As of December 23, 2020, the COVID-19 pandemic has around 77 million cases of infection in more than 200 countries with above 1,711,000 overall deaths (1). Approximately 6 months after cases were first diagnosed, there remain few reliable treatments and no vaccines available, and an increasing number of countries are experiencing dangerous COVID-19 transmission (2, 3). Among vulnerable populations to infection and its complications are people with substance use disorders (SUDs) (4). Both comorbid medical conditions in SUDs (such as cardiopulmonary diseases and related risk factors) and drug–drug interactions (between COVID-19 medications and abused substances or SUD treatment medications), along with other factors, may lead to people with SUDs experiencing more complications when encountering COVID-19 infections (4–6).

People with SUDs are vulnerable given marginalization, stigmatization, and poor access to health and social services (7, 8). According to risky behaviors and disadvantaged environments associated with SUDs, people with SUD may not only bear additional risks for COVID-19 but also experience poorer outcomes (4). Therefore, during the pandemic, gathering current information on the status of SUD is critical to support planning and mobilizing timely responses to minimize risks (4). Alterations in alcohol and drug supplies may change prices and availability and therefore use patterns. The COVID-19 pandemic has resulted in quarantines, travel bans, regulatory changes, and social distancing “lockdown” measures globally, with impacts on supply chains. In the setting of COVID-19-related stressors, there may be decreases in drug and alcohol availability, increases in price and use patterns, and possible downstream effects on SUD presentations and treatment demands. Such changes could directly/indirectly affect people with SUDs and give rise to new challenges and additional needs in the field of addiction medicine. Drug shortages, as the United Nation Office for Drug and Crime (UNODC) reports, could have negative health consequences regarding transitioning to consumption of harmful domestically produced substances along with more dangerous patterns of drug use including shifting to injections and using shared drug administration equipment, especially in the case of heroin (9). Additionally, the lack of drug supply may result in higher prices for some substances and bring financial burden to drug users and increase the odds of risky/illegal behaviors (4). Concurrently, as legal liquor shops may remain closed during the lockdown in some countries, multiple problems may occur ranging from alcohol withdrawal to toxicity and death due to shifting to low-quality homemade liquor and accidental methanol ingestion (4, 10).

People with SUDs could be exposed to some indirect risks during the COVID-19 era as well (5). For instance, as healthcare facilities become more difficult to access during lockdowns, people with SUDs may experience more difficulties relating to poor access to treatment centers. Socioeconomically disadvantaged backgrounds and diminished availability of public transportation may exacerbate such concerns (4, 5, 11), especially for individuals receiving daily prescriptions of opioid substitution therapy (4). Professional authorities and health policymakers are expected to proactively address such emerging needs. However, the lack of reliable data complicates the generation and implementation of evidence-based policies.

Although some activities and reports from different worldwide organizations have initially responded to the COVID-19 pandemic, data provided have been limited and, in some occasions, as UNODC has reported, the information base for analyses has been restricted and feasibility of implementation unknown¹ (12– 16). Thus, a vacancy exists for a comprehensive report describing the global situation with respect to drug use, drug supply, and related complications.

In order to formulate a comprehensive health response, it is important to understand alcohol and drug markets' situation (availability and price), use patterns and related complications, and how they may have changed during the pandemic. Designing a global in-depth epidemiologic study, apart from questions about its feasibility, is challenging during the pandemic. Therefore, the International Society of Addiction Medicine (ISAM) designed a comprehensive global survey and collected expert opinions on perceived changes in substance use situation and health system responses around the 1st week of April 2020 in what aims to be a longitudinal study (17).

Here, we report results from the first round of the ISAM global survey on drug and alcohol use, price, supply, and complications during the COVID-19 pandemic. Data related to the second section of the survey concerning substance use treatment and harm reduction services responses to the pandemic have been published recently (18). We hypothesized that drug and alcohol use would increase, prices would increase, supply would decrease, and complications would increase and that results would differ by region (given the differential spread of COVID-19 and regional responses to the COVID-19 pandemic). We hope that current data will help to address the urgent need for more accurate information about the status of drug and alcohol use in the current pandemic and provide information about appropriate modifications in health system services to respond to the emerging demands in the current pandemic and similar potential pandemics in the future.

