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<journal-id journal-id-type="publisher-id">Front. Psychol.</journal-id>
<journal-title-group>
<journal-title>Frontiers in Psychology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychol.</abbrev-journal-title>
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<issn pub-type="epub">1664-1078</issn>
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<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyg.2025.1645442</article-id><article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading"><subject>Systematic Review</subject></subj-group>
</article-categories>
<title-group>
<article-title>Delay discounting and anxiety: a systematic review on current evidence for clinical and non-clinical population</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Dom&#x00ED;nguez Rojas</surname> <given-names>Miguel</given-names></name><xref ref-type="aff" rid="aff1"/><xref ref-type="author-notes" rid="fn0003"><sup>&#x2020;</sup></xref>
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<contrib contrib-type="author" corresp="yes"><name><surname>Velo Higueras</surname> <given-names>Carlos</given-names></name><xref ref-type="aff" rid="aff1"/><xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref><xref ref-type="author-notes" rid="fn0003"><sup>&#x2020;</sup></xref>
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<aff id="aff1"><institution>Universidad Europea de Valencia, Faculty of Health Sciences</institution>, <city>Valencia</city>, <country country="es">Spain</country></aff>
<author-notes><corresp id="c001"><label>&#x002A;</label>Correspondence: Carlos Velo Higueras, <email xlink:href="mailto:carlos.velo@universidadeuropea.es">carlos.velo@universidadeuropea.es</email></corresp><fn fn-type="other" id="fn0003"><label>&#x2020;</label><p>ORCID: Miguel Dom&#x00ED;nguez Rojas, <uri xlink:href="https://orcid.org/0009-0003-1399-5019">orcid.org/0009-0003-1399-5019</uri>; Carlos Velo Higueras, <uri xlink:href="https://orcid.org/0000-0001-8826-7743">orcid.org/0000-0001-8826-7743</uri></p></fn></author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2025-10-19">
<day>19</day>
<month>10</month>
<year>2025</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2025</year>
</pub-date>
<volume>16</volume>
<elocation-id>1645442</elocation-id>
<history>
<date date-type="received">
<day>11</day>
<month>06</month>
<year>2025</year>
</date>
<date date-type="accepted">
<day>06</day>
<month>10</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2025 Dom&#x00ED;nguez Rojas and Velo Higueras.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Dom&#x00ED;nguez Rojas and Velo Higueras</copyright-holder>
<license><ali:license_ref start_date="2025-10-19">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Introduction</title>
<p>Delay discounting (DD) is a psychological process that involves the tendency to prefer immediate rewards over delayed rewards, even if the latter are greater. The study of this process has been approached from different conceptualisations, including delay discounting, intertemporal choice and temporal discounting. The study of this construct began in the field of economics, but has subsequently been applied to various fields of psychology. There seems to be a generalised tendency among people with various pathologies to prefer immediate and smaller rewards to larger but delayed ones, although this tendency is not clear in the case of people with anxiety.</p>
</sec>
<sec id="sec2">
<title>Method</title>
<p>To study the relationship between anxiety and DD, a systematic review was carried out in accordance with the PRISMA 2020 guidelines, including 25 studies with a total sample of 12,728 subjects from the clinical and general population.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>The results point to a positive relationship between anxiety and DD as found in most studies in both clinical and general populations. Other studies have provided some interesting nuances on this relationship. Only two studies have found a negative relationship between DD and anxiety.</p>
</sec>
<sec id="sec4">
<title>Discussion and conclusion</title>
<p>The analysis of our review suggests a positive relationship between DD and anxiety in the general population, although this conclusion is limited by the heterogeneity of results and still cannot be generalised to other populations due to the low representativeness of the clinical population in this review.</p>
</sec>
</abstract>
<kwd-group>
<kwd>delay of gratification</kwd>
<kwd>anxiety</kwd>
<kwd>delay discounting</kwd>
<kwd>temporal discounting</kwd>
<kwd>systematic review</kwd>
</kwd-group><funding-group><funding-statement>The author(s) declare that financial support was received for the research and/or publication of this article. Processing and publication charges were founded by Universidad Europea de Madrid.</funding-statement></funding-group>
<counts>
<fig-count count="1"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="81"/>
<page-count count="12"/>
<word-count count="10346"/>
</counts>
<custom-meta-group>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Psychopathology</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<label>1</label>
<title>Introduction</title>
<p>The study of Delay of Gratification (DG) initially emerged within the field of economics (<xref ref-type="bibr" rid="ref38">Kirby, 1997</xref>). A recent definition formulates it as a psychological construct that involves the choice of larger rewards in the future over smaller and immediate rewards (<xref ref-type="bibr" rid="ref14">Buczny, 2020</xref>). This ability of individuals has also been addressed by the constructs of Delay Discounting (DD; <xref ref-type="bibr" rid="ref54">Madden et al., 2011</xref>) and Temporal Discounting (TD; <xref ref-type="bibr" rid="ref70">Ruggeri et al., 2022</xref>) which, in opposite way, focus on the subjective devaluation of the first reinforcement when delayed over time. Higher levels of DD or TD result in a greater inclination to select immediate rewards over those that are delayed, even when the latter are of a higher value.</p>
<p>Thereby, under these considerations, expressions of DG imply a greater predilection for the delayed stimulus, the one with the greatest load of reward. This definition draws a clear continuum among DG and DD, showing two poles of the same decision making and behavioural guide.</p>
<p>Reviewing common methods of study in this topic, these discounting constructs have been studied using standardised tests like, for instance, the Monetary Choice Questionnaire (MCQ; <xref ref-type="bibr" rid="ref41">Kirby et al., 1999</xref>) or 5-trial adjusting delay discounting task (5-ADT; <xref ref-type="bibr" rid="ref42">Koffarnus and Bickel, 2014</xref>) where subjects are offered the possibility of repeatedly choosing between a smaller and closer reward or a larger and more delayed one. These tests lead to a calculation of the DD by the discount rate (k), indicating the preference for immediate rewards over delayed rewards. The higher the k, the greater the preference.</p>
<p>Thereby, the construct DD is regarded as a parameter related to impulsivity (<xref ref-type="bibr" rid="ref48">Levitt et al., 2020</xref>; <xref ref-type="bibr" rid="ref77">Tschernegg et al., 2015</xref>). This impulsivity has previously been proposed as a key feature in a range of psychiatric disorders, extending beyond those traditionally associated with high impulsivity, such as attention deficit hyperactivity disorder, disruptive disorder, impulse control and behavioural disorders, or addictive disorders (<xref ref-type="bibr" rid="ref20">Crisp and Grant, 2024</xref>). Furthermore, it is associated with other disorders, including borderline personality disorder, mood disorders, and panic disorder with agoraphobia (<xref ref-type="bibr" rid="ref20">Crisp and Grant, 2024</xref>; <xref ref-type="bibr" rid="ref44">Kulacaoglu and Kose, 2018</xref>). For this reason, DD has been put forth as a transdiagnostic process for certain psychiatric disorders (<xref ref-type="bibr" rid="ref2">Amlung et al., 2019</xref>).</p>
<p>The physiological mechanisms underlying discounting for delay are not yet fully elucidated. Nevertheless, a significant relationship has been identified between specific activation patterns in particular regions of the brain (<xref ref-type="bibr" rid="ref78">Ust&#x00E1;rroz and Grandi, 2016</xref>), as well as a correlation between delay discounting and grey matter volume in the orbitofrontal cortex and anterior cingulate cortex, two regions of the brain associated with behavioural self-regulation and decision-making (<xref ref-type="bibr" rid="ref49">Li et al., 2019</xref>) It has been also described the predictability of the delay discounting behaviour in older adolescents regarding the functional dynamic connection of the amygdala, suggesting a likely involvement of mesolimbic and mesocortical dopamine pathways in adolescents with these circuits already developed (<xref ref-type="bibr" rid="ref56">Mertens et al., 2025</xref>).</p>
