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<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
<issn pub-type="epub">2296-2565</issn>
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<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-id pub-id-type="doi">10.3389/fpubh.2025.1399336</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>COVID-19 vaccine information disorder in Chile: a quantitative analysis of fact-checked articles</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" equal-contrib="yes">
<name><surname>Cruz</surname> <given-names>Alexis V.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="author-notes" rid="fn0001"><sup>&#x2020;</sup></xref>
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<contrib contrib-type="author" equal-contrib="yes">
<name><surname>Schulz</surname> <given-names>Vicente</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="author-notes" rid="fn0001"><sup>&#x2020;</sup></xref>
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<contrib contrib-type="author">
<name><surname>Arriagada</surname> <given-names>Eduardo</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
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<contrib contrib-type="author">
<name><surname>Montero-Liberona</surname> <given-names>Claudia A.</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
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<contrib contrib-type="author" corresp="yes">
<name><surname>Kalergis</surname> <given-names>Alexis M.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
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<aff id="aff1"><sup>1</sup><institution>Millennium Institute on Immunology and Immunotherapy</institution>, <addr-line>Santiago</addr-line>, <country>Chile</country></aff>
<aff id="aff2"><sup>2</sup><institution>Facultad de Comunicaciones, Pontificia Universidad Cat&#x00F3;lica de Chile</institution>, <addr-line>Santiago</addr-line>, <country>Chile</country></aff>
<aff id="aff3"><sup>3</sup><institution>Facultad de Ciencias Biol&#x00F3;gicas, Pontificia Universidad Cat&#x00F3;lica de Chile</institution>, <addr-line>Santiago</addr-line>, <country>Chile</country></aff>
<aff id="aff4"><sup>4</sup><institution>Departamento de Endocrinolog&#x00ED;a, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Cat&#x00F3;lica de Chile</institution>, <addr-line>Santiago</addr-line>, <country>Chile</country></aff>
<author-notes>
<fn fn-type="edited-by" id="fn0002"><p>Edited by: Reza Lashgari, Shahid Beheshti University, Iran</p></fn>
<fn fn-type="edited-by" id="fn0003"><p>Reviewed by: Anthony Afum-Adjei Awuah, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Ghana</p><p>Ernesto Isaac Montenegro Renoiner, Epidemiologia Brasil, Brazil</p></fn>
<corresp id="c001">&#x002A;Correspondence: Alexis M. Kalergis, <email>akalergis@uc.cl</email></corresp>
<fn fn-type="equal" id="fn0001"><p><sup>&#x2020;</sup>These authors have contributed equally to this work</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>09</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2025</year>
</pub-date>
<volume>13</volume>
<elocation-id>1399336</elocation-id>
<history>
<date date-type="received">
<day>18</day>
<month>07</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>09</day>
<month>04</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2025 Cruz, Schulz, Arriagada, Montero-Liberona and Kalergis.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Cruz, Schulz, Arriagada, Montero-Liberona and Kalergis</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Introduction</title>
<p>Previous studies have analyzed information disorder during the COVID-19 pandemic, focusing on common characteristics such as content formats, recurring themes, and information dissemination networks. However, in the Latin American region, there is still a gap in studying the specific characteristics of this phenomenon during the COVID-19 vaccination process, as in the Chilean case. Therefore, this study aims to identify the main characteristics of information disorder circulating in Chile during the COVID-19 vaccination process, considering key topics, actors, and media platforms involved.</p>
</sec>
<sec id="sec2">
<title>Methods</title>
<p>We conducted a quantitative content analysis of a dataset of 140 fact-checking articles related to COVID-19 vaccination, sourced from MalaEspina and FastCheck, from March 2020 to December 2022.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>We identified the primary characteristics of information disorders that circulated in Chile concerning the COVID-19 vaccination process. Our main findings indicated that information disorder focused on disinformation intended to cause harm through deception. The primary format used was visual and distributed across various platforms.</p>
</sec>
<sec id="sec4">
<title>Discussion and conclusion</title>
<p>We conclude that studying information disorder in specific topics, such as vaccination, is important to understand the phenomenon better and develop strategies to mitigate its impact on society.</p>
</sec>
</abstract>
<kwd-group>
<kwd>information disorder</kwd>
<kwd>vaccination process</kwd>
<kwd>COVID-19</kwd>
<kwd>fact-checking</kwd>
<kwd>vaccines</kwd>
<kwd>vaccine hesitancy</kwd>
</kwd-group>
<counts>
<fig-count count="5"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="80"/>
<page-count count="10"/>
<word-count count="7923"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Public Health Education and Promotion</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<label>1</label>
<title>Introduction</title>
<p>The circulation and propagation of inaccurate information have been a concern in worldwide regions and media outlets (<xref ref-type="bibr" rid="ref1">1</xref>), especially during the COVID-19 vaccination process (<xref ref-type="bibr" rid="ref2 ref3 ref4 ref5 ref6">2&#x2013;6</xref>). Previous research has confirmed the existence of information disorder during the COVID-19 vaccination period on several social media platforms (<xref ref-type="bibr" rid="ref7 ref8 ref9 ref10">7&#x2013;10</xref>); including Chile (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref12">12</xref>).</p>
