<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<article article-type="editorial" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xml:lang="EN">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Surg.</journal-id>
<journal-title>Frontiers in Surgery</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Surg.</abbrev-journal-title>
<issn pub-type="epub">2296-875X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fsurg.2023.1234200</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Surgery</subject>
<subj-group>
<subject>Editorial</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Editorial: Surgical outcomes in acute care surgery: should we introduce the concept of time-critical condition?</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><name><surname>Fransvea</surname><given-names>Pietro</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref><uri xlink:href="https://loop.frontiersin.org/people/1526308/overview"/></contrib>
<contrib contrib-type="author"><name><surname>La Greca</surname><given-names>Antonio</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/1542558/overview" /></contrib>
<contrib contrib-type="author"><name><surname>Giovinazzo</surname><given-names>Francesco</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/544991/overview" /></contrib>
<contrib contrib-type="author"><name><surname>Costa</surname><given-names>Gianluca</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib>
<contrib contrib-type="author"><name><surname>Sganga</surname><given-names>Gabriele</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/1803507/overview" /></contrib>
</contrib-group>
<aff id="aff1"><label><sup>1</sup></label><addr-line>Emergency Surgery and Trauma</addr-line>, <institution>Fondazione Policlinico Universitario A. Gemelli, IRCCS Roma - Universit&#x00E0; Cattolica del Sacro Cuore</institution>, <addr-line>Rome</addr-line>, <country>Italy</country></aff>
<aff id="aff2"><label><sup>2</sup></label><addr-line>Unit of General and Liver Transplant Surgery</addr-line>, <institution>Fondazione Policlinico Universitario A. Gemelli, IRCCS, Universit&#x00E0; Cattolica del Sacro Cuore</institution>, <addr-line>Rome</addr-line>, <country>Italy</country></aff>
<aff id="aff3"><label><sup>3</sup></label><addr-line>Colorectal Surgery Unit, Surgery Center</addr-line>, <institution>Fondazione Policlinico Universitario Campus Bio-Medico, University Campus Bio-Medico of Rome</institution>, <addr-line>Rome</addr-line>, <country>Italy</country></aff>
<author-notes>
<fn fn-type="edited-by"><p><bold>Edited and Reviewed by:</bold> Aali Jan Sheen, Manchester Royal Infirmary, United Kingdom</p></fn>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Pietro Fransvea <email>pietro.fransvea@policlinicogemelli.it</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>26</day><month>07</month><year>2023</year></pub-date>
<pub-date pub-type="collection"><year>2023</year></pub-date>
<volume>10</volume><elocation-id>1234200</elocation-id>
<history>
<date date-type="received"><day>03</day><month>06</month><year>2023</year></date>
<date date-type="accepted"><day>13</day><month>06</month><year>2023</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2023 Fransvea, La Greca, Giovinazzo, Costa and Sganga.</copyright-statement>
<copyright-year>2023</copyright-year><copyright-holder>Fransvea, La Greca, Giovinazzo, Costa and Sganga</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<kwd-group>
<kwd>outcomes</kwd>
<kwd>surgery</kwd>
<kwd>acute care</kwd>
<kwd>precision surgery</kwd>
<kwd>morbidity</kwd>
</kwd-group><counts>
<fig-count count="0"/>
<table-count count="0"/><equation-count count="0"/><ref-count count="32"/><page-count count="0"/><word-count count="0"/></counts><custom-meta-wrap><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>Surgical Oncology</meta-value></custom-meta></custom-meta-wrap>
</article-meta>
</front>
<body>
<p><bold>Editorial on the Research Topic</bold> <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/research-topics/38156/acute-care-surgery-emergency-surgery-surgical-outcomes">Acute care surgery, emergency surgery, surgical outcomes</ext-link></p>
<sec id="s1" sec-type="intro"><title>Introduction</title>
