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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title-group>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2296-2565</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2026.1733074</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Effectiveness of enhanced supervision, health education and environmental improvement interventions for injuries among children aged 6&#x2013;17 in Shijiazhuang</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Qiwei</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3241197"/>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Gao</surname>
<given-names>Cong</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhang</surname>
<given-names>Huichao</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Duan</surname>
<given-names>Yufan</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Deng</surname>
<given-names>Xiao</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Geng</surname>
<given-names>Danping</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &#x0026; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &#x0026; editing</role>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Ma</surname>
<given-names>Xinyan</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
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</contrib>
</contrib-group>
<aff id="aff1"><label>1</label><institution>School of Public Health, Hebei Medical University</institution>, <city>Shijiazhuang</city>, <country country="cn">China</country></aff>
<aff id="aff2"><label>2</label><institution>Shijiazhang Center for Disease Control and Prevention</institution>, <city>Shijiazhang</city>, <country country="cn">China</country></aff>
<aff id="aff3"><label>3</label><institution>National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, <city>Beijing</city>, <country country="cn">China</country></aff>
<author-notes>
<corresp id="c001"><label>&#x002A;</label>Correspondence: Xinyan Ma, <email xlink:href="mailto:xinyanmacn@hotmail.com">xinyanmacn@hotmail.com</email></corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-02-20">
<day>20</day>
<month>02</month>
<year>2026</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2026</year>
</pub-date>
<volume>14</volume>
<elocation-id>1733074</elocation-id>
<history>
<date date-type="received">
<day>27</day>
<month>10</month>
<year>2025</year>
</date>
<date date-type="rev-recd">
<day>07</day>
<month>02</month>
<year>2026</year>
</date>
<date date-type="accepted">
<day>09</day>
<month>02</month>
<year>2026</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2026 Chen, Gao, Zhang, Duan, Deng, Geng and Ma.</copyright-statement>
<copyright-year>2026</copyright-year>
<copyright-holder>Chen, Gao, Zhang, Duan, Deng, Geng and Ma</copyright-holder>
<license>
<ali:license_ref start_date="2026-02-20">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>Injuries represent a significant public health concern, ranking as the primary cause of mortality among children in China. The 5E strategy is one of the most frequently employed strategies for injury prevention, yet the efficacy of a single prevention strategy is often eclipsed by that of a comprehensive intervention strategy. The present study employed a comprehensive intervention approach, encompassing enhanced supervision, health education and environmental improvement, to evaluate the efficacy of such interventions in preventing injuries among children aged 6&#x2013;17.</p>
</sec>
<sec>
<title>Methods</title>
<p>The study population consisted of children aged 6&#x2013;17&#x202F;years. A stratified cluster sampling method was adopted to select 6 primary schools, 6 junior schools, and 4 senior high schools from Yuanshi County and Lingshou County respectively, which were then randomly assigned to the intervention group and the control group. The intervention group received a one-year comprehensive injury prevention intervention (January to December 2019), included team-based efforts to strengthen child supervision, with daily visits during school days and weekly visits during holidays; monthly health education sessions on injury prevention; and biannual home-school-community environmental inspections and improvements. The control group received no intervention.</p>
</sec>
<sec>
<title>Results</title>
<p>The intervention group showed a 0.13% decrease in injury incidence following the intervention, while the control group exhibited a 2.00% increase in injury incidence during follow-up compared to baseline. Analysis using the difference-in-differences method indicated that the intervention reduced injury incidence by 2.13% (95% CI: [0.506, 0.809], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). Specifically, children&#x2019;s injury-related knowledge scores increased by 2.830 points (95% CI: [2.659, 3.001], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), and their injury-related protective behavior scores improved by 4.573 points (95% CI: [4.308, 4.839], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). For parents, injury-related knowledge scores rose by 3.076 points (95% CI:[2.804, 3.347], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), and their injury-related protective behavior scores increased by 1.358 points (95% CI: [0.543, 2.174], <italic>p</italic>&#x202F;=&#x202F;0.001). No significant changes were observed in injury-related belief scores (children: <italic>p</italic>&#x202F;=&#x202F;0.354; parents: <italic>p</italic>&#x202F;=&#x202F;0.576) or injury-related risky behavior scores (children: <italic>p</italic>&#x202F;=&#x202F;0.961; parents: <italic>p</italic>&#x202F;=&#x202F;0.426) among either children or parents.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Interventions that integrate childcare, health education and environmental improvements shown a positive impact on the reduction of childhood injuries, the enhancement of injury prevention knowledge, and the promotion of injury prevention behaviors.</p>
</sec>
</abstract>
<kwd-group>
<kwd>child supervision</kwd>
<kwd>children</kwd>
<kwd>environmental improvement</kwd>
<kwd>health education</kwd>
<kwd>randomized controlled trial</kwd>
<kwd>unintentional injury</kwd>
</kwd-group>
<funding-group>
<funding-statement>The author(s) declared that financial support was received for this work and/or its publication. This study was supported by the grants from Scientific Research Fund Project of Hebei Provincial Health and Wellness Commission, Study on the Trends of Childhood Injury Epidemics and Technical Strategies for Prevention and Intervention (20240087) and the United Nations Children&#x2019;s Fund for Children.</funding-statement>
</funding-group>
<counts>
<fig-count count="3"/>
<table-count count="4"/>
<equation-count count="2"/>
<ref-count count="26"/>
<page-count count="10"/>
<word-count count="6148"/>
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<custom-meta-group>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Injury Prevention and Control</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec id="sec1">
<label>1</label>
<title>Background</title>
<p>Unintentional injury has emerged as a critical public health challenge worldwide, primarily attributed to its status as the leading contributor to mortality among children and adolescents (<xref ref-type="bibr" rid="ref1">1</xref>, <xref ref-type="bibr" rid="ref2">2</xref>). Beyond the profound health impacts, it also inflicts substantial disease burden and economic strain on governments, communities, and individual families (<xref ref-type="bibr" rid="ref3">3</xref>). In China, injury ranks first as the cause of death for children and adolescents aged 1&#x2013;19&#x202F;years (<xref ref-type="bibr" rid="ref4">4</xref>). According to official statistics, the child injury mortality rate in 2021 was 10.28 per 100,000, representing a 7.1% reduction compared with the prior year (<xref ref-type="bibr" rid="ref5">5</xref>). While time-series studies have documented a gradual downward trend in the incidence and mortality of childhood unintentional injuries (<xref ref-type="bibr" rid="ref6">6</xref>, <xref ref-type="bibr" rid="ref7">7</xref>), the absolute burden remains significant, highlighting the urgent need for implementing targeted and effective preventive measures to further mitigate the occurrence of unintentional injuries in this population.</p>