<p>During the COVID-19 pandemic and vaccination rollout, people were exposed to an overwhelming volume of information, much of which was inaccurate or misleading. This excessive flow of content, known as an infodemic, made it increasingly difficult for individuals to distinguish between credible information and misinformation, ultimately shaping their decisions about vaccination (<xref ref-type="bibr" rid="ref13">13</xref>, <xref ref-type="bibr" rid="ref14">14</xref>). Infodemics create a wave of both accurate and inaccurate information, complicating access to clear messages, trustworthy sources, and reliable guidance when people need them most (<xref ref-type="bibr" rid="ref15">15</xref>, <xref ref-type="bibr" rid="ref16">16</xref>). While some information simply generates confusion, other forms can be actively harmful, influencing public perceptions and behaviors that undermine vaccination efforts and public health initiatives (<xref ref-type="bibr" rid="ref15">15</xref>, <xref ref-type="bibr" rid="ref17">17</xref>). Beyond its impact on individuals, the COVID-19 infodemic has had far-reaching societal consequences, eroding trust in health institutions and affecting vaccine confidence and uptake (<xref ref-type="bibr" rid="ref18">18</xref>, <xref ref-type="bibr" rid="ref19">19</xref>).</p>
<p>Despite the global caution call promoted by the World Health Organization (WHO) during the COVID-19 pandemic, societies were inevitably exposed to information disorders. Therefore, while society&#x2019;s had the urgent need to turn to reliable sources of information (<xref ref-type="bibr" rid="ref20">20</xref>, <xref ref-type="bibr" rid="ref21">21</xref>), fact-checking processes on vaccines inaccurate information emerged as essential (<xref ref-type="bibr" rid="ref22 ref23 ref24">22&#x2013;24</xref>). This was Chile&#x2019;s case, which remained not sufficiently addressed.</p>
<p>Considering the previous aspect, the main objective of this study is to identify key characteristics of information disorder addressed by fact-checking media within the vaccination process in Chile. This task is of paramount importance not only due to the substantial risks associated with inaccurate information about the COVID-19 vaccination process but also because of its direct impact on vaccine hesitancy (<xref ref-type="bibr" rid="ref25">25</xref>, <xref ref-type="bibr" rid="ref26">26</xref>). Montagni et al. (<xref ref-type="bibr" rid="ref26">26</xref>) found that individuals categorized as &#x2018;anti-vaccination&#x2019; or &#x2018;vaccine hesitant&#x2019;&#x2014;as opposed to &#x2018;pro-vaccination&#x2019;&#x2014;demonstrate a significantly lower ability to detect false or inaccurate information. Therefore, the objective of this research is relevant because of the fact that 70% of Chileans are unable to distinguish between false and accurate online information (<xref ref-type="bibr" rid="ref12">12</xref>, <xref ref-type="bibr" rid="ref27">27</xref>), which, in turn, has a potential risk on the impact of information disorder, and an opportunity to enhance future communication strategies about inoculation within the country and region (<xref ref-type="bibr" rid="ref28">28</xref>).</p>
</sec>
<sec id="sec6">
<label>2</label>
<title>Literature review</title>
<sec id="sec7">
<label>2.1</label>
<title>Comprehending vaccine information disorder phenomenon</title>
<p>According to the World Health Organization (WHO), an infodemic is <italic>&#x201C;an overabundance of information and the rapid spread of misleading or fabricated news, images, and videos&#x201D;</italic> (<xref ref-type="bibr" rid="ref19">19</xref>). This information overload intensified during the COVID-19 pandemic significantly shaped public perception and decision-making regarding vaccination (<xref ref-type="bibr" rid="ref13">13</xref>, <xref ref-type="bibr" rid="ref14">14</xref>, <xref ref-type="bibr" rid="ref29">29</xref>). For instance, Singh et al. (<xref ref-type="bibr" rid="ref15">15</xref>) found that the excessive circulation of information across media platforms weakened public trust in vaccines and affected their decision to inoculate, while Ouyang et al. (<xref ref-type="bibr" rid="ref17">17</xref>) identified that greater exposure to social media content increased vaccine hesitancy as individuals struggled to process the overwhelming volume of both, accurate and inaccurate information. Beyond influencing vaccination decisions, the infodemic also had a psychological toll, as the constant exposure to contradictory and excessive information led to anxiety, confusion, and emotional fatigue, further complicating people&#x2019;s ability to make informed health choices (<xref ref-type="bibr" rid="ref14">14</xref>, <xref ref-type="bibr" rid="ref30">30</xref>).</p>
<p>The sheer volume of information circulating during the COVID-19 pandemic, as described in the concept of the infodemic, presented a complex challenge. While the term broadly captures the overwhelming influx of information, it is crucial to dissect the nature of this information to understand its precise impact. Simply acknowledging an &#x2018;overabundance&#x2019; does not address the varying degrees of accuracy and intent behind the disseminated content. It becomes necessary to differentiate between various forms of information disorder to move beyond the general description of the infodemic and delve into the specific mechanisms that shaped public perception.</p>
<p>The proliferation of information disorder has led to an excessive eagerness to oversimplify the phenomenon under the label of &#x201C;fake news,&#x201D; contributing to confusion and a failure to distinguish among the various subtleties of the issue (<xref ref-type="bibr" rid="ref27">27</xref>, <xref ref-type="bibr" rid="ref31 ref32 ref33">31&#x2013;33</xref>). Following Wardle and Derakhshan (<xref ref-type="bibr" rid="ref33">33</xref>), this research conceptualizes &#x201C;information disorder&#x201D; as a broad phenomenon of disinformation, misinformation, conspiracy theories, false rumors, and misleading content (<xref ref-type="bibr" rid="ref33">33</xref>, <xref ref-type="bibr" rid="ref34">34</xref>). Wardle and Derakhshan (<xref ref-type="bibr" rid="ref33">33</xref>) identified three types of information disorder: &#x201C;Disinformation,&#x201D; false information created to cause harm; &#x201C;Misinformation,&#x201D; false information spread without harmful intent, and &#x201C;Malinformation,&#x201D; sharing private, real information with the intent to cause harm.</p>