<p>Patients undergoing Emergency Gastrointestinal Surgery (EGS) are so heterogeneous in terms of procedures they receive, comorbidities and physiologic derangement at the time of diagnosis and treatment that perioperative risk stratification, surgical planning and risk mitigation may be exceedingly cumbersome. Nonetheless, EGS, while representing about 15&#x0025; of the whole surgical burden worldwide, still accounts for more than 50&#x0025; of global surgical morbidity and mortality (<xref ref-type="bibr" rid="B2">2</xref>). Thus, a structured decision-making process, with accurate risk stratification and patients&#x0027; priority addressing (<xref ref-type="bibr" rid="B3">3</xref>&#x2013;<xref ref-type="bibr" rid="B5">5</xref>), seems even more crucial in the emergency than in the elective setting. On one hand, we need to better assess EGS patients&#x0027; needs and improve surgical outcomes in the emergency setting. How? First, perioperative risk stratification is crucial to improve shared decision-making among the care team and the patient, perioperative planning, and risk mitigation (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B8">8</xref>). As suggested by Yun Il, several factors are thought to be related to the postoperative outcome, but frailty has recently gained increased attention and its preoperative screening has been advocated as a critical tool in predicting length of stay, operative risk, and surgical outcomes in the elderly (<xref ref-type="bibr" rid="B1">1</xref>). Second, as reported by Eydivandi N, a thorough attention in intraoperative care items, such as levels of carbon dioxide insufflation, analgesia, i.v. fluid load, has a pivotal role in preventing post-operative surgical complications. In this respect, the so called &#x201C;Enhanced recovery after emergency surgery&#x201D; concept may represent the new frontier of perioperative care for EGS patients (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>). Finally, as reported by <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fsurg.2022.969038">Ali et al.</ext-link>, the Clavien&#x2013;Dindo classification still plays a crucial role in assessing postoperative complications and predicting the impact of surgery on quality of life (<xref ref-type="bibr" rid="B8">8</xref>). On the other hand, the new emerging concept of EGS as a time dependent condition can help achieving early diagnosis and treatment, thus improving outcomes and reducing health care costs (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>). During the COVID19 pandemic, we have witnessed a dramatic decrease in surgical emergencies but also an increase in the severity of acute diseases, as patients, frightened by the risk of contagion, went late to the ED. Definitive treatment was often postponed in favour of a non-operative treatment (NOM), both due to concomitant Sars-Cov-2 infection in these patients as well as to shortage of resources (such as ICU beds and surgical rooms) engaged with COVID-19 patients (<xref ref-type="bibr" rid="B11">11</xref>). If we look at a single disease such as acute appendicitis, several studies have shown that a conservative approach may further increase the risk of recurrence: more than one third of the patients treated by antibiotics only have been re-admitted for a recurrent episode of appendicitis (<xref ref-type="bibr" rid="B12">12</xref>&#x2013;<xref ref-type="bibr" rid="B16">16</xref>). Moreover, a systematic review and metanalysis by Podda et al. showed that appendectomy remains the most effective treatment for patients with uncomplicated acute appendicitis and that antibiotics-first strategy for uncomplicated acute appendicitis in adults is associated with increased rates of peritonitis at surgery (<xref ref-type="bibr" rid="B16">16</xref>). Coming to the general landscape of EGS, it is well known that a prolonged waiting time from the onset of symptoms to surgical treatment is directly related to an increased risk of major bowel resection and postoperative complications (<xref ref-type="bibr" rid="B17">17</xref>&#x2013;<xref ref-type="bibr" rid="B19">19</xref>). Peritonitis due to gastric perforation is associated with an increasing risk of mortality of 2&#x0025; for each hour of delay in surgical treatment after the diagnosis (<xref ref-type="bibr" rid="B20">20</xref>&#x2013;<xref ref-type="bibr" rid="B23">23</xref>). Patients