<p>Nevertheless, although the concept and operation seem clear, and the definition sound, some authors have recently pointed out inconsistencies in DD research paradigm (<xref ref-type="bibr" rid="ref8">Bailey et al., 2021</xref>). Under that discussion, the first challenge concerns the high conceptual heterogeneity found in the literature. This heterogeneity could underscore relevant nuances of the process across samples and situations, and would benefit from a disambiguation of the field.</p>
<p>On the same line, the systematic review and meta-analysis from <xref ref-type="bibr" rid="ref79">Weinsztok et al. (2021)</xref> highlights the considerable heterogeneity and also discrepancy in results, thereby indicating a substantial impact of publication bias in studies employing smaller samples.</p>
<p>Moreover, <xref ref-type="bibr" rid="ref83">Yeh et al. (2021)</xref> conducted a study that examined the association between impulsivity, other personality traits and intelligence while controlling for socioeconomic factors, and the findings indicated the likely presence of bidirectional relationship between these socio-economic factors and the capacity to delay gratification. An indirect relation not commonly addressed that warrants further investigation the extend the construct.</p>
<p>Apart from this clarification, and regarding the application to the field of health, DD has been the subject of extensive study in the context of addiction. Individuals with Alcohol use disorder (AUD; <xref ref-type="bibr" rid="ref1">American Psychiatric Association, 2022</xref>) have been found to show a higher discount rate (k), then a more intense preference for closer reward than healthy controls (<xref ref-type="bibr" rid="ref25">Gowin et al., 2019</xref>). Also, in individuals who consume both cannabis and alcohol, particularly those with more severe alcohol abuse, exhibit a greater degree of DD than those who solely use alcohol or those with less severe alcohol addiction (<xref ref-type="bibr" rid="ref53">MacKillop et al., 2010</xref>; <xref ref-type="bibr" rid="ref66">Phung et al., 2019</xref>). Among users of other substances such as tobacco, heroin or cocaine, they have also been reported with higher scores on discount rates compared to healthy controls (<xref ref-type="bibr" rid="ref40">Kirby and Petry, 2004</xref>; <xref ref-type="bibr" rid="ref43">Konecky and Lawyer, 2015</xref>). Even in the fuzzy boundary of addictive substances, it has been found significant relationships between high rates of DD and e-cigarette use, concurrently in size effect to those relations reported in tobacco users (<xref ref-type="bibr" rid="ref12">Bia&#x0142;aszek et al., 2017</xref>). This find suggests a pattern of higher discounting rates across a wide variety of potentially addictive disorders, even including the so-called non-substance addictions (<xref ref-type="bibr" rid="ref4">Amlung et al., 2017</xref>). Nevertheless, recalling the hitherto explained discrepancies, a recent meta-analytic review on addiction indicated the persistence of substantial heterogeneity in findings, hindering robust conclusions (<xref ref-type="bibr" rid="ref79">Weinsztok et al., 2021</xref>).</p>
<p>In a broader scope, the DD construct has been the subject of study also in other areas of clinical psychology research. For instance, <xref ref-type="bibr" rid="ref67">Pinto et al. (2014)</xref> investigated the mechanism of DD in individuals with obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD). Their findings revealed lower scores on DD tasks in individuals with OCPD, irrespective of whether they also had OCD, when compared to healthy controls and individuals with OCD alone. The authors suggest that these findings are consistent with the characterisation of perfectionism and rigidity in OCD and contribute, on their opinion, to a deeper understanding of this concept in the context of specific disorders.</p>
<p>In their meta-analysis, <xref ref-type="bibr" rid="ref2">Amlung et al. (2019)</xref> reported results were levels of DD compared to healthy controls were systematically higher in all disorders included, excepting for anorexia nervosa and obsessive-compulsive disorder. This is consistent with the psychological inflexibility and excessive control characteristic of these individuals.</p>
<p>Aiming at these eating disorders, the study carried out by <xref ref-type="bibr" rid="ref75">Steward et al. (2017)</xref> points out the DD as a potentially fruitful avenue of investigation for enhancing our understanding of eating disorders. The capacity to defer gratification has been examined in patients with anorexia nervosa, both the restrictive and the purging subtypes, as well as those with binge eating disorder, in comparison with healthy controls. As anticipated, the DD tasks revealed higher scores in subjects with binge eating disorder and purge-type anorexia nervosa compared to those with restrictive-type anorexia nervosa (<xref ref-type="bibr" rid="ref75">Steward et al., 2017</xref>). Additionally, a meta-analysis by <xref ref-type="bibr" rid="ref3">Amlung et al. (2016)</xref> exposed how individuals with low self-control towards eating stimuli and obesity consistently exhibited a diminished capacity to delay gratification.</p>
<p>Also, in the treatment and monitoring of certain chronic diseases, the capacity to hold up rewards for better achievements has been described as of paramount importance (<xref ref-type="bibr" rid="ref18">Conthe et al., 2014</xref>). As some reports indicates, a higher k rate is associated with lower engagement in monitoring health behaviours in patients with diabetes (<xref ref-type="bibr" rid="ref16">Campbell et al., 2021</xref>; <xref ref-type="bibr" rid="ref22">Epstein et al., 2021</xref>). Furthermore, DD is associated with poor prognosis for psychosocial adjustment, and also with the development of anxiety and depressive symptoms (<xref ref-type="bibr" rid="ref5">Anderson and Stanger, 2023</xref>; <xref ref-type="bibr" rid="ref15">Campbell and Egede, 2023</xref>). Conversely, the resistance to palliative care and accepting support services that could greatly improve the well-being of patients with conditions like prostate cancer is puzzling. This reveals an important insight: patients often choose to avoid the immediate effort or discomfort of health-promoting actions, even if it could lead to better well-being in the long run (<xref ref-type="bibr" rid="ref24">Gerhart et al., 2016</xref>).</p>
<p>The impact of anxiety on public health in recent years appears to be a significant and growing concern (<xref ref-type="bibr" rid="ref65">Penninx et al., 2021</xref>; <xref ref-type="bibr" rid="ref45">Latas et al., 2019</xref>), but the current evidence base on the relationship between DD and anxiety is still relatively limited. One illustrating example of this relation is the randomised experimental study conducted by <xref ref-type="bibr" rid="ref69">Rounds et al. (2007)</xref> subjects with high levels of social anxiety demonstrated significantly greater discounting than subjects with low levels of social anxiety in the non-threat condition. This finding suggests a notable difference in the perceived value of rewards under normal conditions between the two groups. <xref ref-type="bibr" rid="ref81">Xia et al. (2017)</xref> assessed the impulsivity of subjects with high trait anxiety in comparison to subjects with low trait anxiety through a delay discounting task. The authors postulated intolerance to uncertainty as a potential explanation for the observed results. Other authors have proposed that delay discounting may act as a mediator between psychological inflexibility and various mental health issues, including depression, anxiety, eating disorders and hostility (<xref ref-type="bibr" rid="ref46">Levin et al., 2018</xref>).</p>
<p>Again, there are other construct validity issues that may be contributing to the emergence of contradictory results across studies. In recent research, <xref ref-type="bibr" rid="ref6">Armstrong and Hoge (2024)</xref> studied the relationship between DD and the experience of anxiety in patients diagnosed with anxiety disorders, and their results were not significant, contrasting with the previous publications showing a notable correlation between anxiety and impulsivity across diverse populations (<xref ref-type="bibr" rid="ref17">Cheng et al., 2022</xref>; <xref ref-type="bibr" rid="ref28">Guo et al., 2024</xref>; <xref ref-type="bibr" rid="ref44">Kulacaoglu and Kose, 2018</xref>; <xref ref-type="bibr" rid="ref59">Moustafa et al., 2017</xref>).</p>
<p>Thereby, the considerable variability in the conceptual approach to the DD paradigm, in conjunction with the absence of a robust theoretical model, has the potential to hinder the interpretation of results. The incorporation of studies examining diverse approaches could facilitate the elucidation of the specific relationship between DD and anxiety.</p>
<p>In conclusion, although a wide body of research has been published suggesting a relationship between various psychological disorders and delay discounting (DD), and some authors have tried to correlate DD with personality or intelligence factors, the relationship between DD and anxiety itself remains unclear. This systematic review aims to gather a wide scope set of studies related to DD and anxiety in order to analyse the recent research, conducted over the past 10&#x202F;years, in both clinical and general populations. This review shall help to assess the current conceptual knowledge and, thereby, to clarify the cross-sectional elements of the construct as well as pointing out the main discrepancies still to solve.</p>
