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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2025.1607470</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>The interplay of prenatal stress and prenatal depression in Chinese couples: based on the actor-partner interdependence model</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Liu</surname>
<given-names>Xiaoqing</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn003">
<sup>&#x2020;</sup>
</xref>
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</contrib>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Dong</surname>
<given-names>Yuting</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn003">
<sup>&#x2020;</sup>
</xref>
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<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Zhou</surname>
<given-names>Jungu</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn003">
<sup>&#x2020;</sup>
</xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Lin</surname>
<given-names>Shiying</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Liu</surname>
<given-names>Minghuan</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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</contrib>
<contrib contrib-type="author">
<name>
<surname>Zeng</surname>
<given-names>Hang</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Zhou</surname>
<given-names>Xiaowan</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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<contrib contrib-type="author">
<name>
<surname>Song</surname>
<given-names>Yang</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
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</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Xie</surname>
<given-names>Xiaoxu</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
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</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Liao</surname>
<given-names>Qiuping</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
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<contrib contrib-type="author" corresp="yes">
<name>
<surname>Lin</surname>
<given-names>Shaowei</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
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</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Wu</surname>
<given-names>Siying</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
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<aff id="aff1">
<sup>1</sup>
<institution>Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University</institution>, <addr-line>Fuzhou, Fujian</addr-line>,&#xa0;<country>China</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Fujian Maternity and Child Health Hospital</institution>, <addr-line>Fuzhou, Fujian</addr-line>,&#xa0;<country>China</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>Edited by: Monica Mazzelli, San Giovanni di Dio Fatebenefratelli Center (IRCCS), Italy</p>
</fn>
<fn fn-type="edited-by">
<p>Reviewed by: Yunhong Liu, Shandong University, China</p>
<p>Reem Nashef-Hamuda, Tel Aviv University, Israel</p>
<p>Abdul Salam, Universitas Hasanuddin, Indonesia</p>
</fn>
<fn fn-type="corresp" id="fn001">
<p>*Correspondence: Xiaoxu Xie, <email xlink:href="mailto:xiexiaoxu@aliyun.com">xiexiaoxu@aliyun.com</email>; Qiuping Liao, <email xlink:href="mailto:liaoqiuping@fjmu.edu.cn">liaoqiuping@fjmu.edu.cn</email>; Shaowei Lin, <email xlink:href="mailto:linsw@fjmu.edu.cn">linsw@fjmu.edu.cn</email>; Siying Wu, <email xlink:href="mailto:fmuwsy@163.com">fmuwsy@163.com</email>
</p>
</fn>
<fn fn-type="equal" id="fn003">
<p>&#x2020;These authors have contributed equally to this work and share first authorship</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>31</day>
<month>07</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="ecorrected">
<day>20</day>
<month>08</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2025</year>
</pub-date>
<volume>16</volume>
<elocation-id>1607470</elocation-id>
<history>
<date date-type="received">
<day>09</day>
<month>04</month>
<year>2025</year>
</date>
<date date-type="accepted">
<day>07</day>
<month>07</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2025 Liu, Dong, Zhou, Lin, Liu, Zeng, Zhou, Song, Xie, Liao, Lin and Wu.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Liu, Dong, Zhou, Lin, Liu, Zeng, Zhou, Song, Xie, Liao, Lin and Wu</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Objective</title>
<p>Pregnant women exhibit heightened stress susceptibility and elevated depression risk during gestation, factors associated with adverse outcomes including postpartum depression. Current research predominantly examines maternal experiences while neglecting spousal influences.</p>
</sec>
<sec>
<title>Methods</title>
<p>The study surveyed 282 Chinese married couples using validated scales to assess prenatal stress and depression. And analysed dyadic data from expectant parents using the Actor-Partner Interdependence Model (APIM) to determine the pattern of action of prenatal stress on prenatal depression between couples by calculating the magnitude of the ratio <italic>k</italic> between the partner effect and the actor effect.</p>
</sec>
<sec>
<title>Results</title>
<p>The analysis revealed <italic>k<sub>1</sub>
</italic> = 0.064, 95% <italic>CI:</italic> (-0.113, 0.260) and <italic>k<sub>2</sub>
</italic> = 0.064, 95% <italic>CI</italic>: (-0.118, 0.249). The confidence intervals for both <italic>k<sub>1</sub>
</italic> and <italic>k<sub>2</sub>
</italic> included zero, indicating an actor-only pattern in the APIM. Specifically, prenatal stress positively predicted one&#x2019;s own prenatal depression but did not significantly influence the partner&#x2019;s depression.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>It is crucial to encourage couples to actively manage their stress levels during the prenatal period. This can help to reduce the negative psychological effects of prenatal stress, which may lead to improved pregnancy outcomes and postnatal health.</p>
</sec>
</abstract>
<kwd-group>
<kwd>actor-partner interdependence model (APIM)</kwd>
<kwd>patterns</kwd>
