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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
<issn pub-type="epub">2296-2565</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2023.1106206</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health</subject>
<subj-group>
<subject>Systematic Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Effectiveness of multilevel interventions based on socio-ecological model to decrease sedentary time in children: a systematic review of controlled studies</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Cholley-Gomez</surname> <given-names>Marie</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1858625/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Laujac</surname> <given-names>Steven</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Delpierre</surname> <given-names>Cyrille</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/541045/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Carayol</surname> <given-names>Marion</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/2050597/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>IAPS Laboratory &#x0201C;Impact of Physical Activity on Health&#x0201D;, University of Toulon</institution>, <addr-line>Toulon</addr-line>, <country>France</country></aff>
<aff id="aff2"><sup>2</sup><institution>ACTES Laboratory, University of Antilles</institution>, <addr-line>Pointe-&#x000E0;-Pitre</addr-line>, <country>Guadeloupe</country></aff>
<aff id="aff3"><sup>3</sup><institution>Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer, H&#x000F4;pital Sainte Musse</institution>, <addr-line>Toulon</addr-line>, <country>France</country></aff>
<aff id="aff4"><sup>4</sup><institution>EQUITY Team, CERPOP UMR 1295, Inserm-Universit&#x000E9; Toulouse III</institution>, <addr-line>Toulouse</addr-line>, <country>France</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Mirko Brandes, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Germany</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Sitong Chen, Victoria University, Australia; Birgit Sperlich, Julius Maximilian University of W&#x000FC;rzburg, Germany</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Marie Cholley-Gomez <email>marie.cholleygomez&#x00040;hotmail.fr</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>02</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>11</volume>
<elocation-id>1106206</elocation-id>
<history>
<date date-type="received">
<day>23</day>
<month>11</month>
<year>2022</year>
</date>
<date date-type="accepted">
<day>08</day>
<month>05</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2023 Cholley-Gomez, Laujac, Delpierre and Carayol.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Cholley-Gomez, Laujac, Delpierre and Carayol</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<sec>
<title>Objectives</title>
<p>Preventive actions of sedentary behavior (SB) based on the socio-ecological model are needed among children and young adolescents. The aim of this systematic review is to ascertain the effectiveness of multilevel interventions (i.e., involving consideration of at least two interventional levels) in reducing sedentary time (ST) in children aged 5&#x02013;12 years.</p>
</sec>
<sec>
<title>Methods</title>
<p>Adhering to PRISMA guidelines, a systematic literature search was conducted in three databases (PsyInfo, PubMed and ERIC) until July 2021.</p>
</sec>
<sec>
<title>Results</title>
<p>30 trials met the eligibility criteria and were included. They showed acceptable (&#x0003C; 8, <italic>n</italic> = 18) and high (&#x02265; 8, <italic>n</italic> = 12) methodological quality. Among studies targeting 2 (<italic>n</italic> = 2), 3 (<italic>n</italic> = 19) and 4 levels (<italic>n</italic> = 9), 1 (50%), 9 (47%) and 7 (78%) were effective and reported significant reduction of ST, respectively.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Interventions tend to be more effective when they involve 4 levels, using both agentic and structural strategies (targeting intrinsic determinants, in the organizational environment of the child). Findings underline the relevance of multilevel strategies to reduce ST in children, but also raise issues about operationalization of the socio-ecological perspective.</p>
</sec>
<sec>
<title>Systematic review registration</title>
<p>PROSPERO, identifier: CRD42020209653.</p>
</sec>
</abstract>
<kwd-group>
<kwd>sedentary</kwd>
<kwd>intervention</kwd>
<kwd>prevention</kwd>
<kwd>socio-ecologic</kwd>
<kwd>multilevel</kwd>
</kwd-group>
<contract-sponsor id="cn001">Institut National Du Cancer<named-content content-type="fundref-id">10.13039/501100006364</named-content></contract-sponsor>
<counts>
<fig-count count="2"/>
<table-count count="3"/>
<equation-count count="0"/>
<ref-count count="93"/>
<page-count count="26"/>
<word-count count="14372"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Children and Health</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="s1">
<title>Introduction</title>
<sec>
<title>Sedentary behavior in young populations: an increasing public health concern</title>
<p>Sedentary lifestyle or sedentary behavior (SB) refers to &#x0201C;any waking behavior characterized by an energy expenditure &#x02264;1.5 metabolic equivalents (METs)&#x0201D; (<xref ref-type="bibr" rid="B1">1</xref>), such as reading, watching TV, or working on a computer. Among SB, &#x0201C;screen-related&#x0201D; SB (<xref ref-type="bibr" rid="B2">2</xref>) are particularly worrying this last decade. Indeed, Sedentary Time (ST) has been associated with poorer health outcomes in children (<xref ref-type="bibr" rid="B3">3</xref>, <xref ref-type="bibr" rid="B4">4</xref>).</p>
<p>However, a significant part of children and young adolescents does not reach active lifestyle recommendations (<xref ref-type="bibr" rid="B5">5</xref>): SB (i.e., &#x02265;4 h 30 min of daily sitting time) was identified in 76.8% of European adolescents in 2017 with no differences between girls and boys (<xref ref-type="bibr" rid="B6">6</xref>), and over the world, 81% of adolescents aged 11&#x02013;17 years were insufficiently physically active in 2016 (<xref ref-type="bibr" rid="B7">7</xref>). In France, national surveys showed that screen-time increases with age: more than 50% of school-aged children (6&#x02013;10 years) spent at least 3 h/day [ESTEBAN 2014&#x02013;2016 survey, see Balicco et al., (<xref ref-type="bibr" rid="B8">8</xref>)]; and between 2007 and 2015 [Inca2, 2007, and Inca3, 2015, see Dubuisson et al. (<xref ref-type="bibr" rid="B9">9</xref>)], screen time was increased by 20 min on average.</p>
</sec>
<sec>
<title>The socio-ecological approach of sedentary behavior</title>
<p>There is a great demand in research for addressing public health issues by focusing on structural social determinants, particularly within the field of PA and sedentary lifestyle (<xref ref-type="bibr" rid="B10">10</xref>&#x02013;<xref ref-type="bibr" rid="B14">14</xref>).</p>
<p>The socio-ecological model, based on the original work of McLeroy et al. (<xref ref-type="bibr" rid="B15">15</xref>) provides a useful comprehensive framework for this purpose. It marks a break with the cognitive behavioral-based approaches, by considering the social mechanisms of the production of health issues (<xref ref-type="bibr" rid="B16">16</xref>). The visual metaphor is a series of concentric circles representing different levels of influence on behavior. With a reciprocal determinism, each environmental level contains multiple types of environments (i.e., social, physical) and is in interaction with others.</p>
<p>Applied to the determinants of SB, this multifactorial approach states that these behaviors can be influenced by a multiplicity of levels, from the most proximal to the broader settings: intrapersonal [Psychological (e.g., self-esteem, attitudes toward SB) and physiological elements (e.g., capacities, health)], interpersonal [Social support of caregivers (parental rules, peers&#x00027; behavior, encouragement from teachers&#x02026;)], and organizational [Home; institution (care center, school): physical and social aspects (e.g., school wellness policy, garden equipment)] characteristics, and finally societal level including community Neighborhood, community environment (e.g., local associations) and public policies (Laws, national and local regulations (e.g., transport system, media, sports facilities in the city) (<xref ref-type="bibr" rid="B17">17</xref>).</p>
<p>The growing literature claiming for multilevel interventions assumed a larger effect on health outcomes, in comparison to single-level (intrapersonal) strategies but this argument suffers from limited empirical evidence (<xref ref-type="bibr" rid="B18">18</xref>&#x02013;<xref ref-type="bibr" rid="B20">20</xref>).</p>
</sec>
<sec>
<title>Interventions targeting sedentary lifestyle in school-aged populations</title>
<p>Preventive actions of SB are more and more needed among children and young adolescents [WHO guidelines, (<xref ref-type="bibr" rid="B5">5</xref>)]. Studies evaluating these actions in children have been increasing these recent years, and several systematic reviews and/or meta-analyses were published this last decade. Overall, these studies highlight the high heterogeneity of trials and the difficulty to establish strong evidence regarding interventions for the promotion of a less sedentary lifestyle. However, promising strategies are mentioned such as behavior change interventions (<xref ref-type="bibr" rid="B21">21</xref>, <xref ref-type="bibr" rid="B22">22</xref>), electronic TV monitoring devices or TV turn-off (<xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B23">23</xref>). Family and high parental involvement is a crucial interventional strategy (<xref ref-type="bibr" rid="B22">22</xref>, <xref ref-type="bibr" rid="B24">24</xref>, <xref ref-type="bibr" rid="B25">25</xref>), and, when focusing on school environment and policy, studies showed that adequate and accessible facilities for PA, and that educational materials, pedagogic practices and standing desks in classroom are significant opportunities in reducing ST (<xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B23">23</xref>, <xref ref-type="bibr" rid="B26">26</xref>, <xref ref-type="bibr" rid="B27">27</xref>).</p>
<p>Multi-component and mixed interventions, incorporating both behavioral and environmental components (<xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B28">28</xref>) were also mentioned as promising.</p>
<p>To this day, no study has systematically examined the effectiveness of multilevel, socio-ecological-based, interventions on ST-SB only, depending on the types and number of levels targeted by the strategies used. A few reviews have investigated socio-ecological or multilevel interventions specifically but none has focused on the reduction of ST/SB: Meht&#x000E4;l&#x000E4; et al. (<xref ref-type="bibr" rid="B29">29</xref>) investigated socio-ecological-based interventions aiming to increase the level of young (2&#x02013;6 years) children&#x00027;s PA; the review of Kellou et al. (<xref ref-type="bibr" rid="B30">30</xref>) aimed to analyze the effectiveness of interventions preventing overweight in youngsters by promoting PA; in a recent review, Bernal et al. (<xref ref-type="bibr" rid="B20">20</xref>) compared the effectiveness of school-based multi-component vs. mono-component interventions carried out to promote children&#x00027;s PA.</p>
<p>Therefore, the aim of the present review is to systematically summarize evidence regarding the effectiveness of socio-ecological model-based multilevel intervention strategies to reduce ST in children and young adolescents. It aims to answer the following research questions: are interventions using multilevel/socio-ecological framework and targeting SB effective to reduce ST in children? Are these interventions more effective when they target more levels? In addition, as previously mentioned, to reduce ST, family-based interventions could be more effective if they use a strong parental involvement as a key strategy and not just as a supervisory role. This has led us to consider, in this review, not only the settings or the levels of the intervention, but also the involvement or not, and the degree of involvement of caregivers or social support surrounding the child (e.g., parents, teachers): are these multilevel interventions more effective when they involve a stakeholder/level representative (e.g., teacher, parent) at a strong degree?</p>
