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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychol.</journal-id>
<journal-title>Frontiers in Psychology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychol.</abbrev-journal-title>
<issn pub-type="epub">1664-1078</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyg.2023.1193441</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychology</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Three joint temperament-character configurations account for learning, personality and well-being: normative demographic findings in a representative national population</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Moreira</surname>
<given-names>Paulo A. S.</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<xref rid="aff2" ref-type="aff"><sup>2</sup></xref>
<xref rid="c001" ref-type="corresp"><sup>&#x002A;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2218466/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Inman</surname>
<given-names>Richard A.</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<xref rid="aff2" ref-type="aff"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/459473/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cloninger</surname>
<given-names>C. Robert</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/71159/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Centro de Investiga&#x00E7;&#x00E3;o em Psicologia para o Desenvolvimento (CIPD)</institution>, <addr-line>Lisbon</addr-line>, <country>Portugal</country></aff>
<aff id="aff2"><sup>2</sup><institution>Instituto de Psicologia e Ci&#x00EA;ncias da Educa&#x00E7;&#x00E3;o, Universidade Lus&#x00ED;ada</institution>, <addr-line>Porto</addr-line>, <country>Portugal</country></aff>
<author-notes>
<fn id="fn0001" fn-type="edited-by">
<p>Edited by: Leonardo Carlucci, University of Studies G. d'Annunzio Chieti and Pescara, Italy</p>
</fn>
<fn id="fn0002" fn-type="edited-by">
<p>Reviewed by: Du&#x0161;anka Mitrovi&#x0107;, University of Novi Sad, Serbia; Jeong-Ho Seok, Yonsei University, Republic of Korea</p>
</fn>
<corresp id="c001">&#x002A;Correspondence: Paulo A. S. Moreira, <email>pmoreira@utad.pt</email>;<email>paulomoreira976@gmail.com</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>03</day>
<month>07</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>14</volume>
<elocation-id>1193441</elocation-id>
<history>
<date date-type="received">
<day>24</day>
<month>03</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>29</day>
<month>05</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2023 Moreira, Inman and Cloninger.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Moreira, Inman and Cloninger</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Introduction</title>
<p>A common practice in research and clinical practice is to use data considered representative of a target population to compare and understand the personality characteristics of specific groups or specific individuals. To this end, numerous studies have presented normative data for the temperament and character traits outlined in Cloninger&#x2019;s psychobiological model of personality. However, recent genomic evidence demonstrates that human personality is organized as a complex hierarchy that ascends beyond the individual traits to multi-trait profiles that regulate emotional reactivity (temperament profiles) or goals and values (character profiles), and then to three phenotypic networks, which integrate temperament profiles and character profiles, that regulate learning. Given this recent understanding, our aim was to provide a novel and more comprehensive description of personality features at a societal level (using a stratified sample representative of the Portuguese population) by considering personality at its higher levels of complexity.</p>
</sec>
<sec>
<title>Methods</title>
<p>Toward this goal, a stratified sample of 2,443 Portuguese adults responded to the Revised Temperament and Character Inventory (TCI-R).</p>
</sec>
<sec>
<title>Results</title>
<p>We summarize the prevalence of (a) temperament profiles, (b) character profiles, and (c) integrated temperament-character networks within the whole sample, as well as for men vs. women and different age groups separately. Independent of age and education, women were more likely to be capable of resourceful productivity and helpful cooperation combined with being more intuitive, meditative and creative than men. Independent of age and gender, individuals with a degree were also more likely to present these biopsychosocial features. We also found that the organized character profile was most typical of adults in their 40s. Finally, the distribution of personality profiles across age differed as a function of gender: for men the oldest individuals had the most coherent personalities while high personality integration was most prevalent for women in their 30s.</p>
</sec>
<sec>
<title>Discussion</title>
<p>These results have strong implications for research and intervention. In particular, these results are relevant for understanding the epidemiology of interactions between personality, mental health and well-being, including their expressions in a national population as a function of demographic characteristics.</p>
</sec>
</abstract>
<kwd-group>
<kwd>personality</kwd>
<kwd>temperament profiles</kwd>
<kwd>character profiles</kwd>
<kwd>temperament-character configurations</kwd>
<kwd>representative national population</kwd>
<kwd>epidemiology</kwd>
<kwd>personality and demographic interactions</kwd>
</kwd-group>
<counts>
<fig-count count="5"/>
<table-count count="7"/>
<equation-count count="0"/>
<ref-count count="75"/>
<page-count count="18"/>
<word-count count="11883"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Personality and Social Psychology</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="sec1" sec-type="intro">
<title>1. Introduction</title>
<p>The revised Temperament and Character Inventory (the TCI-R; <xref ref-type="bibr" rid="ref6">Cloninger, 1999</xref>) provides a reliable quantitative self-report assessment of the four temperament traits and three character traits described by Cloninger&#x2019;s psychobiological model of personality (<xref ref-type="bibr" rid="ref9">Cloninger, 2004</xref>). Reflecting its popularity and strong influence in generating research, the TCI-R has been translated into over 20 languages (e.g., <xref ref-type="bibr" rid="ref62">P&#x00E9;lissolo et al., 2005</xref>; <xref ref-type="bibr" rid="ref27">Goncalves and Cloninger, 2010</xref>; <xref ref-type="bibr" rid="ref56">Moreira et al., 2012</xref>, <xref ref-type="bibr" rid="ref38">2017</xref>), and has found to have at least as good (and often stronger) predictive validity than other modern personality inventories (<xref ref-type="bibr" rid="ref28">Grucza and Goldberg, 2007</xref>).</p>
<p>Recent studies have used various versions of the TCI-R to describe and understand how the personality features of specific groups of people vary relative to the general population (<xref ref-type="bibr" rid="ref67">Svrakic et al., 1993</xref>; <xref ref-type="bibr" rid="ref66">Sievert et al., 2016</xref>; <xref ref-type="bibr" rid="ref40">Moreira et al., 2019</xref>, <xref ref-type="bibr" rid="ref55">2022</xref>). Such research is useful because the neurobiologically-grounded traits of Cloninger&#x2019;s psychobiological model allow for causal explanations of experiences and actions at the individual level (<xref ref-type="bibr" rid="ref3">Cervone, 2005</xref>). However, for any meaningful interpretation of how the personality features of a subgroup or individual differ from normality it is necessary to have reliable normative data from a reference population. To this end, several studies have presented normative values for individual TCI-R traits and their facets (<xref ref-type="bibr" rid="ref48">Moreira et al., 2023a</xref>,<xref ref-type="bibr" rid="ref49">b</xref>).</p>
<p>However, robust genomic evidence has demonstrated that human personality is organized as a complex hierarchy that ascends beyond the individual traits to multi-trait profiles that regulate emotional reactivity (temperament profiles) or goals and values (character profiles), and then to three integrating temperament-character networks that express major systems of learning and memory (<xref ref-type="bibr" rid="ref16">Cloninger and Zwir, 2018</xref>, <xref ref-type="bibr" rid="ref17">2022</xref>; <xref ref-type="bibr" rid="ref71">Zwir et al., 2020a</xref>,<xref ref-type="bibr" rid="ref72">b</xref>, <xref ref-type="bibr" rid="ref73">2021</xref>, <xref ref-type="bibr" rid="ref74">2022</xref>). In light of this evidence, the purpose of the present article was to describe the prevalence of these more complex organizations of personality in a large and representative sample of Portuguese adults.</p>
<sec id="sec2">
<title>1.1. Temperament profiles</title>
<p>Firstly, the psychobiological model of personality posits a domain of relatively stable aspects of personality &#x2013; temperament - that captures heritable individual differences in dispositional tendencies to automatically and unconsciously react emotionally, act, and form attachments (<xref ref-type="bibr" rid="ref16">Cloninger and Zwir, 2018</xref>, <xref ref-type="bibr" rid="ref17">2022</xref>; <xref ref-type="bibr" rid="ref13">Cloninger et al., 2019</xref>; <xref ref-type="bibr" rid="ref72">Zwir et al., 2020b</xref>). Individual differences in temperament are quantified in terms of four dimensions that are neurophysiologically, neuroanatomically and biochemically distinct from one another: novelty seeking (impulsive and excitable vs. deliberate and reserved), harm avoidance (pessimistic and fearful vs. optimistic and risk-taking), reward dependence (sentimental and approval-seeking vs. objective and independent), and persistence (determined and ambitious vs. easily discouraged and underachieving) (<xref ref-type="bibr" rid="ref29">Gusnard et al., 2003</xref>; <xref ref-type="bibr" rid="ref34">Krebs et al., 2009</xref>; <xref ref-type="bibr" rid="ref72">Zwir et al., 2020b</xref>; <xref ref-type="bibr" rid="ref17">Cloninger and Zwir, 2022</xref>). All people have some latent level of each dimension, with both advantages and disadvantageous to the extremes of each depending on context, resulting in a high level of variability in temperament in the population.</p>
<p>Early clinical research showed that different clusters of personality disorders could be distinguished by these temperament dimensions: impulsive personality disorders (DSM Cluster B) linked to high novelty seeking; anxious-fearful personality disorders linked to high harm avoidance (DSM Cluster C); and aloof personality disorders linked to low reward dependence (DSM Cluster A) (<xref ref-type="bibr" rid="ref5">Cloninger, 1987</xref>; <xref ref-type="bibr" rid="ref67">Svrakic et al., 1993</xref>; <xref ref-type="bibr" rid="ref26">Goldman et al., 1994</xref>; <xref ref-type="bibr" rid="ref60">Mulder and Joyce, 1997</xref>). As such, configurations of novelty seeking, harm avoidance and reward dependence were presented as (and have been long used as) a reliable way to subtype personality disorders (<xref ref-type="bibr" rid="ref7">Cloninger, 2000</xref>) (see <xref rid="fig1" ref-type="fig">Figure 1</xref>). However, more recent research has demonstrated that heritability in temperament depends on genes that modulate molecular processes for associative conditioning and that developed early in the human evolutionary lineage (<xref ref-type="bibr" rid="ref17">Cloninger and Zwir, 2022</xref>), and that these genes code for different configurations of all four temperament dimensions (<xref ref-type="bibr" rid="ref16">Cloninger and Zwir, 2018</xref>; <xref ref-type="bibr" rid="ref13">Cloninger et al., 2019</xref>). In these profiles, individual differences in persistence (high vs. low) quantify the degree to which a person&#x2019;s habits and emotional tendencies are persistently regulated by the character traits to be coherent with goals and values (<xref ref-type="bibr" rid="ref47">Moreira et al., 2022c</xref>).</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>The temperament cube (Reproduced with permission of the copyright holder, Anthropedia Foundation).</p>
</caption>
<graphic xlink:href="fpsyg-14-1193441-g001.tif"/>
</fig>
<p>With the aim of evaluating the interactions among specific combinations of temperament traits related to human functioning and wellbeing, several recent studies have adopted person-centered approaches, clustering and comparing groups of individuals with similar temperament profiles. In many of these works, temperament profiles were formed by dividing the sample into participants above and below the median for novelty seeking (N vs. n), harm avoidance (H vs. h), reward dependence (R vs. r) and persistence (P vs. p) and then forming groups according to all 16 theoretically possible combinations of high and low temperament scores. Research comparing groups of people with different temperament profiles has found differences in average presentation of psychopathology, with configurations featuring high novelty seeking and low reward dependence and persistence (as well as slightly higher harm avoidance) linked to increased behavioral and emotional problems (<xref ref-type="bibr" rid="ref64">Rettew et al., 2008</xref>; <xref ref-type="bibr" rid="ref44">Moreira et al., 2021a</xref>,<xref ref-type="bibr" rid="ref50">b</xref>,<xref ref-type="bibr" rid="ref53">c</xref>,<xref ref-type="bibr" rid="ref58">d</xref>). Consistent with this work, an explosive temperament profile (NHr) with low persistence was found to occur more frequently in a prisoner population than the general population (<xref ref-type="bibr" rid="ref55">Moreira et al., 2022d</xref>). In contrast, configurations featuring high reward dependence and persistence with low novelty seeking and/or low harm avoidance have been linked to a lower average probability of psychopathology (<xref ref-type="bibr" rid="ref64">Rettew et al., 2008</xref>; <xref ref-type="bibr" rid="ref44">Moreira et al., 2021a</xref>,<xref ref-type="bibr" rid="ref50">b</xref>,<xref ref-type="bibr" rid="ref53">c</xref>,<xref ref-type="bibr" rid="ref58">d</xref>). Even within psychiatric samples, groups of patients with this type of temperament configuration were much more likely to be classed as having no subjective distress (<xref ref-type="bibr" rid="ref4">Choi and Lee, 2022</xref>). Other comparisons of groups of people with different temperament profiles has also shown that they differ in their average positive traits. For example, those with a methodical (nHr) temperament profile with high persistence tended to score highest for self-control, while others with an adventurous temperament profile with high persistence (Nhr) tended to score highest in inquisitiveness (<xref ref-type="bibr" rid="ref47">Moreira et al., 2022c</xref>). Further, individuals with a reliable temperament profile (nhR) and high persistence tended to report the highest subjective wellbeing, while those with an explosive temperament profile with low persistence tended to report the lowest subjective wellbeing. Validating the median-split approach to temperament profile formation, various studies employing mixture models or machine-learning algorithms have extracted similar latent temperament profiles, and shown that these differ in a theoretically consistent way in terms of well-being and human functioning (<xref ref-type="bibr" rid="ref43">Moreira and Inman, 2021</xref>; <xref ref-type="bibr" rid="ref73">Zwir et al., 2021</xref>; <xref ref-type="bibr" rid="ref44">Moreira et al., 2021a</xref>,<xref ref-type="bibr" rid="ref50">b</xref>,<xref ref-type="bibr" rid="ref53">c</xref>,<xref ref-type="bibr" rid="ref58">d</xref>; <xref ref-type="bibr" rid="ref45">Moreira and Inman, et al., 2022a</xref>,<xref ref-type="bibr" rid="ref50">b</xref>).</p>
</sec>
<sec id="sec3">
<title>1.2. Character profiles</title>
<p>Although groups of people with different temperament profiles differ in their average probabilities of having a personality disorder (vs. a mature and healthy personality) these average between-person effects alone were found to be uninformative for distinguishing the maturity or health of any specific individual (<xref ref-type="bibr" rid="ref14">Cloninger et al., 1997</xref>). In order to do so, the psychobiological model was expanded to include a regulatory and cognitive domain of personality, referred to as character, which recent research has confirmed is genetically, psychologically, and developmentally separate from temperament (<xref ref-type="bibr" rid="ref71">Zwir et al., 2020a</xref>), but similarly as heritable (<xref ref-type="bibr" rid="ref24">Gillespie et al., 2003</xref>; <xref ref-type="bibr" rid="ref17">Cloninger and Zwir, 2022</xref>). Human character reflects organizations of socio-cognitive processes for intentionality and self-awareness that serve functions that are intrapersonal (e.g., planning and foresight), legislative (e.g., empathy and norms for cooperation), and judicial (e.g., insight and intuitive evaluation of what is meaningful and good). Individual differences in these functions are quantified in terms of three dimensions for which all people have some latent value: self-directedness (responsible and purposeful vs. blaming and aimless), cooperativeness (tolerant and empathetic vs. prejudiced and self-centered) and self-transcendence (altruistic and spiritual vs. individualistic and skeptical). Critically, individual differences in these three character dimensions are what distinguish individuals with personality disorders from those without, with low self-directedness being a particularly strong indicator (<xref ref-type="bibr" rid="ref67">Svrakic et al., 1993</xref>).</p>
<p>Like for temperament, various studies have explored how interactions among specific combinations of character dimensions relate to human functioning and wellbeing. Similarly, for many works (e.g., <xref ref-type="bibr" rid="ref15">Cloninger and Zohar, 2011</xref>; <xref ref-type="bibr" rid="ref37">Moreira et al., 2015</xref>) character profiles were formed by dividing the sample into participants above and below the median for self-directedness (S vs. s), cooperativeness (C vs. c) and self-transcendence (T vs. t). This results in eight theoretical configurations of self-directedness, cooperativeness and self-transcendence, which can be depicted as the corners of a character cube (<xref ref-type="bibr" rid="ref9">Cloninger, 2004</xref>; see <xref rid="fig2" ref-type="fig">Figure 2</xref>). Supporting their naturalistic occurrence, all eight of these profiles have emerged from latent profile analyses (<xref ref-type="bibr" rid="ref45">Moreira et al., 2022a</xref>).</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>The character cube (Reproduced with permission of the copyright holder, Anthropedia Foundation).</p>
</caption>
<graphic xlink:href="fpsyg-14-1193441-g002.tif"/>
</fig>
<p>Various person-centered studies have demonstrated that physical, mental and social well-being is strongly dependent on one&#x2019;s configuration of character traits (<xref ref-type="bibr" rid="ref36">Moreira et al., 2008</xref>). From the eight possible profiles, the least healthy people typically have a profile with low self-directedness and cooperativeness. Consistent with this, research has shown that such character profiles are prevalent in prison inmates (<xref ref-type="bibr" rid="ref45">Moreira et al., 2022a</xref>,<xref ref-type="bibr" rid="ref46">b</xref>,<xref ref-type="bibr" rid="ref47">c</xref>,<xref ref-type="bibr" rid="ref55">d</xref>) and linked to elevated levels of emotional/behavioral problems (<xref ref-type="bibr" rid="ref35">Lee et al., 2018</xref>; <xref ref-type="bibr" rid="ref44">Moreira et al., 2021a</xref>) and psychological reactance (<xref ref-type="bibr" rid="ref46">Moreira et al., 2022b</xref>).</p>