<kwd>prenatal stress</kwd>
<kwd>prenatal depression</kwd>
<kwd>couples&#x2019; mental health</kwd>
</kwd-group>
<contract-sponsor id="cn001">Fujian Medical University<named-content content-type="fundref-id">10.13039/501100013795</named-content>
</contract-sponsor>
<counts>
<fig-count count="4"/>
<table-count count="4"/>
<equation-count count="0"/>
<ref-count count="46"/>
<page-count count="9"/>
<word-count count="3631"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-in-acceptance</meta-name>
<meta-value>Perinatal Psychiatry</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro">
<label>1</label>
<title>Introduction</title>
<p>Pregnant women frequently experience psychiatric symptoms such as anxiety and depression during gestation, attributable to physiological adaptations, psychological stressors, and evolving familial/social roles (<xref ref-type="bibr" rid="B1">1</xref>). While the postpartum period has traditionally dominated research on maternal mental health (<xref ref-type="bibr" rid="B2">2</xref>), emerging evidence identifies that prenatal depression is a potent predictor of postpartum depression and is a more prevalent condition (<xref ref-type="bibr" rid="B3">3</xref>), with estimated prevalence rates of 7-20% in high-income countries and &#x2265;20% in low- and middle-income nations (<xref ref-type="bibr" rid="B4">4</xref>). This condition is linked to adverse pregnancy outcomes, with long-term consequences extending into childhood and adulthood (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B6">6</xref>). Notably, expectant fathers also face underrecognized emotional challenges during his wife&#x2019;s pregnancy, including childbirth-related anxieties, and ambivalence toward pregnancy, which may precipitate depressive symptoms (<xref ref-type="bibr" rid="B7">7</xref>). A meta-analysis revealed a 9.76% prevalence of paternal prenatal depression throughout pregnancy, peaking at 13.59% during early gestation (<xref ref-type="bibr" rid="B8">8</xref>). Crucially, paternal depression negatively impacts maternal mental health and indirectly affects fetal/neonatal outcomes (<xref ref-type="bibr" rid="B9">9</xref>). The stress-depression nexus is well-established in epidemiological research (<xref ref-type="bibr" rid="B10">10</xref>), with substantial evidence linking prenatal stress exposure to elevated prenatal depression risk (<xref ref-type="bibr" rid="B11">11</xref>). However, existing research predominantly examines pregnant women individually, neglecting the dyadic relationships within couples.</p>
<p>The Actor-Partner Interdependence Model (APIM), introduced by Kenny and Cook (<xref ref-type="bibr" rid="B12">12</xref>), serves as the gold standard for dyadic data analysis (<xref ref-type="fig" rid="f1">
<bold>Figure&#xa0;1</bold>
</xref>). This framework accounts for dyadic data non-independence and has become an established method in marital, familial, and behavioral research (<xref ref-type="bibr" rid="B13">13</xref>). The APIM partitions relational effects into actor effects (<italic>a</italic>), where predictors influence one&#x2019;s own outcomes, and partner effects (<italic>p</italic>), where predictors affect a partner&#x2019;s outcomes (<xref ref-type="bibr" rid="B14">14</xref>). Building on this framework, Kenny et&#xa0;al. (<xref ref-type="bibr" rid="B15">15</xref>) delineated four interaction patterns: (1) actor-only (<italic>a</italic>&#x2260;0, <italic>p</italic>=0: self-predictors exclusively impact personal outcomes), (2) partner-only (<italic>a</italic>=0, <italic>p</italic>&#x2260;0: predictors solely influence partner outcomes), (3) couple-oriented (<italic>a</italic>=<italic>p</italic>: bidirectional equivalent effects), and (4) contrast (<italic>a</italic>=&#x2212;<italic>p</italic>: opposing self/partner predictive directions).</p>
<fig id="f1" position="float">
<label>Figure&#xa0;1</label>
<caption>
<p>The actor-partner interdependence model. <italic>X</italic>
<sub>1</sub> /<italic>X</italic>
<sub>2</sub>, <italic>Y</italic>
<sub>1</sub> /<italic>Y</italic>
<sub>2</sub> = measured variables; <italic>E</italic>
<sub>1</sub> /<italic>E</italic>
<sub>2</sub> = error terms; <italic>a</italic>= actor effect; <italic>p</italic> = partner effect; <italic>c</italic>
<sub>1</sub> /<italic>c</italic>
<sub>2</sub> = correlated residuals.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1607470-g001.tif">
<alt-text content-type="machine-generated">Diagram illustrating a system with variables and processes. Square nodes X1 and X2 connect to square nodes Y1 and Y2 respectively with arcs labeled a1, a2, and arrows labeled p12, p21 crossing between them. Circular nodes E1 and E2 connect back to Y1 and Y2 with arrows labeled '1'. Curved arrows labeled c1 and c2 connect E1 to X1 and E2 to X2, respectively.</alt-text>
</graphic>
</fig>
<p>Family system theory proposed that family relationships and dynamics are interactive, and each of the relationships is depending on each other (<xref ref-type="bibr" rid="B16">16</xref>). This fits perfectly with APIM&#x2019;s assumption. Besides, Stress can be considered a dyadic phenomenon- one&#x2019;s external stress can affect not only one&#x2019;s own perceived relationship stress (actor effects) but also the other partner&#x2019;s perceived relationship stress (partner effect) (<xref ref-type="bibr" rid="B17">17</xref>). This interpersonal transmission mechanism renders stress uniquely suited for analysis via APIM. Thus, this study examines whether partners&#x2019; prenatal stress exhibits cross-spousal influences on depression development using APIM, aiming to identify predominant dyadic effect patterns. The findings will provide empirical evidence to guide targeted interventions for enhancing dual-partner prenatal mental health.</p>
</sec>
<sec id="s2" sec-type="materials|methods">
<label>2</label>
<title>Materials and methods</title>
<sec id="s2_1">
<label>2.1</label>
<title>Study design</title>
<p>This cross-sectional study applied the Actor-Partner Interdependence Model (APIM) to determine the pattern of action of prenatal stress on prenatal depression between couples by calculating the ratio <italic>k</italic> of the partner effect to the actor effect.</p>
