<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="2.3" xml:lang="EN">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2023.1204544</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>The relationship between fall and loneliness among older people in China: the mediating role of personality trait</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Yuan</surname>
<given-names>Luo</given-names>
</name>
<xref rid="aff1" ref-type="aff"><sup>1</sup></xref>
<xref rid="fn0010" ref-type="author-notes"><sup>&#x2020;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2064994/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yibo</surname>
<given-names>Wu</given-names>
</name>
<xref rid="aff2" ref-type="aff"><sup>2</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1057477/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yuqian</surname>
<given-names>Deng</given-names>
</name>
<xref rid="aff3" ref-type="aff"><sup>3</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2099817/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Haiye</surname>
<given-names>Ran</given-names>
</name>
<xref rid="aff3" ref-type="aff"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jiaxin</surname>
<given-names>Liu</given-names>
</name>
<xref rid="aff3" ref-type="aff"><sup>3</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/2099464/overview"/>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Liping</surname>
<given-names>Zhao</given-names>
</name>
<xref rid="aff4" ref-type="aff"><sup>4</sup></xref>
<xref rid="c001" ref-type="corresp"><sup>&#x002A;</sup></xref>
<xref rid="fn0011" ref-type="author-notes"><sup>&#x2020;</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/981554/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>School of Nursing, Capital Medical University</institution>, <addr-line>Beijing</addr-line>, <country>China</country></aff>
<aff id="aff2"><sup>2</sup><institution>School of Public Health, Peking University</institution>, <addr-line>Beijing</addr-line>, <country>China</country></aff>
<aff id="aff3"><sup>3</sup><institution>Xiang Ya Nursing School, Central South University</institution>, <addr-line>Changsha, Hunan Province</addr-line>, <country>China</country></aff>
<aff id="aff4"><sup>4</sup><institution>Xiang Ya Second Hospital of Central South University</institution>, <addr-line>Changsha, Hunan Province</addr-line>, <country>China</country></aff>
<author-notes>
<fn fn-type="edited-by" id="fn0002"><p>Edited by: Yuka Kotozaki, Iwate Medical University, Japan</p></fn>
<fn fn-type="edited-by" id="fn0003"><p>Reviewed by: Gema P&#x00E9;rez-Rojo, CEU San Pablo University, Spain; Carlo Lazzari, South West Yorkshire Partnership NHS Foundation Trust, United Kingdom</p></fn>
<corresp id="c001">&#x002A;Correspondence: Zhao Liping, <email>zhaolp0818@csu.edu.cn</email></corresp>
<fn id="fn0010" fn-type="equal"><p><sup>&#x2020;</sup>ORCID: Luo Yuan <ext-link ext-link-type="uri" xlink:href="http://orcid.org/0000-0003-1198-3877">orcid.org/0000-0003-1198-3877</ext-link></p></fn>
<fn id="fn0011" fn-type="equal"><p><sup>&#x2020;</sup>Zhao Liping <ext-link ext-link-type="uri" xlink:href="http://orcid.org/0000-0002-7682-9339">orcid.org/0000-0002-7682-9339</ext-link></p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>08</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>14</volume>
<elocation-id>1204544</elocation-id>
<history>
<date date-type="received">
<day>12</day>
<month>04</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>07</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2023 Yuan, Yibo, Yuqian, Haiye, Jiaxin and Liping.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Yuan, Yibo, Yuqian, Haiye, Jiaxin and Liping</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Aims</title>
<p>We aimed to explore the role of personality traits between fall and loneliness.</p>
</sec>
<sec id="sec2">
<title>Methods</title>
<p>A questionnaire survey was used to investigate falls, the big five personality traits, and loneliness among older people (&#x2265;&#x2009;60&#x2009;years old) in China mainland.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>A total of 4,289 older people participated in the survey. There are significant differences in age, marital status, education level, residence, solitariness, and fall in relation to loneliness among older people. Falls, especially when they occurred one time increase the loneliness of older people. Agreeableness, conscientiousness, and neuroticism were significant mediating effects between falls and loneliness.</p>
</sec>
<sec id="sec4">
<title>Conclusion</title>
<p>This study implied that agreeableness, conscientiousness, and neuroticism were meditating factors between falls and loneliness. In the future, we should consider the big five personality traits more to understand loneliness and offer older people interventions for reducing their loneliness. The study design was cross-sectional, so the temporal precedence of mediators and causality could not be tested. Because the data were collected retrospectively, current loneliness is likely to have confounding effects on retrospective recall.</p>
</sec>
</abstract>
<kwd-group>
<kwd>loneliness</kwd>
<kwd>social isolation</kwd>
<kwd>accidental fall</kwd>
<kwd>older people</kwd>
<kwd>big five personality</kwd>
<kwd>mediating effect</kwd>
</kwd-group>
<contract-num rid="cn1">2021JJ70068</contract-num>
<contract-sponsor id="cn1">Hunan Natural Science Foundation</contract-sponsor>
<counts>
<fig-count count="0"/>
<table-count count="3"/>
<equation-count count="0"/>
<ref-count count="53"/>
<page-count count="8"/>
<word-count count="6017"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Public Mental Health</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<label>1.</label>
<title>Introduction</title>
<p>In general, loneliness is the discrepancy between a person&#x2019;s preferred and actual level of social contact. Loneliness reflects a subjective feeling of the absence of desired affection and closeness from close family members, intimate friends, or someone significant (<xref ref-type="bibr" rid="ref1">1</xref>). With the accelerating aging and increasing life expectancy in China, loneliness is growing among older people, especially older people with poor health (<xref ref-type="bibr" rid="ref2">2</xref>). In China, for example, a national survey found that 29.6% of older people (&#x2265;&#x2009;60&#x2009;years old) reported that they &#x2018;often felt lonely&#x2019; (<xref ref-type="bibr" rid="ref3">3</xref>). During the pandemic, especially, 34.2% of older people suffered from loneliness, of which 15.5% were severely lonely (<xref ref-type="bibr" rid="ref4">4</xref>). Many studies showed that loneliness is highly related to the health status of older people. In a large sample survey, loneliness strongly indicated the development of pain, fatigue, and depression as well as the cluster of all three symptoms several years later (<xref ref-type="bibr" rid="ref5">5</xref>). For mental health, loneliness was longitudinally associated with posttraumatic stress symptoms, and there might be a bidirectional predictive relationship (<xref ref-type="bibr" rid="ref6">6</xref>, <xref ref-type="bibr" rid="ref7">7</xref>).</p>
<p>In China, as the aging process accelerates, fall is still a serious problem. It was reported that the annual fall rate among Chinese older people ranged from 11 to 34% (<xref ref-type="bibr" rid="ref8">8</xref>); 54.95 per 1,000 injuries would be fall-related injuries (<xref ref-type="bibr" rid="ref9">9</xref>), and unintentional falls mortality rose from 7.65 to 8.03 per 100,000 people between 2006 and 2016 (<xref ref-type="bibr" rid="ref10">10</xref>). According to a survey, older people who have experienced a fall would reduce social participation actively (<xref ref-type="bibr" rid="ref11">11</xref>). After older people experienced a fall, they would make activity restrictions and gradually make subsequent social isolation (<xref ref-type="bibr" rid="ref12">12</xref>). This could further increase feelings of loneliness. Fall was associated with loneliness among older people, which was common for those living alone (<xref ref-type="bibr" rid="ref13">13</xref>, <xref ref-type="bibr" rid="ref14">14</xref>). A longitudinal study showed that both low social contact and living alone among older people were highly associated with self-reported falls even after controlling for sociodemographic, health, and lifestyle variables (<xref ref-type="bibr" rid="ref15">15</xref>). According to the German Aging Survey, any fall in the past 12&#x2009;months was associated with increased odds of loneliness among older adults. A higher level of loneliness showed in more times fall occurred (<xref ref-type="bibr" rid="ref16">16</xref>). A systematic review implied the association between falls and loneliness among older people (<xref ref-type="bibr" rid="ref17">17</xref>). Therefore, we need to explore the relationship between fall and loneliness further.</p>
<p>Since the 1990s, the Big Five personality has been a hot research topic, which consists of extraversion, agreeableness, conscientiousness, neuroticism, and openness (<xref ref-type="bibr" rid="ref18">18</xref>, <xref ref-type="bibr" rid="ref19">19</xref>). While the Big Five personality may be regarded as an important model in personality studies, it is not an integrative model (<xref ref-type="bibr" rid="ref19">19</xref>). Each personality trait has a unique impact on psychology and behavior. A systematic review showed that different personality traits had different attitudes to falls among older people (<xref ref-type="bibr" rid="ref20">20</xref>). That was important for the successful implementation of fall-prevention programs. A study indicated that the relationship between loneliness and personality was largely explained by its relationship with neuroticism (<xref ref-type="bibr" rid="ref21">21</xref>). Neuroticism was positively associated with indoor falls and recurrent outdoor falls (<xref ref-type="bibr" rid="ref22">22</xref>). Moreover, it was proved that agreeableness among older people was negatively associated with loneliness (<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref24">24</xref>). Fallen older people feel so lonely that they reduce social contact. If they are unwilling to seek help due to their personality traits, they will experience more loneliness as a result (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref12">12</xref>, <xref ref-type="bibr" rid="ref25">25</xref>). Therefore, it is important that the Big Five personality traits be studied to assist in understanding loneliness and offer the interventions for reducing loneliness among older people.</p>
