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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2024.1390949</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Investigating the impact of acceptance and commitment therapy for mental healthcare professionals: the effect on patients&#xb4; self-stigmatization, a pilot study</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Helmus</surname>
<given-names>Kim L.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/579282"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van Doorn</surname>
<given-names>Marilon</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1012423"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>de Koning</surname>
<given-names>Mariken B.</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/2332360"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Myin-Germeys</surname>
<given-names>Inez</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/12990"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schirmbeck</surname>
<given-names>Frederike N.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1245481"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>van Amelsvoort</surname>
<given-names>Therese A. M. J.</given-names>
</name>
<xref ref-type="aff" rid="aff6">
<sup>6</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/275726"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nieman</surname>
<given-names>Dorien H.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/697183"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jaspers</surname>
<given-names>Monique W. M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff7">
<sup>7</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/supervision/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Popma</surname>
<given-names>Arne</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/supervision/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>de Haan</surname>
<given-names>Lieuwe</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/734793"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
</contrib-group>
<aff id="aff1">
<sup>1</sup>
<institution>Research Mental Health, Amsterdam Medical Centre</institution>, <addr-line>Amsterdam</addr-line>, <country>Netherlands</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Neurology and Psychiatry Department, Amsterdam Universitair Medisch Centrum</institution>, <addr-line>Amsterdam</addr-line>, <country>Netherlands</country>
</aff>
<aff id="aff3">
<sup>3</sup>
<institution>Severe Mental Health Care Department (Mentrum)</institution>, <addr-line>Arkin, Amsterdam</addr-line>, <country>Netherlands</country>
</aff>
<aff id="aff4">
<sup>4</sup>
<institution>Research Department</institution>, <addr-line>Arkin, Amsterdam</addr-line>, <country>Netherlands</country>
</aff>
<aff id="aff5">
<sup>5</sup>
<institution>Faculty of Medicine, Katholieke Universiteit Leuven</institution>, <addr-line>Kortrijk</addr-line>, <country>Belgium</country>
</aff>
<aff id="aff6">
<sup>6</sup>
<institution>Faculty Health, Medicine and Life Sciences, Maastricht University Medical Centre</institution>, <addr-line>Maastricht</addr-line>, <country>Netherlands</country>
</aff>
<aff id="aff7">
<sup>7</sup>
<institution>Department of Medical Informatics, Amsterdam Public Health Institute</institution>, <addr-line>Amsterdam</addr-line>, <country>Netherlands</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>Edited by: Gerard Hutchinson, University of the West Indies St. Augustine, Trinidad and Tobago</p>
</fn>
<fn fn-type="edited-by">
<p>Reviewed by: Julia Van Liew, Des Moines University, United States</p>
<p>Paul Flaxman, City University of London, United Kingdom</p>
</fn>
<fn fn-type="corresp" id="fn001">
<p>*Correspondence: Kim L. Helmus, <email xlink:href="mailto:kimlottehelmus@gmail.com">kimlottehelmus@gmail.com</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>07</day>
<month>01</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>15</volume>
<elocation-id>1390949</elocation-id>
<history>
<date date-type="received">
<day>24</day>
<month>02</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>11</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2025 Helmus, van Doorn, de Koning, Myin-Germeys, Schirmbeck, van Amelsvoort, Nieman, Jaspers, Popma and de Haan</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Helmus, van Doorn, de Koning, Myin-Germeys, Schirmbeck, van Amelsvoort, Nieman, Jaspers, Popma and de Haan</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>A significant proportion of mental health care professionals (MHCPs) hold stigmatizing attitudes about their patients. When patients perceive and internalize these beliefs, self-stigmatization can increase. Acceptance and Commitment Therapy (ACT) may decrease stigmatizing attitudes by changing the &#x2018;us&#x2019; versus &#x2018;them&#x2019; thinking into continuum beliefs. In the present study MHCPs were given an ACT-based training, aiming to decrease stigmatization, hypothesizing that self-stigmatization of their patients will subsequently decrease.</p>
</sec>
<sec>
<title>Methods</title>
<p>An RCT with a 2 (pre-test/post-test) x 2 (no training/training) design was conducted. A total of 41 MHCPs participated, 20 were randomized to the experimental and 21 to the control condition respectively. The MHCPs in the experimental condition received an ACT-based training, MHCPs in the control condition received no training. From every MHCP, one of their patients participated in the pre- and post-measurement. As the primary outcome, patients&#x2019; awareness, agreement, application and hurt-self, was measured using the Self Stigma of Mental Illness Scale - Short Form (SSMIS-SF), before and after the MHCPs&#x2019; ACT-based training.</p>
