AUTHOR=Lei Lei , Xue Xiaojing , Feng Gang , Wang Xiaoyan , Jiang Yuan 

TITLE=Medical ozone treatment for pain, fatigue, anxiety, and depression in cancer patients: a scoping review

JOURNAL=Frontiers in Psychology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2025.1687754

DOI=10.3389/fpsyg.2025.1687754

ISSN=1664-1078

ABSTRACT=AimThe aim of this study is to conduct a scoping review on the application of medical ozone treatment in managing symptoms (including Pain, Fatigue, Anxiety, and Depression) among cancer patients, aiming to provide clinical medical staff with a reference for implementing a novel approach to symptom management.MethodsThis scoping review was conducted based on the methodology presented by Arksey and O’Malley and The Joanna Briggs Institute methodology was employed to conduct scoped reviews of Pubmed, Web of science, CINAHL, EMBASE, MEDLINE, APA and CNKI in order to address the research question: “What is the impact of medical ozone treatment on pain, fatigue, anxiety, and depression in cancer patients?" Two independent reviewers select samples by screening and reviewing articles and extract data using a data chart form. The protocol was registered in the Open Science Framework (OSF.)ResultsA total of 16 articles were included to analyze and integrate the use of medical ozone, medical ozone dose, symptom assessment tools, and symptom management.ConclusionThe effectiveness of medical ozone treatment in managing key symptoms (including Pain, Fatigue, Anxiety, and Depression) among cancer patients has been preliminarily verified. Future studies need to cover a wider range of areas and larger sample sizes, as well as conduct long-term follow-up studies and multi-dimensional evaluation to enhance the universality and reliability of the results.