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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2022.840678</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Prevalence and 10-Year Stability of Personality Disorders From Adolescence to Young Adulthood in a High-Risk Sample</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>d&#x2019;Huart</surname> <given-names>Delfine</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1322104/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Steppan</surname> <given-names>Martin</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/906395/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Seker</surname> <given-names>S&#x00FC;heyla</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1699221/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>B&#x00FC;rgin</surname> <given-names>David</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/580314/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Boonmann</surname> <given-names>Cyril</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/601402/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Birkh&#x00F6;lzer</surname> <given-names>Marc</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1105312/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Jenkel</surname> <given-names>Nils</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1699338/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Fegert</surname> <given-names>J&#x00F6;rg M.</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1125504/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Schmid</surname> <given-names>Marc</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/820546/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Schmeck</surname> <given-names>Klaus</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/720428/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Department of Child and Adolescent Psychiatric Research, University Psychiatric Clinics Basel</institution>, <addr-line>Basel</addr-line>, <country>Switzerland</country></aff>
<aff id="aff2"><sup>2</sup><institution>Division of Developmental and Personality Psychology, University of Basel</institution>, <addr-line>Basel</addr-line>, <country>Switzerland</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Child and Adolescent Psychiatry and Psychotherapy</institution>, <addr-line>Ulm University, Ulm</addr-line>, <country>Germany</country></aff>
<aff id="aff4"><sup>4</sup><institution>Department of Forensic Child and Adolescent Psychiatry, University Psychiatric Clinics Basel</institution>, <addr-line>Basel</addr-line>, <country>Switzerland</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Amanda Venta, University of Houston, United States</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Say How Ong, Institute of Mental Health, Singapore; Joost Hutsebaut, University of Antwerp, Belgium</p></fn>
<corresp id="c001">&#x002A;Correspondence: Delfine d&#x2019;Huart Delfine.d&#x2019;<email>Huart@upk.ch</email></corresp>
<fn fn-type="other" id="fn004"><p>This article was submitted to Child and Adolescent Psychiatry, a section of the journal Frontiers in Psychiatry</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>24</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="collection">
<year>2022</year>
</pub-date>
<volume>13</volume>
<elocation-id>840678</elocation-id>
<history>
<date date-type="received">
<day>21</day>
<month>12</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>02</month>
<year>2022</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2022 d&#x2019;Huart, Steppan, Seker, B&#x00FC;rgin, Boonmann, Birkh&#x00F6;lzer, Jenkel, Fegert, Schmid and Schmeck.</copyright-statement>
<copyright-year>2022</copyright-year>
<copyright-holder>d&#x2019;Huart, Steppan, Seker, B&#x00FC;rgin, Boonmann, Birkh&#x00F6;lzer, Jenkel, Fegert, Schmid and Schmeck</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) in early 2022, there will be a radical change in the framework and process for diagnosing personality disorders (PDs), indicating a transition from the categorical to the dimensional model. Despite increasing evidence that PDs are not as stable as previously assumed, the long-term stability of PDs remains under major debate. The aim of the current paper was to investigate the categorical and dimensional mean-level and rank-order stability of PDs from adolescence into young adulthood in a high-risk sample.</p>
</sec>
<sec>
<title>Methods</title>
<p>In total, 115 young adults with a history of residential child welfare and juvenile-justice placements in Switzerland were included in the current study. PDs were assessed at baseline and at a 10-year follow-up. On a categorical level, mean-level stability was assessed through the proportion of enduring cases from baseline to follow-up. Rank-order stability was assessed through Cohen&#x2019;s &#x03BA; and tetrachoric correlation coefficients. On a dimensional level, the magnitude of change between the PD trait scores at baseline and at follow-up was measured by Cohen&#x2019;s <italic>d</italic>. Rank-order stability was assessed through Spearman&#x2019;s &#x03C1;.</p>
</sec>
<sec>
<title>Results</title>
<p>The prevalence rate for any PD was 20.0% at baseline and 30.4% at follow-up. The most frequently diagnosed disorders were antisocial, borderline, and obsessive-compulsive PDs, both at baseline and at follow-up. On a categorical level, the mean-level stability of any PD was only moderate, and the mean-level stability of specific PDs was low, except of schizoid PD. Likewise, the rank-order stability of any PD category was moderate, while ranging from low to high for individual PD diagnoses. On a dimensional level, scores increased significantly for most PDs, except for histrionic traits, which decreased significantly from baseline to follow-up. Effect sizes were generally low. The rank-order stability for dimensional scores ranged from low to moderate.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>The findings indicate low to moderate stability of Pds and Pd traits from adolescence to adulthood, which supports the growing evidence that categorical diagnoses of Pds are quite unstable. This in turn, emphasizes the use of the upcoming ICD-11 that Acknowledgments Pds to be only &#x201C;relatively&#x201D; stable.</p>
</sec>
</abstract>
<kwd-group>
<kwd>personality disorders <bold>(PDs)</bold></kwd>
<kwd>prevalence</kwd>
<kwd>stability</kwd>
<kwd>high-risk sample</kwd>
<kwd>youth</kwd>
</kwd-group>
<contract-sponsor id="cn001">Bundesamt f&#x00FC;r Justiz<named-content content-type="fundref-id">10.13039/501100013926</named-content></contract-sponsor>
<contract-sponsor id="cn002">Fonds National de la Recherche Luxembourg<named-content content-type="fundref-id">10.13039/501100001866</named-content></contract-sponsor>
<counts>
<fig-count count="0"/>
<table-count count="5"/>
<equation-count count="0"/>
<ref-count count="70"/>
<page-count count="11"/>
<word-count count="9488"/>
</counts>
</article-meta>
</front>
<body>
<sec id="S1" sec-type="intro">
<title>Introduction</title>
<p>The introduction of personality disorders (PDs) in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) (<xref ref-type="bibr" rid="B1">1</xref>) led to a substantial increase in empirical research and clinical interest (<xref ref-type="bibr" rid="B2">2</xref>). Yet, the advent of specific diagnostic criteria and a multiaxial approach that differentiated PDs (i.e., Axis II) from clinical syndromes (i.e., Axis I) set the stage for an ongoing controversy about the conceptualization and diagnosis of PDs. While PDs were defined as discrete, distinct categories, the shortcomings of such a categorical classification model became quickly apparent (<xref ref-type="bibr" rid="B3">3</xref>&#x2013;<xref ref-type="bibr" rid="B5">5</xref>), and a shift to a more dimensional model, in which PDs are perceived as extreme variants of normal personality dimensions, became inevitable (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B7">7</xref>). With the upcoming 11th edition of the International Classification of Diseases (ICD-11) (<xref ref-type="bibr" rid="B8">8</xref>), the conceptualization of PDs is finally in transition, acknowledging PDs to be only &#x201C;relatively&#x201D; stable (<xref ref-type="bibr" rid="B9">9</xref>&#x2013;<xref ref-type="bibr" rid="B11">11</xref>). For over decades, however, temporal stability consisted in one of the major distinguishing features between Axis I and Axis II disorders with the stability of PDs being substantially higher than for other mental disorders. Yet cumulative findings slowly appeared to question the stability of PDs, by suggesting considerable improvement over time (<xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B13">13</xref>). Thus, against the common assumption that PDs are &#x201C;enduring,&#x201D; &#x201C;inflexible,&#x201D; and &#x201C;stable&#x201D; the categorical stability of PDs has found to be not much higher than the stability of other mental disorders (<xref ref-type="bibr" rid="B14">14</xref>). Indeed, the Collaborative Longitudinal Study of PDs (CLPS) (<xref ref-type="bibr" rid="B15">15</xref>), which investigated the stability of schizotypal, borderline, avoidant, and obsessive-compulsive PDs over time, found that fewer than half of PD patients still met the criteria for a diagnosis after 2 years (<xref ref-type="bibr" rid="B16">16</xref>). With regard to borderline PD (BPD), 85% of the original sample had remitted after 10 years (<xref ref-type="bibr" rid="B17">17</xref>).</p>
<p>Nevertheless, as outlined in Morey and Hopwood&#x2019;s narrative review (<xref ref-type="bibr" rid="B18">18</xref>), temporal stability is a complex notion and has to be examined with respect to several factors. First, estimates tend to vary as a function of the type of stability being assessed. In the present study, the focus relies on the two types of stability that have been studied most frequently, namely mean-level and rank-order stability. Mean-level stability refers to the degree to which the average level of a PD or a PD trait in a given sample changes over time. Rank-order stability, on the other hand, refers to the consistency of an individual&#x2019;s relative ordering compared to others in a given sample, capturing, thus, the extent to which interindividual differences persist over time (<xref ref-type="bibr" rid="B18">18</xref>). Rank-order stability is high if the participants in a given sample maintain their ordering with regard to a specific PD or PD trait relative to each other over time, even if the sample as a whole increases or decreases with regard to that PD or PD trait. As such, rank-order changes are independent of mean-level changes (<xref ref-type="bibr" rid="B19">19</xref>). Second, estimates depend in part on the type of PD construct being assessed (i.e., categories or traits), suggesting higher stability for dimensional traits rather than for distinct categories (<xref ref-type="bibr" rid="B20">20</xref>&#x2013;<xref ref-type="bibr" rid="B22">22</xref>). In their narrative review, Grilo and McGlashan (<xref ref-type="bibr" rid="B21">21</xref>) reported that the rank-order stability for meeting any PD diagnosis is fair to moderate, while individual PD diagnoses often exhibit lower stability. In contrast, dimensional scores tend to show slightly higher stability estimates. Durbin and Klein (<xref ref-type="bibr" rid="B20">20</xref>) confirmed these findings by showing that rank-order stability was low to fair for categorical PD diagnoses over a 10-year follow-up in depressed outpatients, while rank-order stability for dimensional PD traits was fair to moderate. According to Grilo et al. (<xref ref-type="bibr" rid="B23">23</xref>), mean-level stability, when assessed dimensionally, is generally lower than rank-order stability, which indicates that symptoms tend to decrease on average, but the rank-ordering of individuals within a defined sample remains roughly the same. Third, estimates may be affected by the assessment method being used to measure PDs. Self-report questionnaires tend to show a relatively higher stability than clinical interviews (<xref ref-type="bibr" rid="B20">20</xref>, <xref ref-type="bibr" rid="B24">24</xref>). For instance, the findings from Samuel et al. (<xref ref-type="bibr" rid="B22">22</xref>) for dimensional ratings showed significantly greater rank-order and mean-level stability for self-report questionnaires compared to clinical interviews. Findings regarding categorical PD diagnoses, in contrast, indicated comparable rank-order and mean-level stability. Finally, Morey and Hopwood (<xref ref-type="bibr" rid="B18">18</xref>) outlined how the clinical status and age range of a given sample are critical factors affecting PD stability estimates over time. Studies investigating the course of PDs, however, seem to focus mainly on adult samples, and studies on children and adolescents are scarce. This paucity of research has been in part due to the widespread reluctance to diagnose PDs in youth (<xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B26">26</xref>) and to the belief that personality in adolescence is inconstant and characterized by emotional outbursts and impulsive behavior (<xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B28">28</xref>). Existing literature, however, clearly states that PDs can be validly and reliably diagnosed among juveniles (<xref ref-type="bibr" rid="B27">27</xref>, <xref ref-type="bibr" rid="B28">28</xref>) and that the stability of PDs in adolescence is found to be comparable to the stability in adulthood (<xref ref-type="bibr" rid="B29">29</xref>, <xref ref-type="bibr" rid="B30">30</xref>).</p>
<p>Given the apparent number of developmental tasks [e.g., achieving emotional independence from parents, developing close relationships with peers, preparing for a professional occupation (<xref ref-type="bibr" rid="B31">31</xref>)], the transition from adolescence to adulthood seems to be a salient period for investigating the stability of PDs (<xref ref-type="bibr" rid="B18">18</xref>, <xref ref-type="bibr" rid="B32">32</xref>). To the best of our knowledge, however, only two studies have explicitly investigated the stability of PDs from adolescence to early adulthood. The Children in the Community (CIC) study investigated the stability of PD traits in a community sample ranging in age from 9 to 28 (<xref ref-type="bibr" rid="B33">33</xref>). Findings show that mean PD traits were highest in adolescence and declined linearly to adulthood, although effect sizes were small. Rank-order stability was found to be low to moderate, and cluster C traits seemed to be less stable than cluster A and B traits (<xref ref-type="bibr" rid="B34">34</xref>). Similarly, Bornovalova et al. (<xref ref-type="bibr" rid="B35">35</xref>), who investigated the stability and heritability of BPD in a community sample, showed a significant mean-level decline from age 14 to 24, although rank-order stability was high. A third study, namely the study from Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>), investigated the 2-year stability of PDs in older adolescent outpatients, aged 15&#x2013;18 years, and found that 74% of those diagnosed with a PD at baseline still met the criteria for a PD at follow-up. Regarding dimensional ratings, both rank-order and mean-level stability ranged from low (PD NOS) to moderate (borderline, histrionic, and schizotypal) to high (antisocial and schizoid) (<xref ref-type="bibr" rid="B36">36</xref>).</p>
