<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3-mathml3.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="case-report" dtd-version="1.3" xml:lang="EN">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title-group>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2025.1738977</article-id>
<article-version article-version-type="Version of Record" vocab="NISO-RP-8-2008"/>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Case Report: Behavioral analysis guided intervention targeting triggers and urges in skin-picking disorder with comorbid onychophagia</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Kawahito</surname><given-names>Makoto</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/3266980/overview"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; original draft" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing &#x2013; original draft</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="methodology" vocab-term-identifier="https://credit.niso.org/contributor-roles/methodology/">Methodology</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="investigation" vocab-term-identifier="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name><surname>Murayama</surname><given-names>Keitaro</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1213598/overview"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &amp; editing</role>
</contrib>
<contrib contrib-type="author">
<name><surname>Tomiyama</surname><given-names>Hirofumi</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="validation" vocab-term-identifier="https://credit.niso.org/contributor-roles/validation/">Validation</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &amp; editing</role>
</contrib>
<contrib contrib-type="author">
<name><surname>Kato</surname><given-names>Kenta</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="visualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/visualization/">Visualization</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &amp; editing</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Data curation" vocab-term-identifier="https://credit.niso.org/contributor-roles/data-curation/">Data curation</role>
</contrib>
<contrib contrib-type="author">
<name><surname>Nakao</surname><given-names>Tomohiro</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/438534/overview"/>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Project-administration" vocab-term-identifier="https://credit.niso.org/contributor-roles/project-administration/">Project administration</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="supervision" vocab-term-identifier="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing &#x2013; review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing &#x2013; review &amp; editing</role>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label><institution>Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University</institution>, <city>Fukuoka</city>,&#xa0;<country country="jp">Japan</country></aff>
<aff id="aff2"><label>2</label><institution>Department of Neuropsychiatry, Kyushu University Hospital</institution>, <city>Fukuoka</city>,&#xa0;<country country="jp">Japan</country></aff>
<author-notes>
<corresp id="c001"><label>*</label>Correspondence: Keitaro Murayama, <email xlink:href="mailto:murayama.keitaro.003@m.kyushu-u.ac.jp">murayama.keitaro.003@m.kyushu-u.ac.jp</email></corresp>
</author-notes>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2026-01-13">
<day>13</day>
<month>01</month>
<year>2026</year>
</pub-date>
<pub-date publication-format="electronic" date-type="collection">
<year>2025</year>
</pub-date>
<volume>16</volume>
<elocation-id>1738977</elocation-id>
<history>
<date date-type="received">
<day>04</day>
<month>11</month>
<year>2025</year>
</date>
<date date-type="accepted">
<day>16</day>
<month>12</month>
<year>2025</year>
</date>
<date date-type="rev-recd">
<day>15</day>
<month>12</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2026 Kawahito, Murayama, Tomiyama, Kato and Nakao.</copyright-statement>
<copyright-year>2026</copyright-year>
<copyright-holder>Kawahito, Murayama, Tomiyama, Kato and Nakao</copyright-holder>
<license>
<ali:license_ref start_date="2026-01-13">https://creativecommons.org/licenses/by/4.0/</ali:license_ref>
<license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>Skin-picking disorder (SPD) often co-occurs with onychophagia and can cause substantial functional impairment. Although evidence-based psychotherapies are effective, benefits may be limited when behavioral analysis is not applied explicitly.</p>
</sec>
<sec>
<title>Case presentation</title>
<p>A 29-year-old man with SPD and onychophagia reported marked occupational impact. Baseline self-monitoring showed 240 min/day of nail-related behavior, 30 episodes/day, and high urge intensity. Using behavioral chain analysis, we mapped perceptual antecedents (visual/tactile irregularities) and diurnal variability of urges. A medication-free, nine-session outpatient program over 20 weeks was delivered, combining stimulus control, urge management routines, and habit reversal training. Outcomes were tracked by daily self-monitoring. Rapid improvement followed initiation of stimulus control and consolidated after urge management routines. By treatment end, daily picking time decreased to 15 min/day (-94%), episode frequency to 5/day (-83%), and urge intensity to 4/10 (-60%); no adverse effects were reported.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Making perceptual antecedents and diurnal moderators explicit based on chain analysis enabled a targeted, medication-free intervention that produced clinically meaningful reductions in behavior and urges. A chain-guided behavioral framework may help personalize treatment for SPD and related body-focused repetitive behaviors.</p>