<p>Previous studies have extensively documented the adverse impact of vaccine information disorders on society (<xref ref-type="bibr" rid="ref35 ref36 ref37 ref38">35&#x2013;38</xref>). The correlation between this phenomenon has been confirmed by Montagni et al. (<xref ref-type="bibr" rid="ref26">26</xref>), who found out that &#x201C;being &#x2018;anti-vaccination&#x2019; or &#x2018;hesitant&#x2019;, rather than &#x2018;pro-vaccination&#x2019;, was higher among individuals reporting bad detection of fake news, respectively (&#x2026;), [and that] the risk of being in &#x2018;hesitant&#x2019;, rather than &#x2018;pro-vaccination&#x2019; was higher among individuals having a bad health literacy score&#x201D; (<xref ref-type="bibr" rid="ref26">26</xref>, p. 1). These issues align the WHO decision in 2019 to term &#x201C;vaccine hesitancy&#x201D; as a noxious experience and classify it as one of the top ten significant threats to global public health (<xref ref-type="bibr" rid="ref39">39</xref>).</p>
</sec>
<sec id="sec8">
<label>2.2</label>
<title>Vaccination disinformation in media</title>
<p>Globally, it has been demonstrated that social media platforms are the primary channels for disseminating disinformation (<xref ref-type="bibr" rid="ref12">12</xref>, <xref ref-type="bibr" rid="ref27">27</xref>). During the COVID-19 pandemic, the WHO proposed concrete measures for social media companies to address and control false and/or misleading content, such as reporting incorrect information by users themselves (<xref ref-type="bibr" rid="ref40">40</xref>).</p>
<p>To overcome this threat, the journalistic role performance of fact-checkers has been pivotal (<xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref42">42</xref>). Meanwhile, traditional media mostly privileged a locally scoped domain; digital online communication widely opened instant dissemination of information on a broader scale across a diverse range of topics (<xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref43 ref44 ref45">43&#x2013;45</xref>). Therefore, to regulate information disorders on traditional and social media that could harm citizens by adopting incorrect decisions, fact-checkers news verification task is essential (<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref46">46</xref>). In the case of vaccination processes, it is imperative to scrutinize the phenomenon of information disorder within specific contexts, such as the COVID-19 pandemic.</p>
<p>In the case of vaccine disinformation in the media, there is a lack of studies that analyze this phenomenon. In contrast, a plethora of research has examined the characteristics of information disorder within the context of the COVID-19 pandemic. For example, studies have focused on identifying differences in inaccurate information in several countries, along with components of the type of information disseminated, such as format employed, means of dissemination, primary actors, participants studied, and techniques used, among others (<xref ref-type="bibr" rid="ref47 ref48 ref49">47&#x2013;49</xref>). As a result, scholars agree that the phenomenon may adhere to certain behavioral patterns, such as the election of written text as the most used resource for disseminating inaccurate information (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref22">22</xref>, <xref ref-type="bibr" rid="ref47 ref48 ref49">47&#x2013;49</xref>). In addition, the authors agree that vaccine disinformation varies according to particularities in each context studied (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref50">50</xref>).</p>
<p>On the other hand, scholars have found no consensus regarding the primary social media platform used, the main figure in information disorder, and other variables to consider. Firstly, concerning the leading platform for disseminating information disorder, findings have shown diverse results among Facebook (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref51">51</xref>), WhatsApp (<xref ref-type="bibr" rid="ref52">52</xref>), and multiple social media platforms (<xref ref-type="bibr" rid="ref47">47</xref>, <xref ref-type="bibr" rid="ref48">48</xref>). Additionally, scholars have observed that the main social platform varies depending on the country studied (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref51">51</xref>). Secondly, regarding the leading figures in information disorder, discrepancies have been found between governmental actors (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref47">47</xref>) and public healthcare actors (<xref ref-type="bibr" rid="ref49">49</xref>). Thirdly, numerous other variables to consider include analysis levels &#x2014;including local, national, or global scales&#x2014;; variable choices for specific targets &#x2014;such as celebrities, professionals from the public or private sector, government entities, and more&#x2014;; information format, such as sources used &#x2014;anonymous, fictional, impersonated, or real&#x2014;; and topics under discussion &#x2014;ranging from politics and health to sports and battle conflicts&#x2014;, among others (<xref ref-type="bibr" rid="ref52">52</xref>).</p>
</sec>
</sec>
<sec id="sec9">
<label>3</label>
<title>Objective</title>
<p>Since COVID-19 information disorder emerged, vaccine hesitancy has become significantly challenging worldwide (<xref ref-type="bibr" rid="ref26">26</xref>, <xref ref-type="bibr" rid="ref53">53</xref>, <xref ref-type="bibr" rid="ref54">54</xref>). In this context, Chile is an attractive case study (<xref ref-type="bibr" rid="ref55">55</xref>). Historically, this country has been well known for its culture related to high vaccine acceptability, which, in turn, projected high vaccination rates to face the COVID-19 pandemic (<xref ref-type="bibr" rid="ref56 ref57 ref58">56&#x2013;58</xref>). However, before and after the inoculation process, vaccine intention has been lower than expected (<xref ref-type="bibr" rid="ref12">12</xref>, <xref ref-type="bibr" rid="ref59">59</xref>, <xref ref-type="bibr" rid="ref60">60</xref>).</p>
