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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychol.</journal-id>
<journal-title>Frontiers in Psychology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychol.</abbrev-journal-title>
<issn pub-type="epub">1664-1078</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyg.2021.754115</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychology</subject>
<subj-group>
<subject>Systematic Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Resilience Programs for Children and Adolescents: A Systematic Review and Meta-Analysis</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Pinto</surname> <given-names>Tatiana Matheus</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1384487/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Laurence</surname> <given-names>Paulo Guirro</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/474872/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Macedo</surname> <given-names>Cristiane Rufino</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1546162/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Macedo</surname> <given-names>Elizeu Coutinho</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/164698/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Social and Cognitive Neuroscience Laboratory and Developmental Disorders Program, Center for Health and Biological Sciences, Mackenzie Presbyterian University</institution>, <addr-line>S&#x00E3;o Paulo</addr-line>, <country>Brazil</country></aff>
<aff id="aff2"><sup>2</sup><institution>Brazilian Cochrane Center, Escola Paulista de Medicina, Universidade Federal de S&#x00E3;o Paulo</institution>, <addr-line>S&#x00E3;o Paulo</addr-line>, <country>Brazil</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: David Pineda, Miguel Hern&#x00E1;ndez University of Elche, Spain</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Hugo Borges Sarmento, University of Coimbra, Portugal; Steve Schwartz, IndividuALLytics, United States</p></fn>
<corresp id="c001">&#x002A;Correspondence: Tatiana Matheus Pinto, <email>tatiana.matheus@outlook.com</email></corresp>
<fn fn-type="other" id="fn004"><p>This article was submitted to Psychology for Clinical Settings, a section of the journal Frontiers in Psychology</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>22</day>
<month>11</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="collection">
<year>2021</year>
</pub-date>
<volume>12</volume>
<elocation-id>754115</elocation-id>
<history>
<date date-type="received">
<day>05</day>
<month>08</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>28</day>
<month>10</month>
<year>2021</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2021 Pinto, Laurence, Macedo and Macedo.</copyright-statement>
<copyright-year>2021</copyright-year>
<copyright-holder>Pinto, Laurence, Macedo and Macedo</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>Resilience may be defined as the ability to recover and adapt to adverse situations. Given that resilience involves cognitive and behavioral aspects, it could be promoted based on strategies that favor them, especially during childhood and adolescence. As a result, several resilience-focused programs have been developed and studied. This systematic review of Randomized Controlled Trials (RCTs) aimed to assess resilience-focused programs for children (&#x003C;12 years old) and adolescents (12&#x2013;22 years old) compared to active (treatment as usual, other program modalities, and educational curriculum at school) or inactive (waiting list, no treatment) control groups. We performed a systematic review of meta-analyses of RCTs. The following databases were searched: Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, and PsycINFO. Two authors independently selected the studies, extracted the data, and assessed the studies&#x2019; risk of bias. Meta-analyses of random effects were conducted to calculate the standard mean differences (SMD) and 95% confidence interval (CI) of program effectiveness. Of the 17 RCTs that met the inclusion criteria, 13 provided sufficient data to assess the effectiveness of the programs after their implementation. Meta-analyses indicated overall effectiveness of the programs in promoting resilience (SMD = 0.48, 95% CI [0.15, 0.81], <italic>p</italic> = 0.0077). The subgroup analysis indicated effectiveness only among adolescents&#x2019; resilience (SMD = 0.48, 95% CI [0.08, 0.88], <italic>p</italic> = 0.02). The follow-up analysis also indicated evidence of continuation of results within a period of up to 6 months up (SMD = 0.12, 95% CI [&#x2212;0.44, 0.69], <italic>p</italic> = 0.02). These results indicated the effectiveness of promoting resilience, especially in adolescents, and its continuation in follow-up analyses. These findings are promising in the field of resilience programs; however, further studies are necessary to analyze the different possible characteristics of programs and their results.</p>
<p><bold>Clinical Trial Registration:</bold> [<ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020179874">https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020179874</ext-link>], [CRD42020179874].</p>
</abstract>
<kwd-group>
<kwd>resilience</kwd>
<kwd>program</kwd>
<kwd>children</kwd>
<kwd>adolescents</kwd>
<kwd>systematic review</kwd>
</kwd-group>
<counts>
<fig-count count="7"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="43"/>
<page-count count="13"/>
<word-count count="8455"/>
</counts>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="S1">
<title>Introduction</title>
<p>In a constant changing world where people need to adapt and deal with new challenges daily, resilience is extremely important, as resilient individuals adapt better to life challenges and have higher levels of functionality and quality of life (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>). The American Psychological Association (APA) defines resilience as the ability to recover and adapt to situations of adversity, trauma, threats, or sources of stress. Being resilient, however, does not necessarily mean that individuals will not experience difficulties or discomfort when exposed to such situations [<xref ref-type="bibr" rid="B2">American Psychological Association (APA), 2020</xref>].</p>
<p>Although resilience was initially seen as a fixed trait, it is currently considered a dynamic process that can be modified throughout life (<xref ref-type="bibr" rid="B8">Chmitorz et al., 2018</xref>; <xref ref-type="bibr" rid="B30">Masten, 2018</xref>). This perspective involves cognitive, attitudinal, and behavioral aspects that can be learned. Therefore, resilience capacity can be enhanced based on strategies that develop these aspects [<xref ref-type="bibr" rid="B2">American Psychological Association (APA), 2020</xref>].</p>
<p>Given that resilience can be strengthened with strategies that favor cognitive, attitudinal, and behavioral aspects, programs focused on resilience have been developed. <xref ref-type="bibr" rid="B25">Laird et al. (2019)</xref> reported that such programs can be implemented preventively to reduce susceptibility to psychopathologies or as treatment for individuals who already have a mental disorder diagnosis, such as depression (<xref ref-type="bibr" rid="B25">Laird et al., 2019</xref>).</p>