with acute cholecystitis should undergo surgery within a time lapse of less than 10 days, such as stated in modern guidelines (<xref ref-type="bibr" rid="B24">24</xref>&#x2013;<xref ref-type="bibr" rid="B29">29</xref>). Femur fractures should receive a definitive surgical treatment within 48&#x2005;h from diagnosis, as this time cut-off is directly linked to better outcomes (<xref ref-type="bibr" rid="B30">30</xref>). Delay in the treatment of acute diseases is not only of ethical interest in terms of harm for the patient, but also has a critical impact in terms of social costs arising from the disability and reduced productivity of the injured. This concept is worldwide accepted for the so-called time-dependent acute diseases such as stroke, acute myocardial infarction and polytrauma: maybe we should think about acute abdominal pain as a time-dependent disease also. Based on the evidence of the literature and common surgeons&#x0027; experience, we hypothesized a &#x201C;Traffic Light System&#x201D; (TLS) for patient waiting in the ED with surgical diseases needing an operative treatment based on the waiting time since arrival. When a diagnosis is done, the patient enters in the &#x201C;green light&#x201D; status and is ready for surgery. If surgery cannot be performed timely, patients enter in a &#x201C;yellow light&#x201D; status, acquiring priority over other diseases. &#x201C;Red light&#x201D; means that the patient cannot wait anymore and needs a prompt treatment. With this simple stratification system, waiting times for surgery in the emergency department may decrease together with the need for major resections, morbidity and mortality rates. Last but not least, new technologies such as robotic platforms and machine learning models, though affected by high costs, can help achieve better outcomes in EGS. In this context, a paradigm shift may be represented by the application of the so-called &#x201C;precision surgery&#x201D; concept to acute care surgery: a global effort in education and practice to ensure an elevated standard of care to all acute care surgery patients in terms of knowledge, technical skills, technology and commitment leading to a reduction in healthcare costs, including costs for chronic post-surgical disability (<xref ref-type="bibr" rid="B31">31</xref>, <xref ref-type="bibr" rid="B32">32</xref>).</p>
</sec>
</body>
<back>
<sec id="s2" sec-type="author-contributions"><title>Author contributions</title>
<p>All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.</p>
</sec>
<ack><title>Acknowledgments</title>
<p>We deeply thank all the authors and reviewers who have participated in this Research Topic.</p>
</ack>
<sec id="s3" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s4" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<ref-list><title>References</title>
<ref id="B1"><label>1.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Costa</surname><given-names>G</given-names></name><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>Puccioni</surname><given-names>C</given-names></name><name><surname>Giovinazzo</surname><given-names>F</given-names></name><name><surname>Carannante</surname><given-names>F</given-names></name><name><surname>Bianco</surname><given-names>G</given-names></name><etal/></person-group> <article-title>Gastro-intestinal 139 emergency surgery: Evaluation of morbidity and mortality. Protocol of a prospective, 140 multicentre study in Italy for evaluating the burden of abdominal emergency surgery in 141 different age groups. (The GESEMM study)</article-title>. <source>Front Surg</source>. (<year>2022</year>) <volume>9</volume>:<fpage>927044</fpage>. <pub-id pub-id-type="doi">10.3389/fsurg.2022.927044</pub-id>. eCollection 2022<pub-id pub-id-type="pmid">36189400</pub-id></citation></ref>
<ref id="B2"><label>2.</label><citation citation-type="other"><comment>Available at:</comment> <ext-link ext-link-type="uri" xlink:href="https://www.nela.org.uk/">https://www.nela.org.uk/</ext-link>.</citation></ref>