<p>In contrast, profiles with high self-directedness and high cooperativeness describe people who are relatively healthy, although within this group of people those who also have high self-transcendence (the creative character) are typically happier, healthier, and more prosocial than those who have lower self-transcendence (the organized character) (<xref ref-type="bibr" rid="ref15">Cloninger and Zohar, 2011</xref>; <xref ref-type="bibr" rid="ref32">Josefsson et al., 2011</xref>; <xref ref-type="bibr" rid="ref11">Cloninger, 2013</xref>; <xref ref-type="bibr" rid="ref65">Sch&#x00FC;tz et al., 2013</xref>; <xref ref-type="bibr" rid="ref71">Zwir et al., 2020a</xref>; <xref ref-type="bibr" rid="ref48">Moreira et al., 2023a</xref>). Studies have shown that adolescents with a creative character are more engaged in school (<xref ref-type="bibr" rid="ref50">Moreira et al., 2021b</xref>) and more likely to adopt a deep approach to learning (<xref ref-type="bibr" rid="ref42">Moreira and Dias, 2019</xref>; <xref ref-type="bibr" rid="ref54">Moreira and Lee, 2020</xref>; <xref ref-type="bibr" rid="ref53">Moreira et al., 2021c</xref>); and that adults with this character are more likely to have a &#x2018;light&#x2019; sense of humor (including benevolent humor; <xref ref-type="bibr" rid="ref45">Moreira et al., 2022a</xref>), and be the least emotionally reactive (<xref ref-type="bibr" rid="ref46">Moreira et al., 2022b</xref>).</p>
</sec>
<sec id="sec4">
<title>1.3. Integrated temperament-character networks</title>
<p>An important prediction of Cloninger&#x2019;s personality model is that through principles of equifinality and multifinality, it is theoretically plausible for a person to have any pairing of temperament profile and character profile. While temperament does constrain character development, a person&#x2019;s temperament profile does not fully determine character development due to the influence of social learning and the stochastic effects of experience (<xref ref-type="bibr" rid="ref14">Cloninger et al., 1997</xref>), meaning there is no one-to-one correspondence between temperament and character profiles. The occurrence of all combinations of temperament and character profiles is well supported (<xref ref-type="bibr" rid="ref9">Cloninger, 2004</xref>; <xref ref-type="bibr" rid="ref23">Garcia et al., 2019</xref>; <xref ref-type="bibr" rid="ref47">Moreira et al., 2022c</xref>,<xref ref-type="bibr" rid="ref55">d</xref>), although the likelihood of each combination differs on average. For example, in a sample of adults from the U.S.A, individuals with an explosive temperament profile were most likely to have an apathetic (44%) or disorganized character profile (35%), although 7% had the healthiest creative character. In contrast, people with a reliable temperament profile were most likely to have a creative (38%) or organized character profile (21%), although 6% had the least healthy apathetic character (<xref ref-type="bibr" rid="ref14">Cloninger et al., 1997</xref>).</p>
<p>Recently, behavioral-genetic studies found that people can be classified into three nearly disjoint networks of temperament and character profiles, each strongly correlated with distinct sets of genes, <italic>which account for these patterns of associations between temperament profiles and character profiles</italic> (<xref ref-type="bibr" rid="ref73">Zwir et al., 2021</xref>). Each integrated temperament-character network most prominently expresses the prototypical features of one the three major system of human learning and memory that evolved sequentially across human evolution: associative conditioning, intentionality, and self-awareness (<xref ref-type="bibr" rid="ref74">Zwir et al., 2022</xref>; <xref ref-type="bibr" rid="ref21">Garcia et al., 2023</xref>).</p>
<p>People in the emotional-unreliable network, who prominently express the system for associative conditioning, typically have a temperament profile featuring high novelty seeking and/or high harm avoidance and a character profile featuring low self-directedness and cooperativeness. Consequently, such individuals are expected to be emotionally reactive, driven by fear, desire and habits, and are generally unhealthy and susceptible to magical thinking and unrealistic social messaging (<xref ref-type="bibr" rid="ref21">Garcia et al., 2023</xref>; <xref ref-type="bibr" rid="ref01">Zwir et al., 2023</xref>). Consistent with this, studies classifying participants into the three integrated temperament-character networks have found those in the emotional-unreliable network have lower than average engagement in school (<xref ref-type="bibr" rid="ref50">Moreira et al., 2021b</xref>), a &#x2018;dark&#x2019; sense of humor featuring high sarcasm and cynicism comic styles (<xref ref-type="bibr" rid="ref45">Moreira et al., 2022a</xref>), higher than average psychological reactance (<xref ref-type="bibr" rid="ref46">Moreira et al., 2022b</xref>), elevated negative affect and lower life satisfaction (<xref ref-type="bibr" rid="ref48">Moreira et al., 2023a</xref>), and a higher probability of ill-being (<xref ref-type="bibr" rid="ref73">Zwir et al., 2021</xref>).</p>
<p>People in the organized-reliable network, who most prominently express the system for intentionality, are more likely to have a reliable temperament with high persistence and are distinguished by an organized character profile. Given these psychobiological features, these people are tolerant and helpful and have a tendency to be capable of resourceful productivity, but are also conventional, materialistic and primarily concerned with their own interests or those of close friends/associates (<xref ref-type="bibr" rid="ref21">Garcia et al., 2023</xref>). Such features are typical of successful people in Western societies (<xref ref-type="bibr" rid="ref11">Cloninger, 2013</xref>).</p>
<p>Finally, people in the creative-reliable network, who most prominently express the most recently evolving human system of human learning and memory &#x2013; that of self-awareness &#x2013; have a reliable temperament combined with a creative character profile. These people are expected to be capable of resourceful productivity and helpful cooperation like those in the organized-reliable network, but also to be more intuitive, meditative and creative. Research has shown that these individuals experience the highest levels of positive affect and wellbeing (<xref ref-type="bibr" rid="ref73">Zwir et al., 2021</xref>; <xref ref-type="bibr" rid="ref22">Garcia et al., 2022</xref>; <xref ref-type="bibr" rid="ref48">Moreira et al., 2023a</xref>), are the most virtuous (<xref ref-type="bibr" rid="ref47">Moreira et al., 2022c</xref>), have the lightest sense of humor (including styles of humor that aim at the good; <xref ref-type="bibr" rid="ref45">Moreira et al., 2022a</xref>), and have the healthiest subjective experiences of their environments (e.g., engagement with school; <xref ref-type="bibr" rid="ref50">Moreira et al., 2021b</xref>).</p>
</sec>
<sec id="sec5">
<title>1.4. Person-centered approach in psycholexical models</title>
<p>In the last years, there has been a growing interest by person-centered approaches to personality, from the psychobiological model to the psycholexical models. Results from studies aiming at identifying personality profiles in the psycholexical models of personality have been inconsistent. The HEXACO and the Five-Factor models are the most representatives of the psycholexical models of personality. Based on the neuropharmacological evidence that dopamine is associated with exploration and incentive-related action, and serotonin with satiety and constraint, authors such as Hirsh, DeYoung and Peterson suggested that, at broadest level of description, variation in human personality reflects engagement and restraint of behavior, organized in terms of two metatraits: Plasticity (reflecting the shared variance between Extraversion and Openness/Intellect), and the metatrait of Stability (reflecting the shared variance among Neuroticism, Agreeableness, and Conscientiousness). The Plasticity metatrait was theorized to relate to individual differences in the functioning of the dopamine system while the Stability metatrait was theorized to relate to individual differences of the serotonin system (<xref ref-type="bibr" rid="ref30">Hirsh et al., 2009</xref>). <xref ref-type="bibr" rid="ref19">Espinoza et al. (2020)</xref>, using Latent Profiles Analyses, found that a 5 profiles solution fit their large data well: Profile 1: Achievement-oriented agentic (self-focused achievement orientation); Profile 2 Ego-agentic agentic (agentic orientation focusing on self within a social context); Profile 3: Insecure (high emotionality interfering with task accomplishment and social relationships); Profile 4: Communal (communal rather than task-orientation), and Profile 5: Socially Adjusted (healthy balance of agentic and communal concerns, and emotionally and socially adjusted) (<xref ref-type="bibr" rid="ref19">Espinoza et al., 2020</xref>). A recent meta-analysis conducted by Yin, Lee, Sheldon, Li and Zhao analysed 34 empirical studies using Big Five model and found that there were four possible personality profile solutions, with the three-profile (Resilient, Undercontrolled and Overcontrolled) and four-profile (Resilient, Undercontroller. Average and Undercontroller) solutions being the more predominant (<xref ref-type="bibr" rid="ref69">Yin et al., 2021</xref>). The nature of the psycholexical and the psychobiological models is so markedly different that the comparison and discussion of the meaning of the profiles found by the different models would be extremely extensive and clearly fills out the scope of this work.</p>
<p>Although the psycholexical approaches have varied in suggesting from two to five as the number of significant multi-dimensional profiles in the general population, sociological studies have consistently identified three prototypic profiles that are described as traditional, materialists (moderns), and post-materialists (cultural creatives). The most thorough empirical data is available in over 100 countries in the World Values Survey, which represents 90% of the world population (<xref ref-type="bibr" rid="ref31">Inglehart, 2018</xref>). The characteristics of people in these prototypic configurations correspond closely to those distinguished by their temperament and character configurations: emotional-unregulated people are traditionals whose values depend on authority-dependent conventions and habits), (organized-reliable people are materialists with secular-materialistic goals and egocentric values), and creative-reliable people are cultural creatives with prosocial goals and self-transcendent values) (<xref ref-type="bibr" rid="ref17">Cloninger and Zwir, 2022</xref>; <xref ref-type="bibr" rid="ref21">Garcia et al., 2023</xref>). Whether based on cognition, personality, or values, there are consistently three major prototypical groups of people in the general human population who are distinguished by specific patterns of learning and memory, temperament and character, and goals and values.</p>
</sec>
<sec id="sec6">
<title>1.5. The present study</title>
<p>As reviewed, current evidence suggests that a complete understanding of human functioning requires consideration of the multi-trait temperament and/or character profiles that describe each person as a whole. Consequently, any researchers and practitioners wanting to describe and understand the personality features of individuals relative to the general population need to consider differences in personality configurations, and not only individual dimensions. Toward this goal, it is essential to have information about the prevalence of different personality profiles and networks within a reference population. As far as we are aware, no study has specifically sought to do this, especially in terms of the recently validated integrated temperament-character networks from the TCI. Moreover, the goal of describing differences (and similarities) between demographically defined groups (e.g., age, gender, education level), including in terms of personality dimensions, is an enduring topic in psychological research that remains relevant for guiding solutions to social issues. However, the new and emerging literature on integrated temperament-character networks has not yet provided a comprehensive description of their distribution across demographic groups.</p>
<p>To address these gaps in knowledge, building on recently published normative data for the European Portuguese TCI-R (<xref ref-type="bibr" rid="ref49">Moreira et al., 2023b</xref>), the principle aim of the current study was to describe the prevalence of (a) temperament profiles, (b) character profiles, and (c) integrated temperament-character networks within a large representative sample the Portuguese adult population, including a test of the distributions of these higher-order traits as a function of gender, age cohort, and education level.</p>
</sec>
</sec>
<sec id="sec7">
<title>2. Materials and methods</title>
<sec id="sec8">
<title>2.1. Participants</title>
<p>The participants for this study were the same adults used to estimate normative values for individual temperament and character dimensions for the general continental Portuguese population (<xref ref-type="bibr" rid="ref49">Moreira et al., 2023b</xref>). The sample comprised 2,443 adults obtained from the Northern, Central and Southern districts of Portugal using a stratified sampling strategy. We used the most recent population census available at the time to determine strata based on geographical location and gender, set a target sample size for each stratum based on its proportion in the general population, and then sampled each stratum using a chain-referral strategy. Twelve participants were excluded for incorrectly responding to one or more of five validity check items incorporated in the TCI-R. Sample characteristics are presented in <xref rid="tab1" ref-type="table">Table 1</xref>. The full distribution of the sample according to age cohort, gender, and education level are shown in <xref rid="tab2" ref-type="table">Table 2</xref>.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Composition of the study sample compared to the continental Portuguese population (2011 census).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" valign="middle">Portuguese population<break/>(<italic>N</italic>&#x2009;=&#x2009;10,562,178)</th>
<th align="center" valign="middle">Sample<break/>(<italic>n</italic>&#x2009;=&#x2009;2,443)</th>
</tr>
</thead>
<tbody>
<tr>
<td/>
<td align="center" valign="top">% of population</td>
<td align="center" valign="top">% of sample</td>
</tr>
<tr>
<td align="left" valign="top">Male vs. female</td>
<td align="center" valign="top">47.7 vs. 52.2%</td>
<td align="center" valign="top">47.4 vs. 52.5%</td>
</tr>
<tr>
<td align="left" valign="top" colspan="3">Age cohort</td>
</tr>
<tr>
<td align="left" valign="top">15&#x2013;19&#x002A;</td>
<td align="center" valign="top">5.4</td>
<td align="center" valign="top">8.1</td>
</tr>
<tr>
<td align="left" valign="top">20&#x2013;29</td>
<td align="center" valign="top">11.7</td>
<td align="center" valign="top">16.6</td>
</tr>
<tr>
<td align="left" valign="top">30&#x2013;39</td>
<td align="center" valign="top">15.1</td>
<td align="center" valign="top">16.4</td>
</tr>
<tr>
<td align="left" valign="top">40&#x2013;49</td>
<td align="center" valign="top">14.6</td>
<td align="center" valign="top">16.0</td>
</tr>
<tr>
<td align="left" valign="top">50&#x2013;59</td>
<td align="center" valign="top">13.2</td>
<td align="center" valign="top">14.7</td>
</tr>
<tr>
<td align="left" valign="top">60&#x2013;69</td>
<td align="center" valign="top">11.2</td>
<td align="center" valign="top">14.2</td>
</tr>
<tr>
<td align="left" valign="top">70+</td>
<td align="center" valign="top">13.8</td>
<td align="center" valign="top">14.0</td>
</tr>
<tr>
<td align="left" valign="top" colspan="3">Region</td>
</tr>
<tr>
<td align="left" valign="top">North</td>
<td align="center" valign="top">22.7</td>
<td align="center" valign="top">21.7</td>
</tr>
<tr>
<td align="left" valign="top">Metropolitan Porto</td>
<td align="center" valign="top">12.2</td>
<td align="center" valign="top">15.4</td>
</tr>
<tr>
<td align="left" valign="top">Center</td>
<td align="center" valign="top">22.0</td>
<td align="center" valign="top">29.7</td>
</tr>
<tr>
<td align="left" valign="top">Metropolitan Lisbon</td>
<td align="center" valign="top">26.7</td>
<td align="center" valign="top">22.2</td>
</tr>
<tr>
<td align="left" valign="top">South (Alentejo + Algarve)</td>
<td align="center" valign="top">11.4</td>
<td align="center" valign="top">11.1</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>&#x002A;The present study recruited individuals aged 17&#x2009;years +, and thus does not fully cover the 15&#x2013;19 age range from the 2011 census.</p>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>Distribution of normative Portuguese sample as a function of age cohort, gender, and education level.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th rowspan="2"/>
<th align="center" valign="middle" colspan="4">Frequency (%)</th>
<th align="center" valign="middle" rowspan="2">Row total</th>
</tr>
<tr>
<th align="center" valign="middle">Primary</th>
<th align="center" valign="middle">Lower secondary</th>
<th align="center" valign="middle">Upper secondary</th>
<th align="center" valign="middle">Tertiary</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">17&#x2013;19</td>
<td/>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">0 (0)</td>
<td align="center" valign="top">21 (20)</td>
<td align="center" valign="top">83 (79)</td>
<td align="center" valign="top">1 (1)</td>
<td align="center" valign="top">105</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">0 (0)</td>
<td align="center" valign="top">43 (47)</td>
<td align="center" valign="top">49 (53)</td>
<td align="center" valign="top">0 (0)</td>
<td align="center" valign="top">92</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6">20&#x2013;29</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">0 (0)</td>
<td align="center" valign="top">32 (15)</td>
<td align="center" valign="top">103 (50)</td>
<td align="center" valign="top">72 (35)</td>
<td align="center" valign="top">207</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">0 (0)</td>
<td align="center" valign="top">52 (26)</td>
<td align="center" valign="top">98 (50)</td>
<td align="center" valign="top">47 (24)</td>
<td align="center" valign="top">197</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6">30&#x2013;39</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">3 (1)</td>
<td align="center" valign="top">40 (19)</td>
<td align="center" valign="top">53 (26)</td>
<td align="center" valign="top">110 (53)</td>
<td align="center" valign="top">206</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">0 (0)</td>
<td align="center" valign="top">30 (16)</td>
<td align="center" valign="top">77 (40)</td>
<td align="center" valign="top">86 (45)</td>
<td align="center" valign="top">193</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6">40&#x2013;49</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">18 (9)</td>
<td align="center" valign="top">53 (25)</td>
<td align="center" valign="top">61 (29)</td>
<td align="center" valign="top">77 (37)</td>
<td align="center" valign="top">209</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">11 (6)</td>
<td align="center" valign="top">71 (40)</td>
<td align="center" valign="top">49 (28)</td>
<td align="center" valign="top">46 (26)</td>
<td align="center" valign="top">177</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6">50&#x2013;59</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">56 (29)</td>