</sec>
<sec id="s2_2">
<label>2.2</label>
<title>Participants</title>
<p>A convenience sample of 340 couples meeting inclusion criteria was recruited from Provincial Maternal and Child Health Hospital, China (December 2023-April 2024). Pregnant women&#x2019;s electronic medical record data were sourced from this hospital. Eligibility required: gestational age &#x2265;28 weeks; absence of mental health diagnoses; survey comprehension capacity; and voluntary participation. Exclusion criteria included: incomplete data submission; withdrawal of consent; severe physical/mental conditions preventing independent participation; and communication barriers. From the 335 pregnant women and 296 spouses who completed surveys, 282 valid couple-dyad questionnaires were retained after excluding invalid responses, yielding an 82.74% validity rate. The study obtained written informed consent from all participants.</p>
<p>Following eligibility screening and informed consent, trained researchers detailed the study objectives and procedures. Participants completed self-administered questionnaires on-site under direct supervision. Spouses completed questionnaires independently in separate rooms without communication, with immediate collection upon completion to ensure data integrity. We emphasized anonymity and confidentiality throughout, enabling participants to express feelings freely and enhancing data reliability.</p>
</sec>
<sec id="s2_3">
<label>2.3</label>
<title>Measures</title>
<sec id="s2_3_1">
<label>2.3.1</label>
<title>General information questionnaire</title>
<p>A structured socio-demographic questionnaire was developed through literature synthesis aligned with study objectives, capturing key variables including gender, age, employment status, and gestational age.</p>
</sec>
<sec id="s2_3_2">
<label>2.3.2</label>
<title>Prenatal stress</title>
<p>The 14-item Perceived Stress Scale (PSS-14) (<xref ref-type="bibr" rid="B18">18</xref>), cross-culturally adapted for Chinese populations (<xref ref-type="bibr" rid="B19">19</xref>) was utilized to measure psychological stress. Responses were recorded on a 5-point Likert scale (0=never to 4=very often), with positive subscale items reverse-scored. Total scores range from 0 to 56, with higher scores indicating greater perceived stress (<xref ref-type="bibr" rid="B20">20</xref>). In this study, the Chinese PSS-14 demonstrated strong reliability in this cohort (Cronbach&#x2019;s &#x3b1;=0.81 pregnant women, 0.85 partners).</p>
</sec>
<sec id="s2_3_3">
<label>2.3.3</label>
<title>Prenatal depression</title>
<p>Depressive symptoms were assessed using the Chinese version of the Edinburgh Postnatal Depression Scale (EPDS) (<xref ref-type="bibr" rid="B21">21</xref>), a validated 10-item self-report measure for perinatal populations. Items evaluate symptom severity on a 4-point scale (0-3), yielding total scores 0&#x2013;30 with higher scores indicating more severe antenatal depression (clinical cutoff &#x2265;10) (<xref ref-type="bibr" rid="B22">22</xref>) The instrument showed excellent internal consistency in this study (Cronbach&#x2019;s &#x3b1;=0.82 pregnant women, 0.85 partners).</p>
</sec>
</sec>
<sec id="s2_4">
<label>2.4</label>
<title>Statistical methods</title>
<sec id="s2_4_1">
<label>2.4.1</label>
<title>Distinguishable and indistinguishable dyadic data</title>
<p>Dyads are distinguishable when partners have unique roles (e.g., pregnant woman vs. spouse) and indistinguishable without systematic role differentiation. We simultaneously fit two nested models: an unconstrained (saturated) model allowing actor and partner effects to vary freely across partners, and a constrained model equating actor and partner effects. A likelihood ratio test for model comparison produced chi-square and p-values. When <italic>P</italic> &#x2265; 0.2, indistinguishability is confirmed and the constrained model retained; when <italic>P</italic> &lt; 0.2, distinguishability is confirmed and the unconstrained model adopted (<xref ref-type="bibr" rid="B15">15</xref>).</p>
</sec>
<sec id="s2_4_2">
<label>2.4.2</label>
<title>Definition, estimation, and confidence intervals of the ratio <italic>k</italic>
</title>
<p>Kenny et&#xa0;al. proposed an APIM method testing dyadic patterns using ratio <italic>k</italic> (partner effect/actor effect; <italic>k</italic> = <italic>p</italic>/<italic>a</italic>) (<xref ref-type="bibr" rid="B23">23</xref>). Indistinguishable dyads yield one <italic>k</italic> value (<italic>p<sub>12</sub>
</italic>/<italic>a<sub>1</sub>
</italic> or <italic>p<sub>21</sub>
</italic>/<italic>a<sub>2</sub>
</italic>), while distinguishable dyads yield two values of <italic>k<sub>1</sub>
</italic>(<italic>k<sub>1</sub>
</italic> = <italic>p<sub>12</sub>
</italic>/<italic>a<sub>1</sub>
</italic>) and <italic>k<sub>2</sub>
</italic> (<italic>k<sub>2</sub>
</italic> = <italic>p<sub>21</sub>
</italic>/<italic>a<sub>2</sub>
</italic>). To avoid division by zero and unstable estimates when actor effects are small, <italic>k</italic> should not be calculated if the standardized |<italic>a</italic>| &lt; 0.10 (<xref ref-type="bibr" rid="B15">15</xref>). Critical <italic>k</italic> values are -1, 0, and 1 (<xref ref-type="bibr" rid="B24">24</xref>). Within the APIM framework, <italic>k</italic> and its confidence intervals (<italic>CIs</italic>) are directly estimable through phantom variables (<italic>P</italic>
<sub>1</sub> , <italic>P</italic>
<sub>2</sub>)&#x2014;latent constructs that preserve model fit (<xref ref-type="bibr" rid="B25">25</xref>). Mplus implementation (<xref ref-type="fig" rid="f2">
<bold>Figure&#xa0;2</bold>
</xref>) outputs <italic>k<sub>1</sub>
</italic>/<italic>k<sub>2</sub>
</italic> and <italic>CIs</italic> via predefined pathways.</p>
<fig id="f2" position="float">
<label>Figure&#xa0;2</label>
<caption>
<p>The APIM model with phantom variables. <italic>P</italic>
<sub>1</sub> /<italic>P</italic>
<sub>2</sub> = phantom variables for <italic>k<sub>1</sub>
</italic>/<italic>k<sub>2</sub>
</italic> estimation; <italic>X</italic>
<sub>1</sub> /<italic>X</italic>
<sub>2</sub>, <italic>Y</italic>
<sub>1</sub> /<italic>Y</italic>