<p>In summary, fallen older people are more likely to feel lonely. At present, although the relationships among the variables of fall, loneliness, and personality trait have been examined separately, there is a lack of studies to explore the relationship between the three. Hence, this study aims to explore the mediating role of personality traits between falls and loneliness among older people in China.</p>
</sec>
<sec sec-type="methods" id="sec6">
<label>2.</label>
<title>Methods</title>
<sec id="sec7">
<label>2.1.</label>
<title>Participants and procedures</title>
<p>A multi-stage sampling method was selected from 20 June to 31 August in the &#x201C;Psychology and Behavior Investigation of Chinese Residents in 2022, PBICR.&#x201D; In this cross-sectional survey study, the participants were from 23 provinces, 5 autonomous regions, and 4 municipalities directly under the central government in China. Training investigators distributed the questionnaires to participants face-to-face and one-on-one (<xref ref-type="bibr" rid="ref26">26</xref>). This study has been officially registered in the China Clinical Trial Registry (Registration No. ChiCTR2200061046). A total of 31,480 questionnaires were distributed. The inclusion criteria:(1) The participants had the nationality of the People&#x2019;s Republic of China; (2) they voluntarily participated in the study and signed an informed consent form; and (3) they understood each item of the questionnaire and completed the questionnaire on their own or with the help of an investigator. The exclusion criteria: (1) The participants were confused, mentally abnormal, or have cognitive impairment; (2) they were currently participating in other similar studies. The excluding invalid questionnaires: (1) filling time&#x2009;&#x2264;&#x2009;100&#x2009;s; (2) conflicting answers between entries; and (3) incompletely filled. Finally, 30,505 valid questionnaires were collected, with an effective rate of 96.9%.</p>
<p>In our study, older people were selected. The age of participants must be equal to or more than 60&#x2009;years old. Finally, 4,289 older people were enrolled in this study.</p>
</sec>
<sec id="sec8">
<label>2.2.</label>
<title>Measures</title>
<sec id="sec9">
<label>2.2.1.</label>
<title>Sociodemographic characteristics</title>
<p>The questionnaire also contained questions related to participants&#x2019; sociodemographic characteristics, including age, gender, marital status, education level, monthly family income, residence, and solitariness.</p>
</sec>
<sec id="sec10">
<label>2.2.2.</label>
<title>Fall</title>
<p>Falls are defined as sudden, uncontrollable changes in body posture that result in an individual falling to the ground or low flat surfaces, which can result in serious injuries, unconsciousness, or seizures (<xref ref-type="bibr" rid="ref9">9</xref>). In this study, falls are divided into three categories: (1) No fall; (2) A single fall means that the fall frequency is once; and (3) Multiple falls mean that fall frequency is more than once. The survey explored the number of falls in the last 3&#x2009;months.</p>
</sec>
<sec id="sec11">
<label>2.2.3.</label>
<title>Personality</title>
<p>The Ten-Item Big Five Personality Inventory (BFI-10) (<xref ref-type="bibr" rid="ref27">27</xref>, <xref ref-type="bibr" rid="ref28">28</xref>) was selected to investigate personality. It is a very short measure of the Big Five personality traits (extraversion, agreeableness, conscientiousness, neuroticism, and openness). Each personality dimension is measured by two items. The scale is adopted on a 5-point Likert scale ranging from one (disagree strongly) to five (agree strongly). Items 1, 3, 4, 5, and 7 are reverse scoring, and items 2, 6, 8, 9, and 10 are forward scoring. Higher scores indicate higher levels of a given personality trait. The Cronbach&#x2019;s &#x03B1; of the BFI-10 in our study was 0.600.</p>
</sec>
<sec id="sec12">
<label>2.2.4.</label>
<title>Loneliness</title>
<p>Loneliness was measured using the Three-Item Loneliness Scale (T-ILS) (<xref ref-type="bibr" rid="ref29">29</xref>). The items for the T-ILS were &#x201C;How often do you feel left out?,&#x201D; &#x201C;How often do you feel isolated from others?,&#x201D; and &#x201C;How often do you feel that you lack companionship?&#x201D; The scale is adopted on a 3-point Likert scale (1&#x2009;=&#x2009;hardly ever, 2&#x2009;=&#x2009;some of the time, and 3&#x2009;=&#x2009;often). The score range of the T-ILS is thus three to nine. Loneliness becomes more apparent as the score rises. The T-ILS was originally derived from the UCLA Loneliness Scale, which was used for older people (<xref ref-type="bibr" rid="ref30">30</xref>). In many studies, the T-ILS is increasingly being used for older people (<xref ref-type="bibr" rid="ref31">31</xref>, <xref ref-type="bibr" rid="ref32">32</xref>). The Cronbach&#x2019;s <italic>&#x03B1;</italic> of the T-ILS in our study was 0.849.</p>
</sec>
</sec>
<sec id="sec13">
<label>2.3.</label>
<title>Statistical analysis</title>
<p>SPSS 26.0 was used to make statistical analysis. Descriptive statistics of sociodemographic characteristics and variables of interest were reported. Frequency and percentage were used to describe categorical variables. Continuous variables were reported on the mean (<italic>M</italic>) and standard deviation (SD). One-way ANOVA test and independent t-test were used to examine the differences in loneliness. <italic>p</italic> &#x003C; 0.05 was considered statistically significant. Further, we used the <italic>post hoc</italic> test for significant difference factors by the statistics method of LSD. Spearman analyses were performed to examine whether there is a correlation between the big five personality traits and falls. Pearson correlation analyses were performed to examine whether there is a correlation between the big five personality and loneliness. Multiple linear regression analysis was conducted to further explore the associated factors which had statistical significance in univariate analysis.</p>
<p>The macro-program PROCESS 3.4 was selected to examine the mediation of the big five personality traits between fall and loneliness (<xref ref-type="bibr" rid="ref33">33</xref>, <xref ref-type="bibr" rid="ref34">34</xref>). Model 4 was used to test the direct, indirect, and total effects based on 5,000 bootstrapped samples. The mediating effect was significant if the 95% bias-corrected confidence interval did not include zero.</p>
</sec>
</sec>
<sec sec-type="results" id="sec14">
<label>3.</label>
<title>Results</title>
<sec id="sec15">
<label>3.1.</label>
<title>Common method biases tests</title>
<p>For this study, subjectivity was excluded as much as possible in order to avoid common method bias. The samples were collected nationwide and anonymously. In the meantime, the exploratory factor analysis method was used to test the common method bias. The results revealed three factors with an eigenvalue greater than one, and the total variation explained by the first factor was 22.303%, which was far lower than the critical value of 40%. Thus, there was no significant common method bias.</p>
</sec>
<sec id="sec16">
<label>3.2.</label>
<title>Descriptive statistics</title>
<p>A total of 4,289 older people participated in the survey. The mean age was (<italic>68.82&#x2009;&#x00B1;&#x2009;6.315</italic>) years old, of which 85.6% were younger than 75. The proportion of men (<italic>49.1%</italic>) and women (<italic>50.9%</italic>) is balanced. Overall, the incidence of falls among older people within 3&#x2009;months was 9.47%. The incidence of falls under 75&#x2009;years old was 9.23%, and the incidence of falls above 75&#x2009;years old was 10.88%. Plus, the incidence of falls in older men was 9.03%, and in older women was 9.89%. Within 3&#x2009;months, the rate of multiple falls was 2.80% among older people. Among those younger than 75&#x2009;years old, the rate of multiple falls was 31.86, and 17.91% occurred among those older than 75&#x2009;years old. Among men, the rate of multiple falls was 2.99%, accounting for 33.16% of total falls. For women, the rate of multiple falls was 2.61%, accounting for 26.39% of total falls. Moreover, the big five personality (extraversion, agreeableness, conscientiousness, neuroticism, and openness) scores were (<italic>6.48&#x2009;&#x00B1;&#x2009;1.505</italic>), (<italic>7.00&#x2009;&#x00B1;&#x2009;1.409</italic>), (<italic>7.13&#x2009;&#x00B1;&#x2009;1.525</italic>), (<italic>5.90&#x2009;&#x00B1;&#x2009;1.354</italic>), and (<italic>6.31&#x2009;&#x00B1;&#x2009;1.426</italic>).</p>
<p><xref rid="tab1" ref-type="table">Table 1</xref> shows participants&#x2019; characteristics and the corresponding distributions of the loneliness scores. Overall, the total loneliness score was (<italic>4.45&#x2009;&#x00B1;&#x2009;1.547</italic>). According to the results, there was a significant difference in age, marital status, education level, residence, solitariness, and fall. According to the <italic>post hoc</italic> test, the loneliness scores of the married were lower than the unmarried, the divorced, and the widowed (<italic>p &#x003C; 0.001</italic>). The loneliness scores of older people with multiple falls were higher than those with a single fall (<italic>p &#x003C; 0.001</italic>) and with no fall (<italic>p &#x003C; 0.001</italic>).</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Loneliness scores among older people with different characteristics (<italic>n</italic>&#x2009;=&#x2009;4,289).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" valign="top">Number (%)</th>
<th align="center" valign="top">Loneliness</th>
<th align="center" valign="top"><italic>t/F</italic> value</th>
<th align="center" valign="top">Value of <italic>p</italic></th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Age (years)</italic></td>
<td align="center" valign="top"><italic>&#x2212;3.058</italic></td>
<td align="center" valign="top"><italic>0.002</italic></td>
</tr>
<tr>
<td align="left" valign="middle">&#x2264;&#x2009;75</td>
<td align="center" valign="middle">3,673 (85.6)</td>
<td align="center" valign="middle">4.42&#x2009;&#x00B1;&#x2009;1.523</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">&#x003E; 75</td>
<td align="center" valign="middle">616 (14.4)</td>
<td align="center" valign="middle">4.63&#x2009;&#x00B1;&#x2009;1.671</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Gender</italic></td>
<td align="center" valign="top"><italic>&#x2212;1.514</italic></td>
<td align="center" valign="top"><italic>0.130</italic></td>
</tr>
<tr>
<td align="left" valign="middle">Men</td>
<td align="center" valign="middle">2,105 (49.1)</td>
<td align="center" valign="middle">4.42&#x2009;&#x00B1;&#x2009;1.527</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Women</td>
<td align="center" valign="middle">2,184 (50.9)</td>
<td align="center" valign="middle">4.49&#x2009;&#x00B1;&#x2009;1.565</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Marital status</italic></td>