<td align="center" valign="top">52 (27)</td>
<td align="center" valign="top">38 (20)</td>
<td align="center" valign="top">46 (24)</td>
<td align="center" valign="top">192</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">38 (23)</td>
<td align="center" valign="top">62 (38)</td>
<td align="center" valign="top">41 (25)</td>
<td align="center" valign="top">24 (15)</td>
<td align="center" valign="top">165</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6">60&#x2013;69</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">90 (51)</td>
<td align="center" valign="top">39 (22)</td>
<td align="center" valign="top">17 (10)</td>
<td align="center" valign="top">32 (18)</td>
<td align="center" valign="top">178</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">69 (42)</td>
<td align="center" valign="top">48 (29)</td>
<td align="center" valign="top">16 (10)</td>
<td align="center" valign="top">32 (19)</td>
<td align="center" valign="top">165</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6">70+</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">129 (75)</td>
<td align="center" valign="top">19 (11)</td>
<td align="center" valign="top">2 (1)</td>
<td align="center" valign="top">22 (13)</td>
<td align="center" valign="top">172</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">114 (71)</td>
<td align="center" valign="top">34 (21)</td>
<td align="center" valign="top">5 (3)</td>
<td align="center" valign="top">7 (4)</td>
<td align="center" valign="top">160</td>
</tr>
<tr>
<td align="left" valign="top">Column total</td>
<td align="center" valign="top">528</td>
<td align="center" valign="top">596</td>
<td align="center" valign="top">692</td>
<td align="center" valign="top">602</td>
<td/>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec9">
<title>2.2. Measures</title>
<p>Participants completed the 240-item European Portuguese version of the TCI-R (<xref ref-type="bibr" rid="ref38">Moreira et al., 2017</xref>), which has seven scales for novelty seeking (35 items), harm avoidance (33 items), reward dependence (30 items), persistence (35 items), self-directedness (40 items), cooperativeness (36 items), and self-transcendence (26 items). All TCI-R items are scored on a 5-point Likert scale from 1 (definitely false) to 5 (definitely true). A psychometric evaluation of the European Portuguese TCI-R dimensions using the same representative sample (<xref ref-type="bibr" rid="ref49">Moreira et al., 2023b</xref>) showed the seven dimensions had excellent internal consistency reliability (McDonald&#x2019;s omega range 0.80&#x2013;0.90).</p>
<p>Participants also responded to items assessing socio-demographic characteristics. Participants reported their age in years and were grouped according to seven age categories. Gender was coded as categorical variable (male vs. female). Finally, from a series of 10 options, participants recorded their highest level of educational attainment. These options were grouped to form four higher-order categories reflecting primary education (maximum attainment of 4th grade or lower), lower secondary education (maximum attainment of 6th grade, 9th grade, or basic vocational training), upper secondary education (maximum attainment of 12th grade), and tertiary education (maximum attainment of degree or post-graduate degree, including Ph.D.).</p>
</sec>
<sec id="sec10">
<title>2.3. Profile and network formation</title>
<p>To form temperament profiles, the subjects were divided into groups reflecting those above and below the median for each of the four temperament dimensions. Participants were then grouped according to the 16 possible combinations (e.g., nhrp and NHRP). We label these temperament profiles according to the 3-dimensional profiles shown in <xref rid="fig1" ref-type="fig">Figure 1</xref>, but differentiating between profiles with high persistence vs. low persistence (e.g., explosive temperament with low persistence).</p>
<p>To form the character profiles, the subjects were divided into groups reflecting those above and below the median for each of the three character dimensions, and then grouped according to the eight possible combinations (e.g., sct and SCT). We label these character profiles according to the 3-dimensional profiles shown in <xref rid="fig2" ref-type="fig">Figure 2</xref>.</p>
<p>Finally, to represent the three integrated temperament-character networks we grouped participants with character profiles featuring low self-directedness (emotional-unreliable network); with character profiles featuring high self-directedness but with low cooperativeness and/or self-transcendence (organized-reliable network); and with a character profile featuring high levels of all three character traits (creative-reliable). Several studies (e.g., <xref ref-type="bibr" rid="ref50">Moreira et al., 2021b</xref>, <xref ref-type="bibr" rid="ref45">2022a</xref>,<xref ref-type="bibr" rid="ref45">b</xref>, <xref ref-type="bibr" rid="ref48">2023a</xref>) have confirmed that these three groupings of character profiles are a valid approximation of the three integrated temperament-character networks identified in behavioral-genetic studies with robust machine-learning algorithms (<xref ref-type="bibr" rid="ref73">Zwir et al., 2021</xref>) and therefore suitable at capturing the complex patterns of associations between temperament profiles and character profiles that occur in the general population. Confirming this, a chi-squared test indicated that the distribution of temperament profiles across the derived integrated temperament-character networks differed significantly to what would be expected by chance, <italic>&#x03C7;</italic><sup>2</sup> (30)&#x2009;=&#x2009;537.6, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. The pattern of standardized residuals for this association aligned with the networks presented by <xref ref-type="bibr" rid="ref73">Zwir et al. (2021)</xref> and hence validated our method for forming the integrated temperament-character networks (see <xref rid="fig3" ref-type="fig">Figure 3</xref>).</p>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>Heat map depicting the association between phenotypic networks and temperament profiles. Colors represent standardized residuals. &#x002A;z&#x2009;&#x003E;&#x2009;|1.96|. Panel <bold>(A)</bold> Heat maps of standardized residuals for association between phenotypic networks and temperament profiles in Men. Panel <bold>(B)</bold> Heat maps of standardized residuals for association between phenotypic networks and temperament profiles in Women</p>
</caption>
<graphic xlink:href="fpsyg-14-1193441-g003.tif"/>
</fig>
</sec>
<sec id="sec11">
<title>2.4. Statistical analysis</title>
<p>All analyses were performed using the statistical software R (<xref ref-type="bibr" rid="ref63">R Core Team, 2021</xref>). First, we described the prevalence of temperament profiles, character profiles, and integrated temperament-character networks in our representative sample.</p>
<p>Next, we explored how gender, age cohort and education level were associated with the personality profiles and networks. For this, we used contingency tables and the chi-squared (<italic>&#x03C7;</italic><sup>2</sup>) test. The chi-squared analysis tests whether the frequencies observed in a sample differ from the frequencies that would be expected from a baseline model. Significant chi-squared tests were explored further by examining standardized residuals. Standardized residuals are z-scores, and therefore standardized residuals &#x003E; |1.96| represent significance at <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05 (<xref ref-type="bibr" rid="ref20">Field, 2012</xref>).</p>
<p>Given our results, we explored how integrated temperament-character networks differ as a function of (a) gender and age cohort, and (b) gender and education level. We tested these interaction effects by performing a log-linear analysis. This included three categorical variables (age cohort or education level, gender, and integrated temperament-character networks) and the full set of interactions between them. This process involves first testing a saturated model with all interaction terms, and then a second model removing the three-way interaction (<xref ref-type="bibr" rid="ref20">Field, 2012</xref>). A significant change in the likelihood ratio statistic indicates the interaction term is statistically important. When this three-way interaction was significant, we performed additional chi-squared tests on age cohort and integrated temperament-character networks for male and female subjects independently.</p>
</sec>
</sec>
<sec id="sec12" sec-type="results">
<title>3. Results</title>
<sec id="sec13">
<title>3.1. Prevalence of personality profiles in the full sample</title>
<p>Our first aim was to describe the prevalence of temperament profiles, character profiles and integrated temperament-character networks in our normative Portuguese sample (see <xref rid="tab3" ref-type="table">Tables 3</xref>, <xref rid="tab7" ref-type="table">7</xref>). The distribution of temperament profiles within the sample was significantly different to what would be expected by chance, <italic>&#x03C7;</italic><sup>2</sup> (15)&#x2009;=&#x2009;442.7, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. Standardized residuals indicated that the passionate profile with high persistence (12.4% of the sample), methodical profile with low persistence (10.6%), explosive profile with low persistence (8.8%), cautious profile with high persistence (7.5%), and reliable profile with high persistence (7.4%) were more typical (significant types, <italic>z</italic>&#x2009;&#x003E;&#x2009;1.96) in the sample. The distribution of character profiles within the sample was also significantly different to what would be expected by chance, &#x03C7;<sup>2</sup> (7)&#x2009;=&#x2009;486.9, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. Standardized residuals indicated that the apathetic (15.7%), disorganized (18.1%), organized (16.7%) and creative (20.4%) character profiles were more typical in the sample. For the integrated temperament-character networks, we performed a &#x03C7;<sup>2</sup> test with the expected frequencies set to reflect the proportion of character profiles included in the network (emotional-unreliable&#x2009;=&#x2009;50%; organized-reliable&#x2009;=&#x2009;37.5%; creative-reliable&#x2009;=&#x2009;12.5%). The analysis indicated a significant departure from this base model, <italic>&#x03C7;</italic><sup>2</sup> (2)&#x2009;=&#x2009;156.4, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. Standardized residuals indicated that this significant result was driven by an overrepresentation of the creative-reliable network and an underrepresentation of the organized-reliable network (see <xref rid="tab4" ref-type="table">Table 4</xref>).</p>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption>
<p>Proportions of different character profiles according to temperament profile.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="center" valign="middle" rowspan="2">Temperament Profile</th>
<th align="center" valign="middle" colspan="8">Character Profiles in each temperament profile (%)</th>
<th align="center" valign="middle" rowspan="2">Row totals</th>
</tr>
<tr>
<th align="center" valign="middle">Sct &#x201C;Apathetic&#x201D;</th>
<th align="center" valign="middle">scT &#x201C;Disorganized&#x201D;</th>
<th align="center" valign="middle">sCt &#x201C;Dependent&#x201D;</th>
<th align="center" valign="middle">sCT &#x201C;Moody&#x201D;</th>
<th align="center" valign="middle">SCt &#x201C;Bossy&#x201D;</th>
<th align="center" valign="middle">ScT &#x201C;Fanatical&#x201D;</th>
<th align="center" valign="middle">SCt &#x201C;Organized&#x201D;</th>
<th align="center" valign="middle">SCT &#x201C;Creative&#x201D;</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">NHrp &#x201C;Explosive&#x201D;</td>
<td align="center" valign="middle">43</td>
<td align="center" valign="middle">30</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">NHrP</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">33</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">Nhrp &#x201C;Adventurous&#x201D;</td>
<td align="center" valign="middle">27</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">21</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">NhrP</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">17</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">NHRp &#x201C;Sensitive&#x201D;</td>
<td align="center" valign="middle">19</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">19</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">NHRP</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">17</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">20</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">NhRp &#x201C;Passionate&#x201D;</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">23</td>
<td align="center" valign="middle">23</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">NhRP</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">20</td>
<td align="center" valign="middle">42</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nHrp &#x201C;Methodical&#x201D;</td>
<td align="center" valign="middle">34</td>
<td align="center" valign="middle">21</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nHrP</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">28</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nHRp &#x201C;Cautious&#x201D;</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">17</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">23</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nHRP</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">19</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nhrp &#x201C;Independent&#x201D;</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">32</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nhrP</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">23</td>
<td align="center" valign="middle">20</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nhRp &#x201C;Reliable&#x201D;</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">56</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">100</td>
</tr>
<tr>
<td align="left" valign="middle">nhRP</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">49</td>
<td align="center" valign="middle">100</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Values in bold and paired with an asterisk reflect z&#x2009;&#x003E;&#x2009;1.96. Values paired with <sup>&#x2020;</sup> reflect <italic>z</italic>&#x2009;&#x003E;&#x2009;&#x2212;1.96.</p>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="tab4">
<label>Table 4</label>
<caption>
<p>Distribution of temperament profiles, character profiles and temperament-character networks by gender.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th rowspan="2"/>
<th align="center" valign="middle" rowspan="2">Full sample</th>
<th align="center" valign="middle" colspan="2">Frequency (%)</th>
</tr>
<tr>
<th align="center" valign="middle">&#x2642;</th>
<th align="center" valign="middle">&#x2640;</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" colspan="4">Temperament profile</td>
</tr>
<tr>
<td align="left" valign="middle">NHrp &#x201C;Explosive&#x201D;</td>
<td align="center" valign="middle">216 (8.8)</td>
<td align="center" valign="middle">99 (8.5)</td>
<td align="center" valign="middle">117 (9.1)</td>
</tr>
<tr>
<td align="left" valign="middle">NHrP</td>
<td align="center" valign="middle">57 (2.3)</td>
<td align="center" valign="middle">24 (2.1)</td>
<td align="center" valign="middle">33 (2.6)</td>
</tr>
<tr>
<td align="left" valign="middle">Nhrp &#x201C;Adventurous&#x201D;</td>
<td align="center" valign="middle">147 (6.0)</td>
<td align="center" valign="middle">
<bold>100 (8.6)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">47 (3.7)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">NhrP</td>
<td align="center" valign="middle">156 (6.4)</td>
<td align="center" valign="middle">
<bold>102 (8.8)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">54 (4.2)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">NHRp &#x201C;Sensitive&#x201D;</td>
<td align="center" valign="middle">153 (6.3)</td>
<td align="center" valign="middle">46 (4.0)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>107 (8.3)&#x002A;</bold>
</td>
</tr>
<tr>
<td align="left" valign="middle">NHRP</td>
<td align="center" valign="middle">122 (5.0)</td>
<td align="center" valign="middle">32 (2.8)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>89 (6.9)&#x002A;</bold>
</td>
</tr>
<tr>
<td align="left" valign="middle">NhRp &#x201C;Passionate&#x201D;</td>
<td align="center" valign="middle">128 (5.2)</td>
<td align="center" valign="middle">57 (4.9)</td>
<td align="center" valign="middle">71 (5.5)</td>
</tr>
<tr>
<td align="left" valign="middle">NhRP</td>
<td align="center" valign="middle">303 (12.4)</td>
<td align="center" valign="middle">134 (11.6)</td>
<td align="center" valign="middle">169 (13.2)</td>
</tr>
<tr>
<td align="left" valign="middle">nHrp &#x201C;Methodical&#x201D;</td>
<td align="center" valign="middle">258 (10.6)</td>
<td align="center" valign="middle">122 (10.5)</td>
<td align="center" valign="middle">136 (10.6)</td>
</tr>
<tr>
<td align="left" valign="middle">nHrP</td>
<td align="center" valign="middle">134 (5.5)</td>
<td align="center" valign="middle">57 (4.9)</td>
<td align="center" valign="middle">77 (6.0)</td>
</tr>
<tr>
<td align="left" valign="middle">nHRp &#x201C;Cautious&#x201D;</td>
<td align="center" valign="middle">149 (6.1)</td>
<td align="center" valign="middle">49 (4.2)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>100 (7.8)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nHRP</td>
<td align="center" valign="middle">182 (7.5)</td>
<td align="center" valign="middle">65 (5.6)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>117 (9.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nhrp &#x201C;Independent&#x201D;</td>
<td align="center" valign="middle">68 (2.8)</td>
<td align="center" valign="middle">
<bold>46 (4.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">22 (1.7)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nhrP</td>
<td align="center" valign="middle">133 (5.4)</td>
<td align="center" valign="middle">
<bold>91 (7.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">42 (3.3)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nhRp &#x201C;Reliable&#x201D;</td>
<td align="center" valign="middle">55 (2.3)</td>
<td align="center" valign="middle">32 (2.8)</td>
<td align="center" valign="middle">23 (1.8)</td>
</tr>
<tr>
<td align="left" valign="middle">nhRP</td>
<td align="center" valign="middle">181 (7.4)</td>
<td align="center" valign="middle">102 (8.8)</td>
<td align="center" valign="middle">79 (6.2)</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="4">Character profile</td>
</tr>
<tr>
<td align="left" valign="middle">sct &#x201C;Apathetic&#x201D;</td>
<td align="center" valign="middle">384 (15.7)</td>
<td align="center" valign="middle">
<bold>220 (19.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">164 (12.8)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">scT &#x201C;Disorganized&#x201D;</td>
<td align="center" valign="middle">441 (18.1)</td>
<td align="center" valign="middle">217 (18.7)</td>
<td align="center" valign="middle">223 (17.4)</td>
</tr>
<tr>
<td align="left" valign="middle">sCt &#x201C;Dependent&#x201D;</td>
<td align="center" valign="middle">134 (5.5)</td>
<td align="center" valign="middle">56 (4.8)</td>
<td align="center" valign="middle">78 (6.1)</td>
</tr>
<tr>
<td align="left" valign="middle">sCT &#x201C;Moody&#x201D;</td>
<td align="center" valign="middle">247 (10.1)</td>
<td align="center" valign="middle">73 (6.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>174 (13.6)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">Sct &#x201C;Bossy&#x201D;</td>