<p>Despite many diverse populations may benefit from these interventions, some specific periods of development might be more conducive for implementing strategies that promote resilience. One of these periods is childhood because of the greater brain plasticity and learning capacity during this stage (<xref ref-type="bibr" rid="B31">Masten and Barnes, 2018</xref>). Although it is difficult to define childhood with exact ages, it may be considered up to 11 years of age (<xref ref-type="bibr" rid="B9">DelGiudice, 2018</xref>). Another favorable development phase for the implementation of such interventions is adolescence, which is characterized by the acquisition of executive functions, enabling greater capacity for planning and self-regulation. In addition, this stage of development is characterized by the tendency to associate with peers, which may influence an individual&#x2019;s life trajectory to a more positive path if they associate with peers who exert positive influences (<xref ref-type="bibr" rid="B31">Masten and Barnes, 2018</xref>). Adolescence may be understood as the transition period between childhood and adulthood and considered up to 22 years of age (<xref ref-type="bibr" rid="B13">Goossens, 2006</xref>).</p>
<p>Resilience-focused interventions may involve different approaches, such as the use of pharmacology to treat diseases, physical activities and exercises, and psychological or psychotherapeutic methods. Psychotherapeutic interventions involve, among others, psychoeducational techniques, cognitive-behavioral therapy, problem-solving therapy, and mindfulness. Such psychotherapy-based resilience programs are an interesting intervention possibility as they may show a many beneficial effects, such as increasing momentary well-being, decreasing symptoms of psychopathologies, and promoting individuals&#x2019; ability to recover from adversity (<xref ref-type="bibr" rid="B25">Laird et al., 2019</xref>).</p>
<p>Several resilience-focused programs that were developed may have a wide range of characteristics. They may be aimed toward populations of different ages, be held individually or in groups, be implemented in person or remotely, have varying number and duration of sessions, and have different theoretical approaches (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>; <xref ref-type="bibr" rid="B16">Helmreich et al., 2017</xref>). Given this diversity of characteristics, some review studies and meta-analyses have been conducted to evaluate their effectiveness (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>; <xref ref-type="bibr" rid="B38">Vanhove et al., 2015</xref>; <xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>; <xref ref-type="bibr" rid="B19">Hodder et al., 2017</xref>; <xref ref-type="bibr" rid="B12">Fenwick-Smith et al., 2018</xref>).</p>
<p>These resilience programs have been showing effectiveness in many diverse outcomes. Studies found evidence of such programs in promoting performance and emotional well-being of adult populations in organizational contexts (<xref ref-type="bibr" rid="B38">Vanhove et al., 2015</xref>), reducing stress and depression, and promoting resilience in adults for up to three months after the program completion (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>). In addition, improvements in resilience and protective factors, such as coping skills, internalizing behaviors, and self-efficacy (<xref ref-type="bibr" rid="B12">Fenwick-Smith et al., 2018</xref>) and reduced anxiety symptoms and psychological distress (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>) were found among children after attending universal resilience programs. Among adolescents, such programs seem to reduce internalizing problems (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>) and even reduce the use of illicit substances (<xref ref-type="bibr" rid="B19">Hodder et al., 2017</xref>). Despite these promising results, few studies have analyzed the long-term results of such programs and those that did indicate a tendency of effectiveness decrease as the time passes (<xref ref-type="bibr" rid="B38">Vanhove et al., 2015</xref>; <xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>).</p>
<p>Although the results of such programs seem promising for different outcomes, further studies are needed to analyze their different characteristics and results in other outcomes, such as resilience itself (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>; <xref ref-type="bibr" rid="B16">Helmreich et al., 2017</xref>; <xref ref-type="bibr" rid="B8">Chmitorz et al., 2018</xref>), especially among children and adolescents, given that these developmental stages are considered to be the most favorable phases for implementing strategies that promote resilience (<xref ref-type="bibr" rid="B31">Masten and Barnes, 2018</xref>).</p>
<p>Therefore, the present study aimed to answer the following question: are resilience programs with psychotherapeutic approaches for children and adolescents effective in promoting resilience?</p>
</sec>
<sec id="S2">
<title>Objective</title>
<p>The aim of this study was to assess the effectiveness of resilience-focused programs in promoting resilience in children and adolescents compared to active (treatment as usual, other program modalities, educational curriculum at school) or inactive (waiting list, no treatment) control groups.</p>
</sec>
<sec id="S3">
<title>Method</title>
<p>This systematic review was registered at PROSPERO (CRD42020179874). It followed the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (<xref ref-type="bibr" rid="B33">Page et al., 2021</xref>).</p>
<sec id="S3.SS1">
<title>Eligibility Criteria</title>
<p>The criteria for inclusion in this review were randomized controlled trials (RCTs), studies with a sample of children (&#x003C;12 years old) or adolescents (12 to 22 years old), studies that implemented programs with psychological/psychotherapeutic approaches (psychoeducational, based on mindfulness, cognitive-behavioral therapy, art therapy, among others, and these programs may be implemented individually or in group, face-to-face or online, and involve or not the parents), and studies that assessed resilience as an outcome.</p>
<p>The exclusion criteria were studies that had no control group or without randomization (wrong study design), samples of adults (wrong population), interventions that had no psychological/psychotherapeutic approach (wrong intervention), studies that did not report resilience as an outcome (wrong outcome), protocol records, and abstracts in conferences.</p>
</sec>
<sec id="S3.SS2">
<title>Search Methods</title>
<p>The search strategy was developed with the assistance of the Information Specialist of Brazil Cochrane, according to the Cochrane Handbook for Systematic Reviews of Interventions, Chapter 6. The following electronic databases were searched: Cochrane Central Register of Controlled Trials (CENTRAL, Embase <italic>via</italic> Elsevier, PubMed, and PsycINFO. Key search terms included &#x201C;child&#x201D; OR &#x201C;children&#x201D; OR &#x201C;adolescent&#x201D; OR &#x201C;adolescents&#x201D; AND &#x201C;resilience&#x201D; OR &#x201C;resiliency&#x201D; AND &#x201C;program.&#x201D; The searches were not restricted by date, language, publication status, or publication format. Full detailed search strategy can be found in <xref ref-type="app" rid="A1">Appendix 1</xref>.</p>
</sec>
<sec id="S3.SS3">
<title>Study Selection Process</title>
<p>The selection of studies followed the PRISMA guidelines and was conducted by two independent reviewers (TMP and PGL). First, duplicate records were removed. The titles and abstracts were screened and selected as either potentially eligible or excluded. Those selected as potentially eligible had their full text retrieved. Disagreements in the selection process were discussed with the third author (ECM), and the final inclusion decision of the studies was reached by consensus. The selection of studies was carried out using the <italic>revtools</italic> R package (<xref ref-type="bibr" rid="B40">Westgate, 2019a</xref>,<xref ref-type="bibr" rid="B41">b</xref>) of R software (R 3.6.3 for Windows).</p>