According to the results of this first-ever COVID-19 and SUD global survey with the contribution of 177 addiction medicine professionals/policymakers from 77 countries, the majority of respondents believed that in their countries, people with SUDs had been seriously affected by the COVID-19 outbreak. They mostly believed that prices for alcohol and drugs have risen, and they have become less available during the pandemic. In regard with alterations in use patterns, respondents perceived an increase the use of alcohol, cannabis, prescribed opioids, and sedative/hypnotics, and a decrease in the use of amphetamines, cocaine, and opiates. Most respondents reported increases in complications related to drug and alcohol use including increased morbidity and mortality in people with SUDs.

Alterations in levels of alcohol consumption during pandemic are similar to those reported during prior social crises, like the 2008–2009 economic downturn (19). Changes in alcohol consumption may arise from two potentially contradictory, however interacting mechanisms: (1) a problematic increase, usually stemming from distress that is being experienced especially at the beginning of a crisis, or in an attempt to “stockpile”; or (2) a decrease due to the lack of access and financial difficulties, which may lead to withdrawal (20). Current reports from Australia indicate increases in purchases of alcoholic beverages during lockdown potentially due to the first mechanism (21). However, India seems to be encountering a surge in numbers of individuals withdrawing from alcohol (5, 22). These independent reports from Australia and India are in line with our survey findings (Figure 2). Initial reports from Australia and the United States indicate overall increases in alcohol sales, especially in online alcohol delivery subsectors (21), although specific data from the industry on alcohol supply are largely lacking. However, there was no consensus among our survey respondents about changes in alcohol supply, as the responses that reported an increase, decrease, and no change were approximately equal. Approximately half of our survey respondents believed that there is no change in alcohol cost during the pandemic. This is while almost another half reported an increase in alcohol prices. We could not find any relevant reports indicating alcohol price alterations. Further data are needed as the pandemic progresses and hopefully resolves.

There are currently concerns about morbidity and mortality spikes within people with AUDs and alcohol-associated liver disease during the pandemic (23). The survey's results support the idea that these spikes can be seen among people with AUDs. Reports from Iran describe methanol poisoning of around 5,000 people with nearly 700 deaths, which may be due to lack of education and illegal and uncontrolled alcohol sales because of alcohol bans in Iran (10, 24, 25). However, to the best of our knowledge, there are yet no specific reports demonstrating the extent of alcohol overdose. The same pattern also applies to drug-related mortalities and morbidities.

Survey results suggest increases in cannabis use in more than half of participating countries. The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) has investigated this matter through three large darknet markets (26) in the first 3 months of 2020 and reported overall increased market activity, mostly in relation to cannabis products (13, 27). This might show the initial effects of the pandemic on the European countries market, particularly before peaks in the number of people infected by COVID-19 and subsequent widespread lockdowns.

Opiates, amphetamines, and cocaine were generally reported to have a decrease or no change in patterns of usage in most countries. During the 2008 global financial crisis, drug use patterns were differentially impacted, with expenditures of money for drugs down 2–44%, termed as the “Great Recession” of drug use (19). Although there are preliminary reports suggesting that opioid use is a risk factor for ICU admission in H1N1 infections and a possible risk factor for mortality following COVID-19 infection, rumors about protective effects of opium use in Iran may have led to increased consumption (28, 29). In the US, an already severe opioid overdose crisis worsened since the COVID-19 pandemic, with 30 out of 50 states reporting increases in overdoses between March and June of 2020, with an increase in high potency synthetic opioids such as fentanyl in street supplies and decreased access to harm reduction and OUD treatment services cited as possible drivers of overdose increase (30–32). While concerns have been also raised regarding probable effects of substances on COVID-19 patients (4, 33, 34), more research is needed on changes in drug use patterns and impacts on SUDs.

More than 80% of the countries reported increased use of sedatives and hypnotics. This rise in the demand for sedatives/hypnotics may be related to the stressful situation of the COVID-19 pandemic and its consequences. Survey results also suggest increased use of prescription opioids, perhaps for similar reasons, and changes in services may be needed (35, 36). Canada, Australia, United Kingdom, and Scotland facilitated pharmacy-based methadone-dispensing programs as prescribing opioid-related medications increased (36). This model may help to manage withdrawal syndromes during lockdown-related periods. In the United States, rapid changes in policies provided support to facilitate service delivery for people in opioid treatment programs, such as larger quantities of dispensed methadone and buprenorphine and relaxed regulations around virtual prescriber visits to initiate and continue medications for OUD in order to help patients access and maintain access to medications (35, 37).

