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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title-group>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2296-2565</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2026.1657467</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Interpretable machine learning for identifying adolescent obesity risk and identifying key determinants</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Huang</surname>
<given-names>Liepeng</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3068910"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="resources" vocab-term-identifier="https://credit.niso.org/contributor-roles/resources/">Resources</role>
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<contrib contrib-type="author" corresp="yes">
<name>
<surname>Chen</surname>
<given-names>Jie</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3118713"/>
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<aff id="aff1"><label>1</label><institution>Faculty of Education, Shaanxi Normal University</institution>, <city>Xi&#x2019;an</city>, <state>Shaanxi</state>, <country country="cn">China</country></aff>
<aff id="aff2"><label>2</label><institution>Shandong Transport Vocational College</institution>, <city>Weifang</city>, <state>Shandong</state>, <country country="cn">China</country></aff>
<author-notes>
<corresp id="c001"><label>&#x002A;</label>Correspondence: Jie Chen, <email xlink:href="mailto:drchen2024@163.com">drchen2024@163.com</email></corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-02-25">
<day>25</day>
<month>02</month>
<year>2026</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2026</year>
</pub-date>
<volume>14</volume>
<elocation-id>1657467</elocation-id>
<history>
<date date-type="received">
<day>01</day>
<month>07</month>
<year>2025</year>
</date>
<date date-type="rev-recd">
<day>24</day>
<month>01</month>
<year>2026</year>
</date>
<date date-type="accepted">
<day>13</day>
<month>02</month>
<year>2026</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2026 Huang and Chen.</copyright-statement>
<copyright-year>2026</copyright-year>
<copyright-holder>Huang and Chen</copyright-holder>
<license>
<ali:license_ref start_date="2026-02-25">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Purpose</title>
<p>This study utilizes interpretable machine learning to identify and prioritize key associated factors for adolescent obesity across individual, family, and school domains, as well as to establish specific risk thresholds that can inform targeted interventions.</p>
</sec>
<sec>
<title>Methods</title>
<p>Data were obtained from the China Education Panel Survey (CEPS), which included 7,397 adolescents. Six ML models (SVM, XGBoost, LightGBM, LR, RF, MLP) were developed and evaluated. The best-performing model was interpreted using SHAP analysis to assess feature contributions.</p>
</sec>
<sec>
<title>Results</title>
<p>The LightGBM model demonstrated the highest accuracy (0.8788). This study primarily focused on the accurate classification of adolescent obesity status within a clinical decision-making context. Consequently, accuracy was prioritized as the key metric for directly assessing the model&#x2019;s overall classification performance. Key predictors of this model sedentary time, school ranking, academic workload, birth weight, body image, family economic status, school location, household registration, and physical activity. Among these, sedentary behavior emerged as the most significant predictor. Specific risk thresholds were identified, including sedentary time exceeding 5 h on weekends and birth weight greater than 4.0&#x202F;kg.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>This study underscores the utility of interpretable ML in identifying key predictors associated with adolescent obesity. The findings suggest that interventions might prioritize reducing sedentary behavior, the moderation of academic workload, and the enhancement of body image perception. Additionally, family and school environments play crucial roles in the prevention of obesity.</p>
</sec>
</abstract>
<kwd-group>
<kwd>adolescents</kwd>
<kwd>interpretable machine learning</kwd>
<kwd>obesity</kwd>
<kwd>relative importance</kwd>
<kwd>sedentary time</kwd>
</kwd-group>
<funding-group>
<funding-statement>The author(s) declared that financial support was not received for this work and/or its publication.</funding-statement>
</funding-group>
<counts>
<fig-count count="4"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="86"/>
<page-count count="11"/>
<word-count count="8690"/>
</counts>
<custom-meta-group>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Children and Health</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec1">
<label>1</label>
<title>Introduction</title>
<p>In recent years, rapid economic development and significant improvements in living standards have rendered adolescent obesity a critical global public health challenge (<xref ref-type="bibr" rid="ref1">1</xref>, <xref ref-type="bibr" rid="ref2">2</xref>). The global prevalence of adolescent obesity has doubled since 1990, becoming a critical public health challenge (<xref ref-type="bibr" rid="ref3">3</xref>, <xref ref-type="bibr" rid="ref4">4</xref>). In China, the Report on Nutrition and Chronic Disease Status of Chinese Residents (<xref ref-type="bibr" rid="ref5">5</xref>) indicates that the rates of overweight and obesity among children and adolescents aged 6 to 17 were 11.1 and 7.9%, respectively, in 2018, reflecting increases of 2.3 and 3.3% since 2012. Research evidence demonstrates that adolescent obesity is a significant risk factor for chronic diseases such as diabetes, hypertension, and hyperlipidemia (<xref ref-type="bibr" rid="ref6 ref7 ref8 ref9">6&#x2013;9</xref>), Furthermore, obesity during adolescence may persist into adulthood and later life (<xref ref-type="bibr" rid="ref10">10</xref>), adversely affecting mental health and overall quality of life (<xref ref-type="bibr" rid="ref11">11</xref>).</p>
<p>The early identification of high-risk groups and the implementation of targeted interventions can effectively prevent the onset and progression of adolescent obesity (<xref ref-type="bibr" rid="ref12">12</xref>). However, the use of a logistic regression model for identifying obesity has limitations, primarily due to the limited number 6+.</p>
<p>6r of predictor variables and their inadequate predictive power, which hinders the ability to capture non-linear relationships among these variables (<xref ref-type="bibr" rid="ref13">13</xref>, <xref ref-type="bibr" rid="ref14">14</xref>). To overcome this limitation, interpretable machine learning offers new avenues for analysis (<xref ref-type="bibr" rid="ref15">15</xref>). Machine learning models are capable of capturing complex, non-linear relationships across a wide range of variables from various domains. Additionally, post-hoc interpretation tools, such as SHAP (Shapley Additive Explanations), can clarify model predictions and highlight actionable insights.</p>
<p>Therefore, this study identifies predictors of adolescent obesity by developing six machine learning models: Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), Logistic Regression (LR), Random Forest (RF), and Multilayer Perceptron (MLP). Utilizing data from the China Education Panel Survey (CEPS) database, the study employs SHAP (Shapley Additive exPlanations) to interpret the prediction results of the best-performing models. This approach seeks to identify specific thresholds and the direction of associations among factors related to adolescent obesity, thereby examining the interrelationships among individual, family, and school domains associated with this condition. Ultimately, the findings are intended to provide actionable guidance for personalized health interventions. Existing machine learning studies on predicting adolescent obesity are limited in two significant ways. First, they typically concentrate on a single domain, neglecting to incorporate the synergistic effects of individual, family, and school factors. Second, even when interpretability tools are utilized, there is a persistent absence of actionable classification thresholds that can directly inform clinical or public health interventions across diverse populations. This study aims to address these gaps by developing a unified multi-domain model and identifying specific risk thresholds.</p>
</sec>
<sec id="sec2">
<label>2</label>
<title>Data and methods</title>
<sec id="sec3">
<label>2.1</label>
<title>Data</title>
<sec id="sec4">
<label>2.1.1</label>
<title>Data sources</title>
<p>The data utilized in this study originate from the China Education Panel Survey (CEPS), a longitudinal tracking survey developed and conducted by the China Survey and Data Centre at Renmin University of China (NSRC).<xref ref-type="fn" rid="fn0001"><sup>1</sup></xref> This survey encompasses a diverse range of participants, including students, parents, teachers, and school leaders, and is among the first nationally representative longitudinal studies of secondary school students in China, emphasizing family, school, and community-level factors. All CEPS data received approval from the Institutional Review Board of the People&#x2019;s University of China for research ethics concerning data collection within the CEPS dataset, and informed consent was obtained from all participants. Additionally, an ethical review for this study was conducted by Shandong Transport Vocational College.</p>
</sec>
<sec id="sec5">
<label>2.1.2</label>
<title>Data collection</title>
<sec id="sec6">
<label>2.1.2.1</label>
<title>Obesity</title>
<p>The study focuses on the weight status of adolescents, utilizing the Body Mass Index (BMI) as the primary screening tool to monitor the effectiveness of anti-obesity campaigns (<xref ref-type="bibr" rid="ref16">16</xref>). BMI is also recommended for clinical assessment of overweight and obesity in children and adolescents (<xref ref-type="bibr" rid="ref17">17</xref>), calculated using the formula: body weight (kg)/height (m)<sup>2</sup>. According to China&#x2019;s National Physical Fitness Standards for Students, a BMI of &#x2265; 25.3 indicates obesity in boys in the second year of junior high school, while a BMI of &#x2265; 24.9 indicates obesity in girls. Adolescents&#x2019; physical status is categorized into two groups: normal and obese. This study investigates the determinants associated with elevated BMI within an adolescent cohort. Anthropometric measurements, including height and weight, were obtained through self-report.</p>
</sec>
<sec id="sec7">
<label>2.1.2.2</label>
<title>Socio-demographic and behavioural characteristics</title>
<p>This study utilize data from the China Education Panel Survey (CEPS). Predictor variables were initially identified through a comprehensive literature review, with final selections made across individual, family, and school dimensions. Drawing from commonly used predictors in contemporary machine learning research on adolescent obesity, the following variables were included:</p>
<p>Individual-level variables:</p>
<p>Gender: Assessed by the question &#x201C;What is your gender?&#x201D;, coded as 0&#x202F;=&#x202F;female, 1&#x202F;=&#x202F;male.</p>
<p>Birth weight: Assessed by &#x201C;What was your birth weight?&#x201D;, categorized into low (&#x003C;2,500&#x202F;g), normal (2,500&#x2013;4,000&#x202F;g), and high (&#x003E;4,000&#x202F;g).</p>
<p>Household registration: Assessed by &#x201C;What is your household registration type?&#x201D;, coded as 0&#x202F;=&#x202F;agricultural, 1&#x202F;=&#x202F;non-agricultural.</p>
<p>Body image: Assessed by &#x201C;How do you think you look?&#x201D;, rated on a 5-point scale from 1&#x202F;=&#x202F;very ugly to 5&#x202F;=&#x202F;very beautiful.</p>
<p>Dietary habits: Assessed by &#x201C;How often do you eat fried food, barbecue, snacks, or Western fast food?&#x201D;, responses ranged from 1&#x202F;=&#x202F;never to 5&#x202F;=&#x202F;always.</p>
<p>Sleep quality: Evaluated using nine sleep-related issues (insomnia, easy awakening, drowsiness, no fatigue after waking, snoring, teeth grinding, dreaming, sleepwalking). The total number of reported issues was summed to form a continuous variable ranging from 0 to 9.</p>
<p>Sedentary time: Total hours spent on &#x201C;watching TV&#x201D; and &#x201C;surfing the internet/gaming&#x201D; during weekends; summed into a continuous variable (range: 0&#x2013;12).</p>
<p>Academic workload: Time spent on academic activities during weekends; summed into a continuous variable (range: 3&#x2013;18) based on three ordinal questions.</p>
<p>Weekend physical activity: Coded as 0&#x202F;=&#x202F;no, 1&#x202F;=&#x202F;yes.</p>
<p>Sports tutoring: &#x201C;Do you attend sports tutoring classes?&#x201D;, coded as 0&#x202F;=&#x202F;no, 1&#x202F;=&#x202F;yes.</p>
<p>Active commuting: &#x201C;Do you use active commuting (walking or cycling)?&#x201D;, coded as 0&#x202F;=&#x202F;no, 1&#x202F;=&#x202F;yes.</p>
<p>Physical activity frequency: Number of physical activity sessions per week, ranging from 0 to 7.</p>
<p>Family-level variables:</p>
<p>Paternal and maternal education: &#x201C;What is your father&#x2019;s/mother&#x2019;s education level?&#x201D;, coded as: 1&#x202F;=&#x202F;no formal education, 2&#x202F;=&#x202F;primary school, 3&#x202F;=&#x202F;junior high school, 4&#x202F;=&#x202F;vocational high school/technical school/regular high school, 5&#x202F;=&#x202F;college, 6&#x202F;=&#x202F;bachelor&#x2019;s degree, 7&#x202F;=&#x202F;master&#x2019;s degree or above.</p>
<p>Family economic status: &#x201C;What is your family&#x2019;s current economic condition?&#x201D;, rated on a 5-point scale from 1&#x202F;=&#x202F;very difficult to 5&#x202F;=&#x202F;very affluent.</p>
<p>Family structure: &#x201C;Are you an only child?&#x201D;, coded as 0&#x202F;=&#x202F;no, 1&#x202F;=&#x202F;yes.</p>
<p>School-level variables:</p>
<p>School type: Categorized as 1&#x202F;=&#x202F;public school, 2&#x202F;=&#x202F;private school, 3&#x202F;=&#x202F;private school for migrant workers&#x2019; children.</p>
<p>School ranking: &#x201C;What is your school&#x2019;s current ranking in this district?&#x201D;, rated from 1&#x202F;=&#x202F;worst to 5&#x202F;=&#x202F;best.</p>