</sec>
<sec id="S3.SS4">
<title>Data Extraction</title>
<p>After selecting the studies, two review authors (TMP and PGL) independently extracted the data in duplicate. Discrepancies were resolved by consensus. We developed data extraction forms to facilitate the standardization of data extraction. The extraction sheet contained the following elements: year of publication, country of study, sample size, age and sex of participants, name of the program, number of sessions and length per session, program implementation setting, theoretical approach, scales used to access the outcome, and time of assessment.</p>
<p>The articles&#x2019; risk of bias was assessed according to the Cochrane Handbook for Systematic Reviews of Interventions (<xref ref-type="bibr" rid="B17">Higgins and Green, 2011</xref>) and judgments were made by consensus. The following domains were assessed: selection bias (random sequence generation and allocation concealment), performance bias (blinding of participants and personnel), detection bias (blinding of outcome assessment), attrition bias (incomplete outcome data), reporting bias (selective reporting), and other biases (cross-contamination). For overall bias, we considered a low overall risk only if all domains were judged as low. We judged studies with some concerns if they were considered to be at an unclear risk for multiple domains but not to be at a high risk for any domain. We judged them as high overall bias if they were considered to be at a high risk in at least one domain. We used the <italic>Robvis</italic> tool to create risk of bias plots (<xref ref-type="bibr" rid="B32">McGuinness and Higgins, 2020</xref>).</p>
<p>For the meta-analysis, we retrieved the following data from each study: number of participants in the experimental and control groups and means (M) and standard deviations (SD) from before and after a program&#x2019;s implementation and from follow-ups of studies that performed this assessment.</p>
</sec>
<sec id="S3.SS5">
<title>Data Analysis</title>
<p>R (<xref ref-type="bibr" rid="B35">R Core Team, 2020</xref>) and the <italic>meta</italic> package (<xref ref-type="bibr" rid="B4">Balduzzi et al., 2019</xref>) were used to perform the meta-analysis. Authors of the papers that did not provide enough data for their inclusion in the meta-analysis were contacted. The procedures for calculations followed the recommendations of <xref ref-type="bibr" rid="B14">Harrer et al. (2019)</xref>. We calculated the standard mean differences (SMD) of the programs&#x2019; effectiveness. We defined a 95% confidence interval (CI) and a statistically significant value of <italic>p</italic> &#x003C; 0.05.</p>
<p>Subgroup analyses were performed separately with samples of children (up to 11 years old) and adolescents (12 to 22 years old). We also analyzed the short-term (&#x2264;3 months), mid-term (3&#x2013;6 months), and long-term (&#x003E; 6 months) follow-up results.</p>
<p>Heterogeneity (<italic>I</italic><sup>2</sup>) among the studies was also assessed. This measure helps provide data on the consistency of results. This percentage was analyzed following the recommendations of <xref ref-type="bibr" rid="B18">Higgins et al. (2003)</xref>: 25% might be considered as low heterogeneity, 50% as moderate heterogeneity, and 75% as high heterogeneity (<xref ref-type="bibr" rid="B18">Higgins et al., 2003</xref>; <xref ref-type="bibr" rid="B14">Harrer et al., 2019</xref>). Therefore, the greater the heterogeneity, the greater the differences between the results of the studies (<xref ref-type="bibr" rid="B18">Higgins et al., 2003</xref>).</p>
<p>The fact that studies reporting higher effect sizes are more likely to be published than those with lower effects may lead to publication bias. Given this, publication bias was assessed according to <xref ref-type="bibr" rid="B20">Hoffman&#x2019;s (2019)</xref> recommendations. This data was presented through a visual analysis in a funnel plot, which considered the SMD vs. the standard error (SE) of studies. Intersections on the <italic>x</italic>-axis closer to zero do not indicate considerable asymmetry, which might be interpreted as a low risk of publication. Statistical significance was assessed using the Egger&#x2019;s test (<xref ref-type="bibr" rid="B20">Hoffman, 2019</xref>).</p>
</sec>
</sec>
<sec sec-type="results" id="S4">
<title>Results</title>
<sec id="S4.SS1">
<title>Search Results</title>
<p>The search resulted in 5,109 records. After duplicates were removed, 4,182 records remained. After screening the titles and abstracts, 302 studies were selected as potentially eligible and had their full text accessed for the final inclusion decision. Of the 302 studies, 285 were excluded for the following reasons: 17 had the wrong study design, 29 had the wrong population, 16 had the wrong intervention, 196 had the wrong outcome, 24 were protocol records, and 3 were abstracts in conferences. Therefore, 17 studies were included in this review. <xref ref-type="fig" rid="F1">Figure 1</xref> shows a flow diagram of the study.</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption><p>Study flow diagram.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g001.tif"/>
</fig>
</sec>
<sec id="S4.SS2">
<title>Study Characteristics</title>
<sec id="S4.SS2.SSS1">
<title>Year of Publication</title>
<p>In this systematic review, we included 17 RCTs. Four studies were published in 2019 (<xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>); two each in 2013 (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>), 2014 (<xref ref-type="bibr" rid="B5">Castro-Olivo, 2014</xref>; <xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>), 2015 (<xref ref-type="bibr" rid="B28">Leventhal et al., 2015</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>), 2018 (<xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B42">Yeun and Woo, 2018</xref>), and 2020 (<xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>). Only one study was published in 2010 (<xref ref-type="bibr" rid="B22">Hyun et al., 2010</xref>), 2016 (<xref ref-type="bibr" rid="B7">Chisholm et al., 2016</xref>), and 2017 (<xref ref-type="bibr" rid="B29">Li et al., 2017</xref>). <xref ref-type="fig" rid="F2">Figure 2</xref> shows the number of studies published each year.</p>
<fig id="F2" position="float">
<label>FIGURE 2</label>
<caption><p>Studies published per year.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g002.tif"/>
</fig>
</sec>
<sec id="S4.SS2.SSS2">
<title>Place of Study</title>
<p>Australia was the country where most studies were carried out (<italic>n</italic> = 5), followed by China (<italic>n</italic> = 3), United States (<italic>n</italic> = 2), South Korea (<italic>n</italic> = 2), and Iran (<italic>n</italic> = 2). One study was conducted in each country: Finland, India, and the United Kingdom.</p>
</sec>
<sec id="S4.SS2.SSS3">
<title>Sample Size and Participants</title>
<p>Sample size ranged from 27 (<xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>) to 2,996 (<xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>). Most studies included only one control group (<italic>n</italic> = 13). It could be an active control group that received a form of attention (<xref ref-type="bibr" rid="B22">Hyun et al., 2010</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>; <xref ref-type="bibr" rid="B7">Chisholm et al., 2016</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B42">Yeun and Woo, 2018</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>) or an inactive control group that received no attention (<xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>; <xref ref-type="bibr" rid="B5">Castro-Olivo, 2014</xref>; <xref ref-type="bibr" rid="B28">Leventhal et al., 2015</xref>; <xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>; <xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>). Only four studies had both active and inactive control groups (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>).</p>
