The consumption of stimulants of both legal and illegal drugs has become a global public health problem among young people (1). The causes are multifactorial, including social context, drug availability, and personal characteristics. The World Health Organization (WHO) highlights that 2.6 million deaths per year were attributable to alcohol consumption (2 million men) and 0.6 million deaths to psychoactive drug use (0.4 million men) (2).

The 2023 Global Burden of Disease (GBD) study (3), suggests that the burden from substance use increases substantially during adolescence and early adulthood. While illicit drugs cause a greater burden in the U.S., Canada, Australia, New Zealand, and Western Europe. Stress is a notable risk factor, as addictions result from biological, environmental, and drug-induced interactions (4). In 2017, approximately 271 million people (5.5% of the global population aged 15–64) used drugs, marijuana was the most consumed illicit drug (188 million users) (5).

Caffeinated beverages, enhance mental alertness, attention, and energy. In Latin America, El Salvador had the highest stimulant use (0.7%), followed by Ecuador (0.6%), with higher rates among men—except in Panama, where women exceeded men. Cannabis consumption in 2019 reached 3.3% in El Salvador and Panama, with the lowest rates in Venezuela, Bolivia, and Peru (around 3.1%) (6).

The consumption of energy drinks alongside other substances has also grown. According to the 2020 EDADES survey (Spain), 12.3% of the population aged 15–64 consumed energy drinks in the past 30 days—15.3% of men and 9.1% of women. Consumption was highest among individuals aged 15–24, with a 32.2% prevalence (38.3% for men and 25.7% for women) (7).

Temple JL (2019), conducted a review of the National Library of Medicine database on the safety of caffeine consumption in children and adolescents, finding that typical, moderate consumption is relatively safe in these groups. Consuming high doses of caffeine (>400 mg) can cause physiological, psychological and behavioral harm, children with psychiatric or cardiac conditions are at greater risk (8). In Honduras, Buchanan and Pillon (2008) reported that university students mainly consumed caffeine, mate, energy drinks, and Coca-Cola, and to a lesser extent, marijuana, cocaine, Valium, and sleep aids. Women consumed these substances to combat fatigue and improve academic performance; men, to have fun and relieve stress (9).

Licona Rivera et al. (2016), in a cross-sectional descriptive study in Honduras where 278 students participated, found that 80 students (29%) used drugs: alcohol (48.8%), energy drinks (16.3%), and marijuana (10%). Among medical students, 34% of them reported consumption, followed by 24% of dental and 22% of nursing students (10). In a sample of 1,510 (77%) Honduran students reported using stimulants during the academic year, with a female majority (55%). The age group under 25 accounted for 95% of the reported use (11).

Previous research has identified several predictive factors for stimulant use among university students, including male gender, higher levels of fatigue, specific academic disciplines with heavier workloads, and elevated stress or anxiety levels. These factors influence consumption patterns through mechanisms such as the perceived need for improved concentration, enhanced alertness, and coping with academic pressure. Understanding these predictors is essential for developing targeted health interventions and for interpreting the variation in consumption across different student populations.

Despite the growing literature on substance use among university students worldwide, there is a lack of recent, comprehensive data from Honduras that examines both caffeinated beverage consumption and other psychoactive substances across different academic disciplines. Previous local studies have either focused on small samples or limited types of substances, hindering the ability to develop tailored prevention strategies. Our study addresses this gap by providing updated epidemiological data from a large, stratified sample of university students, while also identifying sociodemographic and psychosocial predictors of consumption. The objective of this research is to assess the prevalence and predictors of caffeinated beverage and other psychoactive substance use among Honduran university students, with the aim of informing targeted interventions and institutional policies that promote healthier lifestyles and reduce substance-related risks.

A total of 1,181 participants were obtained reach, with 989 (83.7%) declaring coffee consuming 553 (46.8%) energy drinks, and 395 (33.4%) tea. Regarding alcohol consumption, 208 (17.6%) participants consumed alcohol, 107 (9.1%) used tobacco, and 28 (2.4%) used other drugs. Regarding faculties and consumption, the Faculty of Humanities and Arts reported the highest coffee consumption at 85 (89.5%), followed by energy drinks and tea, with the Faculty of Dentistry reporting 4 (80%) and 3 (60%) respectively. Alcohol consumption was 27 (25.7%) and drug consumption 6 (5.7%) was concentrated in the Faculty of Law, while tobacco consumption was highest in the Faculty of Space Sciences with 3 (25%). The results are presented in Table 1 .

The binary logistic regression model identified sex, fatigue (Chalder scale), and faculty of study as significant predictors of energy drink consumption in the last six months: men were 3.2 times more likely to consume energy drinks compared to women (OR = 3.21, 95% CI: 1.91–5.39, p < 0.001). Higher levels of fatigue were associated with a greater likelihood of consuming energy drinks (OR = 2.10, 95% CI: 1.24–3.55, p = 0.006). Students enrolled in Economics were 2.15 times more likely to consume energy drinks compared to those in Medical Sciences (OR = 2.15, 95% CI: 1.06–4.33, p = 0.033). Other factors, such as marital status, age, stress, anxiety, and other groups of professors, showed no statistically significant associations (p > 0.05). The results are presented in Table 2 .