<p>School location: Coded as 1&#x202F;=&#x202F;rural, 2&#x202F;=&#x202F;township, 3&#x202F;=&#x202F;urban&#x2013;rural fringe, 4&#x202F;=&#x202F;suburban, 5&#x202F;=&#x202F;central urban.</p>
<p>Sports facilities: Based on three items: &#x201C;Does your school have a sports ground?&#x201D;, &#x201C;a gymnasium?&#x201D;, and &#x201C;a swimming pool?&#x201D;; each coded as 1&#x202F;=&#x202F;no, 2&#x202F;=&#x202F;yes, and summed into a continuous score (range: 3&#x2013;6).</p>
</sec>
</sec>
<sec id="sec8">
<label>2.1.3</label>
<title>Data pre-processing</title>
<p>This study employed a rigorous sample selection process for data processing and analysis. The initial pilot survey was conducted in 2012, followed by a nationwide survey during the 2013&#x2013;2014 academic year. This nationwide survey included 28 county-level units across the country, from which 438 classes in 112 schools were randomly selected, involving a total of 10,279 seventh-grade students. By the follow-up survey in 2014, 9,449 participants were successfully tracked. Initial data cleaning and processing of the follow-up data resulted in 8,711 valid cases after the removal of invalid records. Subsequently, a statistical analysis of missing values was conducted for all variables. In accordance with methodological literature and principles of data integrity (<xref ref-type="bibr" rid="ref18">18</xref>), the baseline 2013 data exhibited missing values across several variables, including demographic characteristics&#x2014;gender (<italic>n</italic>&#x202F;=&#x202F;218 missing), BMI (<italic>n</italic>&#x202F;=&#x202F;232 missing), and urban&#x2013;rural registration (<italic>n</italic>&#x202F;=&#x202F;288 missing); family information&#x2014;parental education (<italic>n</italic>&#x202F;=&#x202F;428 missing) and family structure (<italic>n</italic>&#x202F;=&#x202F;143 missing); and individual characteristics&#x2014;academic burden (<italic>n</italic>&#x202F;=&#x202F;197 missing), sleep quality (<italic>n</italic>&#x202F;=&#x202F;190 missing), sedentary time (<italic>n</italic>&#x202F;=&#x202F;60 missing), weekly physical activity frequency (<italic>n</italic>&#x202F;=&#x202F;234 missing), and active commuting (<italic>n</italic>&#x202F;=&#x202F;62 missing). Variables with missing rates below 5% were addressed using listwise deletion to preserve the structural integrity of the sample. For the key research variable &#x201C;birth weight,&#x201D; which exhibited a higher missing rate of 15.44%, a conditional imputation approach was implemented. The data were stratified by gender and household registration (agricultural vs. non-agricultural), with missing birth weight values replaced by the mode within each subgroup. This methodology maximized sample retention while maintaining group representativeness, thereby ensuring scientifically sound and reasonable data imputation (<xref ref-type="bibr" rid="ref19 ref20 ref21">19&#x2013;21</xref>). The final analytical sample consisted of 7,397 participants (see <xref ref-type="fig" rid="fig1">Figure 1</xref>).</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>Participant selection flowchart.</p>
</caption>
<graphic xlink:href="fpubh-14-1657467-g001.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Flowchart showing participant data flow from baseline data in 2013 with ten thousand two hundred seventy-nine entries down to final data in 2014 with seven thousand three hundred ninety-seven entries. Data losses at each stage are detailed by reasons such as missing demographic, family, and individual information.</alt-text>
</graphic>
</fig>
</sec>
</sec>
<sec id="sec9">
<label>2.2</label>
<title>Research methodology</title>
<sec id="sec10">
<label>2.2.1</label>
<title>Feature screening methods</title>
<p>The dataset comprised a total of 7,397 participants, of whom 6,356 were classified into the normal weight group and 1,041 into the obese group. To mitigate overfitting and evaluate the generalization capability of the predictive models, the sample was randomly partitioned into a training set (70%) and a test set (30%) (<xref ref-type="bibr" rid="ref22">22</xref>). All data preprocessing and model development were conducted exclusively on the training set. Subsequently, 18 predictor variables were subjected to feature selection using Recursive Feature Elimination (RFE) (see <xref ref-type="fig" rid="fig2">Figure 2</xref>). Based on the refined feature subset, six machine learning algorithms were employed to construct risk prediction models for adolescent obesity: Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), Logistic Regression (LR), Random Forest (RF), and Multilayer Perceptron (MLP). These algorithms have been extensively utilized in prior research concerning obesity prediction in pediatric and adolescent populations (<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref24">24</xref>).</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>Recursive feature screening based on random forests (top 18).</p>
</caption>
<graphic xlink:href="fpubh-14-1657467-g002.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Bar and line chart illustrating the top 18 feature importances for a model, with academic workload showing the highest importance. A red line overlays mean AUC values for each feature, with shaded error margins.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec11">
<label>2.2.2</label>
<title>Machine learning methods</title>
<p>Utilizing Python&#x2019;s sci-kit-learn library and the LightGBM library, six machine-learning models were developed based on 18 selected feature variables. The algorithms employed were: Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), Logistic Regression (LR), Random Forest (RF), and Multilayer Perceptron (MLP). The performance of these six machine learning models was compared across various characteristics. Logistic Regression (LR) provides a computationally efficient and interpretable baseline (<xref ref-type="bibr" rid="ref25">25</xref>); Support Vector Machine (SVM) excels in high-dimensional spaces and nonlinear classification; XGBoost delivers high-accuracy prediction on structured data (<xref ref-type="bibr" rid="ref26">26</xref>); Gradient Boosting Machine (LightGBM) can flexibly fit complex patterns (<xref ref-type="bibr" rid="ref27">27</xref>); RF is robust and facilitates feature significance analysis (<xref ref-type="bibr" rid="ref28">28</xref>), while Multi-Layer Perceptron (MLP) can approximate arbitrary complex functions (<xref ref-type="bibr" rid="ref29">29</xref>). The optimal hyperparameters for each model were determined through Grid Search, aiming to minimize overfitting and enhance predictive performance. The optimal parameter configurations for each model are as follows: LR (C: 1, penalty: l2, solver: lbfgs); RF (max_depth: 10, min_samples_split: 5, n_estimators: 200); SVM (C: 1, gamma: auto, kernel: rbf); XGBoost (learning_rate: 0.1, max_depth: 3, n_estimators: 100); LightGBM (boosting_type: dart, learning_rate: 0.1, n_estimators: 200, num_leaves: 31); MLP (hidden_layer_sizes: 100, learning_rate_init: 0.01, max_iter: 200). The optimal parameter configurations obtained through Grid Search effectively mitigate the risk of overfitting and significantly enhance the predictive performance of each machine learning model on the dataset.</p>
</sec>
<sec id="sec12">
<label>2.2.3</label>
<title>Model evaluation and metric selection</title>
<p>The primary clinical decision-making scenario of this study centered on the accurate classification of obesity status rather than on ranking risk probabilities. Consequently, accuracy was chosen as the core optimization metric to directly reflect the model&#x2019;s overall capacity for making correct classifications. While the area under the curve (AUC) is a robust metric for evaluating a model&#x2019;s discriminative ability, accuracy offers a more intuitive and actionable performance measure for our specific application goals (see <xref ref-type="fig" rid="fig3">Figure 3</xref>). For a comprehensive comparison and reference, precision, sensitivity, and AUC were also calculated and reported alongside accuracy (see <xref rid="SM1" ref-type="supplementary-material">Supplementary material 1</xref> for details).</p>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>Comparison of ROC curves between training and test sets.</p>
</caption>
<graphic xlink:href="fpubh-14-1657467-g003.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Two ROC curve charts compare the performance of six machine learning models&#x2014;Logistic Regression, Random Forest, MLP, SVM, XGBoost, and GBM&#x2014;on training (left) and test (right) data, displaying AUC scores in the legends for each model and dataset.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec13">
<label>2.2.4</label>
<title>SHAP interpretable analysis methods</title>
<p>Shapley&#x2019;s explanatory approach, grounded in game theory, offers a robust framework for ensuring consistency, local fidelity and addressing missingness in any machine learning model (<xref ref-type="bibr" rid="ref30">30</xref>). Central to this approach is the capacity to evaluate the contribution of all predictor variables to model outcomes by converting the predictions into marginal contribution values for each variable (<xref ref-type="bibr" rid="ref18">18</xref>, <xref ref-type="bibr" rid="ref30">30</xref>). This methodology facilitates both individualized interpretations and broader insights into adolescent obesity prediction models. Higher SHAP values signify a positive influence of a variable on the model output, while lower values indicate a negative influence (<xref ref-type="bibr" rid="ref19">19</xref>).</p>
</sec>
<sec id="sec14">
<label>2.2.5</label>
<title>Methods of statistical analysis</title>
<p>Continuous variables were analyzed and compared according to the results of the normality test (Shapiro&#x2013;Wilk method). Variables exhibiting a normal distribution were reported as mean &#x00B1; standard deviation, with group comparisons conducted using the independent samples <italic>t</italic>-test. In contrast, variables with a non-normal distribution were presented as median (interquartile range), and group comparisons were performed using the Mann&#x2013;Whitney <italic>U</italic> test. Categorical variables were expressed as frequencies (percentages), with group comparisons based on the appropriate statistical test: the Pearson chi-square test was applied when the minimum expected frequency exceeded 5, while Fisher&#x2019;s exact test was utilized when it was 5 or fewer. All statistical analyses were conducted using two-sided tests, with a significant level set at <italic>p</italic>&#x202F;&#x003C;&#x202F;0.05.</p>
</sec>
</sec>
</sec>
<sec sec-type="results" id="sec15">
<label>3</label>
<title>Results</title>
<sec id="sec16">
<label>3.1</label>
<title>Participant characteristics</title>
<p>The study included 7,397 participants, categorized by weight status into a normal weight group (<italic>n</italic>&#x202F;=&#x202F;6,356, 85.9%) and an obese group (<italic>n</italic>&#x202F;=&#x202F;1,041, 14.1%). The rate of adolescent obesity is largely consistent with findings from previous studies (<xref ref-type="bibr" rid="ref20">20</xref>, <xref ref-type="bibr" rid="ref21">21</xref>, <xref ref-type="bibr" rid="ref31">31</xref>, <xref ref-type="bibr" rid="ref32">32</xref>). Differences across 20 variables between the two groups were assessed using chi-square tests (<italic>&#x03C7;</italic><sup>2</sup>) (see <xref rid="SM1" ref-type="supplementary-material">Supplementary material 2</xref> for details).</p>
<p>Individual-level factors: Statistically significant differences (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.05) were observed between the groups in gender, birth weight, urban/rural domicile, body image, dietary habits, sedentary time, and frequency of physical activity. Specifically, the obese group contained a higher proportion of males, more urban residents, individuals with heavier birth weight, lower body image perception, less healthy dietary habits, longer sedentary time, and lower frequency of physical activity.</p>
<p>Family-level factors: Significant differences (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.05) were identified in family economic status and family structure. Adolescents from very wealthy families had an obesity rate of 7.20%, showing a &#x201C;U-shaped&#x201D; distribution across economic levels. Additionally, the obesity rate among only-child families was 55.04%.</p>
<p>School-level factors: Significant differences (<italic>p</italic>&#x202F;&#x003C;&#x202F;0.05) were found in school ranking and school location between the obese and normal weight groups. Furthermore, weekend sports participation, attendance in sports counseling, and sleep quality were significantly lower in the obese group.</p>
</sec>
<sec id="sec17">
<label>3.2</label>
<title>Predictive performance of machine learning models</title>
<p>Six machine learning models were used to predict the incidence of obesity in adolescents. The performance of these models is shown in <xref ref-type="table" rid="tab1">Table 1</xref> and illustrated mainly by ROC and Accuracy. A side-by-side comparison of SVM, XGBoost, LightGBM, LR, RF, and MLP in the training set and the test model reveals that the LightGBM model exhibits the best discriminative ability (accuracy&#x202F;=&#x202F;0.8788, AUC&#x202F;=&#x202F;0.7392), with a significant advantage over the other models (<xref ref-type="bibr" rid="ref33">33</xref>).</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Six machine learning prediction model scores.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Model</th>
<th align="left" valign="top">Dataset</th>
<th align="center" valign="top">Accuracy</th>
<th align="center" valign="top">AUC</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">SVM</td>
<td align="left" valign="middle">Train</td>
<td align="center" valign="middle">0.8856</td>
<td align="center" valign="middle">0.8911</td>
</tr>
<tr>
<td align="left" valign="middle">SVM</td>
<td align="left" valign="middle">Test</td>
<td align="center" valign="middle">0.8658</td>
<td align="center" valign="middle">0.6765</td>
</tr>
<tr>
<td align="left" valign="middle">XGBoost</td>
<td align="left" valign="middle">Train</td>
<td align="center" valign="middle">0.8864</td>
<td align="center" valign="middle">0.8108</td>
</tr>
<tr>
<td align="left" valign="middle">XGBoost</td>