</sec>
<sec>
<title>Results</title>
<p>Significant group x time interaction effects were found for &#x2018;application&#x2019; (internalization of mental illness stereotypes) in patients after the ACT-based training of their MHCP: <italic>F</italic> (1,39) = 9.33, p &lt; 0.01, &#x3b7;<sub>p</sub>
<sup>2</sup> = .85. On the contrary, no effect was found on the subscales &#x2018;awareness&#x2019;, &#x2018;agreement&#x2019; and &#x2018;hurt-self&#x2019;.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Preliminary results suggest that a brief ACT training for MHCP might heighten their awareness and contribute to reduction of their stigmatizing attitudes and behavior, leading to less application of self-stigmatizing beliefs in their patients.</p>
</sec>
</abstract>
<kwd-group>
<kwd>self-stigmatization</kwd>
<kwd>acceptance and commitment therapy (act)</kwd>
<kwd>mental healthcare</kwd>
<kwd>professionals</kwd>
<kwd>stigma &amp; awareness</kwd>
</kwd-group>
<counts>
<fig-count count="5"/>
<table-count count="2"/>
<equation-count count="0"/>
<ref-count count="56"/>
<page-count count="9"/>
<word-count count="4457"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-in-acceptance</meta-name>
<meta-value>Social Psychiatry and Psychiatric Rehabilitation</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro">
<title>Introduction</title>
<p>Previously, severe mental illness was predominantly regarded as chronic and deteriorating. However, over recent years there has been a shift towards more recovery-oriented perspectives and approaches (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>) Numerous studies demonstrate that many individuals with severe mental illness achieve recovery in terms of symptomatology, (social) functioning or/and personal growth (<xref ref-type="bibr" rid="B3">3</xref>&#x2013;<xref ref-type="bibr" rid="B5">5</xref>). Despite the increasing acceptance and comprehension of these recovery-oriented approaches, the implementation and delivery of services continues to pose significant challenges (<xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B6">6</xref>).</p>
<p>The prevalence of stigmatization towards patients with severe mental health problems contributes to the challenges in implementing recovery-oriented approaches (<xref ref-type="bibr" rid="B7">7</xref>). Even though mental healthcare professionals (MHCPs) themselves do not always recognize having stigmatizing attitudes (<xref ref-type="bibr" rid="B8">8</xref>), stigmatization within mental healthcare remains common (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>). Disturbingly, over twenty percent of reported instances of stigmatization are attributed to encounters with MHCPs (<xref ref-type="bibr" rid="B10">10</xref>) even though attitudes of MHCPs seem overall more positive compared to the general public (<xref ref-type="bibr" rid="B11">11</xref>). One of the underlying causes can be a binary perspective held by some MHCPs, where mental health and mental illness are perceived as fundamentally distinct, leading to stereotypes and a separation of &#x2018;us&#x2019; versus &#x2018;them&#x2019;; seeing &#x2018;them&#x2019; as different from their own &#x2018;normal&#x2019; experiences and behavior. Stereotypes and beliefs can be implicit (i.e., beliefs that reside outside of conscious control and/or awareness; associations that one would not explicitly endorse or reveal) or explicit (beliefs that are self-reported and occur within conscious control and/or awareness). There is an increasing understanding that explicit measures may underestimate levels of stigmatization (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B13">13</xref>). Further, explicit and implicit measures may differentially predict behavioral outcomes due to operating through reflective (e.g., basing decisions on knowledge about facts and values) versus impulsive (e.g., basing decisions on associative links and motivational orientations) systems (<xref ref-type="bibr" rid="B14">14</xref>), or based on whether outcomes are controllable or spontaneous (<xref ref-type="bibr" rid="B15">15</xref>). Both implicit and explicit stereotypes and beliefs are associated with labeling, and can result in the marginalization and discrimination of a specific group. This categorical distinction plays a significant role in the stigmatization process (<xref ref-type="bibr" rid="B16">16</xref>). Stigmatization of individuals or groups with mental health problems involves perceiving, experiencing, or labeling mental conditions or issues as deviant or negative, leading to the detrimental consequences of discrimination, prejudice, exclusion, stereotyping, and status loss (<xref ref-type="bibr" rid="B17">17</xref>).</p>