<p>Mounting evidence indicates that unintentional injuries can be effectively prevented and managed through targeted interventions (<xref ref-type="bibr" rid="ref8">8</xref>). Globally, the 5E strategy has emerged as a standard framework for injury prevention, comprising five key components: Education, Environmental modification, Enforcement of safety regulations, Engineering improvements, and Evaluation of intervention outcomes. Among these, educational interventions are the most frequently implemented. For instance, Moore et al. (<xref ref-type="bibr" rid="ref9">9</xref>) enhanced parental knowledge of burn first aid through educational video-based interventions, and Feng et al. (<xref ref-type="bibr" rid="ref10">10</xref>) successfully reduced injury risks in children aged 0&#x2013;3&#x202F;years by providing parent-focused educational programs via social networking platforms. Beyond education, environmental modifications have been shown to improve safety: household environmental upgrades enhance home safety (<xref ref-type="bibr" rid="ref11 ref12 ref13">11&#x2013;13</xref>), and road infrastructure improvements significantly decrease traffic injury rates (<xref ref-type="bibr" rid="ref14">14</xref>). Additionally, legislation and stricter enforcement are widely acknowledged as critical and effective tools for injury prevention and control. Niu et al. (<xref ref-type="bibr" rid="ref15">15</xref>) found that 98.5% of participants perceived legislation as a key driver for increasing child safety seat utilization and reducing traffic injuries; similarly, Shafiq et al. (<xref ref-type="bibr" rid="ref16">16</xref>) reported that 34.2% of Malaysian parents endorsed legislative mandates for Child Restraint System (CRS) use. Despite the proven efficacy of individual 5E components, the multifactorial etiology of injuries means that single-strategy interventions typically produce modest or inconsistent effects, highlighting the need for comprehensive, multi-component approaches.</p>
<p>As a foundational theoretical framework for health behavior interventions, the Knowledge-Attitude-Behavior (KAP) model has been widely adopted as a critical tool in global child injury prevention research. By constructing a logical chain that connects knowledge acquisition, attitude transformation, and behavioral adoption, the model offers robust scientific rationale for designing interventions to reduce childhood injury rates. Drawing on this theoretical basis, the present study integrated the KAP model into child injury prevention interventions. First, we assessed the baseline status of injury prevention KAP among 6-17-year-old children. Subsequently, we implemented targeted, multi-component comprehensive interventions, including strengthened child supervision, tailored health education programs, and environmental improvement initiatives. We further evaluated the intervention effectiveness across different age subgroups. The primary objectives of this study are to enhance children&#x2019;s injury prevention knowledge, positive attitudes, and protective behaviors; reduce the overall childhood injury incidence rate; and provide empirical evidence to inform the formulation of targeted child injury prevention policies and practice guidelines.</p>
</sec>
<sec sec-type="methods" id="sec2">
<label>2</label>
<title>Methods</title>
<sec id="sec3">
<label>2.1</label>
<title>Study design</title>
<p>This study was carried out in Yuanshi and Lingshou counties of Shijiazhuang City, Hebei Province, China. The two counties are comparable in geographical size, economic development level, infrastructure conditions, and other essential indicators.</p>
<p>Phase one involved conducting baseline surveys on injury incidence and injury prevention KAP among children aged 6&#x2013;17&#x202F;years in both counties from January to August 2018. Phase two implemented a one-year (January to December 2019) comprehensive child injury intervention program. Phase three involved conducting a follow-up survey (March 2020 to December 2022) to reassess injury incidence rates and KAP regarding injury prevention among the same target population, thereby evaluating the effectiveness of the comprehensive injury prevention intervention.</p>
</sec>
<sec id="sec4">
<label>2.2</label>
<title>Sample size</title>
<p>Using PASS 11.0 software, select the formula &#x201C;Tests for two proportions in a cluster-randomized design&#x201D; to estimate the sample size. Specific parameter settings are as follows: significance level <italic>&#x03B1;</italic>&#x202F;=&#x202F;0.05, statistical power 1&#x202F;&#x2212;&#x202F;<italic>&#x03B2;</italic>&#x202F;=&#x202F;0.8; set the number of participants in each intervention and control group to 600, with an equal number of groups in both intervention and control groups. Based on prior research, the estimated injury incidence rate in the control group is 16.5% (<xref ref-type="bibr" rid="ref17">17</xref>), and the estimated injury incidence rate in the intervention group after implementation is 8.0%; the intraclass correlation coefficient (ICC) is 0.03 (<xref ref-type="bibr" rid="ref18">18</xref>). The final calculation indicates that 16 groups of 600 participants each are required for both the intervention and control groups, totaling 9,600 participants. Accounting for a 10% dropout rate, the required sample size is 10,667 participants.</p>
</sec>
<sec id="sec5">
<label>2.3</label>
<title>Participants</title>
<p>The selection of children followed specific inclusion and exclusion criteria. The inclusion criteria were: (1) aged between 6 and 17&#x202F;years; (2) permanent residents of intervention or control counties; (3) able to read; (4) willing to sign written informed consent and participate in the study. The exclusion criteria were: (1) children with disabilities; (2) unable to read; (3) unwilling to sign informed consent.</p>
</sec>
<sec id="sec6">
<label>2.4</label>
<title>Randomization</title>
<p>Participants were stratified by educational stage into primary, junior, and senior high school students. Schools were designated as the cluster sampling units for each educational stratum. Prior to sampling, all eligible schools in Yuanshi County and Lingshou County were coded with unique identifiers. A random number table method was employed to randomly select 6 primary schools, 6 junior high schools, and 4 senior high schools from each county. The selected schools were then randomly assigned to either the intervention group or the control group to ensure baseline comparability between groups. Baseline enrollment included 11,797 children. Follow-up analysis included 10,616 participants, with a loss to follow-up rate of 10%.</p>
</sec>
<sec id="sec7">
<label>2.5</label>
<title>Interventions</title>
<sec id="sec8">
<label>2.5.1</label>
<title>Parent-led supervision of children&#x2019;s participation</title>