<p>Given the apparent role of developmental influences on the etiology of PDs, studies about the stability of PDs in high-risk samples are surprisingly lacking. The aim of the present study was therefore to examine the prevalence of PDs and their stability over a 10-year period from adolescence to adulthood in adolescents placed in residential care and juvenile-justice institutions. Due to multiple risk factors &#x2013; such as childhood adversities (<xref ref-type="bibr" rid="B37">37</xref>), unfavorable parenting practices, low socioeconomic status, parental mental disorders (<xref ref-type="bibr" rid="B38">38</xref>), early mental-health problems (e.g., ADHD, oppositional defiant disorders, and attachment disorders), symptoms of depression and anxiety (<xref ref-type="bibr" rid="B39">39</xref>), substance use (<xref ref-type="bibr" rid="B40">40</xref>), self-harming behavior (<xref ref-type="bibr" rid="B41">41</xref>), psychopathic traits, and youth delinquency (<xref ref-type="bibr" rid="B42">42</xref>) &#x2013; adolescents in residential care and juvenile-justice institutions are particularly at risk of developing a PD, and PD prevalence rates among them are high, ranging from 18 to 40% across studies (<xref ref-type="bibr" rid="B43">43</xref>&#x2013;<xref ref-type="bibr" rid="B45">45</xref>). To account for conceptual and methodological factors, both categorical and dimensional mean-level and rank-order stability were investigated.</p>
</sec>
<sec id="S2" sec-type="materials|methods">
<title>Materials and Methods</title>
<sec id="S2.SS1">
<title>Study Design</title>
<sec id="S2.SS1.SSS1">
<title>Baseline</title>
<p>Data was obtained from the longitudinal &#x201C;Swiss Study for Clarification and Goal-Attainment in Child Welfare and Juvenile-Justice Institutions&#x201D; [German: Modellversuch zur Abkl&#x00E4;rung und Zielerreichung in station&#x00E4;ren Massnahmen (MAZ)] (<xref ref-type="bibr" rid="B46">46</xref>). The study was conducted between 2007 and 2011 with the primary aims of describing the mental health of children and adolescents in residential care and of investigating the effects of residential youth care over an approximately 1-year period in Switzerland. Child welfare and juvenile-justice institutions accredited by the Swiss Federal Ministry of Justice were invited to participate, of which 64 institutions agreed to take part. Juveniles who had been living for at least 1 month in 1 of these 64 included child welfare and juvenile justice institutions and possessed sufficient language skills in German, French, or Italian as well as sufficient intelligence scores (IQ &#x003E; 70) were eligible for participation. The juveniles had been placed in the child welfare and juvenile-justice institutions by penal law, by civil law, or voluntarily. Both voluntary placement and placement by civil law were due to severe mental distress or precarious living conditions. Prior to participation, juveniles, parents or legal guardians, and social workers were asked to provide informed consent. Participants then completed computer-administered questionnaires as well as semistructured clinical interviews regarding mental health, psychosocial problems, and offending behavior. Assessment was conducted by trained psychologists and research assistants. Overall, 592 children and adolescents aged 6&#x2013;26 years (mean age = 16.3 years) participated at baseline. Of those participants, 511 agreed to be contacted for a possible follow-up study. The study procedure was approved by the Ethics Committees on Research Involving Humans at the University of Basel and the University of Lausanne (Switzerland) and by the Institutional Review Board at the Ulm University (Germany).</p>
</sec>
<sec id="S2.SS1.SSS2">
<title>Follow-Up</title>
<p>After a follow-up period of approximately 10 years, participants were reassessed in the study &#x201C;Youth Welfare Trajectories: Learning from Experiences&#x201D; [German: Jugendhilfeverl&#x00E4;ufe: Aus Erfahrung Lernen (JAEL)], which is currently being conducted to examine participants&#x2019; psychosocial development over time and their transition out of care. Participants were contacted by postal mail, phone, email, and social media. Of the 511 participants, 231 (45.2%) agreed to participate in the follow-up. Despite considerable efforts, 8 (1.6%) participants could not be located, 121 (23.7%) could not be reached, 99 (19.4%) refused to participate, 44 (8.6%) did not provide informed consent, and 8 (1.6%) were deceased. A study flow-chart is provided in <xref ref-type="supplementary-material" rid="DS1">Supplementary Figure 1</xref>. An analysis of the sample attrition showed no significant differences in sociodemographic features (i.e., age, gender, number of former placements, and average duration in residential care) between the participants who took part in the follow-up and those who did not. The follow-up assessment consisted primarily of a set of online questionnaires that participants could complete from home. Participants were then invited to a face-to-face meeting, where they were reassessed using semistructured clinical interviews and semistructured qualitative in-depth interviews regarding mental health, psychosocial problems, and offending behavior. Assessment was conducted by trained psychologists, doctoral students, and research assistants. The study procedure was approved by the Ethics Committee Northwestern and Central Switzerland (EKNZ, Ref.: 2017-00718).</p>
</sec>
</sec>
<sec id="S2.SS2">
<title>Participants</title>
<p>As the primary aim of this study was to investigate the stability of PDs from adolescence to adulthood, only participants with complete data from the Structured Clinical Interview for DSM-IV-TR Axis II Personality Disorders (SCID-II) (<xref ref-type="bibr" rid="B47">47</xref>) at baseline and at follow-up were included, which left a study sample of 138 participants. In addition, participants younger than 12 years of age or older than 18 years at baseline were excluded. The final sample included 115 participants (39.13% female) with a mean age of 15.82 (<italic>SD</italic> = 1.93; range 12&#x2013;18) at baseline and a mean age of 25.89 (<italic>SD</italic> = 2.18; range = 21&#x2013;30) at follow-up (<xref ref-type="table" rid="T1">Table 1</xref>). Excluded participants revealed no statistically significant differences from participants at baseline in age [<italic>t</italic>(169) = -1.54; <italic>p</italic> = 0.126], gender [&#x03C7;<sup>2</sup>(1) = 0.002; <italic>p</italic> = 0.964], number of placements in residential care [<italic>t</italic>(551) = 0.40; <italic>p</italic> = 0.689], average duration in residential care [<italic>t</italic>(228) = -0.19; <italic>p</italic> = 0.849], PDs [&#x03C7;<sup>2</sup>(1) = 2.41; <italic>p</italic> = 0.120], and mental-health problems other than PDs [&#x03C7;<sup>2</sup>(1) = 0.56; <italic>p</italic> = 0.451].</p>
<table-wrap position="float" id="T1">
<label>TABLE 1</label>
<caption><p>Sample characteristics at baseline and follow-up (<italic>N</italic> = 115).</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="center">Baseline</td>
<td valign="top" align="center">Follow-up</td>
</tr>
<tr>
<td valign="top" align="center"></td>
<td valign="top" align="center" colspan="2"><hr/></td>
</tr>
<tr>
<td/>
<td valign="top" align="center"><italic>M (SD)</italic></td>
<td valign="top" align="center"><italic>M (SD)</italic></td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Age (years)</td>
<td valign="top" align="center">15.8 (1.9)</td>
<td valign="top" align="center">25.9 (2.2)</td>
</tr>
<tr>
<td valign="top" align="left">Number of placements in residential care</td>
<td valign="top" align="center">0.7 (1.0)</td>
<td valign="top" align="center">3.4 (2.8)</td>
</tr>
<tr>
<td valign="top" align="left">Average duration in residential care (years)</td>
<td valign="top" align="center">1.4 (1.7)</td>
<td valign="top" align="center">6.3 (4.8)</td>
</tr>
<tr>
<td/>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
</tr>
<tr>
<td valign="top" align="left">Gender (female)</td>
<td valign="top" align="center">45 (39.1)</td>
<td valign="top" align="center">45 (39.1)</td>
</tr>
<tr>
<td valign="top" align="left"><bold>Current mental-health disorders<xref ref-type="table-fn" rid="t1fna"><sup>a</sup></xref></bold></td>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Any current mental-health disorder</td>
<td valign="top" align="center">74 (64.9)</td>
<td valign="top" align="center">64 (55.6)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;ADHD<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">13 (11.4)</td>
<td valign="top" align="center">24 (20.9)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Anxiety disorder<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">29 (25.4)</td>
<td valign="top" align="center">19 (16.5)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Conduct disorder<sup>b,c</sup></td>
<td valign="top" align="center">34 (29.8)</td>
<td/>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Mood disorder<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">16 (14.0)</td>
<td valign="top" align="center">22 (19.1)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Personality disorder</td>
<td valign="top" align="center">23 (20.0)</td>
<td valign="top" align="center">35 (30.4)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Psychotic disorder<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">2 (1.7)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;PTSD<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">5 (4.4)</td>
<td valign="top" align="center">6 (5.2)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2003;Substance-use disorder<xref ref-type="table-fn" rid="t1fnb"><sup>b</sup></xref></td>
<td valign="top" align="center">17 (14.9)</td>
<td valign="top" align="center">41 (35.6)</td>
</tr>
<tr>
<td valign="top" align="left">Current mental-health treatment<xref ref-type="table-fn" rid="t1fnb"><sup>d</sup></xref></td>
<td valign="top" align="center">55 (61.1)</td>
<td valign="top" align="center">27 (23.5)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t1fna"><p><italic><sup>a</sup>Participants with multiple mental-health disorders are displayed more than once.</italic></p></fn>
<fn id="t1fnb"><p><italic><sup>b</sup>Due to missing data, the sample size at baseline was N = 114. <sup>c</sup>Only available at baseline. <sup>d</sup>Due to missing data, the sample size at baseline was N = 90.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="S2.SS3">
<title>Measurements</title>
<sec id="S2.SS3.SSS1">
<title>Sociodemographic Characteristics</title>
<p>Sociodemographic information &#x2013; age, gender, number of former placements, average duration in residential care (i.e., total time spent in residential care and juvenile-justice institutions), and current mental-health treatment &#x2013; was collected using a computer-based questionnaire at baseline and at follow-up. Participants&#x2019; data on social welfare, disability, and unemployment insurance were only assessed at follow-up.</p>
</sec>
<sec id="S2.SS3.SSS2">
<title>Mental Disorders</title>
<p>Mental disorders at baseline were assessed with the Schedule for Affective Disorders and Schizophrenia for School-Age Children &#x2013; Present and Lifetime Version (K-SADS-PL) (<xref ref-type="bibr" rid="B48">48</xref>). The K-SADS-PL is a semistructured clinical interview that provides a reliable and valid measurement of DSM-IV diagnoses in children and adolescents. At follow-up, mental disorders were examined with the Structured Clinical Interview for DSM-5 Disorders &#x2013; Clinician Version (SCID-5-CV) (<xref ref-type="bibr" rid="B49">49</xref>). The SCID-5-CV is a semistructured clinical interview based on DSM-5 diagnoses covering the most common diagnoses seen in clinical settings: depressive and bipolar disorders, schizophrenia spectrum and other psychotic disorders, substance-use disorders, anxiety disorders, obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), attention-deficit hyperactivity disorder (ADHD), and adjustment disorder. In addition, the SCID-5-CV screens for 17 additional DSM-5 diagnoses. Items and diagnoses are scored based on dichotomous &#x201C;present&#x201D; and &#x201C;absent&#x201D; response options. The SCID-5-CV presents excellent reliability, with Cohen&#x2019;s &#x03BA; ranging from 0.70 to 0.75 (<xref ref-type="bibr" rid="B50">50</xref>).</p>
</sec>
<sec id="S2.SS3.SSS3">
<title>Personality Disorders</title>
<p>Personality disorders were assessed at baseline and at follow-up using the SCID-II (<xref ref-type="bibr" rid="B47">47</xref>). The SCID-II is a semistructured interview designed to yield PD diagnoses based on the DSM-IV and DSM-IV-TR (i.e., paranoid, schizoid, schizotypal, histrionic, borderline, antisocial, narcissistic, avoidant, dependent, obsessive-compulsive, depressive, and passive-aggressive PDs) and consists of 134 items, which are rated on a 3-point Likert scale (1 = absent, 2 = subthreshold, and 3 = threshold). Since depressive and passive-aggressive PDs were removed in the DSM-5, both disorders were included in the PD NOS section in the following analyses. Categorical diagnoses are provided according to the specific diagnostic thresholds of PDs the DSM-IV. Dimensional scores are provided by summing the scores from each individual item for each separate PD. Interrater reliability for categorical diagnoses varies from 0.48 to 0.98 (Cohen&#x2019;s &#x03BA;), and internal consistency ranges from 0.71 to 0.94 (<xref ref-type="bibr" rid="B51">51</xref>). At baseline, the diagnosis of antisocial PD was assigned only if study participants were over 18 years old. Due to participants&#x2019; young age, most of them could not be given the diagnosis. To anticipate later analyses of the stability of antisocial PD, the criteria for antisocial PD were nevertheless collected for participants both under and over 18 years old. The present analyses therefore include antisocial PD diagnoses in participants who were both younger and older than 18 years old at baseline.</p>
</sec>
</sec>
<sec id="S2.SS4">
<title>Statistical Analysis</title>
<p>First, to determine the prevalence rates of PDs at baseline and at follow-up, we performed descriptive statistical analyses. Group comparisons regarding social benefits between participants with and without a PD were assessed at follow-up using &#x03C7;<sup>2</sup> tests. Second, categorical mean-level stability was measured by the proportion of enduring cases from baseline (t1) to follow-up (t2), that is, the number of participants meeting the criteria for a PD at both measurement times divided by the total number of participants with a PD at baseline. Categorical rank-order stability was calculated by Cohen&#x2019;s &#x03BA; and tetrachoric correlations (<italic>r</italic><sub><italic>tet</italic></sub>). Cohen&#x2019;s &#x03BA; is one of the most commonly used statistics to test diagnostic agreement between diagnoses assigned at baseline and at follow-up. A negative value indicates an agreement worse than expected or even a disagreement. A value between 0 and 0.20 represents a low agreement, and a value ranging from 0.21 to 0.40 a fair agreement. A &#x03BA; between 0.41 and 0.60 indicates a moderate agreement, a &#x03BA; between 0.61 and 0.80 a substantial agreement, and 0.81&#x2013;1.0 a perfect agreement between two assessments (<xref ref-type="bibr" rid="B52">52</xref>). While Cohen&#x2019;s &#x03BA; takes into account the possibility of an agreement occurring by chance, tetrachoric correlation coefficient (<italic>r</italic><sub><italic>tet</italic></sub>) measures the mere relationship between binary baseline and follow-up scores with the assumption of bivariate normality (<xref ref-type="bibr" rid="B53">53</xref>). Similar to Pearson&#x2019;s <italic>r</italic>, a value between 0.1 and 0.3 is considered to be low, a value between 0.3 and 0.5 moderate, and a value between 0.5 and 0.8 high. Finally, for dimensional PD ratings, mean-level stability was measured by calculating mean trait scores and standard deviation at baseline and at follow-up, resulting in a mean-difference score. Cohen&#x2019;s <italic>d</italic> was used to estimate the effect size of the magnitude of change between baseline and follow-up scores. According to Cohen (<xref ref-type="bibr" rid="B54">54</xref>), an effect size of 0.20 is considered a small effect, an effect size of 0.50 a moderate effect, and an effect size of 0.80 a large effect. Dimensional rank-order stability was measured using Spearman&#x2019;s &#x03C1; (<italic>r</italic><sub><italic>s</italic></sub>), given a substantial positive skew. The interpretation of Spearman&#x2019;s &#x03C1; (<italic>r</italic><sub><italic>s</italic></sub>) is similar to that of Pearson&#x2019;s <italic>r</italic>. Additional explorative sensitivity analyses regarding the prevalence as well categorical and dimensional mean-level and rank-order stability of PD according to specific age ranges at baseline (12&#x2013;14 and 15&#x2013;18 years) are presented in the <xref ref-type="supplementary-material" rid="DS1">Supplementary Material</xref>. All statistical analyses were conducted using RStudio [Version 1.4.1106; (<xref ref-type="bibr" rid="B55">55</xref>)]. Statistical significance was set to <italic>p</italic> &#x003C; 0.05 for all analyses. Complete case analyses were performed.</p>