<p>Adolescents were the target population in most studies (<italic>n</italic> = 11), whereas four studies had only children as participants (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>) and two had children and adolescents as participants (<xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>). Both females and males comprised participants sex in most studies (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>; <xref ref-type="bibr" rid="B5">Castro-Olivo, 2014</xref>; <xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>; <xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B42">Yeun and Woo, 2018</xref>; <xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>; <xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>).</p>
</sec>
<sec id="S4.SS2.SSS4">
<title>Programs Characteristics</title>
<p>Each study implemented a different program. The number of sessions ranged from 5 to 23 and each session ranged from 10 to 120 min. Most programs were implemented in a school setting (<italic>n</italic> = 11). All programs were implemented face-to-face, and the cognitive-behavioral theory (CBT) was the most frequently approach reported (<italic>n</italic> = 5).</p>
</sec>
<sec id="S4.SS2.SSS5">
<title>Measurement Tools and Follow-up</title>
<p>Finally, the Connor-Davidson Resilience Scale (CD-RISC) was the most used scale to assess the results (<italic>n</italic> = 6). Nine studies performed at least three assessments: before, after, and at least one follow-up (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>; <xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>) and eight studies had only two assessments: before and after the program (<xref ref-type="bibr" rid="B22">Hyun et al., 2010</xref>; <xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>; <xref ref-type="bibr" rid="B5">Castro-Olivo, 2014</xref>; <xref ref-type="bibr" rid="B28">Leventhal et al., 2015</xref>; <xref ref-type="bibr" rid="B7">Chisholm et al., 2016</xref>; <xref ref-type="bibr" rid="B42">Yeun and Woo, 2018</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>).</p>
<p><xref ref-type="table" rid="T1">Table 1</xref> summarizes the main characteristics of each study.</p>
<table-wrap position="float" id="T1">
<label>TABLE 1</label>
<caption><p>Characteristics of included studies.</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td/>
<td/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
</tr>
<tr>
<td valign="top" align="left"><bold>References</bold></td>
<td valign="top" align="left"><bold>Country</bold></td>
<td valign="top" align="center"><bold><italic>n</italic></bold></td>
<td valign="top" align="left"><bold>Population</bold></td>
<td valign="top" align="left"><bold>Age</bold></td>
<td valign="top" align="left"><bold>Sex</bold></td>
<td valign="top" align="left"><bold>Program</bold></td>
<td valign="top" align="left"><bold>Sessions (length)</bold></td>
<td valign="top" align="left"><bold>Setting</bold></td>
<td valign="top" align="left"><bold>Modality</bold></td>
<td valign="top" align="left"><bold>Format</bold></td>
<td valign="top" align="left"><bold>Approach</bold></td>
<td valign="top" align="left"><bold>Scale</bold></td>
<td valign="top" align="left"><bold>Time of assessment</bold></td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td/>
<td/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
<td valign="top" align="justify"/>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B1">Adibsereshki et al. (2019)</xref></td>
<td valign="top" align="left">Iran</td>
<td valign="top" align="left">122 (61 at EG and 61 at inactive CG)</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">12&#x2013;15 years</td>
<td valign="top" align="left">48 females; 74 males</td>
<td valign="top" align="left">&#x2212;</td>
<td valign="top" align="left">12 (75 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Connor-Davidson Resilience Scale (CD-RISC)</td>
<td valign="top" align="left">3 (pre, post and 2 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B3">Anticich et al. (2013)</xref></td>
<td valign="top" align="left">Australia</td>
<td valign="top" align="left">488 (159 at EG [Fun FRIENDS], 196 at active CG [You Can Do It], and 133 at inactive CG)</td>
<td valign="top" align="left">Children</td>
<td valign="top" align="left">4&#x2013;7 years</td>
<td valign="top" align="left">271 females; 217 males</td>
<td valign="top" align="left">Fun FRIENDS</td>
<td valign="top" align="left">12 (&#x2212;)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">CBT</td>
<td valign="top" align="left">Devereux Early Childhood Assessment Clinical Form (DECA-C)</td>
<td valign="top" align="left">3 (pre, post and 12 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B5">Castro-Olivo (2014)</xref></td>
<td valign="top" align="left">United States</td>
<td valign="top" align="left">102 (49 at EG and 53 at inactive CG)</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">Mean 13.9 years</td>
<td valign="top" align="left">51 females; 51 males</td>
<td valign="top" align="left">Jovenes Fuertes &#x2212; Social-Emotional Learning (SEL)</td>
<td valign="top" align="left">12 (&#x2212;)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Behavior Emotional Rating Scale (BERS-2)</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B6">Chen et al. (2014)</xref></td>
<td valign="top" align="left">China</td>
<td valign="top" align="left">32 (10 at EG, 10 at active CG [GS] and 12 at inactive CG)</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">Mean 14.5 years</td>
<td valign="top" align="left">(&#x2212;) females; (&#x2212;) males</td>
<td valign="top" align="left">Children and Disaster: Teaching Recovery Techniques</td>
<td valign="top" align="left">6 (60 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">CBT</td>
<td valign="top" align="left">Connor-Davidson Resilience Scale (CD-RISC)</td>
<td valign="top" align="left">3 (pre, post and 3 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B7">Chisholm et al. (2016)</xref></td>
<td valign="top" align="left">United Kingdom</td>
<td valign="top" align="left">657 (354 at EG and 303 at active CG [EC])</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">12&#x2013;13 years</td>
<td valign="top" align="left">657 males</td>
<td valign="top" align="left">SchoolSpace</td>
<td valign="top" align="left">11 (10 to 60 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">Psychoeducational</td>
<td valign="top" align="left">Resilience Scale 15-item (RS-15)</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B11">Druker et al. (2019)</xref></td>
<td valign="top" align="left">Australia</td>
<td valign="top" align="left">27 (13 at EG and 14 at active CG [Therapy])</td>
<td valign="top" align="left">Children</td>
<td valign="top" align="left">Mean 4.3 years</td>
<td valign="top" align="left">11 females; 16 males</td>
<td valign="top" align="left">Stuttering therapy + Resilient component</td>
<td valign="top" align="left">12 (70 min)</td>
<td valign="top" align="left">Therapeutic setting</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Curtin Early Childhood Stuttering Resilience Scale (CECSRS)</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B15">Hatamizadeh et al. (2020)</xref></td>
<td valign="top" align="left">Iran</td>
<td valign="top" align="left">122 (61 at EG and 61 at inactive CG)</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">12 &#x2013; 15 years</td>