<ref id="B3"><label>3.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Harris</surname><given-names>AHS</given-names></name><name><surname>Trickey</surname><given-names>AW</given-names></name><name><surname>Eddington</surname><given-names>HS</given-names></name><name><surname>Seib</surname><given-names>CD</given-names></name><name><surname>Kamal</surname><given-names>RN</given-names></name><name><surname>Kuo</surname><given-names>AC</given-names></name><etal/></person-group> <article-title>A tool to estimate risk of 30-day mortality and complications after hip fracture surgery: accurate enough for some but not all purposes? A study from the ACS-NSQIP database</article-title>. <source>Clin Orthop Relat Res</source>. (<year>2022</year>) <volume>480</volume>(<issue>12</issue>):<fpage>2335</fpage>&#x2013;<lpage>46</lpage>. <pub-id pub-id-type="doi">10.1097/CORR.0000000000002294</pub-id><pub-id pub-id-type="pmid">35901441</pub-id></citation></ref>
<ref id="B4"><label>4.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Costa</surname><given-names>G</given-names></name><name><surname>Bersigotti</surname><given-names>L</given-names></name><name><surname>Massa</surname><given-names>G</given-names></name><name><surname>Lepre</surname><given-names>L</given-names></name><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>Lucarini</surname><given-names>A</given-names></name><etal/></person-group> <article-title>The Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery</article-title>. <source>Aging Clin Exp Res</source>. (<year>2021</year>) <volume>33</volume>(8):<fpage>2191&#x2013;201</fpage>. <pub-id pub-id-type="doi">10.1007/s40520-020-01735-5</pub-id></citation></ref>
<ref id="B5"><label>5.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Xie</surname><given-names>F</given-names></name><name><surname>Ong</surname><given-names>MEH</given-names></name><name><surname>Liew</surname><given-names>JNMH</given-names></name><name><surname>Tan</surname><given-names>KBK</given-names></name><name><surname>Ho</surname><given-names>AFW</given-names></name><name><surname>Nadarajan</surname><given-names>GD</given-names></name><etal/></person-group> <article-title>Development and assessment of an interpretable machine learning triage tool for estimating mortality after emergency admissions</article-title>. <source>JAMA Netw Open</source>. (<year>2021</year>) <volume>4</volume>(<issue>8</issue>):<fpage>e2118467</fpage>. <pub-id pub-id-type="doi">10.1001/jamanetworkopen.2021.18467</pub-id><pub-id pub-id-type="pmid">34448870</pub-id></citation></ref>
<ref id="B6"><label>6.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ceresoli</surname><given-names>M</given-names></name><name><surname>Biloslavo</surname><given-names>A</given-names></name><name><surname>Bisagni</surname><given-names>P</given-names></name><name><surname>Ciuffa</surname><given-names>C</given-names></name><name><surname>Fortuna</surname><given-names>L</given-names></name><name><surname>La Greca</surname><given-names>A</given-names></name><etal/></person-group> <article-title>Implementing enhanced perioperative care in emergency general surgery: a prospective multicenter observational study</article-title>. <source>World J Surg</source>. (<year>2023</year>) <volume>47</volume>(<issue>6</issue>):<fpage>1339</fpage>&#x2013;<lpage>47</lpage>. <pub-id pub-id-type="doi">10.1007/s00268-023-06984-9</pub-id><pub-id pub-id-type="pmid">37024758</pub-id></citation></ref>
<ref id="B7"><label>7.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Clavien</surname><given-names>PA</given-names></name><name><surname>Barkun</surname><given-names>J</given-names></name><name><surname>de Oliveira</surname><given-names>ML</given-names></name><name><surname>Vauthey</surname><given-names>JN</given-names></name><name><surname>Dindo</surname><given-names>D</given-names></name><name><surname>Schulick</surname><given-names>RD</given-names></name><etal/></person-group> <article-title>The Clavien-Dindo classification of surgical complications: five-year experience</article-title>. <source>Ann Surg</source>. (<year>2009</year>) <volume>250</volume>(<issue>2</issue>):<fpage>187</fpage>&#x2013;<lpage>96</lpage>. <pub-id pub-id-type="doi">10.1097/SLA.0b013e3181b13ca2</pub-id><pub-id pub-id-type="pmid">19638912</pub-id></citation></ref>