The EMCDDA has reported recent increases in the drug demands in European markets (13). The EMCDDA has also noted that due to increases in the retail prices of cannabis and cocaine, the localized supply shortages may exist during the pandemic (12). The UNODC has reported that across all regions globally, many countries have noted a general shortage of different drugs at the retail level, mostly due to reduction in imports or strict lockdown rules, resulting in fewer personal interactions for drug sales (14). The UNODC has also noted a heterogeneous situation on bulk supply, both across drugs and across different countries (14). The UNODC preliminary data were gathered from governmental authorities and open sources (media and UNODC field officers) (14). Our results agree with multiple aspects of these reports of drug supplies.

The UNODC reported that countries with strict rules on social distancing such as the Czech Republic, United Kingdom, Italy, and Iran have been facing increased street drug prices due to lack of availability (14). Other reports from drug-producing countries suggest drug price decrements perhaps as a result of stockpiling of drugs (14). Subsequently, the EMCDDA along with the UNODC have both noted that COVID-19 restrictions have generally led to increases in drug prices, including cocaine, heroin, amphetamines, and cannabis, at the level of street markets (13, 14). Our survey results support these preliminary data reported by the UNODC and EMCDDA.

Respondents mostly reported increases in behavioral addictions during the current pandemic, which may partly confirm the existing concerns on this matter (38, 39). Other small studies suggest increases in addictive behaviors (39–41). Some forms of gambling may have decreased due to financial uncertainties, occupational problems, cessation of sporting events, closure of casinos, and other factors (40, 41). Discussing another addictive behavior, gaming has been represented to be a coping mechanism during the current stressful conditions (42). Accordingly, gaming has increased among college students in India, who use gaming as an antistress mechanism (42). Increased gaming has been occurring globally during the pandemic (43), as well as pornography viewing (44). These and other concerns have led to guidance about Internet use during the pandemic (45).

ISAM conducted the first global survey in the field of addiction medicine and successfully sampled responses from 77 countries and 177 experts globally. This timely and rapid survey was designed in a multistep fashion including literature review, expert communication, professional qualitative appraisal, and finally a pilot study (17) and was able to rapidly and reliably address urgent gaps in knowledge during the current pandemic. However, there are limitations such as heterogeneity the numbers of respondents from different countries and their disciplines and educational levels. The convenience sample also may impact response rates and other factors. The lack of validated measures is a limitation, as is the lack of options for open-ended responses that would provide a window on the mechanisms driving reported trends. The fact that not all the countries across the world are included in the study may question the nature of the word “global,” which has been used throughout the survey. Given the dynamic nature of pandemics and lack of multicentric epidemiological studies, the survey is a timely approach to provide a snapshot of global clinical addiction medicine concerns during these unprecedented times.

The objective of the ISAM survey was to provide initial, rapid preliminary evidence about how COVID-19 has affected different situational aspects experienced by people with SUDs globally in order to help reach a better understanding of the current status. Provision of this information to international organizations and regional policymakers should help authorities plan for addressing urgent needs and providing suitable services not only in the current pandemic but also in future similar situations. To properly respond to the emerging demands and situational shifts during the COVID-19 pandemic in the addiction treatment services across the world, at a macro (policy) level, it is critical to recognize the importance of (1) the social safety net and measures used to reduce the social inequality widening gap when such epidemics deteriorate an already vulnerable system, (2) responsive and publicly well-resourced healthcare with adequate supply of appropriate medication, (3) civil liberties, which could help increased participation and a judicious response by law enforcement agencies, and (4) policies that have taken in justifying alcohol sales and cannabis dispensaries as essential services and legislation allowing pharmacists to provide maintenance medications such as benzodiazepines in order to guarantee safe supplies. At a meso (organizational) level, it is important that clinical experience and knowledge on localized drug supply, price, and associated morbidities and mortality is shared within the organization in order to respond adequately. This makes it vital that organizations have a responsive continuity plan that can change with the needs of the population throughout the acute stage of the pandemic. It is also important to establish, support, and sustain varied digital platforms to allow better access to treatment for drug and alcohol using populations and minimize morbidities and possibly mortality. Establishing joint advocacy groups of service users and providers is also critical. At a micro (individual) level, it is important to (1) establish a mechanism for shared decision making through effective communication channels, (2) build the therapeutic environment that welcomes and encourages participation of peer, third sector, and/or frontline workers who are also involved in the care of the individuals in care, (3) support psychologically informed environments and interventions considering stress, uncertainties, isolation, and mental health, and (4) consider providing harm minimization and/or public protection messages and equipment to all in care and others.

