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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Public Health</journal-id>
<journal-title>Frontiers in Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Public Health</abbrev-journal-title>
<issn pub-type="epub">2296-2565</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpubh.2021.742012</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health</subject>
<subj-group>
<subject>Mini Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Voice-Activated Virtual Home Assistant Use and Social Isolation and Loneliness Among Older Adults: Mini Review</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Corbett</surname> <given-names>Cynthia F.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1279096/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Wright</surname> <given-names>Pamela J.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1427449/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Jones</surname> <given-names>Kate</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Parmer</surname> <given-names>Michael</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>College of Nursing, University of South Carolina</institution>, <addr-line>Columbia, SC</addr-line>, <country>United States</country></aff>
<aff id="aff2"><sup>2</sup><institution>Advancing Chronic Care Outcomes through Research and Innovation Center, College of Nursing, University of South Carolina</institution>, <addr-line>Columbia, SC</addr-line>, <country>United States</country></aff>
<aff id="aff3"><sup>3</sup><institution>Prisma Health Senior Care Program for All-Inclusive Care for the Elderly</institution>, <addr-line>Greenville, SC</addr-line>, <country>United States</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Marcia G. Ory, Texas A&#x00026;M University, United States</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Deborah Vollmer Dahlke, Texas A&#x00026;M School of Public Health, United States; Patricia M. Alt, Towson University, United States</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Cynthia F. Corbett <email>corbett&#x00040;sc.edu</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Aging and Public Health, a section of the journal Frontiers in Public Health</p></fn></author-notes>
<pub-date pub-type="epub">
<day>11</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="collection">
<year>2021</year>
</pub-date>
<volume>9</volume>
<elocation-id>742012</elocation-id>
<history>
<date date-type="received">
<day>15</day>
<month>07</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>23</day>
<month>09</month>
<year>2021</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2021 Corbett, Wright, Jones and Parmer.</copyright-statement>
<copyright-year>2021</copyright-year>
<copyright-holder>Corbett, Wright, Jones and Parmer</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license> </permissions>
<abstract><p>A lack of social connectedness is common among older adults due to living alone, loss of loved ones, reduced mobility, and, more recently, social distancing created by the global Covid-19 pandemic. Older adults are vulnerable to social isolation and loneliness, which pose significant health risks comparable to those of smoking, obesity, physical inactivity, and high blood pressure. A lack of social connectedness is also correlated with higher mortality rates even when controlling for other factors such as age and comorbid conditions. The purpose of this mini review was to explore the emerging concepts of older adults&#x00027; use of commercially available artificial intelligent virtual home assistants (VHAs; e.g., Amazon Echo, Google Nest), and its relationship to social isolation and loneliness. A secondary purpose was to identify potential areas for further research. Results suggest that VHAs are perceived by many older adult users as &#x0201C;companions&#x0201D; and improve social connectedness and reduce loneliness. Available studies are exploratory and descriptive and have limited generalizability due to small sample sizes, however, similar results were reported across several studies conducted in differing countries. Privacy concerns and other ethical issues and costs associated with VHA use were identified as potential risks to older adults&#x00027; VHA adoption and use. Older adults who were using VHAs expressed the need and desire for more structured training on device use. Future research with stronger methods, including prospective, longitudinal, and randomized study designs are needed. Public education, industry standards, and regulatory oversight is required to mitigate potential risks associated with VHA use.</p></abstract>
<kwd-group>
<kwd>virtual home assistant</kwd>
<kwd>conversational assistant</kwd>
<kwd>voice-activated speaker</kwd>
<kwd>social connectedness</kwd>
<kwd>social isolation</kwd>
<kwd>loneliness</kwd>
<kwd>older adults</kwd>
<kwd>geriatric (aging)</kwd>
</kwd-group>
<counts>
<fig-count count="0"/>
<table-count count="2"/>
<equation-count count="0"/>
<ref-count count="42"/>
<page-count count="6"/>
<word-count count="5212"/>
</counts>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="s1">
<title>Introduction</title>
<p>Social isolation and loneliness are serious public health concerns that affect a significant portion of the older adult population. The National Health and Aging Trends Study indicated that 24% of all community-dwelling adults aged 65 and older in the United States (US) were socially isolated (<xref ref-type="bibr" rid="B1">1</xref>). The National Health and Retirement Study revealed that 43% of US adults aged 60 and older report loneliness (<xref ref-type="bibr" rid="B2">2</xref>). Authors of a study in Germany, reported 30% of the participants expressed feeling lonely 1&#x02013;3 times per month (<xref ref-type="bibr" rid="B3">3</xref>). Older adults are often at risk for social isolation and loneliness due to factors such as living alone, loss of loved ones, reduced mobility, vision, and hearing deficits, and, recently, the necessity for social distancing due to the Covid-19 pandemic (<xref ref-type="bibr" rid="B4">4</xref>). Social disconnectedness is correlated with higher mortality rates even when controlling for other factors such as age and comorbid conditions. Meta-analysis findings revealed social isolation and loneliness elevate mortality risk by 26&#x02013;32%, similar in magnitude to that of established risk factors, such as smoking, obesity, physical inactivity, and high blood pressure (<xref ref-type="bibr" rid="B5">5</xref>). Social isolation or loneliness in older adults has also been associated with a 50% increased risk of dementia (<xref ref-type="bibr" rid="B6">6</xref>) and a 30% increased risk of coronary artery disease (<xref ref-type="bibr" rid="B7">7</xref>).</p>
<p>Social connection describes the structural, functional, and quality aspects of human relationships and interactions (<xref ref-type="bibr" rid="B8">8</xref>). Social isolation is the objective lack or limited extent of social connection with others. Loneliness is the subjective feeling of being lonely. Socially isolated people may not feel lonely, and, contrarily, persons with many social connections may express loneliness (<xref ref-type="bibr" rid="B9">9</xref>). Typically, social support functions to provide emotional, tangible, informational, and/or companionship assistance to improve social connection (<xref ref-type="bibr" rid="B8">8</xref>). Unfortunately, traditional social supports may not always be available. Although many social support interventions have been implemented in community organizations, participation by older adults may be limited by access, cost, mobility, and/or interest (<xref ref-type="bibr" rid="B8">8</xref>). The emergence of artificial intelligence (AI) may offer unprecedented opportunities to relieve social isolation and loneliness among older adults to improve health outcomes.</p>