<p>The school established a dual-tier supervision system to prevent childhood injuries both on campus and during holidays. Within school premises, injury supervision teams were formed at the class group level, with pupils taking turns to patrol during breaks each day to monitor hazardous behaviors that could lead to falls. During the summer holidays, in collaboration with village committees, injury supervision volunteer teams were formed based on pupils&#x2019; residential areas. Parents served as team leaders, guiding pupils to monitor dangerous behaviors such as falls and road traffic injuries on a weekly basis, with feedback on supervision outcomes provided to teaching staff. The intervention was implemented from January to December 2019.</p>
</sec>
<sec id="sec9">
<label>2.5.2</label>
<title>School-CDC collaborative health education initiatives</title>
<p>The school conducted monthly safety and health education sessions focusing on preventing common childhood injuries such as falls, burns and scalds, and road traffic injuries. Each session lasted no &#x003C;1&#x202F;h and was delivered by trained teaching staff. Throughout each term, child safety knowledge was disseminated to parents via parent-teacher meetings and parent WeChat groups. Utilizing the official WeChat public accounts of Shijiazhuang CDC and Yuanshi County CDC, monthly articles promoting child injury prevention knowledge were published. Interactive prize-winning quizzes on injury prevention knowledge were conducted biannually. The intervention was implemented from January to December 2019.</p>
</sec>
<sec id="sec10">
<label>2.5.3</label>
<title>Child-centered hazardous environment remediation</title>
<p>Health advisers comprising CDC and township staff organized parents to conduct home hazard identification and modification activities using household screening checklists. These identify risks such as falls and scalding injuries, providing guidance for modifications with annual intervention frequency. Schools employed trained teachers to conduct campus hazard assessments using screening checklists at a frequency of once per term. Findings were relayed to relevant personnel for modifications and posting of warning notices. Community hazard identification relied on holiday injury surveillance volunteer teams conducting child-perspective hazard environment photography activities to identify injury-related risks. <xref rid="SM1" ref-type="supplementary-material">Supplementary Tables S1, S2</xref> outlines the checklist items.</p>
</sec>
</sec>
<sec id="sec11">
<label>2.6</label>
<title>Outcome measures</title>
<sec id="sec12">
<label>2.6.1</label>
<title>Primary outcome</title>
<p>The primary outcome was the incidence rate of unintentional injuries among children and adolescents in the 12&#x202F;months prior to the distribution of the questionnaire. An injury event is defined as an occurrence that meets any of the following criteria: The child received medical treatment and was diagnosed with a specific type of injury; The child was absent from work, school, or rest for more than 1&#x202F;day due to injury (<xref ref-type="bibr" rid="ref19">19</xref>).</p>
</sec>
<sec id="sec13">
<label>2.6.2</label>
<title>Secondary outcome</title>
<p>Secondary outcome measures include injury prevention KAP scores, with separate questionnaires designed for parents and children. Given cognitive limitations among children in grades 1&#x2013;3 of primary school, who may struggle to accurately comprehend questionnaire content and possess insufficient memory and recall abilities, parent-completed versions ensure higher reliability. Children in grade 4 of primary school and above, as research subjects, must complete the questionnaires independently. <xref rid="SM1" ref-type="supplementary-material">Supplementary Tables S3, S4</xref> list questionnaire items. For injury prevention knowledge and belief items, correct responses receive one point, while incorrect responses receive zero points. Injury-related behaviors are categorized into protective behaviors and risky behaviors, both scored based on frequency of occurrence (never&#x2014;1, rarely&#x2014;2, sometimes&#x2014;3, often&#x2014;4, always&#x2014;5, not applicable&#x2014;0). Higher scores are desirable for protective behaviors, while lower scores are desirable for risk behaviors.</p>
</sec>
</sec>
<sec id="sec14">
<label>2.7</label>
<title>Statistical analysis</title>
<p>Statistical analysis was performed using SPSS 25.0 software. Categorical variables were analyzed using the chi-square tests, while continuous variables (means&#x202F;&#x00B1;&#x202F;standard deviation) were compared between groups using the <italic>t</italic>-tests. Injury occurrence was treated as a binary outcome variable (assigned values: 0&#x202F;=&#x202F;no injury, 1&#x202F;=&#x202F;injury). The frequency and percentage of injury incidence among children in both groups at baseline and during follow-up were described. A mixed-effects logistic regression model was employed to analyze changes in injury incidence rates between the intervention group and the control group before and after the intervention. The model was constructed as follows:</p>
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<mml:msub>
<mml:mi mathvariant="normal">X</mml:mi>
<mml:mi>it</mml:mi>
</mml:msub>
<mml:mo>+</mml:mo>
<mml:msub>
<mml:mi>&#x03B5;</mml:mi>
<mml:mi>it</mml:mi>
</mml:msub>
</mml:mtd>
</mml:mtr>
</mml:mtable>
</mml:math>
</disp-formula>
<p>Changes in KAP scores between the intervention and control groups before and after the intervention were analyzed using a difference-in-differences (DID) model. The model is constructed as follows:</p>
<disp-formula id="E2">
<mml:math id="M2">
<mml:msub>
<mml:mi>Y</mml:mi>
<mml:mi>i</mml:mi>
</mml:msub>
<mml:mo>=</mml:mo>
<mml:msub>
<mml:mi>&#x03B2;</mml:mi>
<mml:mn>0</mml:mn>
</mml:msub>
<mml:mo>+</mml:mo>
<mml:msub>
<mml:mi>&#x03B2;</mml:mi>
<mml:mn>1</mml:mn>
</mml:msub>
<mml:mtext mathvariant="italic">Treat</mml:mtext>
<mml:mo>+</mml:mo>
<mml:msub>
<mml:mi>&#x03B2;</mml:mi>
<mml:mn>2</mml:mn>
</mml:msub>
<mml:mtext mathvariant="italic">Post</mml:mtext>
<mml:mo>+</mml:mo>
<mml:msub>
<mml:mi>&#x03B2;</mml:mi>
<mml:mn>3</mml:mn>
</mml:msub>
<mml:mo stretchy="true">(</mml:mo>
<mml:mtext mathvariant="italic">Trea</mml:mtext>
<mml:msub>
<mml:mi>t</mml:mi>
<mml:mi>i</mml:mi>
</mml:msub>
<mml:mo>&#x00D7;</mml:mo>
<mml:mi mathvariant="italic">Pos</mml:mi>
<mml:msub>
<mml:mi>t</mml:mi>
<mml:mi>t</mml:mi>
</mml:msub>
<mml:mo stretchy="true">)</mml:mo>
<mml:mo>+</mml:mo>
<mml:msub>
<mml:mi>&#x03B2;</mml:mi>
<mml:mn>4</mml:mn>
</mml:msub>
<mml:msub>
<mml:mi>X</mml:mi>
<mml:mi>i</mml:mi>
</mml:msub>
<mml:mo>+</mml:mo>
<mml:msub>
<mml:mi>&#x03B5;</mml:mi>
<mml:mi mathvariant="italic">it</mml:mi>
</mml:msub>
</mml:math>
</disp-formula>
<p>Wherein, <italic>Y<sub>it</sub></italic> represents the KAP score of the <italic>i</italic>-th subject at time <italic>t</italic>; <italic>Treat<sub>i</sub></italic> is the group variable (intervention group&#x202F;=&#x202F;1, control group&#x202F;=&#x202F;0); <italic>Post<sub>t</sub></italic> is a time variable (post-intervention&#x202F;=&#x202F;1, pre-intervention&#x202F;=&#x202F;0); <italic>Treat<sub>i</sub> &#x00D7;&#x202F;Post<sub>t</sub></italic> represents the interaction term, with <italic>&#x03B2;<sub>4</sub></italic> as its coefficient, indicating the net effect of the intervention; <italic>X<sub>it</sub></italic> denotes the covariate (child&#x2019;s gender) to control confounding factors. The t-test was used to judge the significance of coefficient.</p>
</sec>
</sec>
<sec sec-type="results" id="sec15">
<label>3</label>
<title>Results</title>
<sec id="sec16">
<label>3.1</label>
<title>Socio-demographic characteristics</title>
<p>At baseline, we collected 11,797 valid questionnaires which included 6,067 in intervention group and 5,730 in control group. For the follow-up survey, we collected 10,616 valid questionnaires, including 5,891 in intervention group and 4,725 in control group. <xref ref-type="fig" rid="fig1">Figure 1</xref> presents the flow diagram.</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>Study flow diagram.</p>