</sec>
<sec sec-type="methods" id="sec6">
<label>2</label>
<title>Methods</title>
<p>A systematic review was conducted in accordance with the PRISMA 2020 guideline (<xref ref-type="bibr" rid="ref63">Page et al., 2021</xref>).</p>
<sec id="sec7">
<label>2.1</label>
<title>Search strategy and sources</title>
<p>A systematic search was conducted in PubMed, Web of Science (WoS) and Scopus databases. The search was limited to scientific articles published in peer-reviewed journals, written in English and Spanish. To identify all relevant articles published between 2013 and 2023 the search was conducted using the term related to DG (using the operator &#x201C;or&#x201D;) and the addition to the term &#x201C;anxiety&#x201D; with the operator &#x201C;and,&#x201D; in title, abstract or key words. The variety of terminology employed throughout the literature was chosen with the objective of ensuring inclusion of all potentially pertinent studies in the review. The terms referring DG were (&#x2018;discounting&#x2019;, &#x2018;reward delay&#x2019;, &#x2018;delay of gratification&#x2019;, &#x2018;delayed reinforcement&#x2019;, &#x2018;intertemporal choice&#x2019; and &#x2018;intertemporal decision&#x2019;).</p>
</sec>
<sec id="sec8">
<label>2.2</label>
<title>Eligibility criteria</title>
<p>The following criteria was set: Only empirical papers published in peer-reviewed journals and focused on human samples were included. They must show a clear description of definitions and assessments of the constructs of interest, hitherto explained, anxiety and delay of gratification or any of their names, provided a proper definition.</p>
<p>As inclusion criteria, Delay of Gratification was defined as any test in which subjects were presented with the option of receiving a smaller, immediate reward or a larger but delayed reward instead. Additionally, Anxiety measurement was included only if a standardised psychometric test was applied, or a direct expression of the subject was recorded.</p>
<p>Apart from not meeting the inclusion criteria, exclusion criteria included non-pair-review-type papers, defining concepts in terms not related to behavioural research, not including clear definition of constructs of interest, or not explicitly addressing the relation between Gratification Delay and Anxiety.</p>
</sec>
<sec id="sec9">
<label>2.3</label>
<title>Selection process</title>
<p>The selection of documents for review was conducted by a single reviewer basing on search strategy (<xref ref-type="fig" rid="fig1">Figure 1</xref>). The overall review process was supervised by two independent reviewers.</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>Summary of the PRISMA flow diagram.</p>
</caption>
<graphic xlink:href="fpsyg-16-1645442-g001.tif" mimetype="image" mime-subtype="tiff">
<alt-text content-type="machine-generated">Flowchart depicting the identification of new studies via databases and registers. Starts with 420 records identified, from which 157 duplicates are removed. Of the 263 records screened, 177 are excluded. 86 reports are sought for retrieval, 3 are not retrieved. 83 reports are assessed for eligibility; 58 are excluded. A total of 25 studies are included in the review.</alt-text>
</graphic>
</fig>
<p>The following terms were considered: &#x2018;delay discounting&#x2019; and &#x2018;temporal discounting&#x2019;, which refer to the devaluation of reinforcement as it is delayed (<xref ref-type="bibr" rid="ref2">Amlung et al., 2019</xref>); &#x2018;intertemporal choice/decision&#x2019; (<xref ref-type="bibr" rid="ref36">Kalenscher and Pennartz, 2008</xref>; <xref ref-type="bibr" rid="ref55">Marchetti et al., 2014</xref>) which, in a more general sense, examines the discrepancy in the perceived value of reinforcement contingent on its temporal positioning; and &#x2018;Delay of Gratification&#x2019; or &#x2018;Reward Delay&#x2019;, which underscores an individual&#x2019;s capacity to defer gratification (<xref ref-type="bibr" rid="ref23">Fern&#x00E1;ndez Garc&#x00ED;a et al., 2021</xref>).</p>
<p>The final search was conducted on 14 January 2024. A total of 205 results were retrieved from the WoS database, 163 from Scopus, and 52 from PubMed. A total of 157 papers were identified as duplicates and subsequently excluded. The remaining 263 abstracts and methods were then reviewed to ascertain whether they met the inclusion criteria. A total of 177 papers were excluded from further analysis, as they did not meet the pre-established criteria. Among excluded reports, 88 were deemed irrelevant to the topic, primarily due to the non-behavioural application of the term &#x2018;discounting&#x2019;, 46 studies were found to have employed an invalid measure for anxiety, as defined by established criteria, 23 studies did not studied human subjects, 14 were excluded as they differed in design from those for which this review was conducted, four were not scientific articles, and two studies did not assess delay of gratification. The remaining 86 papers were then subjected to a further assessment to determine their eligibility. A further examination of the reports led to the exclusion of 54 papers on the grounds that they did not explicitly assess the relationship between delayed gratification and anxiety, and a further four on the basis that they addressed concepts that were incompatible with the objective of this review. Three articles were excluded from this review due to unavailability of the necessary resources. The remaining 25 articles were subjected to a process of data extraction, the results of which are presented in <xref ref-type="table" rid="tab1">Table 1</xref>.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Summary of studies included in the review.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Authors</th>
<th align="center" valign="top" colspan="5">Sample</th>
<th align="left" valign="top" rowspan="2">Design</th>
<th align="left" valign="top" rowspan="2">Anxiety assessment</th>
<th align="left" valign="top" rowspan="2">DD assessment&#x002A;&#x002A;</th>
<th align="left" valign="top" rowspan="2">Main results</th>
</tr>
<tr>
<th align="center" valign="top">N</th>
<th align="center" valign="top">Age (X&#x0305; &#x00B1; SD)</th>
<th align="left" valign="top">Detail&#x002A;</th>
<th align="center" valign="top">Biol. gender (% Female)</th>
<th align="left" valign="top">Diagnosis</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref50">Li et al. (2023)</xref>
</td>
<td align="center" valign="top">1,417</td>
<td align="center" valign="top">13.83; 1.48</td>
<td align="left" valign="top">China</td>
<td align="center" valign="top">48.3%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">observational, Cross-sectional</td>
<td align="left" valign="top">CASI</td>
<td align="left" valign="top">MCQ</td>
<td align="left" valign="top">Negative correlation between ICR of MCQ and CASI (not significant)</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref46">Levin et al. (2018)</xref>
</td>
<td align="center" valign="top">389</td>
<td align="center" valign="top">20.1; 3.5</td>
<td align="left" valign="top">Caucasian</td>
<td align="center" valign="top">69.7%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">observational, Cross-sectional</td>
<td align="left" valign="top">CCAPS-34</td>
<td align="left" valign="top">ADT-5</td>
<td align="left" valign="top">General anxiety and ADT <italic>r</italic>&#x202F;=&#x202F;&#x2212;0.11</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref84">Zampella and Benau (2022)</xref>
</td>
<td align="center" valign="top">152</td>
<td align="center" valign="top">35.5;11.6</td>
<td align="left" valign="top">USA</td>
<td align="center" valign="top">45.0%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">DAS-E</td>
<td align="left" valign="top">DGI-35</td>
<td align="left" valign="top"><italic>r</italic>&#x202F;=&#x202F;&#x2212;0.50 DAS-E and DGI</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref61">Nigro et al. (2017)</xref>
</td>
<td align="center" valign="top">1,010</td>
<td align="center" valign="top">15.37; 2.05</td>
<td align="left" valign="top">Italian</td>
<td align="center" valign="top">52.5%</td>
<td align="left" valign="top">Gambling</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">DASS-21</td>
<td align="left" valign="top">MCQ</td>
<td align="left" valign="top"><italic>r</italic>&#x202F;=&#x202F;0.077 MCQ and DASS</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref34">Jiao et al. (2022)</xref>
</td>
<td align="center" valign="top">609</td>
<td align="center" valign="top">Young adults</td>
<td align="left" valign="top">Chinese</td>
<td align="center" valign="top">59.8%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">GAD-7; PHQ-9</td>
<td align="left" valign="top">ADOG</td>
<td align="left" valign="top"><italic>r</italic> =&#x202F;&#x2212;0.209 GAD and ADOG; &#x2212;0.186 PHQ and ADOG</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref85">Zhang et al. (2020)</xref>
</td>
