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<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
<issn pub-type="epub">2296-2565</issn>
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<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2025.1513242</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health</subject>
<subj-group>
<subject>Systematic Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Alcohol consumption among university students in Ethiopia: a systematic review and meta-analysis of epidemiological studies</article-title>
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<surname>Debela</surname>
<given-names>Sisay Abebe</given-names>
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<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<xref ref-type="author-notes" rid="fn0001"><sup>&#x2020;</sup></xref>
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<name>
<surname>Tefera</surname>
<given-names>Yonatal Mesfin</given-names>
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<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="author-notes" rid="fn0001"><sup>&#x2020;</sup></xref>
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<name>
<surname>Debela</surname>
<given-names>Endashaw Abebe</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
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<contrib contrib-type="author">
<name>
<surname>Gebrehiwot</surname>
<given-names>Mesfin</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
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<contrib contrib-type="author">
<name>
<surname>Bezie</surname>
<given-names>Anmut Endalkachew</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref>
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<contrib contrib-type="author">
<name>
<surname>Dadi</surname>
<given-names>Ejeta Batu</given-names>
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<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
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<name>
<surname>Daba</surname>
<given-names>Chala</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
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<aff id="aff1"><sup>1</sup><institution>Department of Public Health, College of Medicine and Health Sciences, Salale University</institution>, <addr-line>Fiche</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff2"><sup>2</sup><institution>Adelaide Exposure Science and Health, School of Public Health, University of Adelaide</institution>, <addr-line>Adelaide, SA</addr-line>, <country>Australia</country></aff>
<aff id="aff3"><sup>3</sup><institution>School of Internal Medicine, Adama Hospital Medical College</institution>, <addr-line>Adama</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff4"><sup>4</sup><institution>Environmental Pollution Monitoring and Study Desk, Ethiopian Environmental Protection Authority</institution>, <addr-line>Addis Ababa</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff5"><sup>5</sup><institution>Department of Occupational Health and Safety, College of Medicine and Health Sciences, Wollo University</institution>, <addr-line>Dessie</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff6"><sup>6</sup><institution>Oromia Health Bureau</institution>, <addr-line>Addis Ababa</addr-line>, <country>Ethiopia</country></aff>
<aff id="aff7"><sup>7</sup><institution>Department of Environmental Health, College of Medicine and Health Sciences, Wollo University</institution>, <addr-line>Dessie</addr-line>, <country>Ethiopia</country></aff>
<author-notes>
<fn fn-type="edited-by" id="fn0002">
<p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2268983/overview">Carlos Quispe-Vicu&#x00F1;a</ext-link>, National University of San Marcos, Peru</p>
</fn>
<fn fn-type="edited-by" id="fn0003">
<p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/910367/overview">O. Alexander Miller</ext-link>, Voorhees College, United States</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2394010/overview">Getamesay Aynalem Tesfaye</ext-link>, Jinka University, Ethiopia</p>
</fn>
<corresp id="c001">&#x002A;Correspondence: Sisay Abebe Debela, <email>sisaya@yahoo.com</email>; Chala Daba, <email>chaladaba293@gmail.com</email></corresp>
<fn fn-type="equal" id="fn0001"><p><sup>&#x2020;</sup>These authors have contributed equally to this work</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>09</day>
<month>09</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2025</year>
</pub-date>
<volume>13</volume>
<elocation-id>1513242</elocation-id>
<history>
<date date-type="received">
<day>18</day>
<month>10</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>04</day>
<month>08</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2025 Debela, Tefera, Debela, Gebrehiwot, Bezie, Dadi and Daba.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Debela, Tefera, Debela, Gebrehiwot, Bezie, Dadi and Daba</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Background</title>
<p>Alcohol consumption among University students in Ethiopia is a pressing public health concern. Many existing studies tend to focus on students across all educational levels, including combinations of high school, college, and University students, and determining substance use behaviors, such as Kchat chewing, cigarette smoking, and alcohol consumption. This approach lacks a comprehensive national perspective, particularly with regard to University students. Notably, there is no research available that assesses the extent of alcohol consumption among university students in Ethiopia on a national level. This systematic review and meta-analysis aim to provide comprehensive insights into the prevalence of alcohol use among University students and the factors influencing their drinking behaviors.</p>
</sec>
<sec id="sec2">
<title>Methods</title>
<p>We conducted a comprehensive electronic search across various international databases and libraries, including PubMed/MEDLINE, Hinari, Science direct, African Journals Online and Google Scholar, to identify relevant published reports. The study strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA) guidelines. Analysis was performed using STATA 14 software, employing a random effects model to estimate the pooled effect with a 95% confidence interval (CI). Heterogeneity was visually assessed using forest plots. Additionally, publication bias was evaluated through funnel plots and Egger&#x2019;s and Begg&#x2019;s tests.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>We conducted an analysis of 15 studies involving a total of 10,500 University students in Ethiopia to determine the prevalence of alcohol consumption. Sample sizes across these studies ranged from 188 to 1,239 participants. The pooled prevalence of alcohol consumption was 36.5%. Students who had friend&#x2019;s currently consuming alcohol were found to be twice as likely to engage in alcohol consumption. Additionally, students in Universities who smoke cigarette were also twice as likely to consume alcohol compared to non-smokers. Furthermore, students with family members who drink alcohol were more likely to consume alcohol compared to those from families without this behavior. The study identified <italic>Kchat</italic> chewing habit as an additional factor influencing alcohol consumption among University students in Ethiopia.</p>