</sec>
</sec>
<sec sec-type="methods" id="s2">
<title>Methods</title>
<p>The present article reports a systematic review that has been conducted according to The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The review aims and methods were registered on PROSPERO (registration nr CRD42020209653).</p>
<sec>
<title>Systematic literature search and inclusion/exclusion criteria</title>
<p>Studies were included when they met the following PICOS criteria:</p>
<list list-type="simple">
<list-item><p>(i) P(Population): studies on healthy human subjects (i.e., no clinical population) that involve school-aged children (i.e., between 5 and 12 years-old) were included; studies with preschool &#x0003C; 5 years old and adolescents aged more than 12 were then excluded; studies involving only high-risk populations, defined as children or young adolescents being overweight with high risk of obesity, obese, or specific clinical populations (e.g., young with pathologies, e.g., cancer, or any disease) were excluded. Studies comparing normal weight children and obese children were included when results for the normal weight children were described separately.</p></list-item>
<list-item><p>(ii) I (Intervention): I (Intervention): intervention had to consider the reduction of ST, even if other health behaviors (e.g., nutrition habits, PA) could be mainly targeted; studies with interventions targeting at least two among the five levels of intervention according to the socio-ecological model of McLeroy et al. (<xref ref-type="bibr" rid="B15">15</xref>) (i.e., intra-, interpersonal, organizational, community-, society-based) were included;</p></list-item>
<list-item><p>(iii) C (Control), only studies with a control, or a comparison group (e.g., alternative intervention) were considered;</p></list-item>
<list-item><p>(iv) O (Outcome): studies had to report measures related to SB (e.g., TV viewing, computer-use, sitting-time); either objective (e.g., accelerometry) or reported (e.g., questionnaire) measures were considered.</p></list-item>
<list-item><p>(v) S (Study design): to be included, the study design had to test an intervention and to involve a comparative group. Randomized (or cluster randomized) studies were included but randomization was not mandatory. Studies performed in laboratory settings, studies without a control or comparative group, and cohort studies were excluded.</p></list-item>
</list>
</sec>
<sec>
<title>Searching process</title>
<p>An electronic database search of PubMed (MEDLINE), PsycInfo and ERIC has been performed through the end of July 2021 (data published from 2000 to the present days, July 2021) languages restricted to English and French. We decided to start selection in 2000 as there has been growing consideration regarding ST and SB, and more particularly for a wide range of &#x0201C;screen-time related behaviors&#x0201D; (<xref ref-type="bibr" rid="B2">2</xref>) in these last two decades. Studies targeting only TV-viewing or computer-use seem to not accurately reflect a growing reality for children and young adolescents. Indeed, in young populations, most of the ST is made up of modern screen items that arose in the 2,000 decade (e.g., computer/laptop, smartphone, tablet (<xref ref-type="bibr" rid="B31">31</xref>). We used a combination of keywords related to sedentary lifestyle and screen-related behavior, public health interventions, preventive actions, and socio-ecological model, multilevel strategies or studies targeting several environments.</p>
<p>Finally, the research algorithm was the following: (sedentar<sup>&#x0002A;</sup> OR screen<sup>&#x0002A;</sup> OR multimedia) AND (intervention<sup>&#x0002A;</sup> OR promot<sup>&#x0002A;</sup> OR prevent<sup>&#x0002A;</sup>) AND (multi<sup>&#x0002A;</sup> OR ecologic<sup>&#x0002A;</sup> OR environment<sup>&#x0002A;</sup> OR context<sup>&#x0002A;</sup>) NOT (disease<sup>&#x0002A;</sup> OR patholog<sup>&#x0002A;</sup>). Limiters were the following: age ranging from 5 to 12 years; the study design: comparative, controlled, multicenter studies were included; the languages English and French; and the period of publication, starting from 2000 to July 2021.</p>
<p>First, the first author MCG selected eligible studies based on the title and/or the abstract and assessed the inclusion criteria to determine preliminary eligibility of studies. Following the PRISMA guidelines, at this first step of the selection on abstract, the author applied the PICOS method to check if the data fit the following inclusion criteria.</p>
<p>Second, MCG and MC separately read the full text, using the inclusion PICOS criteria to assess the final inclusion of articles. Any discrepancies were discussed until consensus was reached. MCG and SL extracted relevant data including methodology, participants, outcomes, and results. The following data were extracted: concerning the methodology, population details (country of intervention, number of and age mean or range of participants in control and intervention group), duration of intervention, use and type of theoretical framework, main setting (e.g., school, home) of intervention, study timelines. Each level targeted were identify; for the intrapersonal level, type of strategies (i.e., informational vs. behavioral) was detailed; in the interpersonal level, the type and degree of involvement (&#x0201C;&#x0002B;&#x0201D; if strong, meaning being active, &#x0201C;-&#x0201D; if rated weak, meaning passive) of caregivers (e.g., teachers, parents) were indicated. At the organizational level, type of setting was mentioned (e.g., school, home) with, for each of them, an indication of the kind of environment components (i.e., Physical, P, Social, S) targeted. Finally, results on SB-ST were briefly reported.</p>
<p>These elements are documented below in the summary <bold>Table 2</bold>, and described in results.</p>
<p>SL, PD, and MC checked the salient data and the methodological quality of trials included. Any discrepancies were resolved by discussion.</p>
</sec>
<sec>
<title>Methodological quality</title>
<p>The methodological quality of each trial was examined using an 11-item scale derived from Cochrane collaboration&#x00027;s tools for assessing risk of bias in RCTs (<xref ref-type="bibr" rid="B81">81</xref>). This adapted scale, used by Gourlan et al. (<xref ref-type="bibr" rid="B82">82</xref>) in their review, assesses information of studies regarding (1) the eligibility criteria for participants; (2) the details of the intervention provided for each intervention level; (3) if the process of the intervention implementation was monitored; (4) the specific objective(s) of the study clearly mentioned; (5) the calculation technique used to determine the sample size was mentioned; (6) the method used to randomize participants [if randomization was used]; (7) the blinding to group assignment of assessors; (8) the participants flow; (9) the characteristics of the care providers performing the intervention; (10) the baseline data of participants are described for intervention and control groups; and (11) the number of participants included in each analysis is mentioned. All items were coded as &#x0201C;yes&#x0201D; (&#x0002B;), &#x0201C;no&#x0201D; (-) or &#x0201C;not applicable&#x0201D; (NA).</p>
</sec>
</sec>
<sec sec-type="results" id="s3">
<title>Results</title>
<sec>
<title>Studies selection process</title>
<p>The literature search yielded a total of 6,166 publications: 1,821 in Pubmed, 1,590 in ERIC and 2,755 in PsychInfo. The searching and selection process is summarized in the flow chart presented below, <xref ref-type="fig" rid="F1">Figure 1</xref>. After removing duplicates (<italic>n</italic> = 5,842) and checking eligibility of the studies, a total of 30 relevant studies were finally included in this systematic review (reported by 51 publications, including e.g., protocol, midway, follow-up publications).</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p>PRISMA flow diagram of the review (<xref ref-type="bibr" rid="B83">83</xref>).</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpubh-11-1106206-g0001.tif"/>
</fig>
</sec>
<sec>
<title>Methodological quality</title>
<p>Briefly, based on the quality assessment form, most of the trials (<italic>n</italic> = 18 out of 30) demonstrated acceptable quality (i.e., rated under 8, on a total of 11 points), and 12 high quality (i.e., scoring &#x02265; 8). Concerning the criterion, the calculation technique used to determine the sample size of the trial was mentioned in less than half of the studies (<italic>n</italic> = 12 out of 30), and blinding to group assignment of assessors was mentioned in two trials only. Four studies were not randomized and among the others, 15 trials did not mention the method used to randomize participants. All studies clearly provided specific objectives, and most of them provided details of the intervention for each level (<italic>n</italic> = 28), participants&#x00027; eligibility criteria (<italic>n</italic> = 21) and baseline characteristics (<italic>n</italic> = 29).</p>
<p>The following <xref ref-type="table" rid="T1">Table 1</xref> summarizes the methodological quality assessment and reports the rate for each criterion and for each study selected.</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p>Methodological quality assessment of interventions selected for the review (detail by criterion and global quality score).</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:&#x00023;919498;color:&#x00023;ffffff">
<th/>
<th valign="top" align="center"><bold>Eligibility criteria for participants</bold></th>
<th valign="top" align="center"><bold>Details of the intervention provided for each level</bold></th>
<th valign="top" align="center"><bold>Process of the intervention implementation was monitored</bold></th>
<th valign="top" align="center"><bold>Specific objective(s) mentioned</bold></th>
<th valign="top" align="center"><bold>Calculation technique used to determine the sample size mentioned</bold></th>
<th valign="top" align="center"><bold>Method used to randomize participants</bold></th>
<th valign="top" align="center"><bold>Blinding to group assignment of assessors</bold></th>
<th valign="top" align="center"><bold>Participantsflow chart</bold></th>
<th valign="top" align="center"><bold>Characteristics of the care providers performing the intervention</bold></th>
<th valign="top" align="center"><bold>Baseline data of participants (Int/cont groups)</bold></th>
<th valign="top" align="center"><bold>Number of participants included in each analysis</bold></th>
<th valign="top" align="center"><bold>Qualityassessment score</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Breslin et al. (<xref ref-type="bibr" rid="B32">32</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">NA</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">6</td>
</tr> <tr>
<td valign="top" align="left">Carson et al. (<xref ref-type="bibr" rid="B33">33</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">9</td>
</tr> <tr>
<td valign="top" align="left">Duncan et al. (<xref ref-type="bibr" rid="B35">35</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">5</td>
</tr> <tr>
<td valign="top" align="left">Elder et al. (<xref ref-type="bibr" rid="B36">36</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">6</td>
</tr> <tr>
<td valign="top" align="left">Elder et al. (<xref ref-type="bibr" rid="B37">37</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">8</td>
</tr> <tr>
<td valign="top" align="left">Engelen et al. (<xref ref-type="bibr" rid="B38">38</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">8</td>
</tr> <tr>
<td valign="top" align="left">Escobar-Chaves et al. (<xref ref-type="bibr" rid="B40">40</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">3</td>
</tr> <tr>
<td valign="top" align="left">Folta et al. (<xref ref-type="bibr" rid="B41">41</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">NA</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">French et al. (<xref ref-type="bibr" rid="B43">43</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">6</td>
</tr> <tr>
<td valign="top" align="left">Gentile et al. (<xref ref-type="bibr" rid="B45">45</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">Harrison et al. (<xref ref-type="bibr" rid="B47">47</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">6</td>