<td valign="top" align="left">48 females; 74 males</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">12 (&#x2212;)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">Positive psychology</td>
<td valign="top" align="left">Connor-Davidson resilience scale (CD-RISC)</td>
<td valign="top" align="left">3 (pre, post and 2 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B21">Hood et al. (2018)</xref></td>
<td valign="top" align="left">United States</td>
<td valign="top" align="left">264 (133 at EG and 131 at active CG [EC])</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">14&#x2013;18 years</td>
<td valign="top" align="left">158 females; 106 males</td>
<td valign="top" align="left">Penn Resilience Program for type 1 diabetes (PRP T1D)</td>
<td valign="top" align="left">9 (90 to 120 min)</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">CBT</td>
<td valign="top" align="left">Diabetes Strengths and Resilience-Teen</td>
<td valign="top" align="left">5 (pre, post, 4-, 8- and 12-months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B22">Hyun et al. (2010)</xref></td>
<td valign="top" align="left">South Korea</td>
<td valign="top" align="left">28 (15 at EG and 13 at active CG [EC])</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">12&#x2013;13 years</td>
<td valign="top" align="left">28 males</td>
<td valign="top" align="left">&#x2212;</td>
<td valign="top" align="left">10 (50 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">CBT</td>
<td valign="top" align="left">Korean Adolescent Resilience Scale</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B23">Johnstone et al. (2020)</xref></td>
<td valign="top" align="left">Australia</td>
<td valign="top" align="left">232 (123 at EG [ER], 61 at active CG [BA] and 17 at inactive CG)</td>
<td valign="top" align="left">Children</td>
<td valign="top" align="left">8&#x2013;12 years</td>
<td valign="top" align="left">(&#x2212;) females; (&#x2212;) males</td>
<td valign="top" align="left">Emotion Regulation Program (ER)/ Behavior Activation (BA)</td>
<td valign="top" align="left">8 (50 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">Emotional Regulation/Behavioral Activation</td>
<td valign="top" align="left">The child and youth resilience measure &#x2013; short version (CYRM-12)</td>
<td valign="top" align="left">3 (pre, post and 6 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B26">Lee and Stewart (2013)</xref></td>
<td valign="top" align="left">Australia</td>
<td valign="top" align="left">1,277 (828 at EG and 449 at inactive CG)</td>
<td valign="top" align="left">Children</td>
<td valign="top" align="left">8&#x2013;12 years</td>
<td valign="top" align="left">(&#x2212;) females; (&#x2212;) males</td>
<td valign="top" align="left">Health-promoting school</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">Educational Curriculum</td>
<td valign="top" align="left">California Healthy Kids Survey</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B28">Leventhal et al. (2015)</xref></td>
<td valign="top" align="left">India</td>
<td valign="top" align="left">2,387 (1,681 at EG and 706 at inactive CG)</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">12,9 years</td>
<td valign="top" align="left">2,387 females</td>
<td valign="top" align="left">Girls First Resilience Curriculum (RC)</td>
<td valign="top" align="left">23 (60 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">Positive psychology</td>
<td valign="top" align="left">Connor Davidson Resilience Scale-10 (CD-RISC)</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B29">Li et al. (2017)</xref></td>
<td valign="top" align="left">China</td>
<td valign="top" align="left">790 (595 at EG and 195 at inactive CG)</td>
<td valign="top" align="left">Children and adolescents</td>
<td valign="top" align="left">6&#x2013;17 years</td>
<td valign="top" align="left">382 females; 408 males</td>
<td valign="top" align="left">Child-Caregiver-Advocacy Resilience (ChildCARE)</td>
<td valign="top" align="left">15 (120 min)</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Connor-Davidson Resilience Scale (CD-RISC)</td>
<td valign="top" align="left">3 (pre, 6- and 12-months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B37">Tan and Martin (2015)</xref></td>
<td valign="top" align="left">Australia</td>
<td valign="top" align="left">80 (43 at EG and 37 at active CG [TAU])</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">13&#x2013;18 years</td>
<td valign="top" align="left">60 females; 20 males</td>
<td valign="top" align="left">Taming the Adolescent Mind (TAM)</td>
<td valign="top" align="left">5 (60 min)</td>
<td valign="top" align="left">Therapeutic setting</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">Mindfulness</td>
<td valign="top" align="left">Resiliency Scales for Children and Adolescents (RSCA) (<xref ref-type="bibr" rid="B34">Prince-Embury, 2006</xref>)</td>
<td valign="top" align="left">3 (pre, post and 3 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B39">Volanen et al. (2019)</xref></td>
<td valign="top" align="left">Finland</td>
<td valign="top" align="left">2,996 (1,334 at EG [Stop and Breathe/Be], 1,291 at active CG [Relax] and 371 at inactive CG)</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">12&#x2013;15 years</td>
<td valign="top" align="left">(&#x2212;) females; (&#x2212;) males</td>
<td valign="top" align="left">Stop and Breathe/Be</td>
<td valign="top" align="left">9 (45 min)</td>
<td valign="top" align="left">School</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Resilience scale 14-item (RS-14)</td>
<td valign="top" align="left">3 (pre, post and 4 months follow-up)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B42">Yeun and Woo (2018)</xref></td>
<td valign="top" align="left">South Korea</td>
<td valign="top" align="left">62 (30 at EG and 32 at active CG [TAU])</td>
<td valign="top" align="left">Adolescents</td>
<td valign="top" align="left">13&#x2013;17 years</td>
<td valign="top" align="left">48 females; 14 males</td>
<td valign="top" align="left">Interpersonal Relationship improvement program (IRIP)</td>
<td valign="top" align="left">6 (60 min)</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">Ego-resiliency scale</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
<tr>
<td valign="top" align="left"><xref ref-type="bibr" rid="B43">Zhang et al. (2019)</xref></td>
<td valign="top" align="left">China</td>
<td valign="top" align="left">106 (53 at EG and 53 at active CG [TAU])</td>
<td valign="top" align="left">Children and adolescents</td>
<td valign="top" align="left">8&#x2013;18 years</td>
<td valign="top" align="left">54 females; 52 males</td>
<td valign="top" align="left">&#x2013;</td>
<td valign="top" align="left">5 (&#x2212;)</td>
<td valign="top" align="left">Hospital</td>
<td valign="top" align="left">Group</td>
<td valign="top" align="left">Presential</td>
<td valign="top" align="left">CBT</td>
<td valign="top" align="left">Connor-Davidson resilience scale (CD-RISC)</td>
<td valign="top" align="left">2 (pre and post)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p><italic>EG, experimental group; CG, control group; GS, general support; EC, educational curriculum; TAU, treatment as usual; ER, emotional regulation; BA, behavioral activation; -, Not reported; and CBT, cognitive-behavioral therapy.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec id="S4.SS3">
<title>Risk of Bias</title>
<p>We assessed the risk of bias according to the following domains: (D1) random sequence generation, (D2) allocation concealment, (D3) blinding of participants and personnel, (D4) blinding of outcome assessment, (D5) incomplete outcome data, (D6) selective reporting, (D7) cross contamination, and (D8) overall bias.</p>
