AUTHOR=Verity Lily , Burke Lauren , Qualter Pamela TITLE=Loneliness in adolescence: prevalence, developmental contexts, and interventions JOURNAL=Frontiers in Psychiatry VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1696981 DOI=10.3389/fpsyt.2025.1696981 ISSN=1664-0640 ABSTRACT=Loneliness, though often mistaken for social isolation, is a distinct experience that affects individuals across the lifespan and is especially salient during adolescence. This developmental stage involves profound changes in identity, cognition, and social relationships, which can heighten vulnerability to loneliness. Drawing on global research, this paper highlights the widespread prevalence of adolescent loneliness, with variation shaped by cultural and societal factors. We explore how developmental transitions, shifting relational dynamics, and broader social environments contribute to experiences of disconnection, and consider the implications for mental and physical health. Loneliness in adolescence is associated with a range of negative outcomes, including depression, anxiety, social anhedonia, and increased health risks. Importantly, persistent loneliness may become maladaptive, reinforcing withdrawal through negative expectations and creating self-sustaining cycles of social disconnection. The review further examines intervention strategies aimed at reducing loneliness, including those that enhance social and emotional skills, strengthen supportive relationships, and address maladaptive cognitions. We argue that interventions must differentiate between transient and chronic loneliness, reflect the diversity of adolescent experiences, and prioritize co-production with young people to ensure developmental relevance and cultural sensitivity. Recognizing adolescence as a sensitive period for loneliness underscores the need for timely, evidence-based responses that equip young people to navigate disconnection and foster more supportive social environments.