</tr> <tr>
<td valign="top" align="left">Kattelmann et al. (<xref ref-type="bibr" rid="B48">48</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">Kipping et al. (<xref ref-type="bibr" rid="B84">84</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">8</td>
</tr> <tr>
<td valign="top" align="left">Kipping et al. (<xref ref-type="bibr" rid="B50">50</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">11</td>
</tr> <tr>
<td valign="top" align="left">Kobel et al. (<xref ref-type="bibr" rid="B55">55</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">9</td>
</tr> <tr>
<td valign="top" align="left">Lynch et al. (<xref ref-type="bibr" rid="B56">56</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">Madsen et al. (<xref ref-type="bibr" rid="B57">57</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">8</td>
</tr> <tr>
<td valign="top" align="left">Ni-Mhurchu et al. (<xref ref-type="bibr" rid="B59">59</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">10</td>
</tr> <tr>
<td valign="top" align="left">Nyberg et al. (<xref ref-type="bibr" rid="B60">60</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">8</td>
</tr> <tr>
<td valign="top" align="left">Pablos et al. (<xref ref-type="bibr" rid="B62">62</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">Pearson et al. (<xref ref-type="bibr" rid="B63">63</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">8</td>
</tr>
<tr>
<td valign="top" align="left">Salmon et al. (<xref ref-type="bibr" rid="B64">64</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">9</td>
</tr> <tr>
<td valign="top" align="left">Simon et al. (<xref ref-type="bibr" rid="B66">66</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">8</td>
</tr> <tr>
<td valign="top" align="left">Taylor et al. (<xref ref-type="bibr" rid="B70">70</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">Todd et al. (<xref ref-type="bibr" rid="B71">71</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">6</td>
</tr> <tr>
<td valign="top" align="left">Van Kann et al. (<xref ref-type="bibr" rid="B72">72</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">NA</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">4</td>
</tr> <tr>
<td valign="top" align="left">Van Stralen et al. (<xref ref-type="bibr" rid="B73">73</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">NA</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">4</td>
</tr> <tr>
<td valign="top" align="left">Verloigne et al. (<xref ref-type="bibr" rid="B75">75</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">6</td>
</tr> <tr>
<td valign="top" align="left">Vik et al. (<xref ref-type="bibr" rid="B79">79</xref>)</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">7</td>
</tr> <tr>
<td valign="top" align="left">Wright et al. (<xref ref-type="bibr" rid="B80">80</xref>)</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">-</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">&#x0002B;</td>
<td valign="top" align="center">7</td>
</tr></tbody>
</table>
</table-wrap>
</sec>
<sec>
<title>Characteristics of trials included</title>
<p>The salient data are summarized in <xref ref-type="table" rid="T2">Table 2</xref> with a description of the participants&#x00027; characteristics and main details of the intervention (duration, settings, theoretical framework, assessment methods, main results on ST-SB, strategies by level targeted, degree of caregiver&#x00027;s involvement).</p>
<table-wrap position="float" id="T2">
<label>Table 2</label>
<caption><p>Main characteristics of trials and strategies by levels targeted.</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:&#x00023;919498;color:&#x00023;ffffff">
<th valign="top" align="left"><bold>References study name, design [additional study]</bold></th>
<th valign="top" align="left"><bold>Population details; Country</bold></th>
<th valign="top" align="center"><bold>Duration</bold></th>
<th valign="top" align="left"><bold>Theoretical framework</bold></th>
<th valign="top" align="left"><bold>Main settings</bold></th>
<th valign="top" align="left"><bold>Study timelines</bold></th>
<th valign="top" align="left"><bold>Assessment of SB-ST</bold></th>
<th valign="top" align="left"><bold>Results on SB-ST</bold></th>
<th valign="top" align="left"><bold>Intrapersonal level (Informational, behavioral components)</bold></th>
<th valign="top" align="left"><bold>Interpersonal level (social support) and Caregivers&#x00027; involvement (strong &#x0002B;/weak -)</bold></th>
<th valign="top" align="left"><bold>Organizational level (physical (P) and social (S) components)</bold></th>
<th valign="top" align="left"><bold>Community level</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Breslin et al. (<xref ref-type="bibr" rid="B32">32</xref>) Sport for LIFE CT</td>
<td valign="top" align="left"><italic>N =</italic> 416 IG, n =209; Mage = 9.12 (0.37) CG, <italic>N =</italic> 207; Mage = 9.09 (0.35) low SES; Ireland</td>
<td valign="top" align="center">12 w</td>
<td valign="top" align="left">Social cognitive theory</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">ST: accelerometers<break/> Screen behavior:<break/> Children survey</td>
<td valign="top" align="left">IG: &#x02193; SB (15 h-18 h and 18 h-bedtime)</td>
<td valign="top" align="left">Knowledge and behavior (class sessions and computer tailoring program; personal tailored feedback with specific suggestions to reduce screen-behavior)</td>
<td valign="top" align="left">Teachers (&#x0002B;) lead the implementation; principals and health nurses involved; Parents (&#x0002B;) (fact sheets informing and encouraging involvement in SB regulation &#x0002B; committees)</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Carson et al. (<xref ref-type="bibr" rid="B33">33</xref>) Transform-Us! RCT [Salmon et al. (<xref ref-type="bibr" rid="B34">34</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 293, 7 to 9y [SB] <italic>N =</italic> 74; [PA] <italic>n =</italic> 75; [SB&#x0002B;PA] <italic>N =</italic> 80; GC = 64; Australia</td>
<td valign="top" align="center">24m</td>
<td valign="top" align="left">Social cognitive and behavioral theory; ecological systems model</td>
<td valign="top" align="left">School and family</td>
<td valign="top" align="left">Baseline and midway (5&#x02013;9 months)</td>
<td valign="top" align="left">ST: accelerometers</td>
<td valign="top" align="left">[SB &#x0002B; PA] group: &#x02193; ST in weekday</td>
<td valign="top" align="left">Knowledge and behavior key learning messages (class lessons) (e.g., social support, feedback); standing class lesson per day (30mn) and 2-min light active break</td>
<td valign="top" align="left">PE teachers (&#x0002B;): delivered content and active break, promoted PA at recess, made equipment available parents (-): newsletters supporting the key learning messages delivered</td>
<td valign="top" align="left">School and home (S and P environment: standing opportunities in classroom, PA equipment and asphalt line in playground)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Duncan et al. (<xref ref-type="bibr" rid="B35">35</xref>) Healthy Homework RCT pilot study</td>
<td valign="top" align="left"><italic>N =</italic> 97; (57 IG, 40 CG) 9-11y; low SES; New Zealand</td>
<td valign="top" align="center">6w</td>
<td valign="top" align="left">Social cognitive/Behavior change theories</td>
<td valign="top" align="left">School and home</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Self-reported screen time:<break/> Children daily diary</td>
<td valign="top" align="left">No effect on SB</td>
<td valign="top" align="left">knowledge and behavior: homework booklet (5 PA and 5 nutrition topics) with reward, and in-class teaching resource; group presentations; Healthy Homework website</td>
<td valign="top" align="left">Teachers (&#x0002B;): active assistance, Parents (&#x0002B;) homework, tasks designed to encourage parental participation and knowledge formation</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Elder et al. (<xref ref-type="bibr" rid="B36">36</xref>) Aventuras para Ni&#x000F1;os RCT</td>
<td valign="top" align="left">13 schools, 5-7y children low-income neighborhood; USA</td>
<td valign="top" align="center">1y</td>
<td valign="top" align="left">Social ecological model</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Direct observation:<break/> Researchers collected SOPLAY data</td>
<td valign="top" align="left">Supervised area; Area with equipment: &#x02191; number of boys engaged in SB (IG) Area organized activity: &#x02191; number of boys engaged in SB (CG</td>
<td valign="top" align="left">Behavior Trained ambassadors; &#x0201C;walking clubs&#x0201D;, &#x0201C;Super Aventuras&#x0201D; (activities options); incentives for participation (e.g., stickers, jump ropes, balls), training sessions</td>
<td valign="top" align="left">Parents (&#x0002B;): help for playground game marking Teachers (-): received feedback by the &#x0201C;promotoras&#x0201D; who led the implementation</td>
<td valign="top" align="left">School (S and P): line marking playground</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Elder et al. (<xref ref-type="bibr" rid="B37">37</xref>) MOVE/me Muevo RCT</td>
<td valign="top" align="left">541 families with children 5-8 y Public recreation centers in IG (<italic>n =</italic> 15), and control (<italic>n =</italic> 15); USA</td>
<td valign="top" align="center">2y</td>
<td valign="top" align="left">x</td>
<td valign="top" align="left">City recreation centers and Home</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">ST: accelerometers</td>
<td valign="top" align="left">Non-significant differences on ST</td>
<td/>
<td valign="top" align="left">Parents (&#x0002B;): household rules. 10-min telephone survey; 1<inline-formula><mml:math id="M1"><mml:mfrac><mml:mrow><mml:mn>1</mml:mn></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:mfrac></mml:math></inline-formula> hour group workshop with tip sheets (and by mail) at the recreation center, and a one-hour home visit. FU 10mn phone calls Recreation center directors (&#x0002B;): attendance of community members and enrollment of children in PA programs. Monthly meeting of recreational with intervention personal: action plan, monitor progress, and implement sustainable health policies</td>
<td valign="top" align="left">Home and recreation center (P and S aspects, e.g., healthy food and beverage offerings within the centers)</td>
<td valign="top" align="left">Health policies (recreational center) &#x0201C;community members&#x0201D;</td>
</tr>
<tr>
<td valign="top" align="left">Engelen et al. (<xref ref-type="bibr" rid="B38">38</xref>) It&#x00027;s child play RCT [Bundy et al. (<xref ref-type="bibr" rid="B39">39</xref>)]</td>
<td valign="top" align="left">226 children (5&#x02013;7 y); Australia</td>
<td valign="top" align="center">13w</td>
<td valign="top" align="left">Intrinsic motivation</td>
<td valign="top" align="left">School (playground)</td>
<td valign="top" align="left">Baseline, post and post&#x0002B;2years</td>
<td valign="top" align="left">ST: accelerometers</td>
<td valign="top" align="left">IG: &#x02193; in sedentary activity during break times during breaktime: &#x02193;SB (IG p=0,01) after 2 years: maintain of the gains</td>
<td/>
<td valign="top" align="left">Teachers (-) and Parents (-): task and discussion: examine their own experiences and beliefs regarding the benefits and risks associated with active free play</td>
<td valign="top" align="left">School (S and P: loose materials for playground)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Escobar-Chaves et al. (<xref ref-type="bibr" rid="B40">40</xref>) Fun Families RCT</td>
<td valign="top" align="left">202 families (101 int/GC) children 8.2 &#x000B1; 0.8 y; USA</td>
<td valign="top" align="center">6m</td>
<td valign="top" align="left">Socio-cognitive theory; mapping intervention process</td>
<td valign="top" align="left">Home</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Parent&#x00027;s survey:<break/> media environment, media used by child and family screen habits</td>
<td valign="top" align="left">IG: less likely to report the TV being on when nobody was watching and to have a TV in the child&#x00027;s bedroom trend toward reducing actual media consumption but did not reach statistical significance</td>