</sec>
<sec id="sec4">
<title>Conclusion</title>
<p>Addressing alcohol consumption in these students requires comprehensive interventions that consider these diverse factors to promote responsible drinking and student well-being.</p>
</sec>
</abstract>
<kwd-group>
<kwd>alcohol consumption</kwd>
<kwd>university students</kwd>
<kwd>Ethiopia</kwd>
<kwd>systematic review and meta-analysis</kwd>
<kwd>students</kwd>
</kwd-group>
<counts>
<fig-count count="8"/>
<table-count count="2"/>
<equation-count count="0"/>
<ref-count count="41"/>
<page-count count="13"/>
<word-count count="6656"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Substance Use Disorders and Behavioral Addictions</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<title>Introduction</title>
<p>Alcohol consumption among University students is a global concern due to its potential health, social, and academic implications (<xref ref-type="bibr" rid="ref1">1</xref>). The transition from adolescence to adulthood is marked by the allure of newfound freedom and responsibilities, making this group particularly vulnerable to alcohol-related issues. Worldwide, alcohol consumption among University students follows a diverse trend. Many students experiment with alcohol during their University years, often as a social activity (<xref ref-type="bibr" rid="ref2">2</xref>, <xref ref-type="bibr" rid="ref3">3</xref>). Its implications among University students are far-reaching. It encompasses academic consequences, including impaired cognitive function and decreased performance, as well as various health risks such as addiction, mental health issues, and physical harm (<xref ref-type="bibr" rid="ref3 ref4 ref5">3&#x2013;5</xref>). Moreover, alcohol-related behaviors can impact personal relationships, contribute to risky sexual practices, and pose a burden on University resources and the broader community (<xref ref-type="bibr" rid="ref6 ref7 ref8 ref9">6&#x2013;9</xref>).</p>
<p>According to recent global alcohol consumption statistics, 18.4% of the adult population aged 15&#x202F;years and older engaged in alcohol consumption (<xref ref-type="bibr" rid="ref10">10</xref>). Globally, alcohol consumption was accountable for 1.78 million deaths in 2020, founding it as the leading risk factor for mortality among males aged 15 to 49&#x202F;years (<xref ref-type="bibr" rid="ref6">6</xref>). The Global Burden of Disease (GBD) report in 2020 also estimated that approximately 1.34 billion individuals consumed harmful amounts of alcohol (<xref ref-type="bibr" rid="ref6">6</xref>). The World Health Organization (WHO) has identified more than 300 diseases and adverse conditions that can result from irresponsible alcohol consumption patterns (<xref ref-type="bibr" rid="ref1">1</xref>). The consumption of alcohol at any level is linked to health impairments caused by various diseases, such as liver cirrhosis, breast cancer, tuberculosis, and injuries (<xref ref-type="bibr" rid="ref11 ref12 ref13">11&#x2013;13</xref>). According to Global status report on alcohol and health, the WHO Collaborating Centre for Addiction and Mental Health made an estimation that in 2015, the adult population (aged &#x2265; 15&#x202F;years) consumed approximately 6.43 liters of pure alcohol per capita (<xref ref-type="bibr" rid="ref1">1</xref>).</p>
<p>In the Sub-Saharan African region, alcohol consumption among adolescents is also prevalent (<xref ref-type="bibr" rid="ref4">4</xref>). The pooled prevalence of alcohol consumption among the Sub-Saharan Africans could be as high as 32.77%, while substance abuse among adolescents being 41.6% (<xref ref-type="bibr" rid="ref4">4</xref>). However, the WHO Collaborating Centre for Addiction and Mental Health reported that, Sub-Saharan Africa presented distinctive findings, with the highest prevalence of heavy consumption (78.9%), even though the per capita consumption was relatively low at 4.14 liters (<xref ref-type="bibr" rid="ref1">1</xref>).</p>
<p>Currently, there is a lack of adequate focus on alcohol consumption and its associated health consequences in developing countries. This problem has a particularly pronounced impact on the younger and more economically active segments of the population, who play a pivotal role in propelling a nation&#x2019;s progress. Several observational studies have been conducted among students in developing country like Ethiopia, revealing varying prevalence rates of substance use, particularly alcohol consumption. For instance, in Ghana, the lifetime prevalence of alcohol consumption among University students was 39.5% (<xref ref-type="bibr" rid="ref14">14</xref>), and in Nigeria the level of ever and current use was 43.5 and 31.1%, respectively, (<xref ref-type="bibr" rid="ref9">9</xref>). Similarly, the prevalence of substance use among University students in Ethiopia varied from 16.7 to 72.6% (<xref ref-type="bibr" rid="ref15">15</xref>, <xref ref-type="bibr" rid="ref16">16</xref>). Among college and University students, the lifetime prevalence of alcohol consumption ranges from 13 to 28% (<xref ref-type="bibr" rid="ref16">16</xref>, <xref ref-type="bibr" rid="ref17">17</xref>).</p>
<p>Despite the growing concern surrounding alcohol consumption among University students in Ethiopia, there remains a noticeable research gap. Many existing studies tend to focus on students across all educational levels, including combinations of high school, college, and University students, and determining substance use behaviors, such as <italic>Kchat</italic> chewing, cigarette smoking, and alcohol consumption (<xref ref-type="bibr" rid="ref2">2</xref>, <xref ref-type="bibr" rid="ref16">16</xref>, <xref ref-type="bibr" rid="ref18">18</xref>, <xref ref-type="bibr" rid="ref19">19</xref>). This approach lacks a comprehensive national perspective, particularly with regard to University students. Notably, there is no research available that assesses the extent of alcohol consumption among university students in Ethiopia on a national level. Therefore, this systematic review and meta-analysis provide critical insights into alcohol consumption patterns and associated factors among university students in Ethiopia. Addressing these research gaps is crucial for developing evidence-based strategies that account for the complexity of alcohol consumption among Ethiopian university students and ultimately improving their well-being.</p>