<td align="center" valign="middle">211 (8.6)</td>
<td align="center" valign="middle">
<bold>126 (10.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">85 (6.6)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">ScT &#x201C;Fanatical&#x201D;</td>
<td align="center" valign="middle">119 (4.9)</td>
<td align="center" valign="middle">62 (5.3)</td>
<td align="center" valign="middle">57 (4.4)</td>
</tr>
<tr>
<td align="left" valign="middle">SCt &#x201C;Organized&#x201D;</td>
<td align="center" valign="middle">408 (16.7)</td>
<td align="center" valign="middle">203 (17.5)</td>
<td align="center" valign="middle">205 (16.0)</td>
</tr>
<tr>
<td align="left" valign="middle">SCT &#x201C;Creative&#x201D;</td>
<td align="center" valign="middle">498 (20.4)</td>
<td align="center" valign="middle">201 (17.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>297 (23.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle" colspan="4">Temperament-Character network</td>
</tr>
<tr>
<td align="left" valign="middle">Emotional-Unreliable</td>
<td align="center" valign="middle">1,206 (49.4)</td>
<td align="center" valign="middle">566 (48.8)</td>
<td align="center" valign="middle">639 (49.8)</td>
</tr>
<tr>
<td align="left" valign="middle">Organized-Reliable</td>
<td align="center" valign="middle">738 (30.2)</td>
<td align="center" valign="middle">
<bold>391 (33.7)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">347 (27.0)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">Creative-Reliable</td>
<td align="center" valign="middle">498 (20.4)</td>
<td align="center" valign="middle">201 (17.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">
<bold>297 (23.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Values in bold and paired with an asterisk reflect z&#x2009;&#x003E;&#x2009;1.96. Values paired with <sup>&#x2020;</sup> reflect <italic>z</italic>&#x2009;&#x003E;&#x2009;&#x2212;1.96.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec14">
<title>3.2. Prevalence of personality profiles as a function of gender</title>
<p>There was a significant association between gender and temperament profile, <italic>&#x03C7;</italic><sup>2</sup> (15)&#x2009;=&#x2009;154.5, p&#x2009;&#x003C;&#x2009;0.001. Based on standardized residuals, it was evident that this association was driven by a greater prevalence of independent, reliable (high persistence only), and adventurous temperament profiles in men, and a greater prevalence of cautious and sensitive temperament profiles in women. A chi-squared test also showed a significant association between gender and character profile, <italic>&#x03C7;</italic><sup>2</sup> (7)&#x2009;=&#x2009;73.65, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. Standardized residuals showed that this association was driven by a greater prevalence of apathetic and bossy profiles in men, and a greater prevalence of moody and creative profiles in women. Finally, we found a significant association between gender and integrated temperament-character networks, <italic>&#x03C7;</italic><sup>2</sup> (2)&#x2009;=&#x2009;19.20, p&#x2009;&#x003C;&#x2009;0.001. This significant effect was driven by a higher prevalence of men than expected in the organized-reliable network and a higher prevalence of women than expected in the creative-reliable network.</p>
</sec>
<sec id="sec15">
<title>3.3. Prevalence of personality profiles as a function of age cohort</title>
<p>A chi-squared test revealed a significant association between age group and temperament profile, <italic>&#x03C7;</italic><sup>2</sup> (90)&#x2009;=&#x2009;328.49, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. Standardized residuals showed temperament profiles including high novelty-seeking were prevalent in younger adults whereas temperament profiles including low novelty-seeking were prevalent in older adults (see <xref rid="tab5" ref-type="table">Table 5</xref>). It was also noteworthy that temperament profiles with high harm avoidance were typical of adults aged 70+. There was a significant association between age cohort and character profile, <italic>&#x03C7;</italic><sup>2</sup> (42)&#x2009;=&#x2009;117.9, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. From the standardized residuals, it was clear the association between age and character profile was complex. However, some patterns were discernable: (a) the apathetic profile was typical of the youngest cohort; (b) the dependent profile was typical of adults in their 20s; (c) the organized profile was typical of adults aged 30&#x2013;49; (d) the distribution of character profiles did not differ significantly from chance for adults aged 50&#x2013;69; and (e) character profiles with high self-transcendence were typical of adults aged 70+. Finally, there was a significant association between age cohort and network, &#x03C7;<sup>2</sup>(12)&#x2009;=&#x2009;58.77, p&#x2009;&#x003C;&#x2009;0.001. Based on standardized residuals, it was apparent that younger adults typically occupied the emotional-unreliable network, that middle-aged adults typically occupied the organized-reliable network, and that older adults (50+ years) typically occupied the creative-reliable.</p>
<table-wrap position="float" id="tab5">
<label>Table 5</label>
<caption>
<p>Distribution of temperament profiles, character profiles and temperament-character networks by age cohort.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th rowspan="2"/>
<th align="center" valign="top" colspan="7">Frequency (%)</th>
</tr>
<tr>
<th align="center" valign="top">17&#x2013;19</th>
<th align="center" valign="top">20&#x2013;29</th>
<th align="center" valign="top">30&#x2013;39</th>
<th align="center" valign="top">40&#x2013;49</th>
<th align="center" valign="top">50&#x2013;59</th>
<th align="center" valign="top">60&#x2013;69</th>
<th align="center" valign="top">70+</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" colspan="8">Temperament profile</td>
</tr>
<tr>
<td align="left" valign="middle">NHrp &#x201C;Explosive&#x201D;</td>
<td align="center" valign="middle">15 (7.6)</td>
<td align="center" valign="middle">32 (7.9)</td>
<td align="center" valign="middle">37 (9.2)</td>
<td align="center" valign="middle">35 (9.0)</td>
<td align="center" valign="middle">39 (10.8)</td>
<td align="center" valign="middle">25 (7.2)</td>
<td align="center" valign="middle">33 (9.7)</td>
</tr>
<tr>
<td align="left" valign="middle">NHrP</td>
<td align="center" valign="middle">5 (2.5)</td>
<td align="center" valign="middle">13 (3.2)</td>
<td align="center" valign="middle">12 (3.0)</td>
<td align="center" valign="middle">9 (2.3)</td>
<td align="center" valign="middle">4 (1.1)</td>
<td align="center" valign="middle">9 (2.6)</td>
<td align="center" valign="middle">5 (1.5)</td>
</tr>
<tr>
<td align="left" valign="middle">Nhrp &#x201C;Adventurous&#x201D;</td>
<td align="center" valign="middle">
<bold>20 (10.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">25 (6.2)</td>
<td align="center" valign="middle">21 (5.2)</td>
<td align="center" valign="middle">28 (7.2)</td>
<td align="center" valign="middle">18 (5.0)</td>
<td align="center" valign="middle">21 (6.1)</td>
<td align="center" valign="middle">14 (4.1)</td>
</tr>
<tr>
<td align="left" valign="middle">NhrP</td>
<td align="center" valign="middle">16 (8.1)</td>
<td align="center" valign="middle">29 (7.2)</td>
<td align="center" valign="middle">34 (8.5)</td>
<td align="center" valign="middle">25 (6.4)</td>
<td align="center" valign="middle">23 (6.4)</td>
<td align="center" valign="middle">18 (5.2)</td>
<td align="center" valign="middle">11 (3.2)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">NHRp &#x201C;Sensitive&#x201D;</td>
<td align="center" valign="middle">21 (10.6)<sup>&#x002A;</sup></td>
<td align="center" valign="middle">
<bold>40 (9.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">26 (6.5)</td>
<td align="center" valign="middle">25 (6.4)</td>
<td align="center" valign="middle">17 (4.7)</td>
<td align="center" valign="middle">12 (3.5)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">12 (3.5)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">NHRP</td>
<td align="center" valign="middle">12 (6.1)</td>
<td align="center" valign="middle">28 (6.9)</td>
<td align="center" valign="middle">27 (6.7)</td>
<td align="center" valign="middle">17 (4.4)</td>
<td align="center" valign="middle">15 (4.2)</td>
<td align="center" valign="middle">13 (3.7)</td>
<td align="center" valign="middle">10 (2.9)</td>
</tr>
<tr>
<td align="left" valign="middle">NhRp &#x201C;Passionate&#x201D;</td>
<td align="center" valign="middle">
<bold>18 (9.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">24 (5.9)</td>
<td align="center" valign="middle">24 (6.0)</td>
<td align="center" valign="middle">22 (5.6)</td>
<td align="center" valign="middle">16 (4.4)</td>
<td align="center" valign="middle">16 (4.6)</td>
<td align="center" valign="middle">8 (2.3)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">NhRP</td>
<td align="center" valign="middle">34 (17.2)</td>
<td align="center" valign="middle">
<bold>82 (20.2)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">
<bold>74 (18.5)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">46 (11.8)</td>
<td align="center" valign="middle">30 (8.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">27 (7.8)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">10 (2.9)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nHrp &#x201C;Methodical&#x201D;</td>
<td align="center" valign="middle">19 (9.6)</td>
<td align="center" valign="middle">21 (5.2)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">26 (6.5)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">32 (8.2)</td>
<td align="center" valign="middle">50 (13.9)</td>
<td align="center" valign="middle">
<bold>51 (14.7)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">
<bold>59 (17.3)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nHrP</td>
<td align="center" valign="middle">8 (4.0)</td>
<td align="center" valign="middle">13 (3.2)</td>
<td align="center" valign="middle">14 (3.5)</td>
<td align="center" valign="middle">21 (5.4)</td>
<td align="center" valign="middle">25 (6.9)</td>
<td align="center" valign="middle">19 (5.5)</td>
<td align="center" valign="middle">
<bold>34 (10.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nHRp &#x201C;Cautious&#x201D;</td>
<td align="center" valign="middle">5 (2.5)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">14 (3.5)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">19 (4.7)</td>
<td align="center" valign="middle">16 (4.1)</td>
<td align="center" valign="middle">23 (6.4)</td>
<td align="center" valign="middle">
<bold>31 (8.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">
<bold>41 (12.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nHRP</td>
<td align="center" valign="middle">9 (4.5)</td>
<td align="center" valign="middle">19 (4.7)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">17 (4.2)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">31 (7.9)</td>
<td align="center" valign="middle">24 (6.7)</td>
<td align="center" valign="middle">
<bold>38 (11.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">
<bold>44 (12.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nhrp &#x201C;Independent&#x201D;</td>
<td align="center" valign="middle">4 (2.0)</td>
<td align="center" valign="middle">10 (2.5)</td>
<td align="center" valign="middle">8 (2.0)</td>
<td align="center" valign="middle">
<bold>18 (4.6)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">13 (3.6)</td>
<td align="center" valign="middle">12 (3.5)</td>
<td align="center" valign="middle">3 (0.9)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nhrP</td>
<td align="center" valign="middle">3 (1.5)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">27 (6.7)</td>
<td align="center" valign="middle">26 (6.5)</td>
<td align="center" valign="middle">22 (5.6)</td>
<td align="center" valign="middle">19 (5.3)</td>
<td align="center" valign="middle">16 (4.6)</td>
<td align="center" valign="middle">20 (5.9)</td>
</tr>
<tr>
<td align="left" valign="middle">nhRp &#x201C;Reliable&#x201D;</td>
<td align="center" valign="middle">1 (0.5)</td>
<td align="center" valign="middle">5 (1.2)</td>
<td align="center" valign="middle">5 (1.2)</td>
<td align="center" valign="middle">13 (3.3)</td>
<td align="center" valign="middle">10 (2.8)</td>
<td align="center" valign="middle">
<bold>16 (4.6)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">5 (1.5)</td>
</tr>
<tr>
<td align="left" valign="middle">nhRP</td>
<td align="center" valign="middle">8 (4.0)</td>
<td align="center" valign="middle">23(5.7)</td>
<td align="center" valign="middle">31 (7.7)</td>
<td align="center" valign="middle">30(7.7)</td>
<td align="center" valign="middle">34 (9.4)</td>
<td align="center" valign="middle">23 (6.6)</td>
<td align="center" valign="middle">32 (9.4)</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="8">Character profile</td>
</tr>
<tr>
<td align="left" valign="middle">sct &#x201C;Apathetic&#x201D;</td>
<td align="center" valign="middle">
<bold>49 (24.7)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">63 (15.6)</td>
<td align="center" valign="middle">57 (14.2)</td>
<td align="center" valign="middle">55 (14.1)</td>
<td align="center" valign="middle">65 (18.1)</td>
<td align="center" valign="middle">49 (14.1)</td>
<td align="center" valign="middle">46 (13.5)</td>
</tr>
<tr>
<td align="left" valign="middle">scT &#x201C;Disorganized&#x201D;</td>
<td align="center" valign="middle">43 (21.7)</td>
<td align="center" valign="middle">70 (17.3)</td>
<td align="center" valign="middle">66 (16.5)</td>
<td align="center" valign="middle">48 (12.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">71 (19.7)</td>
<td align="center" valign="middle">72 (20.7)</td>
<td align="center" valign="middle">71 (20.8)</td>
</tr>
<tr>
<td align="left" valign="middle">sCt &#x201C;Dependent&#x201D;</td>
<td align="center" valign="middle">14 (7.1)</td>
<td align="center" valign="middle">
<bold>32 (7.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">23 (5.7)</td>
<td align="center" valign="middle">24 (6.2)</td>
<td align="center" valign="middle">13 (3.6)</td>
<td align="center" valign="middle">15 (4.3)</td>
<td align="center" valign="middle">13 (3.8)</td>
</tr>
<tr>
<td align="left" valign="middle">sCT &#x201C;Moody&#x201D;</td>
<td align="center" valign="middle">25 (12.6)</td>
<td align="center" valign="middle">42 (10.4)</td>
<td align="center" valign="middle">31 (7.7)</td>
<td align="center" valign="middle">30 (7.7)</td>
<td align="center" valign="middle">32 (8.9)</td>
<td align="center" valign="middle">35 (10.1)</td>
<td align="center" valign="middle">
<bold>52 (15.2)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">Sct &#x201C;Bossy&#x201D;</td>
<td align="center" valign="middle">15 (7.6)</td>
<td align="center" valign="middle">39 (9.6)</td>
<td align="center" valign="middle">36 (9.0)</td>
<td align="center" valign="middle">44 (11.3)</td>
<td align="center" valign="middle">34 (9.4)</td>
<td align="center" valign="middle">27 (7.8)</td>
<td align="center" valign="middle">16 (4.7)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">ScT &#x201C;Fanatical&#x201D;</td>
<td align="center" valign="middle">8 (4.0)</td>
<td align="center" valign="middle">18 (4.4)</td>
<td align="center" valign="middle">13 (3.2)</td>
<td align="center" valign="middle">18 (4.6)</td>
<td align="center" valign="middle">19 (5.3)</td>
<td align="center" valign="middle">15 (4.3)</td>
<td align="center" valign="middle">
<bold>28 (8.2)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">SCt &#x201C;Organized&#x201D;</td>
<td align="center" valign="middle">21 (10.6)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">79 (19.5)</td>
<td align="center" valign="middle">83 (20.7)</td>
<td align="center" valign="middle">
<bold>85 (21.8)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">49 (13.6)</td>
<td align="center" valign="middle">56 (16.1)</td>
<td align="center" valign="middle">35 (10.3)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">SCT &#x201C;Creative&#x201D;</td>
<td align="center" valign="middle">23 (11.6)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">62 (15.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">92 (22.9)</td>
<td align="center" valign="middle">86 (22.1)</td>
<td align="center" valign="middle">77 (21.4)</td>
<td align="center" valign="middle">78 (22.5)</td>
<td align="center" valign="middle">80 (23.5)</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="8">Temperament-Character network</td>
</tr>
<tr>
<td align="left" valign="middle">Emotional-Unreliable</td>
<td align="center" valign="middle">
<bold>131 (66.2)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">207 (51.1)</td>
<td align="center" valign="middle">177 (44.1)</td>
<td align="center" valign="middle">157 (40.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">181 (50.3)</td>
<td align="center" valign="middle">171 (49.3)</td>
<td align="center" valign="middle">182 (53.4)</td>
</tr>
<tr>
<td align="left" valign="middle">Organized-Reliable</td>
<td align="center" valign="middle">44 (22.2)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">136 (33.6)</td>
<td align="center" valign="middle">123 (32.9)</td>
<td align="center" valign="middle">
<bold>147 (37.7)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">102 (28.3)</td>
<td align="center" valign="middle">98 (28.2)</td>
<td align="center" valign="middle">79 (23.2)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">Creative-Reliable</td>
<td align="center" valign="middle">23 (11.6)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">62 (15.3)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">92 (22.9)</td>
<td align="center" valign="middle">86 (22.1)</td>
<td align="center" valign="middle">88 (21.4)</td>
<td align="center" valign="middle">78 (22.5)</td>
<td align="center" valign="middle">80 (23.5)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Values in bold and paired with an asterisk reflect z&#x2009;&#x003E;&#x2009;1.96. Values paired with <sup>&#x2020;</sup> reflect z&#x2009;&#x003E;&#x2009;&#x2212;1.96</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec16">
<title>3.4. Associations between personality and education level</title>
<p>The analysis revealed a significant association between temperament profile and education level, &#x03C7;<sup>2</sup> (75)&#x2009;=&#x2009;257.79, p&#x2009;&#x003C;&#x2009;0.001. Standardized residuals showed that the cautious temperaments were typical of participants with 4th grade education or less (<xref rid="tab6" ref-type="table">Table 6</xref>). In contrast, the passionate temperament (high persistence only) was typical of those with the higher levels of education. There was also a significant association between character profile and education level, &#x03C7;<sup>2</sup> (35)&#x2009;=&#x2009;128.04, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001. The standardized residuals from this analysis showed that the creative and organized character profiles were typical of participants with a degree. In contrast, the apathetic character profile was typical of those with a maximum attainment of the 6th or 9th grade. The disorganized and fanatical character profiles were typical of those with a maximum attainment of the 4th grade. Finally, while not significant, adults with the lowest educational attainment were linked to the dependent and moody profiles. Finally, there was a significant association between integrated temperament-character network and education level, &#x03C7;<sup>2</sup> (10)&#x2009;=&#x2009;48.55, p&#x2009;&#x003C;&#x2009;0.001. Based on standardized residuals, it was evident that the organized-reliable and creative-reliable networks were typical of participants with a degree. While not significant at <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05, there was a trend for the emotional-unreliable network to be typical of participants with a maximum education attainment of 9th grade or less.</p>