<p>Artificial intelligence describes algorithms that emulate human cognitive and behavioral processes and are installed into software programs of various platforms connected to the internet (<xref ref-type="bibr" rid="B10">10</xref>). Conversational agents are one such platform, whereby a device automatically processes and responds to human voice and language. Through natural language processing and machine learning, conversational agents interpret questions and respond with messages using a simulated human tone (<xref ref-type="bibr" rid="B11">11</xref>). With increased online data availability and technological advances, commercially available VHAs have been marketed by companies such as Amazon (i.e., Echo/&#x0201C;Alexa&#x0201D;) and Google (i.e., Google Nest) for about 6 years. Commercially available voice-activated virtual home assistants (VHAs) are relatively inexpensive and may be particularly useful for older adults who have less technological literacy or vision or fine motor limitations.</p>
<p>Virtual home assistant users can listen to music, ask for information, and set reminders (<xref ref-type="bibr" rid="B12">12</xref>). Virtual home assistants also offer a range of applications or &#x0201C;skills&#x0201D; to engage users, such as games, that could serve as cognitive stimulation (<xref ref-type="bibr" rid="B13">13</xref>), mood enhancement (<xref ref-type="bibr" rid="B14">14</xref>), and relief from boredom (<xref ref-type="bibr" rid="B15">15</xref>). In addition to these common uses, VHAs offer a promising technology to provide social connectivity through video calling and surrogate companionship in a manner that addresses social isolation and helps relieve loneliness. The purpose of this mini review was to explore research findings on older adults&#x00027; VHA use and its potential relationship to social isolation and loneliness.</p></sec>
<sec sec-type="materials and methods" id="s2">
<title>Materials and Methods</title>
<sec>
<title>Data Sources</title>
<p>A mini review was conducted to identify the current state of the science on older adults&#x00027; VHA use and its potential relationship to social isolation and loneliness. Specific search terms were created for social isolation, loneliness, and older adults. However, as relatively new devices, no common electronic database terms for VHAs were identified. Thus, a variety of terms, including voice assistants, virtual assistants, and conversational agents were used in the searches. The search strategy was based on the recommended practice of each selected electronic database (PubMed, CINAHL, PsycInfo, Compendex) using a combination of sililar terms (<xref ref-type="table" rid="T1">Table 1</xref>).</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p>Concepts with MeSH and TIAB terms used for PubMed search.</p></caption>
<table frame="hsides" rules="groups">
<thead><tr>
<th valign="top" align="left"><bold>Construct/concept</bold></th>
<th valign="top" align="left"><bold>Mesh term</bold></th>
<th valign="top" align="left"><bold>TIAB term</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Voice-activated virtual home assistant</td>
<td valign="top" align="left">Ambient (sensors), artificial intelligence, deep learning, voice[&#x02013;]activated virtual assistants, <bold>conversational agents</bold>, social support agents</td>
<td valign="top" align="left">Alexa, Google Home, Google Nest, Amazon Echo, digital assistant, virtual assistant, voice activated assistant, VHA</td>
</tr>
<tr>
<td valign="top" align="left">Social isolation</td>
<td valign="top" align="left">Isolation, social (use this word to find terms similar to &#x0201C;social isolation&#x0201D;), social exclusion,<break/> social alienation</td>
<td valign="top" align="left">COVID, social isolation, loneliness, social exclusion, social connectedness</td>
</tr>
<tr>
<td valign="top" align="left">Loneliness</td>
<td valign="top" align="left">Loneliness, depression, geriatric psychiatry</td>
<td valign="top" align="left">Social connectedness</td>
</tr>
<tr>
<td valign="top" align="left">Older adults</td>
<td valign="top" align="left">Older adults, gerontology, geriatrics</td>
<td valign="top" align="left">Grandparents, elderly, aging in place</td>
</tr>
</tbody>
</table>
</table-wrap></sec>
<sec>
<title>Data Selection and Extraction</title>
<p>Articles were deemed eligible for review if they were published in a peer-reviewed journal, written in English, addressed a concept related to social isolation or loneliness, and involved older adults&#x00027; use of a commercially available VHA. Each eligible article was independently appraised based on inclusion and exclusion criteria by our team. Following title and abstract, the search yielded only four articles, and none were retained following full article review. Thus, the articles evaluated in this mini review were gleaned from the authors&#x00027; reference libraries (<italic>n</italic> = 6) and article reference searches (<italic>n</italic> = 1).</p></sec></sec>
<sec sec-type="results" id="s3">
<title>Results</title>
<sec>
<title>Study Characteristics</title>
<p>Study designs of the research included in this mini review were descriptive and used convenience samples. Except for one study (<xref ref-type="bibr" rid="B3">3</xref>), findings are based on qualitative content analysis. Of the seven studies, five used prospective methods and two were retrospective analyses of publicly available consumer reviews of VHAs (<xref ref-type="table" rid="T2">Table 2</xref>). The five prospective descriptive studies enrolled older adults who had not previously used VHAs and had small sample sizes. One study reported findings from 30 participants; however, not all participants were older adults (<xref ref-type="bibr" rid="B3">3</xref>). Another study included older adults (<italic>n</italic> = 10) and their respective support persons (<italic>n</italic> = 9) (<xref ref-type="bibr" rid="B12">12</xref>). All other sample sizes in the prospective studies included 7&#x02013;12 older adult participants (aged 65&#x02013;95 years). Study duration ranged from 3 weeks to 18 months. Amazon devices were used in four and Google devices in one of the prospective studies. The secondary analyses of consumer reviews reported user findings from Amazon Echo devices (<xref ref-type="bibr" rid="B13">13</xref>) and from Xiaomi XiaoAI, a VHA available in China (<xref ref-type="bibr" rid="B16">16</xref>).</p>
<table-wrap position="float" id="T2">
<label>Table 2</label>
<caption><p>VHA study characteristics.</p></caption>
<table frame="hsides" rules="groups">
<thead><tr>
<th valign="top" align="left"><bold>Primary Author, Year</bold></th>
<th valign="top" align="left"><bold>Study design</bold></th>
<th valign="top" align="left"><bold>Sample</bold></th>
<th valign="top" align="left"><bold>Participant ages</bold></th>
<th valign="top" align="left"><bold>Study duration</bold></th>
<th valign="top" align="left"><bold>Device</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Chambers, 2020</td>
<td valign="top" align="left">Prospective</td>
<td valign="top" align="left"><italic>n</italic> = 30 adults with chronic health conditions</td>
<td valign="top" align="left">Not reported</td>
<td valign="top" align="left">&#x02265;2 months</td>
<td valign="top" align="left">Echo Show</td>
</tr>
<tr>
<td valign="top" align="left">Chung, 2021</td>
<td valign="top" align="left">Retrospective</td>
<td valign="top" align="left"><italic>n</italic> = 320 consumer reviews from verified buyers, 2018</td>
<td valign="top" align="left">Not reported</td>
<td valign="top" align="left">N/A</td>
<td valign="top" align="left">Xiaomi XiaoAI</td>
</tr>
<tr>
<td valign="top" align="left">Corbett, 2021</td>
<td valign="top" align="left">Prospective</td>
<td valign="top" align="left"><italic>n</italic> = 19</td>
<td valign="top" align="left">Older adults (<italic>n</italic> = 10) 70 and older (X = 75); support persons (<italic>n</italic> = 9), (X = 53);</td>
