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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychol.</journal-id>
<journal-title>Frontiers in Psychology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychol.</abbrev-journal-title>
<issn pub-type="epub">1664-1078</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyg.2023.1095616</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychology</subject>
<subj-group>
<subject>Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Mapping the scientific research on integrated care: a bibliometric and social network analysis</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Guo</surname>
<given-names>Dandan</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2093587/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhou</surname>
<given-names>Chaofeng</given-names>
</name>
<xref rid="aff2" ref-type="aff"><sup>2</sup></xref>
<xref rid="aff3" ref-type="aff"><sup>3</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2424798/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Li</surname>
<given-names>Haomiao</given-names>
</name>
<xref rid="aff4" ref-type="aff"><sup>4</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1548031/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Su</surname>
<given-names>Dai</given-names>
</name>
<xref rid="aff5" ref-type="aff"><sup>5</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1564689/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gong</surname>
<given-names>Guangwen</given-names>
</name>
<xref rid="aff6" ref-type="aff"><sup>6</sup></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Xinlin</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<xref rid="aff7" ref-type="aff"><sup>7</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2006654/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chen</surname>
<given-names>Xinlan</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<xref rid="aff8" ref-type="aff"><sup>8</sup></xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Chen</surname>
<given-names>Yingchun</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<xref rid="aff9" ref-type="aff"><sup>9</sup></xref>
<xref rid="c001" ref-type="corresp"><sup>&#x002A;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1846463/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<aff id="aff2"><sup>2</sup><institution>Wuhan Library, Chinese Academy of Sciences</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Library, Information and Archives Management, School of Economic and Management, UCAS</institution>, <addr-line>Beijing</addr-line>, <country>China</country></aff>
<aff id="aff4"><sup>4</sup><institution>School of Political Science and Public Administration, Wuhan University</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<aff id="aff5"><sup>5</sup><institution>Department of Health Management and Policy, School of Public Health, Capital Medical University</institution>, <addr-line>Beijing</addr-line>, <country>China</country></aff>
<aff id="aff6"><sup>6</sup><institution>Guangwen Gong, School of Management, Hubei University of Chinese Medicine</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<aff id="aff7"><sup>7</sup><institution>Union Hospital, Tongji Medical College, Huazhong University of Science and Technology</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<aff id="aff8"><sup>8</sup><institution>Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<aff id="aff9"><sup>9</sup><institution>Research Centre for Rural Health Service, Key Research Institute of Humanities and Social Sciences of Hubei Provincial Department of Education</institution>, <addr-line>Wuhan</addr-line>, <country>China</country></aff>
<author-notes>
<fn id="fn0001" fn-type="edited-by"><p>Edited by: Maximilian Pangratius de Courten, Victoria University, Australia</p></fn>
<fn id="fn0002" fn-type="edited-by"><p>Reviewed by: Juan Du, Capital Medical University, China; Theo Van Der Voordt, Delft University of Technology, Netherlands</p></fn>
<corresp id="c001">&#x002A;Correspondence: Yingchun Chen, <email>chenyingchunhust@163.com</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>14</day>
<month>09</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>14</volume>
<elocation-id>1095616</elocation-id>
<history>
<date date-type="received">
<day>11</day>
<month>11</month>
<year>2022</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>08</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2023 Guo, Zhou, Li, Su, Gong, Chen, Chen and Chen.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Guo, Zhou, Li, Su, Gong, Chen, Chen and Chen</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Background</title>
<p>Integrated care (IC) is the cornerstone of the sustainable development of the medical and health system. A thorough examination of the existing scientific literature on IC is essential for assessing the present state of knowledge on this subject. This review seeks to offer an overview of evidence-based knowledge, pinpoint existing knowledge gaps related to IC, and identify areas requiring further research.</p>
</sec>
<sec id="sec2">
<title>Methods</title>
<p>Data were retrieved from the Web of Science Core Collection, from 2010 to 2020. Bibliometrics and social network analysis were used to explore and map the knowledge structure, research hotspots, development status, academic groups and future development trends of IC.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>A total of 7,501 articles were obtained. The number of publications on IC was rising in general. Healthcare science services were the most common topics. The United States contributed the highest number of articles. The level of collaboration between countries and between authors was found to be relatively low. The keywords were stratified into four clusters: IC, depression, integrative medicine, and primary health care. In recent years, complementary medicine has become a hotspot and will continue to be a focus.</p>
</sec>
<sec id="sec4">
<title>Conclusion</title>
<p>The study provides a comprehensive analysis of global research hotspots and trends in IC, and highlights the characteristics, challenges, and potential solutions of IC. To address resource fragmentation, collaboration difficulties, insufficient financial incentives, and poor information sharing, international collaboration needs to be strengthened to promote value co-creation and model innovation in IC. The contribution of this study lies in enhancing people&#x2019;s understanding of the current state of IC research, guiding scholars to discover new research perspectives, and providing valuable references for researchers and policymakers in designing and implementing effective IC strategies.</p>
</sec>
</abstract>
<kwd-group>
<kwd>integrated care</kwd>
<kwd>bibliometric</kwd>
<kwd>social network analysis</kwd>
<kwd>Citespace</kwd>
<kwd>Web of Science</kwd>
</kwd-group>
<counts>
<fig-count count="8"/>
<table-count count="7"/>
<equation-count count="0"/>
<ref-count count="87"/>
<page-count count="15"/>
<word-count count="10054"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Psychology for Clinical Settings</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<label>1.</label>
<title>Introduction</title>
<p>With the changes in disease spectrum, the influence of social, natural environment and lifestyle on health became increasingly prominent. However, the fragmented healthcare service system and the single clinical discipline treatment method cannot effectively respond to patient requirements. In response to the challenges being faced by health systems, the World Health Organization (WHO) proposed the Integration of Health Care Delivery (IHCD) in 1996 (<xref ref-type="bibr" rid="ref40">Integration of Health Care Delivery, 1996</xref>), and People-Centered Integrated Care (PCIC) strategy in 2015 (<xref ref-type="bibr" rid="ref82">World Health Organization, 2015</xref>). These initiatives reflect the growing recognition of the importance of IC in improving health outcomes. However, the literature suggests that there is no single definition of IC, defining IC is an ongoing process, and its definition continues to evolve as the health system and environment change (<xref ref-type="bibr" rid="ref42">Kodner and Spreeuwenberg, 2002</xref>; <xref ref-type="bibr" rid="ref48">Lennox-Chhugani, 2021</xref>). Despite the absence of a clear definition, scholars have reached some consensus on the fundamental principles and goals of IC, and countries worldwide have been exploring tailored IC practices that suit their national contexts, which have demonstrated improvements in quality, efficiency, accessibility, and cost management of healthcare systems (<xref ref-type="bibr" rid="ref72">Sweeney et al., 2007</xref>; <xref ref-type="bibr" rid="ref29">Dudley and Garner, 2011</xref>; <xref ref-type="bibr" rid="ref52">Maruthappu et al., 2015</xref>; <xref ref-type="bibr" rid="ref23">Coates et al., 2022</xref>). Moreover, numerous studies have shown that achieving IC can generate significant health benefits, especially for the older populations, those with chronic conditions, the mentally ill, and other special people who need long-term care, such as reducing anxiety and fatigue in cancer patients, improving quality-adjusted life years in pediatric patients with asthma, and improving health-related quality of life while decreasing behavioral problems, as well as reducing caregiver burden in dementia patients (<xref ref-type="bibr" rid="ref47">Lengacher et al., 2009</xref>; <xref ref-type="bibr" rid="ref2">Andersen, 2014</xref>; <xref ref-type="bibr" rid="ref70">Sun et al., 2019</xref>; <xref ref-type="bibr" rid="ref30">Duenas-Meza et al., 2020</xref>; <xref ref-type="bibr" rid="ref61">Schad et al., 2020</xref>; <xref ref-type="bibr" rid="ref34">Ha et al., 2021</xref>). Some studies also showed that patients who received a fully integrated primary-secondary care model were more satisfied than patients who received treatment separately from the primary or secondary care sectors, and such patients could achieve better health outcomes (<xref ref-type="bibr" rid="ref75">Uga et al., 2017</xref>; <xref ref-type="bibr" rid="ref79">van Olmen et al., 2020</xref>; <xref ref-type="bibr" rid="ref28">Donald et al., 2021</xref>). In addition, IC expands the perspective of clinical care from the biomedical to the biopsychosocial by treating comorbid psychiatric illness; IC also has significant effects on controlling symptoms and improving the physical fitness of schizophrenic patients (<xref ref-type="bibr" rid="ref66">Smith, 2009</xref>; <xref ref-type="bibr" rid="ref63">Sharpe et al., 2020</xref>). IC has become increasingly important in health care policy, multidisciplinary collaboration and clinical practice as a means to achieve high-quality services (<xref ref-type="bibr" rid="ref49">Lewis et al., 2018</xref>).</p>