</sec>
</abstract>
<kwd-group>
<kwd>behavioral analysis</kwd>
<kwd>case report</kwd>
<kwd>habit reversal training</kwd>
<kwd>onychophagia</kwd>
<kwd>skin-picking disorder</kwd>
<kwd>stimulus control</kwd>
</kwd-group>
<funding-group>
<funding-statement>The author(s) declared that financial support was not received for this work and/or its publication.</funding-statement>
</funding-group>
<counts>
<fig-count count="3"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="16"/>
<page-count count="7"/>
<word-count count="2475"/>
</counts>
<custom-meta-group>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Anxiety and Stress Disorders</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro">
<label>1</label>
<title>Introduction</title>
<p>Skin-picking disorder (SPD), also known as excoriation disorder, is characterized by recurrent skin picking that results in significant distress and functional impairment across social, occupational, and financial domains (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>). Within the obsessive-compulsive and related disorders (OCRD) spectrum, SPD frequently co-occurs with onychophagia (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B3">3</xref>). Estimates of SPD prevalence range from 1.4% to 5.4%, with onset typically occurring during adolescence (<xref ref-type="bibr" rid="B4">4</xref>). Although patients with SPD have a lower quality of life than healthy controls, less than one-fifth seek treatment (<xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B3">3</xref>). Psychotherapy is an evidence-based intervention for treating SPD. Psychotherapeutic approaches include cognitive-behavioral therapy (CBT), habit reversal training (HRT), and acceptance and commitment therapy (ACT) (<xref ref-type="bibr" rid="B5">5</xref>). CBT generally involves psychoeducation, cognitive restructuring, and an emphasis on relapse prevention (<xref ref-type="bibr" rid="B4">4</xref>, <xref ref-type="bibr" rid="B6">6</xref>). HRT includes awareness and competing response training (<xref ref-type="bibr" rid="B7">7</xref>). ACT promotes the acceptance of negative thoughts and feelings, and focuses on personal values and goals (<xref ref-type="bibr" rid="B8">8</xref>). Although these approaches are effective, their benefits may be constrained when sensory antecedents and internal states are not explicitly assessed or targeted (<xref ref-type="bibr" rid="B9">9</xref>).</p>
<p>We report a medication-free, brief outpatient intervention for SPD that systematically maps perceptual antecedents (visual/tactile irregularities) and diurnal variability in urges using behavioral chain analysis and then applies focused stimulus control and urge management procedures. This case illustrates rapid clinical improvement over nine sessions and highlights how making antecedents explicit can enhance behavioral interventions for SPD and related body-focused repetitive behaviors (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B11">11</xref>). Key outcomes were tracked with structured self-monitoring, and the methodological details and measures are described below.</p>
</sec>
<sec id="s2">
<label>2</label>
<title>Case description</title>
<sec id="s2_1">
<label>2.1</label>
<title>Patient information</title>
<p>A 29-year-old right-handed man presented with chronic skin-picking and nail-biting since childhood, which caused substantial occupational impairment. The patient worked long hours in a high-demand professional setting and reported spending prolonged periods each day engaging in nail-related behaviors at work. The patient attempted to conceal the behavior but was unable to stop it. There was no history of neurodevelopmental, psychiatric, mood, or substance use disorders, or other relevant medical illnesses. The patient had no family history of OCRDs.</p>
</sec>
<sec id="s2_2">
<label>2.2</label>
<title>Clinical findings</title>
<p>This behavior involved only the fingernails and adjacent periungual skin. The nails were shortened so that the free edges of the nail plates were no longer visible, with marked peeling of the lateral nail folds (<xref ref-type="fig" rid="f1"><bold>Figure&#xa0;1</bold></xref>). No distinct dermatological conditions requiring specific treatment were identified. The patient expressed shame and distress regarding loss of control and work delays. At baseline, self-monitoring indicated approximately 240 min/day of nail-related behavior, with a frequency of approximately 30 episodes per day. The self-rated urge intensity (0&#x2013;10 scale) was 10 at baseline. These measures were the median values between visits. Episodes typically begin with the tactile and visual detection of uneven skin/nails, followed by an escalating urge, picking/biting, and transient relief.</p>
<fig id="f1" position="float">
<label>Figure&#xa0;1</label>
<caption>