<td valign="top" align="left">4 months</td>
<td valign="top" align="left">Echo Show and Dot (older adults), Echo Spot (support persons)</td>
</tr>
<tr>
<td valign="top" align="left">Kim, 2021</td>
<td valign="top" align="left">Prospective</td>
<td valign="top" align="left"><italic>n</italic> = 12</td>
<td valign="top" align="left">77&#x02013;95 years</td>
<td valign="top" align="left">4 months</td>
<td valign="top" align="left">Google Home</td>
</tr>
<tr>
<td valign="top" align="left">O&#x00027;Brien, 2020</td>
<td valign="top" align="left">Retrospective</td>
<td valign="top" align="left"><italic>n</italic> = 125 consumer reviews, 2015&#x02013;2018</td>
<td valign="top" align="left">Not reported</td>
<td valign="top" align="left">N/A</td>
<td valign="top" align="left">Amazon Echo</td>
</tr>
<tr>
<td valign="top" align="left">Pradhan, 2019</td>
<td valign="top" align="left">Prospective</td>
<td valign="top" align="left"><italic>n</italic> = 7</td>
<td valign="top" align="left">65&#x02013;83 years</td>
<td valign="top" align="left">3 weeks</td>
<td valign="top" align="left">Echo Dot</td>
</tr>
<tr>
<td valign="top" align="left">Scherr, 2020</td>
<td valign="top" align="left">Prospective</td>
<td valign="top" align="left"><italic>n</italic> = 11</td>
<td valign="top" align="left">68&#x02013;83 years</td>
<td valign="top" align="left">&#x02265;12 months</td>
<td valign="top" align="left">Echo Show</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>Chambers and Beaney (<xref ref-type="bibr" rid="B15">15</xref>); Chung and Woo (<xref ref-type="bibr" rid="B16">16</xref>); Corbett et al. (<xref ref-type="bibr" rid="B12">12</xref>); Kim and Choudhury (<xref ref-type="bibr" rid="B17">17</xref>); O&#x00027;Brien et al. (<xref ref-type="bibr" rid="B13">13</xref>); Pradhan et al. (<xref ref-type="bibr" rid="B18">18</xref>); Scherr et al. (<xref ref-type="bibr" rid="B3">3</xref>)</italic>.</p>
</table-wrap-foot>
</table-wrap></sec>
<sec>
<title>Social Isolation and Loneliness</title>
<p>Companionship was reported as a benefit for older adult VHA users in both consumer review studies. O&#x00027;Brien et al.&#x00027;s analysis of VHA consumer reviews was specific to older adults and companionship was one of five identified themes (<xref ref-type="bibr" rid="B13">13</xref>). Supporting quotes from the consumer reviews included: <italic>Echo now keeps me company and allows me to keep my brain active too. She is more than a great bit of electronics&#x02026;.she is also a companion for me</italic>. Chung and Woo&#x00027;s study analyzed comments from consumers of Xiaomi XiaoAI, were not specific to older adults (<xref ref-type="bibr" rid="B16">16</xref>). However, one theme noted by the investigators was the potential for VHA use to decrease loneliness and social isolation among older adult users, supported by the following consumer review: <italic>Having her [Xiaomi XiaoAI], I am no longer lonely</italic>.</p>
<p>The prospective studies (<italic>n</italic> = 5) identified companionship as a major finding. Chambers and Beaney&#x00027;s study provided VHAs to people who had health or dependence needs, of whom some were older adults (<xref ref-type="bibr" rid="B15">15</xref>). They reported that the participants who lived alone or were solitary for most of the day characterized the VHA as a source of companionship that reduced loneliness and improved mental health. Pradhan et al. conducted semi-structured interviews with older adult participants prior to installing the VHA devices in their homes and, after installation, conducted follow-up interviews every week for 3 weeks (<xref ref-type="bibr" rid="B18">18</xref>). One of their thematic findings was that the natural language processing and responsiveness of the VHA resulted in older adults perceiving the VHA as a friend. Supporting quotes included:</p>
<disp-quote><p>&#x02026;<italic>.when it talks, I don&#x00027;t see a box. I just see&#x02026;.It&#x00027;s like somebody is standing there talking to me&#x02026;.Somebody is here with me and they&#x00027;re having a conversation with me. It&#x00027;s making my day</italic>. [(<xref ref-type="bibr" rid="B18">18</xref>), p. 2].</p>
<p>&#x02026;<italic>And it answers me and I am talking to it, I could think of it as a person</italic>. [(<xref ref-type="bibr" rid="B18">18</xref>), p. 5].</p></disp-quote>
<p>Studies conducted by Corbett et al. (<xref ref-type="bibr" rid="B12">12</xref>) and Kim and Choudhury (<xref ref-type="bibr" rid="B17">17</xref>) placed VHAs in older adults&#x00027; homes for 4 months. Kim and Choudhury interviewed participants every other week during the study whereas Corbett et al. interviewed participants once at the end of the 4-month study. Similar findings about companionship were obtained from each study as exemplified below.</p>
<disp-quote><p><italic>I have humanized that machine. I call her a &#x02018;she&#x00027; and a &#x02018;her&#x00027; and every morning I say</italic>,</p></disp-quote>
<disp-quote><p>&#x02018;<italic>Alexa what is the weather going to be like?&#x00027; &#x02026;.I always report in every morning and every night and I just have a kinship with Alexa.&#x02026;. And you know, I know that&#x00027;s a machine&#x02026;[laughs] but it&#x00027;s just that I feel like it&#x00027;s somebody here with me</italic>. [(<xref ref-type="bibr" rid="B12">12</xref>), p. OA105].&#x0201C;<italic>I think it is really good. It&#x00027;s not as if you&#x00027;re talking to yourself. You&#x00027;re talking to somebody. It makes you feel like you&#x00027;re really not alone. You never have to be alone because you can talk to Google&#x0201D;</italic>. [(<xref ref-type="bibr" rid="B17">17</xref>), p. P8W8].</p></disp-quote>
<p>Authors of another study summarized the overall results from their study in a similar manner noting that Alexa had &#x0201C;<italic>become a beloved new roommate</italic>&#x0201D; for their participants. &#x0201C;Even though everyone knows that device is just a machine that can speak, for some of the participants it feels like an actual person that can reduce loneliness&#x0201D; [(<xref ref-type="bibr" rid="B3">3</xref>), p. 8].</p>
<p>Scherr et al. quantitatively measured loneliness and social isolation among their participants (<italic>n</italic> = 11) who were enrolled at least 12 months and lived within a defined neighborhood (<xref ref-type="bibr" rid="B3">3</xref>). Both individual and group interviews of participants were conducted. Group interviews allowed participants to interact with one another in person and exchange ideas about using the VHA. Every 3 months participants rated how often they felt lonely with response items that ranged from never to daily. Results indicated that participants reported reduced loneliness over time and reported increased social connectedness by using the VHA for video calling feature several times per week.</p></sec></sec>
<sec sec-type="discussion" id="s4">
<title>Discussion</title>
<sec>
<title>Main Findings</title>
<p>The purpose of this mini review was to synthesize knowledge about the potential relationship between older adults&#x00027; VHA use and the influence on social isolation and loneliness. The research findings were primarily based on qualitative content analysis. Quotes from several of the studies supported that the VHA reduced loneliness in many participants. Based on the findings of their study, Pradhan et al.&#x00027;s suggested participants&#x00027; interactions with the VHA reduced loneliness in the moment rather than alleviating a more global feeling of loneliness (<xref ref-type="bibr" rid="B18">18</xref>). However, Scherr et al. specifically measured both loneliness and social connectedness and reported participants improved in both areas over time (<xref ref-type="bibr" rid="B3">3</xref>).</p>