<p>From an academic perspective, extensive systematic reviews on IC have been undertaken with various goals in the past 10&#x2009;years. For example, <xref ref-type="bibr" rid="ref39">Hughes et al. (2020)</xref> identified an array of strategies and conceptual work of IC. <xref ref-type="bibr" rid="ref87">Zonneveld et al., (2018)</xref> developed a set of underlying values of IC and discussed the practical applications and their uses. <xref ref-type="bibr" rid="ref59">Rocks et al. (2020)</xref> evaluated the economic benefits of IC and suggested that IC is likely to reduce costs and improve outcomes. <xref ref-type="bibr" rid="ref11">Bautista et al. (2016)</xref> developed a comprehensive framework to provide evidence on the state of the art in measuring IC. Overall, many studies have been undertaken on IC, but these analyses have mainly focused on specific aspects of IC, and comprehensive systematic analyses have been limited. Bibliometrics could quantitatively analyze scientific publications, but few bibliometric studies have been performed on research relating to IC. In 2013, Sun used the Bibliographic Item Co-occurrence Matrix Builder and SPSS to analyze the growth pattern, jurisdiction distribution, core journals and key research domains of IC (<xref ref-type="bibr" rid="ref71">Sun et al., 2014</xref>). Li retrieved articles from 1997 to 2016, used Histcite and VOS viewer to analyze publication numbers and citations, and co-authorship between countries and institutions and clusters of IC (<xref ref-type="bibr" rid="ref85">Li et al., 2020</xref>). However, these two studies lacked the most recent data, single analysis tool was used and the data could not be fully mined. Therefore, we use a variety of tools to comprehensively analyze the status of IC through bibliometric analysis and social network analysis (SNA) to reveal the development status in multiple dimensions of IC to date. Specifically, we use publication growth trend, disciplinary areas distribution, international productivity and collaboration, author productivity and collaboration, citation analysis and keyword occurrence research hotspots and trends.</p>
</sec>
<sec sec-type="materials|methods" id="sec6">
<label>2.</label>
<title>Materials and methods</title>
<sec id="sec7">
<label>2.1.</label>
<title>Data sources</title>
<p>Data illustrated here were retrieved from the Web of Science Core Collection (WOSCC), which is the most frequently used citation database for bibliometric analysis, and the structured data format provides considerable convenience to quantitative analysis. This study selects articles from four databases, namely, Science Citation Index Expanded, Social Sciences Citation Index, Conference Proceedings Citation Index-Science and Conference Proceedings Citation Index&#x2014;Social Science &#x0026; Humanities, as the data source.</p>
</sec>
<sec id="sec8">
<label>2.2.</label>
<title>Search strategy</title>
<p>Advanced search of WOSCC is used, and the research strategy was as follows: {[TS&#x2009;=&#x2009;(&#x201C;integrat&#x002A; care&#x201D; OR &#x201C;integrat&#x002A; health&#x201D; OR &#x201C;integrat&#x002A; healthcare&#x201D; OR &#x201C;care integration&#x201D; OR &#x201C;integrat&#x002A; of care&#x201D; OR &#x201C;integrat&#x002A; medic&#x002A;&#x201D;)]}. The publication time span was limited to 2010.10.1&#x2013;2020.10.12, and 7,501 publications were collected. Document Type: Article.</p>
</sec>
<sec id="sec9">
<label>2.3.</label>
<title>Analysis methods</title>
<sec id="sec10">
<label>2.3.1.</label>
<title>Bibliometrics analysis method</title>
<p>Bibliometrics is one of the key methods to objectively measure the influence of academic publications (<xref ref-type="bibr" rid="ref1">Agarwal et al., 2016</xref>). It uses methods such as mathematical modeling, statistical analysis and SNA to explore the knowledge structure, research hotspots, development status, academic groups and future development trends of a certain field (<xref ref-type="bibr" rid="ref86">Zhu and Guan, 2013</xref>).</p>
<p>CiteSpace and VOSviewer visualization software were used to depict the national cooperative science knowledge mapping. Nodes represent the author, institution, country or cited reference. The links between nodes represent the collaboration or co-occurrence relationships. The thickness of the connection represents the strength of cooperation. The purple node indicates high BC and acts as pivotal points in a field (<xref ref-type="bibr" rid="ref19">Chen, 2006</xref>). In addition, we used Price&#x2019;s law, which is an indicator for analyzing productivity in a specific field (<xref ref-type="bibr" rid="ref51">L&#x00F3;pezmu&#x00F1;oz et al., 2013</xref>). The lower limit for the number of publications in the core author group or the lower limit of the frequency of high-frequency keywords (<italic>M</italic>) is <inline-formula><mml:math id="M1"><mml:mi>M</mml:mi><mml:mo>=</mml:mo><mml:mn>0.749</mml:mn><mml:msqrt><mml:mrow><mml:msub><mml:mi>N</mml:mi><mml:mtext>max</mml:mtext></mml:msub><mml:mspace width="0.25em"/></mml:mrow></mml:msqrt></mml:math></inline-formula>. N<sub>max</sub> represents the maximum value of the number of posts or the maximum value of frequency.</p>
</sec>
<sec id="sec11">
<label>2.3.2.</label>
<title>SNA</title>
<p>SNA is a method of studying nodes and their relationships. SNA can effectively identify the influence of each node and the interaction between nodes in the social network. The indicators to measure the influence of nodes are betweenness centrality (BC), closeness centrality (CC), and degree centrality (DC). BC represents the node&#x2019;s ability to control the connection between two non-adjacent nodes. The larger the value, the stronger the control ability of the entire network information flow, and is at the core of the entire network (<xref ref-type="bibr" rid="ref18">Chen, 2005</xref>). CC represents the distance between the nodes. The smaller the distance, the larger the value, indicating that the node is in an important position in the entire network. DC is the number of nodes directly connected to the node. The larger the value represents the higher the importance, but it does not mean that the node is in the center of the network (<xref ref-type="bibr" rid="ref73">Tonta and Darvish, 2010</xref>). Moreover, Ucinet and NetDraw were used for SNA in this study. Ucinet is a software package for social network analysis that provides tools for data management, analysis (<xref ref-type="bibr" rid="ref16">Borgatti et al., 2002</xref>), and visualization. It can be used to analyze social network data and identify patterns in the structure of relationships between individuals or organizations. NetDraw is a visualization tool that can be used in conjunction with Ucinet to create network diagrams and visualize social network data (<xref ref-type="bibr" rid="ref15">Borgatti, 2002</xref>; <xref ref-type="bibr" rid="ref25">Cronin, 2015</xref>).</p>
</sec>
</sec>
<sec id="sec12">
<label>2.4.</label>
<title>Tools</title>
<p>Firstly, we use Excel&#x2019;s bar graph to count the annual number of posts and the rate of change of posts (<xref rid="fig1" ref-type="fig">Figure 1</xref>). Secondly, we used the WOSCC Literature Analysis Report to find out the distribution of disciplinary areas (<xref rid="fig2" ref-type="fig">Figure 2</xref>). We then used BibExcel to extract the top 20 high-yield countries (<xref rid="tab1" ref-type="table">Table 1</xref>; <xref ref-type="bibr" rid="ref62">Persson et al., 2009</xref>). We used the CiteSpace visualization tool to depict the mapping of international productivity and collaboration (<xref rid="fig3" ref-type="fig">Figure 3</xref>; <xref ref-type="bibr" rid="ref19">Chen, 2006</xref>). Next, we use R Voice&#x2019;s BiblioMetrix to extract the number of articles posted by highly productive authors and other indexes (<xref rid="tab2" ref-type="table">Table 2</xref>; <xref ref-type="bibr" rid="ref5">Aria and Cuccurullo, 2017</xref>). Then, we used the Bibliographic Item Co-Occurrence Matrix Builder to extract the author co-occurrence matrix and imported SNA software Ucinet and NetDraw for drawing (<xref rid="fig4" ref-type="fig">Figure 4</xref>; <xref ref-type="bibr" rid="ref50">Liu, 2009</xref>). We then used BibExcel to extract high-frequency keywords (<xref rid="tab3" ref-type="table">Table 3</xref>) and used VOSviewer visualization software (<xref rid="fig5" ref-type="fig">Figure 5</xref>) to draw keyword co-occurrence knowledge mapping (keyword co-occurrence knowledge mapping) and the key in each word cluster (<xref rid="tab4" ref-type="table">Table 4</xref>; <xref ref-type="bibr" rid="ref78">van Eck and Waltman, 2010</xref>). Finally, we used CiteSpace to draw reference co-citation knowledge mapping (<xref rid="tab5" ref-type="table">Table 5</xref>; <xref rid="fig6" ref-type="fig">Figure 6</xref>), highly cited documents (<xref rid="tab6" ref-type="table">Table 6</xref>) and timelines (<xref rid="fig7" ref-type="fig">Figure 7</xref>). Specific tools and diagrams are shown in <xref rid="fig8" ref-type="fig">Figure 8</xref>.</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption><p>Annual article counts on IC from 2010 to 2020.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g001.tif"/>
</fig>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption><p>Distribution of disciplinary areas on IC.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g002.tif"/>
</fig>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption><p>Top 20 countries in terms of number of articles and BC.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Country</th>
<th align="left" valign="top">Territory</th>
<th align="center" valign="top">Frequency</th>
<th align="center" valign="top">BC</th>
<th align="left" valign="top">Country</th>
<th align="left" valign="top">Territory</th>
<th align="center" valign="top">Frequency</th>
<th align="center" valign="top">BC</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">USA</td>
<td align="left" valign="middle">North America</td>
<td align="center" valign="middle">4,113</td>
<td align="center" valign="middle">0.45</td>
<td align="left" valign="middle">Sweden</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">136</td>
<td align="center" valign="middle">0.06</td>
</tr>
<tr>
<td align="left" valign="middle">England</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">656</td>
<td align="center" valign="middle">0.16</td>
<td align="left" valign="middle">Belgium</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">0.06</td>
</tr>
<tr>
<td align="left" valign="middle">Australia</td>
<td align="left" valign="middle">Oceania</td>
<td align="center" valign="middle">501</td>
<td align="center" valign="middle">0.15</td>
<td align="left" valign="middle">South Africa</td>