</caption>
<graphic xlink:href="fpubh-14-1733074-g001.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Consort flow diagram illustrating participant progress through a study: 14800 assessed for eligibility, 3003 excluded, 11797 randomized; 6067 allocated to intervention with 176 lost to follow up, 5730 allocated to control with 1005 lost to follow up, final analysis included 5891 intervention and 4725 control participants.</alt-text>
</graphic>
</fig>
<p>This study compared the socio-demographic characteristics between intervention group and control group. There was no statistical difference in gender between the two group of children (<italic>p</italic>&#x202F;=&#x202F;0.274, <italic>p</italic>&#x202F;=&#x202F;0.078). There were significant differences in children&#x2019;s grade and age at baseline and follow-up (all <italic>p&#x202F;&#x003C;</italic> 0.001) (<xref ref-type="table" rid="tab1">Table 1</xref>).</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Socio-demographic characteristics of sample.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Variable</th>
<th align="center" valign="top" colspan="2">Baseline</th>
<th align="center" valign="top" colspan="2">Follow-up</th>
</tr>
<tr>
<th align="center" valign="top">Intervention group</th>
<th align="center" valign="top">Control group</th>
<th align="center" valign="top">Intervention group</th>
<th align="center" valign="top">Control group</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="5">Children&#x2019;s gender, <italic>n</italic> (%)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Male</td>
<td align="center" valign="top">3,120 (51.43)</td>
<td align="center" valign="top">2,889 (50.42)</td>
<td align="center" valign="top">3,035 (51.51)</td>
<td align="center" valign="top">2,353 (49.80)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Female</td>
<td align="center" valign="top">2,947 (48.57)</td>
<td align="center" valign="top">2,841 (49.58)</td>
<td align="center" valign="top">2,856 (48.47)</td>
<td align="center" valign="top">2,372 (50.20)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Chi-square values</td>
<td align="center" valign="top" colspan="2">1.195</td>
<td align="center" valign="top" colspan="2">3.105</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;<italic>p</italic>-value</td>
<td align="center" valign="top" colspan="2">0.274</td>
<td align="center" valign="top" colspan="2">0.078</td>
</tr>
<tr>
<td align="left" valign="top" colspan="5">Children&#x2019;s grade, <italic>n</italic> (%)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Grades 1&#x2013;3</td>
<td align="center" valign="top">1873 (30.87)</td>
<td align="center" valign="top">1,268 (22.13)</td>
<td align="center" valign="top">1,697 (28.81)</td>
<td align="center" valign="top">1,076 (22.77)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Grades 4&#x2013;6</td>
<td align="center" valign="top">1,506 (24.82)</td>
<td align="center" valign="top">1,032 (18.01)</td>
<td align="center" valign="top">1,506 (25.56)</td>
<td align="center" valign="top">1,032 (21.84)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Junior grades</td>
<td align="center" valign="top">1,163 (19.17)</td>
<td align="center" valign="top">2,042 (35.64)</td>
<td align="center" valign="top">1,163 (19.74)</td>
<td align="center" valign="top">1,229 (26.01)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Senior grades</td>
<td align="center" valign="top">1,525 (25.14)</td>
<td align="center" valign="top">1,388 (24.22)</td>
<td align="center" valign="top">1,525 (25.89)</td>
<td align="center" valign="top">1,388 (29.38)</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;Chi-square values</td>
<td align="center" valign="top" colspan="2">443.308</td>
<td align="center" valign="top" colspan="2">109.109</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;<italic>p</italic>-value</td>
<td align="center" valign="top" colspan="2">&#x003C;0.001</td>
<td align="center" valign="top" colspan="2">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top">Children&#x2019;s age, mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="center" valign="top">11.31&#x202F;&#x00B1;&#x202F;3.66</td>
<td align="center" valign="top">11.99&#x202F;&#x00B1;&#x202F;3.26</td>
<td align="center" valign="top">11.90&#x202F;&#x00B1;&#x202F;3.27</td>
<td align="center" valign="top">12.63&#x202F;&#x00B1;&#x202F;3.36</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;<italic>Z</italic>-value</td>
<td align="center" valign="top" colspan="2">10.782</td>
<td align="center" valign="top" colspan="2">&#x2212;12.495</td>
</tr>
<tr>
<td align="left" valign="top">&#x2003;<italic>p</italic>-value</td>
<td align="center" valign="top" colspan="2">&#x003C;0.001</td>
<td align="center" valign="top" colspan="2">&#x003C;0.001</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>SD, standard deviation.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec17">
<label>3.2</label>
<title>Unintentional injury incidence</title>
<p>As shown in <xref ref-type="table" rid="tab2">Table 2</xref>, the unintentional injury incidence in the intervention group decreased non-significantly from the baseline of 5.82% to the follow-up of 5.69% (<italic>&#x03C7;<sup>2</sup></italic>&#x202F;=&#x202F;0.096, <italic>p</italic>&#x202F;=&#x202F;0.757), but the injury incidence in the control group increased significantly from 4.07 to 6.07% (<italic>&#x03C7;<sup>2</sup></italic>&#x202F;=&#x202F;22.087, <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). The change in injury incidence rate was &#x2212;0.13% in the intervention group and 2.00% in the control group. Calculated using the DID, the net intervention effect was &#x2212;2.13% (95% CI: [0.506, 0.809], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001).</p>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>The effectiveness of primary outcome.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Group</th>
<th align="left" valign="top">Stage</th>
<th align="center" valign="top">Injury incidence (<italic>n</italic>, %)</th>
<th align="center" valign="top">Within-group intervention effect (<italic>&#x03C7;<sup>2</sup></italic>/<italic>p</italic>)</th>
<th align="center" valign="top">
<italic>&#x03B2;<sup>a</sup></italic>
</th>
<th align="center" valign="top">95%CI</th>
<th align="center" valign="top"><italic>p</italic> value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="2">Intervention group</td>
<td align="left" valign="top">Baseline</td>
<td align="char" valign="top" char="(">353 (5.82)</td>
<td align="char" valign="top" char="/" rowspan="2">0.096/0.757</td>
<td align="char" valign="middle" char="." rowspan="4">&#x2212;0.447</td>
<td align="center" valign="middle" rowspan="4">[0.506, 0.809]</td>
<td align="char" valign="middle" char="." rowspan="4">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top">Follow-up</td>
<td align="char" valign="top" char="(">335 (5.69)</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Control group</td>
<td align="left" valign="top">Baseline</td>
<td align="char" valign="top" char="(">233 (4.07)</td>
<td align="char" valign="top" char="/" rowspan="2">22.087/&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top">Follow-up</td>
<td align="char" valign="top" char="(">287 (6.07)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><sup>a</sup>&#x03B2; is the coefficient of interaction term.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec18">
<label>3.3</label>
<title>Children&#x2019;s knowledge, beliefs, and behaviors</title>