<table-wrap position="float" id="tab6">
<label>Table 6</label>
<caption>
<p>Distribution of temperament profiles, character profiles and integrated temperament-character networks by education level.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th rowspan="2"/>
<th align="center" valign="top" colspan="4">Frequency (%)</th>
</tr>
<tr>
<th align="center" valign="top">Primary</th>
<th align="center" valign="top">Lower secondary</th>
<th align="center" valign="top">Upper secondary</th>
<th align="center" valign="top">Tertiary</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" colspan="5">Temperament profile</td>
</tr>
<tr>
<td align="left" valign="middle">NHrp &#x201C;Explosive&#x201D;</td>
<td align="center" valign="middle">49 (9.3)</td>
<td align="center" valign="middle">
<bold>69 (11.6)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">60 (8.7)</td>
<td align="center" valign="middle">32 (5.3)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">NHrP</td>
<td align="center" valign="middle">8 (1.5)</td>
<td align="center" valign="middle">15 (2.5)</td>
<td align="center" valign="middle">23 (3.3)</td>
<td align="center" valign="middle">11 (1.8)</td>
</tr>
<tr>
<td align="left" valign="middle">Nhrp &#x201C;Adventurous&#x201D;</td>
<td align="center" valign="middle">27 (5.1)</td>
<td align="center" valign="middle">38 (6.4)</td>
<td align="center" valign="middle">44 (6.3)</td>
<td align="center" valign="middle">36 (6.0)</td>
</tr>
<tr>
<td align="left" valign="middle">NhrP</td>
<td align="center" valign="middle">22 (4.2)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">33 (5.5)</td>
<td align="center" valign="middle">
<bold>59 (8.5)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">41 (6.8)</td>
</tr>
<tr>
<td align="left" valign="middle">NHRp &#x201C;Sensitive&#x201D;</td>
<td align="center" valign="middle">19 (3.6)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">37 (6.2)</td>
<td align="center" valign="middle">53 (7.6)</td>
<td align="center" valign="middle">43 (7.1)</td>
</tr>
<tr>
<td align="left" valign="middle">NHRP</td>
<td align="center" valign="middle">15 (2.8)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">29 (4.9)</td>
<td align="center" valign="middle">42 (6.1)</td>
<td align="center" valign="middle">35 (5.8)</td>
</tr>
<tr>
<td align="left" valign="middle">NhRp &#x201C;Passionate&#x201D;</td>
<td align="center" valign="middle">16 (3.0)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">27 (4.5)</td>
<td align="center" valign="middle">43 (6.2)</td>
<td align="center" valign="middle">41 (6.8)</td>
</tr>
<tr>
<td align="left" valign="middle">NhRP</td>
<td align="center" valign="middle">27 (5.1)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">60 (10.1)</td>
<td align="center" valign="middle">
<bold>107 (15.4)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">
<bold>108 (17.9)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">nHrp &#x201C;Methodical&#x201D;</td>
<td align="center" valign="middle">
<bold>94 (17.8)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">58 (9.7)</td>
<td align="center" valign="middle">56 (8.1)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">49 (8.1)</td>
</tr>
<tr>
<td align="left" valign="middle">nHrP</td>
<td align="center" valign="middle">
<bold>53 (10.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">25 (4.2)</td>
<td align="center" valign="middle">28 (4.0)</td>
<td align="center" valign="middle">26 (4.3)</td>
</tr>
<tr>
<td align="left" valign="middle">nHRp &#x201C;Cautious&#x201D;</td>
<td align="center" valign="middle">
<bold>52 (9.8)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">32 (5.4)</td>
<td align="center" valign="middle">32 (4.6)</td>
<td align="center" valign="middle">33 (5.5)</td>
</tr>
<tr>
<td align="left" valign="middle">nHRP</td>
<td align="center" valign="middle">
<bold>59 (11.2)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">53 (8.9)</td>
<td align="center" valign="middle">33 (4.8)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">36 (6.0)</td>
</tr>
<tr>
<td align="left" valign="middle">nhrp &#x201C;Independent&#x201D;</td>
<td align="center" valign="middle">10 (1.9)</td>
<td align="center" valign="middle">
<bold>27 (4.5)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">17 (2.5)</td>
<td align="center" valign="middle">14 (2.3)</td>
</tr>
<tr>
<td align="left" valign="middle">nhrP</td>
<td align="center" valign="middle">30 (5.7)</td>
<td align="center" valign="middle">34 (5.7)</td>
<td align="center" valign="middle">37 (5.3)</td>
<td align="center" valign="middle">29 (4.8)</td>
</tr>
<tr>
<td align="left" valign="middle">nhRp &#x201C;Reliable&#x201D;</td>
<td align="center" valign="middle">10 (1.9)</td>
<td align="center" valign="middle">14 (2.3)</td>
<td align="center" valign="middle">13 (1.9)</td>
<td align="center" valign="middle">17 (2.8)</td>
</tr>
<tr>
<td align="left" valign="middle">nhRP</td>
<td align="center" valign="middle">37 (7.0)</td>
<td align="center" valign="middle">45 (7.6)</td>
<td align="center" valign="middle">46 (6.6)</td>
<td align="center" valign="middle">51 (8.5)</td>
</tr>
<tr>
<td align="left" valign="middle" colspan="5">Character profile</td>
</tr>
<tr>
<td align="left" valign="middle">sct &#x201C;Apathetic&#x201D;</td>
<td align="center" valign="middle">81 (15.3)</td>
<td align="center" valign="middle">
<bold>127 (21.3)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">113 (16.3)</td>
<td align="center" valign="middle">59 (9.8)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">scT &#x201C;Disorganized&#x201D;</td>
<td align="center" valign="middle">
<bold>129 (24.4)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">108 (18.1)</td>
<td align="center" valign="middle">122 (17.6)</td>
<td align="center" valign="middle">75 (12.5)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">sCt &#x201C;Dependent&#x201D;</td>
<td align="center" valign="middle">20 (3.8)</td>
<td align="center" valign="middle">32 (5.4)</td>
<td align="center" valign="middle">40 (5.8)</td>
<td align="center" valign="middle">42 (7.0)</td>
</tr>
<tr>
<td align="left" valign="middle">sCT &#x201C;Moody&#x201D;</td>
<td align="center" valign="middle">57 (10.8)</td>
<td align="center" valign="middle">61 (10.2)</td>
<td align="center" valign="middle">66 (9.5)</td>
<td align="center" valign="middle">57 (9.5)</td>
</tr>
<tr>
<td align="left" valign="middle">Sct &#x201C;Bossy&#x201D;</td>
<td align="center" valign="middle">46 (8.7)</td>
<td align="center" valign="middle">44 (7.4)</td>
<td align="center" valign="middle">74 (10.7)</td>
<td align="center" valign="middle">46 (7.6)</td>
</tr>
<tr>
<td align="left" valign="middle">ScT &#x201C;Fanatical&#x201D;</td>
<td align="center" valign="middle">
<bold>37 (7.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">31 (5.2)</td>
<td align="center" valign="middle">25 (3.6)</td>
<td align="center" valign="middle">25 (4.2)</td>
</tr>
<tr>
<td align="left" valign="middle">SCt &#x201C;Organized&#x201D;</td>
<td align="center" valign="middle">62 (11.7)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">87 (14.6)</td>
<td align="center" valign="middle">117 (16.9)</td>
<td align="center" valign="middle">
<bold>141 (23.4)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">SCT &#x201C;Creative&#x201D;</td>
<td align="center" valign="middle">96 (18.2)<sup>&#x2020;</sup></td>
<td align="center" valign="middle">106 (17.8)</td>
<td align="center" valign="middle">136 (19.6)</td>
<td align="center" valign="middle">
<bold>157 (26.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle" colspan="5">Temperament-Character network</td>
</tr>
<tr>
<td align="left" valign="middle">Emotional-Unreliable</td>
<td align="center" valign="middle">287 (54.4)</td>
<td align="center" valign="middle">
<bold>328 (55.0)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
<td align="center" valign="middle">341 (49.2)</td>
<td align="center" valign="middle">233 (38.7)<sup>&#x2020;</sup></td>
</tr>
<tr>
<td align="left" valign="middle">Organized-Reliable</td>
<td align="center" valign="middle">145 (27.5)</td>
<td align="center" valign="middle">162 (27.2)</td>
<td align="center" valign="middle">216 (31.2)</td>
<td align="center" valign="middle">
<bold>212 (35.2)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
<tr>
<td align="left" valign="middle">Creative-Reliable</td>
<td align="center" valign="middle">96 (18.2)</td>
<td align="center" valign="middle">106 (17.8)</td>
<td align="center" valign="middle">136 (19.6)</td>
<td align="center" valign="middle">
<bold>157 (26.1)</bold><sup>
<bold>&#x002A;</bold>
</sup></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Values in bold and paired with an asterisk reflect z&#x2009;&#x003E;&#x2009;1.96. Values paired with <sup>&#x2020;</sup> reflect <italic>z</italic>&#x2009;&#x003E;&#x2009;&#x2212;1.96.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec17">
<title>3.5. Interaction effects: age cohort and education level effects as a function of gender</title>
<p>Age cohort &#x00D7; gender. The three-way log-linear analysis retained all effects, meaning the three-way age cohort &#x00D7; gender &#x00D7; integrated temperament-character network interaction was statistically significant, &#x03C7;<sup>2</sup> (12) =22.82, <italic>p</italic>&#x2009;=&#x2009;0.029. Follow-up chi-squared tests showed there was a significant association between age cohort and network for women, &#x03C7;<sup>2</sup> (12) =61.03, p&#x2009;&#x003C;&#x2009;0.001, but not for men, &#x03C7;<sup>2</sup> (12) =20.02, <italic>p</italic>&#x2009;=&#x2009;0.067 (<xref rid="fig4" ref-type="fig">Figure 4</xref>).</p>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption>
<p>Heat maps of standardized residuals for association between integrated temperament-character networks and age cohort for men and women separately. Green represents positive values (occurs more frequently than expected). Red represents negative values (occurs less frequently than expected). &#x002A;Standardized residuals &#x003E; |1.96|, correspond to <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05. Panel <bold>(A)</bold> Heat maps of standardized residuals for association between integrated temperament-charcater networks and age in Man. Panel <bold>(B)</bold> Heat maps of standardized residuals for association between integrated temperament-charcater networks and age in Women.</p>
</caption>
<graphic xlink:href="fpsyg-14-1193441-g004.tif"/>
</fig>
<p>Education level &#x00D7; gender. The three-way log-linear analysis did not retain all effects, meaning the three-way education level &#x00D7; gender &#x00D7; integrated temperament-character network interaction was not statistically significant, &#x03C7;<sup>2</sup> (6) =3.81, <italic>p</italic>&#x2009;=&#x2009;0.703 (<xref rid="fig5" ref-type="fig">Figure 5</xref>). Separate chi-squared tests showed there were significant associations between education level and network for both men, <italic>&#x03C7;</italic><sup>2</sup>(6) =20.75, <italic>p</italic>&#x2009;=&#x2009;0.002, and women, <italic>&#x03C7;</italic><sup>2</sup>(6) =24.74, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001.</p>
<fig position="float" id="fig5">
<label>Figure 5</label>
<caption>
<p>Heat maps of standardized residuals for association between integrated temperament-character networks and education level for men and women separately. Green represents positive values (occurs more frequently than expected). Red represents negative values (occurs less frequently than expected). &#x002A;Standardized residuals &#x003E; |1.96|, correspond to <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05.</p>
</caption>
<graphic xlink:href="fpsyg-14-1193441-g005.tif"/>
</fig>
</sec>
</sec>
<sec id="sec18" sec-type="discussions">
<title>4. Discussion</title>
<p>Complementing the normative values for individual temperament and character dimensions presented elsewhere (<xref ref-type="bibr" rid="ref49">Moreira et al., 2023b</xref>) the present study offers a comprehensive description of the multi-trait personality profiles and networks as they occur within the continental Portuguese population (see <xref rid="tab7" ref-type="table">Table 7</xref>). Specifically, we presented normative frequencies for temperament profiles, character profiles, and integrated temperament-character networks for the whole representative sample as well as separately for men vs. women, across multiple age cohorts ranging from youth (17&#x2013;19&#x2009;years) to old age (70+ years), and across adults with different educational attainment. We consider each of these results in turn:</p>
<table-wrap position="float" id="tab7">
<label>Table 7</label>
<caption>
<p>Full frequency table of temperament profiles, character profiles, and joint temperament-character networks.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="center" valign="middle" rowspan="3">Network</th>
<th align="center" valign="middle" rowspan="3">Character<break/>Profile</th>
<th align="center" valign="top" colspan="16">Temperament Profile</th>
<th align="center" valign="top" rowspan="3">C Total</th>
<th align="center" valign="top" rowspan="3">N Total</th>
</tr>
<tr>
<th align="center" valign="middle" colspan="2">Independent</th>
<th align="center" valign="middle" colspan="2">Reliable</th>
<th align="center" valign="middle" colspan="2">Methodical</th>
<th align="center" valign="middle" colspan="2">Cautious</th>
<th align="center" valign="middle" colspan="2">Adventurous</th>
<th align="center" valign="middle" colspan="2">Passionate</th>
<th align="center" valign="middle" colspan="2">Explosive</th>
<th align="center" valign="middle" colspan="2">Sensitive</th>
</tr>
<tr>
<th align="center" valign="middle">nhrp</th>
<th align="center" valign="middle">nhrP</th>
<th align="center" valign="middle">nhRp</th>
<th align="center" valign="middle">nhRP</th>
<th align="center" valign="middle">nHrp</th>
<th align="center" valign="middle">nHrP</th>
<th align="center" valign="middle">nHRp</th>
<th align="center" valign="middle">nHRP</th>
<th align="center" valign="middle">Nhrp</th>
<th align="center" valign="middle">NhrP</th>
<th align="center" valign="middle">NhRp</th>
<th align="center" valign="middle">NhRP</th>
<th align="center" valign="middle">NHrp</th>
<th align="center" valign="middle">NHrP</th>
<th align="center" valign="middle">NHRp</th>
<th align="center" valign="middle">NHRP</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" rowspan="4">Emo-Un.</td>
<td align="center" valign="middle">sct</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">88</td>
<td align="center" valign="middle">20</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">40</td>
<td align="center" valign="middle">23</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">92</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">29</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="bottom">384</td>
<td align="center" valign="middle" rowspan="4">1,206</td>
</tr>
<tr>
<td align="center" valign="middle">scT</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">54</td>
<td align="center" valign="middle">38</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">35</td>
<td align="center" valign="middle">36</td>
<td align="center" valign="middle">37</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">37</td>
<td align="center" valign="middle">64</td>
<td align="center" valign="middle">19</td>
<td align="center" valign="middle">28</td>
<td align="center" valign="middle">21</td>
<td align="center" valign="bottom">441</td>
</tr>
<tr>
<td align="center" valign="middle">sCt</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">26</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">17</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="bottom">134</td>
</tr>
<tr>
<td align="center" valign="middle">sCT</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">20</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">44</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">29</td>
<td align="center" valign="middle">38</td>
<td align="center" valign="bottom">247</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="3">Org-Rel.</td>
<td align="center" valign="middle">Sct</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">21</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">27</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">27</td>
<td align="center" valign="middle">19</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="bottom">211</td>
<td align="center" valign="middle" rowspan="3">738</td>
</tr>
<tr>
<td align="center" valign="middle">ScT</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="bottom">119</td>
</tr>
<tr>
<td align="center" valign="middle">SCt</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">46</td>
<td align="center" valign="middle">20</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">33</td>
<td align="center" valign="middle">17</td>
<td align="center" valign="middle">23</td>
<td align="center" valign="middle">29</td>
<td align="center" valign="middle">61</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="bottom">408</td>
</tr>
<tr>
<td align="left" valign="middle">Cre-Rel.</td>
<td align="center" valign="middle">SCT</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">27</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">88</td>
<td align="center" valign="middle">18</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">34</td>
<td align="center" valign="middle">45</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">30</td>
<td align="center" valign="middle">126</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="bottom">498</td>
<td align="center" valign="middle">498</td>
</tr>
<tr>
<td/>
<td align="center" valign="middle">T Total</td>
<td align="center" valign="middle">68</td>
<td align="center" valign="middle">133</td>
<td align="center" valign="middle">55</td>
<td align="center" valign="middle">181</td>
<td align="center" valign="middle">258</td>
<td align="center" valign="middle">134</td>
<td align="center" valign="middle">149</td>
<td align="center" valign="middle">182</td>
<td align="center" valign="middle">147</td>
<td align="center" valign="middle">156</td>
<td align="center" valign="middle">128</td>
<td align="center" valign="middle">303</td>
<td align="center" valign="middle">216</td>
<td align="center" valign="middle">57</td>
<td align="center" valign="middle">153</td>
<td align="center" valign="middle">122</td>
<td/>
<td/>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Emo-Un, Emotional-Unreliable Network; Org-Rel, Organized-Reliable Network; Cre-Rel, Creative-Reliable Network.</p>
</table-wrap-foot>
</table-wrap>
<p>A large body of research has demonstrated the nonlinear dynamics of personality development via the principals of equifinality and multifinality (<xref ref-type="bibr" rid="ref14">Cloninger et al., 1997</xref>; <xref ref-type="bibr" rid="ref9">Cloninger, 2004</xref>). All combinations of temperament and character are theoretically plausible (but not necessarily as likely), with the same character profile having different antecedent temperament profiles (equifinality) and the same temperament profile having different outcomes in terms of character coherence (multifinality). Aligning with these principals, our study showed that all but one of the 128 possible combinations of temperament profiles and character profiles emerged in the sample. Moreover, we found that certain profiles were more prevalent than others. For example, aligning with prior works (<xref ref-type="bibr" rid="ref14">Cloninger et al., 1997</xref>; <xref ref-type="bibr" rid="ref10">Cloninger, 2009</xref>), we found that individuals with an explosive temperament were far more likely to have an immature apathetic character than a mature creative character. Also consistent with past studies, we found that individuals with a reliable temperament (nhR) with high persistence were particularly predisposed to have a well-developed character.</p>
