AUTHOR=Himatt Sayed , Aziz Muna Abdel , ElDesouki Baher , Muehlen Marion , Malkawi Mazen , Pinto Julio , Al Nsour Mohannad , Khader Yousef , Bashier Haitham , Adam Shukri , Al Faouri Ibrahim TITLE=Advancing one health implementation in the Eastern Mediterranean region: insights from the EMPHNET 8th biennial roundtable JOURNAL=Frontiers in Public Health VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1652846 DOI=10.3389/fpubh.2025.1652846 ISSN=2296-2565 ABSTRACT=Countries in the Eastern Mediterranean region (EMR) face interconnected risks at the human, animal, and environmental interface. This Perspective synthesizes lessons from a roundtable convened during the EMPHNET 8th Biennial Regional Conference (Amman, 15–18 September 2024) to identify near-term actions to operationalize One Health. The two-hour session featured five presentations, a panel, and open discussion with 68 participants from human, animal, and environmental health, food safety, life sciences, and social sciences. Rapporteur notes and slides were independently reviewed by two authors and consolidated into cross-cutting themes. Five priorities emerged: workforce development and mentorship; governance and multisectoral coordination; surveillance, data integration, and joint risk assessment; financing and sustainability; and climate and environmental determinants. Participants emphasized Competencies for One Health Field Epidemiology (COHFE)-aligned competency pathways, institutionalized coordination with defined roles, interoperable surveillance products using shared case definitions, early joint risk assessments with explicit triggers, and sustained cross-sector rapid response capacity. They called for embedding One Health tasks in national budgets, aligning external support to government plans, and integrating health within climate policies and investments. Egypt case illustrated national organization of governance, surveillance, and financing. The roundtable offers a practice-oriented entry point for EMR decision makers to operationalize One Health in the near term.