<td align="left" valign="middle">Test</td>
<td align="center" valign="middle">0.8779</td>
<td align="center" valign="middle">0.7450</td>
</tr>
<tr>
<td align="left" valign="middle">LightGBM</td>
<td align="left" valign="middle">Train</td>
<td align="center" valign="middle">0.8997</td>
<td align="center" valign="middle">0.9062</td>
</tr>
<tr>
<td align="left" valign="middle">LightGBM</td>
<td align="left" valign="middle">Test</td>
<td align="center" valign="middle">0.8788</td>
<td align="center" valign="middle">0.7392</td>
</tr>
<tr>
<td align="left" valign="middle">LR</td>
<td align="left" valign="middle">Train</td>
<td align="center" valign="middle">0.8685</td>
<td align="center" valign="middle">0.7168</td>
</tr>
<tr>
<td align="left" valign="middle">LR</td>
<td align="left" valign="middle">Test</td>
<td align="center" valign="middle">0.8712</td>
<td align="center" valign="middle">0.7194</td>
</tr>
<tr>
<td align="left" valign="middle">R F</td>
<td align="left" valign="middle">Train</td>
<td align="center" valign="middle">0.8967</td>
<td align="center" valign="middle">0.8999</td>
</tr>
<tr>
<td align="left" valign="middle">R F</td>
<td align="left" valign="middle">Test</td>
<td align="center" valign="middle">0.8770</td>
<td align="center" valign="middle">0.739</td>
</tr>
<tr>
<td align="left" valign="middle">MLP</td>
<td align="left" valign="middle">Train</td>
<td align="center" valign="middle">0.8723</td>
<td align="center" valign="middle">0.7625</td>
</tr>
<tr>
<td align="left" valign="middle">MLP</td>
<td align="left" valign="middle">Test</td>
<td align="center" valign="middle">0.8725</td>
<td align="center" valign="middle">0.7143</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec18">
<label>3.3</label>
<title>Decision curve analysis</title>
<p>To assess the clinical utility of the predictive model in facilitating decision-making, we employed Decision Curve Analysis (DCA) for validation (<xref ref-type="bibr" rid="ref34">34</xref>). The results of the DCA for both the training and test sets are presented in <xref rid="SM1" ref-type="supplementary-material">Supplementary material 3</xref>. The DCA results for the test set demonstrated that the machine learning model possesses clinical utility. This study established a threshold probability range of 10&#x2013;60% as reasonable for clinical decision-making. This range is consistent with the conventions of decision curve analysis in the field of childhood obesity risk prediction (<xref ref-type="bibr" rid="ref35">35</xref>), indicating that utilizing our Gradient Boosting Machine (LightGBM) model to inform decisions would yield superior outcomes, exhibiting a higher net benefit compared to the strategies of &#x201C;intervene for all&#x201D; and &#x201C;intervene for none.&#x201D; The performance of each model in the training set exhibited a similar, albeit more optimistic, trend, which aligns with our expectations.</p>
</sec>
<sec id="sec19">
<label>3.4</label>
<title>Relative importance of combined factors on adolescent obesity</title>
<p>The Gradient Boosting Machine (LightGBM) demonstrated superior performance in explaining adolescent obesity. <xref ref-type="fig" rid="fig4">Figure 4A</xref> illustrates the ranking of variable importance within the model, specifically highlighting the 10 characteristics that exert the most significant influence on adolescent obesity. Among these, sedentary time is identified as the most critical risk factor. The X-axis indicates that Higher SHAP values indicate a stronger positive association with the model&#x2019;s prediction of obesity, corresponding to an increased predicted likelihood of obesity, while lower values suggest a reduced likelihood of obesity. A color gradient ranging from red to blue represents the magnitude of feature values, with red denoting high values and blue indicating low values. Furthermore, an increased feature value associated with school location preference (e.g., central city), high academic workload, high birth weight, low self-assessment of body image, favorable family economic conditions (middle class and above), non-agricultural domicile, low school ranking, and infrequent physical activity were also recognized as significant predictors of adolescent obesity (<xref ref-type="fig" rid="fig4">Figure 4B</xref>).</p>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption>
<p>Relative importance of combined factors on adolescent obesity. <bold>(A)</bold> Feature importance; <bold>(B)</bold> SHAP results; <bold>(C)</bold> Impact of features on model output, from top left to bottom right: Sedentary time, school ranking, academic workload, birth weight, body image, family economy, school location, household registration, and physical activity. The horizontal axis represents the actual value of a particular feature, while the vertical axis represents the corresponding SHAP value for that feature (i.e., the effect of the characteristic on the model output: positive values indicate a positive effect, while negative values indicate a negative effect), PA, physical activity.</p>
</caption>
<graphic xlink:href="fpubh-14-1657467-g004.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Bar chart (panel A) and summary dot plot (panel B) display the top ten SHAP feature importances and their impacts on obesity prediction, with features like gender, sedentary time, and school location most influential. Dot plot shows SHAP value distributions color-coded by feature value from low (blue) to high (red). Figure contains seven SHAP dependence plots displaying the relationship between SHAP values and various features: Sedentary Time, School Rank, Academic Workload, Birth Weight, Body Image, Family Economics, School Location, and Physical Activity Frequency, each with individual data points and trendlines.</alt-text>
</graphic>
</fig>
<p>Specifically, adolescents who engage in more than 5 h of sedentary activity per day on weekends, participate in fewer than 3.5 physical activity sessions per week, and possess an academic workload value of less than 3 or greater than 10 are at an elevated risk of obesity. Additionally, school rank is negatively correlated with the risk of obesity in adolescents, while those with birth weights exceeding the normal range (&#x003E;4.0&#x202F;kg) also face an increased risk. Furthermore, adolescents who have a low self-assessment of body image (&#x2264;3) are at heightened risk of obesity. In contrast, adolescents from families with medium to high economic status and those attending schools located above the township level are predicted to be at an increased risk of obesity.</p>
</sec>
</sec>
<sec sec-type="discussion" id="sec20">
<label>4</label>
<title>Discussion</title>
<p>In alignment with the complex and multifactorial nature of adolescent obesity, this study utilized an interpretable machine learning approach to assess the relative significance of individual, family, and school factors in identifying obesity among adolescents. Utilizing data from the China Education Panel Survey (CEPS) comprising 7,397 valid samples, we identified several predisposing factors across these three dimensions. Notably, sedentary time emerged as the strongest predictor, consistent with previous studies that underscore its central role in obesity prevention (<xref ref-type="bibr" rid="ref36 ref37 ref38">36&#x2013;38</xref>). This study is the first to integrate individual, family, and school factors within a unified model, offering a more comprehensive perspective on the combined influences affecting adolescent obesity.</p>
<p>At the family level, economic status is a significant determinant of obesity. Adolescents from medium- and high-income families exhibit a higher likelihood of obesity, consistent with existing literature (<xref ref-type="bibr" rid="ref39">39</xref>, <xref ref-type="bibr" rid="ref40">40</xref>). Improved economic conditions may be associated with over-nutrition (<xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref42">42</xref>), characterized by increased consumption of high-sugar beverages and fast food due to greater disposable income and allowances (<xref ref-type="bibr" rid="ref43">43</xref>). Additionally, these conditions may correlate with reduced physical activity facilitated by motorized transportation (<xref ref-type="bibr" rid="ref44">44</xref>, <xref ref-type="bibr" rid="ref45">45</xref>). Collectively, these potential pathways may explain the observed association with an elevated risk of obesity. Therefore, fostering healthy family environments and behavioral patterns is essential to avoid the &#x201C;convenience trap&#x201D; and promote active lifestyles and balanced diets.</p>
<p>Another notable finding is the elevated obesity rate among adolescents from only-child families (55.04%). This finding aligns with the results of Formisano (<xref ref-type="bibr" rid="ref46">46</xref>), Hunsberger (<xref ref-type="bibr" rid="ref47">47</xref>), and others. This phenomenon may be attributed to concentrated family resources leading to over-nutrition, heightened academic expectations resulting in reduced physical activity (<xref ref-type="bibr" rid="ref48">48</xref>), increased stress-related eating (<xref ref-type="bibr" rid="ref49">49</xref>), or differing parenting styles (<xref ref-type="bibr" rid="ref50">50</xref>). This underscores the necessity for targeted nutritional and lifestyle guidance within single-child family contexts.</p>
<p>School-related factors, such as proximity to urban centers and lower school rankings, are associated with higher an increased risk of obesity. Schools in central urban areas often lack safe infrastructure for walking and cycling (<xref ref-type="bibr" rid="ref51">51</xref>), and they are typically surrounded by greater access to high-calorie foods (<xref ref-type="bibr" rid="ref52">52</xref>, <xref ref-type="bibr" rid="ref53">53</xref>). Additionally, Lower-ranked schools may provide inadequate physical education resources, subpar curriculum quality, and insufficient nutritional offerings (<xref ref-type="bibr" rid="ref54">54</xref>, <xref ref-type="bibr" rid="ref55">55</xref>). In contrast, higher-ranked schools tend to prioritize holistic student development, including physical activity and healthy eating (<xref ref-type="bibr" rid="ref56">56</xref>, <xref ref-type="bibr" rid="ref57">57</xref>). These findings highlight the necessity of enhancing the physical environments of schools, strengthening physical and health education programs, and ensuring nutritional balance in school meals.</p>
<p>At the individual level, gender, sedentary time, birth weight, body image, academic workload, and frequency of physical activity emerged as significant predictors. Both intrinsic factors (e.g., gender, birth weight, household registration) and extrinsic factors (e.g., sedentary behavior, body image, academic load, and physical activity) exerted considerable influence.</p>
<p>Birth weight: Normal newborns typically have a birth weight ranging from 2,500 to 4,000 grams (<xref ref-type="bibr" rid="ref58">58</xref>). This study indicates that exceeding the normal birth weight is a significant predictor of obesity in adolescents. These findings are consistent with two systematic reviews that examined the relationship between birth weight and obesity in children and adolescents, underscoring the strong association between high birth weight and obesity, as well as the protective effect of low birth weight (<xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref60">60</xref>). Children born with high birth weight often have a greater number of adipocytes and an increased capacity for fat storage, rendering them susceptible to fat accumulation when excess energy is available (<xref ref-type="bibr" rid="ref61">61</xref>). Furthermore, this condition is associated with maternal weight and dietary habits both before and after pregnancy (<xref ref-type="bibr" rid="ref62">62</xref>, <xref ref-type="bibr" rid="ref63">63</xref>), as well as with overfeeding behaviors in the home (<xref ref-type="bibr" rid="ref64">64</xref>). Therefore, the long-term importance of maternal health management and evidence-based infant and young child feeding practices cannot be overstated.</p>
<p>Body image: This study demonstrated an association between low self-assessment of body image and an increased risk of obesity, consistent with findings from an Australian study (<xref ref-type="bibr" rid="ref65">65</xref>). Evidence indicates that a higher body mass index (BMI) is consistently linked to poor body image and body dissatisfaction (<xref ref-type="bibr" rid="ref66">66</xref>). Students who possess high body image satisfaction or acceptance exhibit greater self-efficacy and self-esteem (<xref ref-type="bibr" rid="ref67">67</xref>) and are more likely to engage in and maintain healthy lifestyle behaviors (<xref ref-type="bibr" rid="ref68">68</xref>), which could be a pathway linking body image to obesity risk. While simultaneously mitigating negative emotions such as anxiety, depression, and stress (<xref ref-type="bibr" rid="ref69">69</xref>), which can directly or indirectly promote unhealthy behaviors (<xref ref-type="bibr" rid="ref70">70</xref>) that increase energy intake and the risk of obesity. Additionally, the aesthetic notion that &#x201C;thinness is beautiful&#x201D; (<xref ref-type="bibr" rid="ref71">71</xref>, <xref ref-type="bibr" rid="ref72">72</xref>) may motivate adolescents to manage their body weight, thereby reducing their risk of obesity. Consequently, obesity prevention efforts targeting adolescents should also emphasize mental health and the cultivation of accurate and positive body awareness, as well as intrinsic health motivation.</p>