<sec id="sec19">
<title>4.1. Gender differences</title>
<p>When assessing differences between men and women in the Portuguese population we found several significant differences. This is noteworthy given that almost all differences between men and women for individual TCI traits were of a negligible effect size (<xref ref-type="bibr" rid="ref49">Moreira et al., 2023b</xref>). All temperament configurations were evident in both sexes, but we found profiles with a combination of low harm avoidance and low reward dependence were typical (more cases than expected under the base model) of the men while profiles with a combination of high harm avoidance and high reward dependence were typical of women. All character configurations were also evident in both sexes. However, the most severely immature character profile was identified as a type in men while the healthiest creative character profile was typical in women. Finally, we found that the organized-reliable network was typical of men, implying that on average, men displayed traits of being capable of resourceful productivity but more conventional, materialistic and practical, and not always fully cooperative with others. In turn, the creative-reliable phenotypic network was shown to be typical of women, implying that the average Portuguese women was more likely to be capable of resourceful productivity and helpful cooperation combined with being more intuitive, meditative and creative.</p>
</sec>
<sec id="sec20">
<title>4.2. Differences between age cohorts</title>
<p>The study revealed several differences in personality between the age cohorts. Specifically, we found that a small number of temperament profiles were typical of certain age cohorts. First, temperament profiles characterized by the combination of low novelty seeking and high harm avoidance were typical of older retirement-aged adults, as has been identified in other cross-sectional studies focused on individual traits (<xref ref-type="bibr" rid="ref68">Trouillet and Gana, 2008</xref>; <xref ref-type="bibr" rid="ref1">Calvet et al., 2016</xref>). Individuals with this combination of traits usually show behavior that is patient, quiet and serenity seeking (<xref ref-type="bibr" rid="ref5">Cloninger, 1987</xref>). Second, we found that three profiles with the shared configuration of high novelty seeking (more eager to explore new ways to do things) and low persistence (quick to abandon previously rewarded behavior) were typical of the youngest cohort. This implies that individuals in their late teens differ from other adults in that they still show signs of the developmental changes typically observed in adolescents pertaining to identity formation and emancipation from adult authority (<xref ref-type="bibr" rid="ref70">Zohar et al., 2019</xref>).</p>
<p>We also found that the most immature character profile (the apathetic character) was typical of the youngest adults while the organized profile -- which is linked to being highly self-confident, responsible, resourceful, tolerant and helpful, but also materialistic and practical rather than meditative and spiritual (<xref ref-type="bibr" rid="ref11">Cloninger, 2013</xref>) -- was typical of adults in their 40&#x2019;s. Indeed, the organized character profile was found to be an &#x2018;antitype&#x2019; of the very youngest and very oldest age cohorts, implying a nonlinear effect with age. Although not statistically significant, it was apparent that the oldest age cohort had the largest proportion of creative-reliable network (23.5%). These results are consistent with the idea that mean levels of personality traits can be shaped by socialization effects. For example, adults in their 40s are likely to be strongly invested in their careers (and more likely than younger adults to be at a stage when they are starting senior positions) and, therefore, are likely to experience strong social pressures to work hard and get along with colleagues; that is, to be self-directed and cooperative. Having this type of mature character is advantageous because it allows an individual to regulate their emotions responsibly and behave rationally, which in turn helps one to work effectively and engage in culturally-valued tasks. Our finding that Portuguese adults in their 40s typically presented an organized character profile is consistent with observed developmental trends identified in a longitudinal study of Finnish adults (<xref ref-type="bibr" rid="ref33">Josefsson et al., 2013</xref>). The fact that the oldest Portuguese adults had the highest prevalence of character profiles with high self-transcendence is also consistent with prior cross-sectional studies (<xref ref-type="bibr" rid="ref8">Cloninger, 2003</xref>). One reason for this elevated self-transcendence is that older people will start to face more death and confront their mortality, for which high self-transcendence is adaptive (<xref ref-type="bibr" rid="ref9">Cloninger, 2004</xref>).</p>
</sec>
<sec id="sec21">
<title>4.3. Differences in personality as a function of education</title>
<p>It is important to acknowledge that our data were cross-sectional, meaning that cohort effects may be critical for understanding the observed effect of age cohort. One such generational difference is maximum educational attainment, which is known to vary markedly across age groups in Portugal (owing to factors such as the dictatorship in the first half of the 20th century). Consistent with this, we observed that retirement age adults in our sample were far more likely to have a primary or lower secondary level of education compared to working-aged adults (see <xref rid="tab2" ref-type="table">Table 2</xref>).</p>
<p>When assessing personality differences as a function of education we found that the highest level of character maturity and personality coherence (including high self-transcendence alongside self-directedness and cooperativeness) was linked to a tertiary education. In turn, we found that immature character and unregulated emotional reactivity was linked to the lowest levels of educational attainment. This effect was broadly the same for men and women. As far as we are aware, no other prior study has systematically shown how TCI traits or profiles vary as a function of educational attainment. However, our findings align with those of studies using alternative personality models. This includes the observed positive correlation between years of education and lexically-derived Conscious Restraint and Openness/Intellect personality dimensions (<xref ref-type="bibr" rid="ref25">Goldberg et al., 1998</xref>). Conscious restraint reflects traits such as being self-disciplined, socially responsible, and controlled, and is thus conceptually proximal to self-directedness and the notion of intentional and rational self-regulation. In turn, Openness/Intellect captures individuals who are imaginative, innovative, perceptive, philosophical, and interested in truth and beauty, and therefore shares partial conceptual overlap with self-transcendence (as has been supported empirically; <xref ref-type="bibr" rid="ref18">De Fruyt et al., 2000</xref>).</p>
<p>The capacity to be self-directed and cooperative with others is not only strongly encouraged in education settings (<xref ref-type="bibr" rid="ref39">Moreira et al., 2010</xref>), but also highly advantageous to being successful during academic trajectories, including Higher education. Thus, norms, values and practices around higher education are all likely to exert an important influence on the development of a mature character (<xref ref-type="bibr" rid="ref2">Caspi et al., 2005</xref>). However, our results show that people with the highest level of education were not only more mature in an organized sense (self-directed and cooperative), but also in a creative self-aware sense (with the addition of high self-transcendence). Creativity refers to original, adaptive and beneficial innovation linked to a creative state of mind characterized by &#x201C;calm alertness with a flowing intuitive awareness that awakens automatic intelligences&#x201D; (p7. <xref ref-type="bibr" rid="ref12">Cloninger and Cloninger, 2013</xref>). One possibility is that personality change toward creativity can occur in the context of tertiary education because high intellectual and attentional demands leads to distinct patterns of neural activation. For example, neuroscientific studies have shown that sustained attention is associated with high activation of the prefrontal cortex, which can in turn lead to deafferentation of the parietal lobe. Such cessation of neural signaling to this part of the brain has been linked to feelings of unit with one&#x2019;s environment, which is a key feature of self-transcendence (<xref ref-type="bibr" rid="ref61">Newberg and D&#x2019;Aquili, 2000</xref>).</p>
</sec>
<sec id="sec22">
<title>4.4. Interaction effects</title>
<p>A noteworthy finding in this study was the observed age cohort-by-gender interaction effect on integrated temperament-character network. Specifically, while there was a general trend for older men to have the more integrated and coherent personalities, personality coherence appeared to be greatest in women in their 30s. Because personality coherence was highest in adults with the best educational attainments, and because middle-aged women were more likely to have a tertiary education than elderly women and late teens, it appears that age cohort had relatively little influence on personality for women. Put differently, our finding strongly implied that education level was a stronger predictor of personality coherence in women than decade of birth. This leaves the question of why the same effect was not observed for men, especially as men showed similar patterns of educational attainment across age cohorts as women.</p>
</sec>
<sec id="sec23">
<title>4.5. Limitations</title>
<p>This study has some limitations that are important to consider. Firstly, the TCI-R is a self-report instrument, meaning that some individuals may have been inclined to present themselves favorably rather than truthfully. However, the TCI-R has been validated extensively, and so we expect our results to be reproducible. Second, we note that this study considered the three self-transcendence dimensions included in the original TCI. Updates to the TCI (<xref ref-type="bibr" rid="ref17">Cloninger and Zwir, 2022</xref>) since our data collection now posit five dimensions. Thus, researchers may in the future wish to update the normative data presented here to include the new ST dimensions.</p>
</sec>
</sec>
<sec id="sec24" sec-type="conclusions">
<title>5. Conclusion</title>
<p>This study is the first to characterize a normative sample in terms of its temperament profiles, character profiles, and integrated temperament-character networks. All combinations of TCI traits are theoretically possible, although the study demonstrates that certain configurations were more prevalent among Portuguese adults than others. Moreover, we demonstrate that the prevalence of profiles and networks varied as a function of age cohort, gender, and education level. Independent of age and education, women were more likely to be capable of resourceful productivity and helpful cooperation combined with being more intuitive, meditative and creative than men. Independent of age and gender, individuals with a degree were also more likely to present these biopsychosocial features. We also found that the organized character profile (typical of leaders and successful individuals in Western cultures, linked to being highly self-confident, responsible, resourceful, tolerant and helpful, but also materialistic and practical rather than meditative and spiritual; <xref ref-type="bibr" rid="ref11">Cloninger, 2013</xref>) was most typical of adults in their 40s. Finally, the distribution of personality profiles across age differed as a function of gender: for men the oldest individuals had the most coherent personalities while high personality integration was most prevalent for women in their 30s.</p>
</sec>
<sec id="sec25" sec-type="data-availability">
<title>Data availability statement</title>
<p>The datasets presented in this article are not readily available because the data is copyrighted. Requests to access the datasets should be directed to <email>pmoreira@utad.pt</email>.</p>
</sec>
<sec id="sec26">
<title>Ethics statement</title>
<p>The studies involving human participants were reviewed and approved by CIPD. The patients/participants provided their written informed consent to participate in this study.</p>
</sec>
<sec id="sec27">
<title>Author contributions</title>
<p>PM conceptualization, project administration, resources, investigation, methodology, supervision, writing &#x2013; original draft preparation, and review and editing. RI data curation, formal analysis, software, visualization, and writing &#x2013; original draft preparation. RC conceptualization and writing &#x2013; review and editing. All authors contributed to the article and approved the submitted version.</p>
</sec>
<sec id="sec231" sec-type="funding-information">
<title>Funding</title>
<p>This work was supported by Portuguese Funds through the Portuguese Foundation for Science and Technology (FCT), under the multi-year funding awarded to CIPD [grant number UIDB/04375/2020].</p>
</sec>
<sec id="conf1" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="sec100" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</body>
<back>
<sec id="sec29" sec-type="supplementary-material">
<title>Supplementary material</title>
<p>The Supplementary material for this article can be found online at: <ext-link xlink:href="https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1193441/full#supplementary-material" ext-link-type="uri">https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1193441/full#supplementary-material</ext-link></p>
<supplementary-material xlink:href="Table_1.DOCX" id="SM1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" xmlns:xlink="http://www.w3.org/1999/xlink"/>
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<ref-list>
<title>References</title>
<ref id="ref1"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Calvet</surname> <given-names>B.</given-names></name> <name><surname>P&#x00E9;ricaud</surname> <given-names>M.</given-names></name> <name><surname>Parneix</surname> <given-names>M.</given-names></name> <name><surname>Jouette</surname> <given-names>A.</given-names></name> <name><surname>Bricaud</surname> <given-names>M.</given-names></name> <name><surname>Cl&#x00E9;ment</surname> <given-names>J. P.</given-names></name></person-group> (<year>2016</year>). <article-title>Age and sex differences in temperament and character dimensions in a French nonclinical population</article-title>. <source>J. Individ. Differ.</source> <volume>37</volume>, <fpage>168</fpage>&#x2013;<lpage>180</lpage>. doi: <pub-id pub-id-type="doi">10.1027/1614-0001/a000203</pub-id></citation></ref>
<ref id="ref2"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Caspi</surname> <given-names>A.</given-names></name> <name><surname>Roberts</surname> <given-names>B. W.</given-names></name> <name><surname>Shiner</surname> <given-names>R. L.</given-names></name></person-group> (<year>2005</year>). <article-title>Personality development: stability and change</article-title>. <source>Annu. Rev. Psychol.</source> <volume>56</volume>, <fpage>453</fpage>&#x2013;<lpage>484</lpage>. doi: <pub-id pub-id-type="doi">10.1146/annurev.psych.55.090902.141913</pub-id></citation></ref>
<ref id="ref3"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cervone</surname> <given-names>D.</given-names></name></person-group> (<year>2005</year>). <article-title>Personality architecture: within-person structures and processes</article-title>. <source>Annu. Rev. Psychol.</source> <volume>56</volume>, <fpage>423</fpage>&#x2013;<lpage>452</lpage>. doi: <pub-id pub-id-type="doi">10.1146/annurev.psych.56.091103.070133</pub-id>, PMID: <pub-id pub-id-type="pmid">15709942</pub-id></citation></ref>
<ref id="ref4"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Choi</surname> <given-names>J. Y.</given-names></name> <name><surname>Lee</surname> <given-names>J. Y.</given-names></name></person-group> (<year>2022</year>). <article-title>Association between personality profiles and symptomatology patterns based on TCI and MMPI-2-RF in a transdiagnostic psychiatric sample: a person-centered approach</article-title>. <source>J. Psychiatr. Res.</source> <volume>155</volume>, <fpage>347</fpage>&#x2013;<lpage>354</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jpsychires.2022.09.031</pub-id>, PMID: <pub-id pub-id-type="pmid">36179415</pub-id></citation></ref>
<ref id="ref5"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>1987</year>). <article-title>A systematic method for clinical description and classification of personality variants</article-title>. <source>Arch. Gen. Psychiatry</source> <volume>44</volume>, <fpage>573</fpage>&#x2013;<lpage>588</lpage>. doi: <pub-id pub-id-type="doi">10.1001/archpsyc.1987.01800180093014</pub-id></citation></ref>
<ref id="ref6"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>1999</year>). <source>The temperament and character inventory-revised</source>. <publisher-name>Center for Psychobiology of Personality, Washington University</publisher-name>. <publisher-loc>St. Louis</publisher-loc></citation></ref>
<ref id="ref7"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2000</year>). <article-title>A practical way to diagnosis personality disorder: a proposal</article-title>. <source>J. Personal. Disord.</source> <volume>14</volume>, <fpage>99</fpage>&#x2013;<lpage>108</lpage>. doi: <pub-id pub-id-type="doi">10.1521/pedi.2000.14.2.99</pub-id>, PMID: <pub-id pub-id-type="pmid">10897461</pub-id></citation></ref>
<ref id="ref8"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2003</year>). &#x201C;<article-title>Completing the psychobiological architecture of human personality development: temperament, character, and coherence</article-title>&#x201D; in <source>Understanding Human Development</source>. eds. <person-group person-group-type="editor"><name><surname>Staudinger</surname> <given-names>U. M.</given-names></name> <name><surname>Lindenberger</surname> <given-names>U.</given-names></name></person-group> (<publisher-loc>Germany</publisher-loc>: <publisher-name>Springer</publisher-name>), <fpage>159</fpage>&#x2013;<lpage>181</lpage>.</citation></ref>
<ref id="ref9"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2004</year>). <source>Feeling good: The science of well-being</source>. <publisher-name>Oxford University Press</publisher-name>. <publisher-loc>England</publisher-loc></citation></ref>
<ref id="ref10"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2009</year>). <article-title>Evolution of human brain functions: the functional structure of human consciousness</article-title>. <source>Aust. N. Z. J. Psychiatry</source> <volume>43</volume>, <fpage>994</fpage>&#x2013;<lpage>1006</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00048670903270506</pub-id></citation></ref>
<ref id="ref11"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2013</year>). <article-title>What makes people healthy, happy, and fulfilled in the face of current world challenges?</article-title> <source>Mens Sana Monographs</source> <volume>11</volume>, <fpage>16</fpage>&#x2013;<lpage>24</lpage>. doi: <pub-id pub-id-type="doi">10.4103/0973-1229.109288</pub-id>, PMID: <pub-id pub-id-type="pmid">23678235</pub-id></citation></ref>