<td align="left" valign="middle">Africa</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">0.12</td>
</tr>
<tr>
<td align="left" valign="middle">Netherlands</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">475</td>
<td align="center" valign="middle">0.15</td>
<td align="left" valign="middle">South Korea</td>
<td align="left" valign="middle">Asia</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">0.04</td>
</tr>
<tr>
<td align="left" valign="middle">Canada</td>
<td align="left" valign="middle">North America</td>
<td align="center" valign="middle">469</td>
<td align="center" valign="middle">0.05</td>
<td align="left" valign="middle">Brazil</td>
<td align="left" valign="middle">Latin America</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">0.05</td>
</tr>
<tr>
<td align="left" valign="middle">Germany</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">356</td>
<td align="center" valign="middle">0.11</td>
<td align="left" valign="middle">Denmark</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">0.05</td>
</tr>
<tr>
<td align="left" valign="middle">Peoples R China</td>
<td align="left" valign="middle">Asia</td>
<td align="center" valign="middle">312</td>
<td align="center" valign="middle">0.08</td>
<td align="left" valign="middle">Israel</td>
<td align="left" valign="middle">Asia</td>
<td align="center" valign="middle">11</td>
<td align="center" valign="middle">0.12</td>
</tr>
<tr>
<td align="left" valign="middle">Spain</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">189</td>
<td align="center" valign="middle">0.02</td>
<td align="left" valign="middle">France</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">0.06</td>
</tr>
<tr>
<td align="left" valign="middle">Italy</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">186</td>
<td align="center" valign="middle">0.08</td>
<td align="left" valign="middle">Norway</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">9</td>
<td align="center" valign="middle">0.01</td>
</tr>
<tr>
<td align="left" valign="middle">Switzerland</td>
<td align="left" valign="middle">Europe</td>
<td align="center" valign="middle">177</td>
<td align="center" valign="middle">0.07</td>
<td align="left" valign="middle">India</td>
<td align="left" valign="middle">Asia</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">0.04</td>
</tr>
</tbody>
</table>
</table-wrap>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption><p>International collaboration network of the 20 most productive countries.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g003.tif"/>
</fig>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption><p>Impact of top 20 most productive authors ranked by papers.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Ranking</th>
<th align="left" valign="top">Authors</th>
<th align="center" valign="top"># of papers</th>
<th align="center" valign="top">BC</th>
<th align="center" valign="top">CC</th>
<th align="center" valign="top">DC</th>
<th align="center" valign="top">h-index</th>
<th align="center" valign="top">g-index</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">1</td>
<td align="left" valign="middle">Ben-Arye E</td>
<td align="center" valign="middle">60</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">342</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">19</td>
</tr>
<tr>
<td align="left" valign="middle">2</td>
<td align="left" valign="middle">Schiff E</td>
<td align="center" valign="middle">43</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">342</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">17</td>
</tr>
<tr>
<td align="left" valign="middle">3</td>
<td align="left" valign="middle">Jacobsen SJ</td>
<td align="center" valign="middle">33</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">233</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">15</td>
<td align="center" valign="middle">29</td>
</tr>
<tr>
<td align="left" valign="middle">4</td>
<td align="left" valign="middle">Escobar GJ</td>
<td align="center" valign="middle">32</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">361</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">27</td>
</tr>
<tr>
<td align="left" valign="middle">5</td>
<td align="left" valign="middle">Go AS</td>
<td align="center" valign="middle">32</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">234</td>
<td align="center" valign="middle">3</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">32</td>
</tr>
<tr>
<td align="left" valign="middle">6</td>
<td align="left" valign="middle">Karter AJ</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">233</td>
<td align="center" valign="middle">4</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">31</td>
</tr>
<tr>
<td align="left" valign="middle">7</td>
<td align="left" valign="middle">Quesenberry CP</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">230</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">31</td>
</tr>
<tr>
<td align="left" valign="middle">8</td>
<td align="left" valign="middle">Samuels N</td>
<td align="center" valign="middle">31</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">342</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">12</td>
</tr>
<tr>
<td align="left" valign="middle">9</td>
<td align="left" valign="middle">Li J</td>
<td align="center" valign="middle">26</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">380</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">19</td>
</tr>
<tr>
<td align="left" valign="middle">10</td>
<td align="left" valign="middle">O&#x2019;Connor PJ</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">237</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">25</td>
</tr>
<tr>
<td align="left" valign="middle">11</td>
<td align="left" valign="middle">Sidney S</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">6</td>
<td align="center" valign="middle">231</td>
<td align="center" valign="middle">5</td>
<td align="center" valign="middle">16</td>
<td align="center" valign="middle">25</td>
</tr>
<tr>
<td align="left" valign="middle">12</td>
<td align="left" valign="middle">Vrijhoef HJM</td>
<td align="center" valign="middle">25</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">380</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">7</td>
<td align="center" valign="middle">15</td>
</tr>
<tr>
<td align="left" valign="middle">13</td>
<td align="left" valign="middle">Chubak J</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">380</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">13</td>
<td align="center" valign="middle">21</td>
</tr>
<tr>
<td align="left" valign="middle">14</td>
<td align="left" valign="middle">Kipnis P</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">361</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">14</td>
<td align="center" valign="middle">24</td>
</tr>
<tr>
<td align="left" valign="middle">15</td>
<td align="left" valign="middle">Silverberg MJ</td>
<td align="center" valign="middle">24</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">236</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">20</td>
</tr>
<tr>
<td align="left" valign="middle">16</td>
<td align="left" valign="middle">Anema JR</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">380</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">22</td>
</tr>
<tr>
<td align="left" valign="middle">17</td>
<td align="left" valign="middle">Gould MK</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">380</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">8</td>
<td align="center" valign="middle">17</td>
</tr>
<tr>
<td align="left" valign="middle">18</td>
<td align="left" valign="middle">Weinmann S</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">240</td>
<td align="center" valign="middle">1</td>
<td align="center" valign="middle">10</td>
<td align="center" valign="middle">22</td>
</tr>
<tr>
<td align="left" valign="middle">19</td>
<td align="left" valign="middle">Weisner C</td>
<td align="center" valign="middle">22</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">236</td>
<td align="center" valign="middle">2</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">22</td>
</tr>
<tr>
<td align="left" valign="middle">20</td>
<td align="left" valign="middle">Dublin S</td>
<td align="center" valign="middle">21</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">380</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">12</td>
<td align="center" valign="middle">21</td>
</tr>
</tbody>
</table>
</table-wrap>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption><p>Collaboration network of top 20 most productive authors.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g004.tif"/>
</fig>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption><p>Most highly frequent keywords ranked by counts.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Ranking</th>
<th align="left" valign="top">Keyword</th>
<th align="center" valign="top">Counts</th>
<th align="center" valign="top">Ranking</th>
<th align="left" valign="top">Keyword</th>
<th align="center" valign="top">Counts</th>
<th align="center" valign="top">Ranking</th>
<th align="left" valign="top">Keyword</th>
<th align="center" valign="top">Counts</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1</td>
<td align="left" valign="top">Integrated care</td>
<td align="center" valign="top">1,005</td>
<td align="center" valign="top">33</td>
<td align="left" valign="top">Health policy</td>
<td align="center" valign="top">48</td>
<td align="center" valign="top">64</td>
<td align="left" valign="top">cost-effectiveness</td>
<td align="center" valign="top">28</td>
</tr>
<tr>
<td align="left" valign="top">2</td>
<td align="left" valign="top">Integrative medicine</td>
<td align="center" valign="top">547</td>
<td align="center" valign="top">34</td>
<td align="left" valign="top">Health services</td>
<td align="center" valign="top">48</td>
<td align="center" valign="top">65</td>
<td align="left" valign="top">Mixed methods</td>
<td align="center" valign="top">28</td>
</tr>
<tr>
<td align="left" valign="top">3</td>
<td align="left" valign="top">Primary care</td>
<td align="center" valign="top">349</td>
<td align="center" valign="top">35</td>
<td align="left" valign="top">Public health</td>
<td align="center" valign="top">48</td>
<td align="center" valign="top">66</td>
<td align="left" valign="top">Aged</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">4</td>
<td align="left" valign="top">Mental health</td>
<td align="center" valign="top">167</td>
<td align="center" valign="top">36</td>
<td align="left" valign="top">Qualitative</td>
<td align="center" valign="top">47</td>
<td align="center" valign="top">67</td>
<td align="left" valign="top">CAM</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">5</td>
<td align="left" valign="top">Complementary and alternative medicine</td>
<td align="center" valign="top">137</td>