</sec>
</sec>
<sec id="S3" sec-type="results">
<title>Results</title>
<sec id="S3.SS1">
<title>Prevalence Rates of Current Mental Disorders at Baseline and at Follow-Up</title>
<p>Findings regarding the prevalence rates of mental disorders at baseline and at follow-up are presented in <xref ref-type="table" rid="T1">Table 1</xref>. At baseline, 74 (64.9%) participants reported a current mental-health disorder; conduct disorders (29.8%), anxiety disorders (25.4%), and PDs (20.0%) were the most frequent diagnoses. Fifty-five (61.1%) participants were receiving mental-health treatment at the time of the assessment. At follow-up, the prevalence rate for any mental disorder was about 55.6%; substance-use disorders (35.6%), PDs (30.4%), and ADHD (20.9%) were the most common. A total of 27 (23.5%) participants reported receiving mental-health treatment at follow-up (<xref ref-type="table" rid="T1">Table 1</xref>). Participants with a PD at follow-up were significantly more likely to report disability insurance than participants without a PD at follow-up [&#x03C7;<sup>2</sup>(1) = 6.10; <italic>p</italic> = 0.010] (<xref ref-type="table" rid="T2">Table 2</xref>) [see (<xref ref-type="bibr" rid="B56">56</xref>)].</p>
<table-wrap position="float" id="T2">
<label>TABLE 2</label>
<caption><p>Social benefits at follow-up (t2) (<italic>N</italic> = 115).</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="center" colspan="5">Follow-up (t2)<hr/></td>
</tr>
<tr>
<td/>
<td valign="top" align="center">Total sample</td>
<td valign="top" align="center">No PDs</td>
<td valign="top" align="center">PDs</td>
<td valign="top" align="center">&#x03C7; <sup>2</sup></td>
<td valign="top" align="center"><italic>p</italic>-value</td>
</tr>
<tr>
<td valign="top" align="center"></td>
<td valign="top" align="center" colspan="3"><hr/></td>
<td valign="top" align="center" colspan="2"><hr/></td>
</tr>
<tr>
<td/>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td/>
<td/>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Social welfare<xref ref-type="table-fn" rid="t2fns1"><sup>a</sup></xref></td>
<td valign="top" align="center">29 (25.2)</td>
<td valign="top" align="center">18 (22.5)</td>
<td valign="top" align="center">11 (31.4)</td>
<td valign="top" align="center">0.610</td>
<td valign="top" align="center">0.354</td>
</tr>
<tr>
<td valign="top" align="left">Unemployment insurance<xref ref-type="table-fn" rid="t2fns1"><sup>a</sup></xref></td>
<td valign="top" align="center">8 (7.0)</td>
<td valign="top" align="center">5 (6.2)</td>
<td valign="top" align="center">3 (8.6)</td>
<td valign="top" align="center">0.003</td>
<td valign="top" align="center">0.698</td>
</tr>
<tr>
<td valign="top" align="left">Disability insurance<xref ref-type="table-fn" rid="t2fns1"><sup>a</sup></xref></td>
<td valign="top" align="center">17 (14.8)</td>
<td valign="top" align="center">7 (8.8)</td>
<td valign="top" align="center">10 (28.6)</td>
<td valign="top" align="center">6.102</td>
<td valign="top" align="center">0.010<xref ref-type="table-fn" rid="t2fns1">&#x002A;</xref></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t2fns1"><p><italic><sup>a</sup>Only available at follow-up. &#x002A;p &#x003C; 0.05.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="S3.SS2">
<title>Prevalence Rates of PDs at Baseline and at Follow-Up</title>
<p>Findings regarding the prevalence rates of PDs at baseline and at follow-up are presented in <xref ref-type="table" rid="T3">Table 3</xref>. At baseline, 23 (20.0%) participants met the criteria for any PD. While 10 (8.7%) participants met the criteria for one PD diagnosis, 5 (4.3%) met the criteria for two, and 8 (7.0%) met the criteria for three or more PD diagnoses. With a prevalence rate of 8.7%, borderline PD was the most common diagnosis, followed by antisocial PD (6.1%). Every participant with a PD at baseline also met criteria for another type of mental disorder at baseline. At follow-up, the prevalence rate for any PD was 30.4%. Overall, 18 (15.6%) participants met the criteria for only one PD, while 8 (7.0%) had two PD diagnoses, and 9 (7.8%) met the criteria for three or more PD diagnoses. The most frequently diagnosed disorders were antisocial (16.5%), borderline (7.8%), and obsessive-compulsive PDs (7.0%). At the cluster level, cluster B PD disorders were the most prevalent diagnoses, both at baseline (13.9%) and at follow-up (20.0%). All participants with a PD at follow-up, except one, met the criteria for another type of mental disorder.</p>
<table-wrap position="float" id="T3">
<label>TABLE 3</label>
<caption><p>Prevalence rates of personality disorder diagnoses at baseline (t1) and follow-up (t2) (<italic>N</italic> = 115).</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left">Personality disorders (PDs)</td>
<td valign="top" align="center">Baseline (t1)</td>
<td valign="top" align="center">Follow-up (t2)</td>
</tr>
<tr>
<td valign="top" align="center"></td>
<td valign="top" align="center" colspan="2"><hr/></td>
</tr>
<tr>
<td/>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Any PD</td>
<td valign="top" align="center">23 (20.0)</td>
<td valign="top" align="center">35 (30.4)</td>
</tr>
<tr>
<td valign="top" align="left">One PD</td>
<td valign="top" align="center">10 (8.7)</td>
<td valign="top" align="center">18 (15.6)</td>
</tr>
<tr>
<td valign="top" align="left">Two PDs</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">8 (7.0)</td>
</tr>
<tr>
<td valign="top" align="left">&#x2265;Three PDs</td>
<td valign="top" align="center">8 (7.0)</td>
<td valign="top" align="center">9 (7.8)</td>
</tr>
<tr>
<td valign="top" align="left">Cluster A</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">8 (7.0)</td>
</tr>
<tr>
<td valign="top" align="left">Paranoid</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">3 (2.6)</td>
</tr>
<tr>
<td valign="top" align="left">Schizotypal</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">2 (1.8)</td>
</tr>
<tr>
<td valign="top" align="left">Schizoid</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">5 (4.3)</td>
</tr>
<tr>
<td valign="top" align="left">Cluster B</td>
<td valign="top" align="center">16 (13.9)</td>
<td valign="top" align="center">23 (20.0)</td>
</tr>
<tr>
<td valign="top" align="left">Histrionic</td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">0 (0.0)</td>
</tr>
<tr>
<td valign="top" align="left">Narcissistic</td>
<td valign="top" align="center">4 (3.5)</td>
<td valign="top" align="center">2 (1.7)</td>
</tr>
<tr>
<td valign="top" align="left">Borderline</td>
<td valign="top" align="center">10 (8.7)</td>
<td valign="top" align="center">9 (7.8)</td>
</tr>
<tr>
<td valign="top" align="left">Antisocial<xref ref-type="table-fn" rid="t3fna"><sup>a</sup></xref></td>
<td valign="top" align="center">7 (6.1)</td>
<td valign="top" align="center">19 (16.5)</td>
</tr>
<tr>
<td valign="top" align="left">Cluster C</td>
<td valign="top" align="center">8 (7.0)</td>
<td valign="top" align="center">13 (11.3)</td>
</tr>
<tr>
<td valign="top" align="left">Avoidant</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">5 (4.3)</td>
</tr>
<tr>
<td valign="top" align="left">Dependent</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">1 (0.9)</td>
</tr>
<tr>
<td valign="top" align="left">Obsessive compulsive</td>
<td valign="top" align="center">4 (3.5)</td>
<td valign="top" align="center">8 (7.0)</td>
</tr>
<tr>
<td valign="top" align="left">PD NOS<xref ref-type="table-fn" rid="t3fna"><sup>b</sup></xref></td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">5 (4.3)</td>
</tr>
<tr>
<td valign="top" align="left">Passive aggressive</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">5 (4.3)</td>
</tr>
<tr>
<td valign="top" align="left">Depressive</td>
<td valign="top" align="center">4 (3.5)</td>
<td valign="top" align="center">7 (6.1)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t3fna"><p><italic>Participants with multiple PDs are displayed more than once. <sup>a</sup>Including participants younger than 18 years at baseline. <sup>b</sup>PD not otherwise specified (NOS).</italic></p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="S3.SS3">
<title>Categorical Stability</title>
<p>Findings regarding the categorical stability of PDs from baseline to follow-up are presented in <xref ref-type="table" rid="T4">Table 4</xref>.</p>
<table-wrap position="float" id="T4">
<label>TABLE 4</label>
<caption><p>Categorical stability of personality disorders from baseline (t1) to follow-up (t2) (<italic>N</italic> = 115).</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center">Mean-level stability</td>
<td valign="top" align="center" colspan="2">Rank-order stability</td>
</tr>
<tr>
<td valign="top" align="center" colspan="5"></td>
<td valign="top" align="center" colspan="3"><hr/></td>
</tr>
<tr>
<td valign="top" align="left">Personality disorders (PDs)</td>
<td valign="top" align="center">Absent t1 and t2</td>
<td valign="top" align="center">Present t1/absent t2</td>
<td valign="top" align="center">Absent t1/present t2 (new cases)</td>
<td valign="top" align="center">Present t1 and t2 (enduring cases)</td>
<td valign="top" align="center">Proportion<break/> enduring<xref ref-type="table-fn" rid="t4fns1"><sup>a</sup></xref></td>
<td valign="top" align="center">Cohen&#x2019;s &#x03BA;</td>
<td valign="top" align="center">Tetrachoric correlation coefficient</td>
</tr>
<tr>
<td valign="top" align="center" colspan="8"><hr/></td>
</tr>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center"><italic>n</italic> (%)</td>
<td valign="top" align="center">%</td>
<td valign="top" align="center">&#x03BA;</td>
<td valign="top" align="center"><italic>r</italic><sub><italic>tet</italic></sub></td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Any full-syndrome PD</td>
<td valign="top" align="center">68 (59.1)</td>
<td valign="top" align="center">12 (10.4)</td>
<td valign="top" align="center">24 (20.9)</td>
<td valign="top" align="center">11 (9.6)</td>
<td valign="top" align="center">47.8</td>
<td valign="top" align="center">0.18</td>
<td valign="top" align="center">0.33<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Cluster A</td>
<td valign="top" align="center">104 (90.4)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">6 (5.2)</td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">40.0</td>
<td valign="top" align="center">0.27</td>
<td valign="top" align="center">0.60<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Paranoid</td>
<td valign="top" align="center">109 (94.9)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;0.03</td>
<td valign="top" align="center">0.38<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Schizotypal</td>
<td valign="top" align="center">113 (983)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">&#x2212;</td>
<td valign="top" align="center">&#x2212;</td>
<td valign="top" align="center">&#x2212;</td>
</tr>
<tr>
<td valign="top" align="left">Schizoid</td>
<td valign="top" align="center">109 (94.8)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">66.7</td>
<td valign="top" align="center">0.48</td>
<td valign="top" align="center">0.85<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Cluster B</td>
<td valign="top" align="center">81 (70.4)</td>
<td valign="top" align="center">11 (9.6)</td>
<td valign="top" align="center">18 (15.6)</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">31.2</td>
<td valign="top" align="center">0.11</td>
<td valign="top" align="center">0.23<xref ref-type="table-fn" rid="t4fns1">&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Histrionic</td>
<td valign="top" align="center">113 (98.3)</td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;</td>
<td valign="top" align="center">&#x2212;</td>
</tr>
<tr>
<td valign="top" align="left">Narcissistic</td>
<td valign="top" align="center">109 (94.8)</td>
<td valign="top" align="center">4 (3.5)</td>
<td valign="top" align="center">2 (1.7)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;0.02</td>
<td valign="top" align="center">0.40<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Borderline</td>
<td valign="top" align="center">97 (84.4)</td>
<td valign="top" align="center">9 (7.8)</td>
<td valign="top" align="center">8 (7.0)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">10.0</td>
<td valign="top" align="center">0.02</td>
<td valign="top" align="center">0.08</td>
</tr>
<tr>
<td valign="top" align="left">Antisocial<xref ref-type="table-fn" rid="t4fns1"><sup>b</sup></xref></td>
<td valign="top" align="center">92 (80.0)</td>
<td valign="top" align="center">4 (3.5)</td>
<td valign="top" align="center">16 (13.9)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">42.9</td>
<td valign="top" align="center">0.16</td>
<td valign="top" align="center">0.41<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Cluster C</td>
<td valign="top" align="center">95 (82.6)</td>
<td valign="top" align="center">7 (6.0)</td>
<td valign="top" align="center">12 (10.4)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">12.5</td>
<td valign="top" align="center">0.01</td>
<td valign="top" align="center">0.03</td>
</tr>
<tr>
<td valign="top" align="left">Avoidant</td>
<td valign="top" align="center">107 (93.0)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;0.03</td>
<td valign="top" align="center">0.28<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Dependent</td>
<td valign="top" align="center">113 (98.3)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;0.01</td>
<td valign="top" align="center">0.72<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Obsessive compulsive</td>
<td valign="top" align="center">104 (90.4)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">7 (6.0)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">25.0</td>
<td valign="top" align="center">0.13</td>
<td valign="top" align="center">0.38<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">PD NOS<xref ref-type="table-fn" rid="t4fns1"><sup>c</sup></xref></td>
<td valign="top" align="center">107 (93.0)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;0.03</td>
<td valign="top" align="center">0.28<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Passive aggressive</td>
<td valign="top" align="center">105 (91.3)</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">5 (4.3)</td>
<td valign="top" align="center">0 (0.0)</td>
<td valign="top" align="center">0.0</td>
<td valign="top" align="center">&#x2212;0.04</td>
<td valign="top" align="center">0.17</td>
</tr>
<tr>
<td valign="top" align="left">Depressive</td>
<td valign="top" align="center">105 (91.3)</td>
<td valign="top" align="center">3 (2.6)</td>
<td valign="top" align="center">6 (5.2)</td>
<td valign="top" align="center">1 (0.9)</td>