<p>Baseline and post-treatment nail appearance. Left: At baseline (Session 1), free edges of nail plates are not visible; marked peeling of lateral nail folds. Right: After Session 9, free edges are visible with reduced periungual peeling.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1738977-g001.tif">
<alt-text content-type="machine-generated">Two images of hands placed on flat surfaces. The left image shows a hand with dry, peeling of the surrounding skin and slight redness, while the right image shows a similar hand with healthier nails and reduced redness.</alt-text>
</graphic></fig>
</sec>
</sec>
<sec id="s3">
<label>3</label>
<title>Diagnostic assessment</title>
<p>The patient met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for SPD, which is characterized by recurrent skin picking with unsuccessful attempts to decrease or stop, clinically significant distress, and functional impairment (<xref ref-type="bibr" rid="B1">1</xref>). Onychophagia, which is not classified as a separate disorder in the DSM-5, also presents as nail-focused repetitive behavior (<xref ref-type="bibr" rid="B12">12</xref>). At the diagnostic assessment, no other mental disorders, including OCRDs, anxiety disorders, or depressive disorders, were identified in the clinical interviews.</p>
<p>We used daily self-monitoring with three indices (duration, episode frequency, and urge intensity) to quantify the behavioral output and subjective urges. Symptom severity and impact in SPD are commonly assessed with the Skin Picking Scale (SPS) and the Skin Picking Impact Scale (SPIS) (<xref ref-type="bibr" rid="B13">13</xref>&#x2013;<xref ref-type="bibr" rid="B15">15</xref>). SPS comprises six items assessing: (i) frequency of urge to pick, (ii) intensity of urge to pick, (iii) time spent picking, (iv) interference due to skin picking, (v) distress due to picking/distress when prevented from picking, and (vi) avoidance behavior due to picking (<xref ref-type="bibr" rid="B13">13</xref>). The SPIS includes ten items capturing psychosocial consequences, dissatisfaction with appearance, and negative self-evaluation (<xref ref-type="bibr" rid="B14">14</xref>, <xref ref-type="bibr" rid="B15">15</xref>). However, because validated Japanese versions of the standardized SPD scales were not available in our setting at the time of assessment, we selected these three SPS-aligned indices as our primary outcomes. This pragmatic approach allowed us to track changes in behavioral output and subjective urges.</p>
<p>At the outset, the diagnosis and evidence-based treatment options were explained, and the treatment goals were aligned. The patient subsequently engaged in nine outpatient behavioral sessions for 20 weeks (approximately 30 min each, scheduled every 2&#x2013;4 weeks).</p>
</sec>
<sec id="s4">
<label>4</label>
<title>Therapeutic intervention and outcomes</title>
<p>The first author (M.K.), a psychiatrist, conducted nine brief outpatient behavioral sessions that were conducted over 20 weeks without pharmacotherapy (<xref ref-type="table" rid="T1"><bold>Table&#xa0;1</bold></xref>). The intervention sequence was individualized based on functional chain analysis and iteratively refined based on patient self-monitoring of min/day, episodes/day, and urge intensity (0&#x2013;10).</p>
<table-wrap id="T1" position="float">
<label>Table&#xa0;1</label>
<caption>
<p>Timeline of the nine-session intervention and outcomes across 20 weeks.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="middle" align="center">Sessions</th>
<th valign="middle" align="center">Key components</th>
<th valign="middle" align="center">Details</th>
<th valign="middle" align="center">Picking time (min/day)</th>
<th valign="middle" align="center">Episode frequency (episodes/day)</th>
<th valign="middle" align="center">Urge intensity (0-10)</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">Psychoeducation &amp; self-monitoring</td>
<td valign="middle" align="center">Explain disorder, align goals. Initiate self-monitoring after each episode.</td>
<td valign="middle" align="center">240</td>
<td valign="middle" align="center">30</td>
<td valign="middle" align="center">10</td>
</tr>
<tr>
<td valign="middle" align="center">2</td>
<td valign="middle" align="center">Behavioral analysis &amp; HRT</td>
<td valign="middle" align="center">Antecedents not yet identified. Introduce competing responses (gum/gummy candy; hand-sized ball).</td>
<td valign="middle" align="center">210</td>
<td valign="middle" align="center">28</td>
<td valign="middle" align="center">9</td>
</tr>
<tr>
<td valign="middle" align="center">3</td>
<td valign="middle" align="center">Behavioral analysis &amp; Stimulus control (initiated)</td>
<td valign="middle" align="center">Logs clarified that episodes began with tactile and visual detection of uneven skin/nail, followed by escalating urge, then picking/biting and transient relief. Begin smoothing/covering (hand cream; adhesive bandages).</td>
<td valign="middle" align="center">200</td>
<td valign="middle" align="center">26</td>
<td valign="middle" align="center">9</td>
</tr>
<tr>
<td valign="middle" align="center">4</td>
<td valign="middle" align="center">Stimulus control (continued)</td>
<td valign="middle" align="center">Marked reduction in daily duration and frequency.</td>
<td valign="middle" align="center">90</td>
<td valign="middle" align="center">13</td>
<td valign="middle" align="center">7</td>
</tr>
<tr>
<td valign="middle" align="center">5</td>
<td valign="middle" align="center">Urge-management (initiated)</td>