<p>This study demonstrates an association between low self-assessment of body image and an increased risk of obesity, consistent with findings from an Australian study (<xref ref-type="bibr" rid="ref65">65</xref>). Evidence indicates that a higher body mass index (BMI) is consistently linked to poor body image and body dissatisfaction (<xref ref-type="bibr" rid="ref66">66</xref>). Students who exhibit high body image satisfaction or acceptance demonstrate greater self-efficacy and self-esteem (<xref ref-type="bibr" rid="ref67">67</xref>) and are more likely to engage in and maintain healthy lifestyle behaviors (<xref ref-type="bibr" rid="ref68">68</xref>). This relationship may serve as a pathway linking body image to obesity risk while simultaneously mitigating negative emotions such as anxiety, depression, and stress (<xref ref-type="bibr" rid="ref69">69</xref>), which can directly or indirectly promote unhealthy behaviors (<xref ref-type="bibr" rid="ref70">70</xref>) that increase energy intake and the risk of obesity. Furthermore, the aesthetic notion that &#x201C;thinness is beautiful&#x201D; (<xref ref-type="bibr" rid="ref71">71</xref>, <xref ref-type="bibr" rid="ref72">72</xref>) may motivate adolescents to manage their body weight, thereby reducing their risk of obesity. Consequently, obesity prevention efforts targeting adolescents should also emphasize mental health and the cultivation of accurate and positive body awareness, as well as intrinsic health motivation.</p>
<p>Sedentary time refers to prolonged periods of sedentary behavior, such as watching television, playing video games, or using a computer (<xref ref-type="bibr" rid="ref73">73</xref>). This study indicates that longer sedentary time is associated with a higher risk of obesity in adolescents, a finding that aligns with existing academic research (<xref ref-type="bibr" rid="ref74">74</xref>, <xref ref-type="bibr" rid="ref75">75</xref>). Sedentary behavior is generally associated with decreased levels of physical activity and daily energy expenditure, which in turn leads to a diminished rate of fat oxidation in the muscles (<xref ref-type="bibr" rid="ref76">76</xref>). When energy expenditure is lower than energy intake, the excess energy is converted into fat for storage (<xref ref-type="bibr" rid="ref77">77</xref>). Furthermore, sedentary behavior represents an allocation of time resources in adolescents&#x2019; daily lives, leading to decreased physical activity and disrupted rest due to the crowding out of active pursuits. Consequently, this contributes to the development of obesity.</p>
<p>Academic workload: Our analysis revealed a U-shaped association between academic workload and obesity risk, indicating that values below 3 or above 10 significantly elevate this risk. Existing studies have demonstrated that a high academic workload is associated with obesity in adolescents (<xref ref-type="bibr" rid="ref78">78</xref>); this is primarily due to excessive academic pressure, which extends study hours, reduces physical activity, and disrupts sleep quality (<xref ref-type="bibr" rid="ref79">79</xref>). Concurrently, such pressure may heighten adolescents&#x2019; cravings for high-sugar and high-fat foods (<xref ref-type="bibr" rid="ref80">80</xref>), contributing to fat accumulation and an increased likelihood of obesity. Additionally, our study found that a low academic workload also correlates with an increased risk of obesity. However, there is a relative scarcity of research exploring the positive association between low academic workload and obesity. This may be attributed to poor time management, which can lead to increased sedentary behavior and irregularities in lifestyle that adversely affect diet and physical activity. Further research is necessary to validate the underlying mechanisms and prevalence of these associations.</p>
<p>Physical Activity Frequency: This study demonstrates that the frequency of physical activity is negatively associated with obesity in adolescents. Previous research indicates that participation in physical activity is the most effective strategy for preventing obesity in this population (<xref ref-type="bibr" rid="ref81">81</xref>). Physical activity induces beneficial changes in various health metrics, including fat percentage, waist circumference, systolic blood pressure, insulin levels, LDL cholesterol, and total cholesterol (<xref ref-type="bibr" rid="ref82">82</xref>). Additionally, it enhances basal energy metabolism, improves body composition, and promotes healthy sleep and psychological well-being. The multifactorial effects of these changes can significantly mitigate the onset and progression of obesity among adolescents.</p>
<p>It is crucial to further delineate the modifiable and non-modifiable associated factors identified in this study. Factors such as birth weight and school location are not easily altered through individual behavior; however, their strong association with the risk of adolescent obesity renders them valuable screening indicators for the early identification of high-risk individuals. Consequently, adolescents with a high birth weight (greater than 4.0&#x202F;kg) or those attending schools in central urban areas should be prioritized for enhanced screening and targeted lifestyle interventions that focus on modifiable factors, such as sedentary behavior and physical activity levels. This approach aligns with precision public health strategies, facilitating a more efficient allocation of resources to subgroups that are most in need of intervention.</p>
<p>This study developed six machine learning models&#x2014;Support Vector Machine (SVM), XGBoost, Gradient Boosting Machine (LightGBM), Logistic Regression (LR), Random Forest (RF), and Multi-Layer Perceptron (MLP)&#x2014;to predict adolescent obesity. The area under the curve (AUC) value of 0.7392 reported in this study is lower than the range of 0.84 to 0.91 found in Li et al.&#x2019;s study on adults (<xref ref-type="bibr" rid="ref85">85</xref>). This discrepancy may arise from several factors. First, the study populations differ, with adolescents exhibiting more complex and multifaceted influencing factors for obesity compared to adults. Second, this study included a broader range of social environmental and school-level characteristics, which may demonstrate stronger non-linear relationships with the outcome and introduce additional noise (<xref ref-type="bibr" rid="ref86">86</xref>). Finally, the use of self-reported height and weight to calculate body mass index (BMI) may have introduced measurement error. Although the AUC is moderate, the high classification accuracy of 0.8788 is of greater practical significance for effectively classifying individuals within the population, particularly in the context of large-scale screening. In conclusion, we contend that an AUC of 0.7392 is acceptable within the framework of this study.</p>
<p>Finally, this study identified actionable thresholds: &#x003E;5&#x202F;h of sedentary time on weekends, &#x003C;3.5 physical activity sessions per week, academic workload &#x003C;3 or &#x003E;10, birth weight &#x003E;4.0&#x202F;kg, body image score &#x2264;3, and medium/high family economic status were associated with increased obesity risk. These align with the Technical Guidelines for Comprehensive Public Health Prevention and Control of Overweight and Obesity in Primary and Secondary School Students (2024), which recommend 3&#x2013;4 moderate-to-vigorous physical activity sessions per week, limited sedentary and screen time, and emphasize the roles of family and school in obesity prevention.</p>
<p>Several limitations must be acknowledged. Identifying factors associated with adolescent obesity across individual, family, and school domains is complex due to the multitude of potential influences; consequently, certain relevant factors may not have been included in the current study&#x2019;s model. This study employed a cross-sectional design, which, while revealing associations between variables, cannot infer causality. Furthermore, key indicators such as height and weight were based on self-reports. Although several studies have indicated moderate to high correlations between self-reported and measured anthropometric data in adolescent populations (<xref ref-type="bibr" rid="ref83">83</xref>, <xref ref-type="bibr" rid="ref84">84</xref>), measurement bias is inevitable and may lead to the underestimation or overestimation of obesity prevalence. Future research should adopt longitudinal designs and incorporate objective measurements to validate and extend these findings. Additionally, including objective data, such as biochemical indicators, would enhance the richness of the sample. Regarding the feature selection strategy, although Recursive Feature Elimination with cross-validation was effectively employed to prevent overfitting and information leakage, we did not systematically compare it with alternative strategies (e.g., Lasso regularization path, filter methods based on mutual information, or embedded methods). Consequently, the selected feature subset represents one of many potentially effective combinations and may not be globally optimal. Future studies could compare multiple feature selection strategies to assess the stability of both the final model performance and the selected features. Finally, although SHAP provides valuable insights, it remains a post-hoc interpretation tool and does not fully address the &#x201C;black-box&#x201D; nature of complex models like Gradient Boosting Machines (LightGBM). Therefore, it is essential to explore the use of more sophisticated and accurate prediction models to improve predictive performance and continuously enhance the interpretability of the results.</p>
</sec>
<sec sec-type="conclusions" id="sec21">
<label>5</label>
<title>Conclusion</title>
<p>The data for this study were obtained from the China Education Tracking Survey (CEPS) database, which included 7,397 adolescents. Six machine learning models were developed to predict the risk of adolescent obesity using the CEPS database, with the Gradient Boosting Machine (LightGBM) model demonstrating superior overall predictive accuracy and stability compared to the other five models. The study revealed demographic differences in adolescent obesity and underscored the relative importance of factors such as sedentary time, school zone, birth weight, and body image. This research proposes three evidence-based intervention targets: (1) limiting recreational screen time to less than 2&#x202F;h per day, (2) ensuring a moderate academic workload (3&#x2013;10 on a standardized scale), and (3) enhancing body image literacy. These targets aim to inform the development of interventions for preventing and managing adolescent obesity. The specific risk thresholds identified for certain factors in this study may guide future measures for adolescent obesity prevention. Furthermore, additional individual, school, and family factors should be incorporated into future research to assess the generalizability of these findings.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="sec22">
<title>Data availability statement</title>
<p>The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article/<xref rid="SM1" ref-type="supplementary-material">Supplementary material</xref>.</p>
</sec>
<sec sec-type="ethics-statement" id="sec23">
<title>Ethics statement</title>
<p>The studies involving humans were approved by Shandong Transport Vocational College. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation was not required from the participants or the participants&#x2019; legal guardians/next of kin in accordance with the national legislation and institutional requirements.</p>
</sec>
<sec sec-type="author-contributions" id="sec24">
<title>Author contributions</title>
<p>LH: Resources, Conceptualization, Project administration, Writing &#x2013; original draft, Validation, Funding acquisition, Formal analysis, Visualization, Methodology, Supervision, Data curation, Investigation, Software, Writing &#x2013; review &#x0026; editing. JC: Project administration, Formal analysis, Writing &#x2013; review &#x0026; editing, Writing &#x2013; original draft, Conceptualization, Visualization, Investigation, Funding acquisition.</p>
</sec>
<sec sec-type="COI-statement" id="sec25">
<title>Conflict of interest</title>
<p>The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="sec26">
<title>Generative AI statement</title>
<p>The author(s) declared that Generative AI was not used in the creation of this manuscript.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p>
</sec>
<sec sec-type="disclaimer" id="sec27">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec sec-type="supplementary-material" id="sec28">
<title>Supplementary material</title>
<p>The Supplementary material for this article can be found online at: <ext-link xlink:href="https://www.frontiersin.org/articles/10.3389/fpubh.2026.1657467/full#supplementary-material" ext-link-type="uri">https://www.frontiersin.org/articles/10.3389/fpubh.2026.1657467/full#supplementary-material</ext-link></p>
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<supplementary-material xlink:href="Supplementary_file_2.doc" id="SM2" mimetype="application/vnd.ms-word" xmlns:xlink="http://www.w3.org/1999/xlink"/>
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<ref-list>
<title>References</title>
<ref id="ref1"><label>1.</label> <mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>James</surname><given-names>WPT</given-names></name></person-group>. <article-title>Obesity: a global public health challenge</article-title>. <source>Clin Chem</source>. (<year>2018</year>) <volume>64</volume>:<fpage>24</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1373/clinchem.2017.273052</pub-id>, <pub-id pub-id-type="pmid">29295834</pub-id></mixed-citation></ref>
<ref id="ref2"><label>2.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Edward</surname><given-names>S</given-names></name> <name><surname>Gopalakrishnan</surname><given-names>S</given-names></name></person-group>. <article-title>Adolescent obesity&#x2013;emerging public health problem of 21st century</article-title>. <source>Natl J Community Med</source>. (<year>2022</year>) <volume>13</volume>:<fpage>43</fpage>&#x2013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.5455/njcm.20211020091723</pub-id></mixed-citation></ref>
<ref id="ref3"><label>3.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Okunogbe</surname><given-names>A</given-names></name> <name><surname>Nugent</surname><given-names>R</given-names></name> <name><surname>Spencer</surname><given-names>G</given-names></name> <name><surname>Powis</surname><given-names>J</given-names></name> <name><surname>Ralston</surname><given-names>J</given-names></name> <name><surname>Wilding</surname><given-names>J</given-names></name></person-group>. <article-title>Economic impacts of overweight and obesity: current and future estimates for 161 countries</article-title>. <source>BMJ Glob Health</source>. (<year>2022</year>) <volume>7</volume>:<fpage>e009773</fpage>. doi: <pub-id pub-id-type="doi">10.1136/bmjgh-2022-009773</pub-id>, <pub-id pub-id-type="pmid">36130777</pub-id></mixed-citation></ref>