An independent binary logistic regression model evaluated the predictors of lifetime drug use and revealed the following: Men were 2.6 times more likely to use drugs over their lifetime compared to women (OR = 2.62; 95% CI: 1.91–3.59; p < 0.001). Stress was significantly associated with lifetime drug use (OR = 1.58; 95% CI: 1.13–2.22; p = 0.008). Engineering students were significantly less likely to report lifetime drug use compared to medical sciences students (OR = 0.47; 95%CI: 0.22–0.97; p = 0.040). Other predictors, such as marital status, anxiety, insomnia, fatigue (Chalder scale), and energy drink consumption, showed no statistically significant associations with lifetime drug use (p > 0.05). The results are presented in Table 3 .

A Poisson regression model was used to evaluate the predictors of caffeinated beverages consumption rates during the last six months: Men had a 57% higher consumption rate of caffeinated beverages than women (RR = 1.57; 95% CI: 1.47–1.68; p < 0.001). Fatigue (Chalder scale) was associated with a 17% higher caffeinated beverages consumption rate (RR = 1.17; 95% CI: 1.09–1.25; p < 0.001). Anxiety was also a significant predictor (RR = 1.18; 95% CI: 1.08–1.28; p < 0.001).

Students from Economics (RR = 1.13; 95% CI: 1.01–1.26; p = 0.029) and Humanities and Arts (RR = 1.17; 95% CI: 1.02–1.35; p = 0.027) had significantly higher rates of caffeinated beverages consumption compared to students from Engineering. Greater severity of insomnia (ISI scale) was associated with a 19% lower caffeinated beverages consumption rate (RR = 0.81; 95% CI: 0.75–0.87; p < 0.001). Other predictors, including stress (p = 0.052), marital status, and other groups of professors, were not statistically significant. The results are presented in Table 4 .

The objective of the study was to identify the key predictors of consumption of caffeinated beverages (coffee, tea, and energy drinks) and drug use among Honduran university students. Some isolated studies have analyzed university populations by faculty, particularly in Medical and Dental Sciences. According to the International Classification of Diseases, stimulants are substances that alter the functions of the central nervous system. Common examples include cocaine, amphetamines, methamphetamines, and MDMA (3,4-methylenedioxy-methamphetamine) (17). Energy drinks are also considered stimulants due to their high caffeine content, which acts on the CNS to improve physical and cognitive performance. They also typically include taurine, B vitamins, and sugars (18).

A systematic review identified coffee as the most used stimulant among medical students, followed by tea and other forms of caffeine, including energy drinks. These substances are popular because of the belief that they can improve cognitive function quickly and with little effort. Caffeine is consumed by 80% of the global population for its psychoactive effects, and almost 89% in the United States (19).

The study found that coffee was the most consumed caffeinated beverage, followed by energy drinks and tea findings consistent with previous studies like that of Chávez-Gutiérrez J. In our sample, 876 students (58%) consumed coffee, 453 (30%) consumed energy drinks. Notably, 378 students (25%) were unaware of the potential adverse effects, while 1,132 (75%) reported being aware of the risks but continued consumption (11).

Among Honduran university students, 208 (17.6%) consumed alcohol, 107 (9.1%) tobacco, and 28 (2.4%) used other illicit drugs. A cross-sectional study with 325 students from the Faculty of Chemistry and Pharmacy at the National Autonomous University of Honduras revealed that 99 students (30.5%) reported alcohol use, and 29 (8.9%) reported marijuana use (20).

Differences by academic discipline showed that Economics students had significantly higher odds of caffeinated beverages use (OR = 2.15), while Engineering students showed lower odds of lifetime drug use (OR = 0.47). However, further detailed analysis is required to understand how academic workload and environmental factors influence substance use. A study conducted among university students in Tabasco, Mexico, reported increased energy drink consumption during exam periods, indicating specific stress-related risk factors in this population (21).

The consumption of high doses of caffeine has been associated with several health disorders, including sleep disturbances, anxiety, and caffeine toxicity (22–24). In this study, significant predictors of Differences by academic discipline showed that Economics students had significantly higher odds of caffeinated beverages use included male gender, fatigue measured by the Chalder scale, and being enrolled in the Faculty of Economics. A related study at Universidad Latina de Costa Rica showed no significant influence of sex, marital status, employment, or faculty on stimulant use—except for a noted association between nicotine use and sex (25).