<ref id="B8"><label>8.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>Fransvea</surname><given-names>G</given-names></name><name><surname>Liuzzi</surname><given-names>P</given-names></name><name><surname>Sganga</surname><given-names>G</given-names></name><name><surname>Mannini</surname><given-names>A</given-names></name><name><surname>Costa</surname><given-names>G</given-names></name></person-group>. <article-title>Study and validation of an explainable machine learning-based mortality prediction following emergency surgery in the elderly: a prospective observational study</article-title>. <source>Int J Surg</source>. (<year>2022</year>) <volume>107</volume>:<fpage>106954</fpage>. <pub-id pub-id-type="doi">10.1016/j.ijsu.2022.106954</pub-id><pub-id pub-id-type="pmid">36229017</pub-id></citation></ref>
<ref id="B9"><label>9.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>De Simone</surname><given-names>B</given-names></name><name><surname>Kluger</surname><given-names>Y</given-names></name><name><surname>Moore</surname><given-names>EE</given-names></name><etal/></person-group> <article-title>The new timing in acute care surgery (new TACS) classification: a WSES delphi consensus study</article-title>. <source>World J Emerg Surg</source>. (<year>2023</year>) <volume>18</volume>(<issue>1</issue>):<fpage>32</fpage>. <pub-id pub-id-type="doi">10.1186/s13017-023-00499-3</pub-id><pub-id pub-id-type="pmid">37118816</pub-id></citation></ref>
<ref id="B10"><label>10.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>Di Grezia</surname><given-names>M</given-names></name><name><surname>La Greca</surname><given-names>A</given-names></name><name><surname>Cozza</surname><given-names>V</given-names></name><name><surname>Sganga</surname><given-names>G</given-names></name></person-group>. <article-title>Are emergency surgical patients &#x201C;collateral victims&#x201D; of COVID-19 outbreak?</article-title> <source>Injury</source>. (<year>2020</year>) <volume>51</volume>(<issue>10</issue>):<fpage>2330</fpage>&#x2013;<lpage>1</lpage>. <pub-id pub-id-type="doi">10.1016/j.injury.2020.06.038</pub-id><pub-id pub-id-type="pmid">32620330</pub-id></citation></ref>
<ref id="B11"><label>11.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cozza</surname><given-names>V</given-names></name><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>La Greca</surname><given-names>A</given-names></name><etal/></person-group> <article-title>I-ACTSS-COVID-19-the Italian acute care and trauma surgery survey for COVID-19 pandemic outbreak</article-title>. <source>Updates Surg</source>. (<year>2020</year>) <volume>72</volume>(<issue>2</issue>):<fpage>297</fpage>&#x2013;<lpage>304</lpage>. <pub-id pub-id-type="doi">10.1007/s13304-020-00832-4</pub-id><pub-id pub-id-type="pmid">32583216</pub-id></citation></ref>
<ref id="B12"><label>12.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Salminen</surname><given-names>P</given-names></name><name><surname>Tuominen</surname><given-names>R</given-names></name><name><surname>Paajanen</surname><given-names>H</given-names></name><etal/></person-group> <article-title>Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial</article-title>. <source>J Am Med Assoc</source>. (<year>2018</year>) <volume>320</volume>(<issue>12</issue>):<fpage>1259</fpage>&#x2013;<lpage>65</lpage>. <pub-id pub-id-type="doi">10.1001/jama.2018.13201</pub-id></citation></ref>
<ref id="B13"><label>13.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sippola</surname><given-names>S</given-names></name><name><surname>Haijanen</surname><given-names>J</given-names></name><name><surname>Viinikainen</surname><given-names>L</given-names></name><etal/></person-group> <article-title>Quality of life and patient satisfaction at 7-year follow-up of antibiotic therapy vs appendectomy for uncomplicated acute appendicitis: a secondary analysis of a randomized clinical trial</article-title>. <source>JAMA Surg</source>. (<year>2020</year>) <volume>155</volume>(<issue>4</issue>):<fpage>283</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1001/jamasurg.2019.6028</pub-id><pub-id pub-id-type="pmid">32074268</pub-id></citation></ref>