<td valign="top" align="left">Knowledge and behavior discussions about puppet show (TV and media), creation of his hand puppet, brainstorming about alternative activities, make a healthy snack</td>
<td valign="top" align="left">Parents (&#x0002B;): 2-hour workshop (puppet show, interactive, and discussions) and 6 bimonthly newsletters. Behavioral objectives (e.g., no TV in the child&#x00027;s bedroom); Common work families and children: &#x0226A; Fun family plan &#x0226B; alternative activities</td>
<td valign="top" align="left">Home (S and P: no TV in bedroom)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Folta et al. (<xref ref-type="bibr" rid="B41">41</xref>) CT Shape Up Sommerville; [Economos et al. (<xref ref-type="bibr" rid="B42">42</xref>)]</td>
<td valign="top" align="left">GI = 647; GC = 1074 6-8 y culturally diverse urban communities; USA</td>
<td valign="top" align="center">2y</td>
<td valign="top" align="left">Social Ecological Model</td>
<td valign="top" align="left">School, home and community</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Family survey form filled by parents/caregivers</td>
<td valign="top" align="left">IG &#x02193; screen time &#x02193; Overall screen time (-0,24h/day)</td>
<td valign="top" align="left">Knowledge and behavior taste tests with adult coordinators, who supervised the meal and modeled healthy eating. Walk to School Campaign</td>
<td valign="top" align="left">Parents (-): home environment was targeted through parent nutrition forums and newsletters</td>
<td valign="top" align="left">School (S and P: beverages provided for snack in the classroom, sold as a la carte snacks to meet nutritional guidelines)</td>
<td valign="top" align="left">Community environment: restaurants: alternative to sugar-sweetened beverage partnered with community members (&#x0002B;) (id, design and implement/evaluation)</td>
</tr>
<tr>
<td valign="top" align="left">French et al. (<xref ref-type="bibr" rid="B43">43</xref>) RCT, pilot study; NET-Works; [French et al. (<xref ref-type="bibr" rid="B44">44</xref>)]</td>
<td valign="top" align="left">IG: <italic>N =</italic> 25 GC: <italic>n =</italic> 15 (5-12 y); lower-income, minority and overweight children; USA</td>
<td valign="top" align="center">6m</td>
<td valign="top" align="left">Socio-ecological and behavior change</td>
<td valign="top" align="left">Home</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">ST:<break/> accelerometers<break/> Parents survey reported child screen habit</td>
<td valign="top" align="left">IG: TV viewing alone (h/day) was lower than CG after 24 months (-16%) and 36 months (-12%); TV and computer use was lower than CG after 24 months</td>
<td valign="top" align="left">Behavior Work with parents and children to limit screen time on all devices</td>
<td valign="top" align="left">Parents (&#x0002B;): home visit and 5 monthly telephone calls, TV locking device with discussion and agreement; other small screens: work to limit child use and implement family home rules</td>
<td valign="top" align="left">Home (S and P: locking device on TV, non-caloric beverages given)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Gentile et al. (<xref ref-type="bibr" rid="B45">45</xref>) RCT Switch program; [Eisenmann et al. (<xref ref-type="bibr" rid="B46">46</xref>)]</td>
<td valign="top" align="left">GC <italic>n =</italic> 674 GI: <italic>n =</italic> 685 Mage = 9.6 (0.9); USA</td>
<td valign="top" align="center">9m</td>
<td valign="top" align="left">Brofenbrenner&#x00027;s Ecological Model</td>
<td valign="top" align="left">School and community</td>
<td valign="top" align="left">Baseline, post and 6months FU</td>
<td valign="top" align="left">Screen time reported by both parents and children</td>
<td valign="top" align="left">Post-intervention: &#x02193;parents reported screen time (persistency after 6 month)</td>
<td valign="top" align="left">Knowledge and behavior Identify healthy behavior, attitudes toward changeset (Do, view, Chew); achievement, short- and long-term goals; monthly: materials and resources to facilitate healthy target behaviors; behavioral tools to assist parents and children</td>
<td valign="top" align="left">Parents (&#x0002B;): identify health behaviors, resources and materials for behavioral change Teachers (&#x0002B;): materials and ways to integrate key concepts into their existing curricula not required to participate</td>
<td valign="top" align="left">Home, community and school (S)</td>
<td valign="top" align="left">public education intervention leadership group: leaders and project grantors from education, health care, government, business and the faith communities</td>
</tr> <tr>
<td valign="top" align="left">Harrison et al. (<xref ref-type="bibr" rid="B47">47</xref>) &#x0201C;Switch Off&#x02014;Get Active&#x0201D; RCT</td>
<td valign="top" align="left"><italic>N =</italic> 312 10.2 &#x000B1; 0.7 y school social disadvantage area; Ireland</td>
<td valign="top" align="center">16w</td>
<td valign="top" align="left">Social cognitive theory for behavior change</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Self-reported &#x0201C;1-day previous day physical activity recall&#x0201D; survey (PDPAR)</td>
<td valign="top" align="left">IG: no difference in self-reported ST individual school analysis: &#x02193; Screen time: for 4/5 IG and 2/4 CG</td>
<td/>
<td valign="top" align="left">Teachers (&#x0002B;) (10-lesson, teacher-led intervention) Parents (&#x0002B;) encouraged in writing to support children in their attempts &#x00026;check behavior</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Kattelmann et al. (<xref ref-type="bibr" rid="B48">48</xref>) iCook 4-H RCT; [Franzen-Castle et al. (<xref ref-type="bibr" rid="B49">49</xref>)]</td>
<td valign="top" align="left">228 youth (9-10y) &#x02013;adult pairs; low-income and/or rural populations USA</td>
<td valign="top" align="center">12w</td>
<td valign="top" align="left">Social Cognitive Theory 4-H model of empowering youth</td>
<td valign="top" align="left">Home</td>
<td valign="top" align="left">Baseline and 4, 12, and 24 months</td>
<td valign="top" align="left">ST:<break/> accelerometers</td>
<td valign="top" align="left">IG: ST increased</td>
<td valign="top" align="left">Knowledge and behavior I-Cook 4H: curriculum about cooking, eating, and playing together for healthful lifestyles; website to share and interact</td>
<td valign="top" align="left">Parents (&#x0002B;): family activities; monthly newsletter that included the monthly challenge winners; Booster events: interact with other families (group playing games)</td>
<td valign="top" align="left">Home (S)</td>
<td valign="top" align="left">Community-based participatory research: Steering committees (research team, extension/4-H staff, Expanded Food and Nutrition Education Program staff (EFNEP), community members, and graduate students)</td>
</tr> <tr>
<td valign="top" align="left">Kipping et al. (<xref ref-type="bibr" rid="B50">50</xref>) Active for life RCT, pilot study</td>
<td valign="top" align="left"><italic>N =</italic> 679 (9&#x02013;10y); UK</td>
<td valign="top" align="center">5m</td>
<td valign="top" align="left">Social Cognitive Theory</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Screen based activities self-reported by questionnaire</td>
<td valign="top" align="left">IG: less time on screen-viewing than CG (non-significant). These differences were imprecisely estimated</td>
<td valign="top" align="left">Knowledge and behavior<break/> Lessons on healthy eating, PA and reducing TV viewing; games and activities</td>
<td valign="top" align="left">Teachers (&#x0002B;): led lessons</td>
<td valign="top" align="left">School (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Kipping et al. (<xref ref-type="bibr" rid="B50">50</xref>) AFLY5 - AFLY5 RCT [Lawlor et al. (<xref ref-type="bibr" rid="B51">51</xref>, <xref ref-type="bibr" rid="B52">52</xref>); Dreyhaupt et al. (<xref ref-type="bibr" rid="B53">53</xref>); Anderson et al. (<xref ref-type="bibr" rid="B54">54</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 2221; 8-9 y; IG <italic>N =</italic> 1064; CG <italic>N =</italic> 1157; UK</td>
<td valign="top" align="center">1y</td>
<td valign="top" align="left">Social Cognitive Theory</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline, post and 1-year FU</td>
<td valign="top" align="left">ST: accelerometers Screen viewing: self-reported by questionnaire</td>
<td valign="top" align="left">No effect on objective ST; After taking account of multiple testing in analyses: effect on self-reported time spent on screen viewing at the weekend (Saturday) in IG</td>
<td valign="top" align="left">Knowledge and behavior lessons on school-time (contents promoting PA, healthy nutrition, and strategies to achieve healthy behaviors) and games (same topics), family activities at home</td>
<td valign="top" align="left">Parents (&#x0002B;): newsletter and homework parent-child interactive homework activities (e.g., &#x0201C;freeze my TV&#x0201D;, alternative active activities) Teachers (&#x0002B;): 16 lesson plans and teaching materials</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Kobel (<xref ref-type="bibr" rid="B55">55</xref>) &#x0201C;Join the Healthy Boat&#x0201D; RCT</td>
<td valign="top" align="left"><italic>N =</italic> 1736; IG: <italic>N =</italic> 954; CG: <italic>N =</italic> 782 (7.1 &#x000B1; 0.6 years); Germany</td>
<td valign="top" align="center">1y</td>
<td valign="top" align="left">Social Cognitive Theory</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Screen media use (SMU): parental questionnaire</td>
<td valign="top" align="left">SMU: IG: for girls, children without a migration background and children whose parents have low education level: &#x02193; screen media use by day.</td>
<td valign="top" align="left">Knowledge and behavior<break/> lessons (curriculum) and teaching materials offering action alternatives for recreational activities without screen media, PA, and a healthy diet<break/> &#x0002B; website to interact</td>
<td valign="top" align="left">Teachers (&#x0002B;): led lessons</td>
<td valign="top" align="left">School (S)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Lynch et al. (<xref ref-type="bibr" rid="B56">56</xref>) Let&#x00027;s Go! 5-2-1-0 RCT, pilot study</td>
<td valign="top" align="left"><italic>N =</italic> 51, IG = 29, CG = 22 Mage = 8; USA</td>
<td valign="top" align="center">4m</td>
<td valign="top" align="left">x</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Reported ST: &#x0201C;Healthy Habits Survey&#x0201D; completed<break/> by caregiver</td>
<td valign="top" align="left">No statistical difference for ST</td>
<td valign="top" align="left">Knowledge<break/> key daily messages; Topics: weight, fruits and vegetables, recreational screen-time, PA, nutrition, sugary drink</td>
<td valign="top" align="left">Parents (-) and teachers (-): packet of information, prepared by the study team and sent home by teachers curriculum administered by nursing student, public health nurse, or a patient education specialist</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Madsen et al. (<xref ref-type="bibr" rid="B57">57</xref>) Energy Balance 4 Kids EB4K with Play RCT [Myers et al. (<xref ref-type="bibr" rid="B58">58</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 879 GI = 583 GC = 296 4th and 5th grade low-income,; USA</td>
<td valign="top" align="center">2y</td>
<td valign="top" align="left">x</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline, midpoint, and endpoint</td>
<td valign="top" align="left">ST: accelerometers</td>
<td valign="top" align="left">no difference for ST; <italic>post-hoc</italic> analyses stratified by grade: 4th-grade IG: &#x02193; school-day ST</td>
<td valign="top" align="left">Knowledge and behavior<break/> 12-week nutrition and energy balance education/PA curriculum<break/> Playworks coach structured recess activities before and during school hours to encourage active participation and led a PA session with individual classes every other week</td>
<td valign="top" align="left">Parents (&#x0002B;) and teachers (&#x0002B;): trained to implement Playworks games and classroom management strategies in PE sessions team of school staff and parents to implement classroom wellness policies and make improvements in school food</td>