<p>Until today, research studies in this country have examined information disorder during the pandemic independently (<xref ref-type="bibr" rid="ref34">34</xref>, <xref ref-type="bibr" rid="ref61">61</xref>) and comparatively with other countries (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref51">51</xref>, <xref ref-type="bibr" rid="ref62">62</xref>, <xref ref-type="bibr" rid="ref63">63</xref>). Nevertheless, despite the well-documented prevalence of inaccurate information regarding the COVID-19 vaccination process (<xref ref-type="bibr" rid="ref64">64</xref>, <xref ref-type="bibr" rid="ref65">65</xref>), specific characteristics of this information disorder in Chile remain unexplored. Therefore, this study aims to identify the main characteristics of information disorder that circulated in Chile during the COVID-19 vaccination process, focusing on key topics, actors, and media platforms involved. To achieve this, we address the following research questions:</p>
<p>RQ1: What are the main characteristics of information disorder dealing with fact-checking related to the COVID-19 vaccination process in Chile?</p>
<p>RQ2: What were the main topics surrounding information disorder addressed by fact-checking media during the COVID-19 vaccination process in Chile?</p>
<p>RQ3: Which were the key actors in the information disorder during the COVID-19 vaccination process in Chile?</p>
<p>RQ4: What were the media platforms through which information disorder circulated during the COVID-19 vaccination process in Chile?</p>
</sec>
<sec sec-type="methods" id="sec10">
<label>4</label>
<title>Methods</title>
<p>To answer the research questions, we applied a quantitative research approach using the content analysis technique (<xref ref-type="bibr" rid="ref66">66</xref>). Based on the fact of comparing the same phenomenon coming from different bodies of texts, we examined articles that belonged to Chilean fact-checking websites: (a) FastCheck.cl, and (b) MalaEspinaCheck.cl, both regarding COVID-19 vaccines. These fact-checking sites were chosen as both media outlets were primary verifiers of viral information related to the pandemic and the only ones that corroborated information disorders pertaining to the COVID-19 vaccination process in Chile. The period explored corresponded from March 2020 to December 2022, considering the period since the COVID-19 pandemic emerged in this country until this paper was produced. The selection criteria applied were based on topics related to the following keywords: vaccines, vaccination, or vaccination process.</p>
<sec id="sec11">
<label>4.1</label>
<title>Procedures</title>
<p>A total of 226 fact-checking articles were initially obtained. Only those fact-checks classified as containing inaccurate, false, or decontextualized information were selected from them. Therefore, the final sample was composed of a total of 140 texts. Articles that were not fact-checked were not considered in this research, as they do not align with the research questions.</p>
</sec>
<sec id="sec12">
<label>4.2</label>
<title>Measures</title>
<p>The selected articles were analyzed based on variables aimed to identify the main characteristics related to false information on vaccination that circulated during COVID-19 in Chile. The operationalization of the variables used to analyze this information disorder was based on previous research during the COVID-19 pandemic (<xref ref-type="bibr" rid="ref8">8</xref>, <xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref12">12</xref>, <xref ref-type="bibr" rid="ref27">27</xref>, <xref ref-type="bibr" rid="ref49">49</xref>, 52, <xref ref-type="bibr" rid="ref67">67</xref>). The variables considered for this study were operationalized as follows:</p>
<list list-type="bullet">
<list-item><p>Scope: We analyzed the context of the information regarding its location in three categories: (1) local, (2) national, and (3) international.</p></list-item>
<list-item><p>Format: Considering the primary format of each fact-checking article, we categorized its content as mainly: (1) text, (2) audio, (3) video, (4) image, (5) infographic, and (6) more than one format.</p></list-item>
<list-item><p>Media Platform: We categorized the media platform used through which information disorder related to vaccine information circulated: (1) WhatsApp, (2) YouTube, (3) Facebook, (4) Instagram, (5) Twitter, (6) others, (7) multiple social media, and (8) traditional media.</p></list-item>
<list-item><p>Source: Considering the source of information disorder, we categorized them as (1) fictional, (2) impersonated, (3) real, and (4) anonymous.</p></list-item>
<list-item><p>Topics: Based on the literature review, we proposed to classify four topic categories: (1) vaccine side effects, (2) vaccine components, (3) elite power conspiracies, (4) others, and (5) more than one of the categories.</p></list-item>
<list-item><p>Key actors: We identified who the main character of the information disorder was distinguishing among: (1) public health actors (individuals or institutions), (2) medical or research professionals (not public actors), (3) political or institutional actors, (4) non-political public actors (individuals or institutions), (5) without a central figure, and (6) collectives.</p></list-item>
<list-item><p>Type of Information Disorder: Based on the categorization proposed by Wardle and Derakhshan (<xref ref-type="bibr" rid="ref33">33</xref>), we identified the primary types of information disorder used: (1) misinformation, (2) disinformation, and (3) malinformation.</p></list-item>
<list-item><p>Subject: We categorized the field or area of information disorder as mainly (1) science/health, (2) politics/government, (3) elite/economic/private groups (non-government), and (4) others.</p></list-item>
<list-item><p>Type of Strategy: Based on the different types of strategies used to spread information disorder, we categorized them into (1) hoax, (2) exaggeration, (3) decontextualization, and (4) deception.</p></list-item>
</list>
</sec>
<sec id="sec13">
<label>4.3</label>
<title>Data analysis</title>
<p>The extracted data was analyzed according to the variables operationalized by two coders, who used each fact-checking article as their analysis unit. First, we constructed a coding sheet, including all the operationalized variables. Second, to accomplish this task reliably, we calculated inter-coder reliability (ICR) standards (<xref ref-type="bibr" rid="ref68">68</xref>) from a selected sample of 26 articles, corresponding to 10% of the original sample. As a result, both coders met a coder agreement ranging from 90.6% (Krippendorff&#x202F;=&#x202F;0.80) to 100% (Krippendorff&#x202F;=&#x202F;1.0).</p>