<p>All researchers in this mini review noted that the VHA provided a source of companionship for the users. &#x0201C;Companionship&#x0201D; is defined in the Meriam-Webster dictionary as &#x0201C;the good feeling that comes from being with someone else&#x0201D; (<xref ref-type="bibr" rid="B19">19</xref>) and &#x0201C;companion&#x0201D; is defined as &#x0201C;a person or animal you spend time with or enjoy being with&#x02026;sometimes used figuratively&#x0201D; (<xref ref-type="bibr" rid="B20">20</xref>). The exemplar quotes reflected that the human-sounding voice and the conversational qualities of a Virtual home assistant lead users to personify the VHA and view it as a companion. Similar findings were documented in other VHA literature (<xref ref-type="bibr" rid="B21">21</xref>&#x02013;<xref ref-type="bibr" rid="B24">24</xref>). Rubin et al. suggested that VHAs are inherently socially interactive because verbal prompting is required to activate the device (<xref ref-type="bibr" rid="B25">25</xref>). Other researchers reported that people in households of one or two people use VHAs more than those in larger households and attributed this finding to the social aspects of VHA use (<xref ref-type="bibr" rid="B26">26</xref>). Device placement in the home was also noted as important. The VHA may provide a human-like &#x0201C;presence&#x0201D; when the user is in the same room, but the feeling is reduced when the user is separated from the device (<xref ref-type="bibr" rid="B18">18</xref>).</p>
<p>To better understand VHA users&#x00027; behavior, Han and Yang tested whether users may develop parasocial relationships with their VHAs (<xref ref-type="bibr" rid="B27">27</xref>). Parasocial relationship theory was originally used to explain people&#x00027;s imaginary interpersonal relationships between themselves and media (e.g., radio, television) personalities. Han and Yang measured the three parasocial relationship concepts of task attraction (how easy or worthwhile the device is to use and its reliability to complete a task), physical attraction (the user&#x00027;s perception of the visual appearance of the VHA), and social attraction (the user&#x00027;s intention to communicate and make friends with the VHA) in a sample of younger VHA users (<italic>n</italic> = 304). Users&#x00027; social attraction to the VHA had four-fold greater impact on developing a positive parasocial relationship with the VHA than task attraction or physical attraction (<xref ref-type="bibr" rid="B27">27</xref>). Thus, their findings reinforce the importance of the human-like qualities of VHAs and provide insight into how people may develop the perception of the VHA as a companion, which may reduce loneliness.</p>
<p>Virtual home assistant capabilities that may reduce social isolation include providing information on news and current events, streaming religious services, and allowing voice and video calls to socially connect. Scherr et al. reported that many of their participants used the VHA at least several times per week for video calls (<xref ref-type="bibr" rid="B3">3</xref>). However, studies involving video calls to residents in long- term care facilities were inconclusive about the effect on social connectedness (<xref ref-type="bibr" rid="B28">28</xref>). Results of several studies in this mini review reported that participants liked the ease of using VHAs as compared to other technology, such as a mobile phone or computer (<xref ref-type="bibr" rid="B3">3</xref>, <xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B17">17</xref>), but also noted that older adult users desired more education and training about how to use it (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B17">17</xref>). Thus, providing more training on VHA features than was provided in most of the studies in this mini review may help older adults to more fully realize the potential of the devices to reduce social isolation and loneliness (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B17">17</xref>, <xref ref-type="bibr" rid="B29">29</xref>, <xref ref-type="bibr" rid="B30">30</xref>).</p></sec>
<sec>
<title>Methodological Findings</title>
<p>All studies included in this mini review were exploratory or descriptive with small ( &#x02264;30) sample sizes. Hence, the findings must be interpreted cautiously due to the voluntary, self-selected nature of the studies, and the lack of control groups. Further, only seven studies met the inclusion criteria, most of which were from the authors&#x00027; libraries. One explanation for the lack of results from the database search is that VHAs have only been on the market for about 7 years so research on this topic is relatively scant. In addition, the devices are referred to by a plethora of other names in the literature, including digital assistants, conversational agents, and smart speakers. Consequently, database indexes do not have a consistent keyword for the devices, which limits the utility of systematic searches. Findings across studies consistently noted that VHA use offered companionship to older adults and may reduce social isolation and loneliness. Nonetheless, the small number and methodological characteristics of the studies reviewed portray that the state of the science of older adults&#x00027; VHA use and its influence on social isolation and loneliness is in its infancy. Thus, there are many limitations to current knowledge, and the findings from the studies included in this mini review may not have adequately represented some of the risks and ethical controversies relevant to VHA use.</p></sec>
<sec>
<title>Personal and Ethical Considerations</title>
<p>The findings of this mini review noted potential benefits of VHAs, but there are also potential risks associated with VHAs. Privacy concerns, often noted as a barrier to VHA use (<xref ref-type="bibr" rid="B24">24</xref>, <xref ref-type="bibr" rid="B26">26</xref>, <xref ref-type="bibr" rid="B31">31</xref>), did not emerge as a theme in the studies included in this mini review, possibly attributed to self-selection bias. Older adults who had privacy concerns (e.g., VHA is &#x0201C;always listening&#x0201D;) probably declined to participate in the studies, whereas those who participated had minimal concerns about privacy. Technological advances and regulatory safeguards are needed to mitigate privacy threats from VHA use (<xref ref-type="bibr" rid="B11">11</xref>, <xref ref-type="bibr" rid="B24">24</xref>). The AI incorporated into VHAs is designed to mimic cognitive, emotional, and social intelligence, which contributes to the personification of VHAs (<xref ref-type="bibr" rid="B32">32</xref>) and to users viewing them as companions. Little is known about the eventual behavioral consequences of personifying a device (<xref ref-type="bibr" rid="B32">32</xref>), particularly when a person has cognitive impairment. Relatedly, an inability to remember the necessary commands to interact with a VHA may create frustration and agitation in people, particularly those with cognitive deficits (<xref ref-type="bibr" rid="B33">33</xref>). Conversely, AI is also being used to automate discourse analysis which may improve communication between people with dementia and their caregivers in the future (<xref ref-type="bibr" rid="B34">34</xref>). Concerns also exist about inequality and cultural and population biases built into technology-driven AI (<xref ref-type="bibr" rid="B35">35</xref>). For example, one study noted racial disparities in the automated speech recognition of VHAs (<xref ref-type="bibr" rid="B36">36</xref>). Alternatively, another study involving adults with intellectual disabilities had improvements in speech intelligibility after VHA interactions (<xref ref-type="bibr" rid="B37">37</xref>). Additionally, commercially available VHA devices are relatively affordable, but that benefit involves the risk of corporate-infused biases and targeted, personalized marketing opportunities (<xref ref-type="bibr" rid="B32">32</xref>), which may pose vulnerabilities for older adults. Virtual Home Assistant set-up and many functions require a smartphone and home internet access, which involves monthly costs. Taken together, the cost is prohibitive for some older adults (<xref ref-type="bibr" rid="B29">29</xref>). Thus, while the findings of the mini-review illustrate the potential benefits of VHAs for reducing social isolation and loneliness, there are also associated ethical considerations inherent to VHA use.</p></sec></sec>