</sec>
<sec sec-type="methods" id="sec6">
<title>Methodology</title>
<sec id="sec7">
<title>Study registration</title>
<p>The systematic review and meta-analysis followed the Joanna Briggs Institute (JBI) methodology for systematic reviews and Meta-analysis (<xref ref-type="bibr" rid="ref20">20</xref>). The protocol has been registered in PROSPERO (CRD42023444392).</p>
</sec>
<sec id="sec8">
<title>Search strategy</title>
<p>All potentially relevant articles, gray literature, and government reports were meticulously searched to conduct this study. International databases and libraries, such as PubMed/MEDLINE, Google Scholar, Hinari, African Journals Online and Science direct, were included to search relevant studies. We retrieved gray literature using Google and Google Scholar searches. We also reviewed reference lists of identified studies in order to find and retrieve additional articles. Unpublished studies were retrieved from the official websites of international and local organizations and universities. An extensive search was done from the databases using the following keywords: &#x201C;prevalence,&#x201D; &#x201C;proportion,&#x201D; &#x201C;magnitude,&#x201D; &#x201C;alcohol,&#x201D; &#x201C;alcohol consumption,&#x201D; &#x201C;alcohol drinking,&#x201D; &#x201C;alcohol user,&#x201D; &#x201C;substance user,&#x201D; &#x201C;factors,&#x201D; &#x201C;determinants,&#x201D; &#x201C;predictors,&#x201D; &#x201C;factors associated,&#x201D; &#x201C;associated factors,&#x201D; &#x201C;risk factor,&#x201D; &#x201C;university student,&#x201D; &#x201C;students,&#x201D; and &#x201C;Ethiopia&#x201D; without restring the study period. We undertook advanced search by combining the search terms using Boolean operators (<xref ref-type="supplementary-material" rid="SM1">Supplementary 1</xref>). The search for all articles was conducted from September 1st to 15th October, 2024.</p>
</sec>
<sec id="sec9">
<title>Study selection and eligibility criteria</title>
<p>The review included Ethiopian studies that reported the prevalence of alcohol consumption, as well as articles published in scientific journals and gray literature. Only study reports written in English language and full-text articles were considered. Furthermore, the review looked at all observational study (cross-sectional). Articles that could not be accessed for full text after at least three emails to the primary study&#x2019;s principal investigators were excluded. Two independent reviewers (SAD and CD) screened the records for inclusion. Each reviewer carried out the screening evaluation independently. Disagreements among reviewers were discussed with the review team members until a consensus is reached.</p>
</sec>
<sec id="sec10">
<title>Inclusion criteria</title>
<p>Population: This systematic review and meta-analysis included studies conducted among University students in Ethiopia.</p>
<p>Exposure: An individual student who experienced alcohol consumption.</p>
<p>Comparison: Individual students who drunk and do not drink alcohol at University.</p>
<p>Outcome: This study estimated the pooled magnitude of alcohol consumption and its association among University students. The magnitude was computed as the proportion of the number of individuals who consume alcohol to the total number of participants and multiplied by 100.</p>
<p>Study setting: Ethiopia.</p>
<p>Study design: observational study (cross-sectional, cohort and case&#x2013;control).</p>
<p>Publication: Both published and unpublished studies were included.</p>
</sec>
<sec id="sec11">
<title>Exclusion criteria</title>
<p>Qualitative studies, unretrievable studies, editorial letters, studies with poor methodological quality, and studies that did not report the outcome of interest were excluded from the meta-analysis.</p>
</sec>
<sec id="sec12">
<title>Outcome assessment</title>
<p>The primary outcome of this meta-analysis was to estimate the overall prevalence of alcohol consumption among university students in Ethiopia. This was calculated by dividing the number of alcohol users by the total sample size and multiplying by 100. Additionally, the study aimed to identify factors associated with alcohol consumption, expressed as a log odds ratio.</p>
</sec>
<sec id="sec13">
<title>Quality assessment and data extraction</title>
<p>Duplicated records were removed using reference management software (EndNote X7). The titles and abstracts were reviewed by two reviewers (SAD and CD) and records that did not fulfill our criteria, such as guidelines, reviews, position papers, and records without an abstract (if title is the only available information), were excluded. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was used to assess papers objectively (<xref ref-type="bibr" rid="ref21">21</xref>). When there is disagreement between reviewers, it was discussed with the other members of the review team until an agreement is reached. A third reviewer was invited to resolve the disagreements between the two independent reviewers (MG). A standardized data extraction format was used by three independent reviewers to extract the data (SAD, CD and MG). The data extraction spread sheet included primary author name, year of publication, study setting (region), study design, sample size, response rate, alcohol consumption (Yes/No), and quality of the paper result. PRISMA flow diagram was used to show the review process of the studies (<xref ref-type="fig" rid="fig1">Figure 1</xref>).</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>PRISMA flow diagram of the included studies for the systematic review and meta-analysis of alcohol consumption and its associated factors among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g001.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Flowchart illustrating the identification and screening process for studies. From a total of 2,564 records in databases, 479 were screened after removing 918 duplicates and 1,167 based on title. 18 reports were retrieved, and 5 were excluded for not reporting desired outcomes or failing quality assessment. From other methods, 3 reports were identified; 1 was excluded. Ultimately, 15 studies were included in the meta-analysis.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec14">
<title>Assessing certainty in the findings</title>
<p>The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach for assessing the quality of evidence was used to create the summary of findings. The outcomes reported in the summary of findings were the pooled prevalence of alcohol consumption among university students and its association with different factors. The quality of the evidence was assessed independently based on the five domains established by the GRADE guidelines: risk of bias, inconsistency, indirectness, imprecision, and publication bias.</p>
</sec>
<sec id="sec15">
<title>Data analysis and synthesis</title>