<ref id="ref4"><label>4.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ge</surname><given-names>C</given-names></name> <name><surname>Xiong</surname><given-names>J</given-names></name> <name><surname>Zhu</surname><given-names>R</given-names></name> <name><surname>Hong</surname><given-names>Z</given-names></name> <name><surname>He</surname><given-names>Y</given-names></name></person-group>. <article-title>The global burden of high BMI among adolescents between 1990 and 2021</article-title>. <source>Commun Med</source>. (<year>2025</year>) <volume>5</volume>:<fpage>125</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s43856-025-00838-2</pub-id>, <pub-id pub-id-type="pmid">40247108</pub-id></mixed-citation></ref>
<ref id="ref5"><label>5.</label><mixed-citation publication-type="book"><collab id="coll1">The National Health and Family Planning Commission</collab>. <source>Report on nutrition and chronic disease status of Chinese residents</source>. <publisher-loc>Beijing</publisher-loc>: <publisher-name>People&#x2019;s Medical Publishing House</publisher-name> (<year>2020</year>).</mixed-citation></ref>
<ref id="ref6"><label>6.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lobstein</surname><given-names>T</given-names></name> <name><surname>Baur</surname><given-names>L</given-names></name> <name><surname>Uauy</surname><given-names>R</given-names></name></person-group>. <article-title>Obesity in children and young people: a crisis in public health</article-title>. <source>Obes Rev</source>. (<year>2004</year>) <volume>5 Suppl 1</volume>:<fpage>4</fpage>&#x2013;<lpage>104</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1467-789X.2004.00133.x</pub-id>, <pub-id pub-id-type="pmid">15096099</pub-id></mixed-citation></ref>
<ref id="ref7"><label>7.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>YC</given-names></name> <name><surname>Mcpherson</surname><given-names>K</given-names></name> <name><surname>Marsh</surname><given-names>T</given-names></name> <name><surname>Gortmaker</surname><given-names>SL</given-names></name> <name><surname>Brown</surname><given-names>M</given-names></name></person-group>. <article-title>Health and economic burden of the projected obesity trends in the USA and the UK</article-title>. <source>Lancet</source>. (<year>2011</year>) <volume>378</volume>:<fpage>815</fpage>&#x2013;<lpage>25</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s0140-6736(11)60814-3</pub-id>, <pub-id pub-id-type="pmid">21872750</pub-id></mixed-citation></ref>
<ref id="ref8"><label>8.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Puhl</surname><given-names>RM</given-names></name> <name><surname>Heuer</surname><given-names>CA</given-names></name></person-group>. <article-title>The stigma of obesity: a review and update</article-title>. <source>Obesity</source>. (<year>2009</year>) <volume>17</volume>:<fpage>941</fpage>&#x2013;<lpage>64</lpage>. doi: <pub-id pub-id-type="doi">10.1038/oby.2008.636</pub-id>, <pub-id pub-id-type="pmid">19165161</pub-id></mixed-citation></ref>
<ref id="ref9"><label>9.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stunkard</surname><given-names>AJ</given-names></name> <name><surname>Faith</surname><given-names>MS</given-names></name> <name><surname>Allison</surname><given-names>KC</given-names></name></person-group>. <article-title>Depression and obesity</article-title>. <source>Biol Psychiatry</source>. (<year>2003</year>) <volume>54</volume>:<fpage>330</fpage>&#x2013;<lpage>7</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s0006-3223(03)00608-5</pub-id>, <pub-id pub-id-type="pmid">12893108</pub-id></mixed-citation></ref>
<ref id="ref10"><label>10.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Bixby</surname><given-names>H</given-names></name> <name><surname>Mishra</surname><given-names>A</given-names></name> <name><surname>Martinez</surname><given-names>A. R.</given-names></name></person-group> (<year>2025</year>). <chapter-title>Worldwide levels and trends in childhood obesity</chapter-title>. In: <source>Childhood obesity</source>. <publisher-name>Elsevier</publisher-name>: <publisher-name>Academic Press</publisher-name>. <fpage>21</fpage>&#x2013;<lpage>40</lpage>.</mixed-citation></ref>
<ref id="ref11"><label>11.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Swallen</surname><given-names>KC</given-names></name> <name><surname>Reither</surname><given-names>EN</given-names></name> <name><surname>Haas</surname><given-names>SA</given-names></name> <name><surname>Meier</surname><given-names>AM</given-names></name></person-group>. <article-title>Overweight, obesity, and health-related quality of life among adolescents: the National Longitudinal Study of adolescent health</article-title>. <source>Pediatrics</source>. (<year>2005</year>) <volume>115</volume>:<fpage>340</fpage>&#x2013;<lpage>7</lpage>. doi: <pub-id pub-id-type="doi">10.1542/peds.2004-0678</pub-id>, <pub-id pub-id-type="pmid">15687442</pub-id></mixed-citation></ref>
<ref id="ref12"><label>12.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barlow</surname><given-names>SE</given-names></name> <name><surname>Committee</surname><given-names>E</given-names></name></person-group>. <article-title>Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report</article-title>. <source>Pediatrics</source>. (<year>2007</year>) <volume>120</volume>:<fpage>S164</fpage>&#x2013;<lpage>92</lpage>. doi: <pub-id pub-id-type="doi">10.1542/peds.2007-2329C</pub-id></mixed-citation></ref>
<ref id="ref13"><label>13.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marcos-Pasero</surname><given-names>H</given-names></name> <name><surname>Colmenarejo</surname><given-names>G</given-names></name> <name><surname>Aguilar-Aguilar</surname><given-names>E</given-names></name> <name><surname>Ram&#x00ED;rez de Molina</surname><given-names>A</given-names></name> <name><surname>Reglero</surname><given-names>G</given-names></name> <name><surname>Loria-Kohen</surname><given-names>V</given-names></name></person-group>. <article-title>Ranking of a wide multidomain set of predictor variables of children obesity by machine learning variable importance techniques</article-title>. <source>Sci Rep</source>. (<year>2021</year>) <volume>11</volume>:<fpage>1910</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41598-021-81205-8</pub-id>, <pub-id pub-id-type="pmid">33479310</pub-id></mixed-citation></ref>
<ref id="ref14"><label>14.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhang</surname><given-names>S</given-names></name> <name><surname>Tjortjis</surname><given-names>C</given-names></name> <name><surname>Zeng</surname><given-names>X</given-names></name> <name><surname>Qiao</surname><given-names>H</given-names></name> <name><surname>Buchan</surname><given-names>I</given-names></name> <name><surname>Keane</surname><given-names>J</given-names></name></person-group>. <article-title>Comparing data mining methods with logistic regression in childhood obesity prediction</article-title>. <source>Inf Syst Front</source>. (<year>2009</year>) <volume>11</volume>:<fpage>449</fpage>&#x2013;<lpage>60</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s10796-009-9157-0</pub-id></mixed-citation></ref>
<ref id="ref15"><label>15.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Colmenarejo</surname><given-names>G</given-names></name></person-group>. <article-title>Machine learning models to predict childhood and adolescent obesity: a review</article-title>. <source>Nutrients</source>. (<year>2020</year>) <volume>12</volume>:<fpage>2466</fpage>. doi: <pub-id pub-id-type="doi">10.3390/nu12082466</pub-id>, <pub-id pub-id-type="pmid">32824342</pub-id></mixed-citation></ref>
<ref id="ref16"><label>16.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Khanna</surname><given-names>D</given-names></name> <name><surname>Peltzer</surname><given-names>C</given-names></name> <name><surname>Kahar</surname><given-names>P</given-names></name> <name><surname>Parmar</surname><given-names>MS</given-names></name></person-group>. <article-title>Body mass index (BMI): a screening tool analysis</article-title>. <source>Cureus</source>. (<year>2022</year>) <volume>14</volume>:<fpage>e22119</fpage>. doi: <pub-id pub-id-type="doi">10.7759/cureus.22119</pub-id></mixed-citation></ref>
<ref id="ref17"><label>17.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Daniels</surname><given-names>SR</given-names></name></person-group>. <article-title>The use of BMI in the clinical setting</article-title>. <source>Pediatrics</source>. (<year>2009</year>) <volume>124</volume>:<fpage>S35</fpage>&#x2013;<lpage>41</lpage>. doi: <pub-id pub-id-type="doi">10.1542/peds.2008-3586F</pub-id></mixed-citation></ref>
<ref id="ref18"><label>18.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Giudici</surname><given-names>P</given-names></name> <name><surname>Raffinetti</surname><given-names>E</given-names></name></person-group>. <article-title>Shapley-Lorenz eXplainable artificial intelligence</article-title>. <source>Expert Syst Appl</source>. (<year>2021</year>) <volume>167</volume>:<fpage>114104</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.eswa.2020.114104</pub-id></mixed-citation></ref>
<ref id="ref19"><label>19.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>H</given-names></name> <name><surname>Liang</surname><given-names>Q</given-names></name> <name><surname>Hancock</surname><given-names>JT</given-names></name> <name><surname>Khoshgoftaar</surname><given-names>TM</given-names></name></person-group>. <article-title>Feature selection strategies: a comparative analysis of SHAP-value and importance-based methods</article-title>. <source>J Big Data</source>. (<year>2024</year>) <volume>11</volume>:<fpage>44</fpage>. doi: <pub-id pub-id-type="doi">10.1186/s40537-024-00905-w</pub-id></mixed-citation></ref>
<ref id="ref20"><label>20.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhen</surname><given-names>S</given-names></name> <name><surname>Ma</surname><given-names>Y</given-names></name> <name><surname>Zhao</surname><given-names>Z</given-names></name> <name><surname>Yang</surname><given-names>X</given-names></name> <name><surname>Wen</surname><given-names>D</given-names></name></person-group>. <article-title>Dietary pattern is associated with obesity in Chinese children and adolescents: data from China health and nutrition survey (CHNS)</article-title>. <source>Nutr J</source>. (<year>2018</year>) <volume>17</volume>:<fpage>68</fpage>. doi: <pub-id pub-id-type="doi">10.1186/s12937-018-0372-8</pub-id>, <pub-id pub-id-type="pmid">29996840</pub-id></mixed-citation></ref>
<ref id="ref21"><label>21.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhu</surname><given-names>Z</given-names></name> <name><surname>Yin</surname><given-names>P</given-names></name></person-group>. <article-title>Overweight and obesity: the serious challenge faced by Chinese children and adolescents</article-title>. <source>J Glob Health</source>. (<year>2023</year>) <volume>13</volume>:<fpage>03036</fpage>. doi: <pub-id pub-id-type="doi">10.7189/jogh.13.03036</pub-id>, <pub-id pub-id-type="pmid">37469286</pub-id></mixed-citation></ref>
<ref id="ref22"><label>22.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>Y</given-names></name> <name><surname>Goodacre</surname><given-names>R</given-names></name></person-group>. <article-title>On splitting training and validation set: a comparative study of cross-validation, bootstrap and systematic sampling for estimating the generalization performance of supervised learning</article-title>. <source>J Anal Test</source>. (<year>2018</year>) <volume>2</volume>:<fpage>249</fpage>&#x2013;<lpage>62</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s41664-018-0068-2</pub-id>, <pub-id pub-id-type="pmid">30842888</pub-id></mixed-citation></ref>
<ref id="ref23"><label>23.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gupta</surname><given-names>M</given-names></name> <name><surname>Phan</surname><given-names>T-LT</given-names></name> <name><surname>Bunnell</surname><given-names>HT</given-names></name> <name><surname>Beheshti</surname><given-names>R</given-names></name></person-group>. <article-title>Obesity prediction with EHR data: a deep learning approach with interpretable elements</article-title>. <source>ACM Trans Comput Healthcare</source>. (<year>2022</year>) <volume>3</volume>:<fpage>1</fpage>&#x2013;<lpage>19</lpage>. doi: <pub-id pub-id-type="doi">10.1145/3506719</pub-id>, <pub-id pub-id-type="pmid">35756858</pub-id></mixed-citation></ref>
<ref id="ref24"><label>24.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>S</given-names></name> <name><surname>Chun</surname><given-names>J</given-names></name></person-group>. <article-title>Identification of important features in overweight and obesity among Korean adolescents using machine learning</article-title>. <source>Child Youth Serv Rev</source>. (<year>2024</year>) <volume>161</volume>:<fpage>107644</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.childyouth.2024.107644</pub-id></mixed-citation></ref>
<ref id="ref25"><label>25.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rudin</surname><given-names>C</given-names></name></person-group>. <article-title>Stop explaining black box machine learning models for high stakes decisions and use interpretable models instead</article-title>. <source>Nat Mach Intell</source>. (<year>2019</year>) <volume>1</volume>:<fpage>206</fpage>&#x2013;<lpage>15</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s42256-019-0048-x</pub-id>, <pub-id pub-id-type="pmid">35603010</pub-id></mixed-citation></ref>
<ref id="ref26"><label>26.</label><mixed-citation publication-type="confproc"><person-group person-group-type="author"><name><surname>Ester</surname><given-names>M</given-names></name> <name><surname>Kriegel</surname><given-names>H</given-names></name> <name><surname>Xu</surname><given-names>X</given-names></name></person-group>. <chapter-title>Xgboost: a scalable tree boosting system</chapter-title>. In <conf-name>Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining</conf-name> (<volume>785</volume>, <fpage>2016</fpage>). (<year>2022</year>).</mixed-citation></ref>