<td align="center" valign="top">105</td>
<td align="center" valign="top">20.45; 1.87</td>
<td align="left" valign="top">Chinese</td>
<td align="center" valign="top">54.3%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">STAI</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top"><italic>r</italic>&#x202F;=&#x202F;0.34 STAI and discount rate</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref29">Haines et al. (2020)</xref>
</td>
<td align="center" valign="top">132; 800; 35</td>
<td align="center" valign="top">20.1; 4.6 and 35.1; 10.8 and 35.8; 10.3</td>
<td align="left" valign="top">USA</td>
<td align="center" valign="top">53.6%</td>
<td align="left" valign="top">Substance abuse</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">STAI</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top"><italic>&#x03B2;</italic>&#x202F;=&#x202F;[&#x2212;0.045, &#x2212;0.011] STAI-S and reward valuation</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref15">Campbell and Egede (2023)</xref>
</td>
<td align="center" valign="top">365</td>
<td align="center" valign="top">61.8</td>
<td align="left" valign="top">USA</td>
<td align="center" valign="top">29.8%</td>
<td align="left" valign="top">Type 2 diabetes</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">GAD-8</td>
<td align="left" valign="top">QDQ</td>
<td align="left" valign="top">beta&#x202F;=&#x202F;0.52; delay aversion and anxiety; DD and anxiety beta&#x202F;=&#x202F;0.46</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref74">Steinglass et al. (2017)</xref>
</td>
<td align="center" valign="top">119</td>
<td align="center" valign="top">30;4 and 29;7.6</td>
<td align="left" valign="top">USA</td>
<td align="center" valign="top">43% and 48%</td>
<td align="left" valign="top">SAD; AN; OCD</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">STAI</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top">Discount and STAI-T <italic>r</italic>&#x202F;=&#x202F;&#x2212;0.210. SAD and discount t (188)&#x202F;=&#x202F;1.82; <italic>p</italic>&#x202F;=&#x202F;0.071</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref64">Patt et al. (2021)</xref>
</td>
<td align="center" valign="top">44</td>
<td align="center" valign="top">19; 1.2</td>
<td/>
<td align="center" valign="top">100.0%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">STAI</td>
<td align="left" valign="top">Ad Hoc scale</td>
<td align="left" valign="top">STAI-S and AUC experiential <italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.33, <italic>p</italic>&#x202F;=&#x202F;0.049. STAI-T and AUC experiential <italic>&#x03B2;</italic>&#x202F;=&#x202F;0.48, <italic>p</italic>&#x202F;=&#x202F;0.003</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref21">DeRosa et al. (2023)</xref>
</td>
<td align="center" valign="top">1843</td>
<td align="center" valign="top">10.6; 3.17</td>
<td align="left" valign="top">Varied</td>
<td align="center" valign="top">33.8%</td>
<td align="left" valign="top">9 different</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">K-SADS</td>
<td align="left" valign="top">ADT-5</td>
<td align="left" valign="top">Positive correlation between anxiety and discount rate in food reward measure.</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref24">Gerhart et al. (2016)</xref>
</td>
<td align="center" valign="top">212</td>
<td align="center" valign="top">62; 8</td>
<td align="left" valign="top">Caucasian</td>
<td align="center" valign="top">0.0%</td>
<td align="left" valign="top">Prostate Cancer</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">DASS-21</td>
<td align="left" valign="top">DGI-10</td>
<td align="left" valign="top"><italic>r</italic>&#x202F;=&#x202F;&#x2212;0.23 Anxiety and DG</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref82">Xia et al. (2023)</xref>
</td>
<td align="center" valign="top">1,016</td>
<td align="center" valign="top">[17&#x2013;26]</td>
<td align="left" valign="top">Chinese</td>
<td align="center" valign="top">60.9%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">GAD-7, PHQ-9</td>
<td align="left" valign="top">ADOG</td>
<td align="left" valign="top"><italic>p</italic>&#x202F;=&#x202F;&#x2212;0.238 GAD-7 and ADOG; <italic>p</italic>&#x202F;=&#x202F;&#x2212;0.189 PHQ-9 and ADOG</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref57">Minhas et al. (2020)</xref>
</td>
<td align="center" valign="top">730; 602</td>
<td align="center" valign="top">21.44;1.19<break/>22.63;1.03</td>
<td align="left" valign="top">Canada<break/>USA</td>
<td align="center" valign="top">52.6%<break/>57.3%</td>
<td align="left" valign="top">HED</td>
<td align="left" valign="top">Observational, Cross-sectional</td>
<td align="left" valign="top">GAD-7, PHQ-9</td>
<td align="left" valign="top">ADT-5</td>
<td align="left" valign="top">Higher discount rate in high and moderate psychiatric severity groups.</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref47">Levitt et al. (2023)</xref>
</td>
<td align="center" valign="top">1,388</td>
<td align="center" valign="top">38.99; 13.70</td>
<td align="left" valign="top">Canada &#x002A;</td>
<td align="center" valign="top">57.9%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observacional, Cross-sectional</td>
<td align="left" valign="top">PHQ; PHQ-Anx</td>
<td align="left" valign="top">MCQ</td>
<td align="left" valign="top"><italic>r</italic>&#x202F;=&#x202F;0.15 high discount rate and PHQ; <italic>r</italic>&#x202F;=&#x202F;0.1 high discount rate and PHQ-anx</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref58">Morasco et al. (2019)</xref>
</td>
<td align="center" valign="top">75</td>
<td/>
<td/>
<td/>
<td align="left" valign="top">Chronic pain</td>
<td align="left" valign="top">Observacional, Cross-sectional</td>
<td/>
<td/>
<td align="left" valign="top">Positive correlation between discount rate and anxiety.</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref68">Robertson et al. (2023)</xref>
</td>
<td align="center" valign="top">202</td>
<td align="center" valign="top">Adults</td>
<td align="left" valign="top">UK</td>
<td align="center" valign="top">50.9%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observacional, Cross-sectional</td>
<td align="left" valign="top">DASS-21</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top">Not significant between discount rate and anxiety &#x1D436;&#x1D43C;90%&#x202F;=&#x202F;[&#x2212;0.01, 0.1]</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref30">Ho et al. (2023)</xref>
</td>
<td align="center" valign="top">414</td>
<td align="center" valign="top">15.6; 0.6</td>
<td align="left" valign="top">Vietnamese</td>
<td align="center" valign="top">49.0%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Observacional, Longitudinal</td>
<td align="left" valign="top">DASS-21</td>
<td align="left" valign="top">ADT-5</td>
<td align="left" valign="top">Discount at T1 predicted anxiety at T2 <italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.10,</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref80">Worthy et al. (2014)</xref>
</td>
<td align="center" valign="top">56</td>
<td align="center" valign="top">Young adults</td>
<td align="left" valign="top">USA</td>
<td/>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Experimental, Cross-sectional</td>
<td align="left" valign="top">BAI</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top">Anxiety and proportion of times participants selected the increasing option throughout the task <italic>r</italic>&#x202F;=&#x202F;&#x2212; 0.12 not significant</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref81">Xia et al. (2017)</xref>
</td>
<td align="center" valign="top">52</td>
<td align="center" valign="top">19.4 and 19.7</td>
<td align="left" valign="top">Chinese</td>
<td align="center" valign="top">50.0%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Experimental, Cross-sectional</td>
<td align="left" valign="top">STAI-T</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top">ANOVA [<italic>F</italic> (1, 50)&#x202F;=&#x202F;4.75, <italic>p</italic>&#x202F;=&#x202F;0.034, &#x03B7;<sup>2</sup>p&#x202F;=&#x202F;0.087] Impulsivity within-subject factor and anxiety between subject factor.</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref76">Tanovic et al. (2018)</xref>
</td>
<td align="center" valign="top">54</td>
<td align="center" valign="top">21.2;2.59</td>
<td align="left" valign="top">Caucasian 57.40%</td>
<td align="center" valign="top">72.2%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Experimental, Cross-sectional</td>
<td align="left" valign="top">Likert 7</td>
<td align="left" valign="top">TCIP and MCQ</td>
<td align="left" valign="top">TCIP and anxiety <italic>r</italic>&#x202F;=&#x202F;&#x2212;0.03; MCQ and anxiety <italic>r</italic>&#x202F;=&#x202F;&#x2212;0.31 Not significant</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref86">Zhao et al. (2015)</xref>
</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">19.28</td>
<td align="left" valign="top">Caucasian</td>
<td align="center" valign="top">61.0%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Experimental, Cross-sectional</td>
<td align="left" valign="top">STAI</td>
<td align="left" valign="top">MCQ</td>