<td valign="middle" align="center">Addressed diurnal variability: added a 15-min noon nap; scheduled late-day music/talk radio. Continued stimulus-control at work.</td>
<td valign="middle" align="center">60</td>
<td valign="middle" align="center">10</td>
<td valign="middle" align="center">6</td>
</tr>
<tr>
<td valign="middle" align="center">6</td>
<td valign="middle" align="center">Urge-management (continued) &amp; chain refinement</td>
<td valign="middle" align="center">Gains consolidated.</td>
<td valign="middle" align="center">30</td>
<td valign="middle" align="center">10</td>
<td valign="middle" align="center">6</td>
</tr>
<tr>
<td valign="middle" align="center">7</td>
<td valign="middle" align="center">Lifestyle management</td>
<td valign="middle" align="center">Temporary increase with peak workload/irregular sleep; implemented a fixed sleep schedule guided by the mapped chain.</td>
<td valign="middle" align="center">60</td>
<td valign="middle" align="center">12</td>
<td valign="middle" align="center">6</td>
</tr>
<tr>
<td valign="middle" align="center">8</td>
<td valign="middle" align="center">Relapse prevention</td>
<td valign="middle" align="center">Reviewed self-monitoring logs and the one-page chain diagram; reinforced relapse-prevention routines.</td>
<td valign="middle" align="center">30</td>
<td valign="middle" align="center">10</td>
<td valign="middle" align="center">5</td>
</tr>
<tr>
<td valign="middle" align="center">9</td>
<td valign="middle" align="center">Maintenance</td>
<td valign="middle" align="center">Review logs/chain diagram; relapse-prevention plan.</td>
<td valign="middle" align="center">15</td>
<td valign="middle" align="center">5</td>
<td valign="middle" align="center">4</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>Nine brief outpatient behavioral sessions were conducted over 20 weeks (approximately 30 min each, every 2&#x2013;4 weeks). Values are medians of daily self-monitoring recorded between consecutive visits: picking time (min/day), episode frequency (episodes/day), and urge intensity (0-10). Baseline = Session 1. HRT, habit reversal training.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>Session 1&#x2013;2. M.K. provided psychoeducation that frames skin-picking and nail-biting as treatable behaviors, normalizes help-seeking, and aligns functional goals (improved control and reduced time loss at work). While the patient initially attributed his symptoms to stress or personality deficits, he reported significant relief upon re-conceptualizing the behavior as a treatable disorder serving a sensory regulatory function. In Session 1, a structured daily self-monitoring log was introduced. The patient was instructed to record entries immediately following each picking/biting episode. The log components included: (i) time of day, (ii) duration of the behavior, (iii) urge intensity (rated 0&#x2013;10), and (iv) situational context/triggers. Habit reversal elements, including competing responses (chewing gum or gummy candy, and squeezing a hand-sized ball), were introduced. However, the antecedents had not yet been identified. Psychoeducation reduced distress, self-monitoring clarified behavioral patterns, and competing responses delayed initiation; however, the overall daily duration and frequency showed little change during this phase (<xref ref-type="table" rid="T1"><bold>Table&#xa0;1</bold></xref>).</p>
<p>Session 3&#x2013;4. Repeated logs revealed a consistent behavioral chain: tactile/visual detection of periungual irregularities led to an escalating urge, followed by picking/biting and transient relief (<xref ref-type="fig" rid="f2"><bold>Figure&#xa0;2</bold></xref>). Based on this formulation, stimulus control targeting perceptual antecedents was implemented, consisting of smoothing/covering strategies (regular use of hand cream and adhesive bandages, as needed) to reduce the salience of uneven nail/skin surfaces. A rapid response ensued: daily picking time declined to 90 min/day by Session 4, and episode frequency was nearly halved (<xref ref-type="fig" rid="f3"><bold>Figure&#xa0;3</bold></xref>).</p>
<fig id="f2" position="float">
<label>Figure&#xa0;2</label>
<caption>
<p>Behavioral analysis and targeted interventions. Self-monitoring reveals a chain beginning with perceptual antecedents (visual/tactile irregularities), followed by urge escalation (amplified by fatigue and short sleep), resulting in picking/biting of nails and periungual skin, transient sensory relief, and shame/distress post-episode. Interventions are mapped at each step: awareness/self-monitoring, stimulus control (hand cream, adhesive bandages), urge management (15-minute noon nap; music/radio late in the day), and HRT (habit reversal training) competing responses (chewing gum/gummy candy; squeezing a hand-sized ball).</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1738977-g002.tif">
<alt-text content-type="machine-generated">Flowchart depicting a behavioral chain of nail and skin picking. It starts with &#x201c;Antecedents: Visual/tactile detection of uneven nail/skin&#x201d; leading to &#x201c;Urge escalation: Fatigue and short sleep amplify urges,&#x201d; followed by &#x201c;Behavior: Picking/biting nails and periungual skin,&#x201d; and &#x201c;Consequences: Sensory reward and transient relief.&#x201d; Arrows connect these stages in a repeated cycle, emphasizing difficulty in stopping once initiated. Interventions include &#x201c;Awareness,&#x201d; &#x201c;Stimulus control,&#x201d; &#x201c;Urge management,&#x201d; and &#x201c;Habit reversal training&#x201d; like using hand cream, taking naps, and chewing gum.</alt-text>