In this unique global survey, experts in addiction medicine provided information on changes in regional alcohol and drug availability, price, usage, and related complications. Reported decreases in alcohol and drug supplies appear partly attributable to lockdowns, import/export limitations, and strict regulations. Reduced availability may have generated increases in prices. Reported increases in the use of alcohol, cannabis, prescribed opioids, and sedative/hypnotics may reflect their legal availability (in online markets, drugstores, and dispensaries), while decreased use of amphetamines, cocaine, and opiates may be related to decreased availability due to social distancing, lockdown regulations, and increased prices. Changed drug use patterns may not only impact people with SUDs but also give rise to risky behaviors and related complications. Most issues may potentially be preventable if future lockdown regulations are accompanied by enhanced service provision for at-risk communities.

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

The studies involving human participants were reviewed and approved by the survey protocols and all materials, including the survey questionnaires, received approval from the University of Social Welfare and Rehabilitation Sciences' ethics committee in Tehran, Iran (Code: IR.USWR.REC.1399.061). The participants provided their written informed consent to participate in this study.

AF, SR, HE, CD, and AB conceived and designed the study. AF, SR, PR, MV, HE, CD, and AB conducted the survey and collected the data. ME and PR analyzed the data and ran the statistical analyses. AF, SR, HE, CD, MY, and AB supervised the analysis and gave conceptual advice. HM, AZ, PR, and HE contributed to drafting the first draft of the manuscript. AB, MP, SA, and CK edited the manuscript. All authors discussed the results, implications, and commented on the final manuscript.

