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<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
<issn pub-type="epub">2296-2565</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2023.1257131</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>A study on the prevalence of smoking habits among the student community in Aseer Region, Saudi Arabia</article-title>
</title-group>
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<contrib contrib-type="author" corresp="yes">
<name><surname>Kandasamy</surname> <given-names>Geetha</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
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<contrib contrib-type="author">
<name><surname>Sam</surname> <given-names>Gigi</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
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<contrib contrib-type="author">
<name><surname>Almanasef</surname> <given-names>Mona</given-names></name>
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<contrib contrib-type="author">
<name><surname>Almeleebia</surname> <given-names>Tahani</given-names></name>
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<contrib contrib-type="author">
<name><surname>Shorog</surname> <given-names>Eman</given-names></name>
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<contrib contrib-type="author">
<name><surname>Alshahrani</surname> <given-names>Asma M.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
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<name><surname>Almohaimeed</surname> <given-names>Rana A.</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
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<name><surname>Hmlan</surname> <given-names>Amjad</given-names></name>
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<contrib contrib-type="author">
<name><surname>Al Suhaym</surname> <given-names>Atheer Y.</given-names></name>
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<name><surname>Prabahar</surname> <given-names>Kousalya</given-names></name>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref>
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<name><surname>Veeramani</surname> <given-names>Vinoth Prabhu</given-names></name>
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<name><surname>Amirthalingam</surname> <given-names>Palanisamy</given-names></name>
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<contrib contrib-type="author">
<name><surname>Mohammed Shorog</surname> <given-names>Basmah</given-names></name>
<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
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<contrib contrib-type="author">
<name><surname>Mani</surname> <given-names>Vasudevan</given-names></name>
<xref ref-type="aff" rid="aff7"><sup>7</sup></xref>
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<aff id="aff1"><sup>1</sup><institution>Department of Clinical Pharmacy, College of Pharmacy, King Khalid University</institution>, <addr-line>Abha</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff2"><sup>2</sup><institution>Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University</institution>, <addr-line>Dawadmi</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Clinical Pharmacy, College of Pharmacy, King Saud University</institution>, <addr-line>Riyadh</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff4"><sup>4</sup><institution>Eradah Hospital for Mental Health in Jazan, Ministry of Health</institution>, <addr-line>Jazan</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff5"><sup>5</sup><institution>Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk</institution>, <addr-line>Tabuk</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff6"><sup>6</sup><institution>Department of Family and Community Medicine, Armed Forces Hospital Southern Region</institution>, <addr-line>Khamis Mushait</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff7"><sup>7</sup><institution>Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University</institution>, <addr-line>Buraydah</addr-line>, <country>Saudi Arabia</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Ahmad Hanani, An-Najah National University, Palestine</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Ahmed Mohammed Alwan Albuhamad, Al-Manara College for Medical Sciences, Iraq</p>
<p>Mariam Al_Tell, An-Najah National University, Palestine</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Geetha Kandasamy <email>glakshmi&#x00040;kku.edu.sa</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>22</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>11</volume>
<elocation-id>1257131</elocation-id>
<history>
<date date-type="received">
<day>12</day>
<month>07</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>28</day>
<month>11</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2023 Kandasamy, Sam, Almanasef, Almeleebia, Shorog, Alshahrani, Almohaimeed, Hmlan, Al Suhaym, Prabahar, Veeramani, Amirthalingam, Mohammed Shorog and Mani.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Kandasamy, Sam, Almanasef, Almeleebia, Shorog, Alshahrani, Almohaimeed, Hmlan, Al Suhaym, Prabahar, Veeramani, Amirthalingam, Mohammed Shorog and Mani</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<sec>
<title>Objectives</title>
<p>A cross-sectional study was aimed to assess the prevalence of smoking habits among students at King Khalid University (KKU), Abha, KSA.</p>
</sec>
<sec>
<title>Methods</title>
<p>This was a cross-sectional study using a Modified Fagerstrom Tolerance Questionnaire (mFTQ), online survey was carried out among the students of KKU. This tool uses a five-point Likert scale for all seven questions, except one question on smoking during the first 2 h of the day.</p>
</sec>
<sec>
<title>Results</title>
<p>The prevalence of smoking among male students was 67% (<italic>n</italic> = 243) and females 33% (<italic>n</italic> = 122). Of the current cigarette smokers, 19% had a nicotine dependence score of &#x02265;6 (high), 48% scored 4&#x02013;6 (moderate) and 33% scored &#x0003C;4 (minimal). Association between mFTQ and the number of cigarettes per day (<italic>p</italic> &#x0003C; 0.001), first smoke of your cigarettes (<italic>p</italic> &#x0003C; 0.018), smoking in the morning (<italic>p</italic> &#x0003C; 0.007), and difficulty refraining from smoking in public areas (<italic>p</italic> &#x0003C; 0.000). The results of the current study recommend that cigarette smoking habits are a significant risk behavior among young students. The strength of this study signifies that most participants (62%) intend to quit if appropriately supported.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>According to the findings of the current investigation, smoking was quite common among males. It raises the alarm about the critical need for adequate education to support health education initiatives, discourage teen smoking, and enhance health outcomes for the community.</p>
</sec></abstract>
<kwd-group>
<kwd>cigarette smoking</kwd>
<kwd>prevalence</kwd>
<kwd>mFTQ</kwd>
<kwd>awareness</kwd>
<kwd>quit smoking</kwd>
<kwd>students</kwd>
</kwd-group>
<contract-num rid="cn001">RGP2/150/44</contract-num>
<contract-sponsor id="cn001">Deanship of Scientific Research, King Khalid University<named-content content-type="fundref-id">10.13039/501100023674</named-content></contract-sponsor>
<counts>
<fig-count count="0"/>
<table-count count="4"/>
<equation-count count="0"/>
<ref-count count="34"/>
<page-count count="7"/>
<word-count count="5683"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Substance Use Disorders and Behavioral Addictions</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="s1">
<title>1 Introduction</title>