<td align="center" valign="top"><italic>27.433</italic></td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="middle">Unmarried</td>
<td align="center" valign="middle">122 (2.8)</td>
<td align="center" valign="middle">4.98&#x2009;&#x00B1;&#x2009;1.674</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Married</td>
<td align="center" valign="middle">3,576 (83.4)</td>
<td align="center" valign="middle">4.36&#x2009;&#x00B1;&#x2009;1.496</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Divorced</td>
<td align="center" valign="middle">103 (2.4)</td>
<td align="center" valign="middle">4.91&#x2009;&#x00B1;&#x2009;1.652</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Widowed</td>
<td align="center" valign="middle">488 (11.4)</td>
<td align="center" valign="middle">4.92&#x2009;&#x00B1;&#x2009;1.722</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Education level</italic></td>
<td align="center" valign="top"><italic>3.309</italic></td>
<td align="center" valign="top"><italic>0.002</italic></td>
</tr>
<tr>
<td align="left" valign="middle">Primary and below</td>
<td align="center" valign="middle">2047 (47.7)</td>
<td align="center" valign="middle">4.53&#x2009;&#x00B1;&#x2009;1.529</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Above primary</td>
<td align="center" valign="middle">2,242 (52.3)</td>
<td align="center" valign="middle">4.38&#x2009;&#x00B1;&#x2009;1.559</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Monthly family income (&#x00A5;)</italic></td>
<td align="center" valign="top"><italic>0.543</italic></td>
<td align="center" valign="top"><italic>0.653</italic></td>
</tr>
<tr>
<td align="left" valign="middle">&#x2264;3,000</td>
<td align="center" valign="middle">1881 (43.8)</td>
<td align="center" valign="middle">4.44&#x2009;&#x00B1;&#x2009;1.559</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">3,001&#x2009;~&#x2009;6,000</td>
<td align="center" valign="middle">1760 (41.1)</td>
<td align="center" valign="middle">4.45&#x2009;&#x00B1;&#x2009;1.520</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">6,001&#x2009;~&#x2009;9,000</td>
<td align="center" valign="middle">375 (8.7)</td>
<td align="center" valign="middle">4.55&#x2009;&#x00B1;&#x2009;1.498</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">&#x2265;9,001</td>
<td align="center" valign="middle">273 (6.4)</td>
<td align="center" valign="middle">4.44&#x2009;&#x00B1;&#x2009;1.695</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Residence</italic></td>
<td align="center" valign="top"><italic>4.646</italic></td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="middle">Rural</td>
<td align="center" valign="middle">1919 (44.7)</td>
<td align="center" valign="middle">4.57&#x2009;&#x00B1;&#x2009;1.549</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Urban</td>
<td align="center" valign="middle">2,370 (55.3)</td>
<td align="center" valign="middle">4.35&#x2009;&#x00B1;&#x2009;1.538</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Solitary</italic></td>
<td align="center" valign="top"><italic>&#x2212;9.712</italic></td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="middle">No</td>
<td align="center" valign="middle">3,658 (85.3)</td>
<td align="center" valign="middle">4.36&#x2009;&#x00B1;&#x2009;1.487</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Yes</td>
<td align="center" valign="middle">631 (14.7)</td>
<td align="center" valign="middle">5.00&#x2009;&#x00B1;&#x2009;1.757</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle" colspan="3"><italic>Fall</italic></td>
<td align="center" valign="top"><italic>107.184</italic></td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="middle">No</td>
<td align="center" valign="middle">3,883 (90.53)</td>
<td align="center" valign="middle">4.34&#x2009;&#x00B1;&#x2009;1.488</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">A single fall</td>
<td align="center" valign="middle">286 (6.67)</td>
<td align="center" valign="middle">5.37&#x2009;&#x00B1;&#x2009;1.670</td>
<td/>
<td/>
</tr>
<tr>
<td align="left" valign="middle">Multiple falls</td>
<td align="center" valign="middle">120 (2.80)</td>
<td align="center" valign="middle">5.75&#x2009;&#x00B1;&#x2009;1.788</td>
<td/>
<td/>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec17">
<label>3.3.</label>
<title>Correlation analysis</title>
<p>Between the big five personality traits and fall, the correlation analysis presented that fall was negatively correlated with agreeableness (<italic>r&#x2009;=&#x2009;&#x2212;0.069</italic>, <italic>p &#x003C; 0.001</italic>) and conscientiousness (<italic>r&#x2009;=&#x2009;&#x2212;0.068</italic>, <italic>p &#x003C; 0.001</italic>); loneliness was positively correlated with neuroticism (<italic>r&#x2009;=&#x2009;0.085</italic>, <italic>p &#x003C; 0.001</italic>) and openness (<italic>r&#x2009;=&#x2009;0.039</italic>, <italic>p&#x2009;=&#x2009;0.011</italic>); fall was not correlated with extraversion (<italic>r&#x2009;=&#x2009;&#x2212;0.015</italic>, <italic>p&#x2009;=&#x2009;0.313</italic>).</p>
<p>Between the big five personality traits and loneliness scores, the correlation analysis presented that loneliness was negatively correlated with extraversion (<italic>r&#x2009;=&#x2009;&#x2212;0.130</italic>, <italic>p &#x003C; 0.001</italic>), agreeableness (<italic>r&#x2009;=&#x2009;&#x2212;0.192</italic>, <italic>p &#x003C; 0.001</italic>), and conscientiousness (<italic>r&#x2009;=&#x2009;&#x2212;0.181</italic>, <italic>p &#x003C; 0.001</italic>); loneliness was positively correlated with neuroticism (<italic>r&#x2009;=&#x2009;0.170</italic>, <italic>p &#x003C; 0.001</italic>); loneliness was not correlated with openness (<italic>r&#x2009;=&#x2009;&#x2212;0.029</italic>, <italic>p&#x2009;=&#x2009;0.058</italic>).</p>
</sec>
<sec id="sec18">
<label>3.4.</label>
<title>Multiple linear regression analysis</title>
<p>Multiple linear regression analysis was performed with loneliness as the dependent variable and agreeableness, conscientiousness, and neuroticism as mediating variables and fall as the independent variables. While age, marital status, education level, residence, and solitariness were controlling variables, as shown in <xref rid="tab2" ref-type="table">Table 2</xref>, agreeableness, conscientiousness, neuroticism, and fall were important influence risks for loneliness. After agreeableness, conscientiousness, neuroticism, and fall entered the model, <italic>&#x25B3;R<sup>2</sup></italic> increased by 5.8%. They were statistically significant with agreeableness (<italic>&#x03B2;&#x2009;=&#x2009;&#x2212;0.124, p&#x003C;0.001</italic>), conscientiousness (<italic>&#x03B2;&#x2009;=&#x2009;&#x2212;0.113</italic>, <italic>p &#x003C; 0.001</italic>), and neuroticism (<italic>&#x03B2;&#x2009;=&#x2009;0.170</italic>, <italic>p &#x003C; 0.001</italic>). In the meantime, the regression coefficient for fall decreased from 0.772 to 0.661 (<italic>p &#x003C; 0.001</italic>). There was a mediating effect with agreeableness, conscientiousness, and neuroticism.</p>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>Multiple linear regression (<italic>n</italic>&#x2009;=&#x2009;4,289).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" valign="top" colspan="2">Model 1</th>
<th align="center" valign="top" colspan="2">Model 2</th>
<th align="center" valign="top" colspan="2">Model 3</th>
</tr>
<tr>
<th/>
<th align="center" valign="top"><italic>&#x03B2;</italic>
</th>
<th align="center" valign="top"><italic>p</italic> value</th>
<th align="center" valign="top"><italic>&#x03B2;</italic>
</th>
<th align="center" valign="top"><italic>p</italic> value</th>
<th align="center" valign="top"><italic>&#x03B2;</italic>
</th>
<th align="center" valign="top"><italic>p</italic> value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">(Constant)</td>
<td align="center" valign="top">3.988</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">3.979</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">4.494</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top">Age</td>
<td align="center" valign="top">0.158</td>
<td align="center" valign="top">0.019</td>
<td align="center" valign="top">0.149</td>
<td align="center" valign="top">0.024</td>
<td align="center" valign="top">0.199</td>
<td align="center" valign="top">0.002</td>
</tr>
<tr>
<td align="left" valign="top">Marital status</td>
<td align="center" valign="top">0.121</td>
<td align="center" valign="top">0.001</td>
<td align="center" valign="top">0.113</td>
<td align="center" valign="top">0.002</td>
<td align="center" valign="top">0.143</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top">Education level</td>
<td align="center" valign="top">0.031</td>
<td align="center" valign="top">0.345</td>
<td align="center" valign="top">&#x2212;0.011</td>
<td align="center" valign="top">0.738</td>
<td align="center" valign="top">0.014</td>
<td align="center" valign="top">0.650</td>
</tr>
<tr>
<td align="left" valign="top">Residence</td>
<td align="center" valign="top">&#x2212;0.216</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">&#x2212;0.167</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">&#x2212;0.136</td>
<td align="center" valign="top">0.003</td>
</tr>
<tr>
<td align="left" valign="top">Solitary</td>
<td align="center" valign="top">0.552</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.492</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.386</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top">Fall</td>
<td/>
<td/>
<td align="center" valign="top">0.772</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.661</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top">Agreeableness</td>
<td/>
<td/>
<td/>
<td/>
<td align="center" valign="top">&#x2212;0.124</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top">Conscientiousness</td>
<td/>
<td/>
<td/>
<td/>
<td align="center" valign="top">&#x2212;0.113</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top">Neuroticism</td>
<td/>
<td/>
<td/>
<td/>
<td align="center" valign="top">0.170</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top"><italic>F</italic> value</td>
<td align="center" valign="top">26.616</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">53.934</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">69.994</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top"><italic>R</italic><sup>2</sup></td>
<td align="center" valign="top">0.030</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.070</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.128</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
<tr>
<td align="left" valign="top"><italic>&#x25B3;R</italic><sup>2</sup></td>
<td align="center" valign="top">0.030</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.040</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
<td align="center" valign="top">0.058</td>