<td valign="top" align="center">25.0</td>
<td valign="top" align="center">0.14</td>
<td valign="top" align="center">0.42<xref ref-type="table-fn" rid="t4fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t4fns1"><p><italic><sup>a</sup>Calculated by the number of enduring cases divided by the total number of participants meeting a PD at baseline. <sup>b</sup>Including participants younger than 18 years at baseline. <sup>c</sup>PD not otherwise specified (NOS). &#x2013; measures not available, as either baseline or follow-up PD criteria were not met. &#x002A;p &#x003C; 0.05, &#x002A;&#x002A;p &#x003C; 0.01, &#x002A;&#x002A;&#x002A;p &#x003C; 0.001. The sample size is sufficient to achieve a power &#x2265;0.8 if r<sub>tet</sub> &#x2265; 0.42.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<sec id="S3.SS3.SSS1">
<title>Mean-Level Stability</title>
<p>The number of enduring cases from baseline to follow-up could only be calculated for PDs diagnosed at baseline. Since no participants met the criteria for a schizotypal PD at baseline, mean-level stability could not be calculated for this disorder. Of the 23 participants who met the criteria for one or more PDs at baseline, 11 still met the criteria for a PD diagnosis at follow-up, resulting in a categorical mean-level stability of 47.8%. Overall, 12 of these 23 participants improved from baseline to follow-up by no longer meeting the criteria for a PD, while 24 of 92 participants with no PD at baseline met the criteria for a PD at follow-up. With only one participant out of 10 meeting the criteria for borderline PD at both assessments, the categorical mean-level stability of borderline PD was low (10.0%). For schizotypal, histrionic, narcissistic, antisocial, avoidant, dependent, PD NOS, and passive-aggressive PDs, none of the participants met the criteria at baseline or at follow-up.</p>
</sec>
<sec id="S3.SS3.SSS2">
<title>Rank-Order Stability</title>
<p>Cohen&#x2019;s &#x03BA; and tetrachoric correlations (<italic>r</italic><sub><italic>tet</italic></sub>) could only be calculated for PDs for which there were participants who met the criteria at baseline or at follow-up or at both measurement points. Since no participants met the criteria for a schizotypal PD at baseline, and no participants met the criteria for a histrionic PD at follow-up, Cohen&#x2019;s &#x03BA; and tetrachoric correlations (<italic>r</italic><sub><italic>tet</italic></sub>) could not be calculated for either of these disorders. With a Cohen&#x2019;s &#x03BA; of 0.18 for any PD, the concordance between baseline and follow-up assessments was low. For individual diagnoses, &#x03BA; was likewise low, except for schizoid PD (&#x03BA; = 0.48). The tetrachoric correlation coefficient (<italic>r</italic><sub><italic>tet</italic></sub>) from baseline to follow-up for any PD was 0.33, which indicates a moderate rank-order stability. For individual PDs, rank-order stability ranged from low (borderline, avoidant, PD NOS, and passive-aggressive PDs) to moderate (paranoid, narcissistic, antisocial, obsessive-compulsive, and depressive PDs) to high (schizoid, dependent PDs). With a tetrachoric correlation coefficient (<italic>r</italic><sub><italic>tet</italic></sub>) of 0.60, rank-order stability was by far the highest for cluster A disorders.</p>
</sec>
</sec>
<sec id="S3.SS4">
<title>Dimensional Stability</title>
<p>Findings regarding the dimensional stability of PDs from baseline to follow-up are presented in <xref ref-type="table" rid="T5">Table 5</xref>.</p>
<table-wrap position="float" id="T5">
<label>TABLE 5</label>
<caption><p>Dimensional stability of personality disorders from baseline to follow-up (<italic>N</italic> = 115).</p></caption>
<table cellspacing="5" cellpadding="5" frame="hsides" rules="groups">
<thead>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="center" colspan="5">Mean-level stability<hr/></td>
<td valign="top" align="center">Rank-order stability</td>
</tr>
<tr>
<td/>
<td valign="top" align="center">Baseline</td>
<td valign="top" align="center">Follow-up</td>
<td/>
<td/>
<td/>
<td/>
</tr>
<tr>
<td valign="top" align="left"></td>
<td valign="top" align="center" colspan="2"><hr/></td>
<td valign="top" align="center" colspan="4"></td>
</tr>
<tr>
<td valign="top" align="left">Personality disorder traits</td>
<td valign="top" align="center"><italic>M</italic> (<italic>SD</italic>)</td>
<td valign="top" align="center"><italic>M</italic> (<italic>SD</italic>)</td>
<td valign="top" align="center">Mean difference</td>
<td valign="top" align="center">Cohen&#x2019;s <italic>d</italic></td>
<td valign="top" align="center"><italic>p-</italic>value</td>
<td valign="top" align="center">Spearman&#x2019;s &#x03C1;</td>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Total score</td>
<td valign="top" align="center">99.27 (19.63)</td>
<td valign="top" align="center">104.1 (18.52)</td>
<td valign="top" align="center">4.89</td>
<td valign="top" align="center">0.23</td>
<td valign="top" align="center">0.016<xref ref-type="table-fn" rid="t5fns1">&#x002A;</xref></td>
<td valign="top" align="center">0.24<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Cluster A</td>
<td valign="top" align="center">29.1 (6.94)</td>
<td valign="top" align="center">31.23 (6.96)</td>
<td valign="top" align="center">2.13</td>
<td valign="top" align="center">0.26</td>
<td valign="top" align="center">0.006<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
<td valign="top" align="center">0.18</td>
</tr>
<tr>
<td valign="top" align="left">Paranoid</td>
<td valign="top" align="center">9.08 (2.83)</td>
<td valign="top" align="center">9.90 (2.90)</td>
<td valign="top" align="center">0.82</td>
<td valign="top" align="center">0.22</td>
<td valign="top" align="center">0.017<xref ref-type="table-fn" rid="t5fns1">&#x002A;</xref></td>
<td valign="top" align="center">0.13</td>
</tr>
<tr>
<td valign="top" align="left">Schizotypal</td>
<td valign="top" align="center">10.20 (1.93)</td>
<td valign="top" align="center">10.65 (2.16)</td>
<td valign="top" align="center">0.44</td>
<td valign="top" align="center">0.14</td>
<td valign="top" align="center">0.123</td>
<td valign="top" align="center">0.11</td>
</tr>
<tr>
<td valign="top" align="left">Schizoid</td>
<td valign="top" align="center">8.19 (1.92)</td>
<td valign="top" align="center">9.36 (2.95)</td>
<td valign="top" align="center">1.17</td>
<td valign="top" align="center">0.36</td>
<td valign="top" align="center">&#x003C;0.001<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;&#x002A;</xref></td>
<td valign="top" align="center">0.22<xref ref-type="table-fn" rid="t5fns1">&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Cluster B</td>
<td valign="top" align="center">42.70 (10.11)</td>
<td valign="top" align="center">43.44 (8.93)</td>
<td valign="top" align="center">0.74</td>
<td valign="top" align="center">0.07</td>
<td valign="top" align="center">0.462</td>
<td valign="top" align="center">0.28<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Histrionic</td>
<td valign="top" align="center">9.79 (2.56)</td>
<td valign="top" align="center">9.20 (1.51)</td>
<td valign="top" align="center">-0.69</td>
<td valign="top" align="center">0.24</td>
<td valign="top" align="center">0.010<xref ref-type="table-fn" rid="t5fns1">&#x002A;</xref></td>
<td valign="top" align="center">0.28<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Narcissistic</td>
<td valign="top" align="center">10.82 (2.78)</td>
<td valign="top" align="center">10.66 (2.41)</td>
<td valign="top" align="center">-0.15</td>
<td valign="top" align="center">0.04</td>
<td valign="top" align="center">0.649</td>
<td valign="top" align="center">0.23<xref ref-type="table-fn" rid="t5fns1">&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Borderline</td>
<td valign="top" align="center">13.36 (5.05)</td>
<td valign="top" align="center">12.83 (3.92)</td>
<td valign="top" align="center">-0.53</td>
<td valign="top" align="center">0.11</td>
<td valign="top" align="center">0.236</td>
<td valign="top" align="center">0.36<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Antisocial</td>
<td valign="top" align="center">8.73 (2.56)</td>
<td valign="top" align="center">10.81 (3.70)</td>
<td valign="top" align="center">2.06</td>
<td valign="top" align="center">0.57</td>
<td valign="top" align="center">&#x003C;0.001<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;&#x002A;</xref></td>
<td valign="top" align="center">0.31<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Cluster C</td>
<td valign="top" align="center">27.47 (5.80)</td>
<td valign="top" align="center">29.73 (6.34)</td>
<td valign="top" align="center">2.26</td>
<td valign="top" align="center">0.30</td>
<td valign="top" align="center">0.001<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
<td valign="top" align="center">0.20<xref ref-type="table-fn" rid="t5fns1">&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Avoidant</td>
<td valign="top" align="center">9.13 (2.89)</td>
<td valign="top" align="center">9.18 (2.69)</td>
<td valign="top" align="center">0.05</td>
<td valign="top" align="center">0.01</td>
<td valign="top" align="center">0.864</td>
<td valign="top" align="center">0.31<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Dependent</td>
<td valign="top" align="center">9.82 (2.64)</td>
<td valign="top" align="center">10.14 (2.72)</td>
<td valign="top" align="center">0.33</td>
<td valign="top" align="center">0.10</td>
<td valign="top" align="center">0.289</td>
<td valign="top" align="center">0.27<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td valign="top" align="left">Obsessive compulsive</td>
<td valign="top" align="center">10.17 (3.05)</td>
<td valign="top" align="center">11.91 (3.31)</td>
<td valign="top" align="center">1.75</td>
<td valign="top" align="center">0.42</td>
<td valign="top" align="center">&#x003C;0.001<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;&#x002A;</xref></td>
<td valign="top" align="center">&#x2212;0.08</td>
</tr>
<tr>
<td valign="top" align="left">Passive aggressive</td>
<td valign="top" align="center">9.17 (3.01)</td>
<td valign="top" align="center">9.43 (2.64)</td>
<td valign="top" align="center">0.25</td>
<td valign="top" align="center">0.06</td>
<td valign="top" align="center">0.470</td>
<td valign="top" align="center">0.08</td>
</tr>
<tr>
<td valign="top" align="left">Depressive</td>
<td valign="top" align="center">9.35 (3.14)</td>
<td valign="top" align="center">10.41 (3.73)</td>
<td valign="top" align="center">1.06</td>
<td valign="top" align="center">0.26</td>
<td valign="top" align="center">0.005<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
<td valign="top" align="center">0.25<xref ref-type="table-fn" rid="t5fns1">&#x002A;&#x002A;</xref></td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t5fns1"><p><italic>&#x002A;p &#x003C; 0.05, &#x002A;&#x002A;p &#x003C; 0.01, &#x002A;&#x002A;&#x002A;p &#x003C; 0.001. The sample size is sufficient to achieve a power of &#x2265;0.8 if d &#x2265; 0.24 and &#x03C1; &#x2265; 0.23.</italic></p></fn>
</table-wrap-foot>
</table-wrap>
<sec id="S3.SS4.SSS1">
<title>Mean-Level Stability</title>
<p>Overall, the mean-level scores of dimensional ratings increased for most disorders. The total score significantly increased from baseline to follow-up, although the effect size was small (<italic>d</italic> = 0.23; <italic>p</italic> = 0.016). Significant increases were found for paranoid (<italic>d</italic> = 0.22; <italic>p</italic> = 0.017), schizoid (<italic>d</italic> = 0.36; <italic>p</italic> &#x003C; 0.001), antisocial (<italic>d</italic> = 0.57; <italic>p</italic> = &#x003C; 0.001), obsessive-compulsive (<italic>d</italic> = 0.42; <italic>p</italic> &#x003C; 0.001), and depressive PDs (<italic>d</italic> = 0.26; <italic>p</italic> = 0.005). Findings regarding the mean-level scores for schizotypal, narcissistic, borderline, dependent, and depressive traits revealed no significant change. A significant decrease was found only for histrionic traits, although the effect size was small (<italic>d</italic> = 0.24; <italic>p</italic> = 0.010).</p>
</sec>
<sec id="S3.SS4.SSS2">
<title>Rank-Order Stability</title>
<p>The pattern of rank-order stability of the dimensional scores from baseline to follow-up ranged from low (paranoid, schizoid, schizotypal, histrionic, narcissistic, avoidant, dependent, obsessive-compulsive, passive-aggressive, and depressive) to moderate (borderline, antisocial). Correlations were significant, except for paranoid (<italic>r</italic><sub><italic>s</italic></sub> = 0.13, p = 0.153), schizotypal (<italic>r</italic><sub><italic>s</italic></sub> = 0.11, <italic>p</italic> = 0.264), obsessive-compulsive (<italic>r</italic><sub><italic>s</italic></sub> = &#x2212;0.08, <italic>p</italic> = 0.412), and passive-aggressive traits (<italic>r</italic><sub><italic>s</italic></sub> = 0.08, <italic>p</italic> = 0.423).</p>
</sec>
</sec>
</sec>
<sec id="S4" sec-type="discussion">
<title>Discussion</title>
<p>The aim of the current study was to examine the prevalence rates as well as the mean-level and rank-order stability of PDs over a 10-year follow-up in adolescents placed in residential care and juvenile-justice institutions. Both the stability of PD categories and the stability of dimensional PD traits were analyzed from adolescence to adulthood. The present findings indicated high PD prevalence rates in young adults with a history of child welfare and juvenile-justice placements, while PD diagnoses and PD traits exhibited only low to moderate stability over the 10-year follow-up.</p>
<p>At least three findings have to be discussed in more detail. First, PD prevalence rates substantially increased from adolescence to adulthood in this high-risk sample. While the normative course of BPD during adolescence is described as an increase of BPD pathology from puberty to young adulthood (<xref ref-type="bibr" rid="B57">57</xref>), most previous findings indicate a general decline in PDs and PD traits beginning in young adulthood (<xref ref-type="bibr" rid="B17">17</xref>). On the other hand, the prevalence rates of any PD as well as of specific PDs are consistent with the existing literature; the prevalence rates of PDs in institutionalized youth and young adults with a history of out-of-home care have been found to range between 18 and 40% across studies (<xref ref-type="bibr" rid="B43">43</xref>&#x2013;<xref ref-type="bibr" rid="B45">45</xref>). A recent meta-analysis on mental disorders in incarcerated youth, which included 30 studies of 8,000 participants, indicated that antisocial and borderline PDs were relatively common in both males and females, while the prevalence of narcissistic and schizotypal PDs was comparably low (<xref ref-type="bibr" rid="B58">58</xref>). The current study seems to confirm this pattern, as antisocial and borderline PDs were among the most frequently diagnosed disorders, both at baseline and at follow-up. An increase in PD diagnoses from adolescence to adulthood in this sample, may, thus, be explained by the fact that many adolescents in residential care and juvenile-justice institutions have experienced severe childhood adversities (e.g., child abuse and neglect), which are shown to significantly contribute to the development of PDs (<xref ref-type="bibr" rid="B59">59</xref>, <xref ref-type="bibr" rid="B60">60</xref>). For instance, the meta-analysis by Porter et al. (<xref ref-type="bibr" rid="B37">37</xref>) found that patients with borderline PD were over 13 times more likely to report childhood adversity than non-clinical controls. In addition, participants in this high-risk sample were likely to have experienced a range of other critical risk factors, such as unfavorable parenting practices, low socioeconomic status, childhood psychopathology, including high substance use, self-harming behavior, and youth delinquency, which have also been shown to be significantly associated with the development of PDs over time (<xref ref-type="bibr" rid="B38">38</xref>&#x2013;<xref ref-type="bibr" rid="B42">42</xref>). Given the multifaceted nature of problems faced by juveniles in child welfare care and juvenile-justice institutions, the institutions often lack the professional and financial means to detect personality problems at an early stage, leading to delays in diagnoses and appropriate treatment. Delaying appropriate diagnoses, in turn, carries clinical risk, as evidence is accumulating that many of the harms associated with PDs occur early in the course of the disorder (<xref ref-type="bibr" rid="B61">61</xref>), and delay tends to lead toward greater impairments and poorer outcomes (<xref ref-type="bibr" rid="B62">62</xref>).</p>