<p>Smoking is a significant global contributor to avoidable morbidity and mortality. Each year, smoking causes six million deaths worldwide. According to data from the World Health Organization (WHO), it is predicted to exceed eight million by 2030 (<xref ref-type="bibr" rid="B1">1</xref>). Many diseases and fatalities that may be avoided are brought on by tobacco use, in all of its forms. Around seven million individuals died worldwide in 2016 from diseases related to tobacco use, according to a 2018 report (<xref ref-type="bibr" rid="B2">2</xref>). By 2030, eight million people are expected to die each year from tobacco-related diseases if current trends continue (<xref ref-type="bibr" rid="B3">3</xref>). In spite of the fact that tobacco usage has decreased in many developed nations, 80% of the 1.1 billion current smokers who reside in these nations continue to bear the cost of tobacco-related illness and mortality (<xref ref-type="bibr" rid="B2">2</xref>). In addition, it was discovered that smoking rates increased statistically significantly between 1980 and 2012 in various high-income nations, including the Kingdom of Saudi Arabia (KSA) (<xref ref-type="bibr" rid="B4">4</xref>). From 2010 to 2014, the KSA imported tobacco goods valued at around US$ 3.4 billion (<xref ref-type="bibr" rid="B5">5</xref>). As a result, smoking cost the KSA 20.5 billion US dollars, and between 2001 and 2010 there were 280,000 premature deaths (<xref ref-type="bibr" rid="B6">6</xref>). The KSA has established specific regulations to regulate and lower tobacco consumption for the past three decades (<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B8">8</xref>). The use of tobacco products is prohibited at government and affiliated institutions, including college campuses, parks, shopping centers, airports, and other public areas that have been designated as tobacco-free zones. Another law taxes tobacco products at a rate of 100%. In June 2017, the most recent price rise for tobacco products went into effect (<xref ref-type="bibr" rid="B7">7</xref>). Nonetheless, smoking remains a serious problem among Saudi college students (<xref ref-type="bibr" rid="B9">9</xref>).</p>
<p>One of the top 10 cigarette importers worldwide is KSA. In 2010, a study of 2,564 Saudi students revealed that 8.9% of the participants were active smokers (<xref ref-type="bibr" rid="B10">10</xref>). Consuming tobacco is linked to a number of illnesses that can affect both sexes, including various cardiovascular, respiratory, and gastrointestinal conditions. However, reproductive system disorders specific to women, such as miscarriages, preterm birth, low birth weight, and possibly sudden infant death syndrome, are also present. Smoking has health implications on young people even though many of the harmful effects of tobacco appear later in life (<xref ref-type="bibr" rid="B11">11</xref>).</p>
<p>Tobacco is commonly used as smoking and smokeless forms of tobacco. Tobacco smoking is usually done in the form of cigarettes, pipe tobacco, and cigars. Worldwide current smokers of cigarettes are found to be 1.3 billion.</p>
<p>The overall prevalence of smoking is 29% of which 47.5% are men and 10.3% are women. Every year usage of tobacco is increasing by around 3.4%.</p>
<p>In addition reports from another study show that the prevalence rate is 13.6% among students of medicine Abha, KSA (<xref ref-type="bibr" rid="B12">12</xref>). Only a few studies have shown to find out the prevalence of smoking among adolescents in Saudi Arabia. The production of tobacco and its derivatives is forbidden in Saudi Arabia, By Royal Decree No. (M/56) of the Saudi Amended Anti-smoking Law, dated May 17, 2015. The term &#x0201C;smoking&#x0201D; refers to the consumption of tobacco and its derivatives, including cigarettes, cigars, tobacco leaves, tobacco molasses, and any other product containing tobacco, whether smoked as cigarettes or cigars, through the use of a pipe or shisha by chewing, sniffing or any other means. At the following locations, smoking is not permitted. (1) Mosques surrounding area and yards. (2) Ministries, government bureaus, public institutions, their branches, and other public organizations. (3) Employment spaces in businesses, organizations, factories, banks, and the government. (4) Institutions for education, health, sport, culture, and social welfare Public transportation, as defined by the implementing regulations. (5) Facilities for the production, processing, and packaging of food, beverages, and other goods for human consumption. (6) Warehouses, elevators, restrooms, and sites for the production. (7) Distribution, and refinement of petroleum, its derivatives, as well as gasoline and gas stations. (8) If these locations designate smoking zones, those areas must be separated, confined, and inaccessible to anyone who is younger than 18 years old (<xref ref-type="bibr" rid="B13">13</xref>).</p>
<p>Smoking is a significant risk factor for coronary artery disease in the Saudi population. Cigarette smoking is widespread among students of health care professionals; the study conducted in the College of Applied Medical Sciences in Riyadh, KSA reported 29% of respondents were current smokers (<xref ref-type="bibr" rid="B14">14</xref>). Diverse studies exhibited that smoking prevalence is relatively high among healthcare employees however they know the harmful effects of active and passive forms of smoking (<xref ref-type="bibr" rid="B7">7</xref>). Worldwide substantial predictors of smoking were found to be age, salary, peer pressure, family members, and academic performance (<xref ref-type="bibr" rid="B8">8</xref>). In addition, smoking habits in young adults were a potential predictor of smoking behavior in adulthood (<xref ref-type="bibr" rid="B9">9</xref>). Studies exhibited that smoking prevalence is moderately high among healthcare workers even though they know the harmful effects of active and passive smoking. A significant amount of work has been published on the predictors of smoking, but not specifically within the Saudi Arabia population. In specific, smoking by adolescents was a strong predictor of smoking behavior in young adults. Hence the present study is aimed to assess the prevalence of smoking habits among the students at KKU, Abha, KSA.</p>
</sec>
<sec sec-type="materials and methods" id="s2">
<title>2 Materials and methods</title>
<sec>
<title>2.1 Study site and sample size</title>
<p>A prospective cross-sectional study was conducted among KKU students. One thousand four hundred students approached and 731 responded with a completed questionnaire. Among those 731 questionnaires, eight due to insufficient data were excluded. Out of 723 respondents 365 were smokers and 358 were non-smokers. Three hundred sixty-five smokers was included in the present study. The participants were gathered using a snowball sampling technique.</p>
</sec>
<sec>
<title>2.2 Population criteria</title>
<p>Students of KKU who were willing to participate in the study voluntarily were included. Informed consent was obtained from the student participants who were willing to participate in the study, after explaining the project objectives. The study excluded those who did not provide their consent and had incomplete questionnaires.</p>
</sec>
<sec>
<title>2.3 Questionnaire</title>
