AUTHOR=Zheng Shuhan , Luo Feng , Su Ying , Liu Xinyu , Dai Rongrong , Deng Xuan , Zhu Yao , Zhou Yang , He Hanqing , Hua Chunzhen , Zhang Hangjie 

TITLE=Clinical characteristics and mortality risk factors among hospitalized infants and children with pertussis in China: a retrospective study

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1663885

DOI=10.3389/fpubh.2025.1663885

ISSN=2296-2565

ABSTRACT=BackgroundThe resurgence of pertussis has emerged as a significant global public health threat. Severe pertussis primarily affects infants and children and is often associated with serious complications or death.MethodsWe retrospectively evaluated the clinical data of 197 hospitalized children with pertussis admitted to Children’s Hospital, Zhejiang University School of Medicine, from 2019 to 2024. Patients were categorized into severe and mild cases groups based on their admission ward. Multivariate logistic model was applied to explore associated factors.ResultsAmong the 197 hospitalized children, those born prematurely or younger than 3 months were more likely to be admitted to the pediatric intensive care unit (PICU). All patients admitted to the PICU were infants who were either unvaccinated or incompletely vaccinated against pertussis. The most common clinical symptoms among hospitalized children were pneumonia, paroxysmal cough, and flushing. The severe cases group exhibited significantly higher levels than the mild cases group in length of stay, duration of antibiotic treatment, white blood cell (WBC) count, pneumonia, respiratory failure, and tachypnea (p < 0.05). Multivariate logistic regression analysis identified cefuroxime usage [odds ratio (OR) = 0.10, 95% confidence interval (CI) = 0.01–0.92], high WBC count (OR = 0.79, 95% CI = 0.69–0.91), and high neutrophil percentage (OR = 1.49, 95% CI = 1.22–1.82) as independent risk factors for PICU admission (p < 0.05).ConclusionInfants younger than 3 months and children who are unvaccinated or incompletely vaccinated for pertussis are more susceptible to developing severe pertussis. Common clinical features of severe pertussis include pneumonia, respiratory failure, elevated WBC count, and decreased neutrophil percentage. Pediatricians should prioritize early recognition and treatment of these clinical indicators to prevent the progression of severe pertussis.