<p>Potential consequences of stigmatization are a decrease in life satisfaction, lesser likelihood of help seeking behavior, less employment chances, less housing opportunities, fewer social opportunities and received healthcare is of inferior quality (<xref ref-type="bibr" rid="B18">18</xref>&#x2013;<xref ref-type="bibr" rid="B23">23</xref>). Stigmatization does not affect all individuals with mental health problems in the same way. Some respond with indifference towards stigmatizing behavior and others show high levels of psychological resilience, which may even fuel their motivation to challenge negative beliefs (<xref ref-type="bibr" rid="B24">24</xref>). However, the majority of individuals tend to endorse and thereby suffer from stigmatizing attitudes (<xref ref-type="bibr" rid="B25">25</xref>). When someone considers stigmatizing beliefs to be true, these beliefs can be internalized and cause self-stigmatization. Self-stigmatization is the process in which an individual thinks that he or she is socially less acceptable and/or valuable, it involves identification with a stigmatized group, and the internalization of the negative attributes and stereotypes associated with this group (<xref ref-type="bibr" rid="B26">26</xref>). Self-stigmatization is prevalent and is related to demoralization, reduced physical and/or mental health and a diminished self-efficiency, self-esteem and quality of life (<xref ref-type="bibr" rid="B27">27</xref>) (<xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B28">28</xref>) (<xref ref-type="bibr" rid="B29">29</xref>&#x2013;<xref ref-type="bibr" rid="B31">31</xref>).</p>
<p>Several meta-analyses on the effectiveness of interventions to diminish stigmatization (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B32">32</xref>, <xref ref-type="bibr" rid="B33">33</xref>) and self-stigmatization (<xref ref-type="bibr" rid="B24">24</xref>, <xref ref-type="bibr" rid="B31">31</xref>, <xref ref-type="bibr" rid="B34">34</xref>, <xref ref-type="bibr" rid="B35">35</xref>) have been published. These include psycho-education programs, trainings, individual- and group sessions. The results vary substantially; some studies show no effects, while others report high effectiveness in reducing stigma. One of the challenges in providing stigma-reduction trainings is that people often resist acknowledging or recognizing stigmatizing beliefs in themselves because this threatens their self-image. This can cause social desirability and consequently unreliable outcomes on stigma measurements (<xref ref-type="bibr" rid="B36">36</xref>, <xref ref-type="bibr" rid="B37">37</xref>). Recently there has been a shift towards recommending promoting continuum beliefs (e.g. understanding that mental health problems can be seen on a continuum from mild to severe; to some degree all humans suffer from them) rather than explicitly targeting the reduction of stigmatizing attitudes (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B37">37</xref>). Additionally, an ethical question arose while reviewing self-stigma intervention studies: shouldn&#x2019;t the first step be to offer interventions to mental health care workers (MHCWs) before addressing self-stigmatization in patients? This is important because, for many patients, self-stigma often begins within mental health care and is driven by labelling and stigmatization. It seems reasonable to tackle self-stigma by focusing on stigma reduction among mental health care workers (<xref ref-type="bibr" rid="B38">38</xref>). Given that categorical beliefs play a pivotal role in the stigma process, continuum beliefs can be regarded as a countermeasure against stigmatization (<xref ref-type="bibr" rid="B16">16</xref>). We conducted a pilot study to understand the effects of an intervention enhancing continuum beliefs, based on acceptance and commitment therapy (ACT), offered to MHCPs to reduce self-stigmatization in their patients. A continuum concept of mental health and mental illness assumes one dimension from severe psychiatric symptoms to subclinical, light, or non-existent symptoms. Since every person is likely experiencing symptoms of mental illness at some points during their life, a person with severe mental illness might be seen as someone with similar, but with more severe experiences, thus remaining &#x2018;someone like us&#x2019; (<xref ref-type="bibr" rid="B16">16</xref>). In ACT, mental health problems are explained using continuum beliefs, understanding that we all experience emotional difficulties to some extent and in everyone the intensity of the struggle fluctuates over time. Furthermore, ACT enhances psychological flexibility, which is defined as the ability to maintain a gentle and kind awareness of thoughts, emotions, and the present moment, and take action, based on personal values and goals. Psychological inflexibility is found to be positively related to stigmatization (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B40">40</xref>). ACT interventions are promising in the reduction of (self)stigma of mental health problems (<xref ref-type="bibr" rid="B38">38</xref>, <xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B41">41</xref>). The current study focusses on whether self-stigmatization in patients decreases after their MHCP received ACT, with a focus on enhancing continuum beliefs. It is hypothesized that after the intervention for their MCHPs, patients&#x2019; agreement with, beliefs about and application of common mental health stereotypes as well as the &#x2018;hurt-self&#x2019; (self-esteem or self-efficacy as a consequence of internalizing these stereotypes) decreases compared to the control group.</p>
</sec>
<sec id="s2">
<title>Methods</title>
<sec id="s2_1">
<title>Participants and design</title>
<p>A total of 106 MHCPs from the mental health organization Arkin - Mentrum Amsterdam in the Netherlands were randomly selected out of a list of employees (<xref ref-type="fig" rid="f1">
<bold>Figure&#xa0;1</bold>