<p>A well-structured, pre-validated nine self-administered online questionnaire (Google docs) was used. Students have responded to the modified Fagerstrom Tolerance questionnaire (mFTQ) in English. The responses were downloaded in an Excel sheet, which asks about their sociodemographic details, and social habits, especially tobacco consumption. The m FTQ is a widely used instrument to assess nicotine dependency (<xref ref-type="bibr" rid="B15">15</xref>). It consisted of seven questions related to the use of cigarettes, with scores ranging from 0 to 9. Question 1. &#x0201C;How many cigarettes a day do you smoke?&#x0201D; &#x0201C;2. Do you inhale?&#x0201D; &#x0201C;3. How soon after you wake up do you smoke your first cigarette?&#x0201D; &#x0201C;4. Which cigarette would you hate to give up?&#x0201D; &#x0201C;5. Do you find it difficult to refrain from smoking in places where it is forbidden (church, library, movies, etc.)?&#x0201D; &#x0201C;6. Do you smoke if you are so ill that you are in bed most of the day?&#x0201D; &#x0201C;7. Do you smoke more during the first 2 h than during the rest of the day?&#x0201D; All seven of the questions on this questionnaire use a five-point Likert scale, with the exception of the one about smoking during the first 2 h of the day. A score of mFTQ 0&#x02013;2 suggests no nicotine dependence, a score of 3&#x02013;5 suggests moderate dependence, and a score &#x02265;6 usually indicates high dependence (<xref ref-type="bibr" rid="B15">15</xref>). Additional question about willingness to quit smoking among current smokers was added. The validation of mFTQ with salivary cotinine among adolescents found that the mFTQ scale (<italic>r</italic> = 0.40) is valid and applicable to smokers of adolescents (<xref ref-type="bibr" rid="B16">16</xref>). The participants were asked if they had any thoughts of giving up smoking, and their yes/no responses were recorded. This study, REC No. 2018-06-42, HA-06-B-001 was exempted by the KKU ethics committee.</p>
</sec>
<sec>
<title>2.4 Statistical analysis</title>
<p>One thousand four hundred people were approached, and 731 returned the questionnaire with completed responses. Unfortunately, eight questions were disqualified because the data was not full. The sample characteristics were assessed using descriptive statistics. The significant relationship between the mFTQ variables was evaluated using the chi-square test. Statistical significance was set at <italic>p</italic> &#x0003C; 0.01.</p>
</sec>
</sec>
<sec sec-type="results" id="s3">
<title>3 Results</title>
<p>Among 365 smokers, 243 (67%) were male and 122 (33%) were female. The overall prevalence of current smokers in the study was 50.48% and 49.51% were non-smokers. The total prevalence of current daily smokers in the 18&#x02013;20 age group was 30% (<italic>n</italic> = 110), followed by 25% (<italic>n</italic> = 91), 25% (<italic>n</italic> = 91), 23% (<italic>n</italic> = 84), 10 (<italic>n</italic> = 37), and 12 (<italic>n</italic> = 43) in the 21&#x02013;22, 25&#x02013;30, and above 30 age groups. Details are given in <xref ref-type="table" rid="T1">Table 1</xref>.</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p>Age and gender wise distribution among the study population (<italic>n</italic> = 365).</p></caption>
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left"><bold>S. No</bold></th>
<th valign="top" align="center"><bold>Age</bold></th>
<th valign="top" align="center"><bold>Percentage (<italic>n</italic>)</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">1</td>
<td valign="top" align="center">18&#x02013;20</td>
<td valign="top" align="center">30 (110)</td>
</tr>
<tr>
<td valign="top" align="left">2</td>
<td valign="top" align="center">21&#x02013;22</td>
<td valign="top" align="center">25 (91)</td>
</tr>
<tr>
<td valign="top" align="left">3</td>
<td valign="top" align="center">23&#x02013;24</td>
<td valign="top" align="center">23 (84)</td>
</tr>
<tr>
<td valign="top" align="left">4</td>
<td valign="top" align="center">25&#x02013;30</td>
<td valign="top" align="center">10 (37)</td>
</tr>
<tr>
<td valign="top" align="left">5</td>
<td valign="top" align="center">Above 30</td>
<td valign="top" align="center">12 (43)</td>
</tr>
<tr style="background-color:#dee1e1">
<td valign="top" align="left" colspan="3"><bold>Gender</bold></td>
</tr>
<tr>
<td valign="top" align="left">7</td>
<td valign="top" align="center">Male</td>
<td valign="top" align="center">67 (243)</td>
</tr>
<tr>
<td valign="top" align="left">8</td>
<td valign="top" align="center">Female</td>
<td valign="top" align="center">33 (122)</td>
</tr></tbody>
</table>
</table-wrap>
<sec>
<title>3.1 Nicotine dependence</title>
<p>The scoring system of the mFTQ was used in the study. The percentage of respondents who indicated they were dependent on nicotine in response to particular questions is as follows. Several cigarette smoking in a day ranges: among the current smokers 56 (15%) were found to smoke over 26 cigarettes a day, 84 (23%) were found to smoke about 16&#x02013;25 cigarettes a day, 225 (62%) were found to smoke &#x0003C; 15 cigarettes a day. About 267 (73%) were found to inhale cigarette smoke always and 98 (27%) of smokers never inhaled cigarette smoke. A total of 157 (33%) participants said they smoke within the first 30 min of waking up, and 57% (208) said they smoke after awakening but before midday, and more than 30 min.</p>
<p>A total of 162 (44%) were found to dread giving up their first smoke of the day and 203 (56%) were found to give up any other cigarette in the afternoon. One hundred and eighty-one (180) respondents (49%) found it difficult to abstain from smoking when they were ill and spent the majority of the day in bed, and 61% (221) of smokers stated they find it difficult to stop from smoking in public areas where it is prohibited (Mosque, libraries, etc.). Also, 49% (180) of respondents were discovered to smoke more during the first 2 h of the day. Out of 365 smokers, 216 (59%) smokers were willing to quit and 149 (41%) smokers are not willing to quit. The details are given in <xref ref-type="table" rid="T2">Table 2</xref>. mFTQ (<italic>n</italic> = 365) scores of 0&#x02013;2 indicate no dependence, 3&#x02013;5 indicate moderate dependence, and &#x02265;6 indicate substantial dependence. Mean and standard deviation of no dependence 1.35 &#x000B1; 0.74, moderate dependence 3.91 &#x000B1; 0.81, substantial dependence 6.62 &#x000B1; 0.72. The number of current smokers in each category; no dependence, moderate dependence, and substance dependence were 121 (33%), 175 (48%), and 69 (19%) respectively. The details are given in <xref ref-type="table" rid="T3">Table 3</xref>.</p>
<table-wrap position="float" id="T2">
<label>Table 2</label>
<caption><p>Response to Modified Fagerstrom Tolerance Questionnaire (<italic>n</italic> = 365).</p></caption>
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left"><bold>S. No</bold></th>
<th valign="top" align="left"><bold>Modified Fagerstrom Questions (mFTQ)</bold></th>
<th valign="top" align="left"><bold>Responses</bold></th>
<th valign="top" align="left"><bold>Number (%)</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">1</td>
<td valign="top" align="left">Number of cigarettes smoking in a day</td>
<td valign="top" align="left">Over 26 cigarettes a day</td>
<td valign="top" align="left">56 (15)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">About 16&#x02013;25 cigarettes a day</td>
<td valign="top" align="left">84 (23)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">Less than 15 cigarettes a day</td>
<td valign="top" align="left">225 (62)</td>
</tr>
<tr>
<td valign="top" align="left">2</td>
<td valign="top" align="left">Inhalation of cigarette smoke</td>
<td valign="top" align="left">Always</td>
<td valign="top" align="left">267 (73)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">Never</td>
<td valign="top" align="left">98 (27)</td>
</tr>
<tr>
<td valign="top" align="left">3</td>
<td valign="top" align="left">First smoke on waking up</td>
<td valign="top" align="left">Within the first 30 min</td>
<td valign="top" align="left">157 (43)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">More than 30 min after waking but before noon</td>
<td valign="top" align="left">208 (57)</td>
</tr>
<tr>
<td valign="top" align="left">4</td>
<td valign="top" align="left">Cigarette would you hate to give up</td>