<sub>2</sub> = measured variables; <italic>E</italic>
<sub>1</sub> /<italic>E</italic>
<sub>2</sub> = error terms; <italic>a</italic>= actor effect; <italic>p</italic> = partner effect; <italic>c</italic>
<sub>1</sub> /<italic>c</italic>
<sub>2</sub> = correlated residuals.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1607470-g002.tif">
<alt-text content-type="machine-generated">Diagram illustrating a system with variables and processes. Square nodes X1 and X2 connect to square nodes Y1 and Y2 respectively with arcs labeled a1, a2, and arrows labeled p12, p21 crossing between them. Circular nodes E1 and E2 connect back to Y1 and Y2 with arrows labeled '1'. Curved arrows labeled c1 and c2 connect E1 to X1 and E2 to X2, respectively.</alt-text>
</graphic>
</fig>
</sec>
<sec id="s2_4_3">
<label>2.4.3</label>
<title>Pattern analysis steps</title>
<p>Given partner-only configurations&#x2019; empirical rarity (<xref ref-type="bibr" rid="B26">26</xref>), analysis focused on actor-only, couple-oriented, and contrast patterns. Four sequential steps were implemented: first, estimating a saturated APIM to obtain actor (<italic>a<sub>1</sub>
</italic>, <italic>a<sub>2</sub>
</italic>) and partner effects (<italic>p<sub>21</sub>
</italic>, <italic>p<sub>12</sub>
</italic>); Second, testing actor effect equality (<italic>a<sub>1</sub>
</italic> = <italic>a<sub>2</sub>
</italic>) and partner effect equality (<italic>p<sub>21</sub>
</italic> = <italic>p<sub>12</sub>
</italic>). Dyadic data were treated as indistinguishable when <italic>P</italic> &#x2265; 0.2 (effects equal) or distinguishable when <italic>P</italic> &lt; 0.2 (effects unequal); Third, calculating <italic>k<sub>1</sub>
</italic> and <italic>k<sub>2</sub>
</italic> separately via phantom variables. For distinguishable dyads, <italic>k<sub>1</sub>
</italic> and <italic>k<sub>2</sub>
</italic> equality was tested; non-significant differences warranted using a single <italic>k</italic>; Finally, Calculating <italic>k</italic>&#x2019;s confidence interval (<italic>CI</italic>) and evaluating model fit to determine dyadic pattern: If <italic>CI</italic> included 0 but excluded &#xb1;1, <italic>k</italic> was constrained to 0 and the model re-estimated. Adequate fit indicated actor-/partner-only pattern; poor fit rejected both; If <italic>CI</italic> included 1 or -1, model fit determined support for couple-oriented or contrast patterns. For distinguishable dyads with equal <italic>k</italic> values, a common <italic>k</italic>&#x2019;s <italic>CI</italic> determined the specific dyadic pattern (<xref ref-type="bibr" rid="B27">27</xref>) (<xref ref-type="fig" rid="f3">
<bold>Figure&#xa0;3</bold>
</xref>).</p>
<fig id="f3" position="float">
<label>Figure&#xa0;3</label>
<caption>
<p>The flowchart illustrates the process of analysis of dyadic patterns within an APIM model using the Mplus. Excludes partner-only pattern due to low observed frequency.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1607470-g003.tif">
<alt-text content-type="machine-generated">Flowchart assessing whether dyadic data are distinguishable. It progresses to estimation of a saturated Actor-Partner Interdependence Model (APIM), examining actor and partner effects. Inequivalent effects lead to a phantom variable APIM model. Distinguishable data may analyze single or multiple k values, whereas indistinguishable data proceed directly to testing. The final step involves confidence interval examination to determine support for a dyadic pattern.</alt-text>
</graphic>
</fig>
</sec>
<sec id="s2_4_4">
<label>2.4.4</label>
<title>Statistical analysis</title>
<p>Analyses were conducted using SPSS 26.0, Mplus 8.3 and R 4.5.0, with statistical significance set at <italic>P</italic> &lt; 0.05. Continuous variables were expressed as medians (interquartile ranges) and categorical variables as frequencies (%). Differences in demographics, prenatal stress, and depression were assessed via wilcoxon signed ranks test and &#x3c7;&#xb2; tests. Internal consistency was evaluated using Cronbach&#x2019;s &#x3b1;, while Pearson correlations examined prenatal stress-depression associations. Sensitivity analysis was performed using multiple imputation methods to assess the impact of missing data. Generalized linear models incorporating a stress-by-gender interaction term were employed to examine gender differences in the stress-depression relationship among pregnant women and their partners.</p>
<p>Structural equation modeling employed robust maximum likelihood estimation with 5,000 bootstrap iterations to calculate 95% <italic>Cis</italic>. Model fit was evaluated using multiple criteria: &#x3c7;&#xb2;/<italic>df</italic> ratio &lt; 3, comparative fit index (CFI) &#x2265; 0.90, root mean square error of approximation (RMSEA) &#x2264; 0.08, standardized root mean square residual (SRMR) &#x2264; 0.08, and Tucker-Lewis index (TLI) &#x2265; 0.90 (<xref ref-type="bibr" rid="B28">28</xref>, <xref ref-type="bibr" rid="B29">29</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s3" sec-type="results">
<label>3</label>
<title>Results</title>
<sec id="s3_1">
<label>3.1</label>
<title>Demographic features of the participants</title>
<p>The sample comprised 282 couples with pregnant women averaging 31 years (mean gestation=39 weeks) and husbands averaging 33 years. Among pregnant women, those with undergraduate education constituted the highest proportion (37.9%). Pregnant women demonstrated higher prenatal stress scores and depression prevalence than husbands. Significant gender disparities emerged in both prenatal stress and depression levels (<xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>). Following data interpolation, a sensitivity analysis was conducted, which demonstrated
robust results (<xref ref-type="supplementary-material" rid="SM1">
<bold>Supplementary Table&#xa0;1</bold>
</xref>).</p>
<table-wrap id="T1" position="float">
<label>Table&#xa0;1</label>
<caption>
<p>Descriptive characteristics of the participants (N = 282).</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="middle" align="center">Variables</th>
<th valign="middle" align="center">Total (N=564)</th>