<ref id="B14"><label>14.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>Fico</surname><given-names>V</given-names></name><name><surname>Cozza</surname><given-names>V</given-names></name><name><surname>Costa</surname><given-names>G</given-names></name><name><surname>Lepre</surname><given-names>L</given-names></name><name><surname>Mercantini</surname><given-names>P</given-names></name><etal/></person-group> <article-title>Clinical-pathological features and treatment of acute appendicitis in the very elderly: an interim analysis of the FRAILESEL Italian multicentre prospective study</article-title>. <source>Eur J Trauma Emerg Surg</source>. (<year>2021</year>). <pub-id pub-id-type="doi">10.1007/s00068-021-01645-9</pub-id>. [Published online ahead of print]<pub-id pub-id-type="pmid">33738537</pub-id></citation></ref>
<ref id="B15"><label>15.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Podda</surname><given-names>M</given-names></name><name><surname>Cillara</surname><given-names>N</given-names></name><name><surname>Di Saverio</surname><given-names>S</given-names></name><etal/></person-group> <article-title>Antibiotics-first strategy for uncomplicated acute appendicitis in adults is associated with increased rates of peritonitis at surgery. A systematic review with meta-analysis of randomized controlled trials comparing appendectomy and non-operative management with antibiotics</article-title>. <source>Surgeon</source>. (<year>2017</year>) <volume>15</volume>(<issue>5</issue>):<fpage>303</fpage>&#x2013;<lpage>14</lpage>. <pub-id pub-id-type="doi">10.1016/j.surge.2017.02.001</pub-id><pub-id pub-id-type="pmid">28284517</pub-id></citation></ref>
<ref id="B16"><label>16.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Abu Foul</surname><given-names>S</given-names></name><name><surname>Egozi</surname><given-names>E</given-names></name><name><surname>Assalia</surname><given-names>A</given-names></name><name><surname>Kluger</surname><given-names>Y</given-names></name><name><surname>Mahajna</surname><given-names>A</given-names></name></person-group>. <article-title>Is early appendectomy in adults diagnosed with acute appendicitis mandatory? A prospective study</article-title>. <source>World J Emerg Surg</source>. (<year>2019</year>) <volume>14</volume>(<issue>2</issue>). <pub-id pub-id-type="doi">10.1186/s13017-018-0221-2</pub-id><pub-id pub-id-type="pmid">30651750</pub-id></citation></ref>
<ref id="B17"><label>17.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ditillo</surname><given-names>MF</given-names></name><name><surname>Dziura</surname><given-names>JD</given-names></name><name><surname>Rabinovici</surname><given-names>R</given-names></name></person-group>. <article-title>Is it safe to delay appendectomy in adults with acute appendicitis?</article-title> <source>Ann Surg</source>. (<year>2006</year>) <volume>244</volume>(<issue>5</issue>):<fpage>656</fpage>&#x2013;<lpage>60</lpage>. <pub-id pub-id-type="doi">10.1097/01.sla.0000231726.53487.dd</pub-id><pub-id pub-id-type="pmid">17060754</pub-id></citation></ref>
<ref id="B18"><label>18.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moller</surname><given-names>MH</given-names></name><name><surname>Adamsen</surname><given-names>S</given-names></name><name><surname>Thomsen</surname><given-names>RW</given-names></name><name><surname>Moller</surname><given-names>AM</given-names></name></person-group>. <article-title>Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review</article-title>. <source>Scand J Gastroenterol</source>. (<year>2010</year>) <volume>45</volume>:<fpage>785</fpage>&#x2013;<lpage>805</lpage>. <pub-id pub-id-type="doi">10.3109/00365521003783320</pub-id><pub-id pub-id-type="pmid">20384526</pub-id></citation></ref>
<ref id="B19"><label>19.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fransvea</surname><given-names>P</given-names></name><name><surname>Costa</surname><given-names>G</given-names></name><name><surname>Lepre</surname><given-names>L</given-names></name><etal/></person-group> <article-title>Laparoscopic repair of perforated peptic ulcer in the elderly: an interim analysis of the FRAILESEL Italian multicenter prospective cohort study</article-title>. <source>Surg Laparosc Endosc Percutan Tech</source>. (<year>2020</year>) <volume>31</volume>(<issue>1</issue>):<fpage>2</fpage>&#x2013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1097/SLE.0000000000000826</pub-id><pub-id pub-id-type="pmid">32675754</pub-id></citation></ref>
