AUTHOR=Al Ghamdi Yasser Hamdan , Alawad Saud Hussain , Karem Fayka , Alsaadi Mohammed J. 

TITLE=Fibrolipomatous hamartoma of the sciatic nerve: an atypical case report

JOURNAL=Frontiers in Radiology

VOLUME=Volume 5 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/radiology/articles/10.3389/fradi.2025.1663742

DOI=10.3389/fradi.2025.1663742

ISSN=2673-8740

ABSTRACT=Fibrolipomatous hamartoma is a rare benign overgrowth of tissue consisting of intermixed adipose and fibrous connective tissue within the epineurium. However, involvement of the sciatic nerve is exceptionally rare. We present the case of a 46-year-old female who exhibited a progressively enlarging mass in her right posterior thigh, accompanied by sciatica and gluteal pain. Clinical assessment and MRI revealed a large lesion along the sciatic nerve with characteristic features of fibrolipomatous hamartoma. MRI findings demonstrated characteristic features, including isointense (to fat) on T1-weighted images and hyperintense with fat suppression on short tau inversion recovery sequences, indicating a sciatic nerve fibrolipomatous hamartoma. The diagnosis was histopathologically confirmed following surgical excision. This case highlights the critical role of identifying specific MRI features of this rare entity to avoid unnecessary invasive interventional procedures. An accurate MRI-based diagnosis can significantly impact clinical decisions and improve patient care.