<td valign="top" align="left">First cigarette in the morning</td>
<td valign="top" align="left">162 (44)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">Any other cigarette in the afternoon</td>
<td valign="top" align="left">203 (56)</td>
</tr>
<tr>
<td valign="top" align="left">5</td>
<td valign="top" align="left">Difficult to refrain from smoking in public</td>
<td valign="top" align="left">Yes</td>
<td valign="top" align="left">221(61)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">No</td>
<td valign="top" align="left">144 (39)</td>
</tr>
<tr>
<td valign="top" align="left">6</td>
<td valign="top" align="left">Difficult to refrain from smoking when sick</td>
<td valign="top" align="left">Yes</td>
<td valign="top" align="left">180 (49)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">No</td>
<td valign="top" align="left">185 (51)</td>
</tr>
<tr>
<td valign="top" align="left">7</td>
<td valign="top" align="left">More smoking in first 2 h of the day</td>
<td valign="top" align="left">Yes</td>
<td valign="top" align="left">180 (49)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">No</td>
<td valign="top" align="left">185 (51)</td>
</tr>
<tr>
<td valign="top" align="left">8</td>
<td valign="top" align="left">Willingness to quit</td>
<td valign="top" align="left">Yes</td>
<td valign="top" align="left">216 (59)</td>
</tr>
 <tr>
<td/>
<td/>
<td valign="top" align="left">No</td>
<td valign="top" align="left">149 (41)</td>
</tr></tbody>
</table>
</table-wrap>
<table-wrap position="float" id="T3">
<label>Table 3</label>
<caption><p>Scores of Modified Version of the Fagerstrom Tolerance Questionnaire (mFTQ) (<italic>n</italic> = 365).</p></caption>
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left"><bold>S. No</bold></th>
<th valign="top" align="center"><bold>Scores</bold></th>
<th valign="top" align="center"><bold>Mean &#x000B1;SD</bold></th>
<th valign="top" align="center"><bold>Number of respondents (%)</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">1</td>
<td valign="top" align="center">0&#x02013;2 no dependence</td>
<td valign="top" align="center">1.35 &#x000B1; 0.74</td>
<td valign="top" align="center">121 (33)</td>
</tr>
<tr>
<td valign="top" align="left">2</td>
<td valign="top" align="center">3&#x02013;5 moderate dependence</td>
<td valign="top" align="center">3.91 &#x000B1; 0.81</td>
<td valign="top" align="center">175 (48)</td>
</tr>
<tr>
<td valign="top" align="left">3</td>
<td valign="top" align="center">&#x02265;6 substantial dependence</td>
<td valign="top" align="center">6.62 &#x000B1; 0.72</td>
<td valign="top" align="center">69 (19)</td>
</tr></tbody>
</table>
<table-wrap-foot>
<p>SD, standard deviation.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec>
<title>3.2 Nicotine dependence and variables of Modified Fagerstrom Tolerance Questionnaire (Chi Square Test)</title>
<p>Relationship between mFTQ and the number of cigarettes per day among the respondents (<italic>p</italic> &#x0003C; 0.001). Relationship between mFTQ score and first smoke of your cigarettes (<italic>p</italic> &#x0003C; 0.018). Relationship between mFTQ and smoke in the morning among the respondents (<italic>p</italic> &#x0003C; 0.007). Relationship between mFTQ and the difficulty refraining from smoking in public areas among the respondents (<italic>p</italic> &#x0003C; 0.000). Correlation between mFTQ and the cigarettes would you hate to give up among the respondents (<italic>p</italic> &#x0003C; 0.202). The details are given in <xref ref-type="table" rid="T4">Table 4</xref>.</p>
<table-wrap position="float" id="T4">
<label>Table 4</label>
<caption><p>Nicotine dependence and variables of Modified Fagerstrom Tolerance Questionnaire (mFTQ).</p></caption>
<table frame="box" rules="all">
<thead>
<tr style="background-color:#919498;color:#ffffff">
<th valign="top" align="left"><bold>S. No</bold></th>
<th valign="top" align="left"><bold>Variables</bold></th>
<th valign="top" align="center"><bold><italic>p</italic>-value</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">1</td>
<td valign="top" align="left">mFTQ score and number of cigarettes per day</td>
<td valign="top" align="center">0.001<sup>&#x0002A;</sup></td>
</tr>
<tr>
<td valign="top" align="left">2</td>
<td valign="top" align="left">mFTQ score and first smoke of your cigarettes</td>
<td valign="top" align="center">0.018<sup>&#x0002A;</sup></td>
</tr>
<tr>
<td valign="top" align="left">3</td>
<td valign="top" align="left">Do you smoke in the morning</td>
<td valign="top" align="center">0.007<sup>&#x0002A;</sup></td>
</tr>
<tr>
<td valign="top" align="left">4</td>
<td valign="top" align="left">Difficult to refrain smoking from public area</td>
<td valign="top" align="center">0.000<sup>&#x0002A;</sup></td>
</tr>
<tr>
<td valign="top" align="left">5</td>
<td valign="top" align="left">Cigarette would you hate give up</td>
<td valign="top" align="center">0.202</td>
</tr></tbody>
</table>
<table-wrap-foot>
<p><sup>&#x0002A;</sup>p &#x0003C; 0.01 is statistically significant.</p>
<p>Chi Square Test shows the association between the variables of questionnaire and Nicotine dependence among the study population.</p>
</table-wrap-foot>
</table-wrap></sec>
</sec>
<sec sec-type="discussion" id="s4">
<title>4 Discussion</title>
<p>Out of 723 total respondents, 365 respondents were found to be smokers and 358 were non-smokers. Among 365, 243 (67%) were male and 122 (33%) were female. The overall prevalence of current smokers in the study was 50.48%. Cigarette smoking is more predominant in Saudi males, the majority started smoking during their adolescent period and continued thereafter for many years (<xref ref-type="bibr" rid="B17">17</xref>). In addition, according to Wali&#x00027;s 2011 research, 9.1% of women and 24.8% of men smoke cigarettes (<xref ref-type="bibr" rid="B13">13</xref>).</p>
<p>Another study conducted in Saudi Arabia reported prevalence among male students was 30.4% (<xref ref-type="bibr" rid="B18">18</xref>). Moreover, a study on smoking rates among students at King Faisal University in Saudi Arabia found a similar prevalence of 28.1% (<xref ref-type="bibr" rid="B19">19</xref>). The prevalence of smoking among male students was high in the present study and female smokers are less compared to males. In the present study, among female students, 33% had recently used cigarettes, It is comparable to the research done to establish how the tobacco epidemic was spreading among female university students in Jeddah, Saudi Arabia&#x00027;s Western Region (<xref ref-type="bibr" rid="B20">20</xref>).</p>
<sec>
<title>4.1 Measurement of nicotine dependence</title>
<p>The study made use of the mFTQ scoring system. The proportion of respondents who responded favorably to particular questions about nicotine dependence. According to the study&#x00027;s findings, 62% of respondents smoked fewer than 15 cigarettes per day, 33% smoked between 16 and 25 cigarettes, and 15% smoked more than 26 cigarettes per day. This indicates the responders&#x00027; high level of nicotine dependence. Nicotine dependency is directly correlated with this high daily cigarette usage (<xref ref-type="bibr" rid="B21">21</xref>).</p>
<p>About 73% of respondents were found to inhale cigarette smoke always and 27% of smokers never inhaled cigarette smoke. In total, 43% of subjects admitted to smoking within the first 30 min of waking up, and 57% said they smoke before midday, more than 30 min after awakening. This could be attributed to the fact that the plasma nicotine levels are short and half-lived so it declines immediately after they wake up. This may be the reason that they are tempted to smoke early in the morning (<xref ref-type="bibr" rid="B22">22</xref>). Consequently, a morning cigarette urge is one of the signs of nicotine dependence as reported by Lamin et al. (<xref ref-type="bibr" rid="B23">23</xref>).</p>