<p>Second, on the categorical level, the mean-level stability of any PD was only moderate, and the mean-level stabilities of specific PDs were low to moderate, except for schizoid PD (high). The concordance between baseline and follow-up assessments (i.e., Cohen&#x2019;s &#x03BA;) was low, both for any PD and for individual PDs, except for schizoid PD (moderate). The rank-order stability (i.e., tetrachoric correlation (<italic>r</italic><sub><italic>tet</italic></sub>) of any PD category was moderate. For individual diagnoses, the rank-order stability ranged from low (i.e., borderline, avoidant, PD NOS, passive-aggressive PDs) to moderate (i.e., paranoid, narcissistic, antisocial, obsessive-compulsive, depressive PDs) to high (schizoid, dependent PDs). Regarding categorical mean-level stability, Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>) found a higher proportion of enduring cases (74%) compared to our findings (47%), which may be due to the shorter follow-up interval (2 years), the clinical status of participants (outpatients), and the narrower age range (15&#x2013;18 years old) in their study. Indeed, the explorative age-sensitive analyses in the <xref ref-type="supplementary-material" rid="DS1">Supplementary Material</xref> revealed a higher categorical mean-level stability for the participants who were 15&#x2013;18 years old than for the participants who were 12&#x2013;14 years old, although the stability still seems to be lower than that found by Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>). Categorical mean-level stabilities for individual PDs, however, were similar to those found by Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>). As such, participants may have changed specific PDs (from one PD category to another category) but did not discard the general diagnosis of a PD over time. Noteworthy, however, is that 24 (20.9%) participants first developed a PD in young adulthood. As the explorative age-sensitive analyses revealed, older adolescents (15&#x2013;18 years) were more likely to meet a PD diagnosis first at follow-up than younger adolescents (12&#x2013;14 years). This suggests that the onset of a PD indeed lies in later adolescence and that some of the present sample had not yet passed the critical age. Another explanation might be that PDs in (young) adolescence are more difficult to detect (<xref ref-type="bibr" rid="B63">63</xref>). In addition, older adolescents with a PD diagnosis between 15 and 18 years may have already had longer and more stable patterns of personality pathology, which, therefore, may be more predictive of unfavorable long-term outcomes. Nevertheless, a total of 12 (10.4%) participants improved from baseline to follow-up and no longer met the criteria for a PD in adulthood. While this could have been due to several factors (e.g., treatment or spontaneous remission), it is also possible that these participants no longer met the diagnosis of a PD but still exhibited PD symptoms. This, in turn, is a major concern of the categorical classification system, as it is based on an arbitrary diagnostic threshold that can be easily met (PD diagnosis) or not met (no PD diagnosis) by an increase or decrease in a single criterion.</p>
<p>Regarding categorical rank-order stability, the poor concordances between the baseline and follow-up assessments (i.e., Cohen&#x2019;s &#x03BA;) for any PD and for individual PD diagnoses are consistent with those found by Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>). Findings regarding rank-order stability measured with tetrachoric correlations (<italic>r</italic><sub><italic>tet</italic></sub>) are difficult to compare across studies, since Cohen&#x2019;s &#x03BA; remains the most common statistical measure for assessing the rank-order stability of categorical data. Overall, rank-order stability nevertheless seemed to be higher for specific PD diagnoses (i.e., paranoid, narcissistic, avoidant, dependent, PD NOS, and passive-aggressive PDs) than mean-level stability for these PD diagnoses, which suggests that even if the specific diagnoses did not remain the same over time, the rank ordering of participants with such a disorder appeared to be more or less the same. Both the rank-order stability and the mean-level stability of borderline PD were particularly weak, which indicates that on average, neither the category nor the rank ordering of participants with a borderline PD remained the same over time. While this may seem somewhat surprising, it is consistent with the narrative review from Bondurant et al. (<xref ref-type="bibr" rid="B64">64</xref>), which suggests that there is only little diagnostic borderline PD stability in adolescence. Interestingly, both Cohen&#x2019;s &#x03BA; and tetrachoric correlation coefficients (<italic>r</italic><sub><italic>tet</italic></sub>) were considerably higher for older adolescents at baseline (15&#x2013;18 years) compared to younger adolescents (12&#x2013;14 years old) at baseline (see <xref ref-type="supplementary-material" rid="DS1">Supplementary Table 2</xref>), which suggests that diagnoses in early adolescence should be treated with caution.</p>
<p>Third, on the dimensional level, PD scores significantly increased for most of the disorders, except for schizotypal, avoidant, narcissistic, borderline, dependent, and passive-aggressive traits. Histrionic traits significantly decreased from baseline to follow-up. Effect sizes were generally low, except for antisocial and obsessive-compulsive traits. In contrast to our findings, Johnson et al. (<xref ref-type="bibr" rid="B34">34</xref>) found a significant mean-level decline in dimensional ratings from adolescence to adulthood, and Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>) found neither a significant increase nor a decrease in PD traits, except for paranoid (increase), antisocial (increase), and depressive PDs (decrease). One explanation is that the study by Johnson et al. (<xref ref-type="bibr" rid="B34">34</xref>) was conducted in a community-based sample, while the study by Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>) was conducted with older adolescent outpatients. The overall low to moderate dimensional rank-order stability in the present study was, however, consistent with the rank-order stability found in the studies by Johnson et al. (<xref ref-type="bibr" rid="B34">34</xref>) and Chanen et al. (<xref ref-type="bibr" rid="B36">36</xref>). This indicates that although mean-level PD traits tended to increase among adolescents in residential care and juvenile-justice institutions through adulthood, their individual rank ordering seemed to be less stable, emphasizing interindividual differences among participants. The additional explorative age-sensitive analyses revealed higher dimensional mean-level and rank-order stability estimates regarding older participants (15&#x2013;18 years old) than younger participants (12&#x2013;14 years old). On the one hand, this highlights the presence of PD traits in early adolescence but on the other hand, suggests that PD diagnoses before the age of 15 should be interpreted with caution.</p>
<sec id="S4.SS1">
<title>Strengths</title>
<p>The current study fills an important gap in the existing literature on the stability of PDs by explicitly presenting findings from adolescence to adulthood in a high-risk sample. Indeed, only a few studies have investigated the stability of PDs from adolescence to adulthood, and to the best of our knowledge, none have yet investigated the stability of PDs from adolescence to adulthood in adolescents in residential care and juvenile-justice institutions. Yet these adolescents have a particularly high risk of developing a PD due to a cumulation of risk factors. Considering the apparent role of developmental tasks in the transition from adolescence to adulthood in the development of PDs, this study is particularly valuable. Another strength of the current study is the long follow-up interval of 10 years. This is noteworthy given that young-adult care leavers (i.e., juveniles who left residential care or juvenile-justice institutions) are often difficult to locate, since many live in rather unstable and changing circumstances (<xref ref-type="bibr" rid="B65">65</xref>) or suffer from severe mental-health disorders (<xref ref-type="bibr" rid="B66">66</xref>).</p>
</sec>
<sec id="S4.SS2">
<title>Limitations</title>
<p>Nonetheless, the findings of this study must be interpreted under the consideration of some limitations. First, the relatively small sample size of 115 participants must be emphasized. As a result, the number of cases for categorical PDs were small, which made it difficult to adequately assess categorical stability and, therefore, the results must be interpreted with caution and replications including larger sample sizes are highly needed. Second, although no significant differences were found in the sociodemographic baseline data between included and excluded participants, a selection bias cannot be completely ruled out. Indeed, positive self-selection may occur in longitudinally followed-up high-risk samples, as participants with severe PDs may have declined to participate at follow-up or could not be located due to difficult life circumstances. On the other hand, it may be that participants who remained connected to mental health care were more likely to participate in the current follow-up study, which could explain the high prevalence rates of PDs. Third, the current study only allowed PDs to be assessed using a two-measurement-point design. The amount of change between two measurement points is, however, not fully informative about the shape of each person&#x2019;s individual growth trajectory. In addition, a two-wave design cannot distinguish true change from measurement error (<xref ref-type="bibr" rid="B67">67</xref>) and is unable to evaluate the impact of regression-to-the-mean effects; that is, a statistical artifact making naturally occurring variations look like true changes when particularly large or small scores are followed by scores closer to the mean (<xref ref-type="bibr" rid="B68">68</xref>). Fourth, the dimensional approach taken within this study does not precisely correspond to the dimensions within the ICD-11, as the latter go beyond a mere sum of features within a categorical diagnosis. However, the dimensional approach adopted in the current study can be considered as a proxy, as no empirical evidence was yet available for the dimensional approach proposed by the ICD-11 at the time of the baseline study. Finally, while the present study explicitly focused on the stability of PDs from adolescence to adulthood, the cutoff age of 18 years at baseline is somewhat arbitrary, although adulthood is traditionally described as beginning at the age of 18 years. Indeed, based on psychosocial characteristics, recent studies have suggested that emerging adulthood is a period between adolescence (18 years) and full-fledged adulthood (25 years) (<xref ref-type="bibr" rid="B69">69</xref>). Specifically, with regard to etiological influences on the development of personality traits, Hopwood et al. (<xref ref-type="bibr" rid="B70">70</xref>) defined late adolescence at age 17, emerging adulthood at age 24, and young adulthood at age 29. Future studies should consider the prolongation of adolescence or emerging adulthood, which is currently taking place, especially in Western societies (<xref ref-type="bibr" rid="B69">69</xref>), in order to adequately assess the stability of PDs from adolescence to adulthood.</p>
</sec>
</sec>
<sec id="S5" sec-type="conclusion">
<title>Conclusion</title>
<p>Three main findings can be drawn from the current study. First, the prevalence rates of PDs in young adults with a history of child welfare and juvenile-justice placements are high. Second, most categorical PD diagnoses and dimensional PD traits increased from adolescence to adulthood in our sample. Third, overall, the findings indicate low to moderate stability of PDs and PD traits from adolescence to adulthood, although the extent of stability differed according to the PD construct (i.e., categorical diagnoses or dimensional traits), the type of stability (i.e., mean-level or rank-order stability) and the specific PD and PD trait being assessed. As a result, the current findings are in accordance with the growing evidence, that PDs are not that stable. This in turn, emphasizes the current shift to a more dimensional model and highlights the use of the upcoming ICD-11 that acknowledges PDs as only &#x201C;relatively&#x201D; stable.</p>
</sec>
<sec id="S6" sec-type="data-availability">
<title>Data Availability Statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="S7">
<title>Ethics Statement</title>
<p>The studies involving humans participants were reviewed and approved by the Ethics Committees on Research Involving Humans at the University of Basel and the University of Lausanne (Switzerland) as well as the Institutional Review Board at the University of Ulm (Germany). The follow-up study procedure was approved by the Ethics Committee Northwestern and Central Switzerland. Written informed consent to participate in this study was provided by the participants and the participants&#x2019; legal guardian/next of kin, if participants were under 18 years old.</p>
</sec>
<sec id="S8">
<title>Author Contributions</title>
<p>Dd&#x2019;H, MSt, CB, and KS contributed to conceiving and designing the present manuscript. Dd&#x2019;H wrote the first draft of the manuscript and analyzed the data. Dd&#x2019;H, DB, SS, and CB collected the data. MSt supervised the data analyses. CB, MB, NJ, MSc, JF, and KS commented on an earlier draft of the article and supervised the entire process. All authors read and approved the final manuscript.</p>
</sec>
<sec id="conf1" sec-type="COI-statement">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="pudiscl1" sec-type="disclaimer">
<title>Publisher&#x2019;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</body>
<back>
<sec id="S9" sec-type="funding-information">
<title>Funding</title>
<p>This work was funded by the Swiss Federal Ministry of Justice. Dd&#x2019;H was funded by an individual Ph.D. fellowship from the Fonds National de la Recherche du Luxembourg (FNR).</p>
</sec>
<ack><p>We would like to thank the youth welfare and juvenile-justice institutions involved in the study, participants, and their assigned caseworkers. In addition, we would also like to thank the study members for recruiting and assessing participants.</p>
</ack>
<sec id="S11" sec-type="supplementary-material">
<title>Supplementary Material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fpsyt.2022.840678/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fpsyt.2022.840678/full#supplementary-material</ext-link></p>
<supplementary-material xlink:href="Data_Sheet_1.docx" id="DS1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" xmlns:xlink="http://www.w3.org/1999/xlink"/>
</sec>
<ref-list>
<title>References</title>