<ref id="ref12"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name></person-group> (<year>2013</year>). <article-title>People create health: effective health promotion is a creative process</article-title>. <source>Int. J. Per.s Cent. Med.</source> <volume>3</volume>, <fpage>114</fpage>&#x2013;<lpage>122</lpage>. doi: <pub-id pub-id-type="doi">10.5750/ijpcm.v3i2.399.People</pub-id>, PMID: <pub-id pub-id-type="pmid">26294956</pub-id></citation></ref>
<ref id="ref13"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Keltikangas-J&#x00E4;rvinen</surname> <given-names>L.</given-names></name></person-group> (<year>2019</year>). <article-title>The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings</article-title>. <source>Transl. Psychiatry</source> <volume>9</volume>:<fpage>290</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41398-019-0621-4</pub-id>, PMID: <pub-id pub-id-type="pmid">31712636</pub-id></citation></ref>
<ref id="ref14"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Svrakic</surname> <given-names>N. M.</given-names></name> <name><surname>Svrakic</surname> <given-names>D. M.</given-names></name></person-group> (<year>1997</year>). <article-title>Role of personality self-organization in development of mental order and disorder</article-title>. <source>Dev. Psychopathol.</source> <volume>9</volume>, <fpage>881</fpage>&#x2013;<lpage>906</lpage>. doi: <pub-id pub-id-type="doi">10.1017/s095457949700148x</pub-id>, PMID: <pub-id pub-id-type="pmid">9449010</pub-id></citation></ref>
<ref id="ref15"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Zohar</surname> <given-names>A. H.</given-names></name></person-group> (<year>2011</year>). <article-title>Personality and the perception of health and happiness</article-title>. <source>J. Affect. Disord.</source> <volume>128</volume>, <fpage>24</fpage>&#x2013;<lpage>32</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jad.2010.06.012</pub-id></citation></ref>
<ref id="ref16"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Zwir</surname> <given-names>I.</given-names></name></person-group> (<year>2018</year>). <article-title>What is the natural measurement unit of temperament: single traits or profiles?</article-title> <source>Philos. Trans. R. Soc. Lond. B. Biol. Sci.</source> <volume>373</volume>:<fpage>20170163</fpage>. doi: <pub-id pub-id-type="doi">10.1098/rstb.2017.0163</pub-id>, PMID: <pub-id pub-id-type="pmid">29483348</pub-id></citation></ref>
<ref id="ref17"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Zwir</surname> <given-names>I.</given-names></name></person-group> (<year>2022</year>). <source>Genetics of human character and temperament</source>. (pp. <fpage>1</fpage>&#x2013;<lpage>24</lpage>). <publisher-name>John Wiley &#x0026; Sons, Ltd.</publisher-name> <publisher-loc>United States</publisher-loc></citation></ref>
<ref id="ref18"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>De Fruyt</surname> <given-names>F.</given-names></name> <name><surname>Van De Wiele</surname> <given-names>L.</given-names></name> <name><surname>Van Heeringen</surname> <given-names>C.</given-names></name></person-group> (<year>2000</year>). <article-title>Cloninger&#x2019;s psychobiological model of temperament and character and the five-factor model of personality</article-title>. <source>Personal. Individ. Differ.</source> <volume>29</volume>, <fpage>441</fpage>&#x2013;<lpage>452</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0191-8869(99)00204-4</pub-id></citation></ref>
<ref id="ref19"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Espinoza</surname> <given-names>J. A.</given-names></name> <name><surname>Daljeet</surname> <given-names>K. N.</given-names></name> <name><surname>Meyer</surname> <given-names>J. P.</given-names></name></person-group> (<year>2020</year>). <article-title>Establishing the structure and replicability of personality profiles using the HEXACO-PI-R</article-title>. <source>Nat. Hum. Behav.</source> <volume>4</volume>, <fpage>713</fpage>&#x2013;<lpage>724</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41562-020-0853-6</pub-id>, PMID: <pub-id pub-id-type="pmid">32251375</pub-id></citation></ref>
<ref id="ref20"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Field</surname> <given-names>A.</given-names></name></person-group> (<year>2012</year>). <source>Discovering statistics using IBM SPSS statistics</source>. <publisher-name>Sage</publisher-name>. <publisher-loc>California</publisher-loc></citation></ref>
<ref id="ref21"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Garcia</surname> <given-names>D.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2023</year>). <article-title>Coherence of character and temperament drives personality change toward well being in person-centered therapy</article-title>. <source>Curr. Opin. Psychiatry</source> <volume>36</volume>, <fpage>60</fpage>&#x2013;<lpage>66</lpage>. doi: <pub-id pub-id-type="doi">10.1097/YCO.0000000000000833</pub-id>, PMID: <pub-id pub-id-type="pmid">36449732</pub-id></citation></ref>
<ref id="ref22"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Garcia</surname> <given-names>D.</given-names></name> <name><surname>Kazemitabar</surname> <given-names>M.</given-names></name> <name><surname>Stoyanova</surname> <given-names>K.</given-names></name> <name><surname>Stoyanov</surname> <given-names>D.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2022</year>). <article-title>Differences in subjective well-being between individuals with distinct joint personality (temperament-character) networks in a Bulgarian sample</article-title>. <source>PeerJ</source> <volume>10</volume>:<fpage>e13956</fpage>. doi: <pub-id pub-id-type="doi">10.7717/peerj.13956</pub-id>, PMID: <pub-id pub-id-type="pmid">36046505</pub-id></citation></ref>
<ref id="ref23"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Garcia</surname> <given-names>D.</given-names></name> <name><surname>Lester</surname> <given-names>N.</given-names></name> <name><surname>Lucchese</surname> <given-names>F.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2019</year>). &#x201C;<article-title>Personality and the brain: person-centered approaches</article-title>&#x201D; in <source>Personality and brain disorders. Associations and interventions</source>. eds. <person-group person-group-type="editor"><name><surname>Garcia</surname> <given-names>D.</given-names></name> <name><surname>Archer</surname> <given-names>T.</given-names></name> <name><surname>Kostrzewa</surname> <given-names>R. M.</given-names></name></person-group> (<publisher-loc>Germany</publisher-loc>: <publisher-name>Springer</publisher-name>), <fpage>3</fpage>&#x2013;<lpage>4</lpage>.</citation></ref>
<ref id="ref24"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gillespie</surname> <given-names>N. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Heath</surname> <given-names>A. C.</given-names></name> <name><surname>Martin</surname> <given-names>N. G.</given-names></name></person-group> (<year>2003</year>). <article-title>The genetic and environmental relationship between Cloninger&#x2019;s dimensions of temperament and character</article-title>. <source>Personal. Individ. Differ.</source> <volume>35</volume>, <fpage>1931</fpage>&#x2013;<lpage>1946</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0191-8869(03)00042-4</pub-id>, PMID: <pub-id pub-id-type="pmid">26028794</pub-id></citation></ref>
<ref id="ref25"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Goldberg</surname> <given-names>L. R.</given-names></name> <name><surname>Sweeney</surname> <given-names>D.</given-names></name> <name><surname>Merenda</surname> <given-names>P. F.</given-names></name> <name><surname>Hughes</surname> <given-names>J. E.</given-names> <suffix>Jr.</suffix></name></person-group> (<year>1998</year>). <article-title>Demographic variables and personality: the effects of gender, age, education, and ethnic/racial status on self-descriptions of personality attributes</article-title>. <source>Personal. Individ. Differ.</source> <volume>24</volume>, <fpage>393</fpage>&#x2013;<lpage>403</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0191-8869(97)00110-4</pub-id></citation></ref>
<ref id="ref26"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Goldman</surname> <given-names>R. G.</given-names></name> <name><surname>Skodal</surname> <given-names>A. E.</given-names></name> <name><surname>McGrath</surname> <given-names>P. J.</given-names></name> <name><surname>Oldham</surname> <given-names>J. M.</given-names></name></person-group> (<year>1994</year>). <article-title>Relationship between the tridimensional personality questionnaire and DSM-II-R personality traits</article-title>. <source>Am. J. Psychiatr.</source> <volume>151</volume>, <fpage>274</fpage>&#x2013;<lpage>276</lpage>. doi: <pub-id pub-id-type="doi">10.1176/ajp.151.2.274</pub-id></citation></ref>
<ref id="ref27"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Goncalves</surname> <given-names>D. M.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2010</year>). <article-title>Validation and normative studies of the Brazilian Portuguese and American versions of the temperament and character inventory-revised (TCI-R)</article-title>. <source>J. Affect. Disord.</source> <volume>124</volume>, <fpage>126</fpage>&#x2013;<lpage>133</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jad.2009.11.007</pub-id>, PMID: <pub-id pub-id-type="pmid">19942293</pub-id></citation></ref>
<ref id="ref28"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Grucza</surname> <given-names>R. A.</given-names></name> <name><surname>Goldberg</surname> <given-names>L. R.</given-names></name></person-group> (<year>2007</year>). <article-title>The comparative validity of 11 modern personality inventories: predictions of behavioral acts, informant reports, and clinical indicators</article-title>. <source>J. Pers. Assess.</source> <volume>89</volume>, <fpage>167</fpage>&#x2013;<lpage>187</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00223890701468568</pub-id></citation></ref>
<ref id="ref29"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gusnard</surname> <given-names>D. A.</given-names></name> <name><surname>Ollinger</surname> <given-names>J. M.</given-names></name> <name><surname>Shulman</surname> <given-names>G. L.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Price</surname> <given-names>J. L.</given-names></name> <name><surname>Van Essen</surname> <given-names>D. C.</given-names></name> <etal/></person-group>. (<year>2003</year>). <article-title>Persistence and brain circuitry</article-title>. <source>Proc. Natl. Acad. Sci. U. S. A.</source> <volume>100</volume>, <fpage>3479</fpage>&#x2013;<lpage>3484</lpage>. doi: <pub-id pub-id-type="doi">10.1073/pnas.0538050100</pub-id>, PMID: <pub-id pub-id-type="pmid">12626765</pub-id></citation></ref>
<ref id="ref30"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hirsh</surname> <given-names>J. B.</given-names></name> <name><surname>DeYoung</surname> <given-names>C. G.</given-names></name> <name><surname>Peterson</surname> <given-names>J. B.</given-names></name></person-group> (<year>2009</year>). <article-title>Metatraits of the big five differentially predict engagement and restraint of behavior</article-title>. <source>J. Pers.</source> <volume>77</volume>, <fpage>1085</fpage>&#x2013;<lpage>1102</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1467-6494.2009.00575.x</pub-id>, PMID: <pub-id pub-id-type="pmid">19558442</pub-id></citation></ref>
<ref id="ref31"><citation citation-type="book"><person-group person-group-type="author"><name><surname>Inglehart</surname> <given-names>R.F.</given-names></name></person-group> (<year>2018</year>). <source>Cultural evolution: People's motivations are changing, and reshaping the world</source>. <publisher-name>Cambridge University Press</publisher-name>: <publisher-loc>Cambridge, U.K.</publisher-loc>, <comment>2018</comment>, doi: <pub-id pub-id-type="doi">10.1017/9781108613880</pub-id></citation></ref>
<ref id="ref32"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Josefsson</surname> <given-names>K.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Hintsanen</surname> <given-names>M.</given-names></name> <name><surname>Jokela</surname> <given-names>M.</given-names></name> <name><surname>Pulkki-R&#x00E5;back</surname> <given-names>L.</given-names></name> <name><surname>Keltikangas-J&#x00E4;rvinen</surname> <given-names>L.</given-names></name></person-group> (<year>2011</year>). <article-title>Associations of personality profiles with various aspects of well-being: a population-based study</article-title>. <source>J. Affect. Disord.</source> <volume>133</volume>, <fpage>265</fpage>&#x2013;<lpage>273</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jad.2011.03.023</pub-id></citation></ref>
<ref id="ref33"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Josefsson</surname> <given-names>K.</given-names></name> <name><surname>Jokela</surname> <given-names>M.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Hintsanen</surname> <given-names>M.</given-names></name> <name><surname>Salo</surname> <given-names>J.</given-names></name> <name><surname>Hintsa</surname> <given-names>T.</given-names></name> <etal/></person-group>. (<year>2013</year>). <article-title>Maturity and change in personality: developmental trends of temperament and character in adulthood</article-title>. <source>Dev. Psychopathol.</source> <volume>25</volume>, <fpage>713</fpage>&#x2013;<lpage>727</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S0954579413000126</pub-id>, PMID: <pub-id pub-id-type="pmid">23880387</pub-id></citation></ref>
<ref id="ref34"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Krebs</surname> <given-names>R. M.</given-names></name> <name><surname>Schott</surname> <given-names>B. H.</given-names></name> <name><surname>D&#x00FC;zel</surname> <given-names>E.</given-names></name></person-group> (<year>2009</year>). <article-title>Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia Nigra/ventral tegmental area</article-title>. <source>Biol. Psychiatry</source> <volume>65</volume>, <fpage>103</fpage>&#x2013;<lpage>110</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.biopsych.2008.08.019</pub-id></citation></ref>
<ref id="ref35"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname> <given-names>S. J.</given-names></name> <name><surname>Park</surname> <given-names>S. H.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Chae</surname> <given-names>H.</given-names></name></person-group> (<year>2018</year>). <article-title>Behavior problems and personality in Korean high school students</article-title>. <source>PeerJ</source> <volume>6</volume>:<fpage>e6106</fpage>. doi: <pub-id pub-id-type="doi">10.7717/peerj.6106</pub-id>, PMID: <pub-id pub-id-type="pmid">30581682</pub-id></citation></ref>
<ref id="ref36"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P.</given-names></name> <name><surname>Beutler</surname> <given-names>L. E.</given-names></name> <name><surname>Gon&#x00E7;alves</surname> <given-names>&#x00D3;. F.</given-names></name></person-group> (<year>2008</year>). <article-title>Narrative change in psychotherapy: differences between good and bad outcome cases in cognitive, narrative, and prescriptive therapies</article-title>. <source>J. Clin. Psychol.</source> <volume>64</volume>, <fpage>1181</fpage>&#x2013;<lpage>1194</lpage>. doi: <pub-id pub-id-type="doi">10.1002/jclp.20517</pub-id></citation></ref>
<ref id="ref37"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Dinis</surname> <given-names>L.</given-names></name> <name><surname>S&#x00E1;</surname> <given-names>L.</given-names></name> <name><surname>Oliveira</surname> <given-names>J. T.</given-names></name> <name><surname>Dias</surname> <given-names>A.</given-names></name> <etal/></person-group>. (<year>2015</year>). <article-title>Personality and well-being in adolescents</article-title>. <source>Front. Psychol.</source> <volume>5</volume>:<fpage>1494</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fpsyg.2014.01494</pub-id>, PMID: <pub-id pub-id-type="pmid">25610408</pub-id></citation></ref>
<ref id="ref38"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Rocha</surname> <given-names>M. J.</given-names></name> <name><surname>Oliveira</surname> <given-names>J. T.</given-names></name> <name><surname>Ferreira</surname> <given-names>N.</given-names></name> <name><surname>Gon&#x00E7;alves</surname> <given-names>D. M.</given-names></name> <etal/></person-group>. (<year>2017</year>). <article-title>The psychometrics of the European Portuguese version of the temperament and character inventory-revised</article-title>. <source>Psychol. Rep.</source> <volume>120</volume>, <fpage>1178</fpage>&#x2013;<lpage>1199</lpage>. doi: <pub-id pub-id-type="doi">10.1177/0033294117711914</pub-id>, PMID: <pub-id pub-id-type="pmid">28604231</pub-id></citation></ref>
<ref id="ref39"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P.</given-names></name> <name><surname>Crusellas</surname> <given-names>L.</given-names></name> <name><surname>S&#x00E1;</surname> <given-names>I.</given-names></name> <name><surname>Gomes</surname> <given-names>P.</given-names></name> <name><surname>Matias</surname> <given-names>C.</given-names></name></person-group> (<year>2010</year>). <article-title>Evaluation of a manual-based programme for the promotion of social and emotional skills in elementary school children: results from a 4-year study in Portugal</article-title>. <source>Health Promot. Int.</source> <volume>25</volume>, <fpage>309</fpage>&#x2013;<lpage>317</lpage>. doi: <pub-id pub-id-type="doi">10.1093/heapro/daq029</pub-id></citation></ref>
<ref id="ref40"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Cunha</surname> <given-names>D.</given-names></name> <name><surname>Inman</surname> <given-names>R.</given-names></name></person-group> (<year>2019</year>). <article-title>Achievement emotions questionnaire-mathematics (AEQ-M) in adolescents: factorial structure, measurement invariance and convergent validity with personality</article-title>. <source>Eur. J. Dev. Psychol.</source> <volume>16</volume>, <fpage>750</fpage>&#x2013;<lpage>762</lpage>. doi: <pub-id pub-id-type="doi">10.1080/17405629.2018.1548349</pub-id></citation></ref>
<ref id="ref41"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Faria</surname> <given-names>V.</given-names></name> <name><surname>Cunha</surname> <given-names>D.</given-names></name> <name><surname>Inman</surname> <given-names>R.</given-names></name> <name><surname>Rocha</surname> <given-names>M.</given-names></name></person-group> (<year>2020c</year>). <article-title>Applying the transtheoretical model to adolescent academic performance using a person-centered approach: a latent cluster analysis</article-title>. <source>Learn. Individ. Differ.</source> <volume>78</volume>:<fpage>101818</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.lindif.2019.101818</pub-id></citation></ref>
<ref id="ref42"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A.</given-names></name> <name><surname>Dias</surname> <given-names>M. A.</given-names></name></person-group> (<year>2019</year>). <article-title>Tests of factorial structure and measurement invariance for the student engagement instrument: evidence from middle and high school students</article-title>. <source>Int. J. School &#x0026; Educ. Psychol.</source> <volume>7</volume>, <fpage>174</fpage>&#x2013;<lpage>186</lpage>. doi: <pub-id pub-id-type="doi">10.1080/21683603.2017.1414004</pub-id></citation></ref>
<ref id="ref43"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name></person-group> (<year>2021</year>). <article-title>Psychometric properties of the comic style markers &#x2013; Portuguese version: applying bifactor and hierarchical approaches to studying broad versus narrow styles of humor. HUMOR</article-title>. <source>Int. J. Humor Res</source>. <volume>34</volume>, <fpage>537</fpage>&#x2013;<lpage>565</lpage>. doi: <pub-id pub-id-type="doi">10.1515/humor-2021-0039</pub-id></citation></ref>