<p>As <xref ref-type="table" rid="tab3">Table 3</xref> and <xref rid="SM1" ref-type="supplementary-material">Supplementary Table S5</xref> demonstrated, statistically significant changes were observed in the intervention group children&#x2019;s scores for injury-related knowledge, beliefs, protective behaviors, and risky behaviors both before and after the intervention (all <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). Similarly, statistically significant changes were also noted in the control group children&#x2019;s scores for knowledge (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), beliefs (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), protective behaviors (<italic>p</italic>&#x202F;=&#x202F;0.026), and risky behaviors (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). Comparing the intervention and control groups, DID analysis revealed a 2.830-point improvement in children&#x2019;s injury-related knowledge (95% CI: [2.659, 3.001], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001) and 4.573-point improvement in protective behavior (95% CI: [4.308, 4.839], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). Changes in belief scores (<italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.042, 95% CI: [&#x2212;0.132, 0.047], <italic>p</italic>&#x202F;=&#x202F;0.354) and risky behavior scores (<italic>&#x03B2;</italic>&#x202F;=&#x202F;0.008, 95% CI:[&#x2212;0.328, 0.345], <italic>p</italic>&#x202F;=&#x202F;0.961) were not statistically significant. (<xref ref-type="fig" rid="fig2">Figure 2</xref>).</p>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption>
<p>The effectiveness of children&#x2019;s secondary outcome.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Variable</th>
<th align="center" valign="top" colspan="2">Intervention group</th>
<th align="center" valign="top" colspan="2">Control group</th>
<th align="center" valign="top" rowspan="2">
<italic>&#x03B2;<sup>a</sup></italic>
</th>
<th align="center" valign="top" rowspan="2">95%CI</th>
<th align="center" valign="top" rowspan="2"><italic>p</italic> value</th>
</tr>
<tr>
<th align="center" valign="top">Baseline</th>
<th align="center" valign="top">Follow-up</th>
<th align="center" valign="top">Baseline</th>
<th align="center" valign="top">Follow-up</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" colspan="8">Injury-related knowledge, mean&#x202F;&#x00B1;&#x202F;SD</td>
</tr>
<tr>
<td align="left" valign="middle">Children</td>
<td align="char" valign="top" char="&#x00B1;">9.84 &#x00B1; 2.86</td>
<td align="char" valign="top" char="&#x00B1;">12.86 &#x00B1; 3.86</td>
<td align="char" valign="top" char="&#x00B1;">10.02&#x202F;&#x00B1;&#x202F;2.44</td>
<td align="char" valign="top" char="&#x00B1;">10.21&#x202F;&#x00B1;&#x202F;2.38</td>
<td align="char" valign="top" char=".">2.830</td>
<td align="center" valign="top">[2.659, 3.001]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Primary school</td>
<td align="char" valign="top" char="&#x00B1;">9.44 &#x00B1; 2.79</td>
<td align="char" valign="top" char="&#x00B1;">12.96 &#x00B1; 3.65</td>
<td align="char" valign="top" char="&#x00B1;">10.57&#x202F;&#x00B1;&#x202F;2.91</td>
<td align="char" valign="top" char="&#x00B1;">9.94&#x202F;&#x00B1;&#x202F;2.54</td>
<td align="char" valign="top" char=".">4.147</td>
<td align="center" valign="top">[3.821, 4.473]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Junior school</td>
<td align="char" valign="top" char="&#x00B1;">9.12 &#x00B1; 2.83</td>
<td align="char" valign="top" char="&#x00B1;">10.87 &#x00B1; 3.09</td>
<td align="char" valign="top" char="&#x00B1;">9.77&#x202F;&#x00B1;&#x202F;2.38</td>
<td align="char" valign="top" char="&#x00B1;">9.69&#x202F;&#x00B1;&#x202F;2.30</td>
<td align="char" valign="top" char=".">1.837</td>
<td align="center" valign="top">[1.565, 2.109]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Senior high school</td>
<td align="char" valign="top" char="&#x00B1;">9.02 &#x00B1; 2.67</td>
<td align="char" valign="top" char="&#x00B1;">14.88 &#x00B1; 3.68</td>
<td align="char" valign="top" char="&#x00B1;">9.99&#x202F;&#x00B1;&#x202F;2.06</td>
<td align="char" valign="top" char="&#x00B1;">10.64&#x202F;&#x00B1;&#x202F;2.24</td>
<td align="char" valign="top" char=".">5.212</td>
<td align="center" valign="top">[4.950, 5.473]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="8">Injury-related beliefs, mean&#x202F;&#x00B1;&#x202F;SD</td>
</tr>
<tr>
<td align="left" valign="middle">Children</td>
<td align="char" valign="top" char="&#x00B1;">6.80 &#x00B1; 1.82</td>
<td align="char" valign="top" char="&#x00B1;">6.97&#x202F;&#x00B1;&#x202F;1.44</td>
<td align="char" valign="top" char="&#x00B1;">7.13 &#x00B1; 1.54</td>
<td align="char" valign="top" char="&#x00B1;">7.34 &#x00B1; 1.50</td>
<td align="char" valign="top" char=".">&#x2212;0.042</td>
<td align="center" valign="top">[&#x2212;0.132, 0.047]</td>
<td align="center" valign="top">0.354</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Primary school</td>
<td align="char" valign="top" char="&#x00B1;">6.80 &#x00B1; 1.71</td>
<td align="char" valign="top" char="&#x00B1;">7.12 &#x00B1; 1.34</td>
<td align="char" valign="top" char="&#x00B1;">7.06&#x202F;&#x00B1;&#x202F;1.47</td>
<td align="char" valign="top" char="&#x00B1;">7.02&#x202F;&#x00B1;&#x202F;1.49</td>
<td align="char" valign="top" char=".">0.351</td>
<td align="center" valign="top">[0.189, 0.513]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Junior school</td>
<td align="char" valign="top" char="&#x00B1;">6.67 &#x00B1; 1.72</td>
<td align="char" valign="top" char="&#x00B1;">6.80 &#x00B1; 1.58</td>
<td align="char" valign="top" char="&#x00B1;">7.04&#x202F;&#x00B1;&#x202F;1.60</td>
<td align="char" valign="top" char="&#x00B1;">7.19&#x202F;&#x00B1;&#x202F;1.48</td>
<td align="char" valign="top" char=".">&#x2212;0.023</td>
<td align="center" valign="top">[&#x2212;0.184, 0.138]</td>
<td align="center" valign="top">0.783</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Senior high school</td>
<td align="char" valign="top" char="&#x00B1;">6.88 &#x00B1; 1.98</td>
<td align="char" valign="top" char="&#x00B1;">7.02 &#x00B1; 1.35</td>
<td align="char" valign="top" char="&#x00B1;">7.30&#x202F;&#x00B1;&#x202F;1.50</td>
<td align="char" valign="top" char="&#x00B1;">7.60&#x202F;&#x00B1;&#x202F;1.47</td>
<td align="char" valign="top" char=".">&#x2212;0.169</td>
<td align="center" valign="top">[&#x2212;0.318, &#x2212;0.020]</td>
<td align="center" valign="top">0.026</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="8">Injury-related protective behaviors, mean&#x202F;&#x00B1;&#x202F;SD</td>
</tr>
<tr>
<td align="left" valign="middle">Children</td>
<td align="char" valign="top" char="&#x00B1;">13.15 &#x00B1; 3.75</td>
<td align="char" valign="top" char="&#x00B1;">17.53&#x202F;&#x00B1;&#x202F;5.78</td>
<td align="char" valign="top" char="&#x00B1;">14.13 &#x00B1; 4.08</td>
<td align="char" valign="top" char="&#x00B1;">13.93 &#x00B1; 4.40</td>
<td align="char" valign="top" char=".">4.573</td>
<td align="center" valign="top">[4.308, 4.839]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Primary school</td>
<td align="char" valign="top" char="&#x00B1;">13.17 &#x00B1; 4.11</td>
<td align="char" valign="top" char="&#x00B1;">19.13 &#x00B1; 5.42</td>
<td align="char" valign="top" char="&#x00B1;">15.84 &#x00B1; 4.40</td>
<td align="char" valign="top" char="&#x00B1;">14.67 &#x00B1; 4.65</td>
<td align="char" valign="top" char=".">7.139</td>
<td align="center" valign="top">[6.633, 7.645]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Junior school</td>
<td align="char" valign="top" char="&#x00B1;">13.68 &#x00B1; 3.44</td>
<td align="char" valign="top" char="&#x00B1;">16.02 &#x00B1; 5.29</td>
<td align="char" valign="top" char="&#x00B1;">13.74 &#x00B1; 3.95</td>
<td align="char" valign="top" char="&#x00B1;">13.18 &#x00B1; 4.03</td>
<td align="char" valign="top" char=".">2.906</td>
<td align="center" valign="top">[2.466, 3.346]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Senior high school</td>