<sec id="s5">
<title>Conclusions and Future Directions</title>
<p>Loneliness and social isolation are prevalent among older adults and pose serious health risks (<xref ref-type="bibr" rid="B5">5</xref>&#x02013;<xref ref-type="bibr" rid="B7">7</xref>, <xref ref-type="bibr" rid="B38">38</xref>). The results of this mini review suggest VHAs may offer a strategy to improve social connectedness and reduce loneliness for some older adults. A consistent finding was that many older adults perceived VHAs to be a companion. However, the state of the science is in its infancy. More research is needed to confirm these findings in larger, rigorously designed studies. Research is needed that quantitatively measures social isolation and loneliness outcomes among older adults using VHAs, as are studies that measure other known correlates to social isolation and loneliness, such as depressive symptoms (<xref ref-type="bibr" rid="B39">39</xref>), cognitive status (<xref ref-type="bibr" rid="B40">40</xref>), and functional ability (<xref ref-type="bibr" rid="B38">38</xref>). Additional research to define evidence-based strategies to teach VHA use skills to older adults is also needed. Ongoing refinements to the natural language processing features of VHAs to enhance the conversational experience will promote ease of use among older adults and improve the social attraction of the devices (<xref ref-type="bibr" rid="B17">17</xref>, <xref ref-type="bibr" rid="B21">21</xref>), which may strengthen perceptions of the devices as a companion and reduce social isolation and loneliness. However, research to better understand the risks and benefits of using VHAs and other AI-infused technology is required. Public awareness of the potential risks and benefits is necessary for older adult users and other vulnerable populations to make informed choices (<xref ref-type="bibr" rid="B35">35</xref>). Continued research, public involvement in product development, and policy to promote ethical, unbiased AI that protects the privacy of users is necessary (<xref ref-type="bibr" rid="B35">35</xref>). In addition, the growth of all types of digital health necessitates devising strategies for affordable and reliable internet access to promote health equity (<xref ref-type="bibr" rid="B41">41</xref>, <xref ref-type="bibr" rid="B42">42</xref>).</p></sec>
<sec id="s6">
<title>Author Contributions</title>
<p>CC formed the concept of the mini review and identified the included studies in this mini review. CC and PW completed the database search, reviewed the literature, and drafted the mini review. All authors reviewed and edited the mini review.</p></sec>
<sec sec-type="funding-information" id="s7">
<title>Funding</title>
<p>The University of South Carolina and the Advancing Chronic Care Outcomes through Research and Innovation Center provided partial support for this project.</p></sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec>
<sec sec-type="disclaimer" id="s8">
<title>Publisher&#x00027;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p></sec>
</body>
<back>
<ack><p>The authors are grateful to Sydney Reichardt for her assistance with the literature search and Khushi Patel for her assistance with formatting.</p>
</ack>
<ref-list>
<title>References</title>
<ref id="B1">
<label>1.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cudjoe</surname> <given-names>TKM</given-names></name> <name><surname>Roth</surname> <given-names>DL</given-names></name> <name><surname>Szanton</surname> <given-names>SL</given-names></name></person-group>. <article-title>The epidemiology of social isolation: national health and aging trends study</article-title>. <source>J Gerontol B Psychol Sci Soc Sci.</source> (<year>2020</year>) <volume>75</volume>:<fpage>107</fpage>&#x02013;<lpage>13</lpage>. <pub-id pub-id-type="doi">10.1093/geronb/gby037</pub-id><pub-id pub-id-type="pmid">29590462</pub-id></citation></ref>
<ref id="B2">
<label>2.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Perissinotto</surname> <given-names>CM</given-names></name> <name><surname>Stijacic Cenzer</surname> <given-names>I</given-names></name> <name><surname>Covinsky</surname> <given-names>KE</given-names></name></person-group>. <article-title>Loneliness in older persons a predictor of functional decline and death</article-title>. <source>Arch Intern Med</source>. (<year>2012</year>) <volume>172</volume>:<fpage>1078</fpage>&#x02013;<lpage>84</lpage>. <pub-id pub-id-type="doi">10.1001/archinternmed.2012.1993</pub-id><pub-id pub-id-type="pmid">22710744</pub-id></citation></ref>
<ref id="B3">
<label>3.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Scherr</surname> <given-names>SA</given-names></name> <name><surname>Meier</surname> <given-names>A</given-names></name> <name><surname>Cihan</surname> <given-names>S</given-names></name></person-group>. <article-title>Alexa tell me more &#x02013; about new best friends, the advantage of hands-free operation and life-long learning</article-title>. In: <source>Mensch und Computer 2020</source>. Magdeburg (<year>2020</year>). <pub-id pub-id-type="doi">10.18420/muc2020-ws120-342</pub-id></citation>
</ref>
<ref id="B4">
<label>4.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kotwal</surname> <given-names>AA</given-names></name> <name><surname>Holt-Lunstad</surname> <given-names>J</given-names></name> <name><surname>Newmark</surname> <given-names>RL</given-names></name> <name><surname>Cenzer</surname> <given-names>I</given-names></name> <name><surname>Smith</surname> <given-names>AK</given-names></name> <name><surname>Covinsky</surname> <given-names>KE</given-names></name> <etal/></person-group>. <article-title>Social isolation and loneliness among San Francisco Bay area older adults during the COVID-19 shelter-in-place orders</article-title>. <source>J Am Geriatr Soc.</source> (<year>2021</year>) <volume>69</volume>:<fpage>20</fpage>&#x02013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1111/jgs.16865</pub-id><pub-id pub-id-type="pmid">32965024</pub-id></citation></ref>
<ref id="B5">
<label>5.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Holt-Lunstad</surname> <given-names>J</given-names></name></person-group>. <article-title>The potential public health relevance of social isolation and loneliness: prevalence, epidemiology, and risk factors</article-title>. <source>Public Pol Aging Rep.</source> (<year>2017</year>) <volume>27</volume>:<fpage>127</fpage>&#x02013;<lpage>30</lpage>. <pub-id pub-id-type="doi">10.1093/ppar/prx030</pub-id></citation>
</ref>
<ref id="B6">
<label>6.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kuiper</surname> <given-names>JS</given-names></name> <name><surname>Zuidersma</surname> <given-names>M</given-names></name> <name><surname>Oude Voshaar</surname> <given-names>RC</given-names></name> <name><surname>Zuidema</surname> <given-names>SU</given-names></name> <name><surname>van den Heuvel</surname> <given-names>ER</given-names></name> <name><surname>Stolk</surname> <given-names>RP</given-names></name> <etal/></person-group>. <article-title>Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies</article-title>. <source>Ageing Res Rev.</source> (<year>2015</year>) <volume>22</volume>:<fpage>39</fpage>&#x02013;<lpage>57</lpage>. <pub-id pub-id-type="doi">10.1016/j.arr.2015.04.006</pub-id><pub-id pub-id-type="pmid">25956016</pub-id></citation></ref>
<ref id="B7">