<td align="center" valign="top">37</td>
<td align="left" valign="top">Alternative medicine</td>
<td align="center" valign="top">46</td>
<td align="center" valign="top">78</td>
<td align="left" valign="top">General practice</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">6</td>
<td align="left" valign="top">Qualitative research</td>
<td align="center" valign="top">131</td>
<td align="center" valign="top">38</td>
<td align="left" valign="top">Pregnancy</td>
<td align="center" valign="top">46</td>
<td align="center" valign="top">69</td>
<td align="left" valign="top">Health information technology</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">7</td>
<td align="left" valign="top">Integration</td>
<td align="center" valign="top">129</td>
<td align="center" valign="top">39</td>
<td align="left" valign="top">Prevention</td>
<td align="center" valign="top">44</td>
<td align="center" valign="top">70</td>
<td align="left" valign="top">Medicaid</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">8</td>
<td align="left" valign="top">Complementary medicine</td>
<td align="center" valign="top">115</td>
<td align="center" valign="top">40</td>
<td align="left" valign="top">Nursing</td>
<td align="center" valign="top">43</td>
<td align="center" valign="top">71</td>
<td align="left" valign="top">Medication adherence</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">9</td>
<td align="left" valign="top">Primary health care</td>
<td align="center" valign="top">115</td>
<td align="center" valign="top">41</td>
<td align="left" valign="top">Mortality</td>
<td align="center" valign="top">42</td>
<td align="center" valign="top">72</td>
<td align="left" valign="top">Patient experience</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">10</td>
<td align="left" valign="top">Quality of life</td>
<td align="center" valign="top">110</td>
<td align="center" valign="top">42</td>
<td align="left" valign="top">Serious mental illness</td>
<td align="center" valign="top">41</td>
<td align="center" valign="top">73</td>
<td align="left" valign="top">Qualitative study</td>
<td align="center" valign="top">27</td>
</tr>
<tr>
<td align="left" valign="top">11</td>
<td align="left" valign="top">Palliative care</td>
<td align="center" valign="top">90</td>
<td align="center" valign="top">43</td>
<td align="left" valign="top">Evaluation</td>
<td align="center" valign="top">40</td>
<td align="center" valign="top">74</td>
<td align="left" valign="top">Asthma</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">13</td>
<td align="left" valign="top">Quality improvement</td>
<td align="center" valign="top">73</td>
<td align="center" valign="top">44</td>
<td align="left" valign="top">Integrated</td>
<td align="center" valign="top">40</td>
<td align="center" valign="top">75</td>
<td align="left" valign="top">Case management</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">14</td>
<td align="left" valign="top">Collaborative care</td>
<td align="center" valign="top">69</td>
<td align="center" valign="top">45</td>
<td align="left" valign="top">Self-management</td>
<td align="center" valign="top">40</td>
<td align="center" valign="top">76</td>
<td align="left" valign="top">Patient safety</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">15</td>
<td align="left" valign="top">Integrated health care</td>
<td align="center" valign="top">64</td>
<td align="center" valign="top">46</td>
<td align="left" valign="top">Medical education</td>
<td align="center" valign="top">39</td>
<td align="center" valign="top">77</td>
<td align="left" valign="top">Physical activity</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">16</td>
<td align="left" valign="top">Quality of care</td>
<td align="center" valign="top">64</td>
<td align="center" valign="top">47</td>
<td align="left" valign="top">Aging</td>
<td align="center" valign="top">36</td>
<td align="center" valign="top">78</td>
<td align="left" valign="top">Risk factors</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">17</td>
<td align="left" valign="top">Chronic Disease</td>
<td align="center" valign="top">63</td>
<td align="center" valign="top">48</td>
<td align="left" valign="top">Elderly</td>
<td align="center" valign="top">36</td>
<td align="center" valign="top">79</td>
<td align="left" valign="top">Spirituality</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">18</td>
<td align="left" valign="top">Complementary therapies</td>
<td align="center" valign="top">63</td>
<td align="center" valign="top">49</td>
<td align="left" valign="top">Health disparities</td>
<td align="center" valign="top">36</td>
<td align="center" valign="top">80</td>
<td align="left" valign="top">Telehealth</td>
<td align="center" valign="top">26</td>
</tr>
<tr>
<td align="left" valign="top">19</td>
<td align="left" valign="top">Behavioral health</td>
<td align="center" valign="top">61</td>
<td align="center" valign="top">50</td>
<td align="left" valign="top">Mental health services</td>
<td align="center" valign="top">36</td>
<td align="center" valign="top">81</td>
<td align="left" valign="top">Chiropractic</td>
<td align="center" valign="top">25</td>
</tr>
<tr>
<td align="left" valign="top">20</td>
<td align="left" valign="top">Care coordination</td>
<td align="center" valign="top">61</td>
<td align="center" valign="top">51</td>
<td align="left" valign="top">Chronic care model</td>
<td align="center" valign="top">35</td>
<td align="center" valign="top">82</td>
<td align="left" valign="top">Health systems</td>
<td align="center" valign="top">25</td>
</tr>
<tr>
<td align="left" valign="top">21</td>
<td align="left" valign="top">Delivery of Health care</td>
<td align="center" valign="top">59</td>
<td align="center" valign="top">52</td>
<td align="left" valign="top">Diabetes mellitus</td>
<td align="center" valign="top">35</td>
<td align="center" valign="top">83</td>
<td align="left" valign="top">Herbal medicine</td>
<td align="center" valign="top">25</td>
</tr>
<tr>
<td align="left" valign="top">22</td>
<td align="left" valign="top">Chronic pain</td>
<td align="center" valign="top">58</td>
<td align="center" valign="top">53</td>
<td align="left" valign="top">Health</td>
<td align="center" valign="top">32</td>
<td align="center" valign="top">84</td>
<td align="left" valign="top">Mental health care</td>
<td align="center" valign="top">25</td>
</tr>
<tr>
<td align="left" valign="top">23</td>
<td align="left" valign="top">Health services research</td>
<td align="center" valign="top">55</td>
<td align="center" valign="top">54</td>
<td align="left" valign="top">Supportive care</td>
<td align="center" valign="top">32</td>
<td align="center" valign="top">85</td>
<td align="left" valign="top">Pain management</td>
<td align="center" valign="top">25</td>
</tr>
<tr>
<td align="left" valign="top">24</td>
<td align="left" valign="top">Older adults</td>
<td align="center" valign="top">52</td>
<td align="center" valign="top">55</td>
<td align="left" valign="top">Traditional Chinese medicine</td>
<td align="center" valign="top">32</td>
<td align="center" valign="top">86</td>
<td align="left" valign="top">Assessment</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">25</td>
<td align="left" valign="top">Patient-centered care</td>
<td align="center" valign="top">52</td>
<td align="center" valign="top">56</td>
<td align="left" valign="top">COPD</td>
<td align="center" valign="top">31</td>
<td align="center" valign="top">87</td>
<td align="left" valign="top">Chronic care</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">26</td>
<td align="left" valign="top">Collaboration</td>
<td align="center" valign="top">51</td>
<td align="center" valign="top">57</td>
<td align="left" valign="top">Healthcare</td>
<td align="center" valign="top">31</td>
<td align="center" valign="top">88</td>
<td align="left" valign="top">Disability</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">27</td>
<td align="left" valign="top">Health care</td>
<td align="center" valign="top">51</td>
<td align="center" valign="top">58</td>
<td align="left" valign="top">Health care reform</td>
<td align="center" valign="top">30</td>
<td align="center" valign="top">89</td>
<td align="left" valign="top">Implementation science</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">28</td>
<td align="left" valign="top">Telemedicine</td>
<td align="center" valign="top">51</td>
<td align="center" valign="top">59</td>
<td align="left" valign="top">Patient-centered medical home</td>
<td align="center" valign="top">30</td>
<td align="center" valign="top">90</td>
<td align="left" valign="top">Integrated healthcare</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">29</td>
<td align="left" valign="top">Health promotion</td>
<td align="center" valign="top">50</td>
<td align="center" valign="top">60</td>
<td align="left" valign="top">Chinese medicine</td>
<td align="center" valign="top">29</td>
<td align="center" valign="top">91</td>
<td align="left" valign="top">Interprofessional education</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">30</td>
<td align="left" valign="top">Older people</td>
<td align="center" valign="top">50</td>
<td align="center" valign="top">61</td>
<td align="left" valign="top">Integrated health care systems</td>
<td align="center" valign="top">29</td>
<td align="center" valign="top">92</td>
<td align="left" valign="top">Long-term care</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">31</td>
<td align="left" valign="top">Rehabilitation</td>
<td align="center" valign="top">49</td>
<td align="center" valign="top">62</td>
<td align="left" valign="top">Intervention</td>
<td align="center" valign="top">29</td>
<td align="center" valign="top">93</td>
<td align="left" valign="top">Prevalence</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">32</td>
<td align="left" valign="top">Electronic health records</td>
<td align="center" valign="top">48</td>
<td align="center" valign="top">63</td>
<td align="left" valign="top">Chemotherapy</td>
<td align="center" valign="top">28</td>
<td align="center" valign="top">94</td>
<td align="left" valign="top">Program evaluation</td>
<td align="center" valign="top">24</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Count, Frequency in 7,501.</p>
</table-wrap-foot>
</table-wrap>
<fig position="float" id="fig5">
<label>Figure 5</label>
<caption><p>Keyword co-occurrence network of the most frequent keywords by the counts.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g005.tif"/>
</fig>
<table-wrap position="float" id="tab4">
<label>Table 4</label>
<caption><p>Keywords for the four clusters.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Cluster</th>
<th align="left" valign="top">Cluster name</th>
<th align="left" valign="top">Author keywords</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">1(Red,36)</td>
<td align="left" valign="top">Integrated care</td>