<p>As all studies were at a high risk for at least one domain, all of them were rated as having a high overall risk of bias (D8). All studies were rated as a low risk for (D1) random sequence generation, as we only included RCTs in the systematic review. As the aims of the studies were to assess the programs&#x2019; efficacy, it was difficult to ensure the blinding of participants and personnel, and the outcome of every study was assessed through self-report measures; therefore, the blinding of outcome could not be ensured as well. Therefore, these domains (D3 and D4) were frequently rated as unclear or a high risk. Similarly, a few studies could ensure that cross contamination (D7) between participants of different groups did not occur. <xref ref-type="fig" rid="F3">Figure 3</xref> shows the risk of bias for each domain for all studies and <xref ref-type="fig" rid="F4">Figure 4</xref>, for each domain for each study.</p>
<fig id="F3" position="float">
<label>FIGURE 3</label>
<caption><p>Risk of bias for all studies.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g003.tif"/>
</fig>
<fig id="F4" position="float">
<label>FIGURE 4</label>
<caption><p>Risk of bias for each study.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g004.tif"/>
</fig>
<p>Publication bias was assessed visually through a funnel plot inspection (<xref ref-type="fig" rid="F5">Figure 5</xref>), which considered the SMD and SE of the studies. The funnel plot did not indicate considerable asymmetry, as the intersection on the <italic>x</italic>-axis was close to zero. Egger test performed for asymmetry confirmed this result (<italic>p</italic> = 0.02). Therefore, the likelihood of publication bias could be considered low.</p>
<fig id="F5" position="float">
<label>FIGURE 5</label>
<caption><p>Publication risk funnel plot.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g005.tif"/>
</fig>
</sec>
<sec id="S4.SS4">
<title>Quantitative Results</title>
<p>Of the 17 studies included in this review, four did not provide the necessary statistical data for their inclusion in the meta-analysis (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B28">Leventhal et al., 2015</xref>; <xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>). We contacted the authors but did not obtain a reply. Consequently, only 13 studies were included in the meta-analysis (<xref ref-type="bibr" rid="B22">Hyun et al., 2010</xref>; <xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>; <xref ref-type="bibr" rid="B5">Castro-Olivo, 2014</xref>; <xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>; <xref ref-type="bibr" rid="B7">Chisholm et al., 2016</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B42">Yeun and Woo, 2018</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>; <xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>).</p>
<p>For studies that had multiple control groups (active and inactive control groups), we opted to conduct the analyses with the inactive control groups to compare if the interventions would be better than no treatment. The study of <xref ref-type="bibr" rid="B23">Johnstone et al. (2020)</xref> included two experimental groups: Emotional Regulation (ER) and Behavioral Activation (BA); but for the meta-analysis, we considered the ER group, as the main objective of their study was to assess the effectiveness of a novel treatment. In addition, <xref ref-type="bibr" rid="B43">Zhang et al. (2019)</xref> analyzed their results in subgroups, a sample of children, and another sample of adolescents; therefore, this study had two different samples for control and experimental groups, and it was considered twice in our analysis.</p>
<p>The random SMD of meta-analysis indicated an overall increase in resilience immediately after the completion of programs, thereby supporting the intervention (SMD = 0.48, 95% CI [0.15, 0.81], <italic>p</italic> = 0.0077). Heterogeneity among studies might be considered high (<italic>I</italic><sup>2</sup> = 88%, 95% CI [81%, 92%], <italic>p</italic> &#x003C; 0.001).</p>
</sec>
<sec id="S4.SS5">
<title>Subgroup Analysis</title>
<p>Subgroup analyses were also performed. The first subgroup comprised adolescents (12&#x2013;22 years old). Ten studies provided data for this analysis (<xref ref-type="bibr" rid="B22">Hyun et al., 2010</xref>; <xref ref-type="bibr" rid="B5">Castro-Olivo, 2014</xref>; <xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>; <xref ref-type="bibr" rid="B7">Chisholm et al., 2016</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B42">Yeun and Woo, 2018</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>; <xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>). Results for this subgroup analysis indicated a significant increase in resilience (SMD = 0.48, 95% CI [0.08, 0.88], <italic>p</italic> = 0.02). Heterogeneity among studies was also high (<italic>I</italic><sup>2</sup> = 89%, 95% CI [81%, 93%], <italic>p</italic> &#x003C; 0.001).</p>
<p>The second subgroup was composed exclusively of children (&#x003C;12 years old). Four studies provided enough data for this analysis (<xref ref-type="bibr" rid="B26">Lee and Stewart, 2013</xref>; <xref ref-type="bibr" rid="B11">Druker et al., 2019</xref>; <xref ref-type="bibr" rid="B43">Zhang et al., 2019</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>). The results of this subgroup indicated no significant increase in resilience (SMD = 0.48, 95% CI [&#x2212;0.64, 1.61], <italic>p</italic> = 0.26). Although only four studies were included, the heterogeneity of the sample could be considered high (<italic>I</italic><sup>2</sup> = 85%, 95% CI [64%, 94%], <italic>p</italic> &#x003C; 0.001).</p>
<p><xref ref-type="fig" rid="F6">Figure 6</xref> graphically represents the overall and subgroup results of the programs&#x2019; effectiveness in promoting resilience immediately after their conclusion.</p>
<fig id="F6" position="float">
<label>FIGURE 6</label>
<caption><p>Overall and subgroup effects of programs on resilience.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g006.tif"/>
</fig>
</sec>
<sec id="S4.SS6">
<title>Follow-up Analysis</title>
<p>Four studies conducted short-term follow-up (&#x2264;3 months) (<xref ref-type="bibr" rid="B6">Chen et al., 2014</xref>; <xref ref-type="bibr" rid="B37">Tan and Martin, 2015</xref>; <xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>; <xref ref-type="bibr" rid="B15">Hatamizadeh et al., 2020</xref>), but two of which did not provide the necessary data to be included in this analysis (<xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B1">Adibsereshki et al., 2019</xref>). Therefore, only three studies were included in the short-term follow-up period. This analysis did not indicate significant results in the short-term (SMD = 0.96, 95% CI [0.14, 1.78], <italic>p</italic> = 0.26). Its heterogeneity was considered moderate (<italic>I</italic><sup>2</sup> = 46%, 95% CI [0%, 84%], <italic>p</italic> = 0.15).</p>
<p>Four studies conducted mid-term follow-up (3 to 6 months) (<xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>; <xref ref-type="bibr" rid="B39">Volanen et al., 2019</xref>; <xref ref-type="bibr" rid="B23">Johnstone et al., 2020</xref>), but one study could not be included because the authors did not provide the results of the follow-up (<xref ref-type="bibr" rid="B29">Li et al., 2017</xref>). <xref ref-type="bibr" rid="B21">Hood et al. (2018)</xref> and <xref ref-type="bibr" rid="B39">Volanen et al. (2019)</xref> performed a follow-up at 4 months, whereas <xref ref-type="bibr" rid="B23">Johnstone et al. (2020)</xref> performed only one follow-up at 6 months. This analysis indicated continuation of results in the mid-term follow-up (SMD = 0.12, 95% CI [&#x2212;0.44, 0.69], <italic>p</italic> = 0.02). Heterogeneity was considered moderate (<italic>I</italic> = 39%, 95% CI [0%, 81%], <italic>p</italic> = 0.19).</p>