<td align="char" valign="top" char="&#x00B1;">12.75 &#x00B1; 3.54</td>
<td align="char" valign="top" char="&#x00B1;">17.76 &#x00B1; 6.16</td>
<td align="char" valign="top" char="&#x00B1;">13.43 &#x00B1; 3.67</td>
<td align="char" valign="top" char="&#x00B1;">13.91 &#x00B1; 4.37</td>
<td align="char" valign="top" char=".">4.540</td>
<td align="center" valign="top">[4.099, 4.980]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="8">Injury-related risky behaviors, mean&#x202F;&#x00B1;&#x202F;SD</td>
</tr>
<tr>
<td align="left" valign="middle">Children</td>
<td align="char" valign="top" char="&#x00B1;">23.68 &#x00B1; 5.95</td>
<td align="char" valign="top" char="&#x00B1;">21.74&#x202F;&#x00B1;&#x202F;5.61</td>
<td align="char" valign="top" char="&#x00B1;">24.59 &#x00B1; 6.45</td>
<td align="char" valign="top" char="&#x00B1;">22.64 &#x00B1; 5.65</td>
<td align="char" valign="top" char=".">0.008</td>
<td align="center" valign="top">[&#x2212;0.328, 0.345]</td>
<td align="center" valign="top">0.961</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Primary school</td>
<td align="char" valign="top" char="&#x00B1;">22.24 &#x00B1; 5.60</td>
<td align="char" valign="top" char="&#x00B1;">21.50 &#x00B1; 5.67</td>
<td align="char" valign="top" char="&#x00B1;">20.72 &#x00B1; 4.99</td>
<td align="char" valign="top" char="&#x00B1;">20.79 &#x00B1; 4.88</td>
<td align="char" valign="top" char=".">&#x2212;0.801</td>
<td align="center" valign="top">[&#x2212;1.374, &#x2212;0.228]</td>
<td align="center" valign="top">0.006</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Junior school</td>
<td align="char" valign="top" char="&#x00B1;">24.96 &#x00B1; 6.00</td>
<td align="char" valign="top" char="&#x00B1;">21.79 &#x00B1; 6.13</td>
<td align="char" valign="top" char="&#x00B1;">25.23 &#x00B1; 6.38</td>
<td align="char" valign="top" char="&#x00B1;">22.37 &#x00B1; 5.12</td>
<td align="char" valign="top" char=".">&#x2212;0.310</td>
<td align="center" valign="top">[&#x2212;0.918, 0.298]</td>
<td align="center" valign="top">0.318</td>
</tr>
<tr>
<td align="left" valign="middle">&#x2003;Senior high school</td>
<td align="char" valign="top" char="&#x00B1;">24.13 &#x00B1; 5.95</td>
<td align="char" valign="top" char="&#x00B1;">21.89 &#x00B1; 4.95</td>
<td align="char" valign="top" char="&#x00B1;">26.53 &#x00B1; 6.31</td>
<td align="char" valign="top" char="&#x00B1;">23.85 &#x00B1; 6.00</td>
<td align="char" valign="top" char=".">0.429</td>
<td align="center" valign="top">[&#x2212;0.121, 0.978]</td>
<td align="center" valign="top">0.126</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>SD, standard deviation. <sup>a</sup>&#x03B2; is the coefficient of interaction term.</p>
</table-wrap-foot>
</table-wrap>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>Comparison of baseline and follow-up between children in the intervention and control groups.</p>
</caption>
<graphic xlink:href="fpubh-14-1733074-g002.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Four line graphs compare intervention and control groups on children&#x2019;s injury-related knowledge, beliefs, protective behaviors, and risky behaviors from baseline to follow-up. Intervention group shows greater improvement in knowledge and protective behaviors and a steeper decline in risky behaviors, while control group shows slight improvements or smaller declines across all measures.</alt-text>
</graphic>
</fig>
<p>In terms of injury-related knowledge scores, primary school children improved by 4.147 points (95% CI: [3.821, 4.473], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), junior school children improved by 1.837 points (95% CI: [1.565, 2.109], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), and senior high school children improved by 5.212 points (95% CI: [4.950, 5.473], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). Regarding injury-related belief scores, primary school children increased by 0.351 points (95% CI: [0.1890, 0.513], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), senior high school children decreased by 0.169 points (95% CI: [&#x2212;0.318, &#x2212;0.020], <italic>p</italic>&#x202F;=&#x202F;0.026), while the change in junior school children&#x2019;s scores was not statistically significant (<italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.023, 95% CI:[&#x2212;0.184, 0.138], <italic>p</italic>&#x202F;=&#x202F;0.783).</p>
<p>Regarding children&#x2019;s injury-related protective and risky behaviors, DID analysis by grade level on changes in injury-related protective behavior scores before and after intervention revealed significant increases among primary school children (<italic>&#x03B2;</italic>&#x202F;=&#x202F;7.139, 95% CI: [6.633, 7.645], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), junior school children (<italic>&#x03B2;</italic>&#x202F;=&#x202F;2.906, 95% CI: [2.466, 3.346], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), and senior high school children (<italic>&#x03B2;</italic>&#x202F;=&#x202F;4.540, 95% CI: [4.099, 4.980], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). For injury-related risky behaviors, DID analysis showed a significant reduction in primary school children in the intervention group compared with the control group (<italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.801, 95% CI: [&#x2212;1.374, &#x2212;0.228], <italic>p</italic>&#x202F;=&#x202F;0.006), while no significant differences were found in junior school children (<italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.310, 95% CI: [&#x2212;0.918, 0.298], <italic>p</italic>&#x202F;=&#x202F;0.318) or senior high school children (<italic>&#x03B2;</italic>&#x202F;=&#x202F;0.429, 95% CI: [&#x2212;0.121, 0.978], <italic>p</italic>&#x202F;=&#x202F;0.126).</p>
</sec>
<sec id="sec19">
<label>3.4</label>
<title>Parents&#x2019; knowledge, beliefs, and behaviors</title>
<p>Regarding parents&#x2019; knowledge and beliefs about injury prevention, the intervention group had baseline mean scores of 9.75 and 8.34, which increased to 14.05 and 8.95 at follow-up, respectively; both changes were statistically significant (all <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). In the control group, baseline scores were 9.78 and 8.51, with follow-up scores of 11.01 and 9.18, respectively, and these improvements also reached statistical significance for both knowledge and beliefs (all <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). DID analysis showed a significant difference in parental injury prevention knowledge between the intervention and control groups (<italic>&#x03B2;</italic>&#x202F;=&#x202F;3.076, 95% CI: [2.804, 3.347], <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001), whereas no significant difference was observed in beliefs (<italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.061, 95% CI: [&#x2212;0.276, 0.153], <italic>p</italic>&#x202F;=&#x202F;0.576).</p>
<p>For parents&#x2019; injury-related protective and risky behaviors, the intervention group achieved baseline scores of 24.03 and 19.80, with follow-up scores of 33.14 and 19.65, respectively; all changes were statistically significant (all <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). In the control group, baseline scores were 21.54 and 19.98, and follow-up scores were 29.29 and 19.65, respectively, with significant differences found for both behaviors (all <italic>p</italic>&#x202F;&#x003C;&#x202F;0.001). According to the DID analysis results, a significant difference was noted in parental protective behaviors (<italic>&#x03B2;</italic>&#x202F;=&#x202F;1.358, 95% CI: [0.543, 2.174], <italic>p</italic>&#x202F;=&#x202F;0.001), but no significant difference existed in risky behaviors (<italic>&#x03B2;</italic>&#x202F;=&#x202F;0.180, 95% CI: [&#x2212;0.263, 0.622], <italic>p</italic>&#x202F;=&#x202F;0.426) (<xref ref-type="table" rid="tab4">Table 4</xref>; <xref ref-type="fig" rid="fig3">Figure 3</xref>).</p>