<td align="left" valign="top">assessment, behavior health, care coordination, chronic care, chronic care model, chronic disease, collaboration, collaborative care, copd, elderly, evaluation, general practice, health care, health disparities, health systems, implementation science, integrated care, integrated health care, integration, interpersonal education, intervention, long-term care, Medicaid, mental health, mental health care, mixed methods, multimorbidity, older people, patient experience, patient-centered home, primary care, qualitative, quality study, quality improvement, quality of care, serious mental illness</td>
</tr>
<tr>
<td align="left" valign="top">2(Green, 26)</td>
<td align="left" valign="top">Depression</td>
<td align="left" valign="top">asthma, aging, aged, case management, cost-effective, diabetes mellitus, disability, electronic health record, health, health information technology, health promotion, health services, healthcare, heart failure, integrated healthcare, medication adherence, nursing, older adults, patient-centered care, prevalence, prevention, rehabilitation, risk factors, self-management, telehealth, telemedicine</td>
</tr>
<tr>
<td align="left" valign="top">3(Blue,19)</td>
<td align="left" valign="top">Integrative medicine</td>
<td align="left" valign="top">alternative medicine, cam, Chinese medicine, chronic pain, complementary and alternative medicine, complementary medicine, complementary therapies, herbal Medicine, integrative medicine, integrative oncology, medical education, pain management, physical activity, quality of life, spirituality, supportive care, traditional Chinese medicine, adherence, chemotherapy</td>
</tr>
<tr>
<td align="left" valign="top">4(Yellow,12)</td>
<td align="left" valign="top">Primary health care</td>
<td align="left" valign="top">delivery of health care, health care reform, health policy, health services research, integrated, integrated health services, mental health services, palliative care, primary health care, program evaluation, public health, qualitative research</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap position="float" id="tab5">
<label>Table 5</label>
<caption><p>Top seven largest clusters ranked by size.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Cluster#</th>
<th align="left" valign="top">Label (LLR)</th>
<th align="center" valign="top">Size</th>
<th align="center" valign="top">Silhouette</th>
<th align="left" valign="top">Top 3 terms (LLR)</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">0</td>
<td align="left" valign="top">Qualitative study</td>
<td align="center" valign="top">129</td>
<td align="center" valign="top">0.862</td>
<td align="left" valign="top">Integrated patient care (2.64), requiring medical care (2.25), noncommunicable diseases (2.25).</td>
</tr>
<tr>
<td align="left" valign="top">1</td>
<td align="left" valign="top">Serious mental illness</td>
<td align="center" valign="top">122</td>
<td align="center" valign="top">0.890</td>
<td align="left" valign="top">Mental health service use (1.43), mental health program (1.32), severe psychotic disorder (1.26).</td>
</tr>
<tr>
<td align="left" valign="top">2</td>
<td align="left" valign="top">Health systems integration</td>
<td align="center" valign="top">119</td>
<td align="center" valign="top">0.845</td>
<td align="left" valign="top">Therapeutic assertive community treatment (2.98), comprehensive integrated control program (2.77), stratification strategies (2.77).</td>
</tr>
<tr>
<td align="left" valign="top">3</td>
<td align="left" valign="top">Integrative medicine</td>
<td align="center" valign="top">104</td>
<td align="center" valign="top">0.928</td>
<td align="left" valign="top">Integrated goal-directed approach (0.67), western model (0.4), oncology clinic (0.4).</td>
</tr>
<tr>
<td align="left" valign="top">4</td>
<td align="left" valign="top">Patient-centered medical home</td>
<td align="center" valign="top">94</td>
<td align="center" valign="top">0.869</td>
<td align="left" valign="top">Patient outcomes research (0.67), providing ward pharmacy service (0.61), patient adherence (0.58).</td>
</tr>
<tr>
<td align="left" valign="top">5</td>
<td align="left" valign="top">Chronic pain</td>
<td align="center" valign="top">55</td>
<td align="center" valign="top">0.921</td>
<td align="left" valign="top">Physical chronic health care need (0.47), chronic somatic diseases (0.43), chronic pain result (0.43).</td>
</tr>
<tr>
<td align="left" valign="top">6</td>
<td align="left" valign="top">Complementary medicine</td>
<td align="center" valign="top">50</td>
<td align="center" valign="top">0.920</td>
<td align="left" valign="top">Teaching yoga (0.72), traditional Chinese medicine (0.66), multidisciplinary care program (0.62).</td>
</tr>
</tbody>
</table>
</table-wrap>
<fig position="float" id="fig6">
<label>Figure 6</label>
<caption><p>Document co-citation network.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g006.tif"/>
</fig>
<table-wrap position="float" id="tab6">
<label>Table 6</label>
<caption><p>Top 10 most frequently cited articles during 2010&#x2013;2020 sorted by count.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Author (year)</th>
<th align="left" valign="top">Journal</th>
<th align="center" valign="top">Count</th>
<th align="center" valign="top">BC</th>
<th align="center" valign="top">Cluster#</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref76">Valentijn et al. (2013)</xref></td>
<td align="left" valign="middle">International Journal of Integrated Care</td>
<td align="center" valign="middle">117</td>
<td align="center" valign="middle">0.13</td>
<td align="center" valign="middle">2</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref42">Kodner and Spreeuwenberg (2002)</xref></td>
<td align="left" valign="middle">International Journal of Integrated Care</td>
<td align="center" valign="middle">90</td>
<td align="center" valign="middle">0</td>
<td align="center" valign="middle">6</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref13">Berwick et al. (2008)</xref></td>
<td align="left" valign="middle">Health Affair</td>
<td align="center" valign="middle">68</td>
<td align="center" valign="middle">0.08</td>
<td align="center" valign="middle">2</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref10">Barnett et al. (2012)</xref></td>
<td align="left" valign="middle">Lancet</td>
<td align="center" valign="middle">65</td>
<td align="center" valign="middle">0.05</td>
<td align="center" valign="middle">0</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref81">Woltmann et al. (2012)</xref></td>
<td align="left" valign="middle">American Journal of Psychiatry</td>
<td align="center" valign="middle">57</td>
<td align="center" valign="middle">0.16</td>
<td align="center" valign="middle">1</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref41">Katon (2010)</xref></td>
<td align="left" valign="middle">New England Journal Medical</td>
<td align="center" valign="middle">55</td>
<td align="center" valign="middle">0.37</td>
<td align="center" valign="middle">4</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref65">Singer et al. (2011)</xref></td>
<td align="left" valign="middle">Medical Care Research Review</td>
<td align="center" valign="middle">53</td>
<td align="center" valign="middle">0.13</td>
<td align="center" valign="middle">0</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref4">Archer (2012)</xref></td>
<td align="left" valign="middle">Cochrane Database of Systematic Reviews</td>
<td align="center" valign="middle">52</td>
<td align="center" valign="middle">0.06</td>
<td align="center" valign="middle">1</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref9">Barnes et al. (2008)</xref></td>
<td align="left" valign="middle">National Health Statistics Reports</td>
<td align="center" valign="middle">45</td>
<td align="center" valign="middle">0.04</td>
<td align="center" valign="middle">3</td>
</tr>
<tr>
<td align="left" valign="top"><xref ref-type="bibr" rid="ref36">Horneber et al. (2012)</xref></td>
<td align="left" valign="middle">Integrative cancer therapies</td>
<td align="center" valign="middle">43</td>
<td align="center" valign="middle">0.01</td>
<td align="center" valign="middle">6</td>
</tr>
</tbody>
</table>
</table-wrap>
<fig position="float" id="fig7">
<label>Figure 7</label>
<caption><p>Document co-citation analysis clusters timeline visualization.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g007.tif"/>
</fig>
<fig position="float" id="fig8">
<label>Figure 8</label>
<caption><p>Flowchart of this paper.</p></caption>
<graphic xlink:href="fpsyg-14-1095616-g008.tif"/>
</fig>
</sec>
</sec>
<sec sec-type="results" id="sec13">
<label>3.</label>
<title>Results</title>
<sec id="sec14">
<label>3.1.</label>
<title>Chronological articles</title>
<p><xref rid="fig1" ref-type="fig">Figure 1</xref> presents the number of related papers published from 2010 to 2020. The number of publications on IC was rising in general. However, the annual growth rate of related literature varies greatly in this field; the highest literature volume is five times larger than the lowest (2012 and 2019).</p>
</sec>
<sec id="sec15">
<label>3.2.</label>
<title>Disciplinary areas distribution</title>
<p><xref rid="fig2" ref-type="fig">Figure 2</xref> shows the distribution of the disciplinary areas on IC. The total number of documents in the top 10 disciplines is 6,886, accounting for 91.107%, namely, health care science services (1,559, 20.627%), public environmental occupational health (1,166, 15.427%), health policy services (1,053, 13.932%), general and internal medicine (832, 11.008%), integrative complementary medicine (638, 8.441%), psychiatry (498, 6.589%), oncology (351, 4.644%), nursing (318, 4.207%), pharmacology pharmacy (259, 3.427%) and pediatrics (212, 2.805%).</p>
</sec>
<sec id="sec16">
<label>3.3.</label>
<title>International productivity and collaboration analysis</title>
<p><xref rid="tab1" ref-type="table">Table 1</xref> shows the top 20 countries ranked by the percentage of publications. The United States was the most productive country, with a total of 4,112, accounting for 54.82%, and the BC is 0.45, followed by the United Kingdom (656, 8.75%, 0.16) and Australia (501, 6.68%, 0.15). In terms of regions, Europe has 11 countries, accounting for 55%; Asia has 4 (20%), America has 3 (15%), and Oceania and Africa have 1 each (5% respectively). Combining <xref rid="tab1" ref-type="table">Table 1</xref> and <xref rid="fig3" ref-type="fig">Figure 3</xref>, the United States, with the largest number of publications and the highest BC, is at the center of the national cooperation network. In addition, countries such as the United Kingdom, Australia and the Netherlands have close cooperation with other countries, and they play important roles in the development of global IC. China has published 312 articles (4.16%) and ranks first in Asia, but the BC is only 0.08. showing that China lacks international cooperation with other countries on IC.</p>