<p>Three RCTs conducted long-term follow-up (&#x003E; 6 months; <xref ref-type="bibr" rid="B3">Anticich et al., 2013</xref>; <xref ref-type="bibr" rid="B29">Li et al., 2017</xref>; <xref ref-type="bibr" rid="B21">Hood et al., 2018</xref>). Although <xref ref-type="bibr" rid="B3">Anticich et al. (2013)</xref> and <xref ref-type="bibr" rid="B29">Li et al. (2017)</xref> also performed a 12-month follow-up, they provided insufficient data. <xref ref-type="bibr" rid="B21">Hood et al. (2018)</xref> reported two long-term follow-ups (8 and 12 months); we opted to use the 12-month follow-up, as it was the longest assessment.</p>
<p>The overall follow-up analysis indicated the programs&#x2019; effectiveness in maintaining an enhanced resilience, thereby supporting the intervention [SMD = 0.44, 95% CI [0.00, 0.88], <italic>p</italic> = 0.05). Heterogeneity was considered high (<italic>I</italic><sup>2</sup> = 87%, 95% CI [75%, 93%], <italic>p</italic> &#x003C; 0.001). <xref ref-type="fig" rid="F7">Figure 7</xref> graphically shows the follow-up results.</p>
<fig id="F7" position="float">
<label>FIGURE 7</label>
<caption><p>Follow-up effects of program on resilience.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyg-12-754115-g007.tif"/>
</fig>
</sec>
</sec>
<sec sec-type="discussion" id="S5">
<title>Discussion</title>
<p>This systematic review aimed to address the effectiveness of resilience programs for children and adolescents. To our knowledge, this is the first systematic review with this aim. Our main findings indicate that such programs are effective in promoting overall resilience. The subgroup analysis in the present review did not indicate changes in resilience for children, but did for the adolescents&#x2019; subgroup, indicating significant results in enhancing resilience for this population. These findings may be due to the reduced number of studies in the children&#x2019;s subgroup, which may not have been enough to provide significant changes in resilience levels. Although childhood and adolescence are characterized by brain development and the acquisition of important cognitive functions, the adolescent phase has a greater tendency to associate with peers (<xref ref-type="bibr" rid="B31">Masten and Barnes, 2018</xref>). This tendency of association may favor the expansion of social support networks and work as an extra facilitator that contributes to greater resilience alongside the implementation of resilience-focused programs.</p>
<p>Our follow-up analysis showed that results are maintained for up to six months. In this direction, other studies demonstrate that results of these programs also seem to be maintained for months after the end of programs (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>; <xref ref-type="bibr" rid="B36">Sander et al., 2016</xref>; <xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>). However, differently from these findings, <xref ref-type="bibr" rid="B38">Vanhove et al. (2015)</xref> did not verify the maintenance of resilience-focused programs in enhanced emotional well-being in a follow-up analysis, but unlike the present study, <xref ref-type="bibr" rid="B38">Vanhove et al.&#x2019;s (2015)</xref> review included only studies that implemented programs in working settings and included only the adult population, which may have contributed to such findings.</p>
<p>Resilience has become an increasingly popular topic, and programs focused on its promotion have been developed and studied in the last years. As some reviews show, resilience programs may have a diverse range of characteristics, such as different populations, theoretical approaches, quantity and length of sessions, and settings of implementation (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>; <xref ref-type="bibr" rid="B16">Helmreich et al., 2017</xref>; <xref ref-type="bibr" rid="B25">Laird et al., 2019</xref>). Analyzing these aspects of programs, most RCT included in our systematic review implemented programs with CBT approaches. In the same direction, CBT was one of the most frequently approaches identified by other systematic reviews (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>; <xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>). Our study identified that the programs ranged from 5 to 23 sessions. Similarly, <xref ref-type="bibr" rid="B10">Dray et al. (2017)</xref> report that the programs analyzed by their systematic review ranged from 5 to 32 weeks, <xref ref-type="bibr" rid="B27">Leppin et al. (2014)</xref> report programs ranging from 1 to 24 sessions, and <xref ref-type="bibr" rid="B19">Hodder et al. (2017)</xref> identified programs lasting from 2 days to 10 years. Each session of the programs included in the present review ranged from 10 to 120 min. <xref ref-type="bibr" rid="B10">Dray et al.&#x2019;s (2017)</xref> systematic review indicate similar results, with sessions ranging from 15 to 120 min, whereas <xref ref-type="bibr" rid="B27">Leppin et al. (2014)</xref> report longer sessions ranging from 40 to 150 min. In the present review, adolescents were the target population in majority of the included RCT and face-to-face programs implemented at the school were the most frequent. The school setting was also one of the most frequently reported by other systematic reviews when children and/or adolescents were the target population (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>; <xref ref-type="bibr" rid="B19">Hodder et al., 2017</xref>; <xref ref-type="bibr" rid="B12">Fenwick-Smith et al., 2018</xref>). Additionally, self-report scales were frequently used among the included studies, and CD-RISC was the most reported measurement tool to assess resilience. Although other systematic reviews have analyzed the effects of programs on different outcomes, self-report scales were also the most used measurement tool to assess the effectiveness of such programs (<xref ref-type="bibr" rid="B36">Sander et al., 2016</xref>; <xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>).</p>
<p>Despite this diversity of characteristics, such programs may lead to diverse beneficial outcomes, not only improving resilience itself, but also decreasing stress and depression (<xref ref-type="bibr" rid="B27">Leppin et al., 2014</xref>), anxiety symptoms and psychological distress, internalizing problems (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>), and reducing consumption of illicit substances (<xref ref-type="bibr" rid="B19">Hodder et al., 2017</xref>).</p>
<p>The results of the present study indicated the effectiveness of programs with psychotherapeutic strategies in promoting resilience but although the promising results, these findings should be interpreted with caution. Some limitations of this study must be considered. The first limitation refers to the impossibility of including four studies in the main meta-analysis because of the lack of available data, and most of the included studies were rated as having a high overall risk of bias. This high risk of bias, however, seems to be a common result in systematic reviews of resilience programs; it could even be an expected result, as other systematic reviews that also assessed the risk of bias of mental health and psychological programs had similar conclusions (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>; <xref ref-type="bibr" rid="B19">Hodder et al., 2017</xref>). The second limitation refers to the variation in the sample size of studies, different number of sessions, diverse program approaches, and diversity of scales used to assess the outcomes. This diversity in characteristics across studies might lead to diverse results, which makes drawing definitive conclusions on programs efficacy more difficult. Finally, the heterogeneity of studies might be considered high, even in the subgroup analysis. However, this heterogeneity could also be expected, given the diversity of the studies and the fact that similar reviews found similar results, ranging from moderate (<xref ref-type="bibr" rid="B38">Vanhove et al., 2015</xref>; <xref ref-type="bibr" rid="B19">Hodder et al., 2017</xref>; <xref ref-type="bibr" rid="B24">Joyce et al., 2018</xref>) to high heterogeneity (<xref ref-type="bibr" rid="B10">Dray et al., 2017</xref>; <xref ref-type="bibr" rid="B24">Joyce et al., 2018</xref>).</p>