<label>7.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Valtorta</surname> <given-names>NK</given-names></name> <name><surname>Kanaan</surname> <given-names>M</given-names></name> <name><surname>Gilbody</surname> <given-names>S</given-names></name> <name><surname>Ronzi</surname> <given-names>S</given-names></name> <name><surname>Hanratty</surname> <given-names>B</given-names></name></person-group>. <article-title>Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies</article-title>. <source>Heart.</source> (<year>2016</year>) <volume>102</volume>:<fpage>1009</fpage>&#x02013;<lpage>16</lpage>. <pub-id pub-id-type="doi">10.1136/heartjnl-2015-308790</pub-id><pub-id pub-id-type="pmid">27091846</pub-id></citation></ref>
<ref id="B8">
<label>8.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Donovan</surname> <given-names>NJ</given-names></name> <name><surname>Blazer</surname> <given-names>D</given-names></name></person-group>. <article-title>Social isolation and loneliness in older adults: review and commentary of a national academies report</article-title>. <source>Am J Geriatr Psychiatry.</source> (<year>2020</year>) <volume>28</volume>:<fpage>1233</fpage>&#x02013;<lpage>44</lpage>. <pub-id pub-id-type="doi">10.1016/j.jagp.2020.08.005</pub-id><pub-id pub-id-type="pmid">32919873</pub-id></citation></ref>
<ref id="B9">
<label>9.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Newall</surname> <given-names>NEG</given-names></name> <name><surname>Menec</surname> <given-names>VH</given-names></name></person-group>. <article-title>Loneliness and social isolation of older adults: why it is important to examine these social aspects together</article-title>. <source>J Soc Pers Relat.</source> (<year>2017</year>) <volume>36</volume>:<fpage>925</fpage>&#x02013;<lpage>39</lpage>. <pub-id pub-id-type="doi">10.1177/0265407517749045</pub-id></citation>
</ref>
<ref id="B10">
<label>10.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Schachner</surname> <given-names>T</given-names></name> <name><surname>Keller</surname> <given-names>R</given-names></name> <name><surname>von Wangenheim</surname> <given-names>F</given-names></name></person-group>. <article-title>Artificial intelligence-based conversational agents for chronic conditions: systematic literature review</article-title>. <source>J Med Internet Res.</source> (<year>2020</year>) <volume>22</volume>:<fpage>e20701</fpage>. <pub-id pub-id-type="doi">10.2196/20701</pub-id><pub-id pub-id-type="pmid">32924957</pub-id></citation></ref>
<ref id="B11">
<label>11.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>McGreevey</surname> <given-names>JD</given-names></name> <name><surname>Hanson</surname> <given-names>CW</given-names></name> <name><surname>Koppel</surname> <given-names>R</given-names></name></person-group>. <article-title>Clinical, legal, and ethical aspects of artificial intelligence-assisted conversational agents in health care</article-title>. <source>JAMA.</source> (<year>2020</year>) <volume>324</volume>:<fpage>552</fpage>&#x02013;<lpage>3</lpage>. <pub-id pub-id-type="doi">10.1001/jama.2020.2724</pub-id><pub-id pub-id-type="pmid">32706386</pub-id></citation></ref>
<ref id="B12">
<label>12.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Corbett</surname> <given-names>CF</given-names></name> <name><surname>Combs</surname> <given-names>EM</given-names></name> <name><surname>Wright</surname> <given-names>PJ</given-names></name> <name><surname>Owens</surname> <given-names>OL</given-names></name> <name><surname>Stringfellow</surname> <given-names>I</given-names></name> <name><surname>Nguyen</surname> <given-names>TP</given-names></name> <etal/></person-group>. <article-title>Virtual home assistant use and perceptions of usefulness by older adults and support person dyads</article-title>. <source>Intl J Environ Res Public Health.</source> (<year>2021</year>) <volume>18</volume>:<fpage>1113</fpage>. <pub-id pub-id-type="doi">10.3390/ijerph18031113</pub-id><pub-id pub-id-type="pmid">33513798</pub-id></citation></ref>
<ref id="B13">
<label>13.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>O&#x00027;Brien</surname> <given-names>K</given-names></name> <name><surname>Liggett</surname> <given-names>A</given-names></name> <name><surname>Ramirez-Zohfeld</surname> <given-names>V</given-names></name> <name><surname>Sunkara</surname> <given-names>P</given-names></name> <name><surname>Lindquist</surname> <given-names>LA</given-names></name></person-group>. <article-title>Voice-controlled intelligent personal assistants to support aging in place</article-title>. <source>J Am Geriatr Soc</source>. (<year>2020</year>) <volume>68</volume>:<fpage>176</fpage>&#x02013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1111/jgs.16217</pub-id><pub-id pub-id-type="pmid">31617581</pub-id></citation></ref>
<ref id="B14">
<label>14.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname> <given-names>BJ</given-names></name> <name><surname>Lim</surname> <given-names>MH</given-names></name></person-group>. <article-title>How the COVID-19 Pandemic is focusing attention on loneliness and social isolation</article-title>. <source>Public Health Res Pract.</source> (<year>2020</year>) <volume>30</volume>:<fpage>3022008</fpage>. <pub-id pub-id-type="doi">10.17061/phrp3022008</pub-id><pub-id pub-id-type="pmid">32601651</pub-id></citation></ref>
<ref id="B15">
<label>15.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chambers</surname> <given-names>R</given-names></name> <name><surname>Beaney</surname> <given-names>P</given-names></name></person-group>. <article-title>The potential of placing a digital assistant in patients&#x00027; homes</article-title>. <source>Br J Gen Pract.</source> (<year>2019</year>) <volume>70</volume>:<fpage>8</fpage>&#x02013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.3399/bjgp20X707273</pub-id><pub-id pub-id-type="pmid">31879289</pub-id></citation></ref>
<ref id="B16">
<label>16.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chung</surname> <given-names>S</given-names></name> <name><surname>Woo</surname> <given-names>BK</given-names></name></person-group>. <article-title>Using consumer perceptions of a voice-activated speaker device as an educational tool</article-title>. <source>JMIR Med Educ.</source> (<year>2020</year>) <volume>6</volume>:<fpage>e17336</fpage>. <pub-id pub-id-type="doi">10.2196/17336</pub-id><pub-id pub-id-type="pmid">32329740</pub-id></citation></ref>
<ref id="B17">
<label>17.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname> <given-names>S</given-names></name> <name><surname>Choudhury</surname> <given-names>A</given-names></name></person-group>. <article-title>Exploring older adults&#x00027; perception and use of smart speaker-based voice assistants: a longitudinal study</article-title>. <source>Comput Hum Behav</source>. (<year>2021</year>) <volume>124</volume>:<fpage>106914</fpage>. <pub-id pub-id-type="doi">10.1016/j.chb.2021.106914</pub-id></citation>
</ref>
<ref id="B18">
<label>18.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pradhan</surname> <given-names>A</given-names></name> <name><surname>Findlater</surname> <given-names>L</given-names></name> <name><surname>Lazar</surname> <given-names>A</given-names></name></person-group>. <article-title>&#x0201C;Phantom friend&#x0201D; or &#x0201C;just a box with information&#x0201D;: personification and ontological categorization of smart speaker-based voice assistants by older adults</article-title>. <source>Proc ACM Hum Comput Interact.</source> (<year>2019</year>) <volume>3</volume>:<fpage>1</fpage>&#x02013;<lpage>21</lpage>. <pub-id pub-id-type="doi">10.1145/3359316</pub-id></citation>
</ref>
<ref id="B19">
<label>19.</label>
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Merriam-Webster&#x00027;s</surname> <given-names>Learner&#x00027;s Dictionary</given-names></name></person-group>. <source>Companionship.</source> (<year>2021</year>). Available online at: <ext-link ext-link-type="uri" xlink:href="https://learnersdictionary.com/definition/companionship">https://learnersdictionary.com/definition/companionship</ext-link> (accessed July 12, 2021).</citation>