</xref>: Flowchart MHCPs). MHCPs worked at different departments and teams for treatment of patients with severe mental illness (SMI) at clinics or outreaching teams; e.g. (Functional) Assertive Community Treatment teams. They were invited to participate in the study and informed via email which contained an informed consent form and a demographic questionnaire. The aim was to obtain a diverse sample (social psychiatric nurses, psychiatrists, psychologists, case managers and job coaches all working at teams for treatment of people with severe psychiatric disorders). 42 out of the 106 MHCPs met the inclusion criteria and agreed to participate, one dropped out at the beginning of the study due to work appointments. The inclusion criterion for the MHCP was that during the study they would be able to arrange face to face contact with the participating patient weekly. For MHCP characteristics see <xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>. The number of participants needed for the study was determined by means of G*power analysis for which an alpha level of.05 and a power of.80 were used (<xref ref-type="bibr" rid="B42">42</xref>). Considering the effects from previous research, a medium effect size of.25 was expected, resulting in 28 participants for testing a time*condition interaction (<xref ref-type="bibr" rid="B24">24</xref>, <xref ref-type="bibr" rid="B41">41</xref>).</p>
<fig id="f1" position="float">
<label>Figure&#xa0;1</label>
<caption>
<p>Flowchart MHCPs.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1390949-g001.tif"/>
</fig>
<table-wrap id="T1" position="float">
<label>Table&#xa0;1</label>
<caption>
<p>Demographic characteristics of participants, N = 41.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="top" colspan="6" align="left">Clinicians</th>
</tr>
<tr>
<th valign="top" align="left">Age</th>
<th valign="top" align="left">Gender</th>
<th valign="top" align="left">Education</th>
<th valign="top" align="left">Job</th>
<th valign="top" align="left">Working</th>
<th valign="top" align="left">Encounter</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">40.0<break/>(1.81)</td>
<td valign="top" align="left">32% Men<break/>68% Women</td>
<td valign="top" align="left">2% Senior general secondary education<break/>12% Intermediate vocational education<break/>85% College</td>
<td valign="top" align="left">12% Society worker<break/>39% Psychiatric nurse<break/>7% Community worker<break/>2% Patients confidant<break/>7% Psychologist<break/>15% Job coach<break/>15% Probation officer</td>
<td valign="top" align="left">11.6 years<break/>(1.42 SD)</td>
<td valign="top" align="left">54% Others<break/>5% Self<break/>34% Both<break/>7% None</td>
</tr>
</tbody>
<tbody>
<tr>
<th valign="top" colspan="6" align="left">Patients</th>
</tr>
<tr>
<th valign="top" align="left">Age</th>
<th valign="top" align="left">Gender</th>
<th valign="top" align="left">Education</th>
<th valign="top" align="left">Living situation</th>
<th valign="top" align="left">Years MP</th>
<th valign="top" align="left">Marital status</th>
</tr>
<tr>
<td valign="top" align="left">37.6<break/>(2.19)</td>
<td valign="top" align="left">78% Men<break/>22% Women</td>
<td valign="top" align="left">22% Primary school<break/>17% Lower general secondary education<break/>15% Intermediate vocational education<break/>27% College</td>
<td valign="top" align="left">46% Independent living<break/>2% Student flat<break/>20% With parents<break/>20% Sheltered housing<break/>7% Admitted in mental health hospital<break/>2% Different</td>
<td valign="top" align="left">17.4<break/>(2.57SD)</td>
<td valign="top" align="left">95% Unmarried<break/>5% Divorced</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>Means (SD) of clinicians age, amount of years working in mental health care (Working), percentages of gender, education, job, and having had the encounter of mental health problems in personal life with self and/or others (Encounter). Means (SD) of patients age and the number of years having mental health problems (Years MP), gender, education, living situation and marital status.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<p>The study was approved by the Faculty Ethics Test Board of the University of Utrecht (FETC16-132). The design was an RCT with a pre-test and post-test measurement. Patients received treatment for severe mental illness (SMI) at clinics or outreaching teams; e.g. (Functional) Assertive Community Treatment teams. SMI is defined as a mental, behavioral, or emotional disorder resulting in serious functional impairment, which substantially interferes with or limits one or more major life activities (<xref ref-type="bibr" rid="B43">43</xref>). Most patients received several diagnoses within the spectrum of psychotic disorders, affective disorders, addiction and/or personality disorders accompanied by severe social and societal limitations, mostly persisting for several years. A coupled participant pool was used; every MHCP had to ask one of their patients with whom they were having weekly face-to-face sessions. This was done by telling them to invite the first patient they would meet in the coming week after the contact with the research assistant. 20 MHCPs were randomly assigned to the experimental condition and 21 MHCPs to the control condition, the MHCPs in the control condition were offered the intervention after the study. There were no exclusion criteria for the patients; all were allowed to participate regardless of age, how long they had been receiving treatment (this varied from being in their first week till many years) diagnosis, background, severity of problems or other characteristics (for characteristics of patients see <xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>).</p>
</sec>
<sec id="s2_2">
<title>Intervention</title>