<ref id="ref44"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2021a</year>). <article-title>Personality networks and emotional and behavioral problems: integrating temperament and character using latent profile and latent class analyses</article-title>. <source>Child Psychiatry Hum. Dev.</source> <volume>52</volume>, <fpage>856</fpage>&#x2013;<lpage>868</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s10578-020-01063-9</pub-id>, PMID: <pub-id pub-id-type="pmid">32989577</pub-id></citation></ref>
<ref id="ref45"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2022a</year>). <article-title>Humor and personality: temperament and character have different roles</article-title>. <source>Soc. Psychol. Personal. Sci.</source> <volume>13</volume>, <fpage>1246</fpage>&#x2013;<lpage>1258</lpage>. doi: <pub-id pub-id-type="doi">10.1177/19485506211066369</pub-id></citation></ref>
<ref id="ref46"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2022b</year>). <article-title>Reactance and personality: assessing psychological reactance using a biopsychosocial and person-centered approach</article-title>. <source>Curr. Psychol.</source> <volume>41</volume>, <fpage>7666</fpage>&#x2013;<lpage>7680</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s12144-020-01310-1</pub-id></citation></ref>
<ref id="ref47"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2022c</year>). <article-title>Virtues in action are related to the integration of both temperament and character: comparing the VIA classification of virtues and Cloninger&#x2019;s biopsychosocial model of personality</article-title>. <source>J. Posit. Psychol.</source> <volume>17</volume>, <fpage>858</fpage>&#x2013;<lpage>875</lpage>. doi: <pub-id pub-id-type="doi">10.1080/17439760.2021.1975158</pub-id></citation></ref>
<ref id="ref48"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2023a</year>). <article-title>Disentangling the personality pathways to well-being</article-title>. <source>Sci. Rep.</source> <volume>13</volume>:<fpage>3353</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41598-023-29642-5</pub-id>, PMID: <pub-id pub-id-type="pmid">36849800</pub-id></citation></ref>
<ref id="ref49"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2023b</year>). <article-title>O Invent&#x00E1;rio de Temperamento e Car&#x00E1;ter revisto (ITC-R): Normas para a popula&#x00E7;&#x00E3;o Portuguesa [The Revised Temperament and Character Inventory (TCI-R): Normative data for the Portuguese population]</article-title>. <source>Psychologica</source> <volume>66</volume>:<fpage>e066001</fpage>. doi: <pub-id pub-id-type="doi">10.14195/1647-8606_66_1</pub-id></citation></ref>
<ref id="ref50"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2021b</year>). <article-title>Student engagement with school and personality: a biopsychosocial and person-centred approach</article-title>. <source>Br. J. Educ. Psychol.</source> <volume>91</volume>, <fpage>691</fpage>&#x2013;<lpage>713</lpage>. doi: <pub-id pub-id-type="doi">10.1111/bjep.12388</pub-id>, PMID: <pub-id pub-id-type="pmid">33247604</pub-id></citation></ref>
<ref id="ref51"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cunha</surname> <given-names>D.</given-names></name></person-group> (<year>2020a</year>). <article-title>Addressing a need for valid measures of trait reactance in adolescents: a further test of the Hong reactance scale</article-title>. <source>J. Pers. Assess.</source> <volume>102</volume>, <fpage>357</fpage>&#x2013;<lpage>369</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00223891.2019.1585360</pub-id></citation></ref>
<ref id="ref52"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cunha</surname> <given-names>D.</given-names></name></person-group> (<year>2020b</year>). <article-title>The resistance to change scale: assessing dimensionality and associations with personality and wellbeing in adolescents</article-title>. <source>J. Pers. Assess.</source> <volume>102</volume>, <fpage>604</fpage>&#x2013;<lpage>615</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00223891.2019.1676761</pub-id>, PMID: <pub-id pub-id-type="pmid">31652084</pub-id></citation></ref>
<ref id="ref53"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Rosa</surname> <given-names>I.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Duarte</surname> <given-names>A.</given-names></name> <name><surname>Robert Cloninger</surname> <given-names>C.</given-names></name></person-group> (<year>2021c</year>). <article-title>The psychobiological model of personality and its association with student approaches to learning: integrating temperament and character</article-title>. <source>Scand. J. Educ. Res.</source> <volume>65</volume>, <fpage>693</fpage>&#x2013;<lpage>709</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00313831.2020.1739137</pub-id></citation></ref>
<ref id="ref54"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A.</given-names></name> <name><surname>Lee</surname> <given-names>V. E.</given-names></name></person-group> (<year>2020</year>). <article-title>School social organization influences adolescents' cognitive engagement with school: the role of school support for learning and of autonomy support</article-title>. <source>Learn. Individ. Differ.</source> <volume>80</volume>:<fpage>101885</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.lindif.2020.101885</pub-id></citation></ref>
<ref id="ref55"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Lopes</surname> <given-names>J. C.</given-names></name> <name><surname>Inman</surname> <given-names>R. A.</given-names></name> <name><surname>Cunha</surname> <given-names>O.</given-names></name></person-group> (<year>2022d</year>). <article-title>The personality of male prisoners: moving towards an integrated temperament-and-character-based theory of criminal and antisocial behavior</article-title>. <source>J. Crim. Just.</source> <volume>79</volume>:<fpage>101897</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jcrimjus.2022.101897</pub-id></citation></ref>
<ref id="ref56"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Oliveira</surname> <given-names>J. T.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Azevedo</surname> <given-names>C.</given-names></name> <name><surname>Sousa</surname> <given-names>A.</given-names></name> <name><surname>Castro</surname> <given-names>J.</given-names></name> <etal/></person-group>. (<year>2012</year>). <article-title>The psychometrics and validity of the junior temperament and character inventory in Portuguese adolescents</article-title>. <source>Compr. Psychiatry</source> <volume>53</volume>, <fpage>1227</fpage>&#x2013;<lpage>1236</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.comppsych.2012.04.014</pub-id>, PMID: <pub-id pub-id-type="pmid">22682682</pub-id></citation></ref>
<ref id="ref57"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Pedras</surname> <given-names>S.</given-names></name> <name><surname>Pombo</surname> <given-names>P.</given-names></name></person-group> (<year>2020d</year>). <article-title>Students` personality contributes more to academic performance than well-being and learning approach &#x2013; implications for sustainable develop-ment and education</article-title>. <source>Eur. J. Investig. Health Psychol. Educ.</source> <volume>10</volume>, <fpage>1132</fpage>&#x2013;<lpage>1149</lpage>. doi: <pub-id pub-id-type="doi">10.3390/ejihpe10040079</pub-id>, PMID: <pub-id pub-id-type="pmid">34542440</pub-id></citation></ref>
<ref id="ref58"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Pedras</surname> <given-names>S.</given-names></name> <name><surname>Silva</surname> <given-names>M.</given-names></name> <name><surname>Moreira</surname> <given-names>M.</given-names></name> <name><surname>Oliveira</surname> <given-names>J.</given-names></name></person-group> (<year>2021d</year>). <article-title>Personality, attachment and wellbeing in adolescents: effects of personality and attachment</article-title>. <source>J. Happiness Stud.</source> <volume>22</volume>, <fpage>1855</fpage>&#x2013;<lpage>1888</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s10902-020-00299-5</pub-id></citation></ref>
<ref id="ref59"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Moreira</surname> <given-names>P. A. S.</given-names></name> <name><surname>Pinto</surname> <given-names>M.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Rodrigues</surname> <given-names>D.</given-names></name> <name><surname>Silva</surname> <given-names>C. F.</given-names></name></person-group> (<year>2019</year>). <article-title>Understanding the experience of psychopathology after intimate partner violence: the role of personality</article-title>. <source>PeerJ</source> <volume>7</volume>:<fpage>e6647</fpage>. doi: <pub-id pub-id-type="doi">10.7717/peerj.6647</pub-id>, PMID: <pub-id pub-id-type="pmid">30956898</pub-id></citation></ref>
<ref id="ref60"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mulder</surname> <given-names>R. T.</given-names></name> <name><surname>Joyce</surname> <given-names>P. R.</given-names></name></person-group> (<year>1997</year>). <article-title>Temperament and the structure of personality disorder symptoms</article-title>. <source>Psychol. Med.</source> <volume>27</volume>, <fpage>99</fpage>&#x2013;<lpage>106</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S0033291796004114</pub-id></citation></ref>
<ref id="ref61"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Newberg</surname> <given-names>A. B.</given-names></name> <name><surname>D&#x2019;Aquili</surname> <given-names>E. G.</given-names></name></person-group> (<year>2000</year>). <article-title>The creative brain/ the creative mind</article-title>. <source>Zygon</source> <volume>35</volume>, <fpage>53</fpage>&#x2013;<lpage>68</lpage>. doi: <pub-id pub-id-type="doi">10.1111/0591-2385.00259</pub-id></citation></ref>
<ref id="ref62"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>P&#x00E9;lissolo</surname> <given-names>A.</given-names></name> <name><surname>Mallet</surname> <given-names>L.</given-names></name> <name><surname>Baleyte</surname> <given-names>J. M.</given-names></name> <name><surname>Michel</surname> <given-names>G.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Allilaire</surname> <given-names>J. F.</given-names></name> <etal/></person-group>. (<year>2005</year>). <article-title>The temperament and character inventory-revised (TCI-R): psychometric characteristics of the French version</article-title>. <source>Acta Psychiatr. Scand.</source> <volume>112</volume>, <fpage>126</fpage>&#x2013;<lpage>133</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1600-0447.2005.00551.x</pub-id>, PMID: <pub-id pub-id-type="pmid">15992394</pub-id></citation></ref>
<ref id="ref63"><citation citation-type="book"><person-group person-group-type="author"><collab id="coll1">R Core Team</collab></person-group> (<year>2021</year>). <source>R: A language and environment for statistical computing</source>. <publisher-name>R Foundation for Statistical Computing</publisher-name>. <publisher-loc>Austria</publisher-loc></citation></ref>
<ref id="ref64"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Rettew</surname> <given-names>D. C.</given-names></name> <name><surname>Althoff</surname> <given-names>R. R.</given-names></name> <name><surname>Dumenci</surname> <given-names>L.</given-names></name> <name><surname>Ayer</surname> <given-names>L.</given-names></name> <name><surname>Hudziak</surname> <given-names>J. J.</given-names></name></person-group> (<year>2008</year>). <article-title>Latent profiles of temperament and their relations to psychopathology and wellness</article-title>. <source>J. Am. Acad. Child Adolesc. Psychiatry</source> <volume>47</volume>, <fpage>273</fpage>&#x2013;<lpage>281</lpage>. doi: <pub-id pub-id-type="doi">10.1097/CHI.0b013e318160b403</pub-id>, PMID: <pub-id pub-id-type="pmid">18216734</pub-id></citation></ref>
<ref id="ref65"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sch&#x00FC;tz</surname> <given-names>E.</given-names></name> <name><surname>Archer</surname> <given-names>T.</given-names></name> <name><surname>Garcia</surname> <given-names>D.</given-names></name></person-group> (<year>2013</year>). <article-title>Character profiles and adolescents&#x2019; self-reported affect</article-title>. <source>Personal. Individ. Differ.</source> <volume>54</volume>, <fpage>841</fpage>&#x2013;<lpage>844</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.paid.2012.12.020</pub-id></citation></ref>
<ref id="ref66"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sievert</surname> <given-names>M.</given-names></name> <name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Lester</surname> <given-names>N.</given-names></name> <name><surname>Rozsa</surname> <given-names>S.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2016</year>). <article-title>The influence of temperament and character profiles on specialty choice and well-being in medical residents</article-title>. <source>PeerJ</source> <volume>4</volume>:<fpage>e2319</fpage>. doi: <pub-id pub-id-type="doi">10.7717/peerj.2319</pub-id>, PMID: <pub-id pub-id-type="pmid">27651982</pub-id></citation></ref>
<ref id="ref67"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Svrakic</surname> <given-names>D. M.</given-names></name> <name><surname>Whitehead</surname> <given-names>C.</given-names></name> <name><surname>Przybeck</surname> <given-names>T. R.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>1993</year>). <article-title>Differential diagnosis of personality disorders by the seven-factor model of temperament and character</article-title>. <source>Arch. Gen. Psychiatry</source> <volume>50</volume>, <fpage>991</fpage>&#x2013;<lpage>999</lpage>. doi: <pub-id pub-id-type="doi">10.1001/archpsyc.1993.01820240075009</pub-id>, PMID: <pub-id pub-id-type="pmid">8250685</pub-id></citation></ref>
<ref id="ref68"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Trouillet</surname> <given-names>R.</given-names></name> <name><surname>Gana</surname> <given-names>K.</given-names></name></person-group> (<year>2008</year>). <article-title>Age differences in temperament, character and depressive mood: a cross-sectional study</article-title>. <source>Clin. Psychol. Psychother.</source> <volume>15</volume>, <fpage>266</fpage>&#x2013;<lpage>275</lpage>. doi: <pub-id pub-id-type="doi">10.1002/cpp.580</pub-id>, PMID: <pub-id pub-id-type="pmid">19115447</pub-id></citation></ref>
<ref id="ref69"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Yin</surname> <given-names>K.</given-names></name> <name><surname>Lee</surname> <given-names>P.</given-names></name> <name><surname>Sheldon</surname> <given-names>O. J.</given-names></name> <name><surname>Li</surname> <given-names>C.</given-names></name> <name><surname>Zhao</surname> <given-names>J.</given-names></name></person-group> (<year>2021</year>). <article-title>Personality profiles based on the FFM: a systematic review with a person-centered approach</article-title>. <source>Personal. Individ. Differ.</source> <volume>180</volume>:<fpage>110996</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.paid.2021.110996</pub-id></citation></ref>
<ref id="ref70"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zohar</surname> <given-names>A. H.</given-names></name> <name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Wang</surname> <given-names>J.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name> <name><surname>Anokhin</surname> <given-names>A. P.</given-names></name></person-group> (<year>2019</year>). <article-title>The development of temperament and character during adolescence: the processes and phases of change</article-title>. <source>Dev. Psychopathol.</source> <volume>31</volume>, <fpage>601</fpage>&#x2013;<lpage>617</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S0954579418000159</pub-id>, PMID: <pub-id pub-id-type="pmid">29704900</pub-id></citation></ref>
<ref id="ref71"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Arnedo</surname> <given-names>J.</given-names></name> <name><surname>Del-Val</surname> <given-names>C.</given-names></name> <name><surname>Pulkki-R&#x00E5;back</surname> <given-names>L.</given-names></name> <name><surname>Konte</surname> <given-names>B.</given-names></name> <name><surname>Yang</surname> <given-names>S. S.</given-names></name> <etal/></person-group>. (<year>2020a</year>). <article-title>Uncovering the complex genetics of human character</article-title>. <source>Mol. Psychiatry</source> <volume>25</volume>, <fpage>2295</fpage>&#x2013;<lpage>2312</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41380-018-0263-6</pub-id>, PMID: <pub-id pub-id-type="pmid">30283034</pub-id></citation></ref>
<ref id="ref72"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Arnedo</surname> <given-names>J.</given-names></name> <name><surname>Del-Val</surname> <given-names>C.</given-names></name> <name><surname>Pulkki-R&#x00E5;back</surname> <given-names>L.</given-names></name> <name><surname>Konte</surname> <given-names>B.</given-names></name> <name><surname>Yang</surname> <given-names>S. S.</given-names></name> <etal/></person-group>. (<year>2020b</year>). <article-title>Uncovering the complex genetics of human temperament</article-title>. <source>Mol. Psychiatry</source> <volume>25</volume>, <fpage>2275</fpage>&#x2013;<lpage>2294</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41380-018-0264-5</pub-id>, PMID: <pub-id pub-id-type="pmid">30279457</pub-id></citation></ref>
<ref id="ref01"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Arnedo</surname> <given-names>J.</given-names></name> <name><surname>Mesa</surname> <given-names>A.</given-names></name> <name><surname>Del Val</surname> <given-names>C.</given-names></name> <name><surname>de Erausquin</surname> <given-names>G. A.</given-names></name> <name><surname>Cloninger</surname> <given-names>C. R.</given-names></name></person-group> (<year>2023</year>). <article-title>Temperament &#x0026; Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis</article-title>. <source>Mol. Psychiatry</source>. <fpage>1</fpage>&#x2013;<lpage>16</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41380-023-02039-6</pub-id></citation></ref>
<ref id="ref73"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Del-Val</surname> <given-names>C.</given-names></name> <name><surname>Arnedo</surname> <given-names>J.</given-names></name> <name><surname>Pulkki-R&#x00E5;back</surname> <given-names>L.</given-names></name> <name><surname>Konte</surname> <given-names>B.</given-names></name> <name><surname>Yang</surname> <given-names>S. S.</given-names></name> <etal/></person-group>. (<year>2021</year>). <article-title>Three genetic&#x2013;environmental networks for human personality</article-title>. <source>Mol. Psychiatry</source> <volume>26</volume>, <fpage>3858</fpage>&#x2013;<lpage>3875</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41380-019-0579-x</pub-id>, PMID: <pub-id pub-id-type="pmid">31748689</pub-id></citation></ref>
<ref id="ref74"><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zwir</surname> <given-names>I.</given-names></name> <name><surname>Del-Val</surname> <given-names>C.</given-names></name> <name><surname>Hintsanen</surname> <given-names>M.</given-names></name> <name><surname>Cloninger</surname> <given-names>K. M.</given-names></name> <name><surname>Romero-Zaliz</surname> <given-names>R.</given-names></name> <name><surname>Mesa</surname> <given-names>A.</given-names></name> <etal/></person-group>. (<year>2022</year>). <article-title>Evolution of genetic networks for human creativity</article-title>. <source>Mol. Psychiatry</source> <volume>27</volume>, <fpage>354</fpage>&#x2013;<lpage>376</lpage>. doi: <pub-id pub-id-type="doi">10.1038/s41380-021-01097-y</pub-id></citation></ref></ref-list>
</back>
</article>