<p>A total of 162 (44%) were found to many find it difficult to put up their morning cigarette, and 203 (56%) were found to give up any other cigarette in the afternoon. In the same way, 54.0% of smokers answered hate to give up the smoke during the first 2 h of the day (<xref ref-type="bibr" rid="B18">18</xref>). Sixty-one percentage (221) of smokers said that they find it difficult to refrain from smoking in public places where it is forbidden (Mosque, libraries, etc), 49% (180) of the respondents found it difficult to refrain from smoking when they are ill, they spend the majority of the day in bed, and 49% (180) of the respondents were found to more smoking in first 2 h of the day (<xref ref-type="bibr" rid="B24">24</xref>). Seventy percent of smokers reported that it is difficult not to smoke in forbidden areas like mosques and libraries. When severely ill (and spending the majority of the day in bed), those who were diagnosed as full smokers said they would smoke (<xref ref-type="bibr" rid="B25">25</xref>).</p>
<p>mFTQ (<italic>n</italic> = 365) scores of 0&#x02013;2 indicate no dependence, 3&#x02013;5 indicate moderate dependence, and &#x02265;6 indicate substantial dependence. Scores of no dependence, moderate dependence, and substance dependence were 121 (33%), 175 (48%), and 69 (19%), respectively. Similar results were reported by other studies that moderate nicotine dependence is high (<xref ref-type="bibr" rid="B26">26</xref>). Similar findings from earlier studies indicated that Thiruvananthapuram, Kerala&#x00027;s rural population had a high level of mild nicotine dependence (<xref ref-type="bibr" rid="B27">27</xref>). Another cross-sectional study revealed that among smokers, 34.4%, 39%, and 26.5% have no or mild, moderate, or severe nicotine dependency, respectively (<xref ref-type="bibr" rid="B28">28</xref>). According to a study conducted in Nepal, smokers with low degrees of nicotine dependence (<xref ref-type="bibr" rid="B4">4</xref>) had nicotine levels of 70.2%, medium (<xref ref-type="bibr" rid="B4">4</xref>&#x02013;<xref ref-type="bibr" rid="B6">6</xref>), 52.8%, and high (<xref ref-type="bibr" rid="B7">7</xref>&#x02013;<xref ref-type="bibr" rid="B10">10</xref>), 12.0% (<xref ref-type="bibr" rid="B29">29</xref>).</p>
</sec>
<sec>
<title>4.2 Nicotine dependence and variables of Modified Fagerstrom Tolerance Questionnaire (Chi Square Test)</title>
<p>From the study outcomes, there was a strong correlation found between mFTQ scores and the number of cigarettes per day, mFTQ scores and first smoke of cigarettes, mFTQ scores and smoking habit in the morning, mFTQ scores and difficulty to refrain smoke from public areas. The findings of the present study explain that the higher number of cigarettes per day has a significant association with the mFTQ scores (<xref ref-type="bibr" rid="B23">23</xref>). Previous study shown that the mFTQ score often increased as the severity of the smoking is increased due to a strong linear connection between the two variables (<italic>p</italic> &#x0003C; 0.001) (<xref ref-type="bibr" rid="B25">25</xref>).</p>
</sec>
<sec>
<title>4.3 Quitting behavior</title>
<p>Out of 365, 216 (59%) smokers were willing to quit and 149 (41%) smokers are not willing to quit. This shows that college students in the KSA may be aware of the advantages of quitting smoking, and that in the future, effective education initiatives will be required to support them. This result is congruent with those of Majmaah University KSA where 71.8 percent of smokers in college had previously tried to give up smoking (<xref ref-type="bibr" rid="B18">18</xref>). Another study conducted in KSA revealed that 65% of smokers were ready to give up the habit (<xref ref-type="bibr" rid="B30">30</xref>). According to other studies, the majority of smokers had made at least one attempt to stop smoking (<xref ref-type="bibr" rid="B31">31</xref>). The readiness to give up smoking among patients in all categories, including those with mild, moderate, and severe nicotine dependence (<xref ref-type="bibr" rid="B28">28</xref>). After receiving smoking cessation education in schools, knowledge and attitudes about smoking harm prevention considerably improved. Numerous research have shown this improvement in awareness and attitudes toward smoking harm prevention. The organization plan activities that can improve the physical fitness and cardiopulmonary endurance of outpatients who are quitting smoking in clinics, as well as a series of smoking cessation education and training sessions (<xref ref-type="bibr" rid="B32">32</xref>).</p>
<p>The high prevalence of tobacco use and the affirmative responses provided by respondents who were smokers to the Fagerstrom questions suggest that tobacco use is becoming a serious issue in universities. The ambitious tobacco control initiatives developed by the health ministry must be implemented locally. The strict enforcement of the laws adopted with that purpose and a reduction in the supply and demand for tobacco products should be the objectives of the policies (<xref ref-type="bibr" rid="B33">33</xref>, <xref ref-type="bibr" rid="B34">34</xref>) and antismoking programs.</p>
</sec>
<sec>
<title>4.4 Limitations</title>
<p>This type of cross-sectional study has limitations, including recall bias. Moreover, the study&#x00027;s generalizability may be limited because its participants were college students from a single public university.</p>
</sec>
</sec>
<sec sec-type="conclusions" id="s5">
<title>5 Conclusion</title>
<p>Almost 50% of smokers in this study had a moderate level of dependency. Overall, 59% of smokers expressed a willingness or intention to stop smoking. The present study concludes that the prevalence of smoking habits in males was relatively high. Women were less likely than men to smoke every day. In this study, around 50 % of smokers were moderately dependence. It raises the alarm about the critical need for adequate education to support health education initiatives, discourage teen smoking, and enhance health outcomes for the community. To make sure that tobacco control measures are effective and efficient, university anti-smoking policies should be evaluated on a regular basis. In addition, we require programs for quitting smoking, health promotion, and education about the adverse effects of smoking.</p>
</sec>
<sec sec-type="data-availability" id="s6">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec sec-type="ethics-statement" id="s7">
<title>Ethics statement</title>
<p>This study, REC No. 2018-06-42, HA-06-B-001 was exempted by the KKU Ethics Committee. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.</p>
</sec>
<sec sec-type="author-contributions" id="s8">
<title>Author contributions</title>
<p>GK: Conceptualization, Data curation, Funding acquisition, Methodology, Writing &#x02013; original draft, Writing &#x02013; review &#x00026; editing. GS: Writing &#x02013; review &#x00026; editing, Data curation, Methodology, Supervision. MA: Writing &#x02013; review &#x00026; editing, Conceptualization, Formal analysis, Investigation, Software. TA: Formal analysis, Project administration, Validation, Writing &#x02013; review &#x00026; editing. ES: Resources, Software, Validation, Visualization, Writing &#x02013; review &#x00026; editing. AMA: Project administration, Writing &#x02013; review &#x00026; editing. RA: Project administration, Validation, Writing &#x02013; review &#x00026; editing. AH: Formal analysis, Writing &#x02013; review &#x00026; editing. AYA: Data curation, Supervision, Writing &#x02013; review &#x00026; editing. KP: Supervision, Writing &#x02013; review &#x00026; editing. VV: Methodology, Writing &#x02013; review &#x00026; editing. PA: Formal analysis, Validation, Writing &#x02013; review &#x00026; editing. BM: Conceptualization, Data curation, Methodology, Writing &#x02013; review &#x00026; editing. VM: Conceptualization, Data curation, Project administration, Software, Supervision, Validation, Writing &#x02013; original draft.</p>