</graphic></fig>
<fig id="f3" position="float">
<label>Figure&#xa0;3</label>
<caption>
<p>Daily self-monitoring outcomes across the 20-week intervention. <bold>(A)</bold> Daily picking time (min/day), <bold>(B)</bold> episode frequency (episodes/day), and <bold>(C)</bold> urge intensity (0&#x2013;10). Points represent medians of daily entries between consecutive visits; week 0 = baseline (Session 1), week 20 = post-treatment (Session 9).</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1738977-g003.tif">
<alt-text content-type="machine-generated">Three line charts illustrate data trends over 20 weeks. Chart A shows a decrease in daily picking time from 240 to 15 minutes. Chart B depicts episode frequency dropping from 30 to 5 episodes per day. Chart C shows urge intensity declining from 10 to 4 on a zero to ten scale. Each chart indicates significant reductions over time.</alt-text>
</graphic></fig>
<p>Session 5&#x2013;6. Because urges showed diurnal variability and worsened with evening fatigue and short sleep, a brief 15-minute planned nap at noon was added, and listening to music/talk radio during late-day work periods was scheduled. Combined with ongoing stimulus control, these procedures consolidated gains with a daily picking time of approximately 30&#x2013;60 min/day and reduced episode counts (<xref ref-type="fig" rid="f3"><bold>Figure&#xa0;3</bold></xref>). During this phase, a behavioral chain diagram (<xref ref-type="fig" rid="f2"><bold>Figure&#xa0;2</bold></xref>) was developed and refined.</p>
<p>Session 7. A temporary increase in symptoms coincided with peak workload and irregular sleep, which amplified evening urges. A fixed sleep schedule was instituted, guided by a previously mapped behavioral chain.</p>
<p>Session 8&#x2013;9. The patient reviewed self-monitoring notes and a one-page behavioral chain diagram. The patient reported improved insights into his behavioral chain and treatment rationale. By the end of the treatment, the daily picking time had decreased from 240 to 15 min/day (-94%), episode frequency from 30 to 5 episodes/day (-83%), and urge intensity from 10 to 4 (-60%). These improvements were maintained throughout the treatment period. No adverse events were observed.</p>
</sec>
<sec id="s5">
<label>5</label>
<title>Patient perspective</title>
<p>&#x201c;For years, I believed that stopping this habit was simply a matter of willpower, and I felt ashamed every time I failed. Identifying my specific triggers was a turning point. Seeing my behavior chain mapped out helped me understand the &#x2018;why&#x2019; and &#x2018;how&#x2019; of my picking aimed at sensory regulation, rather than just blaming my personality. Simple prevention steps improved my appearance and daily life. Having a clear logic made it easier to manage urges before they escalated.&#x201d;</p>
</sec>
<sec id="s6" sec-type="discussion">
<label>6</label>
<title>Discussion</title>
<p>This single-case report illustrates a mechanism-informed behavioral formulation and intervention for skin-picking disorder with comorbid onychophagia. By mapping perceptual antecedents (visual/tactile irregularities) and temporal moderators (fatigue and short sleep) through chain analysis, we selected targeted stimulus control and urge management procedures. A rapid improvement followed the antecedent-focused strategies, and gains were consolidated when sleep and late-day attention shift routines were introduced, without pharmacotherapy.</p>
<p>Automatic and focused patterns of skin-picking are often discussed. The automatic pattern (less conscious and weakly articulated antecedents) tended to respond to the HRT and upstream antecedent interventions. In contrast, the focused pattern is enacted intentionally to modulate internal states (e.g., anxiety, tension, and disgust) and is theoretically aligned with ACT-consistent procedures (<xref ref-type="bibr" rid="B16">16</xref>). In clinical practice, many patients exhibit both features. Thus, an early priority is to analyze the behavior, identify the functional chain, and select the most appropriate intervention for each process (<xref ref-type="fig" rid="f2"><bold>Figure&#xa0;2</bold></xref>). Previous studies suggested that combined protocols could yield additional improvements (<xref ref-type="bibr" rid="B16">16</xref>). In this case, self-monitoring helped make the behavioral chain explicit, stimulus control targeted antecedents, urge management strategies addressed urges, and HRT provided competing responses to replace maladaptive behaviors.</p>
<p>A clinically meaningful asynchrony emerged: the time spent and the frequency of picking/biting decreased substantially, whereas urge intensity decreased to a lesser extent. Conceptually, stimulus control and HRT are well-suited to disrupt cue-response chains and reduce overt behavioral output, but they may not directly modify the subjective urge experience, which is shaped by private events and state-dependent factors. Considering this pattern, adding ACT components might yield further reductions in the urge intensity.</p>