<td align="center" valign="top"><italic>&#x003C;0.001</italic></td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec19">
<label>3.5.</label>
<title>Mediation model analysis</title>
<p>In this study, fall was set as the independent variable (<italic>X</italic>). When no fall was the reference group, <italic>X</italic>1 represented a single fall, and <italic>X</italic>2 represented multiple falls. Agreeableness (M1), conscientiousness (M2), and neuroticism (M3) were set as the mediating roles. Loneliness was set as the dependent variable (Y). As shown in <xref rid="tab3" ref-type="table">Table 3</xref>, the bootstrap&#x2019;s 95% CI of agreeableness, conscientiousness, and neuroticism did not overlap the zero; they had a significant mediating effect between fall and loneliness.</p>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption>
<p>The mediating effect between fall and loneliness through personality traits (<italic>n</italic>&#x2009;=&#x2009;4,289).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Effect</th>
<th align="center" valign="top" rowspan="2">Estimate</th>
<th align="center" valign="top" rowspan="2">Boot SE</th>
<th align="center" valign="top" colspan="2">Bootstrap 95%CI</th>
</tr>
<tr>
<th align="center" valign="top">Low</th>
<th align="center" valign="top">High</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Total effect (X1&#x2009;&#x2192;&#x2009;Y)</td>
<td align="center" valign="top">1.026</td>
<td align="center" valign="top">0.093</td>
<td align="center" valign="top">0.845</td>
<td align="center" valign="top">1.208</td>
</tr>
<tr>
<td align="left" valign="top">Total effect (X2&#x2009;&#x2192;&#x2009;Y)</td>
<td align="center" valign="top">1.406</td>
<td align="center" valign="top">0.140</td>
<td align="center" valign="top">1.132</td>
<td align="center" valign="top">1.680</td>
</tr>
<tr>
<td align="left" valign="top">X1&#x2009;&#x2192;&#x2009;M1&#x2009;&#x2192;&#x2009;Y</td>
<td align="center" valign="top">0.035<xref rid="tfn1" ref-type="table-fn"><sup>#</sup></xref></td>
<td align="center" valign="top">0.012</td>
<td align="center" valign="top">0.014</td>
<td align="center" valign="top">0.060</td>
</tr>
<tr>
<td align="left" valign="top">X2&#x2009;&#x2192;&#x2009;M1&#x2009;&#x2192;&#x2009;Y</td>
<td align="center" valign="top">0.055<xref rid="tfn1" ref-type="table-fn"><sup>#</sup></xref></td>
<td align="center" valign="top">0.020</td>
<td align="center" valign="top">0.019</td>
<td align="center" valign="top">0.095</td>
</tr>
<tr>
<td align="left" valign="top">X1&#x2009;&#x2192;&#x2009;M2&#x2009;&#x2192;&#x2009;Y</td>
<td align="center" valign="top">0.022<xref rid="tfn1" ref-type="table-fn"><sup>#</sup></xref></td>
<td align="center" valign="top">0.012</td>
<td align="center" valign="top">0.001</td>
<td align="center" valign="top">0.046</td>
</tr>
<tr>
<td align="left" valign="top">X2&#x2009;&#x2192;&#x2009;M2&#x2009;&#x2192;&#x2009;Y</td>
<td align="center" valign="top">0.071<xref rid="tfn1" ref-type="table-fn"><sup>#</sup></xref></td>
<td align="center" valign="top">0.020</td>
<td align="center" valign="top">0.034</td>
<td align="center" valign="top">0.111</td>
</tr>
<tr>
<td align="left" valign="top">X1&#x2009;&#x2192;&#x2009;M3&#x2009;&#x2192;&#x2009;Y</td>
<td align="center" valign="top">0.057<xref rid="tfn1" ref-type="table-fn"><sup>#</sup></xref></td>
<td align="center" valign="top">0.016</td>
<td align="center" valign="top">0.027</td>
<td align="center" valign="top">0.091</td>
</tr>
<tr>
<td align="left" valign="top">X2&#x2009;&#x2192;&#x2009;M3&#x2009;&#x2192;&#x2009;Y</td>
<td align="center" valign="top">0.113<xref rid="tfn1" ref-type="table-fn"><sup>#</sup></xref></td>
<td align="center" valign="top">0.026</td>
<td align="center" valign="top">0.065</td>
<td align="center" valign="top">0.169</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="tfn1">
<label>#</label>
<p>The mediating effect was significant.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec sec-type="discussions" id="sec20">
<label>4.</label>
<title>Discussion</title>
<p>In this study, for loneliness among older people, there are significant differences in age, marital status, education level, residence, solitariness, and fall. Many studies showed that age was significantly positively correlated with loneliness (<xref ref-type="bibr" rid="ref35">35</xref>, <xref ref-type="bibr" rid="ref36">36</xref>). People with older subjective ages might not be able to benefit as much from close social relationships as those with younger subjective ages in relieving loneliness (<xref ref-type="bibr" rid="ref36">36</xref>). Loneliness among the married was lower than among the unmarried, the divorced, and the widowed. When children grew up, they could spend less time caring for their parents. Older people will become more dependent on their spouses, who support each other. They could communicate and interact with each other to create a good family atmosphere. This can relieve loneliness to some extent (<xref ref-type="bibr" rid="ref37 ref38 ref39 ref40">37&#x2013;40</xref>). With regard to education level, this study implied that lower levels of loneliness showed up in those with a higher education level, which was consistent with other studies (<xref ref-type="bibr" rid="ref41">41</xref>, <xref ref-type="bibr" rid="ref42">42</xref>). In general, older people with a higher level of education are better at attending affairs and benefitting from more social resources to enhance their lives, which tends to make them experience less loneliness (<xref ref-type="bibr" rid="ref42">42</xref>). In our study, older people living in urban areas felt significantly less lonely than those living in rural areas. In China, rapid economic development led to a growing number of young people leaving villages to find employment elsewhere, leaving their parents to live alone as empty-nest older people (<xref ref-type="bibr" rid="ref42">42</xref>). Compared to their rural counterparts, older people who live in urban areas have greater access to healthcare services, technology, and facilities. By taking advantage of these resources, they have more opportunities to network with others, participate in social activities, volunteer, and attend senior colleges (<xref ref-type="bibr" rid="ref41">41</xref>). Solitariness is a significant risk factor for loneliness among older people all the time (<xref ref-type="bibr" rid="ref42">42</xref>, <xref ref-type="bibr" rid="ref43">43</xref>). As the old saying goes, &#x201C;The more children, the more happiness.&#x201D; Frequent contact and communication with family were critical in preventing and relieving loneliness (<xref ref-type="bibr" rid="ref42">42</xref>). Older people who have few or poor interpersonal relationships could experience more loneliness. Spouses and adult children would provide older people with social and emotional support to relieve their loneliness (<xref ref-type="bibr" rid="ref44">44</xref>).</p>
<p>We found that falls, only when they occurred one time, increased the loneliness of older people, which was consistent with other studies (<xref ref-type="bibr" rid="ref13">13</xref>, <xref ref-type="bibr" rid="ref15">15</xref>). It was reported that the fallen older people had a significant decrease in activity as a result of the fear of falling, which led to increased loneliness (<xref ref-type="bibr" rid="ref12">12</xref>). In the meantime, the higher level of loneliness will increase the fear of falls to a greater extent, which will increase the risk of falls (<xref ref-type="bibr" rid="ref45">45</xref>). This could lead to a vicious cycle. Falls may also increase the burden of caregivers, especially when they take care of people with complex needs (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref46">46</xref>). According to these reference studies, common conclusions included activity restrictions for managing the fear of falls and preventing falling (<xref ref-type="bibr" rid="ref46 ref47 ref48">46&#x2013;48</xref>). After a fall, older people would reduce social participation actively and caregivers would restrict activities, which increases dependence on caregivers further. In this situation, with fewer social interactions, loneliness will increase.</p>
<p>The current study showed agreeableness, conscientiousness, and neuroticism were meditating factors between falls and loneliness. There was a negative correlation between agreeableness and loneliness, which was consistent with another study (<xref ref-type="bibr" rid="ref23">23</xref>). Older people with higher agreeableness often have a more positive attitude and trust others more (<xref ref-type="bibr" rid="ref18">18</xref>). When they fall, they prefer to ask for social support and others&#x2019; help. That could relieve the loneliness effectively. There was a negative correlation between conscientiousness and loneliness. Higher conscientiousness often represents the ability to be prudent, responsible, and self-controlled (<xref ref-type="bibr" rid="ref18">18</xref>). A study indicated that higher conscientiousness was accompanied by higher adherence to adapting to healthy behaviors (<xref ref-type="bibr" rid="ref49">49</xref>). Therefore, older people with higher conscientiousness would pay more attention to their health and actively prevent falls. Although they fall, they often address it more actively rather than closing themselves off. There was a positive correlation between neuroticism and loneliness, which was consistent with other studies (<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref50">50</xref>). Older people with higher neuroticism are more sensitive to stressful events, which lead to emotional distress or even disorder. They are often unable to cope effectively with pressure and tend to close themselves off (<xref ref-type="bibr" rid="ref18">18</xref>). When they fall, whether injured or not, they blame themselves and gradually lose contact and restrict activities. As a result, they will experience social isolation and increased loneliness (<xref ref-type="bibr" rid="ref11">11</xref>, <xref ref-type="bibr" rid="ref12">12</xref>).</p>