<p>The training offered ACT based tools to work in a &#x2018;destigmatizing&#x2019; way; stimulating disclosure, psychoeducation about continuum beliefs and psychological flexibility around stigmatizing beliefs (<xref ref-type="bibr" rid="B44">44</xref>, <xref ref-type="bibr" rid="B45">45</xref>). The training took half a day (four hours) and combined a theoretical presentation and practical application of ACT to enhance acceptance, cognitive defusion interventions, defining values, connecting to and allowing the present moment and committed action. The theoretical framework of ACT that was used in this training had the aim to understand and create flexibility around stigmatizing &#x2018;us vs them&#x2019; beliefs (&#x2018;I am healthy, you are sick&#x2019; or &#x2018;Mental health problems are not acceptable&#x2019;) and to practice continuum beliefs holding an inclusive and accepting perspective. During the training, the MHCPs were motivated to apply the ACT attitude and theory in the sessions with their patients. The reason for short duration of the training was that MHCP did not have more time in their schedule for in depth education. There are some effective interventions of ACT where short trainings or therapies were offered from 2,5 hours (<xref ref-type="bibr" rid="B46">46</xref>, <xref ref-type="bibr" rid="B47">47</xref>) to 5 hours (<xref ref-type="bibr" rid="B47">47</xref>). The sessions the MHCPs had with their patient before and after the intervention took between 45 minutes to 60 minutes; the exact content of the sessions depended on the nature of the relation between the MHCP and the patient and the kind of sessions/treatment patients received and where they were in their treatment. All MHCPs&#x2019; sessions included at least a discussion of how the patient fared and whether there had been any difficulties or positive events and a reflecting on and/or evaluation of the treatment plan. The time of MHCP and patients knowing each other varied between having their first session together and knowing each other already for many months. The MHCPs in the experimental condition received the four-hour training in groups of ten, given by a licensed healthcare psychologist certified and experienced in ACT; Examples of exercises to practice with their patients after the intervention was offered were: psychoeducation about continuum beliefs of mental health disorders, sharing one&#x2019;s own experiences with emotional difficulties, empathy and compassion enhancing experiential exercises and cognitive interventions on judgmental thoughts. The MHCPs participated in the ACT-training after the first measurement of their patient and had to apply ACT in contact with their patient within two weeks after the training. The post-measurement of the patients was done within one to two weeks after (see also <xref ref-type="fig" rid="f2">
<bold>Figure&#xa0;2</bold>
</xref> for the study process description).</p>
<fig id="f2" position="float">
<label>Figure&#xa0;2</label>
<caption>
<p>Study process description.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1390949-g002.tif"/>
</fig>
</sec>
<sec id="s2_3">
<title>Materials</title>
<p>A validated Dutch version of the Self Stigma of Mental Illness Scale - Short Form [SSMIS-SF (<xref ref-type="bibr" rid="B32">32</xref>)] was used which consists of 20 items scaled on a 9-point Likert scale anchored at 0 (I strongly disagree) to 9 (I strongly agree). The psychometric qualities of the SSMIS-SF are good: the internal consistency lies between a = .72 and a = .91 and the test-retest reliability ranges from.68 to.82. Moreover, the content validity and construct validity are considered good (<xref ref-type="bibr" rid="B32">32</xref>, <xref ref-type="bibr" rid="B48">48</xref>). The questionnaire measures the process of self-stigmatization, consisting of four stages and subsequently subscales, namely <italic>Awareness</italic>, which measures the knowledge of the common stereotypes in society (this sub-scale was adjusted for the current study to measure perceived stigmatization of a patient&#x2019;s MHCP, item example: &#x2018;I think that my MHCP thinks that most persons with mental health problems will not recover or get better&#x2019;); <italic>Agreement</italic>, which measures the agreement with common stereotypes about individuals with mental health problems (item example: &#x2018;I think that most persons with mental health problems are dangerous&#x2019;); <italic>Application</italic>, which measures the internalization of common stereotypes about mental health problems (item example: &#x2018;Because I have mental health problems, I am unpredictable&#x2019;) and <italic>Hurt Self</italic>, which measures self-esteem or self-efficacy as a consequence of internalizing these stereotypes (item example: &#x2018;I currently respect myself less because I am unable to take care of myself&#x2019;). The SSMIS-SF consists of four valid and reliable sub-scales measuring different aspects of (self)-stigmatization; the total score should not be used as an aggregated measure. Therefore, scales have to be interpreted separately. The subscales have been found to be reliable with Cronbach&#x2019;s alpha coefficients of .72 for Agreement, .81 for Application, .88 for Hurts Self, and .91 for Awareness (<xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B49">49</xref>). Also, a demographic questionnaire for patients and a demographic questionnaire for MHCPs, including an item regarding personal experience with mental health problems was used.</p>
</sec>
<sec id="s2_4">
<title>Statistical analysis</title>