</sec>
</body>
<back>
<sec sec-type="funding-information" id="s9">
<title>Funding</title>
<p>The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors extend their appreciation to the Deanship of Scientific Research at KKU for funding this work through large group Research Project under grant number RGP2/150/44.</p>
</sec>
<ack><p>The authors extend their appreciation to the Deanship of Scientific Research at KKU for funding this work through large group Research Project.</p>
</ack>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s10">
<title>Publisher&#x00027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<ref-list>
<title>References</title>
<ref id="B1">
<label>1.</label>
<citation citation-type="web"><person-group person-group-type="author"><collab>WHO</collab></person-group> (<year>2011</year>). <source>WHO Report on the Global Tobacco Epidemic 2011: Warning about the Dangers of Tobacco</source>. <publisher-loc>WHO. UCSF</publisher-loc>: <publisher-name>Center for Tobacco Control Research and Education</publisher-name>. Available online at: <ext-link ext-link-type="uri" xlink:href="https://escholarship.org/uc/item/5np8p434">https://escholarship.org/uc/item/5np8p434</ext-link></citation>
</ref>
<ref id="B2">
<label>2.</label>
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Drope</surname> <given-names>J</given-names></name> <name><surname>Schluger</surname> <given-names>N</given-names></name> <name><surname>Cahn</surname> <given-names>Z</given-names></name> <name><surname>Drope</surname> <given-names>J</given-names></name> <name><surname>Hamill</surname> <given-names>S</given-names></name> <name><surname>Islami</surname> <given-names>F</given-names></name> <etal/></person-group>. <source>The Tobacco Atlas</source>, <edition>6th ed</edition>. <publisher-loc>Atlanta, GA</publisher-loc>: <publisher-name>American Cancer Society, Vital Strategies</publisher-name> (<year>2018</year>).</citation>
</ref>
<ref id="B3">
<label>3.</label>
<citation citation-type="web"><person-group person-group-type="author"><collab>Centers for Disease Control and Prevention Global Tobacco Control</collab></person-group>. Available online at: <ext-link ext-link-type="uri" xlink:href="https://www.cdc.gov/tobacco/global/index.htm">https://www.cdc.gov/tobacco/global/index.htm</ext-link> (accessed August 15, 2018).</citation>
</ref>
<ref id="B4">
<label>4.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ng</surname> <given-names>M</given-names></name> <name><surname>Freeman</surname> <given-names>MK</given-names></name> <name><surname>Fleming</surname> <given-names>TD</given-names></name> <name><surname>Robinson</surname> <given-names>M</given-names></name> <name><surname>Dwyer-Lindgren</surname> <given-names>L</given-names></name> <name><surname>Thomson</surname> <given-names>B</given-names></name> <etal/></person-group>. <article-title>Smoking prevalence and cigarette consumption in 187 countries, 1980-2012</article-title>. <source>JAMA.</source> (<year>2014</year>) <volume>311</volume>:<fpage>183</fpage>&#x02013;<lpage>92</lpage>. <pub-id pub-id-type="doi">10.1001/jama.2013.284692</pub-id><pub-id pub-id-type="pmid">24399557</pub-id></citation></ref>
<ref id="B5">
<label>5.</label>
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Taha</surname> <given-names>S</given-names></name></person-group>. <article-title>KSA imports tobacco products worth SR13 billion in 4 years</article-title>. <source>Arab News</source>. (<year>2014</year>). Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.arabnews.com/news/saudi-arabia/614961">http://www.arabnews.com/news/saudi-arabia/614961</ext-link> (accessed August 20, 2018).</citation>
</ref>
<ref id="B6">
<label>6.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>AlBedah</surname> <given-names>AM</given-names></name> <name><surname>Khalil</surname> <given-names>MK</given-names></name></person-group>. <article-title>The economic costs of tobacco consumption in the Kingdom of Saudi Arabia</article-title>. <source>Tob Control.</source> (<year>2014</year>) <volume>23</volume>:<fpage>434</fpage>&#x02013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1136/tobaccocontrol-2012-050665</pub-id><pub-id pub-id-type="pmid">23696558</pub-id></citation></ref>
<ref id="B7">
<label>7.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Siddiqui</surname> <given-names>S</given-names></name> <name><surname>Ogbeide</surname> <given-names>D</given-names></name></person-group>. <article-title>Profile of smoking amongst health staff in a primary care unit at a general hospital in Riyadh, Saudi Arabia</article-title>. <source>Saudi Med J.</source> (<year>2014</year>) <volume>22</volume>:<fpage>1101</fpage>&#x02013;<lpage>4</lpage>.<pub-id pub-id-type="pmid">11802185</pub-id></citation></ref>
<ref id="B8">
<label>8.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Murthy</surname> <given-names>P</given-names></name> <name><surname>Subodh</surname> <given-names>BN</given-names></name></person-group>. <article-title>Current developments in behavioural interventions for tobacco cessation</article-title>. <source>Curr Opin Psychiatry.</source> (<year>2010</year>) <volume>23</volume>:<fpage>151</fpage>&#x02013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1097/YCO.0b013e328336653f</pub-id></citation>
</ref>
<ref id="B9">
<label>9.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Weekley</surname> <given-names>CK</given-names></name> <name><surname>Klesges</surname> <given-names>RC</given-names></name> <name><surname>Reylea</surname> <given-names>G</given-names></name></person-group>. <article-title>Smoking as a weight control strategy and its relationship to smoking status</article-title>. <source>Addict Behav.</source> (<year>1992</year>) <volume>17</volume>:<fpage>259</fpage>&#x02013;<lpage>71</lpage>. <pub-id pub-id-type="doi">10.1016/0306-4603(92)90031-P</pub-id><pub-id pub-id-type="pmid">1636473</pub-id></citation></ref>
<ref id="B10">
<label>10.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Al-Bedha</surname> <given-names>AM</given-names></name> <name><surname>Qureshi</surname> <given-names>NA</given-names></name> <name><surname>Al-Guhaimani</surname> <given-names>HI</given-names></name> <name><surname>Basahi</surname> <given-names>JA</given-names></name></person-group>. <article-title>The global youth tobacco survey-2007. Comparison with the global youth tobacco survey 2001-2002 in Saudi Arabia</article-title>. <source>Saudi Med J</source>. (<year>2010</year>) <volume>31</volume>:<fpage>1036</fpage>&#x02013;<lpage>43</lpage>.<pub-id pub-id-type="pmid">20844818</pub-id></citation></ref>
<ref id="B11">
<label>11.</label>
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Bonnie</surname> <given-names>RJ</given-names></name> <name><surname>Stratton</surname> <given-names>K</given-names></name> <name><surname>Kwan</surname> <given-names>LY</given-names></name> <name><surname>editors</surname></name></person-group>. <source>Public Health Implications of Raising the Minimum Age of Legal Access to Tobacco Products</source>. <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>National Academies Press (US)</publisher-name> (<year>2015</year>). <pub-id pub-id-type="doi">10.17226/18997</pub-id><pub-id pub-id-type="pmid">26269869</pub-id></citation></ref>
<ref id="B12">
<label>12.</label>
<citation citation-type="web"><person-group person-group-type="author"><collab>World Health Organization</collab></person-group>. <source>Smoking Statistics, Fact Sheet 2002, WHO, Regional Office or the Western Pacific 2005</source>. Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/en/">http://www.who.int/en/</ext-link> (accessed September 22, 2019).</citation>