<ref id="B20"><label>20.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sivaram</surname><given-names>P</given-names></name><name><surname>Sreekumar</surname><given-names>A</given-names></name></person-group>. <article-title>Preoperative factors influencing mortality and morbidity in peptic ulcer perforation</article-title>. <source>Eur J Trauma Emerg Surg</source>. (<year>2018</year>) <volume>44</volume>:<fpage>251</fpage>&#x2013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1007/s00068-017-0777-7</pub-id><pub-id pub-id-type="pmid">28258286</pub-id></citation></ref>
<ref id="B21"><label>21.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tarasconi</surname><given-names>A</given-names></name><name><surname>Coccolini</surname><given-names>F</given-names></name><name><surname>Biffl</surname><given-names>WL</given-names></name><etal/></person-group> <article-title>Perforated and bleeding peptic ulcer: WSES guidelines</article-title>. <source>World J Emerg Surg</source>. (<year>2020</year>) <volume>15</volume>:<fpage>3</fpage>. <pub-id pub-id-type="doi">10.1186/s13017-019-0283-9</pub-id><pub-id pub-id-type="pmid">31921329</pub-id></citation></ref>
<ref id="B22"><label>22.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mayumi</surname><given-names>T</given-names></name><name><surname>Okamoto</surname><given-names>K</given-names></name><name><surname>Takada</surname><given-names>T</given-names></name><etal/></person-group> <article-title>Tokyo guidelines 2018: management bundles for acute cholangitis and cholecystitis</article-title>. <source>J Hepatobiliary Pancreat Sci</source>. (<year>2018</year>) <volume>25</volume>:<fpage>96</fpage>&#x2013;<lpage>100</lpage>. <pub-id pub-id-type="doi">10.1002/jhbp.519</pub-id><pub-id pub-id-type="pmid">29090868</pub-id></citation></ref>
<ref id="B23"><label>23.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wiggins</surname><given-names>T</given-names></name><name><surname>Markar</surname><given-names>SR</given-names></name><name><surname>MacKenzie</surname><given-names>H</given-names></name><etal/></person-group> <article-title>Optimum timing of emergency cholecystectomy for acute cholecystitis in England: population-based cohort study</article-title>. <source>Surg Endosc</source>. (<year>2019</year>) <volume>33</volume>:<fpage>2495</fpage>&#x2013;<lpage>502</lpage>. <pub-id pub-id-type="doi">10.1007/s00464-018-6537-x</pub-id><pub-id pub-id-type="pmid">30949811</pub-id></citation></ref>
<ref id="B24"><label>24.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Yokoe</surname><given-names>M</given-names></name><name><surname>Hata</surname><given-names>J</given-names></name><name><surname>Takada</surname><given-names>T</given-names></name><etal/></person-group> <article-title>Tokyo guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos)</article-title>. <source>J Hepatobiliary Pancreat Sci</source>. (<year>2018</year>) <volume>25</volume>(<issue>1</issue>):<fpage>41</fpage>&#x2013;<lpage>54</lpage>. <pub-id pub-id-type="doi">10.1002/jhbp.515</pub-id><pub-id pub-id-type="pmid">29032636</pub-id></citation></ref>
<ref id="B25"><label>25.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pisano</surname><given-names>M</given-names></name><name><surname>Allievi</surname><given-names>N</given-names></name><name><surname>Gurusamy</surname><given-names>K</given-names></name><etal/></person-group> <article-title>2020 World society of emergency surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis</article-title>. <source>World J Emerg Surg</source>. (<year>2020</year>) <volume>15</volume>(<issue>1</issue>):<fpage>61</fpage>. <pub-id pub-id-type="doi">10.1186/s13017-020-00336-x</pub-id><pub-id pub-id-type="pmid">33153472</pub-id></citation></ref>
<ref id="B26"><label>26.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Simunovic</surname><given-names>N</given-names></name><name><surname>Devereaux</surname><given-names>PJ</given-names></name><name><surname>Sprague</surname><given-names>S</given-names></name><name><surname>Guyatt</surname><given-names>GH</given-names></name><name><surname>Schemitsch</surname><given-names>E</given-names></name><name><surname>Debeer</surname><given-names>J</given-names></name><etal/></person-group> <article-title>Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis</article-title>. <source>Can Med Assoc J</source>. (<year>2010</year>) <volume>182</volume>(<issue>15</issue>):<fpage>1609</fpage>&#x2013;<lpage>16</lpage>. <pub-id pub-id-type="doi">10.1503/cmaj.092220</pub-id></citation></ref>