<p>Using the &#x2018;generate&#x2019; command in STATA 14, from the original research, odds ratios (OR) and standard errors were created for all the included studies. The <italic>p</italic>-values of the Cochrane Q-test and I<sup>2</sup>-test statistics were used to assess the heterogeneity among studies. The publication bias was assessed visually using a funnel plot. Asymmetry in the funnel plot indicates the possibility of publication bias. Moreover, Egger&#x2019;s test was used to determine if there has been a significant publication bias, with a p-value of less than 0.10 indicating the presence of significant publication bias (<xref ref-type="bibr" rid="ref22">22</xref>). Because Egger&#x2019;s test is more specific than Begg&#x2019;s test, it was used to assess publication bias. We used the log odds ratio to determine the association between different factors and their alcohol consumption. Furthermore, sensitivity analysis using a random effects model was performed to assess the effect of a single study on the pooled magnitude estimates (<xref ref-type="bibr" rid="ref23">23</xref>). Sub-group analysis was used to lower the random variations between the primary study&#x2019;s inter-group estimates, and the analysis was done based on region, year of publication and sampling technique.</p>
</sec>
</sec>
<sec sec-type="results" id="sec16">
<title>Results</title>
<sec id="sec17">
<title>Identification and selection of studies</title>
<p>Upon completing the electronic database search, 2,564 articles were identified. Using the Endnote reference manager, 461 duplicate studies were excluded using title and abstract. Moreover, 5 studies were excluded based on the quality assessment and outcomes of the interest. Finally, 15 studies were eligible for this meta-systematic review and analysis. The process of selecting these studies is visually described in a PRISMA flow diagram (<xref ref-type="fig" rid="fig1">Figure 1</xref>).</p>
</sec>
<sec id="sec18">
<title>Characteristics of the included studies</title>
<p>We included 15 studies in meta-analysis to assess the prevalence of alcohol consumption among university students in Ethiopia. These studies involved a total of 10,500 individuals, with sample sizes ranging from 188 to 1,239 participants across the various studies. Notably, the study findings indicated that the highest lifetime prevalence of alcohol consumption was reported in Dire-Dawa University (<xref ref-type="bibr" rid="ref24">24</xref>), at 60%. Conversely, the lowest lifetime prevalence, at 25.1%, was documented in a study conducted at Mekelle University (<xref ref-type="table" rid="tab1">Table 1</xref>) (<xref ref-type="bibr" rid="ref25">25</xref>). The findings concerning alcohol consumption varied among the included studies and did not provide conclusive results.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Characteristics of studies included in the systematic review and meta-analysis of alcohol consumption and associated factors among university students in Ethiopia.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Authors</th>
<th align="center" valign="top">Year of publication</th>
<th align="left" valign="top">Region</th>
<th align="left" valign="top">Study design</th>
<th align="left" valign="top">Sampling technique</th>
<th align="center" valign="top">Sample size</th>
<th align="center" valign="top">Response rate</th>
<th align="center" valign="top">Lifetime prevalence</th>
<th align="center" valign="top">Current prevalence</th>
<th align="center" valign="top">Quality scores (8)</th>
<th align="center" valign="top">Reference</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Chekole</td>
<td align="center" valign="top">2020</td>
<td align="left" valign="top">SNNPR</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SytRS</td>
<td align="center" valign="top">876</td>
<td align="center" valign="top">91.70%</td>
<td align="center" valign="top">41.8</td>
<td align="center" valign="top">24.4</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref31">31</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Deressa and Azazh</td>
<td align="center" valign="top">2011</td>
<td align="left" valign="top">AA</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">Not available</td>
<td align="center" valign="top">632</td>
<td align="center" valign="top">98.40%</td>
<td align="center" valign="top">31.4</td>
<td align="center" valign="top">4.5</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref32">32</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Gebreslassie et al.</td>
<td align="center" valign="top">2013</td>
<td align="left" valign="top">Tigray</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">MSST</td>
<td align="center" valign="top">764</td>
<td align="center" valign="top">98.70%</td>
<td align="center" valign="top">34.5</td>
<td align="center" valign="top">9.3</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref7">7</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Birhanu</td>
<td align="center" valign="top">2016</td>
<td align="left" valign="top">Oromia</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SRS</td>
<td align="center" valign="top">440</td>
<td align="center" valign="top">97%</td>
<td align="center" valign="top">50.7</td>
<td align="center" valign="top">26.1</td>
<td align="center" valign="top">8</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref8">8</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Esmael</td>
<td align="center" valign="top">2014</td>
<td align="left" valign="top">Oromia</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">MSST</td>
<td align="center" valign="top">845</td>
<td align="center" valign="top">96.6%</td>
<td align="center" valign="top">35</td>
<td align="center" valign="top">-</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref33">33</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Gebremariam et al.</td>
<td align="center" valign="top">2018</td>
<td align="left" valign="top">Amhara</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SS</td>
<td align="center" valign="top">695</td>
<td align="center" valign="top">89.00%</td>
<td align="center" valign="top">36.3</td>
<td align="center" valign="top">17</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref15">15</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Aklog et al.</td>
<td align="center" valign="top">2013</td>
<td align="left" valign="top">Amhara</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SRS</td>
<td align="center" valign="top">423</td>
<td align="center" valign="top">97.00%</td>
<td align="center" valign="top">-</td>
<td align="center" valign="top">13.4</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref34">34</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Tesso Kumburi et al.</td>
<td align="center" valign="top">2017</td>
<td align="left" valign="top">DD</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SytRS</td>