Adrian Octavian Abagiu¹, Franck David Noel Abouna², Mohamed Hassan Ahmed³, Basma Al-ansari⁴, Feda Mahmmoud Abu Al-khair⁵, Mandhar Humaid Almaqbali⁶, Atul Ambekar⁷, Sidharth Arya⁸, Victor Olufolahan Asebikan⁹, Murad Ali Ayasreh¹⁰, Debasish Basu¹¹, Zoubir Benmebarek¹², Roshan Bhad⁷, Mario Blaise¹³, Nicolas Bonnet¹⁴, Jennifer Brasch¹⁵, Barbara Broers¹⁶, Anja Busse¹⁷, Jenna L. Butner¹⁸, Moses Camilleri¹⁹, Giovanna Campello¹⁷, Giuseppe Carra²⁰, Ivan Celic²¹, Fatemeh Chalabianloo²², Abhishek Chaturvedi²³, José de Jesús Eduardo Noyola Cherpitel²⁴, Kelly J. Clark²⁵, Melissa Anne Cyders²⁶, Ernesto de Bernardis²⁷, Abbas Deilamizade²⁸, John Edward Derry²⁹, Naveen Kumar Dhagudu³⁰, Pavla Dolezalova³¹, Geert Dom³², Adrian John Dunlop³³, Mahmoud Mamdouh Elhabiby³⁴, Hussein Elkholy³⁵, Nsidibe Francis Essien³⁶, Ghandi Ilias Farah³⁷, Marica Ferri³⁸, Georgios D Floros³⁹, Catherine Friedman⁴⁰, Clara Hidalgo Fuderanan⁴¹, Gilberto Gerra¹⁷, Abhishek Ghosh⁴², Maka Gogia⁴³, Ilias A. Grammatikopoulos⁴⁴, Paolo Grandinetti⁴⁵, Amira Guirguis⁴⁶, David Gutnisky⁴⁷, Paul Steven Haber⁴⁸, Peyman Hassani-Abharian⁴⁹, Zahra Hooshyari⁵⁰, Islam Ibrahim Mokhtar Ibrahim³⁴, Hada Fong-ha Ieong⁵¹, Regina Nova Indradewi⁵², Shelly Iskandar⁵³, Thahir Noorul Isra⁵⁴, Shobhit Jain⁵⁵, Sandi James⁵⁶, Seyyed Mohammad hossein Javadi⁵⁷, Keun Ho Joe⁵⁸, Darius Jokubonis⁵⁹, Acka Tushevska Jovanova⁶⁰, Rama Mohamed Kamal⁶¹, Alexander Ivanov Kantchelov⁶², Preethy Kathiresan⁷, Gary Katzman⁶³, Paul Kawale⁶⁴, Audrey Margaret Kern⁶⁵, Felix Henrique Paim Kessler⁶⁶, Sung-Gon Sue Kim⁶⁷, Ann Marie Kimball⁶⁸, Zeljko Kljucevic⁶⁹, Kristiana Siste Kurniasanti⁷⁰, Roneet Lev⁷¹, Hae Kook Lee⁷², Aiste Lengvenyte⁷³, Shaul Lev-ran⁷⁴, Geni Seseja Mabelya⁷⁵, Mohamed Ali El Mahi⁷⁶, J. Maphisa Maphisa⁷⁷, Icro Maremmani⁷⁸, Laura Masferrer⁷⁹, Omid Massah⁸⁰, Orlagh McCambridge⁸¹, Garrett Gregory McGovern⁸², Aung Kyi Min⁸³, Amir Moghanibashi-Mansourieh⁵⁷, Jazman Mora-Rios⁸⁴, Indika Udaya Kumara Mudalige⁸⁵, Diptadhi Mukherjee⁸⁶, Pejic Munira Munira⁸⁷, Bronwyn Myers⁸⁸, Jayakrishnan Menon T. N.⁸⁹, Venkata Lakshmi Narasimha⁹⁰, Nkemakolam Ndionuka⁹¹, Ali-Akbar Nejatisafa⁹², Kamran Niaz¹⁷, Asad Tamizuddin Nizami⁹³, Jan H. Nuijens⁹⁴, Laura Orsolini⁹⁵, Vantheara Oum⁹⁶, Adegboyega Adekunle Oyemade⁹⁷, Irena Rojnia Palavra⁹⁸, Sagun Ballav Pant⁹⁹, Joselyn Paredes¹⁰⁰, Eric Peyron¹⁰¹, Randall Alberto Quirós¹⁰², Rouhollah Qurishi¹⁰³, Noor ul Zaman Rafiq¹⁰⁴, Ranjini Raghavendra Rao¹⁰⁵, Woraphat Ratta-apha¹⁰⁶, Karren-Lee Raymond¹⁰⁷, Jens Reimer¹⁰⁸, Eduardo Renaldo¹⁰⁹, Tara Rezapour¹¹⁰, James Roy Robertson¹¹¹, Carlos Roncero¹¹², Fazle Roub¹¹³, Elizabeth Jane Rubenstein¹¹⁴, Claudia Ines Rupp¹¹⁵, Elizabeth Saenz¹⁷, Mohammad Salehi¹¹⁶, Lampros Samartzis¹¹⁷, Laura Beatriz Sarubbo¹¹⁸, Nusa Segrec¹¹⁹, Bigya Shah¹²⁰, Hongxian Shen¹²¹, Tomohiro Shirasaka¹²², Steve Shoptaw¹²³, Fransiskus Muronga Sintango¹²⁴, Veronica Andrea Sosa¹²⁵, Emilis Subata¹²⁶, Norberto Sztycberg¹²⁷, Fatemeh Taghizadeh¹²⁸, Joseph Brian Tay Wee Teck¹²⁹, Christian Tjagvad¹³⁰, Marta Torrens¹³¹, Judith Meme Twala¹³², Ramyadarshni Vadivel¹³³, Joseph Robert Volpicelli¹³⁴, Jelmer Weijs¹³⁵, Steven Michael Wintoniw¹³⁶, Apisak Wittayanookulluk¹³⁷, Marcin Wojnar¹³⁸, Sadia Yasir⁹³, Yimenu Yitayih¹³⁹ and Min Zhao¹⁴⁰