</ref>
<ref id="B13">
<label>13.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wali</surname> <given-names>SO</given-names></name></person-group>. <article-title>Smoking habits among medical students in Western Saudi Arabia</article-title>. <source>Saudi Med J.</source> (<year>2011</year>) <volume>32</volume>:<fpage>843</fpage>&#x02013;<lpage>8</lpage>.</citation>
</ref>
<ref id="B14">
<label>14.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lamkin</surname> <given-names>L</given-names></name> <name><surname>Houston</surname> <given-names>TP</given-names></name></person-group>. <article-title>Nicotine dependency and adolescents: preventing and treating</article-title>. <source>Prim Care.</source> (<year>2015</year>) <volume>25</volume>:<fpage>123</fpage>&#x02013;<lpage>35</lpage>. <pub-id pub-id-type="doi">10.1016/S0095-4543(05)70328-6</pub-id><pub-id pub-id-type="pmid">9469919</pub-id></citation></ref>
<ref id="B15">
<label>15.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Prokhorov</surname> <given-names>AV</given-names></name> <name><surname>Koehly</surname> <given-names>LM</given-names></name> <name><surname>Pallonen</surname> <given-names>UE</given-names></name></person-group>. <article-title>Adolescent nicotine dependence measured by the Modified Fagerstrom Tolerance Questionnaire at two time points</article-title>. <source>J Child Adolesc Subst Abuse.</source> (<year>1998</year>) <volume>7</volume>:<fpage>35</fpage>&#x02013;<lpage>47</lpage>. <pub-id pub-id-type="doi">10.1300/J029v07n04_03</pub-id></citation>
</ref>
<ref id="B16">
<label>16.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Prokhorov</surname> <given-names>AV</given-names></name> <name><surname>De Moor</surname> <given-names>C</given-names></name> <name><surname>Pallonen</surname> <given-names>UE</given-names></name> <name><surname>Hudmon</surname> <given-names>KS</given-names></name> <name><surname>Koehly</surname> <given-names>L</given-names></name> <name><surname>Hu</surname> <given-names>S</given-names></name></person-group>. <article-title>Validation of the modified Fagerstrom tolerance questionnaire with salivary cotinine among adolescents</article-title>. <source>Addict Behav.</source> (<year>2000</year>) <volume>25</volume>:<fpage>429</fpage>&#x02013;<lpage>33</lpage>. <pub-id pub-id-type="doi">10.1016/S0306-4603(98)00132-4</pub-id><pub-id pub-id-type="pmid">10890296</pub-id></citation></ref>
<ref id="B17">
<label>17.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Saeed</surname> <given-names>AAW</given-names></name> <name><surname>Khoja</surname> <given-names>TA</given-names></name> <name><surname>Khan</surname> <given-names>SB</given-names></name></person-group>. <article-title>Smoking behaviours and attitudes among adult Saudi nationals in Riyadh city, Saudi Arabia</article-title>. <source>Tob Control</source>. (<year>1996</year>) <volume>5</volume>:<fpage>215</fpage>&#x02013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1136/tc.5.3.215</pub-id><pub-id pub-id-type="pmid">9035357</pub-id></citation></ref>
<ref id="B18">
<label>18.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Al-Ghaneem</surname> <given-names>SG</given-names></name> <name><surname>Al-Mansour</surname> <given-names>AA</given-names></name> <name><surname>Mohamed</surname> <given-names>EY</given-names></name> <name><surname>Rizvi</surname> <given-names>M</given-names></name> <name><surname>Al-Nefisah</surname> <given-names>OS</given-names></name></person-group>. <article-title>The prevalence of smoking among male students of Majmaah University, KSA</article-title>. <source>J Taibha Univ Med Sci.</source> (<year>2016</year>) <volume>11</volume>:<fpage>175</fpage>&#x02013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1016/j.jtumed.2016.01.006</pub-id></citation>
</ref>
<ref id="B19">
<label>19.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Al-Mohamed</surname> <given-names>HI</given-names></name> <name><surname>Amin</surname> <given-names>TT</given-names></name></person-group>. <article-title>Pattern and prevalence of smoking among students at King Faisal University, Al Hassa, Saudi Arabia</article-title>. <source>East Mediterr Health J</source>. (<year>2010</year>) <volume>16</volume>:<fpage>56</fpage>&#x02013;<lpage>64</lpage>. <pub-id pub-id-type="doi">10.26719/2010.16.1.56</pub-id><pub-id pub-id-type="pmid">20214159</pub-id></citation></ref>
<ref id="B20">
<label>20.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Warren</surname> <given-names>CW</given-names></name> <name><surname>Jones</surname> <given-names>NR</given-names></name> <name><surname>Eriksen</surname> <given-names>MP</given-names></name> <name><surname>Asma</surname> <given-names>S</given-names></name></person-group>. <article-title>Global tobacco surveillance system (GTSS) collaborative group</article-title>. <source>Lancet.</source> (<year>2006</year>) <volume>367</volume>:<fpage>749</fpage>&#x02013;<lpage>53</lpage>. <pub-id pub-id-type="doi">10.1016/S0140-6736(06)68192-0</pub-id></citation>
</ref>
<ref id="B21">
<label>21.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Weber</surname> <given-names>CF</given-names></name> <name><surname>Hatschbach</surname> <given-names>P</given-names></name> <name><surname>Pithan</surname> <given-names>SA</given-names></name> <name><surname>Dos Santos Dullius</surname> <given-names>AI</given-names></name></person-group>. <article-title>Measure nicotine dependence by the Fagerstrom test for nicotine dependence</article-title>. <source>Rev Gauch Odontol</source>. (<year>2017</year>) <volume>65</volume>:<fpage>208</fpage>&#x02013;<lpage>15</lpage>. <pub-id pub-id-type="doi">10.1590/1981-863720170002000043223</pub-id></citation>
</ref>
<ref id="B22">
<label>22.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Haberstick</surname> <given-names>BC</given-names></name> <name><surname>Timberlake</surname> <given-names>D</given-names></name> <name><surname>Ehringer</surname> <given-names>MA</given-names></name> <name><surname>Lessem</surname> <given-names>JM</given-names></name> <name><surname>Hopfer</surname> <given-names>CJ</given-names></name> <name><surname>Smolen</surname> <given-names>A</given-names></name> <etal/></person-group>. <article-title>Genes, time to first cigarette and nicotine dependence in a general population sample of young adults</article-title>. <source>Addiction.</source> (<year>2007</year>) <volume>102</volume>:<fpage>655</fpage>&#x02013;<lpage>65</lpage>. <pub-id pub-id-type="doi">10.1111/j.1360-0443.2007.01746.x</pub-id><pub-id pub-id-type="pmid">17309537</pub-id></citation></ref>
<ref id="B23">
<label>23.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lamin</surname> <given-names>RAC</given-names></name> <name><surname>Othman</surname> <given-names>N</given-names></name> <name><surname>Othman</surname> <given-names>CN</given-names></name></person-group>. <article-title>Effect of smoking behaviour on nicotine dependence level among adolescents</article-title>. <source>Procedia Soc Behav Sci</source>. (<year>2014</year>) <volume>153</volume>:<fpage>189</fpage>&#x02013;<lpage>98</lpage>. <pub-id pub-id-type="doi">10.1016/j.sbspro.2014.10.053</pub-id></citation>
</ref>
<ref id="B24">
<label>24.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kandel</surname> <given-names>D</given-names></name> <name><surname>Schaffran</surname> <given-names>C</given-names></name> <name><surname>Griesler</surname> <given-names>P</given-names></name> <name><surname>Samuolis</surname> <given-names>J</given-names></name> <name><surname>Davies</surname> <given-names>M</given-names></name> <name><surname>Galanti</surname> <given-names>R</given-names></name></person-group>. <article-title>On the measurement of nicotine dependence in adolescence: comparisons of the mFTQ and a DSM-IV&#x02013;based scale</article-title>. <source>J Pediatr Psychol</source>. (<year>2005</year>) <volume>30</volume>:<fpage>319</fpage>&#x02013;<lpage>32</lpage>. <pub-id pub-id-type="doi">10.1093/jpepsy/jsi027</pub-id><pub-id pub-id-type="pmid">15863429</pub-id></citation></ref>