<table-wrap position="float" id="tab4">
<label>Table 4</label>
<caption>
<p>The effectiveness of parents&#x2019; secondary outcome.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Variable</th>
<th align="center" valign="top" colspan="2">Intervention group</th>
<th align="center" valign="top" colspan="2">Control group</th>
<th align="center" valign="top" rowspan="2">
<italic>&#x03B2;<sup>a</sup></italic>
</th>
<th align="center" valign="top" rowspan="2">95%CI</th>
<th align="center" valign="top" rowspan="2"><italic>p</italic> value</th>
</tr>
<tr>
<th align="center" valign="top">Baseline</th>
<th align="center" valign="top">Follow-up</th>
<th align="center" valign="top">Baseline</th>
<th align="center" valign="top">Follow-up</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">Injury-related knowledge, mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="char" valign="top" char="&#x00B1;">9.75 &#x00B1; 2.92</td>
<td align="char" valign="top" char="&#x00B1;">14.05 &#x00B1; 3.89</td>
<td align="char" valign="top" char="&#x00B1;">9.45&#x202F;&#x00B1;&#x202F;2.49</td>
<td align="char" valign="top" char="&#x00B1;">11.01 &#x00B1; 2.51</td>
<td align="char" valign="top" char=".">3.076</td>
<td align="center" valign="top">[2.804, 3.347]</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Injury-related beliefs, mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="char" valign="top" char="&#x00B1;">8.34 &#x00B1; 2.54</td>
<td align="char" valign="top" char="&#x00B1;">8.95 &#x00B1; 2.43</td>
<td align="char" valign="top" char="&#x00B1;">8.51&#x202F;&#x00B1;&#x202F;2.17</td>
<td align="char" valign="top" char="&#x00B1;">9.18 &#x00B1; 2.06</td>
<td align="char" valign="top" char=".">&#x2212;0.061</td>
<td align="center" valign="top">[&#x2212;0.276, 0.153]</td>
<td align="center" valign="top">0.576</td>
</tr>
<tr>
<td align="left" valign="middle">Injury-related protective behaviors, mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="char" valign="top" char="&#x00B1;">28.26 &#x00B1; 8.60</td>
<td align="char" valign="top" char="&#x00B1;">36.20 &#x00B1; 10.68</td>
<td align="char" valign="top" char="&#x00B1;">21.54 &#x00B1; 8.32</td>
<td align="char" valign="top" char="&#x00B1;">29.29 &#x00B1; 9.68</td>
<td align="char" valign="top" char=".">1.358</td>
<td align="center" valign="top">[0.543, 2.174]</td>
<td align="center" valign="top">0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Injury-related risky behaviors, mean&#x202F;&#x00B1;&#x202F;SD</td>
<td align="char" valign="top" char="&#x00B1;">19.80 &#x00B1; 5.01</td>
<td align="char" valign="top" char="&#x00B1;">19.65&#x202F;&#x00B1;&#x202F;4.10</td>
<td align="char" valign="top" char="&#x00B1;">19.98 &#x00B1; 4.94</td>
<td align="char" valign="top" char="&#x00B1;">19.65 &#x00B1; 4.24</td>
<td align="char" valign="top" char=".">0.180</td>
<td align="center" valign="top">[&#x2212;0.263, 0.622]</td>
<td align="center" valign="top">0.426</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>SD standard deviation. <sup>a</sup>&#x03B2; is the coefficient of interaction term.</p>
</table-wrap-foot>
</table-wrap>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>Comparison of baseline and follow-up between parents in the intervention and control groups.</p>
</caption>
<graphic xlink:href="fpubh-14-1733074-g003.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Four line charts compare intervention and control groups for parents&#x2019; injury-related knowledge, beliefs, protective behaviors, and risky behaviors from baseline to follow-up. The intervention group shows greater improvement in knowledge and protective behaviors compared to the control, similar trends in beliefs, and comparable decreases in risky behaviors.</alt-text>
</graphic>
</fig>
</sec>
</sec>
<sec sec-type="discussion" id="sec20">
<label>4</label>
<title>Discussion</title>
<p>This study employed a cluster randomized controlled trial design to demonstrate the effectiveness of integrated interventions&#x2014;combining enhanced child supervision, health education, and environmental improvement&#x2014;in reducing childhood injury rates while improving children&#x2019;s knowledge of injury prevention and their protective behaviors. However, no statistically significant difference was observed between the intervention and control groups regarding injury-related attitudes. This finding underscored the resistance of established attitudes to short-term interventions, highlighting the need for prolonged or targeted strategies to modify injury-related belief systems (<xref ref-type="bibr" rid="ref10">10</xref>, <xref ref-type="bibr" rid="ref20">20</xref>).</p>
<p>The results indicated that the incidence of injuries in the intervention group decreased by 0.13%, while that in the control group increased by 2.00%. The rise in injury incidence among the control group may be attributed to the high randomness of childhood injury events, weakened awareness of injury risks due to the absence of intervention measures, and the prolonged follow-up period that exposed participants to greater external injury risk factors, leading to a natural increase in childhood injury incidence over time. In contrast, the implementation of intervention measures in the intervention group effectively suppressed the natural upward trend of childhood injury incidence and achieved a slight decrease, exerting a positive effect on preventing injury occurrence. From the perspective of health burden, childhood injuries rank among the leading causes of disability and death in children. Even a modest reduction in injury rates can significantly decrease emergency department visits, hospital stays, and long-term health needs, thereby alleviating pressure on pediatric healthcare resources. From the economic burden perspective, a decrease in childhood injury rates can reduce medical expenses, emergency care, and rehabilitation costs associated with injuries, alleviating the financial burden on families. It also minimizes lost workdays for parents caring for injured children and reduces future labor supply gaps caused by childhood disabilities.</p>
<p>Baseline data revealed that the injury-related knowledge scores of children and their parents in both the intervention and control groups were below 60%, whereas their belief scores exceeded 60%. This finding indicates that despite insufficient injury prevention knowledge, participants held accurate beliefs and positive attitudes toward injury prevention. Following the intervention, significant improvements in knowledge scores were observed among both parents and children. High school students exhibited the greatest increase, followed by parents of students in grades 1&#x2013;3. In contrast, middle school children showed the least significant improvement in knowledge scores. The alignment between children&#x2019;s cognitive development and intervention content may influence knowledge absorption efficiency. A study conducted in Jiangsu Province reported that the pass rate of injury awareness was 90.92% among high school students, 84.45% among primary school students, and 89.42% among parents&#x2014;all higher than the 81.75% rate among junior high school students (<xref ref-type="bibr" rid="ref21">21</xref>)&#x2014;which is consistent with the findings of the present study. No substantial changes in belief scores were noted for either parents or children, with only a slight increase observed among upper primary school children (grades 4&#x2013;6). Both children and parents demonstrated increased injury prevention protective behaviors, while a reduction in risky behaviors was only observed among upper primary school children (grades 4&#x2013;6). This result is consistent with that of Mehreen et al. (<xref ref-type="bibr" rid="ref22">22</xref>), who reported that younger children showed better performance in beliefs and injury-related risky behaviors compared to older peers.</p>