¹National Institute for Infectious Diseases, Prof. Dr. Matei Bals- Arena OMT Department, Romania

²Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon

³Alamal psychiatric hospital, Dubai, United Arab Emirates

⁴Sydney Medical School, University of Sydney, NSW, Australia

⁵Al Ahliyya Amman University, Amman, Jordan

⁶Ministry of Health, Muscat, Oman

⁷Department of Psychiatry and National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India

⁸State Drug Dependence Treatment Centre, Institute of Mental Health, Pt BDS University of Health Sciences, India

⁹Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria

¹⁰Addiction Medicine Clinic, Jordan

¹¹Drug De-addiction and Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India

¹²Addiction Medicine Clinic, Mila, Algeria

¹³Centre medical Marmottan, France

¹⁴Réseau de Prévention des Addictions (RESPADD), France

¹⁵Department of Psychiatry and Behavioural Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

¹⁶Geneva University Hospitals, Switzerland

¹⁷United Nations Office on Drugs and Crime (UNODC), Vienna, Austria

¹⁸CUNY School of Medicine, New York, United States

¹⁹Agenzija Sedqa, Malta

²⁰Department of Medicine and Surgery, University Milan-Bicocca, Italy

²¹University Psychiatric Hospital Vrapce - Zagreb, Croatia

²²Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway

²³Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India

²⁴Addiction Medicine Clinic, Mexico

²⁵Addiction Crisis Solutions, United States

²⁶Department of Psychology, Indiana University Purdue University - Indianapolis, United States

²⁷SerT Lentini, ASP Siracusa, Italy

²⁸Rebirth Charity Society NGO, Tehran, Iran

²⁹Serenity Vista Addiction Treatment Center, Panama.

³⁰Department of Psychiatry, ESIC Medical College, Hyderabad, Telangana, India

³¹National Institute of Mental Health, Czech Republic

³²Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Belgium

³³Drug & Alcohol Clinical Services, Hunter New England Local Health District, Australia

³⁴Ain Shams University, Cairo, Egypt

³⁵Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt

³⁶Centre for Research and Information on Substance Abuse, Nigeria

³⁷Addiction Medicine Clinic, Syria

³⁸European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Italy

³⁹Department of Psychiatry, Aristotle University of Thessaloniki, Greece

⁴⁰Brown University and Lifespan Health System, Providence, Rhode Island, United States

⁴¹Fuderanan Mental Health Clinic, Philippines

⁴²Drug De-addiction & Treatment Centre, Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India

⁴³Georgian Harm Reduction Network, Georgia

⁴⁴Organization Against Drugs, Primary Care Health Center, Veria, Greece

⁴⁵Addictions Services (Ser.D.), Department of Territorial Services, ASL Teramo, Italy

⁴⁶Swansea University Medical School, Institute of Life Sciences 2, Singleton Campus, SA2 8PP, Wales, United Kingdom

⁴⁷Universidad de Buenos Aires, Argentina

⁴⁸University of Sydney, Australia

⁴⁹Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran

⁵⁰Tehran University of Medical Sciences, Tehran, Iran

⁵¹Department of Anesthesiology, Yale University, United States

⁵²Drugs Rehabilitation Center, National Narcotics Board of Indonesia, Indonesia

⁵³Department of Psychiatry, Universitas Padjadjaran, Bandung, West Java, Indonesia

⁵⁴National Institute of Education, Sri Lanka

⁵⁵Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India

⁵⁶Univeristi Malaysia Sabah, Malaysia

⁵⁷Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran

⁵⁸National Center for Mental Health of Korea, South Korea

⁵⁹Republican Center for Addictive Disorders, Lithuania

⁶⁰Addiction Medicine Clinic, North Macedonia

⁶¹Naufar Institute, Doha, Qatar

⁶²The Kantchelov Clinic, Sofia, Bulgaria

⁶³Mount Sinai Medical Center, New York, United States

⁶⁴African Institute for Development Policy, Malawi

⁶⁵Sobriety Centers of New Hampshire, United States

⁶⁶Federal University of Rio Grande do Sul, Brazil

⁶⁷Pusan National University Yangsan Hospital, Department of Neuropsychiatry, Yangsan South Korea