<td align="center" valign="top">1,239</td>
<td align="center" valign="top">73.85%</td>
<td align="center" valign="top">60</td>
<td align="center" valign="top">45</td>
<td align="center" valign="top">8</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref24">24</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Tesfaye et al.</td>
<td align="center" valign="top">2014</td>
<td align="left" valign="top">Oromia</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">MSST</td>
<td align="center" valign="top">1,040</td>
<td align="center" valign="top">98.30%</td>
<td align="center" valign="top">50.2</td>
<td align="center" valign="top">20</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref35">35</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Kassa et al.</td>
<td align="center" valign="top">2016</td>
<td align="left" valign="top">Sidama</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">MSST</td>
<td align="center" valign="top">590</td>
<td align="center" valign="top">94.50%</td>
<td align="center" valign="top">48.7</td>
<td align="center" valign="top">29.5</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref36">36</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Shiferaw</td>
<td align="center" valign="top">2017</td>
<td align="left" valign="top">Somale</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">MSST</td>
<td align="center" valign="top">648</td>
<td align="center" valign="top">92.60%</td>
<td align="center" valign="top">27.3</td>
<td align="center" valign="top">18.3</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref37">37</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Derese et al.</td>
<td align="center" valign="top">2014</td>
<td align="left" valign="top">Oromia</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SRS</td>
<td align="center" valign="top">764</td>
<td align="center" valign="top">94.90%</td>
<td align="center" valign="top">41.7</td>
<td align="center" valign="top">17.5</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref38">38</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Desta et al.</td>
<td align="center" valign="top">2018</td>
<td align="left" valign="top">Oromia</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">Census</td>
<td align="center" valign="top">188</td>
<td align="center" valign="top">98.90%</td>
<td align="center" valign="top">26.34</td>
<td align="center" valign="top">25.3</td>
<td align="center" valign="top">8</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref39">39</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Kumesa et al.</td>
<td align="center" valign="top">2015</td>
<td align="left" valign="top">Ethiopia</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SRS</td>
<td align="center" valign="top">355</td>
<td align="center" valign="top">97.70%</td>
<td align="center" valign="top">40.2</td>
<td align="center" valign="top">35.6</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref40">40</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Hagos et al.</td>
<td align="center" valign="top">2016</td>
<td align="left" valign="top">Tigray</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">SRS</td>
<td align="center" valign="top">271</td>
<td align="center" valign="top">100.00%</td>
<td align="center" valign="top">25.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref25">25</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Adere et al.</td>
<td align="center" valign="top">2017</td>
<td align="left" valign="top">Amhara</td>
<td align="left" valign="top">Cross-sectional</td>
<td align="left" valign="top">MSST</td>
<td align="center" valign="top">730</td>
<td align="center" valign="top">89.70%</td>
<td align="center" valign="top">33.1</td>
<td align="center" valign="top">27.9</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">(<xref ref-type="bibr" rid="ref41">41</xref>)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>MSST, multi-stage sampling technique; SS, stratified sampling; SytRS, systematic random sampling technique; SRS, simple random sampling technique; DD, Dire Dawa; AA, Addis Ababa.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec19">
<title>Prevalence of alcohol consumption</title>
<p>The analysis of 15 studies revealed that the pooled prevalence of lifetime alcohol consumption among university students was 36.55% (95% CI: 32.30&#x2013;40.80). A significant degree of heterogeneity (<italic>I</italic><sup>2</sup> =&#x202F;95%; <italic>p</italic>&#x202F;=&#x202F;0.00) was observed among these studies (<xref ref-type="fig" rid="fig2">Figure 2</xref>). Thus, we applied a random effects model to estimate the overall prevalence of alcohol consumption among university students. Furthermore, the pooled prevalence of current alcohol consumption among university students was 19.49% (95% CI: 14.50&#x2013;24.48) (<xref ref-type="fig" rid="fig3">Figure 3</xref>).</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>Forest plot of the pooled prevalence of lifetime alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g002.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Forest plot showing a meta-analysis of various studies listed by author and year. The plot includes effect size estimates with 95% confidence intervals and percentage weights for each study. The diamond at the bottom represents the overall combined effect size: 36.55 (32.30, 40.80). Weights are derived from a random effects analysis with I-squared at 95.1% and p-value of 0.000.</alt-text>
</graphic>
</fig>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>Forest plot of the pooled prevalence of current alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g003.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Forest plot depicting the effect sizes and confidence intervals for various studies. Each study is represented by a point estimate with horizontal lines indicating the confidence intervals. The diamond at the bottom represents the overall effect size. Weights from random effect analysis are shown as percentages.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec20">
<title>Publication bias</title>
<p>To assess publication bias, we employed both funnel plots and statistical tests, including the Egger and Begg&#x2019;s tests, with a significance level set at 5%. Upon visual check, the funnel plot showed symmetrical distribution, suggesting no apparent signs of publication bias. Additionally, the Egger test statistics did not indicate the presence of statistically significant publication bias (<italic>p</italic>&#x202F;=&#x202F;0. 307). Furthermore, there is no substantial presence of small-study effects based on the test results (<xref ref-type="fig" rid="fig4">Figure 4</xref>).</p>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption>