<p>Once the coding phase was completed, we performed statistical analysis focusing on the research questions of this study. Research questions 1, 2, 3, and 4 were answered through descriptive statistics analyses. Meanwhile, the Chi-square test was used to examine the association between variables. When the assumptions of the Chi-square test were violated, the Monte Carlo test was used to ensure the accuracy of the results. In the next section, we will present our study results and, later, discuss the implications of our findings.</p>
</sec>
</sec>
<sec sec-type="results" id="sec14">
<label>5</label>
<title>Results</title>
<p>During the selected period, from March 2020 to December 2022, the fact-checking articles produced by FastCheck.cl and MalaEspincaCheck.cl were examined. Our initial analysis found that according to each of them: (a) FastCheck.cl produced a total of 1,272 fact-checking articles on several topics (economy, politics, science, health, etc.). Out of these, a total of 273 were related to the COVID-19 pandemic, representing 21.5% of the total; from which, 81 were specifically on the COVID-19 vaccine or vaccination process (6.4% of the total); and (b) MalaEspinaCheck.cl produced 606 articles on different topics from which 136 were related to the COVID-19 pandemic, corresponding to 22.4% of the total; meanwhile only 59 of them addressed specifically COVID-19 vaccine or the vaccination process (9.7% of the total).</p>
<sec id="sec15">
<label>5.1</label>
<title>RQ1: main characteristics of information disorder related to the COVID-19 vaccination process in Chile</title>
<p>Results of our analysis showed that most of the topics came from international sources, corresponding to 73.6% of the sample; meanwhile, the remaining percentage correlated with Chilean sources.</p>
<p>The most used format for the circulation of informational disorders was text, corresponding to 32.9% (<italic>n</italic>&#x202F;=&#x202F;49) of the sample, followed by videos (28.6%, <italic>n</italic>&#x202F;=&#x202F;40) and photography (18.6%, <italic>n</italic>&#x202F;=&#x202F;26). More than one format for the diffusion of inaccurate information corresponded to 19.3% (<italic>n</italic>&#x202F;=&#x202F;27) of the cases related to the vaccine and/or the vaccination process against COVID-19. More details are presented in <xref ref-type="fig" rid="fig1">Figure 1</xref>.</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>Format used to disseminate information disorder about the vaccination process in Chile. Source: author&#x2019;s own work.</p>
</caption>
<graphic xlink:href="fpubh-13-1399336-g001.tif"/>
</fig>
<p>Concerning the frequency distribution of sources that disseminate inaccurate information, we found out that: (a) 62.9% (<italic>n</italic>&#x202F;=&#x202F;88) of the sources corresponded to real people who did or said what was stated; (b) 25.7% (<italic>n</italic>&#x202F;=&#x202F;36) of the cases were impersonated sources and, finally, (c) 11.4% (<italic>n</italic>&#x202F;=&#x202F;16) of the sources used were anonymous.</p>
<p>No cases of malinformation were registered from the total sample of 140 verifications carried out by Fast Check and Mala Espina. On the contrary, 91.4% (<italic>n</italic>&#x202F;=&#x202F;128) of the rectified notes responded to disinformation cases; the remaining cases belonged to misinformation. To illustrate this finding, in <xref ref-type="table" rid="tab1">Table 1</xref>, we present the most representative statements that were found in the fact-checking articles studied.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Examples of types of information disorders identified in this study.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Type of information disorder</th>
<th align="left" valign="top">Topics</th>
<th align="left" valign="top">Examples</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="3">Disinformation</td>
<td align="left" valign="top">Vaccine side effects</td>
<td align="left" valign="top">
<list list-type="bullet">
<list-item>
<p>The 30% of those vaccinated will die within a few months.</p>
</list-item>
<list-item>
<p>By court order, a pharmaceutical company had to acknowledge that 82 to 97% of pregnant women who were inoculated aborted their baby.</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="top">Vaccine components</td>
<td align="left" valign="top">
<list list-type="bullet">
<list-item>
<p>A pharmaceutical company vaccine is produced using cells from aborted fetuses.</p>
</list-item>
<list-item>
<p>They have introduced graphene into our bodies.</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="top">Elite power conspiracies</td>
<td align="left" valign="top">
<list list-type="bullet">
<list-item>
<p>Breaking News! A document has emerged in which a pharmaceutical company gives 2.8 million to the FDA to expedite the approval of their COVID vaccine! Irrefutably exposed bribery!</p>
</list-item>
<list-item>
<p>The World Health Organization (WHO) has stated that the COVID-19 pandemic would end in a few months without the need for vaccination. #plandemic</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Misinformation</td>
<td align="left" valign="top">Vaccine side effects</td>
<td align="left" valign="top">
<list list-type="bullet">
<list-item>
<p>&#x2212;30 people fainted after receiving doses of the vaccine from a pharmaceutical company in Las Condes.</p>
</list-item>
<list-item>
<p>Changes in menstruation and breast issues? Other effects of the COVID-19 vaccine.</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="top">vaccine components</td>
<td align="left" valign="top">
<list list-type="bullet">
<list-item>
<p>Graphene is one of the components of the vaccine.</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="top">Malinformation</td>
<td align="left" valign="top">No data</td>
<td align="left" valign="top">No data was found.</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Source: author&#x2019;s own work.</p>
</table-wrap-foot>
</table-wrap>