<p>The data were analyzed using a 2 (pre-test/post-test) x 2 (no training/training) repeated measures design multivariate analysis of variance (MANOVA). An alpha of .05 was used and two-tailed tests were reported. In order to measure the effectiveness of the training, scores of patients in the control group versus scores of patients in the experimental condition were measured by means of interaction effect of time and condition.</p>
</sec>
</sec>
<sec id="s3" sec-type="results">
<title>Results</title>
<p>No significant differences were found between characteristics of patients and MHCPs in both conditions (the age of MHCPs, the amount of years working in mental health care, the age of patients, the amount of years of patients having mental health problems, gender, having mental health problems in loved ones or personal mental health problems in MHCPs, the function of MHCPs, gender of patients, marital status of patients, and living situation of patients).</p>
<p>No significant differences between conditions on the SSMIS-SF were found, t(39) = -0.43, p = .67, indicating that pre-test self-stigmatization scores were not different over conditions (see <xref ref-type="table" rid="T2">
<bold>Table&#xa0;2</bold>
</xref> for descriptive statistics).</p>
<table-wrap id="T2" position="float">
<label>Table&#xa0;2</label>
<caption>
<p>Descriptive Statistics for SSMIS-SF Scores.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="bottom" align="center">Scale</th>
<th valign="bottom" align="center">Pretest M (SD)</th>
<th valign="bottom" align="center">Pretest N</th>
<th valign="bottom" align="center">Pretest Min</th>
<th valign="bottom" align="center">Pretest Max</th>
<th valign="bottom" align="center">Posttest M (SD)</th>
<th valign="bottom" align="center">Posttest N</th>
<th valign="bottom" align="center">Posttest Min</th>
<th valign="bottom" align="center">Posttest Max</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">Agree</td>
<td valign="bottom" align="left">18.43 (8.57)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">45</td>
<td valign="bottom" align="left">17.43 (7.78)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">37</td>
</tr>
<tr>
<td valign="bottom" align="left">Apply</td>
<td valign="bottom" align="left">13.48 (6.74)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">28</td>
<td valign="bottom" align="left">12.10 (5.55)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">25</td>
</tr>
<tr>
<td valign="bottom" align="left">Aware</td>
<td valign="bottom" align="left">19.52 (11.92)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">42</td>
<td valign="bottom" align="left">17.86 (10.10)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">38</td>
</tr>
<tr>
<td valign="bottom" align="left">Hurts Self</td>
<td valign="bottom" align="left">10.86 (6.24)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">32</td>
<td valign="bottom" align="left">11.43 (6.84)</td>
<td valign="bottom" align="left">21</td>
<td valign="bottom" align="left">5</td>
<td valign="bottom" align="left">29</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>Considering Application, no significant differences between conditions on pre-test scores were found, t(39) = -1.71, p = .10, indicating that pre-test Application scores were not different over conditions. No significant differences between conditions on Agreement, t(39) = 0.74, p = .46, Awareness, t(1, 33.52) = 1.29, p = .21, and Hurt-self, t(1, 33.11) = -1.98, p = .06, were found, indicating that pre-test scores were not different over conditions.</p>
<p>No effect of time was found on the subscale Awareness, <italic>F</italic>(1,39) = .04, p = .85 and no effect of condition was found for Awareness, F(1,39) = .85, p = .36, also no significant interaction effects were found <italic>F</italic>(1,39) = 2.02, p = .16 suggesting that the ACT-training had no effect on the &#x2018;Awareness&#x2019; subscale, compared to the control condition.</p>
<p>For the subscale Agreement, a significant effect of time was found (<xref ref-type="fig" rid="f3">
<bold>Figure&#xa0;3</bold>
</xref>), <italic>F</italic>(1,39) = 9.86, p &lt;.01 &#x3b7;<sub>p</sub>
<sup>2</sup> = .87, meaning that over time Agreement scores decreased in both conditions. No significant effect of condition was found for Agreement, <italic>F</italic>(1,39) = .00, p = .98, and no significant interaction effect was found, <italic>F</italic>(1,39) = 1.31, p =.26. suggesting that the ACT-training had no effect on the &#x2018;Agreement &#x2018; subscale, compared to the control condition.</p>
<fig id="f3" position="float">
<label>Figure&#xa0;3</label>
<caption>
<p>Pre- and post-test means (SD) of Agreement-scores per condition.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1390949-g003.tif"/>
</fig>
<p>For the subscale &#x2018;Application&#x2019;, the analysis demonstrated no significant effect of time, <italic>F</italic> (1,39) = .11, p = .74 or condition, <italic>F</italic>(1,39) = .19, p = .67. However, a significant interaction effect of time and condition was found, <italic>F</italic> (1,39) = 9.33, p &lt; 0.01, &#x3b7;<sub>p</sub>
<sup>2</sup> = .85 (<xref ref-type="fig" rid="f4">
<bold>Figure&#xa0;4</bold>
</xref>). This finding suggests that the ACT-training had a significant favorable effect on the &#x2018;Application&#x2019; subscale, compared to the control condition with an effect size of .193 (<xref ref-type="bibr" rid="B50">50</xref>, <xref ref-type="bibr" rid="B51">51</xref>). The increase in &#x2018;Application&#x2019; scores in the control condition was approximately as large as the decrease in the experimental condition (<xref ref-type="fig" rid="f5">
<bold>Figure&#xa0;5</bold>
</xref>).</p>
<fig id="f4" position="float">
<label>Figure&#xa0;4</label>
<caption>