<p>Funnel plot of the pooled prevalence of lifetime alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g004.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Funnel plot showing data points with pseudo 95% confidence limits. The x-axis represents "logpre" and the y-axis represents "s.e. of logpre". Data points are concentrated near the central vertical line, within the dashed lines forming a funnel shape.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec21">
<title>Sensitivity analysis</title>
<p>To evaluate the potential impact of individual studies on the overall meta-analysis estimate, we performed a sensitivity analysis using a random effects model. This analysis was conducted to discern whether any specific study significantly influenced the overall pooled estimate of alcohol consumption. The outcomes of this sensitivity analysis revealed that none of the individual studies had a substantial effect on the overall pooled prevalence (<xref ref-type="fig" rid="fig5">Figure 5</xref>).</p>
<fig position="float" id="fig5">
<label>Figure 5</label>
<caption>
<p>Sensitivity analysis for single study influence on overall pooled estimated of tobacco smoking among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g005.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Forest plot showing meta-analysis estimates with studies omitted, labeled on the left. Each line represents a study&#x2019;s confidence interval with an estimate marked by a circle. The x-axis ranges from 31.34 to 41.64.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec22">
<title>Subgroup analysis by year of publication</title>
<p>The objective of this analysis was to compare the pooled prevalence of lifetime alcohol consumption among university students in Ethiopia between studies published prior to and after 2015. The findings of the subgroup analysis demonstrated that the pooled prevalence of lifetime alcohol consumption in studies conducted before 2015 was 37.43% (95% CI: 30.66&#x2013;44.120), slightly exceeding the prevalence observed in studies conducted during and after 2015 was 36.09% (95% CI: 30.33&#x2013;41.84) (<xref ref-type="fig" rid="fig6">Figure 6</xref>).</p>
<fig position="float" id="fig6">
<label>Figure 6</label>
<caption>
<p>Subgroup analysis by year publication of the pooled prevalence of lifetime alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g006.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Forest plot showing the effects and confidence intervals for studies categorized by year. Studies from 2015 and after include authors like Chekole and Birhanu A, displaying various effect values and weights. Before 2015, authors include Deressa et al and Gebreslassie et al, with different effect values and weights. Subgroup analysis shows significant heterogeneity. Overall effect size is 36.55 with 95% CI.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec23">
<title>Subgroup analysis by region</title>
<p>Furthermore, a subgroup analysis was carried out based on the region to reduce the possibility of random variations across studies and to assess the prevalence of lifetime alcohol consumption in various regions. The highest pooled prevalence of alcohol consumption was observed in the Oromia region at 39.8% (95% CI: 32.8&#x2013;46.8), were as the lowest were observed in Tigray at 29.8% (95% CI: 20.9&#x2013;38.7) (<xref ref-type="fig" rid="fig7">Figure 7</xref>). The results of this analysis indicated that there were significant differences in the pooled prevalence of alcohol consumption among university students across different region. These findings emphasize that there is significant variation in alcohol consumption among university students from different region of Ethiopia (<xref ref-type="fig" rid="fig7">Figure 7</xref>).</p>
<fig position="float" id="fig7">
<label>Figure 7</label>
<caption>
<p>Subgroup analysis by study countries of the pooled prevalence of lifetime alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g007.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Forest plot showing effect sizes and confidence intervals for studies grouped by regions: Other, Tigray, Oromia, and Amhara. Weights range from 6.41% to 6.87% per study. Heterogeneity between groups is p = 0.055. Overall effect size is 36.55 with a confidence interval of 32.30 to 40.80 at 100% weight. Subgroup analyses show high heterogeneity except for Amhara.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec24">
<title>Subgroup analysis by study technique</title>
<p>The findings from the subgroup analysis unveiled that the combined prevalence of lifetime alcohol consumption among university students in Ethiopia was 36% (95% CI: 29.21&#x2013;42.81) for studies employing a multi-stage study technique. This figure was slightly lower than the pooled prevalence observed in studies using other sampling technique (<xref ref-type="table" rid="tab1">Table 1</xref>) which stood at 37% (95% CI: 31.5&#x2013;42.5) as depicted in <xref ref-type="fig" rid="fig8">Figure 8</xref>.</p>
<fig position="float" id="fig8">
<label>Figure 8</label>
<caption>
<p>Subgroup analysis by sampling technique of the pooled prevalence of lifetime alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<graphic xlink:href="fpubh-13-1513242-g008.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Forest plot showing effect sizes with confidence intervals from studies using two sampling techniques: "Others" and "Multi-stage." Each study's effect size, confidence interval, and weight are listed. Subgroup analyses show significant heterogeneity, with diamond markers indicating overall effect sizes.</alt-text>
</graphic>
</fig>
</sec>
<sec id="sec25">
<title>Factors associated with alcohol consumption</title>
<p>Among the 15 studies that fulfilled the inclusion criteria, five studies were considered for assessing the association between alcohol consumption and having a friend currently drinking alcohol. Students who had friends currently drinking alcohol were 1.75 times likely to engage in alcohol consumption than those who did not have such friends (OR&#x202F;=&#x202F;1.75, CI: 95%, 1.29&#x2013;2.21). Students in universities who smoke cigarette were also twice as likely to consume alcohol compared to non-smokers in four studies (OR&#x202F;=&#x202F;1.92, CI: 95%, 1.06&#x2013;2.78). Six studies were considered for assessing the association between alcohol consumption, and having a family currently drinking alcohol and chewing <italic>Kchat</italic>. Additionally, students who had family members who drank alcohol were 1.14 times more likely to consume alcohol compared to those from families without these behaviors (OR&#x202F;=&#x202F;1.14, CI: 95% 1.1&#x2013;1.7). Furthermore, the Chewing of <italic>Kchat</italic> was identified in six studies as additional factors influencing alcohol consumption. Students in universities who consume <italic>Kchat</italic> were 1.7 times likely to consume alcohol compared to non-consumer (OR&#x202F;=&#x202F;1.7, CI: 95%, 1.23&#x2013;2.16) (<xref ref-type="table" rid="tab2">Table 2</xref>).</p>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>The pooled effect size of factors associated with alcohol consumption among university students in Ethiopia, 2024.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Variables</th>