<p>Regarding the subject of information disorder, 70% (<italic>n</italic>&#x202F;=&#x202F;98) of the articles studied corresponded to the field of science and health, which included topics related to vaccination and/or people&#x2019;s health. In contrast, 17.8% (<italic>n</italic>&#x202F;=&#x202F;25) of the cases were on politics and/or government &#x2014;such as political parties, their members, and governmental matters&#x2014;; meanwhile, the remaining 9.3% (<italic>n</italic>&#x202F;=&#x202F;13) and 2.9% (<italic>n</italic>&#x202F;=&#x202F;4) corresponded to inaccurate information linked to elite groups &#x2014;which considered individuals or groups of people (companies) associated with economic and private power but not from the public sector&#x2014;, and other areas, respectively.</p>
<p>Finally, the most used information disorder strategy was (a) deception, accounting for 64.3% (<italic>n</italic>&#x202F;=&#x202F;90), and (b) decontextualization, corresponding to 32.9% (<italic>n</italic>&#x202F;=&#x202F;46) of the sample. Pranks and exaggerations accounted for 1.4% (<italic>n</italic>&#x202F;=&#x202F;2), and although the literature acknowledges that both techniques can be highly utilized in disinformation contexts, they were scarcely identified in this study. For more information, see <xref ref-type="fig" rid="fig2">Figure 2</xref>.</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>Main characteristics of information disorder related to the COVID-19 vaccination process in Chile. Source: author&#x2019;s own work.</p>
</caption>
<graphic xlink:href="fpubh-13-1399336-g002.tif"/>
</fig>
<p>We additionally analyzed the association between the information source variables and the most used information disorder strategy through chi-square tests. As a result, we identified a significant association when a real source was used with the deception strategy (32.9%, <italic>n</italic>&#x202F;=&#x202F;46), followed by the decontextualization of information (27.9%, <italic>n</italic>&#x202F;=&#x202F;39). Besides, the supplant and anonymous source information also tended to be more commonly used with the deception technique, accounting for 20.7% (<italic>n</italic>&#x202F;=&#x202F;27) and 10.7% (<italic>n</italic>&#x202F;=&#x202F;15), respectively.</p>
</sec>
<sec id="sec16">
<label>5.2</label>
<title>RQ2: main topics surrounding information disorder addressed by fact-checking media during the COVID-19 vaccination process in Chile</title>
<p>Results showed that 45% (<italic>n</italic>&#x202F;=&#x202F;63) of fact-checking articles had as main topic vaccination side effects. Mainly, in those articles where scientific evidence was not provided, adverse reactions such as fainting or even death were attributed. Secondly, findings revealed that 20% (<italic>n</italic>&#x202F;=&#x202F;28) of the articles addressed different topics than those proposed in our variable&#x2019;s classification. However, these topics were diverse and did not follow a specific trend. Thirdly, 16.4% (<italic>n</italic>&#x202F;=&#x202F;23) of the articles addressed the topic of conspiracies by power elites. In them, the most recurring themes were affirming that the pandemic and vaccines were a global plan orchestrated by different power groups. In addition, attacks were constantly carried out on pharmaceutical companies and its managers, accusing them of hiding relevant information. Fourthly, 10.7% (<italic>n</italic>&#x202F;=&#x202F;15) of fact-checking articles focused on the components of the vaccines. In this topic, it was recurrent to find disinformation claiming that vaccines were composed of graphene or aborted fetal cells. Finally, 7.9% (<italic>n</italic>&#x202F;=&#x202F;11) of the articles studied presented more than one topic. In conclusion, 80% of the articles analyzed were related to the topics of side effects, components, and elite conspiracy, indicating their relevance during the COVID-19 vaccination process. More details are presented in <xref ref-type="fig" rid="fig3">Figure 3</xref>.</p>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>Issues of information disorder in the vaccination process in Chile. Source: author&#x2019;s own work.</p>
</caption>
<graphic xlink:href="fpubh-13-1399336-g003.tif"/>
</fig>
<p>In addition, a Chi-square test revealed a significant association between the variables topic and the type of technique used. The results indicated that when the main theme of the stories was secondary effects, the most used disinformation technique was deception (25%, <italic>n</italic>&#x202F;=&#x202F;35), followed by the decontextualization of the information (20%, <italic>n</italic>&#x202F;=&#x202F;28). The trend was maintained in the other areas, although to a lesser extent. Specifically, when the topic was vaccine components, the deception technique was used (8.6%, <italic>n</italic>&#x202F;=&#x202F;12), followed by decontextualization (2.1%, <italic>n</italic>&#x202F;=&#x202F;3); and when the theme was a conspiracy by power elites, the most used technique was deception (11.4%, <italic>n</italic>&#x202F;=&#x202F;16), followed by decontextualization (4.3%, <italic>n</italic>&#x202F;=&#x202F;6).</p>
</sec>
<sec id="sec17">
<label>5.3</label>
<title>RQ3: key actors in the information disorder during the COVID-19 vaccination process in Chile</title>
<p>We found that 66.4% (<italic>n</italic>&#x202F;=&#x202F;93) of the cases corresponded to non-public health professionals, revealing that key actors were individuals representing a pharmaceutical company or private sector medical professionals. In contrast, individuals coming from the public sector, such as the Ministry of Health or any state institution, accounted only for 10% (<italic>n</italic>&#x202F;=&#x202F;14) of the total sample. In addition, 9.3% (<italic>n</italic>&#x202F;=&#x202F;13) of the sample were non-political public figures, such as athletes or actors; meanwhile, 8.6% (<italic>n</italic>&#x202F;=&#x202F;12) of the time, political actors were the main characters. In 1.4% (<italic>n</italic>&#x202F;=&#x202F;2) of the cases, the main figure was not an individual person but a collective, and in 4.3%, no protagonist of any kind was detected within the shared story. More details are presented in <xref ref-type="fig" rid="fig4">Figure 4</xref>.</p>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption>