<td valign="top" align="left">S and P school environment: classroom wellness policies/school food packaging equipment for the district&#x00027;s central kitchen</td>
<td valign="top" align="left">Partnerships with national organization Play works; afterschool sports leagues</td>
</tr> <tr>
<td valign="top" align="left">Ni-Mhurchu et al. (<xref ref-type="bibr" rid="B59">59</xref>) RCT, pilot study</td>
<td valign="top" align="left"><italic>N =</italic> 29 IG <italic>N =</italic> 15; 10.4 &#x000B1; 0.9 y; CG <italic>N =</italic> 14; 10.4 &#x000B1; 0.9 y; New-Zealand</td>
<td valign="top" align="center">6w</td>
<td valign="top" align="left">x</td>
<td valign="top" align="left">Home</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Frequency and duration of TV watching self-report by questionnaire</td>
<td valign="top" align="left">Time spent watching TV &#x02193; by 4.2 h/week in the IG but difference not statistically significant. Both groups reported decreases in total ST, between-group differences were not statistically significant</td>
<td/>
<td valign="top" align="left">Parents (&#x0002B;) discussion: use of the Time Machine in the household, ideas to manage TV watching (e.g., rules as no TV during meal times, moving the TV)</td>
<td valign="top" align="left">Home S and P (time monitor)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Nyberg et al. (<xref ref-type="bibr" rid="B60">60</xref>) Healthy School Start RCT; [Nyberg et al. (<xref ref-type="bibr" rid="B61">61</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 243, 6y and parents low to medium SES; Sweden</td>
<td valign="top" align="center">6m</td>
<td valign="top" align="left">Social cognitive theory</td>
<td valign="top" align="left">School and home</td>
<td valign="top" align="left">Baseline, post-intervention and at 6-months FU</td>
<td valign="top" align="left">ST: accelerometry<break/> SB: parent reported (EPAQ questionnaire)</td>
<td valign="top" align="left">Subgroup analyses showed a significant gender-group interaction: &#x02191;ST in boys from IG</td>
<td valign="top" align="left">Knowledge and behavior<break/> classroom activities: children&#x00027;s knowledge, attitudes and preferences and parents&#x00027; role modeling for healthy behaviors<break/> Homework activities with parents</td>
<td valign="top" align="left">Parents (&#x0002B;): brochure sent home: Health information facts and advice (e.g., PA, screen-time) Motivational Interviewing: provide support &#x0002B; choose goal (target child&#x00027;s diet or PA), agenda tool Teachers (&#x0002B;) led classroom activities (with teacher&#x00027;s manual), involved in material/tools development</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Pablos et al. (<xref ref-type="bibr" rid="B62">62</xref>) Healthy Habits Program (HHP) RCT</td>
<td valign="top" align="left"><italic>N =</italic> 158; CG; <italic>N =</italic> 76; IG; <italic>N =</italic> 82 10-12y; Spain</td>
<td valign="top" align="center">8m</td>
<td valign="top" align="left">x</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">SB self-reported by questionnaire (Inventory of Healthy Habits)</td>
<td valign="top" align="left">SB: no significant changes (goal of less than 2 hours of total ST was not achieved)</td>
<td valign="top" align="left">Knowledge and behavior<break/> Healthy habits (diet, PA sleep and hygiene) &#x0002B; physical exercise session with games and worksheets</td>
<td valign="top" align="left">Parents (&#x0002B;) and teachers (&#x0002B;): talks for parents and teachers about healthy habits for school children; worksheet to complete at home, had to be signed each week by the parents</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Pearson et al. (<xref ref-type="bibr" rid="B63">63</xref>) Kids FIRST RCT, pilot study</td>
<td valign="top" align="left">ST and Snacking <italic>N =</italic> 21; ST <italic>N =</italic> 25 Snacking <italic>N =</italic> 14; CG <italic>N =</italic> 15 9-11y UK</td>
<td valign="top" align="center">12w</td>
<td valign="top" align="left">Social ecological and Social Cognitive theories of behavior change.</td>
<td valign="top" align="left">School and home</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">Screen Time self-reported by questionnaire (adaptation of ASAQ)</td>
<td valign="top" align="left">&#x02193;children&#x00027;s school day and weekend day TV/DVD viewing and computer game use in the ST &#x0002B; Sn (snacking) and ST, self-reported smartphone use &#x02191;; study was not powered to detect statistical changes</td>
<td valign="top" align="left">Knowledge and behavior<break/> Key learning messages (knowledge about ST/Sn outcomes) delivered in online child classroom lessons; homework activities/challenges; learning message to be positive role models to family and friends</td>
<td valign="top" align="left">Parents (&#x0002B;): 1 online session and a package of resources (e.g. newsletters) strategies to participate in healthy ST and/or consumption of healthy snacks, Guide on how to implement behavior modification social support: learning message to be positive role mdels</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Salmon et al. (<xref ref-type="bibr" rid="B64">64</xref>) Switch-2-Activity RCT; [Salmon et al. (<xref ref-type="bibr" rid="B65">65</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 1048 9-12 y; Australia</td>
<td valign="top" align="center">20w</td>
<td valign="top" align="left">Social cognitive and behavioral choice theories</td>
<td valign="top" align="left">School and home</td>
<td valign="top" align="left">Baseline, post and 18-months FU</td>
<td valign="top" align="left">Screen-based behaviors self-reported by survey</td>
<td valign="top" align="left">Screen based behavior: sex as moderator IG: &#x02193;ST on week end for boys (-20min) self-efficacy reducing TV viewing: sex interaction IG &#x0003E; CG average change score IG: positive effect on boys and girls</td>
<td valign="top" align="left">Knowledge and behavior<break/> Introduction to AP and health; patterns of TV viewing and self-monitoring; selective TV viewing and behavioral contracting; identifying alternative activities and games; walking (pedometer) and games and activities developed by the children</td>
<td valign="top" align="left">Teachers (&#x0002B;) Delivering material (many teachers reported modifying it in some way)</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Simon et al. (<xref ref-type="bibr" rid="B66">66</xref>) ICAPS RCT; [Simon et al. (<xref ref-type="bibr" rid="B67">67</xref>&#x02013;<xref ref-type="bibr" rid="B69">69</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 954 CG: <italic>n =</italic> 479 IG, <italic>n =</italic> 475 11-12y; France</td>
<td valign="top" align="center">4y</td>
<td valign="top" align="left">Socio-ecological model</td>
<td valign="top" align="left">School, home and community</td>
<td valign="top" align="left">Baseline, post and 2 years FU</td>
<td valign="top" align="left">ST Self-reported (adaptation of the MAQ questionnaire)</td>
<td valign="top" align="left">6months (Simon, 2006): proportion of IG adolescents spending &#x0003E; 3 h/day in sedentary occupations &#x02193; post: IG: &#x02193;of TV viewing time (-16 min/day) FU (2014): differences in ST maintained</td>
<td valign="top" align="left">Knowledge and behavior<break/> objective: changing attitudes through debate and access to attractive activities during breaks and after-school hours, encouraging social support emphasis on fun, meeting with others and absence of competitive aspects</td>
<td valign="top" align="left">Parents, teachers, educators (&#x0002B;) social support: fostered to promote PA and to increase sports participation of children</td>
<td valign="top" align="left">school and home (S and P components) providing environmental conditions (e.g., accessibility) that enable PA</td>
<td valign="top" align="left">Event-specific activities numerous partnerships (medical staffs, PA and club educators, families, territorial and community agencies in charge of recreational areas and transportation infrastructures)</td>
</tr> <tr>
<td valign="top" align="left">Taylor et al. (<xref ref-type="bibr" rid="B70">70</xref>) Active Schools: Skelmersdale (AS:Sk) pilot RCT</td>
<td valign="top" align="left"><italic>N =</italic> 232, 9&#x02013;10 y CG: <italic>n =</italic> 115, IG: <italic>n =</italic> 117 low income; England</td>
<td valign="top" align="center">8w</td>
<td valign="top" align="left">Socio-ecological model, TEO, behavior change models</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">ST: accelerometer</td>
<td valign="top" align="left">IG &#x02193; 9mn school ST</td>
<td valign="top" align="left">Behavior<break/> active breaks, bounce at the bell (suggested jump routine), &#x02018;Born To Move&#x00027; videos, Daily Mile or 100 Mile Club (challenge), playground activity challenge cards</td>
<td valign="top" align="left">Teachers (&#x0002B;) PE teacher training Parents (&#x0002B;): newsletters, homework activity and letters</td>
<td valign="top" align="left">School and home (S and P components: playground installations)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Todd et al. (<xref ref-type="bibr" rid="B71">71</xref>) Pilot RCT</td>
<td valign="top" align="left">IG: <italic>N =</italic> 11 (10.0 &#x000B1; 0.8) CG: <italic>N =</italic> 10 (9.7 &#x000B1; 1.2) boys (excessive screen-use); USA</td>
<td valign="top" align="center">20w</td>
<td valign="top" align="left">x</td>
<td valign="top" align="left">Home</td>
<td valign="top" align="left">Baseline, midpoint (10w), endpoint</td>
<td valign="top" align="left">Electronic media time self-recorded on logbooks</td>
<td valign="top" align="left">10 weeks: IG: &#x02193; of electronic media use (-47%/day) and achieved target (&#x0003C; 90min/day); CG also &#x02193; (-24%) but exceeded the IG and the target (&#x0002B;29 min) At 20 weeks, IG media use remained 8 min/day below the target, CG 5min/day</td>
<td valign="top" align="left">Knowledge and behavior<break/> participants were matched in pairs; seminar designed to enhance awareness of electronic media use and to set goals to minimize use: family-centered interactive session,</td>
<td valign="top" align="left">Parents (&#x0002B;) follow-up daily with the children for completing data; interactive family session (TV), 3 newsletter (TV), follow-up phone call with recommendations</td>
<td valign="top" align="left">School and home (S and P components: monitor device on TV and computer)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Van Kann et al. (<xref ref-type="bibr" rid="B72">72</xref>) Active Living project CT</td>
<td valign="top" align="left"><italic>N =</italic> 791 8&#x02013;11 years; deprived areas Netherlands</td>
<td valign="top" align="center">1y</td>
<td valign="top" align="left">Ecological systems theory</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and 1y effect</td>
<td valign="top" align="left">ST: accelerometer</td>
<td valign="top" align="left">IG:&#x02212;5,9% in SB (nonsignificant) -female gender: significant predictor for more SB (follow up) -children in 7th grade: more time in SB (follow up) intervention components: More and higher intensity PSI= &#x02193;SB (after 12 months)</td>
<td valign="top" align="left">Knowledge presence of posters in school</td>
<td valign="top" align="left">Parents (-) communication in parental newsletters Teachers (&#x0002B;): Schools were supported in implementing physical and social schoolyard interventions to stimulate children&#x00027;s PA, e.g., teachers introducing schoolyard games</td>
<td valign="top" align="left">School S and P (equipment for playground, working budget)</td>
<td valign="top" align="left">Working groups, chaired by a municipal health service employee to identify environmental changes needed</td>
</tr>
<tr>
<td valign="top" align="left">van Stralen et al. (<xref ref-type="bibr" rid="B73">73</xref>) Jump-In CT; [De Meij et al. (<xref ref-type="bibr" rid="B74">74</xref>)]</td>
<td valign="top" align="left"><italic>N =</italic> 600; GI <italic>n =</italic> 259 GC <italic>N =</italic> 341 Mage = 9.8 &#x000B1; 0.7 y; disadvantaged areas; Netherlands</td>
<td valign="top" align="center">2y</td>
<td valign="top" align="left">Precede-proceed model, ecological and socio-cognitive theories</td>
<td valign="top" align="left">School, home</td>
<td valign="top" align="left">Baseline and post (20months)</td>