<td align="left" valign="top">Anxiety trait x state <italic>&#x03B2;</italic>&#x202F;=&#x202F;&#x2212;0.222 <italic>p</italic>&#x202F;=&#x202F;0.034</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref31">Hurlemann et al. (2019)</xref>
</td>
<td align="center" valign="top">70</td>
<td align="center" valign="top">31.21; 11.43 and 34.46; 14.45</td>
<td align="left" valign="top">Netherlands</td>
<td align="center" valign="top">80.0%</td>
<td align="left" valign="top">SAD</td>
<td align="left" valign="top">Experimental, Cross-sectional</td>
<td align="left" valign="top">SPAI</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top">Higher discount rate in SAD group vs. control.</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref33">Jenks and Lawyer (2015)</xref>
</td>
<td align="center" valign="top">113</td>
<td align="center" valign="top">25.1; 8.2 and 26.4; 8.8</td>
<td align="left" valign="top">Caucasian</td>
<td align="center" valign="top">67.0%</td>
<td align="left" valign="top">SAD</td>
<td align="left" valign="top">Experimental, Cross-sectional</td>
<td align="left" valign="top">SIAS and Subjective measure</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top">The induction of anxiety did not result in a higher discount rate</td>
</tr>
<tr>
<td align="left" valign="top">
<xref ref-type="bibr" rid="ref27">Gui et al. (2023)</xref>
</td>
<td align="center" valign="top">439</td>
<td align="center" valign="top">Adults</td>
<td align="left" valign="top">Chinese</td>
<td align="center" valign="top">57.5%</td>
<td align="left" valign="top">No</td>
<td align="left" valign="top">Varied</td>
<td align="left" valign="top">STAI</td>
<td align="left" valign="top">Ad hoc design</td>
<td align="left" valign="top"><italic>r</italic> =&#x202F;&#x2212;0.581 between state anxiety and decision weight on MoneyDiff</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>&#x002A;Features reported differed in country and ethnics among publications. &#x002A;&#x002A;CASI, Childhood Anxiety Sensitivity Index; MCQ, Monetary choice Questionnaire; STAI, State Trait Anxiety Inventory; CCAPS, Counselling Centre Assessment of Psychological Symptoms; DASS, Depression Anxiety and Stress Scale; K-SADS, Kiddie Schedule for Affective Disorders and Schizophrenia; ADT-5, 5-Trial Adjusting Delay Discounting Task; BAI, Beck Anxiety Inventory; DGI, Delaying Gratification Inventory; ADOG, Academic Delay of Gratification; TCIP, Two-Choice Impulsivity Paradigm; PHQ-9, Patient Health Questionnaire; PHQ-Anx, Patient Health Questionnaire Anxiety Subscale; SPAI, Social Phobia and Anxiety Inventory; GAD, Generalised Anxiety Disorder Scale; DAS-E, 53-item extended Death Anxiety Scale; QDQ, Quick Delay Questionnaire; SIAS, Social Interaction Anxiety Scale; SAD, Social anxiety disorder; HED, Heavy episodic drinking; AN, Anorexia nervosa; OCD, Obsessive-compulsive disorder.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec10">
<label>2.4</label>
<title>Data collection process</title>
<p>The extracted data included the following characteristics: sample size, age and standard deviation, nationality, sex ratio, and diagnosis; study type; measure of anxiety; measure of delay discounting; and main outcomes of interest.</p>
</sec>
</sec>
<sec sec-type="results" id="sec11">
<label>3</label>
<title>Results</title>
<sec id="sec12">
<label>3.1</label>
<title>Study type</title>
<p>The present review identified 18 studies that employed an observational methodology, six with experimental designs, and a last one of a mixed methods approach.</p>
<p>Of the 25 studies included, only one employed a longitudinal methodology, while the remainder employed a cross-sectional approach. Anxiety was assessed using a variety of instruments, with the most frequently employed being the State&#x2013;Trait Anxiety Inventory (7; <xref ref-type="bibr" rid="ref73">Spielberger et al., 1983</xref>) the Depression Anxiety and Stress Scale (4; <xref ref-type="bibr" rid="ref51">Lovibond and Lovibond, 1995</xref>), the Generalised Anxiety Disorder Scale (4; <xref ref-type="bibr" rid="ref35">Johnson et al., 2019</xref>), and the Patient Health Questionnaire (4; <xref ref-type="bibr" rid="ref7">Arroll et al., 2010</xref>). With regard to the assessment of DG, an <italic>Ad Hoc</italic> design was utilised in the majority of studies (10), followed by the Monetary Choice Questionnaire (5; <xref ref-type="bibr" rid="ref39">Kirby and Marakovi&#x0107;, 1996</xref>) and the Adjusting Delay Discounting Task (4; <xref ref-type="bibr" rid="ref42">Koffarnus and Bickel, 2014</xref>).</p>
</sec>
<sec id="sec13">
<label>3.2</label>
<title>Sample features</title>
<p>The total number of subjects included in the 25 studies reviewed was 12,728, with an age range of 13 to 69&#x202F;years and a sex ratio that varied from 0 to 100% female. The samples encompass a diverse range of nationalities, with the most prevalent being the United States and China (<xref ref-type="bibr" rid="ref15">Campbell and Egede, 2023</xref>; <xref ref-type="bibr" rid="ref29">Haines et al., 2020</xref>; <xref ref-type="bibr" rid="ref34">Jiao et al., 2022</xref>; <xref ref-type="bibr" rid="ref50">Li et al., 2023</xref>; <xref ref-type="bibr" rid="ref57">Minhas et al., 2020</xref>; <xref ref-type="bibr" rid="ref74">Steinglass et al., 2017</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>, <xref ref-type="bibr" rid="ref82">2023</xref>; <xref ref-type="bibr" rid="ref84">Zampella and Benau, 2022</xref>; <xref ref-type="bibr" rid="ref85">Zhang et al., 2020</xref>) followed by Italy, the United Kingdom, and Vietnam (<xref ref-type="bibr" rid="ref30">Ho et al., 2023</xref>; <xref ref-type="bibr" rid="ref61">Nigro et al., 2017</xref>; <xref ref-type="bibr" rid="ref68">Robertson et al., 2023</xref>).</p>
<p>The ethnical consideration of subjects varied widely among studies. Three of them (<xref ref-type="bibr" rid="ref27">Gui et al., 2023</xref>; <xref ref-type="bibr" rid="ref31">Hurlemann et al., 2019</xref>; <xref ref-type="bibr" rid="ref47">Levitt et al., 2023</xref>) only specified the geographical origin of the sample, rather than nationality or ethnicity, while others chose to specify the ethnic background of the sample- Within that latter type, the majority of subjects were Caucasian, although there were also smaller percentages of Hispanic, Asian, and African American populations (<xref ref-type="bibr" rid="ref21">DeRosa et al., 2023</xref>; <xref ref-type="bibr" rid="ref24">Gerhart et al., 2016</xref>; <xref ref-type="bibr" rid="ref33">Jenks and Lawyer, 2015</xref>; <xref ref-type="bibr" rid="ref46">Levin et al., 2018</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref86">Zhao et al., 2015</xref>). Finally, two studies did not report this information (<xref ref-type="bibr" rid="ref58">Morasco et al., 2019</xref>; <xref ref-type="bibr" rid="ref64">Patt et al., 2021</xref>).</p>
<p>Lastly, regarding the clinical aspect of samples, a total of 15 samples were drawn from the general population (<xref ref-type="bibr" rid="ref27">Gui et al., 2023</xref>; <xref ref-type="bibr" rid="ref30">Ho et al., 2023</xref>, p. 23; <xref ref-type="bibr" rid="ref34">Jiao et al., 2022</xref>; <xref ref-type="bibr" rid="ref46">Levin et al., 2018</xref>; <xref ref-type="bibr" rid="ref47">Levitt et al., 2023</xref>; <xref ref-type="bibr" rid="ref50">Li et al., 2023</xref>, p. 23; <xref ref-type="bibr" rid="ref64">Patt et al., 2021</xref>; <xref ref-type="bibr" rid="ref68">Robertson et al., 2023</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>, <xref ref-type="bibr" rid="ref82">2023</xref>; <xref ref-type="bibr" rid="ref84">Zampella and Benau, 2022</xref>; <xref ref-type="bibr" rid="ref85">Zhang et al., 2020</xref>; <xref ref-type="bibr" rid="ref86">Zhao et al., 2015</xref>), and only nine reports were included focusing on clinical or subclinical samples with various pathologies (<xref ref-type="bibr" rid="ref15">Campbell and Egede, 2023</xref>; <xref ref-type="bibr" rid="ref21">DeRosa et al., 2023</xref>; <xref ref-type="bibr" rid="ref24">Gerhart et al., 2016</xref>; <xref ref-type="bibr" rid="ref29">Haines et al., 2020</xref>; <xref ref-type="bibr" rid="ref31">Hurlemann et al., 2019</xref>; <xref ref-type="bibr" rid="ref33">Jenks and Lawyer, 2015</xref>; <xref ref-type="bibr" rid="ref57">Minhas et al., 2020</xref>; <xref ref-type="bibr" rid="ref58">Morasco et al., 2019</xref>; <xref ref-type="bibr" rid="ref61">Nigro et al., 2017</xref>; <xref ref-type="bibr" rid="ref74">Steinglass et al., 2017</xref>).</p>
</sec>
<sec id="sec14">
<label>3.3</label>
<title>Anxiety and DD</title>
<p>Of the studies reviewed, 16 provided evidence in favour of the existence of a positive association between anxiety and DD. This evidence suggests that higher levels of anxiety are related to higher discount rate, which means a lower ability of subjects to delay gratification. Significant associations supporting this hypothesis were identified in 12 of the papers (<xref ref-type="bibr" rid="ref15">Campbell and Egede, 2023</xref>; <xref ref-type="bibr" rid="ref24">Gerhart et al., 2016</xref>; <xref ref-type="bibr" rid="ref30">Ho et al., 2023</xref>; <xref ref-type="bibr" rid="ref34">Jiao et al., 2022</xref>; <xref ref-type="bibr" rid="ref46">Levin et al., 2018</xref>; <xref ref-type="bibr" rid="ref47">Levitt et al., 2023</xref>; <xref ref-type="bibr" rid="ref58">Morasco et al., 2019</xref>; <xref ref-type="bibr" rid="ref61">Nigro et al., 2017</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>, <xref ref-type="bibr" rid="ref82">2023</xref>, p. 23; <xref ref-type="bibr" rid="ref84">Zampella and Benau, 2022</xref>; <xref ref-type="bibr" rid="ref85">Zhang et al., 2020</xref>), Two studies did not provide the corresponding statistical analysis (<xref ref-type="bibr" rid="ref31">Hurlemann et al., 2019</xref>; <xref ref-type="bibr" rid="ref57">Minhas et al., 2020</xref>) while two others reported non-significant associations (<xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>).</p>
