AUTHOR=De Luca Vincenzo , Virgolesi Michele , Cuomo Alessandra , Lemmo Daniela , Perillo Mariangela , Canfora Federica , Aprano Sara , Mezza Fabrizio , Vetrani Claudia , Freda Maria Francesca , Adamo Daniela , Rea Teresa , Mercurio Lorenzo , Attaianese Erminia , Menditto Enrica , Colao Annamaria , Iaccarino Guido , Illario Maddalena 

TITLE=Digital interventions addressing the unmet needs of older adults with multimorbidity: a mixed-methods persona design approach

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1637748

DOI=10.3389/fpubh.2025.1637748

ISSN=2296-2565

ABSTRACT=BackgroundFrailty and multimorbidity in older adults require integrated, multidomain care models. Digital health solutions offer potential for improving self-management, but a structured methodology to translate the complex unmet needs of this population into tailored digital interventions is still lacking.ObjectivesTo propose and illustrate a mixed-methods, persona-based approach for mapping unmet needs of older adults with multimorbidity to candidate digital interventions.MethodsThis study employed an explanatory sequential mixed-methods design. First, quantitative data from the SUNFRAIL+ frailty screening tool were analyzed for a sub-cohort of community-dwelling older adults with polypharmacy (n = 54). These findings informed a qualitative phase conducted through a multidisciplinary Focus Group (FG) of 15 healthcare and social care experts. FG transcripts were thematically analyzed to identify unmet needs across clinical, psychological, social, and environmental domains. These insights were synthesized using the European Commission’s Blueprint methodology to create a realistic persona, “Gennaro,” representing common challenges. Finally, the FG systematically mapped potential digital solutions to address the identified needs. We descriptively profiled a polypharmacy subgroup (n = 54) from the F2UH site of the multicentre SUNFRAIL+ study; no hypothesis testing was performed.ResultsSUNFRAIL+ data revealed a high prevalence of perceived memory loss (44.4%), reduced physical activity (40.7%), loneliness (29.6%), and gaps in primary care access (25.9%). Thematic analysis highlighted unmet needs in medication management, motivation for lifestyle change, social isolation, and environmental barriers. The persona “Gennaro” embodied these challenges, facilitating the identification of targeted digital solutions, including Shared Care Plans, Telemonitoring, smart pillboxes for Medication Adherence, Adapted Physical Activity programs, Motivational Interviewing apps, and Ambient Assisted Living (AAL) systems. A foundational dataset and interoperability requirements for implementation were also defined.ConclusionThis descriptive, hypothesis-generating study integrates quantitative screening and multidisciplinary expert insights to propose a structured, persona-guided approach for profiling the multifaceted unmet needs of older adults with multimorbidity. We outline candidate digital options mapped to specific challenges as a preliminary framework to hypothesize person-centered, digitally supported care models. End-user co-design and validation are planned next to evaluate feasibility, usability, acceptability, and potential impact on self-management and adherence.