<p>The strengths of this case include: (i) a mechanism-informed, chain-guided formulation that directly determines intervention selection and sequencing, offering a transparent and replicable rationale; (ii) daily monitoring with three complementary indices&#x2014;duration, episode frequency, and self-rated urge intensity&#x2014;which detected the clinically relevant asynchrony between reductions in behavioral output and the change in subjective urges; and iii) clinically meaningful gains achieved without medication, using affordable, scalable methods suitable for standard care.</p>
<p>The limitations include those inherent to a single case report without condition control: potential threats to internal validity (history, maturation, measurement reactivity, and expectancy), reliance on self-reports without independent blinded ratings, and a short follow-up, leaving durability and relapse risk uncertain. Because multiple components were introduced sequentially, we could not isolate the active ingredients or determine the optimal order; therefore, an alternative sequence might have produced different results. Generalizability is constrained by the behavior&#x2019;s localization to the nails and periungual skin and the single-provider setting. Finally, quality of life and functional impairment were not measured using standardized instruments, limiting inferences about broader functioning.</p>
</sec>
<sec id="s7" sec-type="conclusions">
<label>7</label>
<title>Conclusion</title>
<p>In patients with SPD and onychophagia, a behavioral chain analysis that explicitly mapped perceptual antecedents and diurnal variability guided a targeted, medication-free intervention. Combining stimulus control with urge management produced a rapid reduction in daily picking time, episode frequency, and urge intensity, which was maintained throughout the treatment period. These findings highlight the value of mechanism-informed, chain-guided behavioral analyses for SPD.</p>
</sec>
</body>
<back>
<sec id="s8" sec-type="data-availability">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p></sec>
<sec id="s9" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.</p></sec>
<sec id="s10" sec-type="author-contributions">
<title>Author contributions</title>
<p>MK: Conceptualization, Writing &#x2013; original draft, Methodology, Investigation. KM: Supervision, Writing &#x2013; review &amp; editing. HT: Validation, Writing &#x2013; review &amp; editing. KK: Visualization, Writing &#x2013; review &amp; editing, Data curation. TN: Project administration, Supervision, Writing &#x2013; review &amp; editing.</p></sec>
<ack>
<title>Acknowledgments</title>
<p>We would like to thank Editage (<ext-link ext-link-type="uri" xlink:href="http://www.editage.jp">www.editage.jp</ext-link>) for English language editing.</p>
</ack>
<sec id="s12" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec>
<sec id="s13" sec-type="ai-statement">
<title>Generative AI statement</title>
<p>The author(s) declared that generative AI was used in the creation of this manuscript. The first author used ChatGPT (GPT-5 Thinking, OpenAI; used on 30 October 2025) to make minor language edits to this manuscript under human oversight and full author responsibility. The output was reviewed and revised by the author. No AI tool was used for study design, data analysis, data interpretation, or image generation.</p>
<p>Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.</p></sec>
<sec id="s14" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p></sec>
<ref-list>
<title>References</title>
<ref id="B1">
<label>1</label>
<mixed-citation publication-type="book">
<person-group person-group-type="author"><collab>American Psychiatric Association</collab>
</person-group>. <source>Diagnostic and Statistical Manual of Mental Disorders</source>. <edition>5th ed</edition>. <publisher-loc>Arlington, VA</publisher-loc>: 
<publisher-name>American Psychiatric Publishing</publisher-name> (<year>2013</year>).
</mixed-citation>
</ref>
<ref id="B2">
<label>2</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Flessner</surname> <given-names>CA</given-names></name>
<name><surname>Woods</surname> <given-names>DW</given-names></name>
</person-group>. 
<article-title>Phenomenological characteristics, social problems, and the economic impact associated with chronic skin picking</article-title>. <source>Behav Modif</source>. (<year>2006</year>) <volume>30</volume>:<page-range>944&#x2013;63</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1177/0145445506294083</pub-id>, PMID: <pub-id pub-id-type="pmid">17050772</pub-id>
</mixed-citation>
</ref>
<ref id="B3">
<label>3</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Odlaug</surname> <given-names>BL</given-names></name>
<name><surname>Grant</surname> <given-names>JE</given-names></name>
</person-group>. 
<article-title>Clinical characteristics and medical complications of pathologic skin picking</article-title>. <source>Gen Hosp Psychiatry</source>. (<year>2008</year>) <volume>30</volume>:<page-range>61&#x2013;6</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/j.genhosppsych.2007.07.009</pub-id>, PMID: <pub-id pub-id-type="pmid">18164942</pub-id>
</mixed-citation>
</ref>
<ref id="B4">
<label>4</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Lochner</surname> <given-names>C</given-names></name>
<name><surname>Roos</surname> <given-names>A</given-names></name>
<name><surname>Stein</surname> <given-names>DJ</given-names></name>
</person-group>. 
