AUTHOR=Liu Yuanyuan , Zhang Xiaoyan , Cao Zhen , Zhu Shanshan , Fu Jianjun 

TITLE=Assessing the knowledge, attitudes, and psychological health of people who use drugs towards Hepatitis C: a cross-sectional study

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1618440

DOI=10.3389/fpubh.2025.1618440

ISSN=2296-2565

ABSTRACT=IntroductionUnderstanding the knowledge, risk behaviors, and psychological health of people who use drugs (PWUDs) is critical for Hepatitis C (HCV) elimination. This study aimed to assess these factors among PWUDs in a Drug Rehabilitation Center by comparing HCV-positive and HCV-negative individuals.MethodA total of 127 participants over 18 years (58 HCV-positive and 69 HCV-negative) were selected from the Lantian Drug Rehabilitation Center from April to June 2023. Data were collected through a descriptive, cross-sectional questionnaire (HCV awareness, HCV knowledge, SCL-90 tests) and laboratory blood tests, with which inferential and descriptive statistical analyses were performed.ResultsOf the 127 participants, 58 (45.7%) were HCV-positive. A significant portion of both HCV-positive (31.0%) and HCV-negative (66.7%) individuals were unaware of their status prior to testing (P = 0.04). Overall HCV knowledge was high and similar between the two groups, though specific gaps persisted, with fewer than 40% recognizing the transmission risk from unregulated cosmetic procedures. Sharing syringes was significantly more prevalent in the HCV-positive group (P = 0.001). Compared to Chinese national norms, HCV-positive PWUDs exhibited significantly higher psychological distress across all ten SCL-90 dimensions (all P < 0.001), with the most pronounced elevations in somatization and psychoticism.ConclusionEducational programs in rehabilitation centers appear effective in raising general HCV awareness, significant gaps in knowledge about community-based transmission routes persist. The profound psychological distress observed among HCV-positive PWUDs, coupled with the high rate of status unawareness, underscores the urgent need for integrated care models that address both virological treatment and mental health support.