<ref id="ref27"><label>27.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ke</surname><given-names>G</given-names></name> <name><surname>Meng</surname><given-names>Q</given-names></name> <name><surname>Finley</surname><given-names>T</given-names></name> <etal/></person-group>. <article-title>LightGBM: a highly efficient gradient boosting decision tree</article-title>. <source>Adv Neural Inf Proces Syst</source>. (<year>2017</year>) <volume>30</volume></mixed-citation></ref>
<ref id="ref28"><label>28.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Breiman</surname><given-names>L</given-names></name></person-group>. <article-title>Random forests</article-title>. <source>Mach Learn</source>. (<year>2001</year>) <volume>45</volume>:<fpage>5</fpage>&#x2013;<lpage>32</lpage>. doi: <pub-id pub-id-type="doi">10.1023/a:1010933404324</pub-id></mixed-citation></ref>
<ref id="ref29"><label>29.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hornik</surname><given-names>K</given-names></name> <name><surname>Stinchcombe</surname><given-names>M</given-names></name> <name><surname>White</surname><given-names>H</given-names></name></person-group>. <article-title>Multilayer feedforward networks are universal approximators</article-title>. <source>Neural Netw</source>. (<year>1989</year>) <volume>2</volume>:<fpage>359</fpage>&#x2013;<lpage>66</lpage>. doi: <pub-id pub-id-type="doi">10.1016/0893-6080(89)90020-8</pub-id></mixed-citation></ref>
<ref id="ref30"><label>30.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lundberg</surname><given-names>SM</given-names></name> <name><surname>Erion</surname><given-names>G</given-names></name> <name><surname>Chen</surname><given-names>H</given-names></name> <name><surname>DeGrave</surname><given-names>A</given-names></name> <name><surname>Prutkin</surname><given-names>JM</given-names></name> <name><surname>Nair</surname><given-names>B</given-names></name> <etal/></person-group>. <article-title>From local explanations to global understanding with explainable Ai for trees</article-title>. <source>Nat Mach Intell</source>. (<year>2020</year>) <volume>2</volume>:<fpage>56</fpage>&#x2013;<lpage>67</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s42256-019-0138-9</pub-id>, <pub-id pub-id-type="pmid">32607472</pub-id></mixed-citation></ref>
<ref id="ref31"><label>31.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guo</surname><given-names>Y</given-names></name> <name><surname>Yin</surname><given-names>X</given-names></name> <name><surname>Wu</surname><given-names>H</given-names></name> <name><surname>Chai</surname><given-names>X</given-names></name> <name><surname>Yang</surname><given-names>X</given-names></name></person-group>. <article-title>Trends in overweight and obesity among children and adolescents in China from 1991 to 2015: a meta-analysis</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2019</year>) <volume>16</volume>:<fpage>4656</fpage>. doi: <pub-id pub-id-type="doi">10.3390/ijerph16234656</pub-id>, <pub-id pub-id-type="pmid">31766709</pub-id></mixed-citation></ref>
<ref id="ref32"><label>32.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hong</surname><given-names>Y</given-names></name> <name><surname>Ullah</surname><given-names>R</given-names></name> <name><surname>Wang</surname><given-names>J-B</given-names></name> <name><surname>Fu</surname><given-names>JF</given-names></name></person-group>. <article-title>Trends of obesity and overweight among children and adolescents in China</article-title>. <source>World J Pediatr</source>. (<year>2023</year>) <volume>19</volume>:<fpage>1115</fpage>&#x2013;<lpage>26</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s12519-023-00709-7</pub-id>, <pub-id pub-id-type="pmid">36920656</pub-id></mixed-citation></ref>
<ref id="ref33"><label>33.</label><mixed-citation publication-type="confproc"><person-group person-group-type="author"><name><surname>Yacouby</surname><given-names>R</given-names></name> <name><surname>Axman</surname><given-names>D</given-names></name></person-group>. <chapter-title>Probabilistic extension of precision, recall, and F1 score for more thorough evaluation of classification models</chapter-title>; In <conf-name>Proceedings of the First Workshop on Evaluation and Comparison of NLP Systems</conf-name>, (<year>2020</year>).</mixed-citation></ref>
<ref id="ref34"><label>34.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vickers</surname><given-names>AJ</given-names></name> <name><surname>Holland</surname><given-names>F</given-names></name></person-group>. <article-title>Decision curve analysis to evaluate the clinical benefit of prediction models</article-title>. <source>Spine J</source>. (<year>2021</year>) <volume>21</volume>:<fpage>1643</fpage>&#x2013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.spinee.2021.02.024</pub-id>, <pub-id pub-id-type="pmid">33676020</pub-id></mixed-citation></ref>
<ref id="ref35"><label>35.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zheng</surname><given-names>M</given-names></name> <name><surname>Zhang</surname><given-names>Y</given-names></name> <name><surname>Laws</surname><given-names>RA</given-names></name> <name><surname>Vuillermin</surname><given-names>P</given-names></name> <name><surname>Dodd</surname><given-names>J</given-names></name> <name><surname>Wen</surname><given-names>LM</given-names></name> <etal/></person-group>. <article-title>Development of machine learning-based risk prediction models to predict rapid weight gain in infants: analysis of seven cohorts</article-title>. <source>JMIR Public Health Surveill</source>. (<year>2025</year>) <volume>11</volume>:<fpage>e69220</fpage>. doi: <pub-id pub-id-type="doi">10.2196/69220</pub-id></mixed-citation></ref>
<ref id="ref36"><label>36.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liou</surname><given-names>YM</given-names></name> <name><surname>Liou</surname><given-names>TH</given-names></name> <name><surname>Chang</surname><given-names>LC</given-names></name></person-group>. <article-title>Obesity among adolescents: sedentary leisure time and sleeping as determinants</article-title>. <source>J Adv Nurs</source>. (<year>2010</year>) <volume>66</volume>:<fpage>1246</fpage>&#x2013;<lpage>56</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1365-2648.2010.05293.x</pub-id>, <pub-id pub-id-type="pmid">20546358</pub-id></mixed-citation></ref>
<ref id="ref37"><label>37.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baur</surname><given-names>LA</given-names></name></person-group>. <article-title>Child and adolescent obesity in the 21st century: an Australian perspective</article-title>. <source>Asia Pac J Clin Nutr</source>. (<year>2002</year>) <volume>11 Suppl 3</volume>:<fpage>S524</fpage>&#x2013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.1046/j.1440-6047.11.supp3.9.x</pub-id>, <pub-id pub-id-type="pmid">12492643</pub-id></mixed-citation></ref>
<ref id="ref38"><label>38.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thibault</surname><given-names>H</given-names></name> <name><surname>Contrand</surname><given-names>B</given-names></name> <name><surname>Saubusse</surname><given-names>E</given-names></name> <name><surname>Baine</surname><given-names>M</given-names></name> <name><surname>Maurice-Tison</surname><given-names>S</given-names></name></person-group>. <article-title>Associated factors for overweight and obesity in French adolescents: physical activity, sedentary behavior and parental characteristics</article-title>. <source>Nutrition</source>. (<year>2010</year>) <volume>26</volume>:<fpage>192</fpage>&#x2013;<lpage>200</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.nut.2009.03.015</pub-id>, <pub-id pub-id-type="pmid">19577429</pub-id></mixed-citation></ref>
<ref id="ref39"><label>39.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fernandes</surname><given-names>RA</given-names></name> <name><surname>Christofaro</surname><given-names>DGD</given-names></name> <name><surname>Cardoso</surname><given-names>JR</given-names></name> <name><surname>Ronque</surname><given-names>ERV</given-names></name> <name><surname>Freitas J&#x00FA;nior</surname><given-names>IF</given-names></name> <name><surname>Kawaguti</surname><given-names>SS</given-names></name> <etal/></person-group>. <article-title>Socioeconomic status as determinant of associated factors for overweight in adolescents</article-title>. <source>Ciencia Saude Coletiva</source>. (<year>2011</year>) <volume>16</volume>:<fpage>4051</fpage>&#x2013;<lpage>7</lpage>. doi: <pub-id pub-id-type="doi">10.1590/S1413-81232011001100010</pub-id>, <pub-id pub-id-type="pmid">22031134</pub-id></mixed-citation></ref>
<ref id="ref40"><label>40.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gallego</surname><given-names>A</given-names></name> <name><surname>L&#x00F3;pez-Gil</surname><given-names>JF</given-names></name></person-group>. <article-title>The role of individual and contextual economic factors in obesity among adolescents: a cross-sectional study including 143 160 participants from 41 countries</article-title>. <source>J Glob Health</source>. (<year>2024</year>) <volume>14</volume>:<fpage>04035</fpage>. doi: <pub-id pub-id-type="doi">10.7189/jogh.14.04035</pub-id>, <pub-id pub-id-type="pmid">38389438</pub-id></mixed-citation></ref>
<ref id="ref41"><label>41.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schneider</surname><given-names>D</given-names></name></person-group>. <article-title>International trends in adolescent nutrition</article-title>. <source>Soc Sci Med</source>. (<year>2000</year>) <volume>51</volume>:<fpage>955</fpage>&#x2013;<lpage>67</lpage>. doi: <pub-id pub-id-type="doi">10.1016/s0277-9536(00)00074-5</pub-id>, <pub-id pub-id-type="pmid">10972438</pub-id></mixed-citation></ref>
<ref id="ref42"><label>42.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ruiz</surname><given-names>LD</given-names></name> <name><surname>Zuelch</surname><given-names>ML</given-names></name> <name><surname>Dimitratos</surname><given-names>SM</given-names></name> <name><surname>Scherr</surname><given-names>RE</given-names></name></person-group>. <article-title>Adolescent obesity: diet quality, psychosocial health, and cardiometabolic associated factors</article-title>. <source>Nutrients</source>. (<year>2019</year>) <volume>12</volume>:<fpage>43</fpage>. doi: <pub-id pub-id-type="doi">10.3390/nu12010043</pub-id></mixed-citation></ref>
<ref id="ref43"><label>43.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gan</surname><given-names>WY</given-names></name> <name><surname>Mohamed</surname><given-names>SF</given-names></name> <name><surname>Law</surname><given-names>LS</given-names></name></person-group>. <article-title>Unhealthy lifestyle associated with higher intake of sugar-sweetened beverages among Malaysian school-aged adolescents</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2019</year>) <volume>16</volume>:<fpage>2785</fpage>. doi: <pub-id pub-id-type="doi">10.3390/ijerph16152785</pub-id>, <pub-id pub-id-type="pmid">31382672</pub-id></mixed-citation></ref>
<ref id="ref44"><label>44.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gao</surname><given-names>Y</given-names></name> <name><surname>Chen</surname><given-names>X</given-names></name> <name><surname>Li</surname><given-names>T</given-names></name> <name><surname>Chen</surname><given-names>F</given-names></name></person-group>. <article-title>Differences in pupils&#x2019; school commute characteristics and mode choice based on the household registration system in China</article-title>. <source>Case Stud Transp Policy</source>. (<year>2017</year>) <volume>5</volume>:<fpage>656</fpage>&#x2013;<lpage>61</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.cstp.2017.07.008</pub-id></mixed-citation></ref>
<ref id="ref45"><label>45.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Faulkner</surname><given-names>GE</given-names></name> <name><surname>Buliung</surname><given-names>RN</given-names></name> <name><surname>Flora</surname><given-names>PK</given-names></name> <name><surname>Fusco</surname><given-names>C</given-names></name></person-group>. <article-title>Active school transport, physical activity levels and body weight of children and youth: a systematic review</article-title>. <source>Prev Med</source>. (<year>2009</year>) <volume>48</volume>:<fpage>3</fpage>&#x2013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.ypmed.2008.10.017</pub-id>, <pub-id pub-id-type="pmid">19014963</pub-id></mixed-citation></ref>
<ref id="ref46"><label>46.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Formisano</surname><given-names>A</given-names></name> <name><surname>Hunsberger</surname><given-names>M</given-names></name> <name><surname>Bammann</surname><given-names>K</given-names></name> <name><surname>Vanaelst</surname><given-names>B</given-names></name> <name><surname>Molnar</surname><given-names>D</given-names></name> <name><surname>Moreno</surname><given-names>LA</given-names></name> <etal/></person-group>. <article-title>Family structure and childhood obesity: results of the IDEFICS project</article-title>. <source>Public Health Nutr</source>. (<year>2014</year>) <volume>17</volume>:<fpage>2307</fpage>&#x2013;<lpage>15</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S1368980013002474</pub-id>, <pub-id pub-id-type="pmid">24053908</pub-id></mixed-citation></ref>
<ref id="ref47"><label>47.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hunsberger</surname><given-names>M</given-names></name> <name><surname>Formisano</surname><given-names>A</given-names></name> <name><surname>Reisch</surname><given-names>LA</given-names></name> <name><surname>Bammann</surname><given-names>K</given-names></name> <name><surname>Moreno</surname><given-names>L</given-names></name> <name><surname>de Henauw</surname><given-names>S</given-names></name> <etal/></person-group>. <article-title>Overweight in singletons compared to children with siblings: the IDEFICS study</article-title>. <source>Nutr Diabetes</source>. (<year>2012</year>) <volume>2</volume>:<fpage>e35</fpage>&#x2013;<lpage>e</lpage>. doi: <pub-id pub-id-type="doi">10.1038/nutd.2012.8</pub-id></mixed-citation></ref>