<p>Two of the studies reviewed yielded evidence that contradicts the hypothesis proposed in this study. In contrast with the hypothesis proposed in this study, <xref ref-type="bibr" rid="ref50">Li et al. (2023)</xref> discovered negative, albeit non-significant, correlations between Immediate Choice Ratios (ICR) calculated from the MCQ test and anxiety sensitivity obtained from the Childhood Anxiety Sensitivity Index instrument. This suggests that as anxiety sensitivity increases, the percentage of times the immediate option is selected decreases. Conversely, <xref ref-type="bibr" rid="ref33">Jenks and Lawyer (2015)</xref> observed no significant increase in the discount rate in either the control or experimental group when anxiety was induced through public speaking in subjects with social anxiety disorder.</p>
<p>With regard to the remaining articles under review, the results are inconclusive (<xref ref-type="bibr" rid="ref21">DeRosa et al., 2023</xref>). Furthermore, the interactions between factors are complex and require further elucidation. <xref ref-type="bibr" rid="ref29">Haines et al. (2020)</xref> observed that high state anxiety scores were a reliable predictor of a devaluation of reinforcement in participants. Moreover, anxiety was demonstrated to act as a robust mediator between impulsivity and discounting rates, rather than exerting a direct influence on discounting rates. A statistical analysis of all participants in the <xref ref-type="bibr" rid="ref74">Steinglass et al. (2017)</xref> study revealed a negative correlation between discounting rates and anxiety. However, the group with a diagnosis of Social Anxiety Disorder exhibited higher delay discounting rates than healthy controls. In contrast, the experimental design proposed by <xref ref-type="bibr" rid="ref64">Patt et al. (2021)</xref> to investigate intertemporal choices across an experiential and a hypothetical task revealed disparate associations between state anxiety and trait anxiety with these tasks. Specifically, state anxiety was found to be positively associated with the discount rate in the experiential task, while no correlation was observed between the discount rates of the experiential and hypothetical tasks.</p>
<p>The study by <xref ref-type="bibr" rid="ref68">Robertson et al. (2023)</xref> revealed no correlation between anxiety and discount rate. However, the researchers did identify a relationship between anxiety and temporal representation through language. In contrast, the study by <xref ref-type="bibr" rid="ref27">Gui et al. (2023)</xref> employed the Drift Diffusion Model (DDM) to investigate delay discounting. Their findings indicated a significant correlation between state anxiety and the weight assigned to monetary differences in decision-making. This suggests that individuals with high state anxiety may devalue monetary differences and exhibit increased impulsivity.</p>
<p>In the study by <xref ref-type="bibr" rid="ref86">Zhao et al. (2015)</xref> a significant interaction between state and trait anxiety was observed. Individuals with high state and trait anxiety exhibited a tendency to choose delayed rewards, whereas those with high trait anxiety but low state anxiety demonstrated a preference for more immediate rewards.</p>
</sec>
<sec id="sec15">
<label>3.4</label>
<title>Risk of bias</title>
<p>The demographic characteristics of some studies compromise the external validity of the results. Of the 25 studies reviewed, 6 did not reach a sample size of 100 (<xref ref-type="bibr" rid="ref31">Hurlemann et al., 2019</xref>; <xref ref-type="bibr" rid="ref58">Morasco et al., 2019</xref>; <xref ref-type="bibr" rid="ref64">Patt et al., 2021</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>) and 4 only slightly exceeded it (<xref ref-type="bibr" rid="ref33">Jenks and Lawyer, 2015</xref>; <xref ref-type="bibr" rid="ref74">Steinglass et al., 2017</xref>; <xref ref-type="bibr" rid="ref85">Zhang et al., 2020</xref>; <xref ref-type="bibr" rid="ref86">Zhao et al., 2015</xref>) which could jeopardize their representativeness.</p>
<p>A mere six of the papers subjected to review opted for an experimental design (<xref ref-type="bibr" rid="ref31">Hurlemann et al., 2019</xref>; <xref ref-type="bibr" rid="ref33">Jenks and Lawyer, 2015</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>; <xref ref-type="bibr" rid="ref86">Zhao et al., 2015</xref>). The interpretation of results in observational studies is susceptible to bias due to the lack of control over variables. Additionally, the six papers included in this review have relatively small sample sizes, which could introduce further bias into the overall results.</p>
<p>One of the characteristics extracted from the studies presented in <xref ref-type="table" rid="tab1">Table 1</xref> is the diagnosis of the sample. It should be noted, however, that two of the nine studies with clinical samples did not carry out an actual diagnostic process of the pathology (<xref ref-type="bibr" rid="ref33">Jenks and Lawyer, 2015</xref>; <xref ref-type="bibr" rid="ref61">Nigro et al., 2017</xref>). Rather, the sample was selected or assigned to the control or experimental group based on the scores obtained in validated questionnaires. The remaining studies reviewed did, however, carry out this process (<xref ref-type="bibr" rid="ref15">Campbell and Egede, 2023</xref>; <xref ref-type="bibr" rid="ref21">DeRosa et al., 2023</xref>; <xref ref-type="bibr" rid="ref24">Gerhart et al., 2016</xref>; <xref ref-type="bibr" rid="ref29">Haines et al., 2020</xref>; <xref ref-type="bibr" rid="ref31">Hurlemann et al., 2019</xref>; <xref ref-type="bibr" rid="ref58">Morasco et al., 2019</xref>; <xref ref-type="bibr" rid="ref74">Steinglass et al., 2017</xref>). The aforementioned variability in sample selection may result in the drawing of conclusions regarding the population in question that are biased in one way or another.</p>
<p>The incorporation of a control group is a crucial element in research, as it enhances the reliability and validity of the findings. A review of the 24 studies revealed that 14 of them lacked a control group, thereby preventing a comparison of the results of their observations (<xref ref-type="bibr" rid="ref21">DeRosa et al., 2023</xref>; <xref ref-type="bibr" rid="ref24">Gerhart et al., 2016</xref>; <xref ref-type="bibr" rid="ref30">Ho et al., 2023</xref>; <xref ref-type="bibr" rid="ref46">Levin et al., 2018</xref>; <xref ref-type="bibr" rid="ref47">Levitt et al., 2023</xref>; <xref ref-type="bibr" rid="ref50">Li et al., 2023</xref>; <xref ref-type="bibr" rid="ref61">Nigro et al., 2017</xref>; <xref ref-type="bibr" rid="ref64">Patt et al., 2021</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>, <xref ref-type="bibr" rid="ref82">2023</xref>; <xref ref-type="bibr" rid="ref84">Zampella and Benau, 2022</xref>; <xref ref-type="bibr" rid="ref85">Zhang et al., 2020</xref>). Although the majority of the studies were conducted in the general population, the inclusion of a comparative group outside the study population could have been beneficial.</p>
<p>A significant source of bias is the considerable heterogeneity in the assessment of both DD and anxiety across the reviewed studies. On the one hand, the majority of studies employ an <italic>ad hoc</italic> design for the assessment of DD. For the remaining studies, only two tests are utilised by more than one study. While the fundamental paradigm of the tests is consistent, the specific characteristics vary, which may influence the results, as illustrated in the study by <xref ref-type="bibr" rid="ref64">Patt et al. (2021)</xref>. A similar phenomenon is observed in the anxiety measures. Despite the use of standardised measures in all but one study (<xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>) the variability in measurement methods considerably reduces the reliability of the results.</p>
</sec>
</sec>
<sec sec-type="discussion" id="sec16">
<label>4</label>
<title>Discussion</title>
<p>The operational objectives of this review were to examine the recent results on correlation between delay discounting and anxiety, and secondly, to actualise and disambiguate the underlying mechanisms that may be responsible for this association.</p>
<p>As hitherto explained, the relationship between subjects with social anxiety has previously been evaluated with contradictory results among different research studies (<xref ref-type="bibr" rid="ref6">Armstrong and Hoge, 2024</xref>; <xref ref-type="bibr" rid="ref69">Rounds et al., 2007</xref>) and the underlaying mechanism is yet to fully discover (<xref ref-type="bibr" rid="ref49">Li et al., 2019</xref>; <xref ref-type="bibr" rid="ref56">Mertens et al., 2025</xref>; <xref ref-type="bibr" rid="ref78">Ust&#x00E1;rroz and Grandi, 2016</xref>).</p>