</sec>
<sec id="sec17">
<label>3.4.</label>
<title>Author productivity and collaboration</title>
<p>The BiblioMetrix Tool Package in R development software was used to analyze all the authors in 7,501 studies, with a total of 31,958 authors. The number of authors per paper was 4.26, and the number of authors with one paper was 25,411, accounting for 79.5%.</p>
<p>According to Price&#x2019;s Law, authors of more than or equal to six articles (the core author), a total of 598 authors, and only the top 20 prolific authors are selected in this study. Then, software to calculate multiple indicators such as the number of essays, BC, CC, DC, h-index and g-index for the top 20 authors; multi-dimensional judgment of the author&#x2019;s influences is developed (<xref ref-type="bibr" rid="ref35">Hirsch, 2005</xref>; <xref ref-type="bibr" rid="ref31">Egge, 2006</xref>). As shown in <xref rid="tab2" ref-type="table">Table 2</xref>, Ben-Arye E has published the most articles, with a total of 60 articles, followed by Schiff E and Jacobsen SJ.</p>
<p><xref rid="fig4" ref-type="fig">Figure 4</xref> shows the collaborative network of the top 20 productive authors. The nodes represent 20 core authors; The circle means BC is 0, the diamond means BC is 2, the upward-pointing triangle means BC is 6, the box means BC is 7, and the downward-pointing triangle means that BC is 14. Combining <xref rid="tab2" ref-type="table">Table 2</xref> and <xref rid="fig4" ref-type="fig">Figure 4</xref>, although Quesenberry CP does not have the largest number of articles, the BC is the largest, so he is at the center of the network. In addition, Quesenberry CP, Jacobsen SJ, Sidney S, and Karter AJ formed an academic group, who are from the same institution (Kaiser Permanente, Oakland, California, United States). The other academic group was formed by Ben-Arye E, Schiff E, and Samuels N. However, no cooperation occurred between the two groups. In addition, six authors did not cooperate with other authors.</p>
</sec>
<sec id="sec18">
<label>3.5.</label>
<title>Research hotspots</title>
<p>Noun items can be used to detect research hotspots in the field (<xref ref-type="bibr" rid="ref22">Chiu and Ho, 2007</xref>). Keywords are nouns or phrases that reflect the core content of a publication (<xref ref-type="bibr" rid="ref21">Chen et al., 2018</xref>), and high-frequency words represent the research hotspots (<xref ref-type="bibr" rid="ref83">Xie et al., 2008</xref>). BibExcel was used to extract all the keywords in the literature, and after merging and removing duplication, a total of 12,449 keywords were obtained. Among them, 9,347 keywords appeared once, accounting for 75.08%. According to Price&#x2019;s Law, keywords with a frequency greater than or equal to 24 are considered high-frequency keywords. The top ten keywords by frequency are &#x201C;IC&#x201D; (1005), &#x201C;integrative medicine&#x201D; (547), &#x201C;primary care&#x201D; (349), &#x201C;mental health&#x201D; (167), &#x201C;complementary and alternative medicine&#x201D; (137), &#x201C;qualitative research&#x201D; (131), &#x201C;integration&#x201D; (129), &#x201C;complementary medicine&#x201D; (115), &#x201C;primary health care&#x201D; (115), and &#x201C;quality of life&#x201D; (110), as shown in <xref rid="tab3" ref-type="table">Table 3</xref>.</p>
<p>VOSviewer was used to draw map keyword co-occurrence networks, as shown in <xref rid="fig5" ref-type="fig">Figure 5</xref>.</p>
<p>A total of 4 clusters and 1,144 lines were formed based on the Linlog/Modularity algorithm. These 4 clusters represent the research hotspots on IC in the past decade. Using the largest node in each research hotspot as the cluster name, Cluster 1 (Red, IC) is the largest category and contains 36 keywords. Cluster 2 (Green, Depression) contains 26, Cluster 3 (Blue, Integrative medicine) contains 19, and Cluster 4 (Yellow, Primary health care) contains 12, as shown in <xref rid="tab4" ref-type="table">Table 4</xref>.</p>
<p>The keywords in the four clusters reveal the characteristics involved in the development of integrated healthcare. &#x2460; IC should be value-based and health-centered, providing health services across the life cycle and achieving optimal health outcomes with limited resources. &#x2461; Service targets should include the whole population, not just special people who need long-term care.&#x2462; Focus more on health promotion and disease prevention, and to promote the integration of public health services and clinical care. &#x2463; Pay attention to self-management and be the first responsible person for own health. &#x2464; Attach importance to the role of complementary medicine in IC. &#x2465; IC strategies need to be designed and developed taking account of the particular local realities.&#x2466; Promote incentive reform and give full play to the regulatory role of health insurance leverage to promote the development of IC. &#x2467; Use digital technology to empower IC. &#x2468; Establish effective governance, evaluation and accountability mechanisms.</p>
</sec>
<sec id="sec19">
<label>3.6.</label>
<title>Research trend</title>
<sec id="sec20">
<label>3.6.1.</label>
<title>Reference co-citation analysis</title>
<p>Document co-citation analysis is often used to detect historical evolution and research trends in the field (<xref ref-type="bibr" rid="ref20">Chen et al., 2012</xref>). A total of 210,081 references are attached to 7,501 articles. CiteSpace was used to analyze these references. A total of 850 nodes and 3,176 lines were mapped. To highlight the role of key documents, the top 50 cited documents per year were selected as the analysis object.</p>
<p>Based on the log-likelihood ratio algorithm (<xref ref-type="bibr" rid="ref33">Fang et al., 2018</xref>), and according to the silhouette value (the closer the value is to 1, the more reliable the clustering), clusters less than 0.7 were filtered out, finally forming seven clusters. The top three clusters were Cluster 0 (qualitative study), Cluster 1 (serious mental illness), and Cluster 2 (health systems integration), as shown in <xref rid="fig6" ref-type="fig">Figure 6</xref> and listed in <xref rid="tab5" ref-type="table">Table 5</xref>.</p>
</sec>
<sec id="sec21">
<label>3.6.2.</label>
<title>Highly cited articles analysis</title>
<p>Cited references have made revolutionary contributions to the entire research field. Therefore, co-citation analysis of highly cited references is helpful to detect the research foundation in the field (<xref ref-type="bibr" rid="ref37">Hou et al., 2018</xref>). The largest node in each cluster in <xref rid="fig6" ref-type="fig">Figure 6</xref> can be observed, and <xref rid="tab6" ref-type="table">Table 6</xref> lists the top 10 cited references according to their citation frequency and their categories.</p>
<p>As shown in <xref rid="tab7" ref-type="table">Table 7</xref>, there is little stable understanding of IC meant, but all emphasize that IC guiding principle is person-centered, the core purpose is to improve the efficiency of the health system and ensures people receive a continuum health services. Moreover, coordination among stakeholders is critical to the accomplishment of goals. In general, the forms of IC are complex and multidimensional. The scope of integration includes organizational, services, funding, information, and regulatory. In terms of service recipients, the disadvantaged are the ones who get the most attention, IC can generate significant health benefits for them.</p>
<table-wrap position="float" id="tab7">
<label>Table 7</label>
<caption><p>Viewpoints of the top 10 most frequently cited articles.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Author</th>
<th align="left" valign="top">Title</th>
<th align="left" valign="top">Viewpoint</th>
<th align="left" valign="top">Dimensions of IC</th>
<th align="left" valign="top">Core elements</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Valentijn PP</td>
<td align="left" valign="top">Understanding integrated care: a comprehensive conceptual framework based on the integrative functions of primary care</td>
<td align="left" valign="top">Integration has to be pursued at different levels within a system based on specific contexts to provide continuous, comprehensive and coordinated service to individuals and populations.</td>
<td align="left" valign="top">Micro (clinical); meso (professional-and organizational); macro (system); functional (nancial, management and information systems); normative (shared mission, vision, values and culture)</td>
<td align="left" valign="top">Person-focused, comprehensive care, inter-sectorial partnerships, coordinate and support accountability and decision-making, common frame</td>
</tr>
<tr>
<td align="left" valign="top">Kodner DL</td>
<td align="left" valign="top">Integrated care: meaning, logic, applications, and implications--a discussion paper</td>
<td align="left" valign="top">There are varying degrees of completeness, comprehensiveness and formality in IC, the use of strategies would depend on the characteristics of the patient population and the specific challenges.</td>
<td align="left" valign="top">Funding, administrative, organization, service, clinical</td>
<td align="left" valign="top">Patient-oriented, connectivity, alignment and collaboration, cost-effectiveness.</td>
</tr>
<tr>
<td align="left" valign="top">Berwick DM</td>
<td align="left" valign="top">The Triple Aim: Care, Health, And Cost</td>
<td align="left" valign="top">Specifying a population of concern, policy constraints, integrator are prerequisites for improving the individual experience of care, improving the health of populations, and reducing the <italic>per capita</italic> costs of care for populations.</td>
<td align="left" valign="top">Macro system, financial, organization, service, clinical</td>
<td align="left" valign="top">Patients need, shared plans, coordinating care, efficient and equitable, reduction and control costs.</td>
</tr>
<tr>
<td align="left" valign="top">Barnett K</td>
<td align="left" valign="top">Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study</td>
<td align="left" valign="top">For most multimorbid patients, a generalist clinicians to provide personalized, comprehensive continuity of care is needed, especially in socio-economically deprived areas.</td>
<td align="left" valign="top">Service, clinical</td>
<td align="left" valign="top">Personalized, comprehensive</td>
</tr>
<tr>
<td align="left" valign="top">Woltmann E</td>
<td align="left" valign="top">Comparative effectiveness of collaborative chronic care models for mental health conditions across primary, specialty, and behavioral health care settings: systematic review and meta-analysis</td>