<article-title>Excoriation (skin-picking) disorder: a systematic review of treatment options</article-title>. <source>Neuropsychiatr Dis Treat</source>. (<year>2017</year>) <volume>13</volume>:<page-range>1867&#x2013;72</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.2147/NDT.S121138</pub-id>, PMID: <pub-id pub-id-type="pmid">28761349</pub-id>
</mixed-citation>
</ref>
<ref id="B5">
<label>5</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Selles</surname> <given-names>RR</given-names></name>
<name><surname>McGuire</surname> <given-names>JF</given-names></name>
<name><surname>Small</surname> <given-names>BJ</given-names></name>
<name><surname>Storch</surname> <given-names>EA</given-names></name>
</person-group>. 
<article-title>A systematic review and meta-analysis of psychiatric treatments for excoriation (skin-picking) disorder</article-title>. <source>Gen Hosp Psychiatry</source>. (<year>2016</year>) <volume>41</volume>:<fpage>29</fpage>&#x2013;<lpage>37</lpage>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/j.genhosppsych.2016.04.001</pub-id>, PMID: <pub-id pub-id-type="pmid">27143352</pub-id>
</mixed-citation>
</ref>
<ref id="B6">
<label>6</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Schuck</surname> <given-names>K</given-names></name>
<name><surname>Keijsers</surname> <given-names>GP</given-names></name>
<name><surname>Rinck</surname> <given-names>M</given-names></name>
</person-group>. 
<article-title>The effects of brief cognitive-behaviour therapy for pathological skin picking: a randomized comparison to wait-list control</article-title>. <source>Behav Res Ther</source>. (<year>2011</year>) <volume>49</volume>:<page-range>11&#x2013;7</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/j.brat.2010.09.005</pub-id>, PMID: <pub-id pub-id-type="pmid">20934685</pub-id>
</mixed-citation>
</ref>
<ref id="B7">
<label>7</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Azrin</surname> <given-names>NH</given-names></name>
<name><surname>Nunn</surname> <given-names>RG</given-names></name>
</person-group>. 
<article-title>Habit-reversal: a method of eliminating nervous habits and tics</article-title>. <source>Behav Res Ther</source>. (<year>1973</year>) <volume>11</volume>:<page-range>619&#x2013;28</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/0005-7967(73)90119-8</pub-id>, PMID: <pub-id pub-id-type="pmid">4777653</pub-id>
</mixed-citation>
</ref>
<ref id="B8">
<label>8</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Twohig</surname> <given-names>MP</given-names></name>
<name><surname>Hayes</surname> <given-names>SC</given-names></name>
<name><surname>Masuda</surname> <given-names>A</given-names></name>
</person-group>. 
<article-title>A preliminary investigation of acceptance and commitment therapy as a treatment for chronic skin picking</article-title>. <source>Behav Res Ther</source>. (<year>2006</year>) <volume>44</volume>:<page-range>1513&#x2013;22</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/j.brat.2005.10.002</pub-id>, PMID: <pub-id pub-id-type="pmid">16368072</pub-id>
</mixed-citation>
</ref>
<ref id="B9">
<label>9</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Teng</surname> <given-names>EJ</given-names></name>
<name><surname>Woods</surname> <given-names>DW</given-names></name>
<name><surname>Twohig</surname> <given-names>MP</given-names></name>
</person-group>. 
<article-title>Habit reversal as a treatment for chronic skin picking: a pilot investigation</article-title>. <source>Behav Modif</source>. (<year>2006</year>) <volume>30</volume>:<page-range>411&#x2013;22</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1177/0145445504265707</pub-id>, PMID: <pub-id pub-id-type="pmid">16723422</pub-id>
</mixed-citation>
</ref>
<ref id="B10">
<label>10</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Snorrason</surname> <given-names>I</given-names></name>
<name><surname>Woods</surname> <given-names>DW</given-names></name>
</person-group>. 
<article-title>Nail picking disorder (onychotillomania): a case report</article-title>. <source>J Anxiety Disord</source>. (<year>2014</year>) <volume>28</volume>:<page-range>211&#x2013;4</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/j.janxdis.2013.10.004</pub-id>, PMID: <pub-id pub-id-type="pmid">24291396</pub-id>
</mixed-citation>
</ref>
<ref id="B11">
<label>11</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Cohen</surname> <given-names>PR</given-names></name>
</person-group>. 
<article-title>Nail-associated body-focused repetitive behaviors: habit-tic nail deformity, onychophagia, and onychotillomania</article-title>. <source>Cureus</source>. (<year>2022</year>) <volume>14</volume>:<fpage>e22818</fpage>. doi:&#xa0;<pub-id pub-id-type="doi">10.7759/cureus.22818</pub-id>, PMID: <pub-id pub-id-type="pmid">35382180</pub-id>
</mixed-citation>
</ref>
<ref id="B12">
<label>12</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Lee</surname> <given-names>DK</given-names></name>
<name><surname>Lipner</surname> <given-names>SR</given-names></name>
</person-group>. 