<th align="center" valign="top" rowspan="2">Number of study included</th>
<th align="center" valign="top" rowspan="2">Odd ratio (95% CI)</th>
<th align="center" valign="top" colspan="2">Heterogeneity</th>
</tr>
<tr>
<th align="center" valign="top">
<italic>I</italic>
<sup>2</sup>
</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1.17 (0.96&#x2013;1.38)</td>
<td align="center" valign="top">66.8%</td>
<td align="center" valign="top">0.002</td>
</tr>
<tr>
<td align="left" valign="top">Friend currently drinking alcohol</td>
<td align="center" valign="top">5</td>
<td align="center" valign="top">1.75 (1.29&#x2013;2.21)&#x002A;</td>
<td align="center" valign="top">71.1%</td>
<td align="center" valign="top">0.008</td>
</tr>
<tr>
<td align="left" valign="top">Cigarette smoking</td>
<td align="center" valign="top">4</td>
<td align="center" valign="top">1.92 (1.06&#x2013;2.78)&#x002A;</td>
<td align="center" valign="top">37.1%</td>
<td align="center" valign="top">0.189</td>
</tr>
<tr>
<td align="left" valign="top">Urban residence</td>
<td align="center" valign="top">2</td>
<td align="center" valign="top">1.29 (0.82&#x2013;1.76)</td>
<td align="center" valign="top">0.0%</td>
<td align="center" valign="top">0.543</td>
</tr>
<tr>
<td align="left" valign="top">Peer pressure</td>
<td align="center" valign="top">2</td>
<td align="center" valign="top">1.36 (0.73&#x2013;1.98)</td>
<td align="center" valign="top">0.0%</td>
<td align="center" valign="top">0.33</td>
</tr>
<tr>
<td align="left" valign="top">Illegal drug use</td>
<td align="center" valign="top">2</td>
<td align="center" valign="top">1.59 (&#x2212;1.60&#x2013;4.80)</td>
<td align="center" valign="top">10.4%</td>
<td align="center" valign="top">0.291</td>
</tr>
<tr>
<td align="left" valign="top">Family&#x2019;s drinks alcohol</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">1.14 (1.10&#x2013;1.72)&#x002A;</td>
<td align="center" valign="top">66.4%</td>
<td align="center" valign="top">0.011</td>
</tr>
<tr>
<td align="left" valign="top"><italic>Kchat</italic> use</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">1.70 (1.23&#x2013;2.16)&#x002A;</td>
<td align="center" valign="top">43.5%</td>
<td align="center" valign="top">0.115</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><sup>&#x002A;</sup>Significant at <italic>p</italic>-value &#x003C;0.05.</p>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec sec-type="discussion" id="sec26">
<title>Discussion</title>
<p>Numerous studies have explored the potential link between alcohol use and its associations with various factors. However, the results of these studies have often been conflicting and lacking in consensus. The findings from our analysis of 15 studies encompassing 10,500 university students in Ethiopia shed light on the prevalence and various factors associated with alcohol consumption. Notably, the pooled prevalence of lifetime alcohol consumption was 36.5%, underlining the significance of this issue among university students in the country. The substantial impact of alcohol consumption identified in the current systematic review and analysis exceeds the figures reported in global alcohol consumption statistics (18.4%) and the global status report on alcohol and health in Sub-Saharan Africa (32.7%), systematic review and meta-analysis on alcohol consumption among all students (26.19%), and a report from photoactive substance use among University Students (32.28%) (<xref ref-type="bibr" rid="ref1">1</xref>, <xref ref-type="bibr" rid="ref2">2</xref>, <xref ref-type="bibr" rid="ref10">10</xref>, <xref ref-type="bibr" rid="ref16">16</xref>). Our findings show the urgent need for targeted interventions and preventive measures to address the high prevalence of alcohol consumption among university students in Ethiopia. This is a pressing public health concern that demands focused attention and strategies to the specific context of university life in the country. Nonetheless, the outcome of this systematic review reveals a lower prevalence of alcohol consumption compared to other sources of evidence in Ethiopia. For instance, epidemiological data on alcohol consumption in Ethiopia indicates a rate of 44.16% (<xref ref-type="bibr" rid="ref26">26</xref>). Likewise, a report from prevalence of life time substance use specifically alcohol consumption among students in Ethiopia was reported to be 46.2% (<xref ref-type="bibr" rid="ref19">19</xref>). The lower prevalence rate in the current systematic review compared to other studies may be due to a combination of factors related to sampling, timing, and participant characteristics.</p>
<p>This comprehensive analysis unveiled a significant association between alcohol consumption and several factors, including peer networks, tobacco use, <italic>Kchat</italic> chewing, and family influences. Peer influence emerged as a potent factor, as students with friends currently consuming alcohol were 1.75 as likely to engage in alcohol consumption. This outcome is consistent with the findings of a systematic review and meta-analysis on psychoactive substance abuse and alcohol consumption among both high school and University students, and adolescent and Youth in Ethiopia (<xref ref-type="bibr" rid="ref16">16</xref>, <xref ref-type="bibr" rid="ref27">27</xref>). Peer influence significantly impacts alcohol consumption, driven by factors such as social norms, direct peer pressure, modeling behavior, social events, and availability of alcohol. Peer networks and social dynamics play pivotal roles in shaping students&#x2019; drinking habits, necessitating peer-led initiatives and awareness programs (<xref ref-type="bibr" rid="ref26">26</xref>). This influence can be reinforced by peer identity, positive reinforcement, and social support. The desire to conform and meet peer expectations can lead individuals to engage in drinking behaviors within their social circles. So, it is essential for designing interventions that promote responsible drinking and mitigate negative consequences associated with excessive alcohol use among peers.</p>