</ref>
<ref id="B20">
<label>20.</label>
<citation citation-type="web"><person-group person-group-type="author"><name><surname>Merriam-Webster&#x00027;s</surname> <given-names>Learner&#x00027;s Dictionary</given-names></name></person-group>. <source>Companion.</source> (<year>2021</year>). Available online at: <ext-link ext-link-type="uri" xlink:href="https://learnersdictionary.com/definition/companion">https://learnersdictionary.com/definition/companion</ext-link> (accessed July 12, 2021).</citation>
</ref>
<ref id="B21">
<label>21.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pradhan</surname> <given-names>A</given-names></name> <name><surname>Mehta</surname> <given-names>K</given-names></name> <name><surname>Findlater</surname> <given-names>L</given-names></name></person-group>. <article-title>&#x0201C;Accessibility came by accident&#x0201D;: use of voice-controlled intelligent personal assistants by people with disabilities</article-title>. In: <source>2018 CHI Conference on Human Factors in Computing Systems</source>. Montreal, QC (<year>2018</year>). <pub-id pub-id-type="doi">10.1145/3173574.3174033</pub-id></citation>
</ref>
<ref id="B22">
<label>22.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pradhan</surname> <given-names>A</given-names></name> <name><surname>Lazar</surname> <given-names>A</given-names></name> <name><surname>Findlater</surname> <given-names>L</given-names></name></person-group>. <article-title>Use of intelligent voice assistants by older adults with low technology use</article-title>. <source>ACM Trans Comput Hum Interact.</source> (<year>2020</year>) <volume>27</volume>:<fpage>1</fpage>&#x02013;<lpage>27</lpage>. <pub-id pub-id-type="doi">10.1145/3373759</pub-id></citation>
</ref>
<ref id="B23">
<label>23.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Purington</surname> <given-names>A</given-names></name> <name><surname>Taft</surname> <given-names>JG</given-names></name> <name><surname>Sannon</surname> <given-names>S</given-names></name> <name><surname>Bazarova</surname> <given-names>NN</given-names></name> <name><surname>Taylor</surname> <given-names>SH</given-names></name></person-group>. <article-title>&#x0201C;Alexa is my new bff&#x0201D;: social roles, user satisfaction, and personification of the Amazon Echo</article-title>. In: <source>2018 CHI Conference on Human Factors in Computing Systems</source>. Denver, CO (<year>2017</year>). <pub-id pub-id-type="doi">10.1145/3027063.3053246</pub-id></citation>
</ref>
<ref id="B24">
<label>24.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Paay</surname> <given-names>J</given-names></name> <name><surname>Kjeldskov</surname> <given-names>J</given-names></name> <name><surname>Hansen</surname> <given-names>KM</given-names></name> <name><surname>J&#x000F8;rgensen</surname> <given-names>T</given-names></name> <name><surname>Overgaard</surname> <given-names>KL</given-names></name></person-group>. <article-title>Digital ethnography of home use of digital personal assistants</article-title>. <source>Behav Inf Technol</source>. (<year>2020</year>) <volume>2020</volume>, <fpage>1</fpage>&#x02013;<lpage>19</lpage>. <pub-id pub-id-type="doi">10.1080/0144929X.2020.1834620</pub-id></citation>
</ref>
<ref id="B25">
<label>25.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Rubin</surname> <given-names>V</given-names></name> <name><surname>Chen</surname> <given-names>Y</given-names></name> <name><surname>Thorimbert</surname> <given-names>LM</given-names></name></person-group>. <article-title>Artificially intelligent conversational agents in libraries</article-title>. <source>Library Hi Tech.</source> (<year>2010</year>) <volume>28</volume>:<fpage>496</fpage>&#x02013;<lpage>522</lpage>. <pub-id pub-id-type="doi">10.1108/07378831011096196</pub-id></citation>
</ref>
<ref id="B26">
<label>26.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>McLean</surname> <given-names>G</given-names></name> <name><surname>Osei-Frimpong</surname> <given-names>K</given-names></name></person-group>. <article-title>Hey Alexa&#x02026;examine the variables influencing the use of artificial intelligent in-home voice assistants</article-title>. <source>Compu Hum Behav.</source> (<year>2019</year>) <volume>99</volume>:<fpage>28</fpage>&#x02013;<lpage>37</lpage>. <pub-id pub-id-type="doi">10.1016/j.chb.2019.05.009</pub-id></citation>
</ref>
<ref id="B27">
<label>27.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Han</surname> <given-names>S</given-names></name> <name><surname>Yang</surname> <given-names>H</given-names></name></person-group>. <article-title>Understanding adoption of intelligent personal assistants: a parasocial relationship perspective</article-title>. <source>Ind Manag Data Syst.</source> (<year>2018</year>) <volume>118</volume>:<fpage>618</fpage>&#x02013;<lpage>36</lpage>. <pub-id pub-id-type="doi">10.1108/IMDS-05-2017-0214</pub-id></citation>
</ref>
<ref id="B28">
<label>28.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Noone</surname> <given-names>C</given-names></name> <name><surname>McSharry</surname> <given-names>J</given-names></name> <name><surname>Smalle</surname> <given-names>M</given-names></name> <name><surname>Burns</surname> <given-names>A</given-names></name> <name><surname>Dwan</surname> <given-names>K</given-names></name> <name><surname>Devane</surname> <given-names>D</given-names></name> <etal/></person-group>. <article-title>Video calls for reducing social isolation and loneliness in older people: a rapid review</article-title>. <source>Cochrane Database Syst Rev.</source> (<year>2020</year>) <volume>5</volume>:<fpage>CD013632</fpage>. <pub-id pub-id-type="doi">10.1002/14651858.CD013632</pub-id><pub-id pub-id-type="pmid">32441330</pub-id></citation></ref>
<ref id="B29">
<label>29.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Knowles</surname> <given-names>B</given-names></name> <name><surname>Hanson</surname> <given-names>VL</given-names></name></person-group>. <article-title>The wisdom of older technology (non)users</article-title>. <source>Commun ACM</source>. (<year>2018</year>) <volume>61</volume>:<fpage>72</fpage>&#x02013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1145/3179995</pub-id></citation>
</ref>
<ref id="B30">
<label>30.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kowalski</surname> <given-names>J</given-names></name> <name><surname>Jaskulska</surname> <given-names>A</given-names></name> <name><surname>Skorupska</surname> <given-names>K</given-names></name> <name><surname>Biele</surname> <given-names>KAC</given-names></name> <name><surname>Kopec</surname> <given-names>W</given-names></name> <name><surname>Marasek</surname> <given-names>K</given-names></name></person-group>. <article-title>Older adults and voice interaction: a pilot study with google home</article-title>. In: <source>CHI EA &#x00027;19: Extended Abstracts of the 2019 CHI Conference on Human Factors in Computing Systems</source>. Glasgow (<year>2019</year>). <pub-id pub-id-type="doi">10.1145/3290607.3312973</pub-id></citation>
</ref>
<ref id="B31">
<label>31.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kim</surname> <given-names>S</given-names></name></person-group>. <article-title>Exploring how older adults use a smart speaker-based voice assistant in their first interactions: qualitative study</article-title>. <source>JMIR mHealth uHealth.</source> (<year>2021</year>) <volume>9</volume>:<fpage>e20427</fpage>. <pub-id pub-id-type="doi">10.2196/20427</pub-id><pub-id pub-id-type="pmid">33439130</pub-id></citation></ref>
<ref id="B32">
