopy offers clear advantages, including shorter hospital stay (MD&#x2009;&#x003D;&#x2009;2.29 days, <italic>P</italic>&#x2009;&#x003D;&#x2009;0.017), fewer complications (OR&#x2009;&#x003D;&#x2009;0.47, <italic>P</italic>&#x2009;&#x003D;&#x2009;0.016), and faster recovery times (MD&#x2009;&#x003D;&#x2009;&#x2212;2.31 weeks). However, open surgery may be preferred for severe cases with &#x003E;5&#x2005;mm osteophytes, as it achieves higher complete resection rates (92&#x0025; vs. 78&#x0025;). Emerging precision techniques, such as CT-guided portal placement, enhance visualization (35&#x2009;&#x00B1;&#x2009;8&#x00B0;, <italic>P</italic>&#x2009;&#x003C;&#x2009;0.01) but require further clinical validation. Future research should focus on standardized clinical trials to optimize patient selection and assess long-term outcomes.</p>
</sec>
<sec id="s6b"><label>6.2</label><title>Critical limitations in current AAIS research</title>
<p>Although arthroscopic techniques show promise in AAIS management, four major methodological limitations reduce the reliability of current evidence. First, most studies are underpowered, retrospective or single-center series with small sample sizes (typically &#x003C;100 cases), which introduces selection bias and prevents meaningful subgroup analysis by impingement type (osseous vs. soft tissue) (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B42">42</xref>). Second, there is substantial heterogeneity in outcome reporting. Cavallo et al. (<xref ref-type="bibr" rid="B45">45</xref>) identified 17 different assessment tools across 42 studies, ranging from validated scales like AOFAS to subjective surgeon-based ratings (e.g., &#x201C;excellent/good&#x201D; ratings). Third, long-term efficacy data are limited-only 18.6&#x0025; of studies include &#x2265;5-year follow-up (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B42">42</xref>, <xref ref-type="bibr" rid="B48">48</xref>), leaving key questions about postoperative osteoarthritis progression unanswered. Fourth, temporal bias is a major concern in the current literature. Only 12.5&#x0025; (3/24) of the included studies were published after 2016, despite significant advancements in arthroscopic and open surgical techniques during that time. This gap may lead to under-representation of current success rates or complication profiles, especially for advanced techniques like robotic-assisted debridement. As a result, caution is warranted when applying these findings to current practice, emphasizing the need for updated systematic reviews incorporating post-2016 evidence. To address these limitations, coordinated multi-center RCTs are needed, incorporating: (1) standardized outcome measures, (2) at least 5 years of follow-up using structural MRI and functional endpoints, and (3) economic evaluations to assess value-based adoption thresholds.</p>
</sec>
</sec>
<sec id="s7" sec-type="summary"><label>7</label><title>Summary</title>
<p>Arthroscopic surgery is the current standard of care for AAIS, supported by level I evidence showing better patient-reported outcomes, faster functional recovery, and fewer complications compared to open techniques. Its main advantages include precise removal of osseous and soft tissue lesions, minimal disruption to joint biomechanics, and lower perioperative morbidity. However, achieving optimal outcomes requires a multidisciplinary approach, including dynamic preoperative imaging, personalized surgical planning, and structured rehabilitation.</p>
<p>Despite these advances, important gaps remain, particularly regarding long-term degenerative changes and the cost-effectiveness of new technologies. Furthermore, comparative effectiveness studies should address socioeconomic disparities in access to these emerging treatment options. The orthopedic community must prioritize rigorous long-term studies to improve surgical decision-making and ensure value-based care for AAIS patients across diverse populations.</p>
</sec>
</body>
<back>
<sec id="s9" sec-type="author-contributions"><title>Author contributions</title>
<p>L-ZZ: Conceptualization, Data curation, Methodology, Resources, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. YF: Conceptualization, Data curation, Methodology, Resources, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. D-YB: Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec id="s11" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s12" sec-type="ai-statement"><title>Generative AI statement</title>
<p>The author(s) declare that no Generative AI was used in the creation of this manuscript.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p>
</sec>
<sec id="s13" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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<fn-group>
<fn id="n1" fn-type="custom" custom-type="edited-by"><p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2981292/overview">S. W. Kong</ext-link>, Asia Medical Specialists, Hong Kong, SAR China</p></fn>
<fn id="n2" fn-type="custom" custom-type="reviewed-by"><p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2250787/overview">Cristian Indino</ext-link>, Humanitas San Pio X Hospital, Italy</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3063046/overview">Claudius Illg</ext-link>, BG Clinic Tuebingen, Germany</p></fn>
</fn-group>
<fn-group>
<fn fn-type="abbr" id="abbrev1"><label>Abbreviations:</label><p>AAIS, anterior ankle impingement syndrome; 3D, three-dimensional; VAS, Visual Analog Scale; AOFAS, American Orthopedic Foot &#x0026; Ankle Society; OA, osteoarthritis; MRI, Magnetic Resonance Imaging; CT, Computed Tomography; ROM, range of motion.</p></fn>
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