<ref id="B27"><label>27.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moja</surname><given-names>L</given-names></name><name><surname>Piatti</surname><given-names>A</given-names></name><name><surname>Pecoraro</surname><given-names>V</given-names></name><name><surname>Ricci</surname><given-names>C</given-names></name><name><surname>Virgili</surname><given-names>G</given-names></name><name><surname>Salanti</surname><given-names>G</given-names></name><etal/></person-group> <article-title>Timing matters in hip fracture surgery: patients operated within 48 h have better outcomes. A meta-analysis and meta-regression of over 190,000 patients</article-title>. <source>PLoS One</source>. (<year>2012</year>) <volume>7</volume>(<issue>10</issue>):<fpage>e46175</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0046175</pub-id><pub-id pub-id-type="pmid">23056256</pub-id></citation></ref>
<ref id="B28"><label>28.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wibring</surname><given-names>K</given-names></name><name><surname>Magnusson</surname><given-names>C</given-names></name><name><surname>Axelsson</surname><given-names>C</given-names></name><name><surname>Lundgren</surname><given-names>P</given-names></name><name><surname>Herlitz</surname><given-names>J</given-names></name><name><surname>Andersson Hagiwara</surname><given-names>M</given-names></name></person-group>. <article-title>Towards definitions of time-sensitive conditions in prehospital care</article-title>. <source>Scand J Trauma Resusc Emerg Med</source>. (<year>2020</year>) <volume>28</volume>(<issue>1</issue>):<fpage>7</fpage>. <pub-id pub-id-type="doi">10.1186/s13049-020-0706-3</pub-id><pub-id pub-id-type="pmid">31996233</pub-id></citation></ref>
<ref id="B29"><label>29.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Farquharson</surname><given-names>B</given-names></name><name><surname>Abhyankar</surname><given-names>P</given-names></name><name><surname>Smith</surname><given-names>K</given-names></name><name><surname>Dombrowski</surname><given-names>SU</given-names></name><name><surname>Treweek</surname><given-names>S</given-names></name><name><surname>Dougall</surname><given-names>N</given-names></name><etal/></person-group> <article-title>Reducing delay in patients with acute coronary syndrome and other time-critical conditions: a systematic review to identify the behaviour change techniques associated with effective interventions</article-title>. <source>Open Heart</source>. (<year>2019</year>) 6(1):e000975. <pub-id pub-id-type="doi">10.1136/openhrt-2018-000975</pub-id><pub-id pub-id-type="pmid">30997136</pub-id></citation></ref>
<ref id="B30"><label>30.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Carr</surname><given-names>BG</given-names></name><name><surname>Matthew Edwards</surname><given-names>J</given-names></name><name><surname>Martinez</surname><given-names>R</given-names></name></person-group>. <article-title>Regionalized care for time-critical conditions: lessons learned from existing networks</article-title>. <source>Acad Emerg Med</source>. (<year>2010</year>) <volume>17</volume>:<fpage>1354</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1111/j.1553-2712.2010.00940.x</pub-id><pub-id pub-id-type="pmid">21122020</pub-id></citation></ref>
<ref id="B31"><label>31.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Boggi</surname><given-names>U</given-names></name></person-group>. <article-title>Precision surgery</article-title>. <source>Updates Surg</source>. (<year>2023</year>) <volume>75</volume>(<issue>1</issue>):<fpage>3</fpage>&#x2013;<lpage>5</lpage>. <pub-id pub-id-type="doi">10.1007/s13304-022-01447-7</pub-id><pub-id pub-id-type="pmid">36576702</pub-id></citation></ref>
<ref id="B32"><label>32.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bisagni</surname><given-names>P</given-names></name><name><surname>Zago</surname><given-names>M</given-names></name></person-group>. <article-title>How to deal with acute care and precision surgery: should acute care surgery be precision surgery too?</article-title> <source>Updates Surg</source>. (<year>2023</year>). <pub-id pub-id-type="doi">10.1007/s13304-023-01493-9</pub-id></citation></ref></ref-list>
</back>
</article>