<p>Pre- and post-test means (SD) of Application-scores per condition.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1390949-g004.tif"/>
</fig>
<fig id="f5" position="float">
<label>Figure&#xa0;5</label>
<caption>
<p>Pre- and post-test means of Hurt-self scores per condition.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fpsyt-15-1390949-g005.tif"/>
</fig>
<p>Hurt-self: On the subscale no effect of time <italic>F</italic>(1,39) = 1.90, p = .18. or condition <italic>F</italic>(1,39) = 1.66, p = .21. was found. Furthermore, a non-significant trend interaction effect was found <italic>F</italic>(1,39) = 3.78, p = .056. suggesting a potential favorable effect in the intervention condition.</p>
</sec>
<sec id="s4" sec-type="discussion">
<title>Discussion</title>
<p>The focus of this study was to target self-stigmatization as it is known to be prevalent and detrimental for many patients in mental healthcare. To the best of our knowledge, the present study has been the first study to examine the impact of training MHCPs in ACT on reducing self-stigmatization among their patients. A significant effect of the intervention on the subscale Application was found; indicating a positive effect on reducing the internalization of mental health stereotypes among patients. Interestingly, scores on the Application subscale increased over time in the control condition. The hypothesis was not supported for the other subscales: Awareness, Agreement and Hurt-self (although favorable effect concerning Hurt-self were observed at a trend level). These findings suggest that the intervention did not result in significant changes in awareness of, agreement with, commonly held stereotypes, or self-esteem.</p>
<p>Self-stigmatization is commonly conceptualized as a process, encompassing identification with a stigmatized group and the internalization of negative attributes and stereotypes associated with that group (<xref ref-type="bibr" rid="B17">17</xref>). The subscales utilized in this study assess different stages of the self-stigmatization process and the subscales can only be interpreted separately. Awareness: this stage involves individuals becoming conscious of the existing stereotypes about mental illnesses, such as beliefs held by the public or mental healthcare professionals that attribute blame to individuals with mental illnesses for their problems (e.g., &#x201c;The public/MHCP believes most people with mental illnesses are to blame for their problems.&#x201d;). Agreement: After becoming aware of these stereotypes, individuals may then internalize and agree with them, reflecting their personal endorsement of such beliefs (e.g., &#x201c;I think most people with mental illness are to blame for their problems.&#x201d;). The first two stages of the process are not &#x2018;personal&#x2019; yet; one can be aware of or agree with the statements without experiencing self-stigmatization. Application: At this stage, individuals apply the stereotypes onto themselves, attributing the negative stereotypes to their own experience with mental illness (e.g., &#x201c;Because I have a mental illness, I am to blame for my problems.&#x201d;). Hurt-self: As a consequence of the preceding stages, individuals may experience negative impacts on their self-esteem and self-worth, perceiving a loss of respect for themselves due to the belief that they are responsible for their problems (e.g., &#x201c;I currently respect myself less because I am to blame for my problems.&#x201d;). One implication of this model is that the &#x2018;harmful&#x2019; effects of self-stigmatization do not occur until the later stages (Application and Hurt-self) when the person has internalized the stigma (<xref ref-type="bibr" rid="B32">32</xref>).</p>
<p>The subscale &#x201c;Application&#x201d; measures the internalization of negative stereotypes about mental health problems: from all the subscales this definition is most in line with the most commonly used definition of self-stigma (<xref ref-type="bibr" rid="B52">52</xref>) and was the only subscale that changed significantly. We propose that there was no significant effect found on the recognition of or the agreement with stereotypes alone (as measured by the Awareness and Agreement subscales) because these subscales measure beliefs that have been formed over a lifetime of socialization and were not affected by the ACT intervention. ACT does not attempt to decrease awareness or to change beliefs but to have more awareness of how these beliefs work and of how to create cognitive flexibility around them (for example to make people aware of the possibility not to apply the stereotypical beliefs they have onto themselves). So perhaps ACT doesn&#x2019;t quickly modify the presence of self-stigmatizing psychological content, but alters its impact or function (e.g. believability). Varra et&#xa0;al. showed that ACT reduced the believability of barriers and greater psychological flexibility mediated the impact of the intervention in clinicians (<xref ref-type="bibr" rid="B53">53</xref>). Their results support the idea that acceptance-based interventions may be helpful in addressing the psychological factors related to poor adoption of evidence-based treatments. Unlike our study Hayes et&#xa0;al. observed that ACT also significantly changed the believability of stigmatizing attitudes (<xref ref-type="bibr" rid="B54">54</xref>).</p>