<p>This study focuses on children and adolescents aged 6&#x2013;17&#x202F;years. Compared with preschool children, this age group engages in activities across a wider range of settings, including family, school, and community environments. Thus, the development and implementation of a multi-dimensional child injury intervention model centered on the family-school-community triad are imperative. In China, basic community public services have been fully rolled out (<xref ref-type="bibr" rid="ref23">23</xref>), laying a solid foundation for establishing cross-sectoral collaboration mechanisms for child injury prevention. Previous research has highlighted the critical role of parents and guardians in ensuring children&#x2019;s safety (<xref ref-type="bibr" rid="ref24">24</xref>), as their injury prevention-related knowledge, attitudes, and behaviors exert a significant influence on childhood injury risk. Therefore, for younger children, interventions were prioritized to strengthen parental engagement and capacity-building. Additionally, studies have confirmed the effectiveness of the Child-To-Child Approach in reducing childhood injuries and associated medical costs (<xref ref-type="bibr" rid="ref25">25</xref>). Accordingly, our intervention strategy also adopted a child-centered approach, actively involving children in injury risk monitoring, health education initiatives, and environmental safety modifications. Such participation directly enhances children&#x2019;s injury prevention KAP.</p>
<p>The combined interventions in this study resulted in a significant improvement in the knowledge of children and parents. The analysis of the improved knowledge scores of children of different ages suggests that, in future injury interventions, intervention toolkit should be designed to take into account the receptive and learning abilities of children of different ages, and more targeted interventions should be carried out. The present study found that injury-related beliefs and behaviors were resistant to change in the short term and were not significant in older children. These findings suggest that child injury prevention should be implemented on a long-term basis and integrated into the daily management of children&#x2019;s health (<xref ref-type="bibr" rid="ref26">26</xref>). Meanwhile, the intervention focused on modifying beliefs should be initiated among younger children to ensure optimal efficacy.</p>
<p>This study has several limitations. First, a questionnaire was used to collect data on childhood injuries occurring over the past 12&#x202F;months, which may have introduced recall bias and thus affected the findings to a certain extent. Additionally, the injury data were not disaggregated by injury type, which may have influenced the study findings to some extent. Second, although significant improvements were observed in children&#x2019;s injury prevention knowledge and protective behaviors, there was no corresponding significant reduction in childhood injury incidence. This indicates that a one-year intervention duration is insufficient to sustain long-term injury prevention effects, highlighting the need for extended intervention strategies. Third, this study did not explore the replicability of the intervention in other regions, nor did it examine the potential impacts of family background and socioeconomic factors on intervention outcomes.</p>
</sec>
<sec sec-type="conclusions" id="sec21">
<label>5</label>
<title>Conclusion</title>
<p>This integrated intervention program, implemented in Shijiazhuang City for children aged 6 to 17, encompassing comprehensive childcare, health education and environmental improvements, has yielded positive outcomes in reducing child injury rates while enhancing both children&#x2019;s and parents&#x2019; knowledge and behavioral capacity regarding injury prevention. This integrated family-school-community approach to injury prevention merits wider adoption. It overcomes the limitations of single-setting interventions, eliminates gaps in coverage, and facilitates resource complementarity, thereby enhancing the professionalism and sustainability of such programs.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="sec22">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec sec-type="ethics-statement" id="sec23">
<title>Ethics statement</title>
<p>The studies involving humans were approved by Human Ethics Committee of Shijiazhuang Center for Disease Control and Prevention. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants&#x2019; legal guardians/next of kin. The manuscript presents research on animals that do not require ethical approval for their study. Written informed consent was obtained from the individual(s), and minor(s)&#x2019; legal guardian/next of kin, for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec sec-type="author-contributions" id="sec24">
<title>Author contributions</title>
<p>QC: Formal analysis, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. XM: Conceptualization, Writing &#x2013; review &#x0026; editing. CG: Investigation, Writing &#x2013; review &#x0026; editing. HZ: Investigation, Writing &#x2013; review &#x0026; editing. YD: Investigation, Writing &#x2013; review &#x0026; editing. XD: Conceptualization, Writing &#x2013; review &#x0026; editing. DG: Writing &#x2013; review &#x0026; editing.</p>
</sec>
<ack>
<title>Acknowledgments</title>
<p>We would like to express our gratitude to the participants who participated in this study during their valuable time, and to the United Nations Children&#x2019;s Fund (UNICEF) and the National Center for Chronic Noncommunicable Disease Prevention and Control of the Chinese Center for Disease Control and Prevention for their support and guidance.</p>
</ack>
<sec sec-type="COI-statement" id="sec25">
<title>Conflict of interest</title>
<p>The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="sec26">
<title>Generative AI statement</title>
<p>The author(s) declared that Generative AI was not used in the creation of this manuscript.</p>
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<title>Publisher&#x2019;s note</title>
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</sec>
<sec sec-type="supplementary-material" id="sec28">
<title>Supplementary material</title>
<p>The Supplementary material for this article can be found online at: <ext-link xlink:href="https://www.frontiersin.org/articles/10.3389/fpubh.2026.1733074/full#supplementary-material" ext-link-type="uri">https://www.frontiersin.org/articles/10.3389/fpubh.2026.1733074/full#supplementary-material</ext-link></p>
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</sec>
<ref-list>
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<fn-group>
<fn fn-type="custom" custom-type="edited-by" id="fn0001">
<p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1712968/overview">Pengpeng Ye</ext-link>, Chinese Center for Disease Control and Prevention, China</p>
</fn>
<fn fn-type="custom" custom-type="reviewed-by" id="fn0002">
<p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1454527/overview">Jinhong Zhao</ext-link>, Chinese Academy of Medical Sciences and Peking Union Medical College, China</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3289024/overview">Tomoki Kawahara</ext-link>, Tokyo Kagaku Daigaku - Yushima Campus, Japan</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3304576/overview">Zhiming Lu</ext-link>, Capital Medical University, China</p>
</fn>
</fn-group>
</back>
</article>