AUTHOR=Zhang Xinmeng , Wang Dongmei , Song Qingqing , Luo Xin , Ge Yubin , Shen Peixin , Song Qipeng 

TITLE=Effects of tDCS combined with TENS in relieving pain and improving gait patterns during stepping over obstacles among older adults with knee osteoarthritis

JOURNAL=Frontiers in Sports and Active Living

VOLUME=Volume 7 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2025.1631357

DOI=10.3389/fspor.2025.1631357

ISSN=2624-9367

ABSTRACT=PurposeOlder adults with knee osteoarthritis (KOA) exhibit an elevated risk of falls during obstacle negotiation, primarily due to pain-induced gait deviations. While transcutaneous electrical nerve stimulation (TENS) offers modest pain relief and limited gait modulation, combining it with transcranial direct current stimulation (tDCS) may enhance the effects. This study evaluated the comparative efficacy of tDCS + TENS vs. TENS alone in mitigating pain and optimizing gait patterns during obstacle crossing in older adults with KOA.MethodsTwenty-three participants with KOA (mean age: 67.6 ± 5.0 years; BMI: 25.9 ± 2.4 kg/m2) were randomized to either tDCS + TENS (n = 12; 7F/5M) or TENS-only (n = 11; 7F/4M) groups. Both interventions involved 20-minute sessions, administered thrice weekly for six weeks. Outcome measures included pain intensity (visual analog scale, VAS) and gait variables (foot clearance height, crossing velocity) assessed pre- (week 0) and post-intervention (week 7). Data were analyzed using mixed-design two-way ANOVAs with Bonferroni corrections.ResultsStatistically significant group-by-time interactions were observed for pain (p = 0.002, η2p = 0.378), foot clearance (p = 0.038, η2p = 0.190), and crossing velocity (p < 0.001, η2p = 0.588). post hoc analyses revealed that the tDCS + TENS group (week0 = 4.72 ± 1.01, week7 = 1.98 ± 0.88, p < 0.001) experienced significantly greater reductions in pain scores compared to the TENS-only group (week0 = 5.02 ± 1.19, week7 = 3.56 ± 1.18, p < 0.001); tDCS + TENS group experienced significantly greater improvements in foot clearance (week0 = 0.19 ± 0.04, week7 = 0.20 ± 0.03, p < 0.001) and crossing velocity (week0 = 0.53 ± 0.11, week7 = 0.62 ± 0.08, p < 0.001), compared to the TENS-only group (week0 = 0.17 ± 0.02, week7 = 0.17 ± 0.02, p < 0.001; week0 = 0.52 ± 0.09, week7 = 0.54 ± 0.09).ConclusionThe combination of tDCS and TENS significantly outperformed TENS-only in reducing pain and enhancing gait adaptability during obstacle negotiation in older adults with KOA. These findings support the integration of tDCS as an adjunctive neuromodulatory strategy to amplify the therapeutic benefits of TENS in this population.