<ref id="B1"><label>1.</label><citation citation-type="journal"><collab>American Psychiatric Association.</collab> <source><italic>Diagnostic and Statistical Manual of Mental Disorders.</italic></source> <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>American Psychiatric Association</publisher-name> (<year>1980</year>).</citation></ref>
<ref id="B2"><label>2.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Loranger</surname> <given-names>AW</given-names></name> <name><surname>Lenzenweger</surname> <given-names>MF</given-names></name> <name><surname>Gartner</surname> <given-names>AF</given-names></name> <name><surname>Susman</surname> <given-names>VL</given-names></name> <name><surname>Herzig</surname> <given-names>J</given-names></name> <name><surname>Zammit</surname> <given-names>GK</given-names></name><etal/></person-group> <article-title>Trait-state artifacts and the diagnosis of personality-disorders.</article-title> <source><italic>Arch Gen Psychiatry.</italic></source> (<year>1991</year>) <volume>48</volume>:<fpage>720</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1001/archpsyc.1991.01810320044007</pub-id> <pub-id pub-id-type="pmid">1883255</pub-id></citation></ref>
<ref id="B3"><label>3.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Skodol</surname> <given-names>AE</given-names></name></person-group>. <article-title>Can personality disorders be redefined in personality trait terms?</article-title> <source><italic>Am Psychiatric Assoc.</italic></source> (<year>2018</year>) <volume>175</volume>:<fpage>590</fpage>&#x2013;<lpage>2</lpage>. <pub-id pub-id-type="doi">10.1176/appi.ajp.2018.18040481</pub-id> <pub-id pub-id-type="pmid">29961368</pub-id></citation></ref>
<ref id="B4"><label>4.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bornstein</surname> <given-names>RF</given-names></name> <name><surname>Natoli</surname> <given-names>AP</given-names></name></person-group>. <article-title>Clinical utility of categorical and dimensional perspectives on personality pathology: a meta-analytic review.</article-title> <source><italic>Pers Disord Theory Res Treat.</italic></source> (<year>2019</year>) <volume>10</volume>:<issue>479</issue>. <pub-id pub-id-type="doi">10.1037/per0000365</pub-id> <pub-id pub-id-type="pmid">31545632</pub-id></citation></ref>
<ref id="B5"><label>5.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zimmermann</surname> <given-names>J</given-names></name> <name><surname>Kerber</surname> <given-names>A</given-names></name> <name><surname>Rek</surname> <given-names>K</given-names></name> <name><surname>Hopwood</surname> <given-names>CJ</given-names></name> <name><surname>Krueger</surname> <given-names>RF</given-names></name></person-group>. <article-title>A brief but comprehensive review of research on the alternative DSM-5 model for personality disorders.</article-title> <source><italic>Curr Psychiatry Rep.</italic></source> (<year>2019</year>) <volume>21</volume>:<issue>92</issue>. <pub-id pub-id-type="doi">10.1007/s11920-019-1079-z</pub-id> <pub-id pub-id-type="pmid">31410586</pub-id></citation></ref>
<ref id="B6"><label>6.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Frances</surname> <given-names>A</given-names></name></person-group>. <article-title>Dimensional diagnosis of personality&#x2013;not whether, but when and which.</article-title> <source><italic>Psychol Inquiry.</italic></source> (<year>1993</year>) <volume>4</volume>:<fpage>110</fpage>&#x2013;<lpage>1</lpage>. <pub-id pub-id-type="doi">10.1207/s15327965pli0402_7</pub-id></citation></ref>
<ref id="B7"><label>7.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hopwood</surname> <given-names>CJ</given-names></name> <name><surname>Kotov</surname> <given-names>R</given-names></name> <name><surname>Krueger</surname> <given-names>RF</given-names></name> <name><surname>Watson</surname> <given-names>D</given-names></name> <name><surname>Widiger</surname> <given-names>TA</given-names></name> <name><surname>Althoff</surname> <given-names>RR</given-names></name><etal/></person-group> <article-title>The time has come for dimensional personality disorder diagnosis.</article-title> <source><italic>Pers Ment Health.</italic></source> (<year>2018</year>) <volume>12</volume>:<issue>82</issue>.</citation></ref>
<ref id="B8"><label>8.</label><citation citation-type="journal"><collab>World Health Organization.</collab> <source><italic>International Statistical Classification of Diseases and Related Health Problems.</italic></source> (<year>2018</year>). Available online at: <ext-link ext-link-type="uri" xlink:href="https://www.who.int/classifications/icd/en/">https://www.who.int/classifications/icd/en/</ext-link> (<comment>accessed March 19, 2018</comment>).</citation></ref>
<ref id="B9"><label>9.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bach</surname> <given-names>B</given-names></name> <name><surname>First</surname> <given-names>MB</given-names></name></person-group>. <article-title>Application of the ICD-11 classification of personality disorders.</article-title> <source><italic>BMC Psychiatry.</italic></source> (<year>2018</year>) <volume>18</volume>:<issue>351</issue>. <pub-id pub-id-type="doi">10.1186/s12888-018-1908-3I</pub-id></citation></ref>
<ref id="B10"><label>10.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hansen</surname> <given-names>SJ</given-names></name> <name><surname>Christensen</surname> <given-names>S</given-names></name> <name><surname>Kongerslev</surname> <given-names>MT</given-names></name> <name><surname>First</surname> <given-names>MB</given-names></name> <name><surname>Widiger</surname> <given-names>TA</given-names></name> <name><surname>Simonsen</surname> <given-names>E</given-names></name><etal/></person-group> <article-title>Mental health professionals&#x2019; perceived clinical utility of the ICD-10 vs. ICD-11 classification of personality disorders.</article-title> <source><italic>Pers Ment Health.</italic></source> (<year>2019</year>) <volume>13</volume>:<fpage>84</fpage>&#x2013;<lpage>95</lpage>. <pub-id pub-id-type="doi">10.1002/pmh.1442</pub-id> <pub-id pub-id-type="pmid">30989832</pub-id></citation></ref>
<ref id="B11"><label>11.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Birkh&#x00F6;lzer</surname> <given-names>M</given-names></name> <name><surname>Schmeck</surname> <given-names>K</given-names></name> <name><surname>Goth</surname> <given-names>K</given-names></name></person-group>. <article-title>Assessment of criterion A.</article-title> <source><italic>Curr Opin Psychol.</italic></source> (<year>2021</year>) <volume>37</volume>:<fpage>98</fpage>&#x2013;<lpage>103</lpage>.</citation></ref>
<ref id="B12"><label>12.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Grilo</surname> <given-names>C</given-names></name> <name><surname>McGlashan</surname> <given-names>T</given-names></name> <name><surname>Oldham</surname> <given-names>J</given-names></name></person-group>. <article-title>Course and stability of personality disorders.</article-title> <source><italic>J Psychiatr Pract.</italic></source> (<year>1998</year>) <volume>4</volume>:<fpage>61</fpage>&#x2013;<lpage>75</lpage>.</citation></ref>
<ref id="B13"><label>13.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zanarini</surname> <given-names>MC</given-names></name> <name><surname>Frankenburg</surname> <given-names>FR</given-names></name> <name><surname>Reich</surname> <given-names>DB</given-names></name> <name><surname>Silk</surname> <given-names>KR</given-names></name> <name><surname>Hudson</surname> <given-names>JI</given-names></name> <name><surname>McSweeney</surname> <given-names>LB</given-names></name></person-group>. <article-title>The subsyndromal phenomenology of borderline personality disorder: a 10-year follow-up study.</article-title> <source><italic>Am J Psychiatry.</italic></source> (<year>2007</year>) <volume>164</volume>:<fpage>929</fpage>&#x2013;<lpage>35</lpage>. <pub-id pub-id-type="doi">10.1176/ajp.2007.164.6.929</pub-id> <pub-id pub-id-type="pmid">17541053</pub-id></citation></ref>
<ref id="B14"><label>14.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Shea</surname> <given-names>MT</given-names></name> <name><surname>Yen</surname> <given-names>S</given-names></name></person-group>. <article-title>Stability as a distinction between axis I and axis II disorders.</article-title> <source><italic>J Pers Disord.</italic></source> (<year>2003</year>) <volume>17</volume>:<fpage>373</fpage>&#x2013;<lpage>86</lpage>. <pub-id pub-id-type="doi">10.1521/pedi.17.5.373.22973</pub-id> <pub-id pub-id-type="pmid">14632373</pub-id></citation></ref>
<ref id="B15"><label>15.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Skodol</surname> <given-names>AE</given-names></name> <name><surname>Gunderson</surname> <given-names>JG</given-names></name> <name><surname>Shea</surname> <given-names>MT</given-names></name> <name><surname>McGlashan</surname> <given-names>TH</given-names></name> <name><surname>Morey</surname> <given-names>LC</given-names></name> <name><surname>Sanislow</surname> <given-names>CA</given-names></name><etal/></person-group> <article-title>The collaborative longitudinal personality disorders study (CLPS): overview and implications.</article-title> <source><italic>J Pers Disord.</italic></source> (<year>2005</year>) <volume>19</volume>:<fpage>487</fpage>&#x2013;<lpage>504</lpage>. <pub-id pub-id-type="doi">10.1521/pedi.2005.19.5.487</pub-id> <pub-id pub-id-type="pmid">16274278</pub-id></citation></ref>
<ref id="B16"><label>16.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Shea</surname> <given-names>MT</given-names></name> <name><surname>Stout</surname> <given-names>R</given-names></name> <name><surname>Gunderson</surname> <given-names>J</given-names></name> <name><surname>Morey</surname> <given-names>LC</given-names></name> <name><surname>Grilo</surname> <given-names>CM</given-names></name> <name><surname>McGlashan</surname> <given-names>T</given-names></name><etal/></person-group> <article-title>Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders.</article-title> <source><italic>Am J Psychiatry.</italic></source> (<year>2002</year>) <volume>159</volume>:<fpage>2036</fpage>&#x2013;<lpage>41</lpage>. <pub-id pub-id-type="doi">10.1176/appi.ajp.159.12.2036</pub-id> <pub-id pub-id-type="pmid">12450953</pub-id></citation></ref>
<ref id="B17"><label>17.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gunderson</surname> <given-names>JG</given-names></name> <name><surname>Stout</surname> <given-names>RL</given-names></name> <name><surname>McGlashan</surname> <given-names>TH</given-names></name> <name><surname>Shea</surname> <given-names>MT</given-names></name> <name><surname>Morey</surname> <given-names>LC</given-names></name> <name><surname>Grilo</surname> <given-names>CM</given-names></name><etal/></person-group> <article-title>Ten-year course of borderline personality disorder: psychopathology and function from the collaborative longitudinal personality disorders study.</article-title> <source><italic>Arch Gen Psychiatry.</italic></source> (<year>2011</year>) <volume>68</volume>:<fpage>827</fpage>&#x2013;<lpage>37</lpage>. <pub-id pub-id-type="doi">10.1001/archgenpsychiatry.2011.37</pub-id> <pub-id pub-id-type="pmid">21464343</pub-id></citation></ref>
<ref id="B18"><label>18.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Morey</surname> <given-names>LC</given-names></name> <name><surname>Hopwood</surname> <given-names>CJ</given-names></name></person-group>. <article-title>Stability and change in personality disorders.</article-title> <source><italic>Annu Rev Clin Psychol.</italic></source> (<year>2013</year>) <volume>9</volume>:<fpage>499</fpage>&#x2013;<lpage>528</lpage>.</citation></ref>
<ref id="B19"><label>19.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Seifert</surname> <given-names>I</given-names></name> <name><surname>Rohrer</surname> <given-names>JM</given-names></name> <name><surname>Egloff</surname> <given-names>B</given-names></name> <name><surname>Schmukle</surname> <given-names>S.</given-names></name></person-group> <article-title>The development of the rank-order stability of the big five across the life span.</article-title> <source><italic>PsyArXiv</italic></source> [<comment>Preprint</comment>]. (<year>2021</year>): <pub-id pub-id-type="doi">10.31234/osf.io/vdrjs</pub-id></citation></ref>
<ref id="B20"><label>20.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Durbin</surname> <given-names>CE</given-names></name> <name><surname>Klein</surname> <given-names>DN</given-names></name></person-group>. <article-title>Ten-year stability of personality disorders among outpatients with mood disorders.</article-title> <source><italic>J Abnorm Psychol.</italic></source> (<year>2006</year>) <volume>115</volume>:<fpage>75</fpage>&#x2013;<lpage>84</lpage>. <pub-id pub-id-type="doi">10.1037/0021-843X.115.1.75</pub-id> <pub-id pub-id-type="pmid">16492098</pub-id></citation></ref>
<ref id="B21"><label>21.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Grilo</surname> <given-names>CM</given-names></name> <name><surname>McGlashan</surname> <given-names>TH</given-names></name></person-group>. <article-title>Stability and course of personality disorders.</article-title> <source><italic>Curr Opin Psychiatry.</italic></source> (<year>1999</year>) <volume>12</volume>:<fpage>157</fpage>&#x2013;<lpage>62</lpage>. <pub-id pub-id-type="doi">10.1097/00001504-199903000-00003</pub-id></citation></ref>
<ref id="B22"><label>22.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Samuel</surname> <given-names>DB</given-names></name> <name><surname>Hopwood</surname> <given-names>CJ</given-names></name> <name><surname>Ansell</surname> <given-names>EB</given-names></name> <name><surname>Morey</surname> <given-names>LC</given-names></name> <name><surname>Sanislow</surname> <given-names>CA</given-names></name> <name><surname>Markowitz</surname> <given-names>JC</given-names></name><etal/></person-group> <article-title>Comparing the temporal stability of self-report and interview assessed personality disorder.</article-title> <source><italic>J Abnorm Psychol.</italic></source> (<year>2011</year>) <volume>120</volume>:<fpage>670</fpage>&#x2013;<lpage>80</lpage>. <pub-id pub-id-type="doi">10.1037/a0022647</pub-id> <pub-id pub-id-type="pmid">21443287</pub-id></citation></ref>
<ref id="B23"><label>23.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Grilo</surname> <given-names>CM</given-names></name> <name><surname>Sanislow</surname> <given-names>CA</given-names></name> <name><surname>Gunderson</surname> <given-names>JG</given-names></name> <name><surname>Pagano</surname> <given-names>ME</given-names></name> <name><surname>Yen</surname> <given-names>S</given-names></name> <name><surname>Zanarini</surname> <given-names>MC</given-names></name><etal/></person-group> <article-title>Two-year stability and change of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders.</article-title> <source><italic>J Consult Clin Psychol.</italic></source> (<year>2004</year>) <volume>72</volume>:<fpage>767</fpage>&#x2013;<lpage>75</lpage>. <pub-id pub-id-type="doi">10.1037/0022-006X.72.5.767</pub-id> <pub-id pub-id-type="pmid">15482035</pub-id></citation></ref>
<ref id="B24"><label>24.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hopwood</surname> <given-names>CJ</given-names></name> <name><surname>Morey</surname> <given-names>LC</given-names></name> <name><surname>Donnellan</surname> <given-names>MB</given-names></name> <name><surname>Samuel</surname> <given-names>DB</given-names></name> <name><surname>Grilo</surname> <given-names>CM</given-names></name> <name><surname>McGlashan</surname> <given-names>TH</given-names></name><etal/></person-group> <article-title>Ten-year rank-order stability of personality traits and disorders in a clinical sample.</article-title> <source><italic>J Pers.</italic></source> (<year>2013</year>) <volume>81</volume>:<fpage>335</fpage>&#x2013;<lpage>44</lpage>. <pub-id pub-id-type="doi">10.1111/j.1467-6494.2012.00801.x</pub-id> <pub-id pub-id-type="pmid">22812532</pub-id></citation></ref>