<ref id="ref48"><label>48.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fang</surname><given-names>K</given-names></name> <name><surname>Mu</surname><given-names>M</given-names></name> <name><surname>Liu</surname><given-names>K</given-names></name> <name><surname>He</surname><given-names>Y</given-names></name></person-group>. <article-title>Screen time and childhood overweight/obesity: a systematic review and meta-analysis</article-title>. <source>Child Care Health Dev</source>. (<year>2019</year>) <volume>45</volume>:<fpage>744</fpage>&#x2013;<lpage>53</lpage>. doi: <pub-id pub-id-type="doi">10.1111/cch.12701</pub-id>, <pub-id pub-id-type="pmid">31270831</pub-id></mixed-citation></ref>
<ref id="ref49"><label>49.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tschann</surname><given-names>JM</given-names></name> <name><surname>Martinez</surname><given-names>SM</given-names></name> <name><surname>Penilla</surname><given-names>C</given-names></name> <name><surname>Gregorich</surname><given-names>SE</given-names></name> <name><surname>Pasch</surname><given-names>LA</given-names></name> <name><surname>de Groat</surname><given-names>CL</given-names></name> <etal/></person-group>. <article-title>Parental feeding practices and child weight status in Mexican American families: a longitudinal analysis</article-title>. <source>Int J Behav Nutr Phys Act</source>. (<year>2015</year>) <volume>12</volume>:<fpage>66</fpage>. doi: <pub-id pub-id-type="doi">10.1186/s12966-015-0224-2</pub-id>, <pub-id pub-id-type="pmid">25986057</pub-id></mixed-citation></ref>
<ref id="ref50"><label>50.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cai</surname><given-names>L</given-names></name> <name><surname>Lin</surname><given-names>L</given-names></name> <name><surname>Dai</surname><given-names>M</given-names></name> <name><surname>Chen</surname><given-names>Y</given-names></name> <name><surname>Li</surname><given-names>X</given-names></name> <name><surname>Ma</surname><given-names>J</given-names></name> <etal/></person-group>. <article-title>One-child policy, weight status, lifestyles and parental concerns in Chinese children: a nationwide cross-sectional survey</article-title>. <source>Eur J Clin Nutr</source>. (<year>2018</year>) <volume>72</volume>:<fpage>1150</fpage>&#x2013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41430-018-0178-y</pub-id>, <pub-id pub-id-type="pmid">29748661</pub-id></mixed-citation></ref>
<ref id="ref51"><label>51.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yusoff</surname><given-names>ZM</given-names></name> <name><surname>Shamin</surname><given-names>F</given-names></name> <name><surname>Arif</surname><given-names>H</given-names></name> <name><surname>Adnan</surname><given-names>NA</given-names></name> <name><surname>Nordin</surname><given-names>NA</given-names></name> <etal/></person-group>. <article-title>School location and mobility effects to obesity cases among primary school children</article-title>. <source>Adv Sci Lett</source>. (<year>2017</year>) <volume>23</volume>:<fpage>6377</fpage>&#x2013;<lpage>6380</lpage>. doi: <pub-id pub-id-type="doi">10.1166/asl.2017.9273</pub-id></mixed-citation></ref>
<ref id="ref52"><label>52.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Williams</surname><given-names>J</given-names></name> <name><surname>Scarborough</surname><given-names>P</given-names></name> <name><surname>Townsend</surname><given-names>N</given-names></name> <name><surname>Matthews</surname><given-names>A</given-names></name> <name><surname>Burgoine</surname><given-names>T</given-names></name> <name><surname>Mumtaz</surname><given-names>L</given-names></name> <etal/></person-group>. <article-title>Associations between food outlets around schools and Bmi among primary students in England: a cross-classified multi-level analysis</article-title>. <source>PLoS One</source>. (<year>2015</year>) <volume>10</volume>:<fpage>e0132930</fpage>. doi: <pub-id pub-id-type="doi">10.1371/journal.pone.0132930</pub-id>, <pub-id pub-id-type="pmid">26186610</pub-id></mixed-citation></ref>
<ref id="ref53"><label>53.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Day</surname><given-names>PL</given-names></name> <name><surname>Pearce</surname><given-names>J</given-names></name></person-group>. <article-title>Obesity-promoting food environments and the spatial clustering of food outlets around schools</article-title>. <source>Am J Prev Med</source>. (<year>2011</year>) <volume>40</volume>:<fpage>113</fpage>&#x2013;<lpage>21</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.amepre.2010.10.018</pub-id>, <pub-id pub-id-type="pmid">21238858</pub-id></mixed-citation></ref>
<ref id="ref54"><label>54.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hills</surname><given-names>AP</given-names></name> <name><surname>Dengel</surname><given-names>DR</given-names></name> <name><surname>Lubans</surname><given-names>DR</given-names></name></person-group>. <article-title>Supporting public health priorities: recommendations for physical education and physical activity promotion in schools</article-title>. <source>Prog Cardiovasc Dis</source>. (<year>2015</year>) <volume>57</volume>:<fpage>368</fpage>&#x2013;<lpage>74</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.pcad.2014.09.010</pub-id>, <pub-id pub-id-type="pmid">25269062</pub-id></mixed-citation></ref>
<ref id="ref55"><label>55.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fernandes</surname><given-names>M</given-names></name> <name><surname>Sturm</surname><given-names>R</given-names></name></person-group>. <article-title>Facility provision in elementary schools: correlates with physical education, recess, and obesity</article-title>. <source>Prev Med</source>. (<year>2010</year>) <volume>50</volume>:<fpage>S30</fpage>&#x2013;<lpage>5</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.ypmed.2009.09.022</pub-id></mixed-citation></ref>
<ref id="ref56"><label>56.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>In-Iw</surname><given-names>S</given-names></name> <name><surname>Saetae</surname><given-names>T</given-names></name> <name><surname>Manaboriboon</surname><given-names>B</given-names></name></person-group>. <article-title>The effectiveness of school-based nutritional education program among obese adolescents: a randomized controlled study</article-title>. <source>Int J Pediatr</source>. (<year>2012</year>) <volume>2012</volume>:<fpage>608920</fpage>. doi: <pub-id pub-id-type="doi">10.1155/2012/608920</pub-id></mixed-citation></ref>
<ref id="ref57"><label>57.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jaime</surname><given-names>PC</given-names></name> <name><surname>Lock</surname><given-names>K</given-names></name></person-group>. <article-title>Do school based food and nutrition policies improve diet and reduce obesity?</article-title> <source>Prev Med</source>. (<year>2009</year>) <volume>48</volume>:<fpage>45</fpage>&#x2013;<lpage>53</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.ypmed.2008.10.018</pub-id>, <pub-id pub-id-type="pmid">19026676</pub-id></mixed-citation></ref>
<ref id="ref58"><label>58.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>S-F</given-names></name> <name><surname>Shu</surname><given-names>L</given-names></name> <name><surname>Sheng</surname><given-names>J</given-names></name> <name><surname>Mu</surname><given-names>M</given-names></name> <name><surname>Wang</surname><given-names>S</given-names></name> <name><surname>Tao</surname><given-names>X-Y</given-names></name> <etal/></person-group>. <article-title>Birth weight and risk of coronary heart disease in adults: a meta-analysis of prospective cohort studies</article-title>. <source>J Dev Orig Health Dis</source>. (<year>2014</year>) <volume>5</volume>:<fpage>408</fpage>&#x2013;<lpage>19</lpage>. doi: <pub-id pub-id-type="doi">10.1017/s2040174414000440</pub-id>, <pub-id pub-id-type="pmid">25263759</pub-id></mixed-citation></ref>
<ref id="ref59"><label>59.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rossi</surname><given-names>CE</given-names></name> <name><surname>Vasconcelos</surname><given-names>FDAGD</given-names></name></person-group>. <article-title>Birth weight and obesity in children and adolescents: a systematic review</article-title>. <source>Rev Bras Epidemiol</source>. (<year>2010</year>) <volume>13</volume>:<fpage>246</fpage>&#x2013;<lpage>58</lpage>. doi: <pub-id pub-id-type="doi">10.1590/S1415-790X2010000200007</pub-id></mixed-citation></ref>
<ref id="ref60"><label>60.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>Z</given-names></name> <name><surname>Han</surname><given-names>S</given-names></name> <name><surname>Zhu</surname><given-names>G</given-names></name> <name><surname>Zhu</surname><given-names>C</given-names></name> <name><surname>Wang</surname><given-names>XJ</given-names></name> <name><surname>Cao</surname><given-names>XG</given-names></name> <etal/></person-group>. <article-title>Birth weight and subsequent risk of obesity: a systematic review and meta-analysis</article-title>. <source>Obes Rev</source>. (<year>2011</year>) <volume>12</volume>:<fpage>525</fpage>&#x2013;<lpage>42</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1467-789X.2011.00867.x</pub-id>, <pub-id pub-id-type="pmid">21438992</pub-id></mixed-citation></ref>
<ref id="ref61"><label>61.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paliy</surname><given-names>O</given-names></name> <name><surname>Piyathilake</surname><given-names>CJ</given-names></name> <name><surname>Kozyrskyj</surname><given-names>A</given-names></name> <name><surname>Celep</surname><given-names>G</given-names></name> <name><surname>Marotta</surname><given-names>F</given-names></name> <name><surname>Rastmanesh</surname><given-names>R</given-names></name></person-group>. <article-title>Excess body weight during pregnancy and offspring obesity: potential mechanisms</article-title>. <source>Nutrition</source>. (<year>2014</year>) <volume>30</volume>:<fpage>245</fpage>&#x2013;<lpage>51</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.nut.2013.05.011</pub-id>, <pub-id pub-id-type="pmid">24103493</pub-id></mixed-citation></ref>
<ref id="ref62"><label>62.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mcdonald</surname><given-names>CM</given-names></name> <name><surname>Baylin</surname><given-names>A</given-names></name> <name><surname>Joanne</surname><given-names>EA</given-names></name> <name><surname>Mercedes</surname><given-names>M-P</given-names></name> <name><surname>Eduardo</surname><given-names>V</given-names></name></person-group>. <article-title>Overweight is more prevalent than stunting and is associated with socioeconomic status, maternal obesity, and a snacking dietary pattern in school children from Bogota, Colombia</article-title>. <source>J Nutr</source>. (<year>2009</year>) <volume>139</volume>:<fpage>370</fpage>&#x2013;<lpage>6</lpage>. doi: <pub-id pub-id-type="doi">10.3945/jn.108.098111</pub-id>, <pub-id pub-id-type="pmid">19106320</pub-id></mixed-citation></ref>
<ref id="ref63"><label>63.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>&#x00D8;rskou</surname><given-names>J</given-names></name> <name><surname>Henriksen</surname><given-names>TB</given-names></name> <name><surname>Kesmodel</surname><given-names>U</given-names></name> <name><surname>Secher</surname><given-names>NJ</given-names></name></person-group>. <article-title>Maternal characteristics and lifestyle factors and the risk of delivering high birth weight infants</article-title>. <source>Obstet Gynecol</source>. (<year>2003</year>) <volume>102</volume>:<fpage>115</fpage>&#x2013;<lpage>20</lpage>. doi: <pub-id pub-id-type="doi">10.1097/00006250-200307000-00022</pub-id>, <pub-id pub-id-type="pmid">12850616</pub-id></mixed-citation></ref>
<ref id="ref64"><label>64.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bray</surname><given-names>GA</given-names></name> <name><surname>Bouchard</surname><given-names>C</given-names></name></person-group>. <article-title>The biology of human overfeeding: a systematic review</article-title>. <source>Obes Rev</source>. (<year>2020</year>) <volume>21</volume>:<fpage>e13040</fpage>. doi: <pub-id pub-id-type="doi">10.1111/obr.13040</pub-id>, <pub-id pub-id-type="pmid">32515127</pub-id></mixed-citation></ref>
<ref id="ref65"><label>65.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Abbott</surname><given-names>BD</given-names></name> <name><surname>Barber</surname><given-names>BL</given-names></name></person-group>. <article-title>Embodied image: gender differences in functional and aesthetic body image among Australian adolescents</article-title>. <source>Body Image</source>. (<year>2010</year>) <volume>7</volume>:<fpage>22</fpage>&#x2013;<lpage>31</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.bodyim.2009.10.004</pub-id>, <pub-id pub-id-type="pmid">19945925</pub-id></mixed-citation></ref>
<ref id="ref66"><label>66.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barker</surname><given-names>ET</given-names></name> <name><surname>Galambos</surname><given-names>NL</given-names></name></person-group>. <article-title>Body dissatisfaction of adolescent girls and boys: risk and resource factors</article-title>. <source>J Early Adolesc</source>. (<year>2003</year>) <volume>23</volume>:<fpage>141</fpage>&#x2013;<lpage>65</lpage>. doi: <pub-id pub-id-type="doi">10.1177/0272431603023002002</pub-id></mixed-citation></ref>
<ref id="ref67"><label>67.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>O'dea</surname><given-names>JA</given-names></name></person-group>. <article-title>School-based health education strategies for the improvement of body image and prevention of eating problems: an overview of safe and successful interventions</article-title>. <source>Health Educ</source>. (<year>2005</year>) <volume>105</volume>:<fpage>11</fpage>&#x2013;<lpage>33</lpage>. doi: <pub-id pub-id-type="doi">10.1108/09654280510572277</pub-id></mixed-citation></ref>
<ref id="ref68"><label>68.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ouyang</surname><given-names>Y</given-names></name> <name><surname>Wang</surname><given-names>K</given-names></name> <name><surname>Zhang</surname><given-names>T</given-names></name> <name><surname>Peng</surname><given-names>L</given-names></name> <name><surname>Song</surname><given-names>G</given-names></name> <name><surname>Luo</surname><given-names>J</given-names></name></person-group>. <article-title>The influence of sports participation on body image, self-efficacy, and self-esteem in college students</article-title>. <source>Front Psychol</source>. (<year>2020</year>) <volume>10</volume>:<fpage>3039</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fpsyg.2019.03039</pub-id>, <pub-id pub-id-type="pmid">32116869</pub-id></mixed-citation></ref>