<th valign="middle" align="center">Pregnant women (N=282)</th>
<th valign="middle" align="center">Husbands (N=282)</th>
<th valign="middle" align="center">
<italic>Z</italic>/<italic>&#x3c7;<sup>2</sup>
</italic>
</th>
<th valign="middle" align="center">
<italic>P</italic> value</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="center">32 (29,35)</td>
<td valign="middle" align="center">31 (28,34)</td>
<td valign="middle" align="center">33 (30,36)</td>
<td valign="middle" align="center">10.105</td>
<td valign="middle" align="center">
<bold>&lt; 0.001</bold><xref ref-type="table-fn" rid="fnT1_1">
<sup>a</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>Prenatal stress</bold>
</td>
<td valign="middle" align="center">24 (17,28)</td>
<td valign="middle" align="center">24 (18,28)</td>
<td valign="middle" align="center">22 (17,28)</td>
<td valign="middle" align="center">-2.038</td>
<td valign="middle" align="center">
<bold>0.042</bold><xref ref-type="table-fn" rid="fnT1_1">
<sup>a</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>Gestation week</bold>
</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center">39 (38,39)</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<th valign="middle" colspan="6" align="left">
Education
</th>
</tr>
<tr>
<td valign="middle" align="center">Below High School Level</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center">41 (7.270)</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="center">Undergraduate</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center">214 (37.943)</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="center">Graduate</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center">17 (4.787)</td>
<td valign="middle" align="center">-</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">
<bold>Prenatal depression</bold>
</td>
<td valign="middle" align="center">4 (1,2)</td>
<td valign="middle" align="center">5 (2,9)</td>
<td valign="middle" align="center">4 (1,6)</td>
<td valign="middle" align="center">-3.477</td>
<td valign="middle" align="center">
<bold>0.001</bold><xref ref-type="table-fn" rid="fnT1_1">
<sup>a</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="left"/>
<td valign="middle" colspan="3" align="center"/>
<td valign="middle" align="center">7.058</td>
<td valign="middle" align="center">
<bold>0.008</bold><xref ref-type="table-fn" rid="fnT1_2">
<sup>b</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="center">Depressed</td>
<td valign="middle" align="center">89 (15.780)</td>
<td valign="middle" align="center">56 (19.858)</td>
<td valign="middle" align="center">33 (11.702)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="center">Not Depressed</td>
<td valign="middle" align="center">475 (84.220)</td>
<td valign="middle" align="center">226 (80.142)</td>
<td valign="middle" align="center">249 (88.230)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">
<bold>Occupation</bold>
</td>
<td valign="middle" colspan="3" align="center"/>
<td valign="middle" align="center">5.064</td>
<td valign="middle" align="center">
<bold>0.024</bold>
<xref ref-type="table-fn" rid="fnT1_2">
<sup>b</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="center">with occupation</td>
<td valign="middle" align="center">539 (95.567)</td>
<td valign="middle" align="center">264 (93.617)</td>
<td valign="middle" align="center">275 (97.518)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="center">without occupation</td>
<td valign="middle" align="center">25 (4.433)</td>
<td valign="middle" align="center">18 (6.383)</td>
<td valign="middle" align="center">7 (2.482)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">
<bold>Family history of hypertension</bold>
</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
<td valign="middle" align="center">0.002</td>
<td valign="middle" align="center">0.968<xref ref-type="table-fn" rid="fnT1_2">
<sup>b</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="center">Yes</td>
<td valign="middle" align="center">104 (18.440)</td>
<td valign="middle" align="center">52 (18.571)</td>
<td valign="middle" align="center">52 (18.440)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="center">No</td>
<td valign="middle" align="center">458 (81.206)</td>
<td valign="middle" align="center">228 (81.429)</td>
<td valign="middle" align="center">230 (81.560)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">
<bold>Family history of diabetes</bold>
</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
<td valign="middle" align="center">0.744</td>
<td valign="middle" align="center">0.388<xref ref-type="table-fn" rid="fnT1_2">
<sup>b</sup>
</xref>
</td>
</tr>
<tr>
<td valign="middle" align="center">Yes</td>
<td valign="middle" align="center">50 (8.865)</td>
<td valign="middle" align="center">28 (9.964)</td>
<td valign="middle" align="center">22 (7.885)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="center">No</td>
<td valign="middle" align="center">510 (90.426)</td>
<td valign="middle" align="center">253 (90.036)</td>
<td valign="middle" align="center">257 (92.115)</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="fnT1_1">
<label>a</label>
<p>Comparisons between groups were made using wilcoxon signed ranks test and are presented as P<sub>50</sub> (P<sub>25</sub>, P<sub>75</sub>);</p>
</fn>
<fn id="fnT1_2">
<label>b</label>
<p>Comparisons between groups were made using the &#x3c7;&#xb2; test, and and are presented as frequencies (%). There are missing values for family history of hypertension and diabetes, with 2 and 4 cases missing.</p>
</fn>
<fn>
<p>The bold values indicate statistical significance (<italic>P</italic>&lt;0.05).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3_2">
<label>3.2</label>
<title>Correlation analysis of variables</title>
<p>The results indicated significant positive correlations between prenatal stress and prenatal depression in both individuals and their partners. Specifically, pregnant women&#x2019;s and, husbands&#x2019; stress levels correlated with their own depression and their partners&#x2019; depression (<xref ref-type="table" rid="T2">
<bold>Table&#xa0;2</bold>
</xref>).</p>
<table-wrap id="T2" position="float">
<label>Table&#xa0;2</label>
<caption>
