AUTHOR=Argyriou Evangelia , Prestigiacomo Christiana , Samuel Douglas B. , Stewart Jesse C. , Wu Wei , Cyders Melissa A. 

TITLE=Hierarchical taxonomy of psychopathology and personalized mental health treatment selection

JOURNAL=Frontiers in Psychiatry

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1597879

DOI=10.3389/fpsyt.2025.1597879

ISSN=1664-0640

ABSTRACT=Accumulated research has shown considerable heterogeneity in mental health treatment response. Precision mental health approaches aim to leverage this heterogeneity to tailor treatment selection to individual needs. The goals of this manuscript are to 1) present theoretical rationale for the potential usefulness of the Hierarchical Taxonomy of Psychopathology (HiTOP) to optimize treatment selection and 2) conduct a scoping review of the role of individual psychopathology components that map onto HiTOP on differential psychotherapy response, both as a proof-of-concept analysis, as well as to identify gaps and concrete recommendations for future application. We focus our review on treatment for internalizing disorders as a candidate class of disorders, and on Cognitive-Behavioral Therapies given their empirical support for this disorder class. Overall, the reviewed literature provides preliminary evidence about the potential usefulness of HiTOP dimensions of differing levels of specificity for personalized treatment selection that can guide future research. Gaps and limitations were identified, including limited research in several HiTOP domains, strict inclusion/exclusion criteria shrinking individual heterogeneity, large variability in HiTOP dimension measurement, risk of Type I and Type II error, and other methodological limitations for assessing personalized treatment response. The translation of this research to clinical decision making has a long way to go. Nonetheless, we view the application of HiTOP-relevant dimensions to personalized mental health approaches as a viable and exciting direction that offers many avenues for research for the improvement of patient outcomes.