<p>Interestingly, the increase in Application scores in the control condition was approximately as large as the decrease in the experimental condition. A theory that could explain the observed increase of Application scores in the control condition can be found in the Ironic Process Theory. This theory states that negative (self)beliefs are partly suppressed into the subconscious (<xref ref-type="bibr" rid="B55">55</xref>). Addressing beliefs for instance through measurement with stereotypical statements has the potential to increase individuals&#x2019; awareness of them and hence can result in higher scores over time (<xref ref-type="bibr" rid="B56">56</xref>). An explanation for why this effect did not appear in the other subscales (Awareness and Agreement) is that the latter two scales measure &#x2018;general&#x2019; beliefs, the subscale &#x201c;Agreement&#x201d; aims to measure the agreement with commonly held stereotypes about individuals with mental health problems and the subscale of Awareness measures the knowledge of common mental health stereotypes in society. Possibly these scores are not affected by the Ironic Process Theory because general beliefs are less likely to be suppressed (<xref ref-type="bibr" rid="B52">52</xref>).</p>
<p>On the subscale &#x2018;Agreement&#x2019; patients in both conditions scored lower over time meaning that, because treatment as usual which both conditions received or because of other factors, they agreed less with the stereotypical beliefs as stated in the ISMI-SF. Interestingly, despite a decrease in &#x2018;Agreement&#x2019; with the commonly held stereotypes observed in the control condition, there was still an increase in the application of these stereotypes onto oneself. This indicates that even though patients agreed less with stereotypes over time they still continued to apply them to themselves and internalized them. It could be that somehow the explicit beliefs (conscious beliefs) changed but the implicit (subconscious) beliefs did not which caused the application of the beliefs onto oneself to remain.</p>
<p>Furthermore, it is noteworthy that the intervention did not result in significant changes in the Hurt-self subscale. This subscale holds significance within the stigmatization process, as it has been found to be correlated with self-esteem, self-efficacy, empowerment, and hope (<xref ref-type="bibr" rid="B29">29</xref>). It is possible that these deeply rooted self-esteem beliefs are less amenable to change within the scope of a single workshop and session with mental healthcare professionals. Additional interventions or prolonged engagement may be required to stimulate change in this particular area.</p>
<sec id="s4_1">
<title>Limitations and strengths</title>
<p>Several limitations and strengths of this study should be mentioned. Firstly, a larger sample size of participating MHCPs and patients would have provided a better opportunity to observe significant changes in more domains of self-stigmatization and gain a more comprehensive understanding of the intervention&#x2019;s effectiveness. Secondly; the MHCP was aware which one of their patients was included in the study, which may have implications for how the MHCP interacted with the patient: to prevent the potential bias in future studies it might be better to keep the MHCP blind for which of their patients is included. Thirdly no follow-up data were gathered to observe the effects over time and no active intervention was offered in the control condition, thereby making it difficult to conclude whether non-specific factors are responsible for the effects.</p>
<p>We consider it a strength of this study that we introduced and tested a new approach in addressing self-stigmatization by shifting the &#x201c;responsibility&#x201d; of diminishing (self-)-stigmatization from the patient to the MHCP. Moreover, the effect on the application subscale found in the analyses supports the added value of future research on the potential of this alternative approach to reduce self-stigmatization. Future research could benefit from first developing specific interventions focusing on the different elements in the process of self-stigmatization. Given the current findings with a relatively non intensive intervention, we consider further research on this alternative approach valuable. We recommend considering the following aspects in future research: to measure potential effects in several patients of each MHCP, to offer a longer intensive training intervention in the experimental condition to enhance the effect of the intervention, additional training/follow-up booster ACT and to include a larger sample.</p>
</sec>
</sec>
</body>
<back>
<sec id="s5" sec-type="data-availability">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="s6" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>The studies involving humans were approved by Faculty Ethics Test Board of the University of Utrecht (FETC16-132). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec id="s7" sec-type="author-contributions">
<title>Author contributions</title>
<p>KH: Writing &#x2013; original draft, Writing &#x2013; review &amp; editing. MDo: Writing &#x2013; original draft, Writing &#x2013; review &amp; editing. MDe: Writing &#x2013; review &amp; editing. IM-G: Writing &#x2013; review &amp; editing. FS: Writing &#x2013; review &amp; editing. TV: Writing &#x2013; review &amp; editing. DN: Writing &#x2013; review &amp; editing. MJ: Supervision, Writing &#x2013; review &amp; editing. AP: Supervision, Writing &#x2013; review &amp; editing. LH: Writing &#x2013; review &amp; editing.</p>
</sec>
<sec id="s8" sec-type="funding-information">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<sec id="s9" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s10" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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