<ref id="B25"><label>25.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chanen</surname> <given-names>AM</given-names></name> <name><surname>McCutcheon</surname> <given-names>LK</given-names></name></person-group>. <article-title>Complex case: personality disorder in adolescence: the diagnosis that dare not speak its name.</article-title> <source><italic>Pers Ment Health.</italic></source> (<year>2008</year>) <volume>2</volume>:<fpage>35</fpage>&#x2013;<lpage>41</lpage>.</citation></ref>
<ref id="B26"><label>26.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Miller</surname> <given-names>AL</given-names></name> <name><surname>Muehlenkamp</surname> <given-names>JJ</given-names></name> <name><surname>Jacobson</surname> <given-names>CM</given-names></name></person-group>. <article-title>Fact or fiction: diagnosing borderline personality disorder in adolescents.</article-title> <source><italic>Clin Psychol Rev.</italic></source> (<year>2008</year>) <volume>28</volume>:<fpage>969</fpage>&#x2013;<lpage>81</lpage>. <pub-id pub-id-type="doi">10.1016/j.cpr.2008.02.004</pub-id> <pub-id pub-id-type="pmid">18358579</pub-id></citation></ref>
<ref id="B27"><label>27.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Shiner</surname> <given-names>RL</given-names></name> <name><surname>Allen</surname> <given-names>TA</given-names></name></person-group>. <article-title>Assessing personality disorders in adolescents: seven guiding principles.</article-title> <source><italic>Clin Psychol Sci Pract.</italic></source> (<year>2013</year>) <volume>20</volume>:<issue>361</issue>. <pub-id pub-id-type="doi">10.1111/cpsp.12047</pub-id></citation></ref>
<ref id="B28"><label>28.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chanen</surname> <given-names>A</given-names></name> <name><surname>Sharp</surname> <given-names>C</given-names></name> <name><surname>Hoffman</surname> <given-names>P</given-names></name></person-group> <collab>Global Alliance for Prevention and Early Intervention for Borderline Personality Disorder.</collab> <article-title>Prevention and early intervention for borderline personality disorder: a novel public health priority.</article-title> <source><italic>World Psychiatry.</italic></source> (<year>2017</year>) <volume>16</volume>:<issue>215</issue>. <pub-id pub-id-type="doi">10.1002/wps.20429</pub-id> <pub-id pub-id-type="pmid">28498598</pub-id></citation></ref>
<ref id="B29"><label>29.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sharp</surname> <given-names>C</given-names></name> <name><surname>Wall</surname> <given-names>K</given-names></name></person-group>. <article-title>Personality pathology grows up: adolescence as a sensitive period.</article-title> <source><italic>Curr Opin Psychol.</italic></source> (<year>2018</year>) <volume>21</volume>:<fpage>111</fpage>&#x2013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1016/j.copsyc.2017.11.010</pub-id> <pub-id pub-id-type="pmid">29227834</pub-id></citation></ref>
<ref id="B30"><label>30.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Grilo</surname> <given-names>CM</given-names></name> <name><surname>Becker</surname> <given-names>DF</given-names></name> <name><surname>Edell</surname> <given-names>WS</given-names></name> <name><surname>McGlashan</surname> <given-names>TH</given-names></name></person-group>. <article-title>Stability and change of DSM-III-R personality disorder dimensions in adolescents followed up 2 years after psychiatric hospitalization.</article-title> <source><italic>Compr Psychiatry.</italic></source> (<year>2001</year>) <volume>42</volume>:<fpage>364</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1053/comp.2001.26274</pub-id> <pub-id pub-id-type="pmid">11559862</pub-id></citation></ref>
<ref id="B31"><label>31.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Havighurst</surname> <given-names>RJ.</given-names></name></person-group> <source><italic>Developmental Tasks and Education.</italic></source> <publisher-loc>Chicago</publisher-loc>: <publisher-name>University of Chicago Press</publisher-name> (<year>1948</year>).</citation></ref>
<ref id="B32"><label>32.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sharp</surname> <given-names>C</given-names></name> <name><surname>Vanwoerden</surname> <given-names>S</given-names></name> <name><surname>Wall</surname> <given-names>K</given-names></name></person-group>. <article-title>Adolescence as a sensitive period for the development of personality disorder.</article-title> <source><italic>Psychiatr Clin.</italic></source> (<year>2018</year>) <volume>41</volume>:<fpage>669</fpage>&#x2013;<lpage>83</lpage>. <pub-id pub-id-type="doi">10.1016/j.psc.2018.07.004</pub-id> <pub-id pub-id-type="pmid">30447731</pub-id></citation></ref>
<ref id="B33"><label>33.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cohen</surname> <given-names>P</given-names></name> <name><surname>Crawford</surname> <given-names>TN</given-names></name> <name><surname>Johnson</surname> <given-names>JG</given-names></name> <name><surname>Kasen</surname> <given-names>S</given-names></name></person-group>. <article-title>The children in the community study of developmental course of personality disorder.</article-title> <source><italic>J Pers Disord.</italic></source> (<year>2005</year>) <volume>19</volume>:<fpage>466</fpage>&#x2013;<lpage>86</lpage>. <pub-id pub-id-type="doi">10.1521/pedi.2005.19.5.466</pub-id> <pub-id pub-id-type="pmid">16274277</pub-id></citation></ref>
<ref id="B34"><label>34.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Johnson</surname> <given-names>JG</given-names></name> <name><surname>Cohen</surname> <given-names>P</given-names></name> <name><surname>Kasen</surname> <given-names>S</given-names></name> <name><surname>Skodol</surname> <given-names>AE</given-names></name> <name><surname>Hamagami</surname> <given-names>F</given-names></name> <name><surname>Brook</surname> <given-names>JS</given-names></name></person-group>. <article-title>Age-related change in personality disorder trait levels between early adolescence and adulthood: a community-based longitudinal investigation.</article-title> <source><italic>Acta Psychiatr Scand.</italic></source> (<year>2000</year>) <volume>102</volume>:<fpage>265</fpage>&#x2013;<lpage>75</lpage>. <pub-id pub-id-type="doi">10.1034/j.1600-0447.2000.102004265.x</pub-id> <pub-id pub-id-type="pmid">11089726</pub-id></citation></ref>
<ref id="B35"><label>35.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bornovalova</surname> <given-names>MA</given-names></name> <name><surname>Hicks</surname> <given-names>BM</given-names></name> <name><surname>Iacono</surname> <given-names>WG</given-names></name> <name><surname>McGue</surname> <given-names>M</given-names></name></person-group>. <article-title>Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study.</article-title> <source><italic>Dev Psychopathol.</italic></source> (<year>2009</year>) <volume>21</volume>:<fpage>1335</fpage>&#x2013;<lpage>53</lpage>. <pub-id pub-id-type="doi">10.1017/S0954579409990186</pub-id> <pub-id pub-id-type="pmid">19825271</pub-id></citation></ref>
<ref id="B36"><label>36.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chanen</surname> <given-names>AM</given-names></name> <name><surname>Jackson</surname> <given-names>HJ</given-names></name> <name><surname>McGorry</surname> <given-names>PD</given-names></name> <name><surname>Allot</surname> <given-names>KA</given-names></name> <name><surname>Clarkson</surname> <given-names>V</given-names></name> <name><surname>Hok</surname> <given-names>PY</given-names></name></person-group>. <article-title>Two-year stability of personality disorder in older adolescent outpatients.</article-title> <source><italic>J Pers Disord.</italic></source> (<year>2004</year>) <volume>18</volume>:<fpage>526</fpage>&#x2013;<lpage>41</lpage>. <pub-id pub-id-type="doi">10.1521/pedi.18.6.526.54798</pub-id> <pub-id pub-id-type="pmid">15615665</pub-id></citation></ref>
<ref id="B37"><label>37.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Porter</surname> <given-names>C</given-names></name> <name><surname>Palmier-Claus</surname> <given-names>J</given-names></name> <name><surname>Branitsky</surname> <given-names>A</given-names></name> <name><surname>Mansell</surname> <given-names>W</given-names></name> <name><surname>Warwick</surname> <given-names>H</given-names></name> <name><surname>Varese</surname> <given-names>F</given-names></name></person-group>. <article-title>Childhood adversity and borderline personality disorder: a meta-analysis.</article-title> <source><italic>Acta Psychiatr Scand.</italic></source> (<year>2020</year>) <volume>141</volume>:<fpage>6</fpage>&#x2013;<lpage>20</lpage>.</citation></ref>
<ref id="B38"><label>38.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cohen</surname> <given-names>P</given-names></name></person-group>. <article-title>Childhood risks for young adult symptoms of personality disorder: Method and substance.</article-title> <source><italic>Multiv Behav Res.</italic></source> (<year>1996</year>) <volume>31</volume>:<fpage>121</fpage>&#x2013;<lpage>48</lpage>. <pub-id pub-id-type="doi">10.1207/s15327906mbr3101_7</pub-id> <pub-id pub-id-type="pmid">26750712</pub-id></citation></ref>
<ref id="B39"><label>39.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bernstein</surname> <given-names>DP</given-names></name> <name><surname>Cohen</surname> <given-names>P</given-names></name> <name><surname>Skodol</surname> <given-names>A</given-names></name> <name><surname>Bezirganian</surname> <given-names>S</given-names></name> <name><surname>Brook</surname> <given-names>JS</given-names></name></person-group>. <article-title>Childhood antecedents of adolescent personality disorders.</article-title> <source><italic>Am J Psychiatry.</italic></source> (<year>1996</year>) <volume>153</volume>:<fpage>907</fpage>&#x2013;<lpage>13</lpage>. <pub-id pub-id-type="doi">10.1176/ajp.153.7.907</pub-id> <pub-id pub-id-type="pmid">8659613</pub-id></citation></ref>
<ref id="B40"><label>40.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Thatcher</surname> <given-names>DL</given-names></name> <name><surname>Cornelius</surname> <given-names>JR</given-names></name> <name><surname>Clark</surname> <given-names>DB</given-names></name></person-group>. <article-title>Adolescent alcohol use disorders predict adult borderline personality.</article-title> <source><italic>Addict Behav.</italic></source> (<year>2005</year>) <volume>30</volume>:<fpage>1709</fpage>&#x2013;<lpage>24</lpage>. <pub-id pub-id-type="doi">10.1016/j.addbeh.2005.07.008</pub-id> <pub-id pub-id-type="pmid">16095845</pub-id></citation></ref>
<ref id="B41"><label>41.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Zanarini</surname> <given-names>MC</given-names></name> <name><surname>Frankenburg</surname> <given-names>FR</given-names></name> <name><surname>Hennen</surname> <given-names>J</given-names></name> <name><surname>Reich</surname> <given-names>DB</given-names></name> <name><surname>Silk</surname> <given-names>KR</given-names></name></person-group>. <article-title>Prediction of the 10-year course of borderline personality disorder.</article-title> <source><italic>Am J Psychiatry.</italic></source> (<year>2006</year>) <volume>163</volume>:<fpage>827</fpage>&#x2013;<lpage>32</lpage>. <pub-id pub-id-type="doi">10.1176/ajp.2006.163.5.827</pub-id> <pub-id pub-id-type="pmid">16648323</pub-id></citation></ref>
<ref id="B42"><label>42.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Soderstrom</surname> <given-names>H</given-names></name> <name><surname>Nilsson</surname> <given-names>T</given-names></name> <name><surname>Sjodin</surname> <given-names>A-K</given-names></name> <name><surname>Carlstedt</surname> <given-names>A</given-names></name> <name><surname>Forsman</surname> <given-names>A</given-names></name></person-group>. <article-title>The childhood-onset neuropsychiatric background to adulthood psychopathic traits and personality disorders.</article-title> <source><italic>Compr Psychiatry.</italic></source> (<year>2005</year>) <volume>46</volume>:<fpage>111</fpage>&#x2013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1016/j.comppsych.2004.07.030</pub-id> <pub-id pub-id-type="pmid">15723027</pub-id></citation></ref>
<ref id="B43"><label>43.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Krabbendam</surname> <given-names>AA</given-names></name> <name><surname>Colins</surname> <given-names>OF</given-names></name> <name><surname>Doreleijers</surname> <given-names>TA</given-names></name> <name><surname>van der Molen</surname> <given-names>E</given-names></name> <name><surname>Beekman</surname> <given-names>AT</given-names></name> <name><surname>Vermeiren</surname> <given-names>RR</given-names></name></person-group>. <article-title>Personality disorders in previously detained adolescent females: a prospective study.</article-title> <source><italic>American J Orthopsychiatry.</italic></source> (<year>2015</year>) <volume>85</volume>:<issue>63</issue>. <pub-id pub-id-type="doi">10.1037/ort0000032</pub-id> <pub-id pub-id-type="pmid">25420142</pub-id></citation></ref>
<ref id="B44"><label>44.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>van der Molen</surname> <given-names>E</given-names></name> <name><surname>Vermeiren</surname> <given-names>R</given-names></name> <name><surname>Krabbendam</surname> <given-names>A</given-names></name> <name><surname>Beekman</surname> <given-names>A</given-names></name> <name><surname>Doreleijers</surname> <given-names>T</given-names></name> <name><surname>Jansen</surname> <given-names>L</given-names></name></person-group>. <article-title>Detained adolescent females&#x2019; multiple mental health and adjustment problem outcomes in young adulthood.</article-title> <source><italic>J Child Psychol Psychiatry.</italic></source> (<year>2013</year>) <volume>54</volume>:<fpage>950</fpage>&#x2013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1111/jcpp.12044</pub-id> <pub-id pub-id-type="pmid">23343212</pub-id></citation></ref>
<ref id="B45"><label>45.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Washburn</surname> <given-names>JJ</given-names></name> <name><surname>Romero</surname> <given-names>EG</given-names></name> <name><surname>Welty</surname> <given-names>LJ</given-names></name> <name><surname>Abram</surname> <given-names>KM</given-names></name> <name><surname>Teplin</surname> <given-names>LA</given-names></name> <name><surname>McClelland</surname> <given-names>GM</given-names></name><etal/></person-group> <article-title>Development of antisocial personality disorder in detained youths: the predictive value of mental disorders.</article-title> <source><italic>J Consult Clin Psychol.</italic></source> (<year>2007</year>) <volume>75</volume>:<issue>221</issue>. <pub-id pub-id-type="doi">10.1037/0022-006X.75.2.221</pub-id> <pub-id pub-id-type="pmid">17469880</pub-id></citation></ref>
<ref id="B46"><label>46.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Schmid</surname> <given-names>M</given-names></name> <name><surname>K&#x00F6;lch</surname> <given-names>M</given-names></name> <name><surname>Fegert</surname> <given-names>J</given-names></name> <name><surname>Schmeck</surname> <given-names>K.</given-names></name></person-group> <source><italic>Abschlussbericht Modellversuch Abkl&#x00E4;rung und Zielerreichung in Station&#x00E4;ren Ma&#x00DF;nahmen (MAZ).</italic></source> <publisher-loc>Bern</publisher-loc>: <publisher-name>Bundesamt f&#x00FC;r Justiz</publisher-name> (<year>2013</year>).</citation></ref>