<td valign="top" align="left">self-reported TV-viewing behavior and computer use</td>
<td valign="top" align="left">Non effective in reducing TV-viewing or computer time</td>
<td valign="top" align="left">Knowledge and behavior<break/> Pupil follow up system, yearly monitoring instruments of PA, BMI and motor skills, personal workbooks for children and their parents with assignments to perform in class and at home and an instruction book for the school staff</td>
<td valign="top" align="left">Teachers/School staff (&#x0002B;) and parents (&#x0002B;) Parental information services including information meetings, courses and sport activities for parents</td>
<td valign="top" align="left">School and home S and P environment (e.g., offer of structural and easily accessible school sport activities)</td>
<td valign="top" align="left">Sports club and local municipalities (short term sports courses, sports competitions and PA game), coordinators and trainers of these local sports activities</td>
</tr> <tr>
<td valign="top" align="left">Verloigne et al. (<xref ref-type="bibr" rid="B75">75</xref>) ENERGY project RCT, pilot intervention; Verloigne et al. (<xref ref-type="bibr" rid="B76">76</xref>, <xref ref-type="bibr" rid="B77">77</xref>), Van Lippevelde, et al. (<xref ref-type="bibr" rid="B78">78</xref>)</td>
<td valign="top" align="left"><italic>N =</italic> 372 Mage = 10.9 &#x000B1; 0.7 y IG= <italic>N =</italic> 141; CG: <italic>N =</italic> 231; Belgium</td>
<td valign="top" align="center">6w</td>
<td valign="top" align="left">Social ecological perspective</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post</td>
<td valign="top" align="left">ST: accelerometers</td>
<td valign="top" align="left">No differences in ST between IG and CG</td>
<td valign="top" align="left">Knowledge and behavior<break/> lessons: awareness and evaluation of sitting time, influencing factors at home, possibilities for activity breaks and active transportation, and Family Fun Event, brainstorming, homework and activities</td>
<td valign="top" align="left">Parents (&#x0002B;): newsletters to involve the parents; personalized messages and homework tasks to be completed at home Family Fun Event Teachers (&#x0002B;): six weeks lasting intervention was conducted by the teachers</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">Vik et al. (<xref ref-type="bibr" rid="B79">79</xref>) UP4Fun RCT</td>
<td valign="top" align="left"><italic>N =</italic> 3147 Mage = 11.2 IG: <italic>N =</italic> 1569 CG <italic>N =</italic> 1578 5 European countries</td>
<td valign="top" align="center">6w</td>
<td valign="top" align="left">Planned Promotion for Population Health and socio-ecological models</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Baseline and post (short-term)</td>
<td valign="top" align="left">Screen time and breaking up sitting time reported by questionnaire, total ST<break/> and breaking up sitting time by accelerometry</td>
<td valign="top" align="left">No significant intervention effects on ST, neither for self-reported or accelerometer-assessed ST</td>
<td valign="top" align="left">Knowledge and behavior<break/> lessons: awareness and evaluation of sitting time, influencing factors at home, possibilities for activity breaks and active transportation, and Family Fun Event, brainstorming, homework and activities</td>
<td valign="top" align="left">Parents (&#x0002B;): newsletters; personalized and homework tasks Family Fun Event Teachers (&#x0002B;): six weeks lasting intervention was conducted by the teachers</td>
<td valign="top" align="left">School and home (S)</td>
<td/>
</tr> <tr>
<td valign="top" align="left">Wright (<xref ref-type="bibr" rid="B80">80</xref>) Kids N Fitness RCT</td>
<td valign="top" align="left"><italic>N =</italic> 251; 8&#x02013;12y urban, low-income neighborhoods; USA</td>
<td valign="top" align="center">4m</td>
<td valign="top" align="left">Community-academic partnered participatory research (CPPR)</td>
<td valign="top" align="left">School, home and community</td>
<td valign="top" align="left">Baseline, 4 months, and 12 months post</td>
<td valign="top" align="left">TV<break/> viewing/computer game playing self-reported by questionnaire</td>
<td valign="top" align="left">TV viewing significantly decreased (to 4 months); effect was sustained at 12 months for males only</td>
<td valign="top" align="left">Knowledge and behavior:<break/> weekly 90-min sessions, PA/SB, nutrition education/behavior modification, and family involvement creative ways to exercise in a non-structured exercise program</td>
<td valign="top" align="left">Educational staff (&#x0002B;): staff professional development in health promotion and parents (&#x0002B;) family involvement sessions, newsletters and involvement as &#x0201C;active community stakeholders&#x0201D;</td>
<td valign="top" align="left">School (S)<break/> (School Wellness Policy involving dietary changes, staff professional development</td>
<td valign="top" align="left">Partnerships with local community clinics; nurse, trained community health workers and PE specialist; active community stakeholders (academicians, school administrators, teachers, parents)</td>
</tr></tbody>
</table>
</table-wrap>
<p>Briefly, the 30 trials were published between 2000 and 2020, in 2006 for the earliest and in 2020 for the most recent with 23 (77%) studies in the last decade. Eleven interventions were conducted in the USA, 15 took place in Europe (e.g., Poland, Sweden, France, Belgium), and 4 in New Zealand, or Australia. Populations from 10 trials were made up of low-income groups from deprived areas; one study (<xref ref-type="bibr" rid="B71">71</xref>) solely targeted boys. Baseline sample sizes ranged from 29 children in a pilot study (<xref ref-type="bibr" rid="B59">59</xref>), to 3,147 in a trial (<xref ref-type="bibr" rid="B79">79</xref>) involving young populations from five European countries. The duration of the delivered interventions ranged from 4 months in the pilot study of Lynch (2016) (<xref ref-type="bibr" rid="B56">56</xref>) to 30 months for the trial led by Wright (2013) (<xref ref-type="bibr" rid="B80">80</xref>).</p>
<p>Social-cognitive theories (of behavior change/motivation) (<xref ref-type="bibr" rid="B85">85</xref>, <xref ref-type="bibr" rid="B86">86</xref>) and socio-ecological models (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B15">15</xref>) are the most frequently theoretical backgrounds mentioned. However, most of the studies (<italic>N</italic> = 18) do not refer to the socio-ecological perspective, or any ecological anchoring, and six studies do not mention any theoretical background.</p>
<p>Among the 30 included studies, the main setting of intervention is school in 24 trials. More precisely, three studies targeted only the home environment, four interventions only the school environment, two studies involved home and community (city recreation center; participatory research) and almost half of the trials (<italic>N</italic> = 14) school and home. For the remaining studies (<italic>N</italic> = 7), interventions were implemented or involved both school, home and community (partnership with community stakeholders, e.g., medical staffs, community health workers, local municipalities, PA club educators, territorial and community agencies in charge of transportation infrastructures).</p>
<p>Reported outcomes included ST or SB for all of the studies, and in 28 (93%) trials, PA outcomes (e.g., steps, sport participation, MVPA) was measured as well; only two trials did not targeted PA: screen-time was assessed in addition to dietary variables, and beverage consumption and BMI (<xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B63">63</xref>). Regarding sedentary assessment, 16 (53%) trials used only subjective assessment of ST-SB: 11 studies reported only self-declared assessment; parental/caregiver questionnaire only, and combined with self-reported measures, were respectively used in 4, and one (<xref ref-type="bibr" rid="B45">45</xref>) study; one trial (<xref ref-type="bibr" rid="B36">36</xref>) used observational data recorded by researchers. Objective assessment was used in 8 trials, that solely used a monitored or device-based method (e.g., pedometer, accelerometer). Finally, a combination of self-declared and device-based, and parent&#x00027;s and device-based assessments were reported in 3, and 2 studies, respectively.</p></sec>
<sec>
<title>Intervention components and strategies by level targeted</title>
<p><xref ref-type="table" rid="T2">Table 2</xref> summarizes the main characteristics of trials, and, for each targeted level, the type of strategy delivered. For the interpersonal level, we also considered the stakeholders/caregivers involved, and the strength of their participation.</p>
<p>Strategies used to deliver interventions can be described according to each socioecological model level.</p>
<p>Regarding the individual level (e.g., intrapersonal characteristics, such as attitudes, intrinsic motivation, skills), strategies were informational (e.g., passive: curriculum school program is designed to include health promotion and recommendation components about SB, energy-balance). Children sometimes received an educational program with key learning messages concerning various health determinants. Indeed, several interventions chose to include a multi-component strategy in delivering healthy messages: lessons and information could concern ST, PA, nutrition, or other health behaviors [e.g., (<xref ref-type="bibr" rid="B35">35</xref>, <xref ref-type="bibr" rid="B48">48</xref>, <xref ref-type="bibr" rid="B50">50</xref>)]. In this case, when the intervention aims to combine the messages on SB and physical activity with other health information, in an attempt to be more effective, it can be not easy to determine which component or part of the strategy was effective in reducing specifically ST, or an outcome isolated. Few studies (<xref ref-type="bibr" rid="B56">56</xref>, <xref ref-type="bibr" rid="B72">72</xref>) mentioned informational determinants or knowledge in the intrapersonal level: e.g., delivering key learning messages (topics about weight, vegetables, recreational screen-time), presence of posters in the school. Cognitive components of strategies delivered could include goal setting to reduce electronic media, brainstorming, action-plan to achieve healthy behaviors or strategies to find alternative games and activities to replace SB. Mainly behavioral components were used in three interventions (<xref ref-type="bibr" rid="B36">36</xref>, <xref ref-type="bibr" rid="B43">43</xref>, <xref ref-type="bibr" rid="B70">70</xref>): e.g., active breaks bounce at the bell, playground activity challenge cards, training sessions, work with parents and children to limit screen-time. Most studies (<italic>N</italic> = 21) used a combination of informational and behavioral strategies (e.g., key learning messages during school lessons and a light active break; behavioral tools to modify behaviors and material and resources to identify healthy behaviors).</p>
<p>At the interpersonal level, one intervention component repeated in several designs of studies was the involvement of caregivers. Social support strategies were operationalized with the participation of parents, or other significant caregivers. The social circle, composed of people closed to the child, could be passively or actively involved: caregivers involved were mainly teachers and/or parents, but in some trials, school staff as principals, educators, health nurses, recreation center directors were also associated in the interpersonal level of intervention. Involvement was rated as &#x0201C;weak&#x0201D; (-) when passive: e.g., teachers who did not lead the lessons, but who were present during the intervention, who sent some information to the child&#x00027;s parents, who just received feedback from the research team who led the implementation. When their involvement was rated as strong (&#x0002B;), teachers could conduct the intervention, participate in material or tools development. Parents who took an active part in the intervention could attend workshops/meetings with their children, had activities or homework tasks to complete with children, or followed educational/motivational sessions with them. These study designs posit that having a supportive family environment can promote the targeted behavior change and be effective in reducing children&#x00027;s ST. Among studies (<italic>N</italic> = 27) targeting parents as social support (i.e., at the interpersonal level), 22 actively or strongly involved them, other studies targeted parents but with a more passive strategy (e.g., informational, as sending newsletters). In most studies (<italic>N</italic> = 20), implication of parents is linked with an involvement of school staff to target the entire social support of children (e.g., teachers, PE educators, nurses, educational staff in health promotion, recreational directors). This involvement is active in 17 trials.</p>