<p>Key actors of information disorder in the vaccination process in Chile. Source: author&#x2019;s own work.</p>
</caption>
<graphic xlink:href="fpubh-13-1399336-g004.tif"/>
</fig>
<p>In addition, Chi-square tests revealed a statistically significant association between key actors and topic variables, revealing that the most relevant characters disseminated through misinformation were non-public medical professionals, such as researchers, pharmaceutical professionals, or healthcare personnel. These last characters tended to have the greater presence in all the topics addressed as follows: 35% (<italic>n</italic>&#x202F;=&#x202F;49) in topics related to side effects, 7.9% (<italic>n</italic>&#x202F;=&#x202F;11) in vaccine components, 8.6% (<italic>n</italic>&#x202F;=&#x202F;12) in elite conspiracy, 7.9% (<italic>n</italic>&#x202F;=&#x202F;11) in other topics, and 7.1% (<italic>n</italic>&#x202F;=&#x202F;10) when more than one of the topics was mentioned.</p>
</sec>
<sec id="sec18">
<label>5.4</label>
<title>RQ4: media platform through which information disorder circulated during the COVID-19 vaccination process in Chile</title>
<p>We identified that 52.9% (<italic>n</italic>&#x202F;=&#x202F;74) of the information disorder tended to circulate through more than one media outlet, following this trend: 13.6% (<italic>n</italic>&#x202F;=&#x202F;19) circulated exclusively on Twitter, 12.1% (<italic>n</italic>&#x202F;=&#x202F;17) on Instagram, 8.6% (<italic>n</italic>&#x202F;=&#x202F;12) on Facebook, 5.7% (<italic>n</italic>&#x202F;=&#x202F;8) through other types of media like Telegram or websites, 4.3% (<italic>n</italic>&#x202F;=&#x202F;6) on WhatsApp, 2.1% (<italic>n</italic>&#x202F;=&#x202F;3) through traditional media, and only 0.7% (<italic>n</italic>&#x202F;=&#x202F;1) via YouTube. More details are presented in <xref ref-type="fig" rid="fig5">Figure 5</xref>.</p>
<fig position="float" id="fig5">
<label>Figure 5</label>
<caption>
<p>Media platform of information disorder circulation in the vaccination process in Chile. Source: author&#x2019;s own work.</p>
</caption>
<graphic xlink:href="fpubh-13-1399336-g005.tif"/>
</fig>
</sec>
</sec>
<sec sec-type="discussion" id="sec19">
<label>6</label>
<title>Discussion</title>
<p>This research proposes a novel approach as disinformation disorder about the vaccination process during the COVID-19 pandemic is studied for the first time in Chile. This is important because it provides a foundation for future research related to the vaccination process and the COVID-19 pandemic in a Latin American country that has not yet been studied. In addition, the fact of analyzing information disorder directly from two of the main fact-checking media outlets in Chile &#x2014;Fast Check and Mala Espina&#x2014; provided an incommensurable contribution as they belong to the International Fact-Checking Network (IFCN) and are responsible for corroborating inaccurate information related to the COVID-19 vaccination process and the vaccine itself.</p>
<p>Within the public discourse surrounding the COVID-19 vaccine infodemic worldwide, the findings of this study confirm similarities with specialized literature as well as specific characteristics of the information disorder present in Chile. In addressing RQ1, it was observed that text was the most used format for disseminating false information (32.9%, <italic>n</italic>&#x202F;=&#x202F;49), as noted in previous studies in Spain and Italy (<xref ref-type="bibr" rid="ref48">48</xref>, <xref ref-type="bibr" rid="ref52">52</xref>), this study revealed a more significant prevalence of visual representation. Videos and images together accounted for 47.2% (<italic>n</italic>&#x202F;=&#x202F;66). This constitutes a novel finding that requires further and more research, as the pivotal role of visuals in information disorder is getting more common each day.</p>
<p>Another relevant finding addressing RQ2 showed that vaccine side effects (45%, <italic>n</italic>&#x202F;=&#x202F;63) and vaccine components (10.7%, <italic>n</italic>&#x202F;=&#x202F;15) were fundamental topics presented, both belonging to the area of science/health. These findings follow the trend of other research in Latin America, Spain, and China that has also identified a constant effort to discredit vaccines and the health sector (<xref ref-type="bibr" rid="ref3">3</xref>, <xref ref-type="bibr" rid="ref51">51</xref>, <xref ref-type="bibr" rid="ref69">69</xref>). This is particularly significant given that previous studies in the United States and Portugal have found that concerns about COVID-19 vaccine safety were strong predictors of vaccine hesitancy (<xref ref-type="bibr" rid="ref70">70</xref>, <xref ref-type="bibr" rid="ref71">71</xref>). Therefore, the spread of information disorder regarding COVID-19 vaccine safety could negatively impact people&#x2019;s willingness to vaccinate. Besides this finding, elite power conspiracy constitutes a crucial influence that is present in Chilean information disorder in the vaccination process. The danger of these lies in the credibility they can gain in society because, mainly being based on false or out-of-context information, they appear more believable and can motivate people to share and propagate inaccurate information within their social circles, exacerbating vaccine skepticism or rejection, which, in turn, hindered the fight against the pandemic.</p>
<p>Given this context, the complexity involved in creating and disseminating vaccine-related information disorder highlights the need to implement innovative tools to mitigate its potential harm to public trust and vaccine acceptance. For example, prior research has demonstrated that AI technologies can play a critical role in pandemic management by accelerating diagnostic processes and supporting risk assessment (<xref ref-type="bibr" rid="ref16">16</xref>, <xref ref-type="bibr" rid="ref21">21</xref>, <xref ref-type="bibr" rid="ref72">72</xref>). Although these studies primarily focus on the clinical and epidemiological aspects of COVID-19, the reasoning behind using AI for rapid data processing and decision-making also applies to the early detection and containment of information disorder. These tools present promising opportunities for supporting evidence-based communication strategies and reducing the spread of inaccurate information during health emergencies.</p>