<p>Correlational analysis of prenatal stress and prenatal depression in couples (N = 282).</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="middle" align="center">Variables</th>
<th valign="middle" align="center">Prenatal stress in pregnant women</th>
<th valign="middle" align="center">Prenatal stress in husbands</th>
<th valign="middle" align="center">Prenatal depression in pregnant women</th>
<th valign="middle" align="center">Prenatal depression in husbands</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">Prenatal stress in pregnant women</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">Prenatal stress in husbands</td>
<td valign="middle" align="center">0.212<sup>**</sup>
</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center"/>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">Prenatal depression in pregnant women</td>
<td valign="middle" align="center">0.629<sup>**</sup>
</td>
<td valign="middle" align="center">0.168<sup>**</sup>
</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center"/>
</tr>
<tr>
<td valign="middle" align="left">Prenatal depression in husbands</td>
<td valign="middle" align="center">0.132*</td>
<td valign="middle" align="center">0.482<sup>**</sup>
</td>
<td valign="middle" align="center">0.208<sup>**</sup>
</td>
<td valign="middle" align="center">1</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>*<italic>P</italic>&lt; 0.05, **<italic>P</italic> &lt; 0.01.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3_3">
<label>3.3</label>
<title>APIM analyses</title>
<sec id="s3_3_1">
<label>3.3.1</label>
<title>The fitness index of APIM model</title>
<p>Analysis commenced with a saturated APIM. Constraining two actor and two partner effects revealed significant between-couple path discrepancies (<italic>P</italic> &lt; 0.20), establishing dyadic distinguishability. Phantom variable integration yielded <italic>k<sub>1</sub>
</italic> and <italic>k<sub>2</sub>
</italic> estimates with 95% CIs encompassing zero. Parameter fixation (<italic>k<sub>1</sub>
</italic> = <italic>k<sub>2</sub>
</italic> = 0) produced a well-fitting model demonstrating excellent conformity: &#x3c7;&#xb2;/<italic>df</italic>=1.423, SRMR=0.016, CFI=1.000, TLI=1.012, RMSEA=0.000, all meeting established thresholds (<xref ref-type="table" rid="T3">
<bold>Table&#xa0;3</bold>
</xref>).</p>
<table-wrap id="T3" position="float">
<label>Table&#xa0;3</label>
<caption>
<p>The APIM model fit index.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="middle" align="center">Model</th>
<th valign="middle" align="center">
<italic>df</italic>
</th>
<th valign="middle" align="center">
<italic>&#x3c7;<sup>2</sup>
</italic>
</th>
<th valign="middle" align="center">
<italic>&#x3c7;<sup>2</sup>
</italic>/<italic>df</italic>
</th>
<th valign="middle" align="center">SRMR</th>
<th valign="middle" align="center">RMSEA</th>
<th valign="middle" align="center">TLI</th>
<th valign="middle" align="center">CFI</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left">Saturated APIM model</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">1.000</td>
<td valign="middle" align="center">1.000</td>
</tr>
<tr>
<td valign="middle" align="left">Phantom variables APIM model</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">1.000</td>
<td valign="middle" align="center">1.000</td>
</tr>
<tr>
<td valign="middle" align="left">APIM model with a fixed k value of 0</td>
<td valign="middle" align="center">2,000</td>
<td valign="middle" align="center">0.949</td>
<td valign="middle" align="center">0.475</td>
<td valign="middle" align="center">0.016</td>
<td valign="middle" align="center">0.000</td>
<td valign="middle" align="center">1.012</td>
<td valign="middle" align="center">1.000</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>
<italic>df</italic>, degree of freedom; <italic>&#x3c7;<sup>2</sup>
</italic>, chi-square; SRMR, standardized root mean square residual; CFI, comparative fit index; TLI, tucker lewis index; RMSEA, root mean square error of approximation.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3_3_2">
<label>3.3.2</label>
<title>The APIM analysis of prenatal stress and prenatal depression in couples</title>
<p>
<xref ref-type="fig" rid="f4">
<bold>Figure&#xa0;4</bold>
</xref> presents the constrained model with effect values detailed in <xref ref-type="table" rid="T4">
<bold>Table&#xa0;4</bold>
</xref>. The analysis revealed <italic>k<sub>1</sub>
</italic> = 0.064, 95% <italic>CI:</italic> (-0.113, 0.260) and <italic>k<sub>2</sub>
</italic> = 0.064, 95% <italic>CI</italic>: (-0.118, 0.249). The confidence intervals for both <italic>k<sub>1</sub>
</italic> and <italic>k<sub>2</sub>
</italic> included zero, indicating an actor-only pattern in the APIM. Specifically, prenatal stress positively predicted one&#x2019;s own prenatal depression but did not significantly influence the partner&#x2019;s depression.</p>
<fig id="f4" position="float">
<label>Figure&#xa0;4</label>
<caption>
<p>the results of the APIM of prenatal stress and prenatal depression in couples (N=282). *<italic>P</italic>&lt; 0.05, **<italic>P</italic> &lt; 0.01, ***<italic>P</italic> &lt; 0.001.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-16-1607470-g004.tif">
<alt-text content-type="machine-generated">Path analysis diagram illustrating relationships between prenatal stress and depression in pregnant women and their husbands. Arrows show interactions, with coefficients: 0.367, 0.293, 0.024, and 0.017. Circles labeled E1 and E2 represent error terms with values 1.964 and 10.502, respectively.</alt-text>
</graphic>
</fig>
<table-wrap id="T4" position="float">
<label>Table&#xa0;4</label>
<caption>
<p>The results of effect estimation and k values in APIM during couples.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="top" align="center"/>
<th valign="top" align="center">Actor effect</th>
<th valign="top" align="center">
<italic>P</italic> value</th>
<th valign="top" align="center">Partner effect</th>
<th valign="top" align="center">
<italic>P</italic> value</th>
<th valign="top" align="center">
<italic>k</italic> value</th>
<th valign="top" align="center">95% <italic>CI</italic>