<p>At an environmental level (e.g., organizational, or institutional), almost half of the studies (<italic>N</italic> = 14) reported some physical components targeted: as for example, changes in the home or school physical environment (e.g., removing TV from the child&#x00027;s bedroom, install an electronic TV monitoring device, provide equipment and resources for physical activities, draw an asphalt line in the playground). Many studies were school-based [one was also recreational center based, (<xref ref-type="bibr" rid="B37">37</xref>)], some of them with a combination of school and home components strategies; few studies also included partnership with local municipalities, non-governmental partners, community stakeholders and external professionals (in the shape of collaborators in the field of nutrition, health staff, local community clinics, associations, municipal health employer, local sport clubs). Some actions were thus implemented outside of the initial institutional setting (e.g., steering committees with community members, afterschool sport leagues, sport competitions organized by sports clubs and local municipalities, event-specific activities in the community).</p>
<p>Few studies were community-based with a participatory research design (<xref ref-type="bibr" rid="B41">41</xref>, <xref ref-type="bibr" rid="B45">45</xref>, <xref ref-type="bibr" rid="B48">48</xref>, <xref ref-type="bibr" rid="B80">80</xref>). In their intervention, Folta and others (2014) (<xref ref-type="bibr" rid="B41">41</xref>) targeted home and recreational centers, and the community environment by working with restaurants across the city to provide healthier options (e.g., offering more low-fat dairy products); the authors used a social ecological and systems approach, using community-based participatory research and involving community members in the development and implementation of the intervention. Kattelmann et al. (<xref ref-type="bibr" rid="B48">48</xref>) also used a similar design and formed steering committees composed of members of the research team, Expanded Food and Nutrition Education Program (EFNEP) staff, community members, and graduate students. Simon et al. (<xref ref-type="bibr" rid="B66">66</xref>) proposed, at the community level of their intervention, event-specific activities and established numerous partnerships (i.e., with medical staff, club educators, territorial and community agencies in charge of recreational areas and transportation infrastructures).</p>
</sec>
<sec>
<title>Effectiveness of interventions</title>
<p>Two studies targeted 2 levels (interpersonal and organizational), and all (100%) had high methodological quality (i.e., score equal to or higher than 8). Then, 19 studies targeting 3 levels (mainly intrapersonal, interpersonal and organizational), of which 14 (74%) had high methodological quality. Last, 9 trials used four-level strategies (i.e., intra-, interpersonal, organizational and community-based), of which 2 (22%) showed high quality, and 7 (78%) a lower quality score. No study achieved to target the macro-environment or public policies level (e.g., social and cultural norms via media, urban planning, transport system).</p>
<p>Effectiveness on sedentary outcomes was analyzed according to the number of levels targeted by the intervention, based on the socio-ecological model level stratification (see <xref ref-type="fig" rid="F2">Figure 2</xref>). A trial was considered as effective when the study reported a significant impact of intervention on a sedentary measure at post- vs. pre-intervention; if several sedentary measures were reported and at least one showed a significant decrease of ST, the study was classified as effective.</p>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption><p>Number of interventions respectively reporting effectiveness and non-effectiveness on sedentary outcome, according to the number of levels targeted.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpubh-11-1106206-g0002.tif"/>
</fig>
<p>As shown in the <xref ref-type="fig" rid="F2">Figure 2</xref>, 1 (50%) of studies targeting 2 levels, 9 (47%) that targeted 3 levels and 7 (78%) trials that targeted 4 levels of intervention, were effective in reducing ST-SB.</p>
<p><xref ref-type="table" rid="T3">Table 3</xref> summarizes, for each trial, the effectiveness according to the number and type of levels targeted and to the methodological quality score.</p>
<table-wrap position="float" id="T3">
<label>Table 3</label>
<caption><p>Effectiveness on ST-SB of trials according to methodological quality score, number and type of interventional levels targeted (as defined by the socio-ecological model).</p></caption> 
<table frame="box" rules="all">
<thead>
<tr style="background-color:&#x00023;919498;color:&#x00023;ffffff">
<th valign="top" align="left" rowspan="3"><bold>Number of levels targeted</bold></th>
<th valign="top" align="left" rowspan="3"><bold>Type of Levels targeted</bold></th>
<th valign="top" align="center" colspan="4"><bold>Methodological quality score</bold></th>
</tr>
<tr style="background-color:&#x00023;919498;color:&#x00023;ffffff">
<th valign="top" align="center" colspan="2">&#x02265;<bold>8</bold></th>
<th valign="top" align="center" colspan="2">&#x0003C;<bold>8</bold></th>
</tr>
<tr style="background-color:&#x00023;919498;color:&#x00023;ffffff">
<th valign="top" align="left"><bold>Effectiveness on ST-SB</bold></th>
<th valign="top" align="left"><bold>No effectiveness</bold></th>
<th valign="top" align="left"><bold>Effectiveness on ST-SB</bold></th>
<th valign="top" align="left"><bold>No effectiveness</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">2</td>
<td valign="top" align="left">Interpersonal and organizational</td>
<td valign="top" align="left"><italic>N =</italic> 1 Engelen et al. (<xref ref-type="bibr" rid="B38">38</xref>)</td>
<td valign="top" align="left"><italic>N =</italic> 1 Ni-Mhurchu et al. (<xref ref-type="bibr" rid="B59">59</xref>)</td>
<td/>
<td/>
</tr> <tr>
<td valign="top" align="left">3</td>
<td valign="top" align="left">Intrapersonal, interpersonal and organizational</td>
<td valign="top" align="left"><italic>N =</italic> 6 Carson et al. (<xref ref-type="bibr" rid="B33">33</xref>); Kipping et al. (<xref ref-type="bibr" rid="B50">50</xref>, <xref ref-type="bibr" rid="B84">84</xref>); Subg: Kobel et al. (<xref ref-type="bibr" rid="B55">55</xref>)<sup>a</sup>; Nyberg et al. (<xref ref-type="bibr" rid="B60">60</xref>)<sup>b</sup>; Salmon et al. (<xref ref-type="bibr" rid="B64">64</xref>)<sup>b</sup></td>
<td valign="top" align="left"><italic>N =</italic> 7 Escobar-Chaves et al. (<xref ref-type="bibr" rid="B40">40</xref>); Elder et al. (<xref ref-type="bibr" rid="B36">36</xref>); Harrison et al. (<xref ref-type="bibr" rid="B47">47</xref>); Lynch et al. (<xref ref-type="bibr" rid="B56">56</xref>); Pablos et al. (<xref ref-type="bibr" rid="B62">62</xref>); Verloigne et al. (<xref ref-type="bibr" rid="B75">75</xref>); Vik et al. (<xref ref-type="bibr" rid="B75">75</xref>)</td>
<td valign="top" align="left"><italic>N =</italic> 3 French et al. (<xref ref-type="bibr" rid="B43">43</xref>); Taylor et al. (<xref ref-type="bibr" rid="B70">70</xref>); Todd et al. (<xref ref-type="bibr" rid="B71">71</xref>)</td>
<td valign="top" align="left"><italic>N =</italic> 2 Duncan et al. (<xref ref-type="bibr" rid="B35">35</xref>); Pearson et al. (<xref ref-type="bibr" rid="B63">63</xref>)</td>
</tr> <tr>
<td valign="top" align="left">3</td>
<td valign="top" align="left">Interpersonal, organizational and community</td>
<td/>
<td valign="top" align="left"><italic>N =</italic> 1 Elder et al. (<xref ref-type="bibr" rid="B37">37</xref>)</td>
<td/>
<td/>
</tr> <tr>
<td valign="top" align="left">4</td>
<td valign="top" align="left">Intrapersonal, Interpersonal, organizational and community</td>
<td valign="top" align="left"><italic>N =</italic> 2 Simon et al. (<xref ref-type="bibr" rid="B66">66</xref>); subg: Madsen et al. (<xref ref-type="bibr" rid="B57">57</xref>)<sup>c</sup></td>
<td/>
<td valign="top" align="left"><italic>N =</italic> 5 Breslin et al. (<xref ref-type="bibr" rid="B32">32</xref>); Elder et al. (<xref ref-type="bibr" rid="B36">36</xref>); Folta et al. (<xref ref-type="bibr" rid="B41">41</xref>); Gentile et al. (<xref ref-type="bibr" rid="B45">45</xref>); Van Kann et al. (<xref ref-type="bibr" rid="B72">72</xref>); on subg: Wright et al. (<xref ref-type="bibr" rid="B80">80</xref>)<sup>b</sup></td>
<td valign="top" align="left"><italic>N =</italic> 2 Kattelmann et al. (<xref ref-type="bibr" rid="B48">48</xref>); Van Stralen et al. (<xref ref-type="bibr" rid="B73">73</xref>)</td>
</tr></tbody>
</table>
<table-wrap-foot>
<p><sup>a</sup>Gender and background migration; <sup>b</sup>gender; <sup>c</sup>grade.</p>
</table-wrap-foot>
</table-wrap>
<p>As presented in <xref ref-type="table" rid="T2">Table 2</xref>, among the trials that used a 2-levels based intervention, all (<italic>N</italic> = 2, 100%) having high methodological quality, 1 (50%) was effective in reducing ST-SB. Among the high (<italic>N</italic> = 14) and the acceptable (<italic>N</italic> = 5) quality studies of the 3-levels trials, 6 (43%) and 3 (60%) were effective, respectively. Lastly, among the 2 high-quality and the 7 lower quality score interventions that used a four-level strategy, 2 (100%), and 5 (71%) were effective, respectively.</p>
<p>Regarding high quality studies, 9 (50%) reported effectiveness on ST-SB, and among those, 1 included 2-level, 6 involved 3-level, and 2 presented 4-level based interventions. Regarding lower quality studies, 8 (67%) reported effectiveness on ST-SB, and among those, none included 2-level, 3 involved 3-level, and 5 presented 4-level based interventions.</p>
<p>The second aim of our review was to consider the involvement, and the degree of involvement of caregivers or social support close to the child (involvement is reported in <xref ref-type="table" rid="T2">Table 2</xref>). Involvement was considered as strong when the stakeholder had an active role (e.g., a teacher-lead intervention during school class), and weak when only passive (e.g., parent receiving a newsletter with information about ST). Among the 22 studies targeting parents as social support with a strong or active involvement, 10 (45%) were effective in reducing ST-SB; among the 5 studies that targeted parents with a more passive strategy, 4 (80%) have reported effectiveness; in 3 of these trials, teachers, community members and recreational centers directors were also, and strongly, involved. Above the 30 included interventions, implication of parents is often associated with an involvement of educational stakeholders (e.g., teachers, educators in health promotion, educational staff, recreational directors, nurses). Among the 17 effective trials that considered social support as an intervention strategy, 2 (12%) involved parents only; 3 (18%) involved educational stakeholders only and 11 (70%) involved both parents and caregivers from the educational environment, one involving parents and community stakeholders.</p>
<p>Finally, among the 21 studies involving educational stakeholders (e.g., teachers, educators in health promotion, educational staff, recreational directors, nurses) with a strong or active involvement, 13 (62%) were effective in reducing ST-SB; among the 5 studies that included weaker involvement of educational stakeholders, 1 (20%) has reported effectiveness.</p>
</sec>
</sec>
<sec sec-type="discussion" id="s4">
<title>Discussion</title>