<td align="left" valign="top">Collaborative chronic care models can improve outcomes for individuals with mental disorders.</td>
<td align="left" valign="top">Service, clinical, information</td>
<td align="left" valign="top">Collaborative, combined modality therapy, continuity care, reduction and control costs.</td>
</tr>
<tr>
<td align="left" valign="top">Katon WJ</td>
<td align="left" valign="top">Collaborative Care for Patients with Depression and Chronic Illnesses</td>
<td align="left" valign="top">Coordinated care management of multiple conditions improves medical outcomes and depression for patients with depression and chronic illnesses.</td>
<td align="left" valign="top">Clinical</td>
<td align="left" valign="top">Coordinate, individualized treatment, treat-to-target</td>
</tr>
<tr>
<td align="left" valign="top">Singer SJ</td>
<td align="left" valign="top">Defining and measuring integrated patient care: promoting the next frontier in health care delivery</td>
<td align="left" valign="top">The challenge in delivering integrated is to provide optimal amounts of both coordination and patient centeredness.</td>
<td align="left" valign="top">system, organization, Service, clinical</td>
<td align="left" valign="top">Coordination, continuous, Patient centeredness</td>
</tr>
<tr>
<td align="left" valign="top">Archer J</td>
<td align="left" valign="top">Collaborative care for depression and anxiety problems.</td>
<td align="left" valign="top">Collaborative care is associated with significant improvement in depression and anxiety outcomes compared with usual care.</td>
<td align="left" valign="top">Service, clinical</td>
<td align="left" valign="top">Collaborative, reduce burden</td>
</tr>
<tr>
<td align="left" valign="top">Barnes PM</td>
<td align="left" valign="top">Complementary and alternative medicine use among adults and children: United States, 2007</td>
<td align="left" valign="top">CAM purports to prevent or treat disease, the use of CMA by children is significantly lower than adults, and adults mainly use CAM for pain relief.</td>
<td align="left" valign="top">Service, clinical</td>
<td align="left" valign="top">Prevent illness, relief pain</td>
</tr>
<tr>
<td align="left" valign="top">Horneber M</td>
<td align="left" valign="top">How Many Cancer Patients Use Complementary and Alternative Medicine</td>
<td align="left" valign="top">Patients use CMA as a coping strategy to treat disease, on average, half of cancer patients use CAM, and it needs for clear strategies to deal with this prevalent health-related behavior.</td>
<td align="left" valign="top">Clinical</td>
<td align="left" valign="top">Frequency and patterns</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec22">
<label>3.6.3.</label>
<title>Cluster timeline visualization</title>
<p>To further clarify the historical evolution of research hotspots in the IC field, the timeline visualization was mapped based on 210,081 references. In <xref rid="fig7" ref-type="fig">Figure 7</xref>, references are shown in the form of circles whose thickness indicates the number of citations within the time slice. The citation tree-ring color represents the citation time, and red indicates that the cited reference has a high BC value. <xref rid="fig7" ref-type="fig">Figure 7</xref> shows the internal and inter-relationship of the largest 7 clusters. The first cluster to emerge was Cluster3 (integrative medicine), which outlined the relevance of complex systems theory as an approach to health outcomes research in the context of integrative medicine. This theory recognizes that health outcomes are influenced by various complex and interconnected factors, including biological, psychological, social, and environmental factors. Cluster4 (patient-centered medical home), which focused on depressed older adults in primary care settings. However, these two research hotspots have not gained much attention in recent years. Although Cluster0 (qualitative study) appeared later, it gathered many red nodes from 2010 to 2018, implying that many highly cited references emerged in that period. Cluster6 (complementary medicine) also features several research hotspots in recent years, some of the main hotspots include depression, non-infectious diseases, chronic pain, multidisciplinary care planning, and mind&#x2013;body practices such as meditation and yoga.</p>
</sec>
</sec>
</sec>
<sec sec-type="discussions" id="sec23">
<label>4.</label>
<title>Discussion</title>
<p>We used various bibliometric tools to provide a comprehensive bibliographic review of IC from the Web of Science (WOS) from the period 2010&#x2013;2020. Through approaches such as keyword frequency analysis, co-authorship analysis, reference co-citation network analysis, and highly cited articles analysis, we demonstrated the focus, prospects, and challenges of IC research.</p>
<sec id="sec24">
<label>4.1.</label>
<title>Trends of interest and disciplinary distribution in IC research</title>
<p>Over the past 10&#x2009;years, although the IC field has received increasing attention, the degree of attention has been gradually decreasing every year (<xref rid="fig1" ref-type="fig">Figure 1</xref>). This could be attributed to various factors, and one possible reason is that it has become more widespread, thus the initial novelty is fading and people are shifting their attention to other medical issues and priorities. While the attention given to IC may be decreasing, it is important to recognize its value and potential in improving healthcare outcomes. In terms of disciplinary area distribution (<xref rid="fig2" ref-type="fig">Figure 2</xref>), IC is widely distributed in multiple fields, such as health care sciences services, public environmental occupational health, health policy services, general and internal medicine, psychiatry, oncology, nursing, pharmacy and pediatrics, reflecting that the breadth and depth of IC applications are constantly expanding. The wide distribution of IC in various fields presents a unique opportunity for collaboration and knowledge exchange. For instance, healthcare professionals from different fields can share their insights and experiences in implementing IC in their respective fields, thus enhancing the development and delivery of IC services.</p>
</sec>
<sec id="sec25">
<label>4.2.</label>
<title>Dominance of developed countries in IC research and importance of tailoring IC strategies to specific settings</title>
<p>In terms of the number of publications and the BC value (<xref rid="fig3" ref-type="fig">Figure 3</xref>), the top three countries were the United States, the United Kingdom and Australia. Combined with <xref rid="tab1" ref-type="table">Table 1</xref>, the proportion of developed countries&#x2019; publications is much higher than that of developing countries. Many high-income countries in Europe and America have adopted IC to address the health needs of aging populations and rising rates of chronic and multiple morbidities (<xref ref-type="bibr" rid="ref56">Point, 2011</xref>; <xref ref-type="bibr" rid="ref45">Kringos and Klazinga, 2014</xref>). For instance, IC has been available in the United States for 76&#x2009;years, since Kaiser Permanente began offering the first IC insurance plan in 1945 (<xref ref-type="bibr" rid="ref24">Craig et al., 1999</xref>; <xref ref-type="bibr" rid="ref46">Laugesen and France, 2014</xref>). The English National Health Service has experimented with the integration of care since the 1990s and established 16 IC pilot programs with a range of objectives in 2008. To some extent, there is no one model of IC strategy that can fit all countries (<xref ref-type="bibr" rid="ref8">Averill et al., 2010</xref>; <xref ref-type="bibr" rid="ref52">Maruthappu et al., 2015</xref>), the design of specific measures should take into account the local culture, socioeconomic development, governance, and service recipients (<xref ref-type="bibr" rid="ref6">Atun et al., 2010</xref>; <xref ref-type="bibr" rid="ref67">Stadnick et al., 2019</xref>). However, even if different countries have different paths to achieve IC, there is a need to develop a uniform framework of principles. WHO has developed a common set of principles of IC that are comprehensive, equitable, sustainable, holistic, preventive, empowering, respectful, collaborative, co-produced, endowed with rights and responsibilities, governed through shared accountability, evidence-informed, led by whole-systems thinking and Ethical (<xref ref-type="bibr" rid="ref82">World Health Organization, 2015</xref>). Furthermore, value-based healthcare has become an international consensus (<xref ref-type="bibr" rid="ref26">Daniels et al., 2022</xref>; <xref ref-type="bibr" rid="ref27">de Vasconcelos et al., 2022</xref>; <xref ref-type="bibr" rid="ref44">Kokko, 2022</xref>). While WHO provides a thorough and widely-accepted IC framework, but there&#x2019;s potential for further refinement, context-specific adaptation, and inclusion of new concepts as healthcare evolves. The principles&#x2019; effectiveness hinges on their practical implementation in real-world healthcare scenarios. Thus, countries should collaborate to enhance the value objectives, principles, and key elements of IC, and explore paths of integration tailored to each nation&#x2019;s characteristics within the theoretical framework.</p>
</sec>
<sec id="sec26">
<label>4.3.</label>
<title>Co-authorship networks and the need for improved collaboration in IC research</title>
<p>Bibliometrix R-tool was used to analyze the top 20 most productive authors (<xref rid="tab2" ref-type="table">Table 2</xref>), Ucinet was used to manage the co-author matrix. Ben-Arye E had the most publications but a BC of 0 and was not placed in the control position in the network information; the author formed a triangular cooperation network with Schiff E and Jacobsen SJ. On the other hand, although Quesenberry CP only published 31 articles, he collaborated with several authors to form a large cooperative network. In addition, he had the largest BC and was at the center of the network, meaning that he acts as a bridge for information in the network. The analysis reveals that effective cooperation among authors is lacking, despite the formation of several scholar groups. This finding indicates a need for greater collaboration within the academic community, by promoting more effective collaboration, including theoretical exchanges and practical sharing, researchers can pool their expertise and resources to accelerate advancements in the field.</p>
</sec>
<sec id="sec27">
<label>4.4.</label>
<title>Interdisciplinary collaboration and trends in IC research</title>