Fatigue and anxiety emerged as strong predictors of caffeinated beverages consumption. Higher fatigue levels measured via the Chalder scale, combined with anxiety symptoms, were associated with increased use. Stress also showed a significant correlation with drug use (OR = 1.58; p = 0.008). Risk behaviors such as combining energy drinks with alcohol, tobacco, or illicit drugs were linked to poorer health outcomes, diminished quality of life, and mental health problems. A cohort analysis from the U.S. Nurses’ Health Study 3, involving over 46,000 participants, found high comorbidity between energy drink consumption and use of marijuana, tobacco, alcohol, and other drugs (26).

Fatigue is recognized as a predictor of general and mental health in different populations, affecting quality of life, sleep quality, and emotional well-being (27). Stress and fatigue significantly impact students’ academic success and social adaptability (28). Fatigue emerged as another key predictor in the study, suggesting that students may rely on caffeine as a compensatory strategy to manage academic workload and irregular sleep patterns.

Luneke A. et al. found in a U.S. university study that energy level enhancement and anxiety-related effects were major predictors of energy drink us (29). Similarly, a systematic review and meta-analysis by Nadeem IM et al. showed the top reasons for consuming energy drinks were boosting energy/reducing fatigue (24.5%), staying awake (15.7%), and improving study concentration (14.1%) (30).

In the study, it was found that men consume more drugs over their lifetime compared to women, male students are strongly associated with higher consumption of caffeinated beverages, which may be explained by greater engagement in social behaviors involving such drinks, as well as lower perceived health risks compared to female students. Stress was significantly associated with lifetime drug consumption. Engineering students had a significantly lower probability of reporting lifetime drug use compared to medical sciences students.

Our findings also revealed that men reported higher lifetime drug use compared to women, and stress was strongly associated with that use. Engineering students were significantly less likely to report lifetime drug use compared to students from enrolled in Medical Sciences, could reflect differences in curriculum structure, assessment schedules, and stress management resources available within faculties. These findings suggest that academic environment and field of study play important roles in consumption patterns. Stress linked to academic pressure, lifestyle changes, clinical practice, and the lack of supportive or preventive mechanisms from the educational system can negatively affect students’ mental health and overall education quality (31, 32).

Other demographic and psychosocial variables such as marital status, anxiety, insomnia, and fatigue (as measured by the Chalder scale) did not show statistically significant associations with lifetime drug use in this study. One notable finding was the greater risk of substance consumption among men compared to women (OR = 3.21; OR = 2.62), particularly among males from lower socioeconomic backgrounds (33).

This was consistent with international studies. For instance, research in Italy showed higher prevalence among male university students, often associated with risk behaviors like smoking and alcohol use. These results align with data from the 2018 NaSSDA (National Secondary Students Diet and Activity) survey, which reported that 16% of students consumed at least one energy drink per week (34–36).

Students enrolled in Economics and Humanities and Arts reported significantly higher rates of caffeinated beverages consumption compared to Engineering students. Higher insomnia levels, measured using the ISI scale, were also associated with increased caffeinated beverages use. A particularly concerning trend is the combined use of caffeinated beverages and drugs at social events, such as parties. The cardiovascular effects of caffeine such as elevated heart rate and blood pressure can be exacerbated when combined with alcohol and may impair the perception of intoxication. This interaction increases the risk of overconsumption and acute complications (37).

Our findings align with previous reports indicating higher caffeine consumption among male university students and an association between fatigue and energy drink intake (25, 34, 35), we observed a significant effect of academic discipline, with Economics students showing higher consumption rates than those in Medical Sciences. These differences may reflect variation in academic workload, cultural norms, or access to caffeinated products across faculties. Future research should investigate causal mechanisms and the role of psychosocial stressors in shaping consumption patterns.

The findings of this study contribute to the theoretical understanding of substance use behaviors in university settings by highlighting the interplay between individual factors (e.g., gender, fatigue, stress) and contextual elements (e.g., faculty environment) in shaping consumption patterns. From a practical standpoint, these results support the development of targeted health promotion programs that address both behavioral risk factors and institutional conditions that may encourage caffeine and other psychoactive substance use. Interventions could integrate sleep hygiene education, time management skills, and faculty specific stress reduction initiatives. In terms of policy, universities and health authorities could use these data to inform regulations on the availability and marketing of caffeinated products within campuses, as well as to strengthen mental health services aimed at reducing stress related substance use.

"This study highlights the significant relationship between the male sex, fatigue, and academic discipline as factors associated with caffeinated beverages (coffee, energy drinks) use among Honduran university students, emphasizing the need for specific interventions for this group, especially in faculties such as Economics, where a higher prevalence of consumption is observed. Fatigue, as measured by the Chalder Scale, suggests that students experiencing high levels of fatigue are more likely to turn to stimulants to improve academic performance and combat exhaustion.

It is necessary to re-evaluate the availability and accessibility of caffeinated beverages (coffee, energy drinks) in educational institutions. The implementation of educational programs about the risks of excessive consumption of these substances, along with mental health interventions focused on preventing fatigue and stress management, could mitigate the observed negative effects. Further longitudinal studies are warranted to assess causal relationships and evaluate the effectiveness of preventive measures.