<article-title>Update on diagnosis and management of onychophagia and onychotillomania</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2022</year>) <volume>19</volume>:<elocation-id>3392</elocation-id>. doi:&#xa0;<pub-id pub-id-type="doi">10.3390/ijerph19063392</pub-id>, PMID: <pub-id pub-id-type="pmid">35329078</pub-id>
</mixed-citation>
</ref>
<ref id="B13">
<label>13</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Flessner</surname> <given-names>CA</given-names></name>
<name><surname>Busch</surname> <given-names>AM</given-names></name>
<name><surname>Heideman</surname> <given-names>PW</given-names></name>
<name><surname>Woods</surname> <given-names>DW</given-names></name>
</person-group>. 
<article-title>Acceptance-enhanced behavior therapy (AEBT) for trichotillomania and chronic skin picking: exploring the effects of component sequencing</article-title>. <source>Behav Modif</source>. (<year>2008</year>) <volume>32</volume>:<page-range>579&#x2013;94</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1177/0145445507313800</pub-id>, PMID: <pub-id pub-id-type="pmid">18334614</pub-id>
</mixed-citation>
</ref>
<ref id="B14">
<label>14</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Keuthen</surname> <given-names>NJ</given-names></name>
<name><surname>Wilhelm</surname> <given-names>S</given-names></name>
<name><surname>Deckersbach</surname> <given-names>T</given-names></name>
<name><surname>Engelhard</surname> <given-names>IM</given-names></name>
<name><surname>Forker</surname> <given-names>AE</given-names></name>
<name><surname>Baer</surname> <given-names>L</given-names></name>
<etal/>
</person-group>. 
<article-title>The Skin Picking Scale: scale construction and psychometric analyses</article-title>. <source>J Psychosom Res</source>. (<year>2001</year>) <volume>50</volume>:<page-range>337&#x2013;41</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1016/S0022-3999(01)00215-X</pub-id>, PMID: <pub-id pub-id-type="pmid">11438115</pub-id>
</mixed-citation>
</ref>
<ref id="B15">
<label>15</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Keuthen</surname> <given-names>NJ</given-names></name>
<name><surname>Deckersbach</surname> <given-names>T</given-names></name>
<name><surname>Wilhelm</surname> <given-names>S</given-names></name>
<name><surname>Engelhard</surname> <given-names>IM</given-names></name>
<name><surname>Forker</surname> <given-names>AE</given-names></name>
<name><surname>O&#x2019;Sullivan</surname> <given-names>RL</given-names></name>
<etal/>
</person-group>. 
<article-title>The Skin Picking Impact Scale (SPIS): scale development and psychometric analyses</article-title>. <source>Psychosomatics</source>. (<year>2001</year>) <volume>42</volume>:<fpage>397</fpage>&#x2013;<lpage>403</lpage>. doi:&#xa0;<pub-id pub-id-type="doi">10.1176/appi.psy.42.5.397</pub-id>, PMID: <pub-id pub-id-type="pmid">11739906</pub-id>
</mixed-citation>
</ref>
<ref id="B16">
<label>16</label>
<mixed-citation publication-type="journal">
<person-group person-group-type="author">
<name><surname>Snorrason</surname> <given-names>I</given-names></name>
<name><surname>Olafsson</surname> <given-names>RP</given-names></name>
<name><surname>Flessner</surname> <given-names>CA</given-names></name>
<name><surname>Keuthen</surname> <given-names>NJ</given-names></name>
<name><surname>Franklin</surname> <given-names>ME</given-names></name>
<name><surname>Woods</surname> <given-names>DW</given-names></name>
</person-group>. 
<article-title>The Skin Picking Impact Scale: factor structure, validity and development of a short version</article-title>. <source>Scand J Psychol</source>. (<year>2013</year>) <volume>54</volume>:<page-range>344&#x2013;8</page-range>. doi:&#xa0;<pub-id pub-id-type="doi">10.1111/sjop.12057</pub-id>, PMID: <pub-id pub-id-type="pmid">23682651</pub-id>
</mixed-citation>
</ref>
</ref-list>
<fn-group>
<fn id="n1" fn-type="custom" custom-type="edited-by">
<p>Edited by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/776153">Fabrizio Stasolla</ext-link>, Giustino Fortunato University, Italy</p></fn>
<fn id="n2" fn-type="custom" custom-type="reviewed-by">
<p>Reviewed by: <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/2819817">Hasan Demirci</ext-link>, University of Health Sciences, T&#xfc;rkiye</p>
<p><ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/3281944">Hiroaki Harai</ext-link>, Harai Consulting &amp; Training, Japan</p></fn>
</fn-group>
</back>
</article>