AUTHOR=Zhao Di , Liu Chunyu 

TITLE=Effects of paroxetine combined with sulpiride on sleep status and quality of life in patients with depressive episodes

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1600675

DOI=10.3389/fpsyt.2025.1600675

ISSN=1664-0640

ABSTRACT=ObjectiveAssess the clinical efficacy of paroxetine and sulpiride IV drip in treating depression and its impact on sleep and quality of life.MethodsRetrospective analysis of 80 depression patients, divided into a study group treated with paroxetine and sulpiride IV drip, and a control group treated with paroxetine alone, over 8 weeks. HAMD and SF-36 assessed depression and quality of life; TESS evaluated adverse reactions.ResultsHAMD scores decreased in both groups, with the study group showing better depression status at 1, 2, and 4 weeks (P<0.05) and higher effective rates (P<0.05). The study group had faster symptom relief. SF-36 scores in role physical, general health, vitality, and role emotional were higher in the study group (P<0.05). TESS scores showed no significant difference between groups (P>0.05), with mild adverse reactions.ConclusionParoxetine with sulpiride IV drip offers rapid relief and high safety in depression treatment, improving sleep and quality of life.