<p>A recent study conducted in Canada with a considerably larger sample size identified more pronounced discount rates among subjects diagnosed with Social Anxiety Disorder, Post-Traumatic Stress Disorder, and Generalised Anxiety Disorder when compared to healthy controls. However, these differences were not replicated in subjects diagnosed with Panic Disorder and Obsessive-Compulsive Disorder (<xref ref-type="bibr" rid="ref13">Boyd et al., 2024</xref>). These results align with those of other studies, indicating that the interplay between anxiety and DD may not follow a uniform pattern across all disorders (<xref ref-type="bibr" rid="ref2">Amlung et al., 2019</xref>; <xref ref-type="bibr" rid="ref74">Steinglass et al., 2017</xref>). This suggests that even within the domain of anxiety disorders, the association between these two phenomena may not be consistent.</p>
<sec id="sec17">
<label>4.1</label>
<title>Anxiety and DD in general population</title>
<p>A lower DD rate among low-anxious versus high-anxious subjects has been found in 10 out of 15 general population studies (<xref ref-type="bibr" rid="ref30">Ho et al., 2023</xref>, p. 23; <xref ref-type="bibr" rid="ref34">Jiao et al., 2022</xref>; <xref ref-type="bibr" rid="ref46">Levin et al., 2018</xref>; <xref ref-type="bibr" rid="ref47">Levitt et al., 2023</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>; <xref ref-type="bibr" rid="ref80">Worthy et al., 2014</xref>; <xref ref-type="bibr" rid="ref81">Xia et al., 2017</xref>, <xref ref-type="bibr" rid="ref82">2023</xref>; <xref ref-type="bibr" rid="ref84">Zampella and Benau, 2022</xref>; <xref ref-type="bibr" rid="ref85">Zhang et al., 2020</xref>). These studies provide evidence in favour of the existence of a positive relationship between anxiety and DD. Furthermore, additional noteworthy findings pertaining to this relationship have been identified in four of the remaining five articles (<xref ref-type="bibr" rid="ref27">Gui et al., 2023</xref>; <xref ref-type="bibr" rid="ref64">Patt et al., 2021</xref>; <xref ref-type="bibr" rid="ref68">Robertson et al., 2023</xref>; <xref ref-type="bibr" rid="ref86">Zhao et al., 2015</xref>). While these findings do not directly indicate a direct correlation between DD and anxiety, they do contribute valuable insights that enhance the comprehension of this relationship. In relation to the general population, the evidence presented in this review is sufficient to affirm that there is a positive association between DD and anxiety in people with gambling disorder. In other words, elevated anxiety levels are associated with reduced capacity to delay gratification in individuals, a phenomenon that appears to be generalisable across different ethnicities and nationalities, as well as to both sexes. This effect is observed consistently across studies, despite the wide range of anxiety and DD measures employed. These findings provide preliminary evidence for this relationship in the general population, although further research is needed to substantiate these observations.</p>
</sec>
<sec id="sec18">
<label>4.2</label>
<title>Anxiety and DD through medical illnesses</title>
<p>The three studies on medical illnesses included in this review indicate that anxiety is positive related to DD among these subjects. This finding is analogous to that observed in the general population sample. These results align with those reported in previous research (<xref ref-type="bibr" rid="ref19">Craft et al., 2020</xref>; <xref ref-type="bibr" rid="ref22">Epstein et al., 2021</xref>). They suggest that this construct is a fundamental aspect to be considered in the development of more effective intervention protocols that take into account aspects of patients&#x2019; psychology.</p>
</sec>
<sec id="sec19">
<label>4.3</label>
<title>Anxiety and DD in addictions</title>
<p>The close relationship between delay discounting and patients with various addictions is well established in the literature (<xref ref-type="bibr" rid="ref52">MacKillop et al., 2011</xref>; <xref ref-type="bibr" rid="ref79">Weinsztok et al., 2021</xref>). Nevertheless, further research is required to substantiate the existence of an altered pattern of delay discounting that is a common feature of all addictive disorders. Furthermore, it would be beneficial to incorporate a range of terminologies beyond DD to ensure the inclusion of diverse approaches to the study of this paradigm. The DD paradigm has facilitated a more nuanced understanding of addictive mechanisms in both substance and non-substance addictions. The direction of this relationship is not yet entirely clear, although this is beyond the scope of this review. However, the results of the three studies included in this review related to addictions are in line with studies specific to this subject (<xref ref-type="bibr" rid="ref4">Amlung et al., 2017</xref>; <xref ref-type="bibr" rid="ref43">Konecky and Lawyer, 2015</xref>).</p>
</sec>
<sec id="sec20">
<label>4.4</label>
<title>Anxiety and DD in social anxiety disorder</title>
<p>The study of the role of DD among people with social anxiety disorder has yielded conflicting evidence (<xref ref-type="bibr" rid="ref6">Armstrong and Hoge, 2024</xref>; <xref ref-type="bibr" rid="ref13">Boyd et al., 2024</xref>). In our analysis, two of the three studies have indicated a positive correlation between SAD and DD. Both <xref ref-type="bibr" rid="ref31">Hurlemann et al. (2019)</xref> and <xref ref-type="bibr" rid="ref74">Steinglass et al. (2017)</xref> identified a positive correlation between a SAD diagnosis and a higher discounting rate. This indicates that individuals with this diagnosis discount delayed reinforcement more strongly, thereby demonstrating a preference for immediate and smaller rewards. Conversely, <xref ref-type="bibr" rid="ref33">Jenks and Lawyer (2015)</xref> employed an experimental design in which anxiety was induced through a public speaking task and observed no variation in discounting rates in either the experimental group with this diagnosis or the control group. A synthesis of these findings suggests that the increase in the discount rate may not be a consequence of anxiety, but rather a potential causal factor. While correlational studies offer valuable insights into a phenomenon, experimental designs are essential for elucidating the underlying mechanisms of observed correlations.</p>
</sec>
<sec id="sec21">
<label>4.5</label>
<title>DD and trait&#x2013;state anxiety</title>
<p>The interaction between state and trait anxiety (<xref ref-type="bibr" rid="ref86">Zhao et al., 2015</xref>) offers an intriguing perspective on the role of DD in anxiety experience. Therefore, individuals with high trait anxiety may be more susceptible to exhibiting a risk perception bias for delayed rewards during periods of elevated anxiety compared to periods of low anxiety. Consequently, they may opt for immediate, albeit modest rewards due to the fear of missing out on larger, albeit more delayed rewards. Those with low trait anxiety are less susceptible to this bias, demonstrating superior performance even in high-anxiety contexts (<xref ref-type="bibr" rid="ref37">Kim et al., 2020</xref>; <xref ref-type="bibr" rid="ref62">Notebaert et al., 2016</xref>). <xref ref-type="bibr" rid="ref29">Haines et al. (2020)</xref> propose that there may be an interaction between individuals&#x2019; experienced anxiety and their impulsivity-trait, with the latter influencing the speed at which subjects discount rewards. This implies that the devaluation of reinforcement shown by individuals with high state anxiety could produce more random responses in the DD paradigm, which would limit the validity of the results.</p>
</sec>
<sec id="sec22">
<label>4.6</label>
<title>Temporal representation, anxiety and DD</title>
<p>Conversely, it is conceivable that individuals with elevated anxiety levels may exhibit heightened discounting tendencies, not directly, but through a more distanced representation of the future that mediates the experience of anxiety and DD (<xref ref-type="bibr" rid="ref68">Robertson et al., 2023</xref>). The role of temporal representation as a mediator requires further investigation in future studies. The direction of causality in this relationship, namely whether anxiety produces this temporal distortion or whether it is the temporal distortion that influences the development and experience of anxiety, remains unclear. Furthermore, this relationship has been studied through the lens of language. While the relationship between the use of verbal forms and decision-making is assumed (<xref ref-type="bibr" rid="ref10">Banerjee and Urminsky, 2022</xref>), it would be beneficial to explore other paradigms.</p>
</sec>
<sec id="sec23">
<label>4.7</label>
<title>Anxiety and drift diffusion model</title>