<p>Although we have found that agreeableness, conscientiousness, and neuroticism were meditating factors between fall and loneliness, the mediating effect coefficient was a bit small. Therefore, we only explored the statistical significance. On the one hand, each big five personality trait was weekly correlated with falls and loneliness (/<italic>r</italic>/ <italic>&#x003C; 0.30</italic>, <italic>p &#x003C; 0.05</italic>) in this study. This result only implies a correlation between the three. If we want to explore the relationship and interplay, we should consider the longer-term changes because the big five personality traits remain stable over relatively short periods of time (<xref ref-type="bibr" rid="ref51">51</xref>). On the other hand, due to many demographic factors affecting loneliness (<xref ref-type="bibr" rid="ref3">3</xref>) and the complex relationship between the big five personality traits and loneliness (<xref ref-type="bibr" rid="ref23">23</xref>, <xref ref-type="bibr" rid="ref24">24</xref>), we need to exclude disruptions of relevant factors and make research to verify practical values in the future. In the meantime, it has been proven that interventions for social isolation made less effort to relieve loneliness (<xref ref-type="bibr" rid="ref52">52</xref>). We also explore the complex multi-factor between fall and loneliness. According to recent studies, when we make interventions for older people who have higher fall risks or have experienced falls, it is critical to consider the influence of the Big Five personality traits (<xref ref-type="bibr" rid="ref22">22</xref>, <xref ref-type="bibr" rid="ref24">24</xref>, <xref ref-type="bibr" rid="ref53">53</xref>).</p>
</sec>
<sec id="sec21">
<label>5.</label>
<title>Highlights and limitations</title>
<p>Older people who have experienced falls are more likely to feel lonely. At present, although the relationships among the variables of fall, loneliness, and personality trait have been examined separately, there was a lack of studies to explore the role of personality traits between falls and loneliness. This study indicated that agreeableness, conscientiousness, and neuroticism were significant mediating effects between falls and loneliness. Moreover, it was reported that interventions for social isolation made less effort to relieve loneliness. Therefore, for older people with different personality traits, in the future, interventions could make some adjustments according to distinctions between different personalities.</p>
<p>There were still some limitations that could be improved in future studies. First, self-report questionnaires were used in our study, and the ultra-short measure might be inadequate. Hence, the results of the questionnaire might be affected by participants&#x2019; subjective experiences and limited by insufficient assessment. Second, our data were collected during the summer, when older people responded to the questionnaire by their memories, leading to recall bias. Most of the older people were younger than 75&#x2009;years old, which had an impact on the results. Third, although this study indicated that agreeableness, conscientiousness, and neuroticism had significant mediating effects between falls and loneliness, the mediating effect coefficient was a bit small, partly due to the large sample size. Because the cross-sectional study did not allow for testing the temporal precedence of mediators and causality, in the future, research should explore practical applications. Finally, although our data were from the national level, the distribution of data on older people remained uneven in different regions. Therefore, the conclusions could only reflect certain issues from the side.</p>
</sec>
<sec sec-type="conclusions" id="sec22">
<label>6.</label>
<title>Conclusion</title>
<p>In this study, we found that there are significant differences in age, marital status, education level, residence, solitariness, and fall in relation to loneliness among older people. Falls, especially when they occurred one time increase the loneliness level of older people. This study implied that agreeableness, conscientiousness, and neuroticism were meditating factors between falls and loneliness. In the future, we should consider the big five personality traits more to understand loneliness and offer older people interventions to reduce their loneliness.</p>
</sec>
<sec sec-type="data-availability" id="sec23">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="sec24">
<title>Ethics statement</title>
<p>Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec id="sec25">
<title>Author contributions</title>
<p>LY, WY, and ZL: study design. LY, WY, DY, RH, and LJ: data collection. LY, DY, RH, and LJ: data analysis and article revision. LY: article writing. WY and ZL: article guide. All authors contributed to the article and approved the submitted version.</p>
</sec>
<sec sec-type="funding-information" id="sec26">
<title>Funding</title>
<p>This study was supported by the Hunan Natural Science Foundation (2021JJ70068).</p>
</sec>
<sec sec-type="COI-statement" id="sec27">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="sec100" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</body>
<back>
<ack>
<p>We appreciate the members of the Health Behavior and Health Promotion Lab for their help with collecting data.</p>
</ack>
<ref-list>
<title>References</title>
<ref id="ref1"><label>1.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ong</surname><given-names>AD</given-names></name> <name><surname>Uchino</surname><given-names>BN</given-names></name> <name><surname>Wethington</surname><given-names>E</given-names></name></person-group>. <article-title>Loneliness and health in older adults: a Mini-review and synthesis</article-title>. <source>Gerontology</source>. (<year>2016</year>) <volume>62</volume>:<fpage>443</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1159/000441651</pub-id>, PMID: <pub-id pub-id-type="pmid">26539997</pub-id></citation></ref>
<ref id="ref2"><label>2.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Song</surname><given-names>J</given-names></name> <name><surname>Wu</surname><given-names>H</given-names></name> <name><surname>Lan</surname><given-names>H</given-names></name> <name><surname>Xu</surname><given-names>D</given-names></name> <name><surname>Wang</surname><given-names>W</given-names></name></person-group>. <article-title>The influence of disease status on loneliness of the elderly: evidence from rural China</article-title>. <source>Int J Environ Res Public Health</source>. (<year>2022</year>) <volume>19</volume>:<fpage>3023</fpage>. doi: <pub-id pub-id-type="doi">10.3390/ijerph19053023</pub-id></citation></ref>
<ref id="ref3"><label>3.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>K</given-names></name> <name><surname>Victor</surname><given-names>CR</given-names></name></person-group>. <article-title>The prevalence of and risk factors for loneliness among older people in China</article-title>. <source>Ageing Soc</source>. (<year>2008</year>) <volume>28</volume>:<fpage>305</fpage>&#x2013;<lpage>27</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S0144686X07006848</pub-id></citation></ref>
<ref id="ref4"><label>4.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ju</surname><given-names>J</given-names></name> <name><surname>Qi</surname><given-names>WB</given-names></name> <name><surname>Zhang</surname><given-names>J</given-names></name> <name><surname>Cao</surname><given-names>ZJ</given-names></name> <name><surname>Tsai</surname><given-names>CL</given-names></name> <name><surname>Liu</surname><given-names>P</given-names></name></person-group>. <article-title>A cross-sectional study on the cross-talk of the COVID-19-related degree of loneliness and the etiological factors among the elderly in Central China</article-title>. <source>Front Psych</source>. (<year>2022</year>) <volume>13</volume>:<fpage>805664</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fpsyt.2022.805664</pub-id>, PMID: <pub-id pub-id-type="pmid">35237190</pub-id></citation></ref>
<ref id="ref5"><label>5.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Powell</surname><given-names>VD</given-names></name> <name><surname>Kumar</surname><given-names>N</given-names></name> <name><surname>Galecki</surname><given-names>AT</given-names></name> <name><surname>Kabeto</surname><given-names>M</given-names></name> <name><surname>Clauw</surname><given-names>DJ</given-names></name> <name><surname>Williams</surname><given-names>DA</given-names></name> <etal/></person-group>. <article-title>Bad company: loneliness longitudinally predicts the symptom cluster of pain, fatigue, and depression in older adults</article-title>. <source>J Am Geriatr Soc</source>. (<year>2022</year>) <volume>70</volume>:<fpage>2225</fpage>&#x2013;<lpage>34</lpage>. doi: <pub-id pub-id-type="doi">10.1111/jgs.17796</pub-id>, PMID: <pub-id pub-id-type="pmid">35415848</pub-id></citation></ref>
<ref id="ref6"><label>6.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Fox</surname><given-names>R</given-names></name> <name><surname>McHugh Power</surname><given-names>J</given-names></name> <name><surname>Coogan</surname><given-names>AN</given-names></name> <name><surname>Beekman</surname><given-names>ATF</given-names></name> <name><surname>van Tilburg</surname><given-names>TG</given-names></name> <name><surname>Hyland</surname><given-names>P</given-names></name></person-group>. <article-title>Posttraumatic stress disorder and loneliness are associated over time: a longitudinal study on PTSD symptoms and loneliness, among older adults</article-title>. <source>Psychiatry Res</source>. (<year>2021</year>) <volume>299</volume>:<fpage>113846</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.psychres.2021.113846</pub-id>, PMID: <pub-id pub-id-type="pmid">33706195</pub-id></citation></ref>
<ref id="ref7"><label>7.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Alasmawi</surname><given-names>K</given-names></name> <name><surname>Mann</surname><given-names>F</given-names></name> <name><surname>Lewis</surname><given-names>G</given-names></name> <name><surname>White</surname><given-names>S</given-names></name> <name><surname>Mezey</surname><given-names>G</given-names></name> <name><surname>Lloyd-Evans</surname><given-names>B</given-names></name></person-group>. <article-title>To what extent does severity of loneliness vary among different mental health diagnostic groups: a cross-sectional study</article-title>. <source>Int J Ment Health Nurs</source>. (<year>2020</year>) <volume>29</volume>:<fpage>921</fpage>&#x2013;<lpage>34</lpage>. doi: <pub-id pub-id-type="doi">10.1111/inm.12727</pub-id>, PMID: <pub-id pub-id-type="pmid">32356331</pub-id></citation></ref>
<ref id="ref8"><label>8.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kwan</surname><given-names>MM</given-names></name> <name><surname>Close</surname><given-names>JCT</given-names></name> <name><surname>Wong</surname><given-names>AKW</given-names></name> <name><surname>Lord</surname><given-names>SR</given-names></name></person-group>. <article-title>Falls incidence, risk factors, and consequences in Chinese older people: a systematic review</article-title>. <source>J Am Geriatr Soc</source>. (<year>2011</year>) <volume>59</volume>:<fpage>536</fpage>&#x2013;<lpage>43</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1532-5415.2010.03286.x</pub-id>, PMID: <pub-id pub-id-type="pmid">21361880</pub-id></citation></ref>