<p>The link between tobacco use and alcohol consumption was another significant finding, with students who smoked cigarettes having twice the likelihood of alcohol consumption. This finding is consistent with the findings of a systematic review and meta-analysis for substance use among adolescents in sub-Saharan Africa (<xref ref-type="bibr" rid="ref4">4</xref>). This finding is also aligns with systematic review and meta-analysis conducted in Ethiopia that have documented significant associations between smoking cigarette and alcohol consumption (<xref ref-type="bibr" rid="ref27 ref28 ref29">27&#x2013;29</xref>). Smoking cigarettes can significantly influence the alcohol consumption of University students (<xref ref-type="bibr" rid="ref29">29</xref>). The co-occurrence of these behaviors is common due to shared addictive qualities. Nicotine in cigarettes can enhance the pleasurable effects of alcohol, leading to increased alcohol consumption (<xref ref-type="bibr" rid="ref29">29</xref>). Additionally, students who smoke may find themselves in social contexts where both smoking and drinking are prevalent, further reinforcing this association (<xref ref-type="bibr" rid="ref28">28</xref>, <xref ref-type="bibr" rid="ref29">29</xref>). It is important for addressing substance use and promoting healthier behaviors among university students. This suggests that substance use behaviors often co-occur and underscores the importance of addressing multiple substances in prevention efforts.</p>
<p>Family environment was identified as the determinant factors of alcohol consumption. Students from families with a history of alcohol consumption are 1.14 times more likely to consume alcohol compared to their counterparts. Family members who drink alcohol can significantly impact students&#x2019; alcohol consumption (<xref ref-type="bibr" rid="ref19">19</xref>, <xref ref-type="bibr" rid="ref26">26</xref>). Younger age children, such as students might be tempted with the presence of alcohol at household level. Exposure to these behaviors in the family environment may normalize and increase the likelihood of alcohol use. Additionally, family dynamics and communication patterns play a role in shaping attitudes and behaviors toward alcohol use. Recognizing these familial influences is vital for targeted interventions addressing alcohol consumption among students. Family-based interventions and support for creating alcohol-free home environments could prove beneficial.</p>
<p>Moreover, the Chewing <italic>Kchat</italic> was identified as additional factor affecting alcohol consumption. This finding is also aligns with systematic review and meta-analysis conducted in Ethiopia that have documented significant associations between chewing <italic>Kchat</italic> and alcohol consumption (<xref ref-type="bibr" rid="ref27">27</xref>). Furthermore, the results of the our systematic review align with the findings from a systematic review and meta-analysis on <italic>Kchat</italic> chewing among University students in Ethiopia, indicating that chewing <italic>Kchat</italic> can significantly influence students&#x2019; alcohol consumption (<xref ref-type="bibr" rid="ref28">28</xref>). Social settings where chewing <italic>Kchat</italic> occurs can normalize alcohol consumption (<xref ref-type="bibr" rid="ref30">30</xref>). Students may also use alcohol to counteract the effects of <italic>Kchat</italic>. These findings highlight the complexity of substance use behaviors among university students, necessitating a comprehensive approach to address multiple risk factors simultaneously.</p>
<sec id="sec27">
<title>Strengths and limitations of the study</title>
<p>One of the strengths of the current meta-analysis is that it follows the updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. However, a limitation of this meta-analysis is that it did not establish causality between the independent and dependent variables, as most of the included studies utilized cross-sectional designs.</p>
</sec>
</sec>
<sec sec-type="conclusions" id="sec28">
<title>Conclusion</title>
<p>This systematic review and meta-analysis provided insights into alcohol consumption among university students in Ethiopia. The pooled prevalence of alcohol consumption was found to be 36.5%. The study underscores the multifaceted nature of alcohol consumption among university students; peer influence, smoking habits, family environment, and other substance use behaviors all playing significant roles in shaping alcohol consumption patterns. These results emphasize the importance of considering peer networks, tobacco use, and family influences when addressing alcohol consumption among university students. Additionally, the study highlights the need for comprehensive interventions that take into account these multifaceted factors to promote responsible alcohol use among this population. Future research and targeted programs should address these complex factors to develop effective strategies for reducing risky alcohol behaviors among university students.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="sec29">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/<xref ref-type="sec" rid="sec35">Supplementary material</xref>, further inquiries can be directed to the corresponding authors.</p>
</sec>
<sec sec-type="author-contributions" id="sec30">
<title>Author contributions</title>
<p>SD: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. YT: Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Visualization, Writing &#x2013; review &#x0026; editing. EAD: Funding acquisition, Methodology, Software, Validation, Visualization, Writing &#x2013; review &#x0026; editing. MG: Investigation, Project administration, Software, Supervision, Validation, Visualization, Writing &#x2013; review &#x0026; editing. AB: Methodology, Resources, Software, Supervision, Writing &#x2013; review &#x0026; editing. EBD: Investigation, Methodology, Resources, Software, Supervision, Writing &#x2013; review &#x0026; editing. CD: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec sec-type="funding-information" id="sec31">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research and/or publication of this article.</p>
</sec>
<sec sec-type="COI-statement" id="sec32">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="sec33">
<title>Generative AI statement</title>
<p>The authors declare that no Gen AI was used in the creation of this manuscript.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p>
</sec>
<sec sec-type="disclaimer" id="sec34">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec sec-type="supplementary-material" id="sec35">
<title>Supplementary material</title>
<p>The Supplementary material for this article can be found online at: <ext-link xlink:href="https://www.frontiersin.org/articles/10.3389/fpubh.2025.1513242/full#supplementary-material" ext-link-type="uri">https://www.frontiersin.org/articles/10.3389/fpubh.2025.1513242/full#supplementary-material</ext-link></p>
<supplementary-material xlink:href="Table_1.docx" id="SM1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" xmlns:xlink="http://www.w3.org/1999/xlink"/>
<supplementary-material xlink:href="Table_2.docx" id="SM2" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" xmlns:xlink="http://www.w3.org/1999/xlink"/>
</sec>
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