<p>From BibExcel statistics, 93 high frequency keywords were extracted (<xref rid="tab3" ref-type="table">Table 3</xref>). In addition to &#x201C;integrated care&#x201D; and &#x201C;integrated health care,&#x201D; the hot keywords included &#x201C;primary care,&#x201D; &#x201C;mental health,&#x201D; &#x201C;complementary and alternative medicine,&#x201D; &#x201C;palliative care,&#x201D; and &#x201C;self-management.&#x201D; By using the knowledge mapping tool VOSviewer to visualize keyword co-occurrence analysis (<xref rid="fig6" ref-type="fig">Figure 6</xref>), four further hotspot clusters were generated (<xref rid="tab4" ref-type="table">Table 4</xref>). These results indicate that IC is not limited to the clinical field, but has broken down disciplinary barriers and encourages interdisciplinary cooperation, thus health systems should provide health services that integrate prevention, diagnosis, treatment, rehabilitation, and palliative care to cover the health needs of the region&#x2019;s residents. In addition, to meet the needs and preferences of the population, individuals should be seen as active participants in health management and take responsibility for their own health (<xref ref-type="bibr" rid="ref58">Rittenhouse and Shortell, 2009</xref>; <xref ref-type="bibr" rid="ref65">Singer et al., 2011</xref>).</p>
<p>Science knowledge mapping was used to analyze reference co-citation, highly cited articles and timelines and detect and research historical evolution and trends. With the support of CiteSpace, 210,081 references were analyzed. According to document co-citation analysis, seven clusters were generated (<xref rid="fig6" ref-type="fig">Figure 6</xref>), namely, Cluster 0 (qualitative study), Cluster 1 (serious mental illness), Cluster 2 (health systems integration), Cluster 3 (integrative medicine), Cluster 4 (patient-centered medical home), Cluster 5 (chronic pain) and Cluster 6 (complementary medicine). We observed that the prominence of Cluster 0 (qualitative study) as the main cluster in keyword analysis could be due to its vital role in integrated healthcare research, where it is often used to investigate patient experiences, healthcare behaviors, and healthcare decision-making. Furthermore, we noted that the earliest research clusters are Cluster 3 (integrative medicine) and Cluster 4 (patient-centered medical home), which are related to the history of integrated healthcare development, from advocacy IHCD to encourage health systems to embrace PCIC approach to organizing health services. Notably, &#x201C;complementary medicine&#x201D; has become a hotspot in recent years, especially with the increasing prevalence of cancer, chronic diseases and mental illnesses; integration of complementary and western medicine can improve the quality of life of patients (<xref ref-type="bibr" rid="ref54">Mongiovi et al., 2016</xref>; <xref ref-type="bibr" rid="ref80">West, 2018</xref>; <xref ref-type="bibr" rid="ref60">Saeed et al., 2019</xref>; <xref ref-type="bibr" rid="ref38">H&#x00FC;bner, 2020</xref>). In addition, traditional Chinese medicine plays a positive role in the treatment of COVID-19 (<xref ref-type="bibr" rid="ref57">Ren, 2020</xref>; <xref ref-type="bibr" rid="ref84">Zhang et al., 2020</xref>). Thus, complementary medicine will continue to be a focus in the future, however, it should be noted that the use of CAMs in clinical practice needs to assess the effectiveness, and safety of CAM (<xref ref-type="bibr" rid="ref55">Paoloni et al., 2022</xref>).</p>
</sec>
<sec id="sec28">
<label>4.5.</label>
<title>Key contributors and publications in the IC field</title>
<p>Among the top 10 frequently cited articles, four were concerned with integrated or integrative care, and the other articles were about pediatrics, collaborative care, complementary and alternative medicine, highlighting the interdisciplinary nature of IC. These highly cited articles were contributed by influential authors such as Valentijn PP, Koebnick C, Berwick DM, Barnett K and Woltmann E, who have made significant contributions to the development and advancement of the field, enhancing our knowledge and understanding of IC. The sources of articles with more citations and higher influential factors included the Lancet, the New England Journal of Medicine, the International Journal of IC and the American Journal of Psychiatry. High-quality periodicals have a positive effect on the development of the subject. These journals provide a platform for disseminating research findings and facilitating collaboration among researchers and healthcare professionals, contributing positively to the development of the field.</p>
</sec>
<sec id="sec29">
<label>4.6.</label>
<title>Challenges and solutions in advancing IC</title>
<p>The advancement of IC faces different challenges, especially in complex and changing external environments. Firstly, theory and practice are not in sync. Person-centered care is often defined as the core of IC, so people-centered care needs people-centered research, IC strategies should be based on co-creation with patients or citizens in ways that involve, engage and empower them, but a chasm remains between theory and practice (<xref ref-type="bibr" rid="ref77">van der Vlegel-Brouwer et al., 2020</xref>). In addition, inter-organizational collaboration is the key to delivering IC. However, many barriers related to administration and regulation, resources and funding hinder the collaboration (<xref ref-type="bibr" rid="ref3">Andersson et al., 2011</xref>; <xref ref-type="bibr" rid="ref43">Koebnick et al., 2012</xref>; <xref ref-type="bibr" rid="ref14">Boothroyd et al., 2015</xref>; <xref ref-type="bibr" rid="ref7">Auschra, 2018</xref>; <xref ref-type="bibr" rid="ref64">Simpson et al., 2023</xref>), Therefore, relevant authorities should take action to overcome such barriers. For example, China has proposed the &#x201C;County Medical Alliance,&#x201D; which integrates the medical service network at the county, township and village levels in six areas: administration, personnel, finance, services, assessment and supply of medicine and equipment to provide a full, continuous and coordinated service for service recipients. Countries or regions with health service systems similar to those of China can learn from the &#x201C;County Medical Alliance&#x201D; model to promote the development of IC. Notably, financial incentives are potentially powerful tools to stimulate IC (<xref ref-type="bibr" rid="ref8">Averill et al., 2010</xref>; <xref ref-type="bibr" rid="ref74">Tsiachristas, 2016</xref>), but separate payment mechanism can block effective integration (<xref ref-type="bibr" rid="ref69">Struckmann et al., 2017</xref>), moreover, each payment method has a certain negative incentive effect, so mixed payment should be adopted to support more effective and efficient IC system (<xref ref-type="bibr" rid="ref12">Berenson and Rice, 2015</xref>; <xref ref-type="bibr" rid="ref68">Stokes et al., 2018</xref>). Furthermore, silos of data collection on a cross-institutional level have created a fragmentation of electronic medical records in many countries, potentially hindering continuity of IC and resulting in clinical, and administrative inefficiencies (<xref ref-type="bibr" rid="ref17">Bradley et al., 2017</xref>; <xref ref-type="bibr" rid="ref53">Meinert et al., 2019</xref>; <xref ref-type="bibr" rid="ref32">Eh et al., 2020</xref>). Governments should fully recognize the great value of medical data, strengthen information systems and promote legal and compliant medical data sharing.</p>
</sec>
</sec>
<sec id="sec30">
<label>5.</label>
<title>Study limitations</title>
<p>The present study had several limitations that need to be mentioned. Firstly, we only focused on articles that have been published in WOSCC and excluded non-English articles or neglected other forms of publication (e.g., books, web pages, and policy documents), which might cause the data obtained to be not comprehensive enough. Additionally, although bibliometrics could provide a valuable mix of information to reflect the current status and research hotspots of the IC domain, it cannot reveal the overall situation in the field, especially when other methods, such as the Latent Dirichlet Allocation model, which can be used for qualitative examination, are ignored. Therefore, Future research could expand our study&#x2019;s findings by including non-English publications and various formats, using additional bibliometric tools like the Latent Dirichlet Allocation model, focusing on the application of identified IC principles and models in diverse healthcare settings, and integrating qualitative research methods for a more comprehensive understanding of the research landscape, emerging themes, and trends.</p>
</sec>
<sec sec-type="conclusions" id="sec31">
<label>6.</label>
<title>Conclusion</title>
<p>In conclusion, the global field of IC has expanded and achieved remarkable results in the last 10&#x2009;years. Developed countries pay more attention to the development of IC than do developing countries, and minimal cooperation occurs among authors and institutions. In addition, results indicated four hotspot clusters, namely, IC, depression, integrative medicine and primary health care. Combined with cluster timeline visualization, complementary medicine has become a hotspot in recent years and will continue to be a focus. Furthermore, there are still many challenges and barriers to IC to achieve person-centered care, these include, but are not limited to resources fragmentation, efficient collaboration difficulties between different levels of health institutions, insufficient financial incentives, inadequate self-management in health, and poor information sharing. So international collaboration should be further strengthened to promote the development of integrated healthcare with value co-creation and model innovation. These findings will help scholars better identify new perspectives for future research.</p>
</sec>
<sec id="sec32">
<title>Author contributions</title>
<p>DG, HL, DS, and YC designed the study. DG, CZ, and XC performed the data analyses. DG, CZ, GG, and XC wrote the initial draft of the paper. All authors contributed to the article and approved the submitted version.</p>
</sec>
<sec sec-type="funding-information" id="sec34">
<title>Funding</title>
<p>This work was supported by the National Natural Science Foundation of China (Support batch number: 71974066) and &#x201C;Double First-class Construction Project of Liberal Arts in Huazhong University of Science and Technology&#x201D; (Think Tank of Rural Health Service Policy and Management).</p>
</sec>
<sec sec-type="COI-statement" id="sec35">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="sec100" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</body>
<back>
<ack>
<p>The authors would like to thank the National Natural Science Foundation of China and Huazhong University of Science and Technology for funding this research.</p>
</ack>
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