<ref id="ref9"><label>9.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jiang</surname><given-names>J</given-names></name> <name><surname>Long</surname><given-names>J</given-names></name> <name><surname>Ling</surname><given-names>W</given-names></name> <name><surname>Huang</surname><given-names>G</given-names></name> <name><surname>Guo</surname><given-names>X</given-names></name> <name><surname>Su</surname><given-names>L</given-names></name></person-group>. <article-title>Incidence of fall-related injury among old people in mainland China</article-title>. <source>Arch Gerontol Geriatr</source>. (<year>2015</year>) <volume>61</volume>:<fpage>131</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.archger.2015.06.003</pub-id>, PMID: <pub-id pub-id-type="pmid">26104752</pub-id></citation></ref>
<ref id="ref10"><label>10.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cheng</surname><given-names>P</given-names></name> <name><surname>Wang</surname><given-names>L</given-names></name> <name><surname>Ning</surname><given-names>P</given-names></name> <name><surname>Yin</surname><given-names>P</given-names></name> <name><surname>Schwebel</surname><given-names>DC</given-names></name> <name><surname>Liu</surname><given-names>J</given-names></name> <etal/></person-group>. <article-title>Unintentional falls mortality in China, 2006-2016</article-title>. <source>J Glob Health</source>. (<year>2019</year>) <volume>9</volume>:<fpage>010603</fpage>. doi: <pub-id pub-id-type="doi">10.7189/jogh.09.010603</pub-id>, PMID: <pub-id pub-id-type="pmid">30992985</pub-id></citation></ref>
<ref id="ref11"><label>11.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pin</surname><given-names>S</given-names></name> <name><surname>Spini</surname><given-names>D</given-names></name></person-group>. <article-title>Impact of falling on social participation and social support trajectories in a middle-aged and elderly European sample</article-title>. <source>SSM Popul Health</source>. (<year>2016</year>) <volume>2</volume>:<fpage>382</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.ssmph.2016.05.004</pub-id>, PMID: <pub-id pub-id-type="pmid">29349155</pub-id></citation></ref>
<ref id="ref12"><label>12.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Thomas</surname><given-names>SM</given-names></name> <name><surname>Parker</surname><given-names>A</given-names></name> <name><surname>Fortune</surname><given-names>J</given-names></name> <name><surname>Mitchell</surname><given-names>G</given-names></name> <name><surname>Hezam</surname><given-names>A</given-names></name> <name><surname>Jiang</surname><given-names>Y</given-names></name> <etal/></person-group>. <article-title>Global evidence on falls and subsequent social isolation in older adults: a scoping review</article-title>. <source>BMJ Open</source>. (<year>2022</year>) <volume>12</volume>:<fpage>e062124</fpage>. doi: <pub-id pub-id-type="doi">10.1136/bmjopen-2022-062124</pub-id>, PMID: <pub-id pub-id-type="pmid">36175106</pub-id></citation></ref>
<ref id="ref13"><label>13.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zeytinoglu</surname><given-names>M</given-names></name> <name><surname>Wroblewski</surname><given-names>KE</given-names></name> <name><surname>Vokes</surname><given-names>TJ</given-names></name> <name><surname>Huisingh-Scheetz</surname><given-names>M</given-names></name> <name><surname>Hawkley</surname><given-names>LC</given-names></name> <name><surname>Huang</surname><given-names>ES</given-names></name> <etal/></person-group>. <article-title>Association of Loneliness with Falls: a study of older US adults using the National Social Life, health, and aging project</article-title>. <source>Gerontol Geriatr Med</source>. (<year>2021</year>) <volume>7</volume>:<fpage>2333721421989217</fpage>. doi: <pub-id pub-id-type="doi">10.1177/2333721421989217</pub-id></citation></ref>
<ref id="ref14"><label>14.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>K</given-names></name> <name><surname>Wu</surname><given-names>S</given-names></name> <name><surname>Jang</surname><given-names>Y</given-names></name> <name><surname>Chou</surname><given-names>CP</given-names></name> <name><surname>Wilber</surname><given-names>KH</given-names></name> <name><surname>Aranda</surname><given-names>MP</given-names></name> <etal/></person-group>. <article-title>Longitudinal assessment of the relationships between geriatric conditions and loneliness</article-title>. <source>J Am Med Dir Assoc</source>. (<year>2021</year>) <volume>22</volume>:<fpage>1107</fpage>&#x2013;<lpage>1113.e1</lpage>. doi: <pub-id pub-id-type="doi">10.1016/j.jamda.2020.09.002</pub-id>, PMID: <pub-id pub-id-type="pmid">33071157</pub-id></citation></ref>
<ref id="ref15"><label>15.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bu</surname><given-names>F</given-names></name> <name><surname>Abell</surname><given-names>J</given-names></name> <name><surname>Zaninotto</surname><given-names>P</given-names></name> <name><surname>Fancourt</surname><given-names>D</given-names></name></person-group>. <article-title>A longitudinal analysis of loneliness, social isolation and falls amongst older people in England</article-title>. <source>Sci Rep</source>. (<year>2020</year>) <volume>10</volume>:<fpage>20064</fpage>. doi: <pub-id pub-id-type="doi">10.1038/s41598-020-77104-z</pub-id></citation></ref>
<ref id="ref16"><label>16.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hajek</surname><given-names>A</given-names></name> <name><surname>Konig</surname><given-names>HH</given-names></name></person-group>. <article-title>The association of falls with loneliness and social exclusion: evidence from the DEAS German ageing survey</article-title>. <source>BMC Geriatr</source>. (<year>2017</year>) <volume>17</volume>:<fpage>204</fpage>. doi: <pub-id pub-id-type="doi">10.1186/s12877-017-0602-5</pub-id>, PMID: <pub-id pub-id-type="pmid">28874139</pub-id></citation></ref>
<ref id="ref17"><label>17.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Petersen</surname><given-names>N</given-names></name> <name><surname>K&#x00F6;nig</surname><given-names>HH</given-names></name> <name><surname>Hajek</surname><given-names>A</given-names></name></person-group>. <article-title>The link between falls, social isolation and loneliness: a systematic review</article-title>. <source>Arch Gerontol Geriatr</source>. (<year>2020</year>) <volume>88</volume>:<fpage>104020</fpage>. doi: <pub-id pub-id-type="doi">10.1016/j.archger.2020.104020</pub-id>, PMID: <pub-id pub-id-type="pmid">32018091</pub-id></citation></ref>
<ref id="ref18"><label>18.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>McCrae</surname><given-names>RR</given-names></name></person-group>. <article-title>The five-factor model and its assessment in clinical settings</article-title>. <source>J Pers Assess</source>. (<year>1991</year>) <volume>57</volume>:<fpage>399</fpage>&#x2013;<lpage>414</lpage>. doi: <pub-id pub-id-type="doi">10.1207/s15327752jpa5703_2</pub-id></citation></ref>
<ref id="ref19"><label>19.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>McAdams</surname><given-names>DP</given-names></name></person-group>. <article-title>The five-factor model in personality: a critical appraisal</article-title>. <source>J Pers</source>. (<year>1992</year>) <volume>60</volume>:<fpage>329</fpage>&#x2013;<lpage>61</lpage>. doi: <pub-id pub-id-type="doi">10.1111/j.1467-6494.1992.tb00976.x</pub-id>, PMID: <pub-id pub-id-type="pmid">1635046</pub-id></citation></ref>
<ref id="ref20"><label>20.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Child</surname><given-names>S</given-names></name> <name><surname>Goodwin</surname><given-names>V</given-names></name> <name><surname>Garside</surname><given-names>R</given-names></name> <name><surname>Jones-Hughes</surname><given-names>T</given-names></name> <name><surname>Boddy</surname><given-names>K</given-names></name> <name><surname>Stein</surname><given-names>K</given-names></name></person-group>. <article-title>Factors influencing the implementation of fall-prevention programmes: a systematic review and synthesis of qualitative studies</article-title>. <source>Implement Sci</source>. (<year>2012</year>) <volume>7</volume>:<fpage>91</fpage>. doi: <pub-id pub-id-type="doi">10.1186/1748-5908-7-91</pub-id>, PMID: <pub-id pub-id-type="pmid">22978693</pub-id></citation></ref>
<ref id="ref21"><label>21.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Abdellaoui</surname><given-names>A</given-names></name> <name><surname>Chen</surname><given-names>HY</given-names></name> <name><surname>Willemsen</surname><given-names>G</given-names></name> <name><surname>Ehli</surname><given-names>EA</given-names></name> <name><surname>Davies</surname><given-names>GE</given-names></name> <name><surname>Verweij</surname><given-names>KJH</given-names></name> <etal/></person-group>. <article-title>Associations between loneliness and personality are mostly driven by a genetic association with neuroticism</article-title>. <source>J Pers</source>. (<year>2019</year>) <volume>87</volume>:<fpage>386</fpage>&#x2013;<lpage>97</lpage>. doi: <pub-id pub-id-type="doi">10.1111/jopy.12397</pub-id>, PMID: <pub-id pub-id-type="pmid">29752830</pub-id></citation></ref>
<ref id="ref22"><label>22.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Turunen</surname><given-names>KM</given-names></name> <name><surname>Kokko</surname><given-names>K</given-names></name> <name><surname>Kek&#x00E4;l&#x00E4;inen</surname><given-names>T</given-names></name> <name><surname>Al&#x00E9;n</surname><given-names>M</given-names></name> <name><surname>H&#x00E4;nninen</surname><given-names>T</given-names></name> <name><surname>Pynn&#x00F6;nen</surname><given-names>K</given-names></name> <etal/></person-group>. <article-title>Associations of neuroticism with falls in older adults: do psychological factors mediate the association?</article-title> <source>Aging Ment Health</source>. (<year>2022</year>) <volume>26</volume>:<fpage>77</fpage>&#x2013;<lpage>85</lpage>. doi: <pub-id pub-id-type="doi">10.1080/13607863.2020.1841735</pub-id>, PMID: <pub-id pub-id-type="pmid">33155480</pub-id></citation></ref>
<ref id="ref23"><label>23.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Schutter</surname><given-names>N</given-names></name> <name><surname>Koorevaar</surname><given-names>L</given-names></name> <name><surname>Holwerda</surname><given-names>TJ</given-names></name> <name><surname>Stek</surname><given-names>ML</given-names></name> <name><surname>Dekker</surname><given-names>J</given-names></name> <name><surname>Comijs</surname><given-names>HC</given-names></name></person-group>. <article-title>'Big Five' personality characteristics are associated with loneliness but not with social network size in older adults, irrespective of depression</article-title>. <source>Int Psychogeriatr</source>. (<year>2020</year>) <volume>32</volume>:<fpage>53</fpage>&#x2013;<lpage>63</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S1041610219000231</pub-id></citation></ref>