<ref id="B25">
<label>25.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wilens</surname> <given-names>TE</given-names></name> <name><surname>Vitulano</surname> <given-names>M</given-names></name> <name><surname>Upadhyaya</surname> <given-names>H</given-names></name> <name><surname>Adamson</surname> <given-names>J</given-names></name> <name><surname>Parcell</surname> <given-names>T</given-names></name> <name><surname>Westerberg</surname> <given-names>D</given-names></name> <etal/></person-group>. <article-title>Concordance between cigarette smoking and the modified Fagerstrom tolerance questionnaire in controlled studies Of ADHD</article-title>. <source>Am J addict.</source> (<year>2008</year>) <volume>17</volume>:<fpage>491</fpage>&#x02013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1080/10550490802409082</pub-id><pub-id pub-id-type="pmid">19034741</pub-id></citation></ref>
<ref id="B26">
<label>26.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pascol</surname> <given-names>IO</given-names></name> <name><surname>Trofor</surname> <given-names>L</given-names></name> <name><surname>Christia</surname> <given-names>R</given-names></name> <name><surname>Miron</surname> <given-names>R</given-names></name> <name><surname>Trofor</surname> <given-names>A</given-names></name></person-group>. <article-title>Addiction to nicotine in moderate smokers &#x02013; clinical profile and smoking cessation outcomes</article-title>. <source>Rom J Oral Rehabil</source>. (<year>2015</year>) <volume>7</volume>:<fpage>62</fpage>&#x02013;<lpage>7</lpage>.</citation>
</ref>
<ref id="B27">
<label>27.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Aleyamma Mathew</surname> <given-names>JR</given-names></name> <name><surname>Lekshmi</surname> <given-names>K</given-names></name> <name><surname>Sebastian</surname> <given-names>P</given-names></name> <name><surname>Finne</surname> <given-names>P</given-names></name> <name><surname>Uutela</surname> <given-names>A</given-names></name></person-group>. <article-title>Assessment of nicotine dependence among smokers in a selected rural population in Kerala, India</article-title>. <source>Asian Pac J Cancer Prev.</source> (<year>2016</year>) <volume>13</volume>:<fpage>2663</fpage>&#x02013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.7314/APJCP.2012.13.6.2663</pub-id><pub-id pub-id-type="pmid">22938438</pub-id></citation></ref>
<ref id="B28">
<label>28.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Li</surname> <given-names>L</given-names></name> <name><surname>Li</surname> <given-names>H</given-names></name> <name><surname>Zhang</surname> <given-names>Y</given-names></name> <name><surname>Zheng</surname> <given-names>C</given-names></name> <name><surname>Xu</surname> <given-names>H</given-names></name> <name><surname>Cheng</surname> <given-names>Z</given-names></name></person-group>. <article-title>Exploring the degree of nicotine dependence and willingness to quit smoking in Chinese smoking patients with stroke: a cross-sectional survey</article-title>. <source>Medicine.</source> (<year>2021</year>) <volume>100</volume>:<fpage>e27715</fpage>. <pub-id pub-id-type="doi">10.1097/MD.0000000000027715</pub-id><pub-id pub-id-type="pmid">34889222</pub-id></citation></ref>
<ref id="B29">
<label>29.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Subedi</surname> <given-names>K</given-names></name> <name><surname>Shrestha</surname> <given-names>A</given-names></name> <name><surname>Bhagat</surname> <given-names>T</given-names></name></person-group>. <article-title>Assessment of nicotine dependence among tobacco users visiting outreach programs in Dharan, Nepal: a cross-sectional study</article-title>. <source>BMC Public Health</source>. (<year>2021</year>) <volume>21</volume>:<fpage>1515</fpage>. <pub-id pub-id-type="doi">10.1186/s12889-021-11535-9</pub-id><pub-id pub-id-type="pmid">34362327</pub-id></citation></ref>
<ref id="B30">
<label>30.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Almogbel</surname> <given-names>YS</given-names></name> <name><surname>Abughosh</surname> <given-names>SM</given-names></name> <name><surname>Almeman</surname> <given-names>AA</given-names></name> <name><surname>Sansgiry</surname> <given-names>SS</given-names></name></person-group>. <article-title>Factors associated with the willingness to quit smoking among a cohort of university students in the KSA</article-title>. <source>J Taibah Univ Sci</source>. (<year>2016</year>) <volume>11</volume>:<fpage>128</fpage>.e133. <pub-id pub-id-type="doi">10.1016/j.jtumed.2016.01.004</pub-id></citation>
</ref>
<ref id="B31">
<label>31.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Coppo</surname> <given-names>A</given-names></name> <name><surname>Baldissera</surname> <given-names>S</given-names></name> <name><surname>Migliardi</surname> <given-names>A</given-names></name> <name><surname>Minardi</surname> <given-names>V</given-names></name> <name><surname>Quarchioni</surname> <given-names>E</given-names></name> <name><surname>Ferrante</surname> <given-names>G</given-names></name> <etal/></person-group>. <article-title>Quit attempts and smoking cessation in Italian adults (25-64 years): factors associated with attempts and successes</article-title>. <source>Eur J Public Health.</source> (<year>2017</year>) <volume>27</volume>:<fpage>717</fpage>&#x02013;<lpage>22</lpage>. <pub-id pub-id-type="doi">10.1093/eurpub/ckw262</pub-id><pub-id pub-id-type="pmid">28108591</pub-id></citation></ref>
<ref id="B32">
<label>32.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Odukoya</surname> <given-names>OO</given-names></name> <name><surname>Odeyemi</surname> <given-names>KA</given-names></name> <name><surname>Oyeyemi</surname> <given-names>AS</given-names></name> <name><surname>Upadhyay</surname> <given-names>RP</given-names></name></person-group>. <article-title>The effect of a short anti-smoking awareness programme on the knowledge, attitude and practice of cigarette smoking among secondary school students in Lagos state, Nigeria</article-title>. <source>Niger Postgrad Med J.</source> (<year>2014</year>) <volume>21</volume>:<fpage>128</fpage>. <pub-id pub-id-type="doi">10.4103/1117-1936.163607</pub-id><pub-id pub-id-type="pmid">25126866</pub-id></citation></ref>
<ref id="B33">
<label>33.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mathew</surname> <given-names>P</given-names></name> <name><surname>Indiradevi</surname> <given-names>ER</given-names></name> <name><surname>Srijith</surname> <given-names>R</given-names></name> <name><surname>Mathew</surname> <given-names>T</given-names></name> <name><surname>Varghese</surname> <given-names>V</given-names></name> <name><surname>Vijayan</surname> <given-names>V</given-names></name></person-group>. <article-title>Prevalence and risk factors for tobacco smoking, among college students of South India</article-title>. <source>Int J Health Sci</source>. (<year>2014</year>) <volume>2</volume>:<fpage>354</fpage>&#x02013;<lpage>7</lpage>.</citation>
</ref>
<ref id="B34">
<label>34.</label>
<citation citation-type="book"><person-group person-group-type="author"><name><surname>Khoja</surname> <given-names>T</given-names></name> <name><surname>Farid</surname> <given-names>S</given-names></name></person-group>. <source>Saudi Arabia Family Health Survey</source>. <publisher-loc>Riyadh</publisher-loc>: <publisher-name>Council of Health Ministries of GCC States</publisher-name> (<year>2000</year>).</citation>
</ref>
</ref-list>
</back>
</article>