<p>Regarding RQ3, our results revealed that 66.4% (<italic>n</italic>&#x202F;=&#x202F;93) of the cases corresponded to non-public health professionals, such as medical or research professionals. This specific finding differs from the literature review in which scholars had proven that during the pandemic, governmental actors (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref47">47</xref>) and public healthcare actors (<xref ref-type="bibr" rid="ref49">49</xref>) were the main figures of information disorder. We believe that this disparate result is explained by the fact that the subject of science/health was the most prominent area that emerged from our analysis. Vaccines and their side effects correspond to the topic addressed mainly by health professionals belonging to pharmaceutical companies or private health organizations that were not well known by the Chilean public. Therefore, these key actors were not considered public figures, as clearly identified by most of the Chilean people. Nevertheless, this last hypothesis requires further investigation in future studies.</p>
<p>Finally, analyzing the primary media platforms through which inaccurate information circulated in Chile (RQ4), it is important to note the complexity of how any form of information disorder spreads. Specifically, in contrast to other countries (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref51">51</xref>), in Chile, the same piece of information disorder tends to be repeated across various media simultaneously &#x2014;Twitter, Facebook, Instagram, and WhatsApp&#x2014;. This follows the trend observed by authors such as L&#x00F3;pez-Mart&#x00ED;n and C&#x00F3;rdoba-Cab&#x00FA;s (<xref ref-type="bibr" rid="ref73">73</xref>) and Skafle et al., (<xref ref-type="bibr" rid="ref74">74</xref>) in Europe and USA. One of the reasons that we hold for this alarming result is that it makes it challenging to identify the origin or party responsible for the information disorder. This last issue intensifies the impact of information disorder as social media platforms have exacerbated this problem due to its immediacy. According to Morej&#x00F3;n-Llamas (<xref ref-type="bibr" rid="ref51">51</xref>), in the Latin American region, information disorder can take between 2.2 and 67&#x202F;days to be verified and debunked by fact-checking organizations, which corresponds to a crucial time in which information disorder can or may have a significant impact on societies well-being. In addition, given the fact that primary media platforms for information disorder circulation are similar in Chile and other Latin American countries, it would be helpful to propose joint regulatory strategies to address this issue. As suggested by researchers in other contexts, such as Europe, collaborative approaches may help address this issue (<xref ref-type="bibr" rid="ref75 ref76 ref77 ref78 ref79">75&#x2013;79</xref>).</p>
</sec>
<sec sec-type="conclusions" id="sec20">
<label>7</label>
<title>Conclusion</title>
<p>This study identifies the main characteristics of the information disorder circulated in Chile during the COVID-19 vaccination process. It is important to highlight that this study primarily focused on science/health. At the same time, the theoretical framework of information disorder usually considers general topics and does not reach specific themes such as vaccination processes. Also, in the Chilean case, it is relevant to notice the lack of fact-checking processes (<xref ref-type="bibr" rid="ref67">67</xref>). However, FastCheck.cl and MalaEspinaCheck.cl do relevant work, as they also belong to the International Fact-Checking Network. Nevertheless, Chile is ranked as one of the countries with the lowest number of fact-checks related to COVID-19 and the vaccination process (<xref ref-type="bibr" rid="ref51">51</xref>, <xref ref-type="bibr" rid="ref80">80</xref>), health communication scholars need to understand the importance of fact-checking health information disorders, specifically related to vaccination (<xref ref-type="bibr" rid="ref35">35</xref>, <xref ref-type="bibr" rid="ref75">75</xref>) due the potential influence that information disorder can have on vaccination processes.</p>
<sec id="sec21">
<label>7.1</label>
<title>Limitations</title>
<p>Firstly, the selected sample is small, reflecting the low number of verifications conducted in the country during the studied period. Therefore, it would be interesting to reply to this same research in other Latin American countries with more vaccine disorder information to study. And secondly, this work focused only on quantitative research areas. Therefore, it is also necessary to examine the qualitative context or frames in which vaccination processes, as in the Chilean case, were lived. Thus, this research needs to be deepened by other health communication scholars.</p>
</sec>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="sec22">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary materials, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="author-contributions" id="sec23">
<title>Author contributions</title>
<p>AC: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing &#x2013; original draft. VS: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing &#x2013; original draft. EA: Project administration, Supervision, Writing &#x2013; review &#x0026; editing. CM-L: Project administration, Supervision, Writing &#x2013; review &#x0026; editing. AK: Project administration, Resources, Supervision, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec sec-type="funding-information" id="sec24">
<title>Funding</title>
<p>The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by the Millennium Institute on Immunology and Immunotherapy [ANID-Millennium Science Initiative Program ICN09_016 (former P09/016F)], the VRI (Vicerrectoria de Investigaci&#x00F3;n grant number 2023-2810 to V.S.), the Agencia Nacional de Investigaci&#x00F3;n y Desarrollo (ANID grant number 21231176 to AC) and Fondecyt #1231851 (AMK).</p>
</sec>
<sec sec-type="COI-statement" id="sec25">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="sec26">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<ref-list>
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