<label>32.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ameen</surname> <given-names>N</given-names></name> <name><surname>Hosany</surname> <given-names>S</given-names></name> <name><surname>Tarhini</surname> <given-names>A</given-names></name></person-group>. <article-title>Consumer interaction with cutting-edge technologies: implications for future research</article-title>. <source>Comput Human Behav.</source> (<year>2021</year>) <volume>120</volume>:<fpage>106761</fpage>. <pub-id pub-id-type="doi">10.1061/j.chb.2021.106761</pub-id></citation>
</ref>
<ref id="B33">
<label>33.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ruggiano</surname> <given-names>N</given-names></name> <name><surname>Brown</surname> <given-names>EL</given-names></name> <name><surname>Roberts</surname> <given-names>L</given-names></name> <name><surname>Suarez</surname> <given-names>CVF</given-names></name> <name><surname>Luo</surname> <given-names>Y</given-names></name> <name><surname>Hao</surname> <given-names>Z</given-names></name> <etal/></person-group>. <article-title>Chatbots to support people with dementia and their caregivers: systematic review of functions and quality</article-title>. <source>JMIR.</source> (<year>2021</year>) <volume>23</volume>:<fpage>e25006</fpage>. <pub-id pub-id-type="doi">10.2196/25006</pub-id><pub-id pub-id-type="pmid">34081019</pub-id></citation></ref>
<ref id="B34">
<label>34.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Whelan</surname> <given-names>B-M</given-names></name> <name><surname>Angus</surname> <given-names>D</given-names></name> <name><surname>Wiles</surname> <given-names>J</given-names></name> <name><surname>Chenery</surname> <given-names>HJ</given-names></name> <name><surname>Conway</surname> <given-names>ER</given-names></name> <name><surname>Copland</surname> <given-names>DA</given-names></name> <etal/></person-group>. <article-title>Toward the development of SMART communication technology: automating the analysis of communicative trouble and repair in dementia</article-title>. <source>Innovation in Aging.</source> (<year>2018</year>) <volume>3</volume>:<fpage>igy034</fpage>. <pub-id pub-id-type="doi">10.1093/geroni/igy034</pub-id><pub-id pub-id-type="pmid">30539162</pub-id></citation></ref>
<ref id="B35">
<label>35.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zidaru</surname> <given-names>T</given-names></name> <name><surname>Morrow</surname> <given-names>EM</given-names></name> <name><surname>Stockley</surname> <given-names>R</given-names></name></person-group>. <article-title>Ensuring patient and public involvement in the transition to AI-assisted mental health care: a systematic scoping review and agenda for design justice</article-title>. <source>Health Expect.</source> (<year>2021</year>) <volume>24</volume>:<fpage>1072</fpage>&#x02013;<lpage>124</lpage>. <pub-id pub-id-type="doi">10.1111/hex.13299</pub-id><pub-id pub-id-type="pmid">34118185</pub-id></citation></ref>
<ref id="B36">
<label>36.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Koenecke</surname> <given-names>A</given-names></name> <name><surname>Nam</surname> <given-names>A</given-names></name> <name><surname>Lake</surname> <given-names>E</given-names></name> <name><surname>Nudell</surname> <given-names>J</given-names></name> <name><surname>Quartey</surname> <given-names>M</given-names></name> <name><surname>Mengesha</surname> <given-names>Z</given-names></name> <etal/></person-group>. <article-title>Racial disparities in automated speech recognition</article-title>. <source>Proc Natl Acad Sci USA.</source> (<year>2020</year>) <volume>117</volume>:<fpage>7684</fpage>&#x02013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.1915768117</pub-id><pub-id pub-id-type="pmid">32205437</pub-id></citation></ref>
<ref id="B37">
<label>37.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Smith</surname> <given-names>E</given-names></name> <name><surname>Sumner</surname> <given-names>P</given-names></name> <name><surname>Hedge</surname> <given-names>C</given-names></name> <name><surname>Powell</surname> <given-names>G</given-names></name></person-group>. <article-title>Smart speaker devices can improve speech intelligibility in adults with intellectual disability</article-title>. <source>Int J Lang Commun Disord.</source> (<year>2021</year>) <volume>56</volume>:<fpage>583</fpage>&#x02013;<lpage>93</lpage>. <pub-id pub-id-type="doi">10.1111/1460-6984.12615</pub-id><pub-id pub-id-type="pmid">33772998</pub-id></citation></ref>
<ref id="B38">
<label>38.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>O&#x00027;Suilleabhain</surname> <given-names>PS</given-names></name> <name><surname>Gallagher</surname> <given-names>S</given-names></name> <name><surname>Steptoe</surname> <given-names>A</given-names></name></person-group>. <article-title>Loneliness, living alone, and all-cause mortality: the role of emotional and social loneliness in the elderly during 19 years of follow-up</article-title>. <source>Psychosom Med.</source> (<year>2021</year>) <volume>81</volume>:<fpage>5212</fpage>&#x02013;<lpage>526</lpage>. <pub-id pub-id-type="doi">10.1097/PSY.0000000000000710</pub-id><pub-id pub-id-type="pmid">31094903</pub-id></citation></ref>
<ref id="B39">
<label>39.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ge</surname> <given-names>L</given-names></name> <name><surname>Yap</surname> <given-names>CW</given-names></name> <name><surname>Ong</surname> <given-names>R</given-names></name> <name><surname>Heng</surname> <given-names>BH</given-names></name></person-group>. <article-title>Social isolation, loneliness and their relationships with depressive symptoms: a population-based study</article-title>. <source>PLoS ONE.</source> (<year>2017</year>) <volume>12</volume>:<fpage>e0182145</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0182145</pub-id><pub-id pub-id-type="pmid">28832594</pub-id></citation></ref>
<ref id="B40">
<label>40.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname> <given-names>R</given-names></name> <name><surname>Wang</surname> <given-names>H</given-names></name> <name><surname>Edelman</surname> <given-names>LS</given-names></name> <name><surname>Tracy</surname> <given-names>EL</given-names></name> <name><surname>Demiris</surname> <given-names>G</given-names></name> <name><surname>Sard</surname> <given-names>KA</given-names></name> <etal/></person-group>. <article-title>Loneliness as a mediator of the impact of social isolation on cognitive functioning of Chinese older adults</article-title>. <source>Age Ageing.</source> (<year>2020</year>) <volume>49</volume>:<fpage>599</fpage>&#x02013;<lpage>604</lpage>. <pub-id pub-id-type="doi">10.1093/ageing/afaa020</pub-id><pub-id pub-id-type="pmid">32147683</pub-id></citation></ref>
<ref id="B41">
<label>41.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Davies</surname> <given-names>AR</given-names></name> <name><surname>Honeyman</surname> <given-names>M</given-names></name> <name><surname>Gann</surname> <given-names>B</given-names></name></person-group>. <article-title>Addressing the digital inverse care law in the time of COVID-19: potential for digital technology to exacerbate or mitigate health inequalities</article-title>. <source>J Med Internet Res.</source> (<year>2021</year>) <volume>23</volume>:<fpage>e21726</fpage>. <pub-id pub-id-type="doi">10.2196/21726</pub-id><pub-id pub-id-type="pmid">33735096</pub-id></citation></ref>
<ref id="B42">
<label>42.</label>
<citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tappen</surname> <given-names>RM</given-names></name> <name><surname>Cooley</surname> <given-names>ME</given-names></name> <name><surname>Luckmann</surname> <given-names>R.</given-names></name> <name><surname>Panday</surname> <given-names>S</given-names></name></person-group>. <article-title>Digital health information disparities in older adults: a mixed methods study</article-title>. <source>J Racial Ethn Health Disparities</source>. (<year>2021</year>) <volume>2021</volume>:<fpage>1</fpage>&#x02013;<lpage>11</lpage>. <pub-id pub-id-type="doi">10.1007/s40615-020-00931-3</pub-id><pub-id pub-id-type="pmid">33415705</pub-id></citation></ref>
</ref-list> 
</back>
</article>