</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="center">Pregnant women</td>
<td valign="top" align="center">0.367</td>
<td valign="top" align="center">&lt;0.001</td>
<td valign="top" align="center">0.017</td>
<td valign="top" align="center">0.482</td>
<td valign="top" align="center">0.064</td>
<td valign="top" align="center">[-0.113, 0.260]</td>
</tr>
<tr>
<td valign="top" align="center">Husbands</td>
<td valign="top" align="center">0.293</td>
<td valign="top" align="center">&lt;0.001</td>
<td valign="top" align="center">0.024</td>
<td valign="top" align="center">0.520</td>
<td valign="top" align="center">0.059</td>
<td valign="top" align="center">[-0.118, 0.249]</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>
<italic>k</italic>=<italic>p</italic>/<italic>a</italic>, where <italic>a</italic> represents the actor effect and <italic>p</italic> represents the partner effect.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<p>At the same time individual prenatal stress had a statistically significant positive effect on prenatal depression (<italic>&#x3b2;</italic> = 0.367, <italic>P</italic> &lt; 0.001; <italic>&#x3b2;</italic> = 0.293, <italic>P</italic> &lt; 0.001), and no effect on partner prenatal depression (<italic>&#x3b2;</italic> = 0.024, <italic>P</italic> = 0.482; <italic>&#x3b2;</italic> = 0.017, <italic>P</italic> = 0.520). Specifically, an elevated risk of prenatal depression was observed in both pregnant women and their husbands as prenatal stress levels increased.</p>
<p>To investigate gender differences in the stress-depression relationship among pregnant women and
their partners, a generalized linear model incorporating a stress-by-gender interaction term was employed. The interaction term did not attain statistical significance (<italic>&#x3b2;</italic> = 0.074, <italic>P</italic> = 0.081), indicating no evidence for gender moderation of the stress-depression relationship within partner dyads (<xref ref-type="supplementary-material" rid="SM2">
<bold>Supplementary Table&#xa0;2</bold>
</xref>).</p>
</sec>
</sec>
</sec>
<sec id="s4" sec-type="discussion">
<label>4</label>
<title>Discussion</title>
<p>This study demonstrated elevated prenatal depression prevalence, with 20% among pregnant women exceeding international reports (7.4-12.8%) (<xref ref-type="bibr" rid="B30">30</xref>) yet aligning with domestic studies (3.6-40.2%) (<xref ref-type="bibr" rid="B31">31</xref>&#x2013;<xref ref-type="bibr" rid="B33">33</xref>). And 12% among expectant fathers, higher than meta-analytic estimates (9.8%) (<xref ref-type="bibr" rid="B8">8</xref>). These cross-study discrepancies likely reflect methodological heterogeneity in screening tools, and population characteristics. Notably, this study revealed significant gender disparities in prenatal stress and depression among expectant parents. Pregnant women demonstrated markedly higher prenatal stress scores and a greater prevalence of prenatal depression compared to their husbands, aligning with previous research findings (<xref ref-type="bibr" rid="B34">34</xref>). The observed gender gradient may stem from synergistic mechanisms: physiological adaptations (gestational changes) (<xref ref-type="bibr" rid="B35">35</xref>), psychosocial stressors (role transitions) (<xref ref-type="bibr" rid="B36">36</xref>), and neurocognitive factors (enhanced emotional recall influencing symptom reporting) (<xref ref-type="bibr" rid="B37">37</xref>), collectively amplifying stress-depression associations (<xref ref-type="bibr" rid="B8">8</xref>). These findings underscore the necessity for gender-specific mental health interventions during perinatal care.</p>
<p>The present cross-sectional study investigated the APIM of prenatal stress and depression within couples, revealing an actor-only pattern. Specifically, individual prenatal stress influences only one&#x2019;s own prenatal depression, without affecting the spouse&#x2019;s. Notably, higher maternal and spousal stress as a risk factor for individual prenatal depression, aligning with previous research (<xref ref-type="bibr" rid="B38">38</xref>). Stress may lead to depression via mechanisms such as hypothalamic-pituitary-adrenal (HPA) axis dysregulation (<xref ref-type="bibr" rid="B39">39</xref>), neurotransmitter imbalances (<xref ref-type="bibr" rid="B40">40</xref>), neurotrophic factor inhibition (<xref ref-type="bibr" rid="B41">41</xref>). Consequently, maintaining a positive attitude and managing stress effectively are crucial for both pregnant women and their partners to reduce the risk of prenatal depression.</p>
<p>Family systems theory posits that individuals&#x2019; mental health is influenced by family interactions and emotional bonds (<xref ref-type="bibr" rid="B16">16</xref>). Notably the study did not detect a significant impact of individual prenatal stress on spouses&#x2019; prenatal depression, a finding that might stem from traditional Chinese gender - role expectations. In traditional Chinese culture, men are typically seen as the breadwinners, while women are expected to manage domestic matters. These roles can shape different perceptions, emotional reactions, and coping mechanisms when couples encounter stress (<xref ref-type="bibr" rid="B42">42</xref>), potentially explaining the lack of partner pattern. Adjusting gender - role attitudes may enhance couples&#x2019; ability to handle prenatal stress (<xref ref-type="bibr" rid="B43">43</xref>). Moreover, collectivism and family harmony are central to Chinese culture, deeply influencing couples&#x2019; interactions (<xref ref-type="bibr" rid="B44">44</xref>). To preserve harmony, couples might suppress negative emotions and deal with stress independently instead of turning to their partners, leading to less emotional sharing and weakened mutual support (<xref ref-type="bibr" rid="B45">45</xref>). Finally, pervasive mental health stigma (<xref ref-type="bibr" rid="B46">46</xref>) may further reinforces this tendency. Future research could explore these cultural dynamics more deeply to better understand their impact on couple interactions and stress management.</p>