<ref id="ref24"><label>24.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Itzick</surname><given-names>M</given-names></name> <name><surname>Kagan</surname><given-names>M</given-names></name> <name><surname>Zychlinski</surname><given-names>E</given-names></name></person-group>. <article-title>The big five personality traits as predictors of loneliness among older men in Israel</article-title>. <source>J Psychol</source>. (<year>2020</year>) <volume>154</volume>:<fpage>60</fpage>&#x2013;<lpage>74</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00223980.2019.1653250</pub-id>, PMID: <pub-id pub-id-type="pmid">31524563</pub-id></citation></ref>
<ref id="ref25"><label>25.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Naseri</surname><given-names>C</given-names></name> <name><surname>McPhail</surname><given-names>SM</given-names></name> <name><surname>Haines</surname><given-names>TP</given-names></name> <name><surname>Morris</surname><given-names>ME</given-names></name> <name><surname>Shorr</surname><given-names>R</given-names></name> <name><surname>Etherton-Beer</surname><given-names>C</given-names></name> <etal/></person-group>. <article-title>Perspectives of older adults regarding barriers and enablers to engaging in fall prevention activities after hospital discharge</article-title>. <source>Health Soc Care Community</source>. (<year>2020</year>) <volume>28</volume>:<fpage>1710</fpage>&#x2013;<lpage>22</lpage>. doi: <pub-id pub-id-type="doi">10.1111/hsc.12996</pub-id>, PMID: <pub-id pub-id-type="pmid">32337796</pub-id></citation></ref>
<ref id="ref26"><label>26.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>YJ</given-names></name> <name><surname>Kaierdebieke</surname><given-names>A</given-names></name> <name><surname>Fan</surname><given-names>SY</given-names></name> <name><surname>Zhang</surname><given-names>RF</given-names></name> <name><surname>Huang</surname><given-names>MJ</given-names></name> <name><surname>Li</surname><given-names>H</given-names></name> <etal/></person-group>. <article-title>Study protocol: a cross-sectional study on psychology and behavior investigation of Chinese residents</article-title>. <source>PBICR Psychosom Med Res</source>. (<year>2022</year>) <volume>4</volume>:<fpage>13</fpage>&#x2013;<lpage>9</lpage>. doi: <pub-id pub-id-type="doi">10.53388/202219</pub-id></citation></ref>
<ref id="ref27"><label>27.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Carciofo</surname><given-names>R</given-names></name> <name><surname>Yang</surname><given-names>J</given-names></name> <name><surname>Song</surname><given-names>N</given-names></name> <name><surname>du</surname><given-names>F</given-names></name> <name><surname>Zhang</surname><given-names>K</given-names></name></person-group>. <article-title>Psychometric evaluation of Chinese-language 44-item and 10-item big five personality inventories, including correlations with Chronotype, mindfulness and mind wandering</article-title>. <source>PLoS One</source>. (<year>2016</year>) <volume>11</volume>:<fpage>e0149963</fpage>. doi: <pub-id pub-id-type="doi">10.1371/journal.pone.0149963</pub-id>, PMID: <pub-id pub-id-type="pmid">26918618</pub-id></citation></ref>
<ref id="ref28"><label>28.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gosling</surname><given-names>SD</given-names></name> <name><surname>Rentfrow</surname><given-names>PJ</given-names></name> <name><surname>Swann</surname><given-names>WB</given-names></name></person-group>. <article-title>A very brief measure of the big-five personality domains</article-title>. <source>J Res Pers</source>. (<year>2003</year>) <volume>37</volume>:<fpage>504</fpage>&#x2013;<lpage>28</lpage>. doi: <pub-id pub-id-type="doi">10.1016/S0092-6566(03)00046-1</pub-id></citation></ref>
<ref id="ref29"><label>29.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hughes</surname><given-names>ME</given-names></name> <name><surname>Waite</surname><given-names>LJ</given-names></name> <name><surname>Hawkley</surname><given-names>LC</given-names></name> <name><surname>Cacioppo</surname><given-names>JT</given-names></name></person-group>. <article-title>A short scale for measuring loneliness in large surveys: results from two population-based studies</article-title>. <source>Res Aging</source>. (<year>2004</year>) <volume>26</volume>:<fpage>655</fpage>&#x2013;<lpage>72</lpage>. doi: <pub-id pub-id-type="doi">10.1177/0164027504268574</pub-id>, PMID: <pub-id pub-id-type="pmid">18504506</pub-id></citation></ref>
<ref id="ref30"><label>30.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Russell</surname><given-names>DW</given-names></name></person-group>. <article-title>UCLA loneliness scale (version 3): reliability, validity, and factor structure</article-title>. <source>J Pers Assess</source>. (<year>1996</year>) <volume>66</volume>:<fpage>20</fpage>&#x2013;<lpage>40</lpage>. doi: <pub-id pub-id-type="doi">10.1207/s15327752jpa6601_2</pub-id>, PMID: <pub-id pub-id-type="pmid">8576833</pub-id></citation></ref>
<ref id="ref31"><label>31.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Dom&#x00E8;nech-Abella</surname><given-names>J</given-names></name> <name><surname>Lara</surname><given-names>E</given-names></name> <name><surname>Rubio-Valera</surname><given-names>M</given-names></name> <name><surname>Olaya</surname><given-names>B</given-names></name> <name><surname>Moneta</surname><given-names>MV</given-names></name> <name><surname>Rico-Uribe</surname><given-names>LA</given-names></name> <etal/></person-group>. <article-title>Loneliness and depression in the elderly: the role of social network</article-title>. <source>Soc Psychiatry Psychiatr Epidemiol</source>. (<year>2017</year>) <volume>52</volume>:<fpage>381</fpage>&#x2013;<lpage>90</lpage>. doi: <pub-id pub-id-type="doi">10.1007/s00127-017-1339-3</pub-id>, PMID: <pub-id pub-id-type="pmid">28154893</pub-id></citation></ref>
<ref id="ref32"><label>32.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>Z</given-names></name> <name><surname>Zhang</surname><given-names>D</given-names></name> <name><surname>Xu</surname><given-names>D</given-names></name> <name><surname>Li</surname><given-names>X</given-names></name> <name><surname>Xie</surname><given-names>YJ</given-names></name> <name><surname>Sun</surname><given-names>W</given-names></name> <etal/></person-group>. <article-title>Loneliness, depression, anxiety, and post-traumatic stress disorder among Chinese adults during COVID-19: a cross-sectional online survey</article-title>. <source>PLoS One</source>. (<year>2021</year>) <volume>16</volume>:<fpage>e0259012</fpage>. doi: <pub-id pub-id-type="doi">10.1371/journal.pone.0259012</pub-id>, PMID: <pub-id pub-id-type="pmid">34673812</pub-id></citation></ref>
<ref id="ref33"><label>33.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Preacher</surname><given-names>KJ</given-names></name> <name><surname>Hayes</surname><given-names>AF</given-names></name></person-group>. <article-title>SPSS and SAS procedures for estimating indirect effects in simple mediation models</article-title>. <source>Behav Res Methods Instrum Comput</source>. (<year>2004</year>) <volume>36</volume>:<fpage>717</fpage>&#x2013;<lpage>31</lpage>. doi: <pub-id pub-id-type="doi">10.3758/BF03206553</pub-id>, PMID: <pub-id pub-id-type="pmid">15641418</pub-id></citation></ref>
<ref id="ref34"><label>34.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hayes</surname><given-names>AF</given-names></name> <name><surname>Preacher</surname><given-names>KJ</given-names></name></person-group>. <article-title>Statistical mediation analysis with a multicategorical independent variable</article-title>. <source>Br J Math Stat Psychol</source>. (<year>2014</year>) <volume>67</volume>:<fpage>451</fpage>&#x2013;<lpage>70</lpage>. doi: <pub-id pub-id-type="doi">10.1111/bmsp.12028</pub-id>, PMID: <pub-id pub-id-type="pmid">24188158</pub-id></citation></ref>
<ref id="ref35"><label>35.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Xie</surname><given-names>J</given-names></name> <name><surname>Zhang</surname><given-names>B</given-names></name> <name><surname>Yao</surname><given-names>Z</given-names></name> <name><surname>Zhang</surname><given-names>W</given-names></name> <name><surname>Wang</surname><given-names>J</given-names></name> <name><surname>Zhao</surname><given-names>CN</given-names></name> <etal/></person-group>. <article-title>The effect of subjective age on loneliness in the old adults: the chain mediating role of resilience and self-esteem</article-title>. <source>Front Public Health</source>. (<year>2022</year>) <volume>10</volume>:<fpage>907934</fpage>. doi: <pub-id pub-id-type="doi">10.3389/fpubh.2022.907934</pub-id>, PMID: <pub-id pub-id-type="pmid">35983360</pub-id></citation></ref>
<ref id="ref36"><label>36.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Spitzer</surname><given-names>N</given-names></name> <name><surname>Segel-Karpas</surname><given-names>D</given-names></name> <name><surname>Palgi</surname><given-names>Y</given-names></name></person-group>. <article-title>Close social relationships and loneliness: the role of subjective age</article-title>. <source>Int Psychogeriatr</source>. (<year>2022</year>) <volume>34</volume>:<fpage>651</fpage>&#x2013;<lpage>5</lpage>. doi: <pub-id pub-id-type="doi">10.1017/S1041610219001790</pub-id>, PMID: <pub-id pub-id-type="pmid">31708003</pub-id></citation></ref>
<ref id="ref37"><label>37.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Segel-Karpas</surname><given-names>D</given-names></name> <name><surname>Ermer</surname><given-names>A</given-names></name></person-group>. <article-title>Cynical hostility and loneliness in older adult married couples: an indirect effect through friendships</article-title>. <source>J Gerontol B Psychol Sci Soc Sci</source>. (<year>2021</year>) <volume>76</volume>:<fpage>306</fpage>&#x2013;<lpage>16</lpage>. doi: <pub-id pub-id-type="doi">10.1093/geronb/gbaa170</pub-id>, PMID: <pub-id pub-id-type="pmid">33001205</pub-id></citation></ref>
<ref id="ref38"><label>38.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ben-Zur</surname><given-names>H</given-names></name></person-group>. <article-title>Loneliness, optimism, and well-being among married, divorced, and widowed individuals</article-title>. <source>J Psychol</source>. (<year>2012</year>) <volume>146</volume>:<fpage>23</fpage>&#x2013;<lpage>36</lpage>. doi: <pub-id pub-id-type="doi">10.1080/00223980.2010.548414</pub-id>, PMID: <pub-id pub-id-type="pmid">22303610</pub-id></citation></ref>
<ref id="ref39"><label>39.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ermer</surname><given-names>AE</given-names></name> <name><surname>Segel-Karpas</surname><given-names>D</given-names></name> <name><surname>Benson</surname><given-names>JJ</given-names></name></person-group>. <article-title>Loneliness trajectories and correlates of social connections among older adult married couples</article-title>. <source>J Fam Psychol</source>. (<year>2020</year>) <volume>34</volume>:<fpage>1014</fpage>&#x2013;<lpage>24</lpage>. doi: <pub-id pub-id-type="doi">10.1037/fam0000652</pub-id></citation></ref>