<p>An important part of the scientific literature states that health behaviors linked with SB are influenced by intrapersonal factors, but also interpersonal and environmental determinants (<xref ref-type="bibr" rid="B11">11</xref>, <xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B17">17</xref>). Consequently, socio-ecological models and structural perspectives are drawing the attention of researchers (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B87">87</xref>). On a practical level, the combination of agentic and structural approach is operationalized by multi-level interventions that target multiple determinants, and use strategies at several levels of influence.</p>
<p>The purpose of this systematic review of the literature was to study and critically summarize controlled multilevel trials (i.e., targeting at least two levels of intervention) aiming to reduce SB (e.g., specific SB as TV-viewing, general ST), as primary or secondary outcome (e.g., it could first targeted PA) in young populations (children, from 5 to 12 years-old), and evaluate their effectiveness in relation to the number and the type of levels targeted (i.e., intrapersonal, interpersonal, organizational, and community), the methodological quality and the strategies (e.g., informational, behavioral, involving family and teachers) used in each level. To our knowledge, this is the first review that targets multilevel interventions specifically aiming for sedentary outcomes.</p>
<sec>
<title>Main findings</title>
<p>Final review included 30 controlled studies (most of them were published in the last decade) that involve 2, 19, and 9 interventions targeting 2, 3, and 4 different levels, respectively. Most of the included studies showed a high methodological quality score. However, in line with previous findings (<xref ref-type="bibr" rid="B22">22</xref>, <xref ref-type="bibr" rid="B23">23</xref>, <xref ref-type="bibr" rid="B30">30</xref>), the characteristics of included studies were heterogeneous, regarding the duration of the intervention (pilot studies had a shorter duration), population characteristics (e.g., size, age range, socioeconomic profile), settings (e.g., home, recreational center, school), assessment methods of ST-SB (i.e., subjective, objective, a combination of both measures), interventional strategies raised, leading to a difficulty to draw clear conclusions regarding the strategies and components that could preferentially reduce ST in children. Very few studies targeted 2 levels of intervention, also resulting in difficulty to make strong conclusions and to allow meaningful comparisons between 2-levels trials and other multilevel (i.e., 3- and 4-levels) studies. Most of the included multi-level interventions targeted 3 levels, mainly intrapersonal factors, interpersonal or social support level and organizational level (e.g., school, home). As young populations usually spend most of their time at school, this institution is a critical and major setting of interventions. Some interventions involved the community level, but none included study has achieved to target the society level (macro-environment).</p>
<p>Regarding effectiveness to reduce SB in children, effectiveness was reported in 1 (50%), 9 (47%) and 7 (78%) interventions targeting 2, 3, and 4 levels, respectively. Results suggest that interventions could be more often effective when the strategies used are deployed along 4 levels. However, only two studies used a 2-level strategy, providing insufficient evidence to rigorously conclude, and more than 70% of the 3-level studies have a high quality, whereas the majority of 4-level trials (78%) has an acceptable methodological quality.</p>
<p>This review secondly aimed to consider the involvement of caregivers in the effectiveness of trials. Again, the low number of trials and the heterogeneity of the interventions does not allow to drive specific and clear conclusions and, therefore, to answer this question. However, it seems that an involvement of caregivers (parents but also educational stakeholders, teachers in particular) could be a relevant strategy, targeting the entire social support of children. This design is based on the assumption that having a supportive family environment can promote the targeted behavior change and be effective in reducing children&#x00027;s ST. In this study, results show that among effective trials that considered social support as an intervention strategy, most of them (70%) involved both parents and educational caregiver or community members and among the studies strongly involving educational stakeholders, 62% were effective in reducing ST-SB.</p>
<p>Results ultimately suggest that the key ingredients of a successful intervention may involve a combination of several components: (i) at the intrapersonal level, both behavioral (e.g., setting screen-time goals) and informational strategies (e.g., often in the regular curriculum of the child), (ii) at the interpersonal level, a supportive and highly involved social circle by including teachers and parents, (iii) at the organizational level, targeting several child&#x00027;s environments (school and home) and (iv) at a community level including stakeholders (e.g., partnership with local sport clubs, local municipalities).</p>
</sec>
<sec>
<title>Limitations and perspectives</title>
<p>Limitations of this work could be mentioned. First of all, a meta-analysis would have led to strongest conclusion. However, as previously raised, trials of very different nature met the inclusion criteria and were included and reviewed. Given the large heterogeneity in study design and intervention&#x00027;s characteristics, strong and relevant comparisons and analyses were difficult and it appeared that a meta-analysis was not relevant. This work also raised some methodological issues. The systemic approach proposed by the socio-ecological model is promising (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B13">13</xref>), but also intimidating, integrating and conceptualizing different levels of the environment. Therefore, a challenge still remains in the <italic>operationalization</italic> of this model, such that <italic>socio-ecological</italic> is not a &#x0201C;buzzword&#x0201D; in public health (<xref ref-type="bibr" rid="B19">19</xref>), and in finding the methods for assessing the degree of integration of the socio-ecological model into research (<xref ref-type="bibr" rid="B87">87</xref>&#x02013;<xref ref-type="bibr" rid="B89">89</xref>).</p>
<p>Future studies should analyze the impact of their intervention on ST-SB by specifying the type of SB (e.g., time spent reading, watching TV) and context (e.g., location or social situation). It is highly unlikely that a reduction in a specific SB will be directly replaced with PA; actually, it has a greater chance to be allocated to other SB (<xref ref-type="bibr" rid="B21">21</xref>, <xref ref-type="bibr" rid="B22">22</xref>, <xref ref-type="bibr" rid="B90">90</xref>).</p>
<p>When subjective assessments are used, different types of SB should be taken into account and lead to a comparison between different distinct behaviors (e.g., computer time vs. screen time) targeted by interventions (<xref ref-type="bibr" rid="B22">22</xref>). Domain-specific SB should be identified, with, as suggested by Owen et al. (<xref ref-type="bibr" rid="B13">13</xref>), a consideration of passive (e.g., TV viewing) vs. mentally active (e.g., reading, computer use) SB. Future trials should target other types of sedentary behavior, including non-screen-based measures, and consider the recent technological changes (<xref ref-type="bibr" rid="B3">3</xref>), given that this last decade, the use of small screens, as smartphones and tablets, is increasing in children.</p>
<p>In addition to the identification of domain-specific SB, there is a growing need to operationalize the distinction between passive (e.g., TV viewing) vs. mentally active (e.g., reading, computer use) SB (<xref ref-type="bibr" rid="B13">13</xref>). Moreover, the challenge of school-based interventions, even when they include home activities or home components in their strategies, is to reduce ST both at school and out of school. Another perspective thus concerns the need to interrupt ST during the whole day, as pointed out in the literature (<xref ref-type="bibr" rid="B30">30</xref>, <xref ref-type="bibr" rid="B91">91</xref>, <xref ref-type="bibr" rid="B92">92</xref>) and in the latest worldwide guidelines (<xref ref-type="bibr" rid="B5">5</xref>).</p>
<p>Targeting intrinsic levers in intervention strategies is important as only focusing on the environment of the child is not enough, considering that young people tend to select sedentary activities, even when physically active alternatives are available (<xref ref-type="bibr" rid="B22">22</xref>, <xref ref-type="bibr" rid="B90">90</xref>, <xref ref-type="bibr" rid="B93">93</xref>). On the other hand, targeting intrapersonal determinants to the detriment of the broader environment and of structural and political changes is an incomplete strategy. Future studies should use ecologic approach -e.g., targeting norms, physical components-, with a strong and active involvement of caregivers (social support) in the various environments (e.g., school staff, parents at home) of the child, in addition to curriculum or behavioral punctual strategies. Multilevel or socio-ecologic interventions should involve community level and the broader environment, as none included study has achieved to target the society level.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>A paradigmatic shift is occurring in the literature, and interventions targeting health behaviors are more and more multi-level or socio-ecological based. To our knowledge, no study had systematically reviewed and assessed the effectiveness of multilevel controlled trials targeting ST-SB in young (5&#x02013;12 years) populations. Our findings show that more than half of the included interventions based on socioecological model (i.e., multilevel) have reported effectiveness of children SB. Indeed, among included studies, effectiveness on children SB was reported in 50%, 47%, and 78% interventions targeting 2, 3, and 4 levels, respectively. Therefore, results suggest that interventions could be more often effective when the strategies used are deployed along 4 levels. In addition, it seems that targeting four different levels i.e., intrapersonal, interpersonal, organizational and community, tend to led to more successful interventions to reduce SB.</p>
<p>This review highlights the need for additional randomized controlled trials evaluating multilevel interventions targeting ST-SB in young populations. More studies designing and implementing multilevel interventions are needed to &#x0201C;address the gap between theory and practice&#x0201D; (<xref ref-type="bibr" rid="B19">19</xref>) and remove operational and empirical hurdles. In addition, more reviews and meta-analyses are required to clearly assess their effectiveness and the key strategies underlying their effectiveness. Also, a theoretical and methodological reflection to quantify the degree of integration of the socioecological model in studies has to be continued to correctly evaluate the socio-ecological perspective.</p>
</sec>
</sec>
<sec sec-type="data-availability" id="s5">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="author-contributions" id="s6">
<title>Author contributions</title>
<p>MC-G selected eligible studies and assessed the inclusion criteria to determine preliminary eligibility of studies based on the title and/or the abstract. Following the PRISMA guidelines, MC-G applied the PICOS method to check if the data fit the following inclusion criteria. MC-G and MC separately read the full text, using the inclusion PICOS criteria to assess the final inclusion of articles. Any discrepancies were discussed until consensus was reached. MC-G and SL extracted relevant data including methodology, participants, outcomes, and results. CD brought his expertise to this work and ensured the overall review of the manuscript. All authors contributed to the article and approved the submitted version.</p>
</sec>
</body>
<back>
<sec sec-type="funding-information" id="s7">
<title>Funding</title>
<p>This work was supported by the French Institut National du Cancer (INCa project grant PREV19-021, INCA_14185).</p>
</sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s8">
<title>Publisher&#x00027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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