<p>Still, this systematic review provides an overview of existing resilience-focused programs for children and adolescents and provides relevant data for the field, as our findings may help to guide future actions and interventions aimed to promote resilience. By implementing such interventions as early as possible with the juvenile population, we may promote not only resilience and our ability to cope and recover from the adversities that are so common in today&#x2019;s world, but also promote better public health outcomes as more resilient individuals tend deal better with situations of adversity that can facilitate mental health problems. Therefore, the school may be a key setting for carrying out such programs, as we find many children and adolescents gathered in schools.</p>
</sec>
<sec sec-type="conclusion" id="S6">
<title>Conclusion</title>
<p>We might conclude that the present systematic review contributes to the body of evidence in the field of resilience programs, as it provides an overview of resilience-focused programs for children and adolescents and our results suggest its effectiveness in promoting resilience, especially among adolescents. Additionally, these results are maintained for up to six months as shown in follow-up analysis.</p>
<p>It is noteworthy that future studies that analyze the effectiveness of programs with different characteristics from those included in the present review, such as interventions implemented online or individually, are still necessary to contribute to the growing evidence in this field and to help developing increasingly effective interventions.</p>
</sec>
<sec sec-type="data-availability" id="S7">
<title>Data Availability Statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="S8">
<title>Author Contributions</title>
<p>TP and EM designed the study. TP and PL performed the search and data extraction. PL performed the statistical calculations. TP wrote the first draft of this manuscript. TP, CM, PL, and EM participated in the review and contributed to the writing. All authors contributed to the article and approved the final version of the manuscript.</p>
</sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="S9">
<title>Publisher&#x2019;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</body>
<back>
<sec sec-type="funding-information" id="S10">
<title>Funding</title>
<p>This work was supported by the Funda&#x00E7;&#x00E3;o de Amparo &#x00E0; Pesquisa do Estado de S&#x00E3;o Paulo (FAPESP; grant numbers: 2019/08921-4 and 2018/09654-7) and Conselho Nacional de Desenvolvimento Cient&#x00ED;fico e Tecnol&#x00F3;gico (CNPq; grant number: 309159/2019-9).</p>
</sec>
<app-group>
<app id="A1">
<title>Appendix</title>
<sec id="A1.SS1">
<title>Appendix 1. Search strategy</title>
<p>(((resilien<sup>&#x2217;</sup> NEAR/5 (train<sup>&#x2217;</sup> OR program<sup>&#x2217;</sup> OR intervention<sup>&#x2217;</sup> OR promot<sup>&#x2217;</sup> OR prevent<sup>&#x2217;</sup> OR enhanc<sup>&#x2217;</sup> OR learn<sup>&#x2217;</sup> OR teach<sup>&#x2217;</sup> OR educat<sup>&#x2217;</sup> OR increas<sup>&#x2217;</sup> OR develop<sup>&#x2217;</sup> OR manag<sup>&#x2217;</sup> OR therap<sup>&#x2217;</sup> OR protocol<sup>&#x2217;</sup> OR treat<sup>&#x2217;</sup>)) OR (hardiness<sup>&#x2217;</sup> NEAR/5 (train<sup>&#x2217;</sup> OR program<sup>&#x2217;</sup> OR intervention<sup>&#x2217;</sup> OR promot<sup>&#x2217;</sup> OR prevent<sup>&#x2217;</sup> OR enhanc<sup>&#x2217;</sup> OR learn<sup>&#x2217;</sup> OR teach<sup>&#x2217;</sup> OR educat<sup>&#x2217;</sup> OR increas<sup>&#x2217;</sup> OR develop<sup>&#x2217;</sup> OR manag<sup>&#x2217;</sup> OR therap<sup>&#x2217;</sup> OR protocol<sup>&#x2217;</sup> OR treat<sup>&#x2217;</sup>)) OR ((&#x2018;psychological resilience&#x2019;/exp OR &#x2018;social adaptation&#x2019;/exp OR &#x2018;coping behavior&#x2019;/exp OR &#x2018;post-traumatic growth&#x2019; OR &#x2018;posttraumatic growth&#x2019; OR &#x2018;stress-related growth&#x2019; OR (positiv<sup>&#x2217;</sup> NEAR/1 (adapt<sup>&#x2217;</sup> OR adjust<sup>&#x2217;</sup>)) OR resilien<sup>&#x2217;</sup> OR hardiness<sup>&#x2217;</sup> OR cope OR coping OR ((overcom<sup>&#x2217;</sup> OR resis<sup>&#x2217;</sup> OR recover<sup>&#x2217;</sup> OR thri<sup>&#x2217;</sup> OR adapt<sup>&#x2217;</sup> OR adjust<sup>&#x2217;</sup>) NEAR/5 (stress<sup>&#x2217;</sup> OR trauma<sup>&#x2217;</sup> OR adversit<sup>&#x2217;</sup>)) OR &#x2018;psychologic adaptation&#x2019; OR &#x2018;psychological adaptation&#x2019;) AND (&#x2018;psychotherapy&#x2019;/exp OR &#x2018;psychological stress&#x2019; OR &#x2018;psychological stresses&#x2019; OR psychotherap<sup>&#x2217;</sup> OR psycho-therap<sup>&#x2217;</sup> OR (behav<sup>&#x2217;</sup> NEAR/3 (intervention<sup>&#x2217;</sup> OR program<sup>&#x2217;</sup> OR therap<sup>&#x2217;</sup>)) OR ((cbt OR &#x2018;cognitive behavioral&#x2019; OR &#x2018;cognitive behavior&#x2019; OR cognition) NEAR/3 (intervention<sup>&#x2217;</sup> OR program<sup>&#x2217;</sup> OR therap<sup>&#x2217;</sup>)) OR (psycho<sup>&#x2217;</sup> NEAR/3 (intervention<sup>&#x2217;</sup> OR program<sup>&#x2217;</sup> OR therap<sup>&#x2217;</sup>)) OR counseling OR coaching OR mindful<sup>&#x2217;</sup> OR relaxation OR (&#x2018;third wave&#x2019; NEAR/1 (psycho<sup>&#x2217;</sup> OR therap<sup>&#x2217;</sup>)) OR &#x2018;cognitive restructuring&#x2019; OR &#x2018;positive psychology&#x2019; OR refram<sup>&#x2217;</sup> OR re-fram<sup>&#x2217;</sup> OR reapprais<sup>&#x2217;</sup> OR (stress NEAR/1 (inoculation OR manag<sup>&#x2217;</sup> OR reduc<sup>&#x2217;</sup> OR resist<sup>&#x2217;</sup>)) OR (anxiety NEAR/3 manage<sup>&#x2217;</sup>) OR &#x2018;acceptance and commitment&#x2019; OR &#x2018;health promotion&#x2019;/exp OR (health NEAR/3 (educat<sup>&#x2217;</sup> OR promot<sup>&#x2217;</sup>))))) AND (&#x2018;randomized controlled trial&#x2019;/exp OR &#x2018;single blind procedure&#x2019;/exp OR &#x2018;double blind procedure&#x2019;/exp OR &#x2018;crossover procedure&#x2019;/exp OR random<sup>&#x2217;</sup>:ab,ti OR placebo<sup>&#x2217;</sup>:ab,ti OR allocat<sup>&#x2217;</sup>:ab,ti OR crossover<sup>&#x2217;</sup>:ab,ti OR &#x2018;cross over&#x2019;:ab,ti OR trial:ti OR ((doubl<sup>&#x2217;</sup> NEXT/1 blind<sup>&#x2217;</sup>):ab,ti)) NOT ((&#x2018;animal&#x2019;/de OR &#x2018;animal experiment&#x2019;/de OR &#x2018;nonhuman&#x2019;/de) NOT ((&#x2018;animal&#x2019;/de OR &#x2018;animal experiment&#x2019;/de OR &#x2018;nonhuman&#x2019;/de) AND &#x2018;human&#x2019;/de)) AND (1990:py OR 1991:py OR 1992:py OR 1993:py OR 1994:py OR 1995:py OR 1996:py OR 1997:py OR 1998:py OR 1999:py OR 2000:py OR 2001:py OR 2002:py OR 2003:py OR 2004:py OR 2005:py OR 2006:py OR 2007:py OR 2008:py OR 2009:py OR 2010:py OR 2011:py OR 2012:py OR 2013:py OR 2014:py OR 2015:py OR 2016:py OR 2017:py OR 2018:py OR 2019:py OR 2020:py OR 2021:py) AND ([adolescent]/lim OR [child]/lim OR [preschool]/lim OR [school]/lim OR [young adult]/lim)) AND (2020:py OR 2021:py)</p>
</sec>
</app>
</app-group>
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