<ref id="ref40"><label>40.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Huang</surname><given-names>PH</given-names></name> <name><surname>Wang</surname><given-names>SY</given-names></name> <name><surname>Hu</surname><given-names>SH</given-names></name> <name><surname>Chuang</surname><given-names>YH</given-names></name></person-group>. <article-title>Older residents' perceptions of loneliness in long-term care facilities: a qualitative study</article-title>. <source>Int J Ment Health Nurs</source>. (<year>2022</year>) <volume>31</volume>:<fpage>601</fpage>&#x2013;<lpage>10</lpage>. doi: <pub-id pub-id-type="doi">10.1111/inm.12979</pub-id>, PMID: <pub-id pub-id-type="pmid">35118782</pub-id></citation></ref>
<ref id="ref41"><label>41.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>F</given-names></name> <name><surname>Gu</surname><given-names>D</given-names></name></person-group>. <article-title>Predictors of loneliness incidence in Chinese older adults from a life course perspective: a national longitudinal study</article-title>. <source>Aging Ment Health</source>. (<year>2020</year>) <volume>24</volume>:<fpage>879</fpage>&#x2013;<lpage>88</lpage>. doi: <pub-id pub-id-type="doi">10.1080/13607863.2018.1558174</pub-id>, PMID: <pub-id pub-id-type="pmid">30621448</pub-id></citation></ref>
<ref id="ref42"><label>42.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chang</surname><given-names>H</given-names></name> <name><surname>Huang</surname><given-names>Y</given-names></name> <name><surname>Liu</surname><given-names>X</given-names></name></person-group>. <article-title>Loneliness status and related factors among the Hakka elderly in Fujian, China: based on the health ecological model</article-title>. <source>J Environ Public Health</source>. (<year>2022</year>) <volume>2022</volume>:<fpage>2633297</fpage>. doi: <pub-id pub-id-type="doi">10.1155/2022/2633297</pub-id></citation></ref>
<ref id="ref43"><label>43.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Nyqvist</surname><given-names>F</given-names></name> <name><surname>Cattan</surname><given-names>M</given-names></name> <name><surname>Conradsson</surname><given-names>M</given-names></name> <name><surname>N&#x00E4;sman</surname><given-names>M</given-names></name> <name><surname>Gustafsson</surname><given-names>Y</given-names></name></person-group>. <article-title>Prevalence of loneliness over ten years among the oldest old</article-title>. <source>Scand J Public Health</source>. (<year>2017</year>) <volume>45</volume>:<fpage>411</fpage>&#x2013;<lpage>8</lpage>. doi: <pub-id pub-id-type="doi">10.1177/1403494817697511</pub-id>, PMID: <pub-id pub-id-type="pmid">28381194</pub-id></citation></ref>
<ref id="ref44"><label>44.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>G</given-names></name> <name><surname>Hu</surname><given-names>M</given-names></name> <name><surname>Xiao</surname><given-names>SY</given-names></name> <name><surname>Zhou</surname><given-names>L</given-names></name></person-group>. <article-title>Loneliness and depression among rural empty-nest elderly adults in Liuyang, China: a cross-sectional study</article-title>. <source>BMJ Open</source>. (<year>2017</year>) <volume>7</volume>:<fpage>e016091</fpage>. doi: <pub-id pub-id-type="doi">10.1136/bmjopen-2017-016091</pub-id>, PMID: <pub-id pub-id-type="pmid">28988166</pub-id></citation></ref>
<ref id="ref45"><label>45.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hajek</surname><given-names>A</given-names></name> <name><surname>Bock</surname><given-names>JO</given-names></name> <name><surname>Konig</surname><given-names>HH</given-names></name></person-group>. <article-title>Psychological correlates of fear of falling: findings from the German aging survey</article-title>. <source>Geriatr Gerontol Int</source>. (<year>2018</year>) <volume>18</volume>:<fpage>396</fpage>&#x2013;<lpage>406</lpage>. doi: <pub-id pub-id-type="doi">10.1111/ggi.13190</pub-id>, PMID: <pub-id pub-id-type="pmid">29143433</pub-id></citation></ref>
<ref id="ref46"><label>46.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Xu</surname><given-names>T</given-names></name> <name><surname>O&#x2019;Loughlin</surname><given-names>K</given-names></name> <name><surname>Clemson</surname><given-names>L</given-names></name> <name><surname>Lannin</surname><given-names>NA</given-names></name> <name><surname>Dean</surname><given-names>C</given-names></name> <name><surname>Koh</surname><given-names>G</given-names></name></person-group>. <article-title>Developing a falls prevention program for community-dwelling stroke survivors in Singapore: client and caregiver perspectives</article-title>. <source>Disabil Rehabil</source>. (<year>2019</year>) <volume>41</volume>:<fpage>1044</fpage>&#x2013;<lpage>54</lpage>. doi: <pub-id pub-id-type="doi">10.1080/09638288.2017.1419293</pub-id>, PMID: <pub-id pub-id-type="pmid">29277114</pub-id></citation></ref>
<ref id="ref47"><label>47.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Faes</surname><given-names>MC</given-names></name> <name><surname>Reelick</surname><given-names>MF</given-names></name> <name><surname>Joosten-Weyn Banningh</surname><given-names>LW</given-names></name> <name><surname>Gier</surname><given-names>M</given-names></name> <name><surname>Esselink</surname><given-names>RA</given-names></name> <name><surname>Olde Rikkert</surname><given-names>MG</given-names></name></person-group>. <article-title>Qualitative study on the impact of falling in frail older persons and family caregivers: foundations for an intervention to prevent falls</article-title>. <source>Aging Ment Health</source>. (<year>2010</year>) <volume>14</volume>:<fpage>834</fpage>&#x2013;<lpage>42</lpage>. doi: <pub-id pub-id-type="doi">10.1080/13607861003781825</pub-id>, PMID: <pub-id pub-id-type="pmid">20635232</pub-id></citation></ref>
<ref id="ref48"><label>48.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Est&#x00E9;vez-Guerra</surname><given-names>GJ</given-names></name> <name><surname>Fari&#x00F1;a-L&#x00F3;pez</surname><given-names>E</given-names></name> <name><surname>N&#x00FA;&#x00F1;ez-Gonz&#x00E1;lez</surname><given-names>E</given-names></name> <name><surname>Gandoy-Crego</surname><given-names>M</given-names></name> <name><surname>Calvo-Franc&#x00E9;s</surname><given-names>F</given-names></name> <name><surname>Capezuti</surname><given-names>EA</given-names></name></person-group>. <article-title>The use of physical restraints in long-term care in Spain: a multi-center cross-sectional study</article-title>. <source>BMC Geriatr</source>. (<year>2017</year>) <volume>17</volume>:<fpage>29</fpage>. doi: <pub-id pub-id-type="doi">10.1186/s12877-017-0421-8</pub-id>, PMID: <pub-id pub-id-type="pmid">28109267</pub-id></citation></ref>
<ref id="ref49"><label>49.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Linkievicz</surname><given-names>NM</given-names></name> <name><surname>Sgnaolin</surname><given-names>V</given-names></name> <name><surname>Engroff</surname><given-names>P</given-names></name> <name><surname>Behr Gomes Jardim</surname><given-names>G</given-names></name> <name><surname>Cataldo Neto</surname><given-names>A</given-names></name></person-group>. <article-title>Association between big five personality factors and medication adherence in the elderly</article-title>. <source>Trends Psychiatry Psychother</source>. (<year>2022</year>) <volume>44</volume>:<fpage>e20200143</fpage>. doi: <pub-id pub-id-type="doi">10.47626/2237-6089-2020-0143</pub-id></citation></ref>
<ref id="ref50"><label>50.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Beadle</surname><given-names>JN</given-names></name> <name><surname>Keady</surname><given-names>B</given-names></name> <name><surname>Brown</surname><given-names>V</given-names></name> <name><surname>Tranel</surname><given-names>D</given-names></name> <name><surname>Paradiso</surname><given-names>S</given-names></name></person-group>. <article-title>Trait empathy as a predictor of individual differences in perceived loneliness</article-title>. <source>Psychol Rep</source>. (<year>2012</year>) <volume>110</volume>:<fpage>3</fpage>&#x2013;<lpage>15</lpage>. doi: <pub-id pub-id-type="doi">10.2466/07.09.20.PR0.110.1.3-15</pub-id>, PMID: <pub-id pub-id-type="pmid">22489373</pub-id></citation></ref>
<ref id="ref51"><label>51.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Soto</surname><given-names>CJ</given-names></name> <name><surname>John</surname><given-names>OP</given-names></name> <name><surname>Gosling</surname><given-names>SD</given-names></name> <name><surname>Potter</surname><given-names>J</given-names></name></person-group>. <article-title>Age differences in personality traits from 10 to 65: big five domains and facets in a large cross-sectional sample</article-title>. <source>J Pers Soc Psychol</source>. (<year>2011</year>) <volume>100</volume>:<fpage>330</fpage>&#x2013;<lpage>48</lpage>. doi: <pub-id pub-id-type="doi">10.1037/a0021717</pub-id>, PMID: <pub-id pub-id-type="pmid">21171787</pub-id></citation></ref>
<ref id="ref52"><label>52.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tricco</surname><given-names>AC</given-names></name> <name><surname>Thomas</surname><given-names>SM</given-names></name> <name><surname>Radhakrishnan</surname><given-names>A</given-names></name> <name><surname>Ramkissoon</surname><given-names>N</given-names></name> <name><surname>Mitchell</surname><given-names>G</given-names></name> <name><surname>Fortune</surname><given-names>J</given-names></name> <etal/></person-group>. <article-title>Interventions for social isolation in older adults who have experienced a fall: a systematic review</article-title>. <source>BMJ Open</source>. (<year>2022</year>) <volume>12</volume>:<fpage>e056540</fpage>. doi: <pub-id pub-id-type="doi">10.1136/bmjopen-2021-056540</pub-id>, PMID: <pub-id pub-id-type="pmid">35264363</pub-id></citation></ref>
<ref id="ref53"><label>53.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Canada</surname><given-names>B</given-names></name> <name><surname>Stephan</surname><given-names>Y</given-names></name> <name><surname>Sutin</surname><given-names>AR</given-names></name> <name><surname>Terracciano</surname><given-names>A</given-names></name></person-group>. <article-title>Personality and falls among older adults: evidence from a longitudinal cohort</article-title>. <source>J Gerontol B Psychol Sci Soc Sci</source>. (<year>2020</year>) <volume>75</volume>:<fpage>1905</fpage>&#x2013;<lpage>10</lpage>. doi: <pub-id pub-id-type="doi">10.1093/geronb/gbz040</pub-id></citation></ref>
</ref-list>
</back>
</article>