<ref id="B47"><label>47.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>First</surname> <given-names>M</given-names></name> <name><surname>Gibbon</surname> <given-names>M</given-names></name> <name><surname>Spitzer</surname> <given-names>R</given-names></name> <name><surname>Williams</surname> <given-names>J</given-names></name> <name><surname>Benjamin</surname> <given-names>L.</given-names></name></person-group> <source><italic>Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II).</italic></source> <publisher-loc>Washington, DC</publisher-loc>: <publisher-name>American Psychiatric Press</publisher-name> (<year>1997</year>).</citation></ref>
<ref id="B48"><label>48.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kaufman</surname> <given-names>J</given-names></name> <name><surname>Birmaher</surname> <given-names>B</given-names></name> <name><surname>Brent</surname> <given-names>D</given-names></name> <name><surname>Rao</surname> <given-names>U</given-names></name> <name><surname>Ryan</surname> <given-names>N.</given-names></name></person-group> <source><italic>Kiddie-Sads-Present and Lifetime Version (K-SADS-PL).</italic></source> <publisher-loc>Pittsburgh</publisher-loc>: <publisher-name>University of Pittsburgh, School of Medicine</publisher-name> (<year>1996</year>).</citation></ref>
<ref id="B49"><label>49.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>First</surname> <given-names>MB</given-names></name> <name><surname>Williams</surname> <given-names>JB</given-names></name> <name><surname>Karg</surname> <given-names>RS</given-names></name> <name><surname>Spitzer</surname> <given-names>RL.</given-names></name></person-group> <source><italic>User&#x2019;s Guide for the SCID-5-CV Structured Clinical Interview for DSM-5&#x00A7;Disorders: Clinical Version.</italic></source> <publisher-loc>Arlington, VA</publisher-loc>: <publisher-name>American Psychiatric Association Publishing</publisher-name> (<year>2016</year>).</citation></ref>
<ref id="B50"><label>50.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Os&#x00F3;rio</surname> <given-names>FL</given-names></name> <name><surname>Loureiro</surname> <given-names>SR</given-names></name> <name><surname>Hallak</surname> <given-names>JEC</given-names></name> <name><surname>Machado-de-Sousa</surname> <given-names>JP</given-names></name> <name><surname>Ushirohira</surname> <given-names>JM</given-names></name> <name><surname>Baes</surname> <given-names>CV</given-names></name><etal/></person-group> <article-title>Clinical validity and intrarater and test&#x2013;retest reliability of the structured clinical interview for DSM-5&#x2013;clinician version (SCID-5-CV).</article-title> <source><italic>Psychiatry Clin Neurosci.</italic></source> (<year>2019</year>) <volume>73</volume>:<fpage>754</fpage>&#x2013;<lpage>60</lpage>. <pub-id pub-id-type="doi">10.1111/pcn.12931</pub-id> <pub-id pub-id-type="pmid">31490607</pub-id></citation></ref>
<ref id="B51"><label>51.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Maffei</surname> <given-names>C</given-names></name> <name><surname>Fossati</surname> <given-names>A</given-names></name> <name><surname>Agostoni</surname> <given-names>I</given-names></name> <name><surname>Barraco</surname> <given-names>A</given-names></name> <name><surname>Bagnato</surname> <given-names>M</given-names></name> <name><surname>Deborah</surname> <given-names>D</given-names></name><etal/></person-group> <article-title>Interrater reliability and internal consistency of the structured clinical interview for DSM-IV Axis II personality disorders (SCID-II), version 2.0.</article-title> <source><italic>J Pers Disord.</italic></source> (<year>1997</year>) <volume>11</volume>:<fpage>279</fpage>&#x2013;<lpage>84</lpage>. <pub-id pub-id-type="doi">10.1521/pedi.1997.11.3.279</pub-id> <pub-id pub-id-type="pmid">9348491</pub-id></citation></ref>
<ref id="B52"><label>52.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Landis</surname> <given-names>JR</given-names></name> <name><surname>Koch</surname> <given-names>GG</given-names></name></person-group>. <article-title>The measurement of observer agreement for categorical data.</article-title> <source><italic>Biometrics.</italic></source> (<year>1977</year>) <volume>33</volume>:<fpage>159</fpage>&#x2013;<lpage>74</lpage>. <pub-id pub-id-type="pmid">843571</pub-id></citation></ref>
<ref id="B53"><label>53.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Pearson</surname> <given-names>KI</given-names></name></person-group>. <article-title>Mathematical contributions to the theory of evolution.&#x2013;VII. On the correlation of characters not quantitatively measurable.</article-title> <source><italic>Philos Trans R Soc Lond Ser A.</italic></source> (<year>1900</year>) <volume>195</volume>:<fpage>1</fpage>&#x2013;<lpage>47</lpage>.</citation></ref>
<ref id="B54"><label>54.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cohen</surname> <given-names>J.</given-names></name></person-group> <source><italic>Statistical Power Analysis for the Social Sciences.</italic></source> <publisher-loc>Hillsdale, NJ</publisher-loc>: <publisher-name>L Erlbaum</publisher-name> (<year>1988</year>).</citation></ref>
<ref id="B55"><label>55.</label><citation citation-type="journal"><collab>R Core Team.</collab> <source><italic>R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing.</italic></source> (<year>2020</year>). Available online at: <ext-link ext-link-type="uri" xlink:href="http://www.R-project.org/">http://www.R-project.org/</ext-link>. (<comment>accessed December 10, 2020</comment>).</citation></ref>
<ref id="B56"><label>56.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Birkh&#x00F6;lzer</surname> <given-names>M</given-names></name> <name><surname>B&#x00E4;r</surname> <given-names>N</given-names></name> <name><surname>Goth</surname> <given-names>K</given-names></name> <name><surname>Schmeck</surname> <given-names>K</given-names></name></person-group>. <article-title>Avoidant personality disorder in young people - a neglected mental health issue.</article-title> <source><italic>Front Psychiatry.</italic></source> (<year>2022</year>) <volume>13</volume>.</citation></ref>
<ref id="B57"><label>57.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Videler</surname> <given-names>AC</given-names></name> <name><surname>Hutsebaut</surname> <given-names>J</given-names></name> <name><surname>Schulkens</surname> <given-names>JEM</given-names></name> <name><surname>Sobczak</surname> <given-names>S</given-names></name> <name><surname>van Alphen</surname> <given-names>SPJ</given-names></name></person-group>. <article-title>A life span perspective on borderline personality disorder.</article-title> <source><italic>Curr Psychiatry Rep.</italic></source> (<year>2019</year>) <volume>21</volume>:<issue>51</issue>.</citation></ref>
<ref id="B58"><label>58.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Livanou</surname> <given-names>M</given-names></name> <name><surname>Furtado</surname> <given-names>V</given-names></name> <name><surname>Winsper</surname> <given-names>C</given-names></name> <name><surname>Silvester</surname> <given-names>A</given-names></name> <name><surname>Singh</surname> <given-names>SP</given-names></name></person-group>. <article-title>Prevalence of mental disorders and symptoms among incarcerated youth: a meta-analysis of 30 studies.</article-title> <source><italic>Int J Forensic Ment Health.</italic></source> (<year>2019</year>) <volume>18</volume>:<fpage>400</fpage>&#x2013;<lpage>14</lpage>. <pub-id pub-id-type="doi">10.1017/S0033291714000762</pub-id> <pub-id pub-id-type="pmid">25066071</pub-id></citation></ref>
<ref id="B59"><label>59.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Afifi</surname> <given-names>TO</given-names></name> <name><surname>Mather</surname> <given-names>A</given-names></name> <name><surname>Boman</surname> <given-names>J</given-names></name> <name><surname>Fleisher</surname> <given-names>W</given-names></name> <name><surname>Enns</surname> <given-names>MW</given-names></name> <name><surname>MacMillan</surname> <given-names>H</given-names></name><etal/></person-group> <article-title>Childhood adversity and personality disorders: results from a nationally representative population-based study.</article-title> <source><italic>J Psychiatr Res.</italic></source> (<year>2011</year>) <volume>45</volume>:<fpage>814</fpage>&#x2013;<lpage>22</lpage>. <pub-id pub-id-type="doi">10.1016/j.jpsychires.2010.11.008</pub-id> <pub-id pub-id-type="pmid">21146190</pub-id></citation></ref>
<ref id="B60"><label>60.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Reising</surname> <given-names>K</given-names></name> <name><surname>Farrington</surname> <given-names>DP</given-names></name> <name><surname>Ttofi</surname> <given-names>MM</given-names></name> <name><surname>Piquero</surname> <given-names>AR</given-names></name> <name><surname>Coid</surname> <given-names>JW</given-names></name></person-group>. <article-title>Childhood risk factors for personality disorder symptoms related to violence.</article-title> <source><italic>Aggress Violent Behav.</italic></source> (<year>2019</year>) <volume>49</volume>:<issue>101315</issue>.</citation></ref>
<ref id="B61"><label>61.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chanen</surname> <given-names>AM</given-names></name> <name><surname>Thompson</surname> <given-names>KN</given-names></name></person-group>. <article-title>The age of onset of personality disorders.</article-title> In: <person-group person-group-type="author"><name><surname>de Girolamo</surname> <given-names>G</given-names></name> <name><surname>McGorry</surname> <given-names>P</given-names></name> <name><surname>Sartorius</surname> <given-names>N</given-names></name></person-group> <role>editors.</role> <source><italic>Age of Onset of Mental Disorders.</italic></source> <publisher-loc>Cham</publisher-loc>: <publisher-name>Springer</publisher-name> (<year>2019</year>). <comment>p.</comment> <fpage>183</fpage>&#x2013;<lpage>201</lpage>.</citation></ref>
<ref id="B62"><label>62.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wertz</surname> <given-names>J</given-names></name> <name><surname>Caspi</surname> <given-names>A</given-names></name> <name><surname>Ambler</surname> <given-names>A</given-names></name> <name><surname>Arseneault</surname> <given-names>L</given-names></name> <name><surname>Belsky</surname> <given-names>DW</given-names></name> <name><surname>Danese</surname> <given-names>A</given-names></name><etal/></person-group> <article-title>Borderline symptoms at age 12 signal risk for poor outcomes during the transition to adulthood: findings from a genetically sensitive longitudinal cohort study.</article-title> <source><italic>J Am Acad Child Adolesc Psychiatry.</italic></source> (<year>2019</year>) <volume>59</volume>:<fpage>1165</fpage>&#x2013;<lpage>77</lpage>. <pub-id pub-id-type="doi">10.1016/j.jaac.2019.07.005</pub-id> <pub-id pub-id-type="pmid">31325594</pub-id></citation></ref>
<ref id="B63"><label>63.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Chanen</surname> <given-names>AM</given-names></name></person-group>. <article-title>Borderline personality disorder in young people: are we there yet?</article-title> <source><italic>J Clin Psychol.</italic></source> (<year>2015</year>) <volume>71</volume>:<fpage>778</fpage>&#x2013;<lpage>91</lpage>. <pub-id pub-id-type="doi">10.1002/jclp.22205</pub-id> <pub-id pub-id-type="pmid">26192914</pub-id></citation></ref>
<ref id="B64"><label>64.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bondurant</surname> <given-names>H</given-names></name> <name><surname>Greenfield</surname> <given-names>B</given-names></name> <name><surname>Tse</surname> <given-names>SM</given-names></name></person-group>. <article-title>Construct validity of the adolescent borderline personality disorder: a review.</article-title> <source><italic>Can Child Adolesc Psychiatry Rev.</italic></source> (<year>2004</year>) <volume>13</volume>:<issue>53</issue>. <pub-id pub-id-type="pmid">19030500</pub-id></citation></ref>
<ref id="B65"><label>65.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wade</surname> <given-names>J</given-names></name> <name><surname>Dixon</surname> <given-names>J</given-names></name></person-group>. <article-title>Making a home, finding a job: investigating early housing and employment outcomes for young people leaving care.</article-title> <source><italic>Child Family Soc Work.</italic></source> (<year>2006</year>) <volume>11</volume>:<fpage>199</fpage>&#x2013;<lpage>208</lpage>. <pub-id pub-id-type="doi">10.1111/j.1365-2206.2006.00428.x</pub-id></citation></ref>
<ref id="B66"><label>66.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Seker</surname> <given-names>S</given-names></name> <name><surname>Boonmann</surname> <given-names>C</given-names></name> <name><surname>Gerger</surname> <given-names>H</given-names></name> <name><surname>J&#x00E4;ggi</surname> <given-names>L</given-names></name> <name><surname>d&#x2019;Huart</surname> <given-names>D</given-names></name> <name><surname>Schmeck</surname> <given-names>K</given-names></name><etal/></person-group> <article-title>Mental disorders among adults formerly in out-of-home care: a systematic review and meta-analysis of longitudinal studies.</article-title> <source><italic>Eur Child Adolesc Psychiatry.</italic></source> (<year>2021</year>) <volume>1</volume>:<issue>20</issue>. <pub-id pub-id-type="doi">10.1007/s00787-021-01828-0</pub-id> <pub-id pub-id-type="pmid">34169369</pub-id></citation></ref>
<ref id="B67"><label>67.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Singer</surname> <given-names>J</given-names></name> <name><surname>Willet</surname> <given-names>J</given-names></name></person-group>. <article-title>A framework for investigating change over time.</article-title> <source><italic>Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence.</italic></source> <publisher-loc>Oxford</publisher-loc>: <publisher-name>Oxford University Press</publisher-name> (<year>2003</year>). <comment>p.</comment> <fpage>115</fpage>&#x2013;<lpage>39</lpage>.</citation></ref>
<ref id="B68"><label>68.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Barnett</surname> <given-names>AG</given-names></name> <name><surname>van der Pols</surname> <given-names>JC</given-names></name> <name><surname>Dobson</surname> <given-names>AJ</given-names></name></person-group>. <article-title>Regression to the mean: what it is and how to deal with it.</article-title> <source><italic>Int J Epidemiol.</italic></source> (<year>2005</year>) <volume>34</volume>:<fpage>215</fpage>&#x2013;<lpage>20</lpage>. <pub-id pub-id-type="doi">10.1093/ije/dyh299</pub-id> <pub-id pub-id-type="pmid">15333621</pub-id></citation></ref>
<ref id="B69"><label>69.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Arnett</surname> <given-names>JJ.</given-names></name></person-group> <source><italic>Emerging Adulthood: The Winding Road from the Late Teens Through the Twenties.</italic></source> <publisher-loc>Oxford</publisher-loc>: <publisher-name>Oxford University Press</publisher-name> (<year>2014</year>).</citation></ref>
<ref id="B70"><label>70.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hopwood</surname> <given-names>CJ</given-names></name> <name><surname>Donnellan</surname> <given-names>MB</given-names></name> <name><surname>Blonigen</surname> <given-names>DM</given-names></name> <name><surname>Krueger</surname> <given-names>RF</given-names></name> <name><surname>McGue</surname> <given-names>M</given-names></name> <name><surname>Iacono</surname> <given-names>WG</given-names></name><etal/></person-group> <article-title>Genetic and environmental influences on personality trait stability and growth during the transition to adulthood: a three-wave longitudinal study.</article-title> <source><italic>J Pers Soc Psychol.</italic></source> (<year>2011</year>) <volume>100</volume>:<issue>545</issue>. <pub-id pub-id-type="doi">10.1037/a0022409</pub-id> <pub-id pub-id-type="pmid">21244174</pub-id></citation></ref>
</ref-list>
</back>
</article>