<ref id="ref69"><label>69.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hemmingsson</surname><given-names>E</given-names></name></person-group>. <article-title>A new model of the role of psychological and emotional distress in promoting obesity: conceptual review with implications for treatment and prevention</article-title>. <source>Obes Rev</source>. (<year>2014</year>) <volume>15</volume>:<fpage>769</fpage>&#x2013;<lpage>79</lpage>. doi: <pub-id pub-id-type="doi">10.1111/obr.12197</pub-id>, <pub-id pub-id-type="pmid">24931366</pub-id></mixed-citation></ref>
<ref id="ref70"><label>70.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shriver</surname><given-names>LH</given-names></name> <name><surname>Dollar</surname><given-names>JM</given-names></name> <name><surname>Calkins</surname><given-names>SD</given-names></name> <name><surname>Keane</surname><given-names>SP</given-names></name> <name><surname>Shanahan</surname><given-names>L</given-names></name> <name><surname>Wideman</surname><given-names>L</given-names></name></person-group>. <article-title>Emotional eating in adolescence: effects of emotion regulation, weight status and negative body image</article-title>. <source>Nutrients</source>. (<year>2020</year>) <volume>13</volume>:<fpage>79</fpage>. doi: <pub-id pub-id-type="doi">10.3390/nu13010079</pub-id>, <pub-id pub-id-type="pmid">33383717</pub-id></mixed-citation></ref>
<ref id="ref71"><label>71.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><name><surname>Lyter</surname><given-names>PL</given-names></name></person-group>. <source>The relationship between the acceptance of the socially constructed ideal body image, body mass index, level of appearance satisfaction and weight management health behaviors in college women</source>. <publisher-loc>Michigan</publisher-loc>: <publisher-name>The University of Wisconsin-Madison</publisher-name> (<year>1997</year>).</mixed-citation></ref>
<ref id="ref72"><label>72.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wu</surname><given-names>HX</given-names></name> <name><surname>Ching</surname><given-names>BH-H</given-names></name> <name><surname>He</surname><given-names>CC</given-names></name> <name><surname>Li</surname><given-names>Y</given-names></name></person-group>. <article-title>&#x201C;Thinness is beauty&#x201D;: predictors of anti-fat attitudes among young Chinese women</article-title>. <source>Curr Psychol</source>. (<year>2021</year>) <volume>42</volume>:<fpage>6834</fpage>&#x2013;<lpage>45</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s12144-021-02021-x</pub-id></mixed-citation></ref>
<ref id="ref73"><label>73.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pate</surname><given-names>RR</given-names></name> <name><surname>Mitchell</surname><given-names>JA</given-names></name> <name><surname>Byun</surname><given-names>W</given-names></name> <name><surname>Dowda</surname><given-names>M</given-names></name></person-group>. <article-title>Sedentary behaviour in youth</article-title>. <source>Br J Sports Med</source>. (<year>2011</year>) <volume>45</volume>:<fpage>906</fpage>&#x2013;<lpage>13</lpage>. doi: <pub-id pub-id-type="doi">10.1136/bjsports-2011-090192</pub-id>, <pub-id pub-id-type="pmid">21836174</pub-id></mixed-citation></ref>
<ref id="ref74"><label>74.</label><mixed-citation publication-type="other"><person-group person-group-type="author"><name><surname>Barnett</surname><given-names>TA</given-names></name> <name><surname>Kelly</surname><given-names>AS</given-names></name> <name><surname>Young</surname><given-names>DR</given-names></name> <name><surname>Perry</surname><given-names>CK</given-names></name> <name><surname>Pratt</surname><given-names>CA</given-names></name> <name><surname>Edwards</surname><given-names>NM</given-names></name> <etal/></person-group>. <article-title>Sedentary behaviors in today&#x2019;s youth: approaches to the prevention and management of childhood obesity: a scientific statement from the American Heart Association[J]</article-title>. <source>Circulation</source>. (<year>2018</year>) <volume>138</volume>: <fpage>e142</fpage>&#x2013;<lpage>e159</lpage>. doi: <pub-id pub-id-type="doi">10.1161/CIR.0000000000000591</pub-id></mixed-citation></ref>
<ref id="ref75"><label>75.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dias</surname><given-names>PJP</given-names></name> <name><surname>Domingos</surname><given-names>IP</given-names></name> <name><surname>Ferreira</surname><given-names>MG</given-names></name> <name><surname>Muraro</surname><given-names>AP</given-names></name> <name><surname>Sichieri</surname><given-names>R</given-names></name> <name><surname>Gon&#x00E7;alves-Silva</surname><given-names>RMV</given-names></name></person-group>. <article-title>Preval&#x00EA;ncia e fatores associados aos comportamentos sedent&#x00E1;rios em adolescentes</article-title>. <source>Rev Saude Publica</source>. (<year>2014</year>) <volume>48</volume>:<fpage>266</fpage>&#x2013;<lpage>74</lpage>. doi: <pub-id pub-id-type="doi">10.1590/s0034-8910.2014048004635</pub-id>, <pub-id pub-id-type="pmid">24897048</pub-id></mixed-citation></ref>
<ref id="ref76"><label>76.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Molnar</surname><given-names>D</given-names></name> <name><surname>Schutz</surname><given-names>Y</given-names></name></person-group>. <article-title>The effect of obesity, age, puberty and gender on resting metabolic rate in children and adolescents</article-title>. <source>Eur J Pediatr</source>. (<year>1997</year>) <volume>156</volume>:<fpage>376</fpage>&#x2013;<lpage>81</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s004310050618</pub-id>, <pub-id pub-id-type="pmid">9177980</pub-id></mixed-citation></ref>
<ref id="ref77"><label>77.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tremblay</surname><given-names>MS</given-names></name> <name><surname>Aubert</surname><given-names>S</given-names></name> <name><surname>Barnes</surname><given-names>JD</given-names></name> <name><surname>Saunders</surname><given-names>TJ</given-names></name> <name><surname>Carson</surname><given-names>V</given-names></name> <name><surname>Latimer-Cheung</surname><given-names>AE</given-names></name> <etal/></person-group>. <article-title>Sedentary behavior research network (SBRN)&#x2013;terminology consensus project process and outcome</article-title>. <source>Int J Behav Nutr Phys Act</source>. (<year>2017</year>) <volume>14</volume>:<fpage>1</fpage>&#x2013;<lpage>17</lpage>. doi: <pub-id pub-id-type="doi">10.1186/s12966-017-0525-8</pub-id>, <pub-id pub-id-type="pmid">28599680</pub-id></mixed-citation></ref>
<ref id="ref78"><label>78.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>J</given-names></name> <name><surname>Shen</surname><given-names>Y</given-names></name> <name><surname>Quan</surname><given-names>X</given-names></name></person-group>. <article-title>Physical activity, screen time, and academic burden: a cross-sectional analysis of health among Chinese adolescents</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2023</year>) <volume>20</volume>:<fpage>4917</fpage>. doi: <pub-id pub-id-type="doi">10.3390/ijerph20064917</pub-id>, <pub-id pub-id-type="pmid">36981825</pub-id></mixed-citation></ref>
<ref id="ref79"><label>79.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhu</surname><given-names>X</given-names></name> <name><surname>Haegele</surname><given-names>JA</given-names></name> <name><surname>Liu</surname><given-names>H</given-names></name> <name><surname>Yu</surname><given-names>F</given-names></name></person-group>. <article-title>Academic stress, physical activity, sleep, and mental health among Chinese adolescents</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2021</year>) <volume>18</volume>:<fpage>7257</fpage>. doi: <pub-id pub-id-type="doi">10.3390/ijerph18147257</pub-id>, <pub-id pub-id-type="pmid">34299708</pub-id></mixed-citation></ref>
<ref id="ref80"><label>80.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Noor</surname><given-names>Z</given-names></name> <name><surname>Khaliq</surname><given-names>M</given-names></name> <name><surname>Khan</surname><given-names>AU</given-names></name> <name><surname>Ali</surname><given-names>MA</given-names></name> <name><surname>Tahir</surname><given-names>SK</given-names></name> <name><surname>Khaliq</surname><given-names>K</given-names></name></person-group>. <article-title>Academic stress and adolescent health: exploring eating patterns, dietary preferences, and sleep duration in Pakistan's youth</article-title>. <source>Appetite</source>. (<year>2025</year>) <volume>209</volume>:<fpage>107962</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.appet.2025.107962</pub-id>, <pub-id pub-id-type="pmid">40058607</pub-id></mixed-citation></ref>
<ref id="ref81"><label>81.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hills</surname><given-names>AP</given-names></name> <name><surname>Andersen</surname><given-names>LB</given-names></name> <name><surname>Byrne</surname><given-names>NM</given-names></name></person-group>. <article-title>Physical activity and obesity in children</article-title>. <source>Br J Sports Med</source>. (<year>2011</year>) <volume>45</volume>:<fpage>866</fpage>&#x2013;<lpage>70</lpage>. doi: <pub-id pub-id-type="doi">10.1136/bjsports-2011-090199</pub-id>, <pub-id pub-id-type="pmid">21836171</pub-id></mixed-citation></ref>
<ref id="ref82"><label>82.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vasconcellos</surname><given-names>F</given-names></name> <name><surname>Seabra</surname><given-names>A</given-names></name> <name><surname>Katzmarzyk</surname><given-names>PT</given-names></name> <name><surname>Kraemer-Aguiar</surname><given-names>LG</given-names></name> <name><surname>Bouskela</surname><given-names>E</given-names></name> <name><surname>Farinatti</surname><given-names>P</given-names></name></person-group>. <article-title>Physical activity in overweight and obese adolescents: systematic review of the effects on physical fitness components and cardiovascular associated factors</article-title>. <source>Sports Med</source>. (<year>2014</year>) <volume>44</volume>:<fpage>1139</fpage>&#x2013;<lpage>52</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s40279-014-0193-7</pub-id>, <pub-id pub-id-type="pmid">24743931</pub-id></mixed-citation></ref>
<ref id="ref83"><label>83.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sherry</surname><given-names>B</given-names></name> <name><surname>Jefferds</surname><given-names>ME</given-names></name> <name><surname>Grummer-Strawn</surname><given-names>LM</given-names></name></person-group>. <article-title>Accuracy of adolescent self-report of height and weight in assessing overweight status: a literature review</article-title>. <source>Arch Pediatr Adolesc Med</source>. (<year>2007</year>) <volume>161</volume>:<fpage>1154</fpage>&#x2013;<lpage>61</lpage>. doi: <pub-id pub-id-type="doi">10.1001/archpedi.161.12.1154</pub-id>, <pub-id pub-id-type="pmid">18056560</pub-id></mixed-citation></ref>
<ref id="ref84"><label>84.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhou</surname><given-names>X</given-names></name> <name><surname>Dibley</surname><given-names>MJ</given-names></name> <name><surname>Cheng</surname><given-names>Y</given-names></name> <name><surname>Ouyang</surname><given-names>X</given-names></name> <name><surname>Yan</surname><given-names>H</given-names></name></person-group>. <article-title>Validity of self-reported weight, height and resultant body mass index in Chinese adolescents and factors associated with errors in self-reports</article-title>. <source>BMC Public Health</source>. (<year>2010</year>) <volume>10</volume>:<fpage>190</fpage>. doi: <pub-id pub-id-type="doi">10.1186/1471-2458-10-190</pub-id></mixed-citation></ref>
<ref id="ref85"><label>85.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>W</given-names></name> <name><surname>Shi</surname><given-names>S</given-names></name> <name><surname>Huang</surname><given-names>H</given-names></name> <name><surname>Wen</surname><given-names>J</given-names></name> <name><surname>Chen</surname><given-names>G</given-names></name></person-group>. <article-title>Predicting risk of obesity in overweight adults using interpretable machine learning algorithms</article-title>. <source>Front Endocrinol (Lausanne)</source>. (<year>2023</year>) <volume>14</volume>:<fpage>1292167</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fendo.2023.1292167</pub-id></mixed-citation></ref>
<ref id="ref86"><label>86.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Miguel-Hurtado</surname><given-names>O</given-names></name> <name><surname>Guest</surname><given-names>R</given-names></name> <name><surname>Stevenage</surname><given-names>SV</given-names></name> <name><surname>Neil</surname><given-names>GJ</given-names></name> <name><surname>Black</surname><given-names>S</given-names></name></person-group>. <article-title>Comparing Machine Learning Classifiers and Linear/Logistic Regression to Explore the Relationship between Hand Dimensions and Demographic Characteristics</article-title>. <source>PLoS One</source>. (<year>2016</year>) <volume>11</volume>:<fpage>e0165521</fpage>. doi: <pub-id pub-id-type="doi">10.1371/journal.pone.0165521</pub-id></mixed-citation></ref>
</ref-list>
<fn-group>
<fn fn-type="custom" custom-type="edited-by" id="fn0002">
<p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3047076/overview">Shungen Huang</ext-link>, Children's Hospital of Soochow University, China</p>
</fn>
<fn fn-type="custom" custom-type="reviewed-by" id="fn0003">
<p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1347351/overview">Lina Zhang</ext-link>, Shenzhen Third People&#x2019;s Hospital, China</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2525814/overview">Mamoona Tasleem Afzal</ext-link>, Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Pakistan</p>
</fn>
</fn-group>
<fn-group>
<fn id="fn0001"><label>1</label><p><ext-link xlink:href="http://ceps.ruc.edu.cn" ext-link-type="uri">http://ceps.ruc.edu.cn</ext-link></p>
</fn>
</fn-group>
</back>
</article>