⁶⁸Chatham House, United States

⁶⁹Institute for Public Health of Split-Dalmatia County, Croatia

⁷⁰Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Indonesia

⁷¹Scripps Mercy Hospital, San Diego, United States

⁷²Department of Psychiatry, The Catholic University of Korea, Seoul, Korea

⁷³Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania

⁷⁴Israel Center on Addiction, Netanya, Israel

⁷⁵Community Health Work, Tanzania

⁷⁶Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan

⁷⁷University of Botswana, Botswana

⁷⁸V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Italy

⁷⁹CAS Girona, Department of Psychology, University of Girona, Spain

⁸⁰Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

⁸¹Community addiction team, Southern Health and Social Care Trust, Northern Ireland, United Kingdom

⁸²Priority Medical Clinic, Dublin, Ireland

⁸³Save the Children International Organization, Burma

⁸⁴Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México

⁸⁵Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defence University, Sri Lanka

⁸⁶Centre for Addiction Medicine, NIMHANS, Bangalore, India

⁸⁷Kleopatra Kodric, Irena Nisic, Slovenia

⁸⁸Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, South Africa

⁸⁹NIMHANS, Bangalore, India

⁹⁰Centre for Addiction Medicine, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India

⁹¹Federal Neuropsychiatric Hospital, Calabar, Nigeria

⁹²Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran

⁹³Institute of Psychiatry, WHO Collaborating Center for Mental Health, Pakistan

⁹⁴Brijder Addiction Care, Zaandam, Netherlands

⁹⁵Department of Clinical Neurosciences/DIMSC, School of Medicine, Polytechnic University of Marche, Ancona, Italy

⁹⁶Koh Kong Provincial Hospital, Cambodia.

⁹⁷Kaiser Permanente, United States

⁹⁸Psychiatric hospital Sveti Ivan, Zagreb, Croatia

⁹⁹Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Nepal

¹⁰⁰Universidad de El Salvador, El Salvador

¹⁰¹AddiPsy, Lyon, France

¹⁰²Addiction Medicine Clinic, Costa Rica

¹⁰³Novadic-Kentron Addiction Care Network, Vught, Netherlands

¹⁰⁴Phoenix Foundation for Research and Development, Pakistan

¹⁰⁵Barwon Health, Geelong, Australia

¹⁰⁶Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand

¹⁰⁷University of the Sunshine Coast (USC), Queensland, Australia

¹⁰⁸Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

¹⁰⁹Drugs Rehabilitation Center, National Narcotics Board of Indonesia

¹¹⁰Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran

¹¹¹Usher Institute, University of Edinburgh, United Kingdom

¹¹²Psychiatry Service, University of Salamanca Health Care Complex, Salamanca, Spain

¹¹³PGIMER, Chandigarh, India

¹¹⁴Street Health Centre, Canada

¹¹⁵Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck Austria

¹¹⁶Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

¹¹⁷Medical School, University of Cyprus, Cyprus

¹¹⁸Clínica Psiquiátrica de la Facultad de Medicina, Uruguay

¹¹⁹Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia

¹²⁰Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal

¹²¹Department of Psychiatry, Second Xiangya Hospital, Central South University, China

¹²²Department of Psychiatry, Teine Keijinkai Medical Center, Japan

¹²³David Geffen School of Medicine at UCLA, Department of Family Medicine, United States

¹²⁴Health Professions Councils of Namibia, Namibia

¹²⁵Addiction Medicine Clinic, Uruguay

¹²⁶Republican Center for Addictive Disorders, Lithuania

¹²⁷Asociasion Programa Andres Argentina, Argentina

¹²⁸Mazandaran University of Medical Sciences, Mazandaran, Iran

¹²⁹MRC/CSO SPHSU, University of Glasgow, United Kingdom

¹³⁰Gladsaxe Substance Use Disorder Treatment Centre, Denmark

¹³¹Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research Barcelona, Spain

¹³²NACADA, Kenya

¹³³Waikato District Health Board (WDHB) Hamilton, New Zealand

¹³⁴Institute of Addiction Medicine, United States

¹³⁵Jellinek, Amsterdam, Netherlands

¹³⁶Addictions Foundation of Manitoba, Canada

¹³⁷Thanyarak Chiangmai Hospital, Thailand

¹³⁸Medical University of Warsaw, Warsaw, Poland

¹³⁹Jimma University, Ethiopia

¹⁴⁰Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.