<p>An alternative and more recent approach to the delay discounting paradigm is the Drift Diffusion Model (DDM), which integrates a greater number of variables than the traditional DD paradigm. The traditional DD paradigm employs the parameter k (discount rate) to evaluate this process. However, this parameter does not adequately reflect the complexity of the trade-off between delay and magnitude of reinforcement. In a study conducted by <xref ref-type="bibr" rid="ref27">Gui et al. (2023)</xref> the influence of smartphone addiction and anxiety on impulsive decision-making was investigated through the lens of the DDM. The findings revealed a significant correlation between monetary differences in decision weight and anxiety, but not between anxiety and the difference in reward delay. These findings provide further insight into the cognitive mechanisms underlying the intertemporal decision process, indicating substantial variability between individuals with high and low state anxiety with respect to the balance they consider optimal for making a decision between immediate and small versus delayed and larger rewards. That is, the temporal delay of these rewards is of lesser importance than the magnitude of the delayed reward, such that a larger magnitude increase in reinforcement is required to compensate for the delay.</p>
</sec>
<sec id="sec24">
<label>4.8</label>
<title>Test features and discount rates</title>
<p>In the course of this review, a multitude of methodologies for measuring DD have been employed, all of which are predicated on the dichotomy between immediate, albeit modest, rewards and those that are delayed and of a greater magnitude. However, the specific characteristics of the test appear to be relevant to the resulting outcome. The evidence suggests that individuals&#x2019; performance on tasks varies depending on whether they are behavioural or hypothetical tasks (<xref ref-type="bibr" rid="ref64">Patt et al., 2021</xref>). The studies included in this review employ both types of tasks; however, the majority are hypothetical. This could indicate that participants do not demonstrate their true delay of gratification ability in hypothetical tasks due to a lack of real motivational incentives that they otherwise encounter in experiential paradigms or in their own daily lives. Other possibilities could be the overestimation of one&#x2019;s own capabilities in hypothetical situations or the emotional influence of real situations on decision-making.</p>
</sec>
</sec>
<sec sec-type="conclusions" id="sec25">
<label>5</label>
<title>Conclusion</title>
<p>The role of reinforcers has been the subject of extensive study within the field of addiction. It is perhaps unsurprising that this concept of delay discounting has been the subject of extensive exploration and development within this context. However, reinforcement processes are fundamental to understanding any pathology, from mood or anxiety disorders to sexual or eating disorders. Therefore, it seems worthwhile to consider the capacity of patients with such pathologies to delay gratification in order to gain insight into their relationship with reinforcers in their lives. In general, it appears that individuals with anxiety disorders exhibit a reduced capacity to delay gratification, although the precise nature of this phenomenon remains unclear.</p>
<p>Firstly, there is a need for further research utilising experimental and longitudinal designs with the objective of providing insight into the direction of causality between anxiety and DD. Secondly, further studies, such as that conducted by <xref ref-type="bibr" rid="ref60">Murray et al. (2018)</xref> are required in both adult, child and adolescent populations. These studies should analyse the lifelong stability of DD, as well as its modifiability through specific techniques. Finally, the potential existence of mediators between anxiety and DD should be evaluated in order to facilitate a more precise understanding of this relationship. Some authors (<xref ref-type="bibr" rid="ref26">Greenhow et al., 2015</xref>; <xref ref-type="bibr" rid="ref76">Tanovic et al., 2018</xref>) have put forth the notion of intolerance to uncertainty as a potential mediator. Conversely, other authors (<xref ref-type="bibr" rid="ref68">Robertson et al., 2023</xref>) have proposed temporal representation as a possible mechanism. <xref ref-type="bibr" rid="ref80">Worthy et al. (2014)</xref> have posited that it is specifically worry, rather than anxiety, that is directly related to DD. Nevertheless, further research in this area is warranted.</p>
<p>The majority of studies of this review have identified a positive correlation between DD and anxiety. This indicates that individuals with elevated anxiety levels tend to exhibit reduced capacity to delay gratification. In other words, those with heightened anxiety tend to prioritise immediate, albeit smaller, rewards over larger, delayed rewards. The sample size of this review is insufficient to permit the same confidence in this claim for the clinical population. However, the results obtained suggest that people with a psychological disorder or people undergoing treatment for a medical illness could also follow the same pattern, except in people with some pathologies such as obsessive-compulsive disorder or anorexia nervosa.</p>
</sec>
<sec id="sec26">
<label>6</label>
<title>Limitations</title>
<p>It is important to acknowledge the limitations of this review. It is recommended that the conclusions drawn from the results be considered with caution. Given the considerable heterogeneity of the measures identified and the dearth of research on this topic in the existing literature, it was not feasible to conduct a meta-analysis of the results. It is recommended that future research include stricter article selection criteria to make meta-analysis possible. However, additional research with observational and experimental designs should also be conducted to contribute to the existing literature on the relationship between anxiety and DD. Furthermore, it is generally advised that at least two independent reviewers be engaged to conduct the screening, selection and eligibility process separately. The research resources available for the present study necessitated the process to be carried out by a single reviewer.</p>
<p>Secondly, although it can be concluded that there is a positive association between DD and anxiety in the general population, the specific mechanisms underlying this association remain to be explored and are beyond the scope of this study.</p>
<p>Thirdly, it has not been feasible to incorporate a sufficient range and quantity of articles examining a diverse array of pathologies into this review to substantiate a definitive conclusion regarding the relationship between anxiety and DD in the clinical population. While the available evidence suggests a potential association, further research with higher methodological standards is required to confirm this.</p>
<p>Fourthly, the extensive range of measurement instruments employed in the studies reviewed represents a significant limitation. Some of the instruments employed, such as the Childhood Anxiety Sensitivity Index, do not specifically assess the experience of anxiety. Furthermore, the Death Anxiety Scale and the Social Interaction Anxiety Scale focus on the experience of anxiety in specific contexts or situations. The measures of these instruments are not an accurate reflection of the experience of anxiety in the moment, which is the purpose of this research. Furthermore, there is even greater heterogeneity in the measures used to assess DD. In future reviews, when research in this field is more prolific, it would be beneficial to restrict the selection of items to those using the same measure.</p>
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</body>
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<sec sec-type="data-availability" id="sec27">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="author-contributions" id="sec28">
<title>Author contributions</title>
<p>MDR: Validation, Writing &#x2013; original draft, Investigation, Writing &#x2013; review &#x0026; editing, Resources, Formal analysis, Project administration, Data curation, Visualization, Methodology, Supervision, Conceptualization. CVH: Writing &#x2013; review &#x0026; editing, Investigation, Methodology, Resources, Formal analysis, Validation, Data curation, Project administration, Supervision, Visualization, Conceptualization.</p>
</sec>

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<title>Conflict of interest</title>
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<title>Generative AI statement</title>
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</sec>
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</ref-list><fn-group><fn id="fn0001" fn-type="custom" custom-type="edited-by"><p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/431709/overview">Fabien Gierski</ext-link>, Universit&#x00E9; de Reims Champagne-Ardenne, France</p></fn>
<fn id="fn0002" fn-type="custom" custom-type="reviewed-by"><p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/527848/overview">Jun Li</ext-link>, Northwest Normal University, China</p><p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1081710/overview">Marta Leuenberger</ext-link>, University of Basel, Switzerland</p></fn></fn-group></back>
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