<p>Currently, there is a scarcity of studies, both domestically and internationally, that explore the correlation between prenatal stress and prenatal depression within the context of couples. Utilizing dichotomous dyadic couple data and the latest APIM, this study revealed an actor-only pattern for prenatal stress and depression within relationships. Consequently, we recommend that healthcare providers concurrently implement standardized psychological screening (e.g., PSS, PHQ-9, EPDS) for both expectant mothers and fathers during routine prenatal visits to enable early detection of significant stress or depression risk in either partner. Practical tips for couples to cope with stress together should also be integrated into prenatal education programmes and partner counselling to improve the ability of couples to communicate about their feelings of stress and solve problems together. In addition, individualised psychological support should be provided to either partner with emotional distress, such as cognitive behavioural therapy to help them adjust their negative thinking. These strategies mitigate parental psychological distress, reduce prenatal depression risk, and ultimately enhance pregnancy and postnatal outcomes.</p>
<p>However, several limitations should be acknowledged in this study. Although anonymous surveys, confidentiality protocols, and reliable self-administered scales were implemented, recall and social desirability biases remain unavoidable. Future research should incorporate objective measures (e.g., cortisol levels) to validate self-reports. The cross-sectional nature of the study precluded causal inferences and limited the assessment to the psychological state of couples in late pregnancy. Longitudinal study designs with regular data collection are recommended for future research to better capture the temporal evolution and interplay of stress and depression. Notably, the sample was drawn from a single hospital in Fuzhou City. While this hospital, undertaking most of Fuzhou&#x2019;s maternal deliveries, partially reflects the mental health of local pregnant women, the findings may not generalize to pregnant populations in other geographic, socioeconomic, or healthcare settings. Future studies should diversify recruitment regions to enhance the generalizability of results.</p>
</sec>
<sec id="s5" sec-type="conclusions">
<label>5</label>
<title>Conclusion</title>
<p>Prenatal stress and prenatal depression in couple dyads fall within an actor-only pattern of the APIM, individual prenatal stress affects only one&#x2019;s own prenatal depression and not that of one&#x2019;s spouse. The higher the stress of the pregnant woman and her spouse, the higher the risk of individual prenatal depression. Healthcare professionals and family members should pay attention to the prenatal stress of pregnant women and their husbands at the same time, and reduce the couple&#x2019;s prenatal stress through comprehensive interventions, so as to prevent and alleviate the occurrence of prenatal depression in both partners, and to improve pregnancy outcomes and postnatal health.</p>
</sec>
</body>
<back>
<sec id="s6" sec-type="data-availability">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="s7" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>The studies involving humans were approved by the Fujian Maternal and Child Health Hospital Ethics Committee (Approval No. 2020KY117). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.</p>
</sec>
<sec id="s8" sec-type="author-contributions">
<title>Author contributions</title>
<p>XL: Data curation, Formal Analysis, Investigation, Methodology, Supervision, Writing &#x2013; original draft. YD: Data curation, Formal Analysis, Investigation, Methodology, Supervision, Writing &#x2013; original draft. JZ: Data curation, Formal Analysis, Investigation, Methodology, Supervision, Writing &#x2013; original draft. SYL: Data curation, Investigation, Methodology, Writing &#x2013; original draft. ML: Data curation, Investigation, Methodology, Writing &#x2013; original draft. HZ: Investigation, Methodology, Writing &#x2013; original draft. XZ: Investigation, Methodology, Writing &#x2013; original draft. YS: Investigation, Methodology, Writing &#x2013; original draft. XX: Methodology, Conceptualization, Writing &#x2013; review &amp; editing. QL: Methodology, Conceptualization, Writing &#x2013; review &amp; editing. SWL: Conceptualization, Methodology, Writing &#x2013; review &amp; editing. SW: Writing &#x2013; review &amp; editing, Conceptualization, Methodology.</p>
</sec>
<sec id="s9" sec-type="funding-information">
<title>Funding</title>
<p>The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported in part by the Fujian Province Financial Special Funds (23SCZZX007), Fujian provincial health technology project (2024GGA060).</p>
</sec>
<sec id="s10" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s11" sec-type="correction-note">
<title>Correction note</title>
<p>A correction has been made to this article. Details can be found at: <ext-link xlink:href="https://doi.org/10.3389/fpsyt.2025.1682329" ext-link-type="uri">10.3389/fpsyt.2025.1682329</ext-link>.</p>
</sec>
<sec id="s12" sec-type="ai-statement">
<title>Generative AI statement</title>
<p>The author(s) declare that no Generative AI was used in the creation of this manuscript.</p>
</sec>
<sec id="s13" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec id="s14" sec-type="supplementary-material">
<title>Supplementary material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1607470/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1607470/full#supplementary-material</ext-link>
</p>
<supplementary-material xlink:href="Table1.docx" id="SM1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document">
<label>Supplementary Table&#xa0;1</label>
<caption>
<p>Descriptive characteristics of the participants.</p>
</caption>
</supplementary-material>
<supplementary-material xlink:href="Table1.docx" id="SM2" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document">
<label>Supplementary Table&#xa0;2</label>
<caption>
<p>Gender differences in the stress-depression relationship in couples.</p>
</caption>
</supplementary-material>
</sec>
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