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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="systematic-review">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2017.00248</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Systematic Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Economic and Health Predictors of National Postpartum Depression Prevalence: A Systematic Review, Meta-analysis, and Meta-Regression of 291 Studies from 56 Countries</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Hahn-Holbrook</surname> <given-names>Jennifer</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x0002A;</xref>
<uri xlink:href="http://frontiersin.org/people/u/466068"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Cornwell-Hinrichs</surname> <given-names>Taylor</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="http://frontiersin.org/people/u/469749"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Anaya</surname> <given-names>Itzel</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://frontiersin.org/people/u/491393"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Department of Psychology, University of California, Merced</institution>, <addr-line>Merced, CA</addr-line>, <country>United States</country></aff>
<aff id="aff2"><sup>2</sup><institution>Center for Excellence in Biopsychosocial Approaches to Health, Chapman University</institution>, <addr-line>Orange, CA</addr-line>, <country>United States</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Health Sciences, Chapman University</institution>, <addr-line>Orange, CA</addr-line>, <country>United States</country></aff>
<aff id="aff4"><sup>4</sup><institution>Department of Psychology, Palo Alto University</institution>, <addr-line>Palo Alto, CA</addr-line>, <country>United States</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Gianluca Serafini, University of Genoa, Italy</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Erika Comasco, Uppsala University, Sweden; Taolin Chen, West China Hospital of Sichuan University, China</p></fn>
<corresp content-type="corresp" id="cor1">&#x0002A;Correspondence: Jennifer Hahn-Holbrook, <email>jhahn-holbrook&#x00040;ucmerced.edu</email></corresp>
<fn fn-type="other" id="fn001"><p>Specialty section: This article was submitted to Mood and Anxiety Disorders, a section of the journal Frontiers in Psychiatry</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>01</day>
<month>02</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="collection">
<year>2017</year>
</pub-date>
<volume>8</volume>
<elocation-id>248</elocation-id>
<history>
<date date-type="received">
<day>08</day>
<month>08</month>
<year>2017</year>
</date>
<date date-type="accepted">
<day>07</day>
<month>11</month>
<year>2017</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2018 Hahn-Holbrook, Cornwell-Hinrichs and Anaya.</copyright-statement>
<copyright-year>2018</copyright-year>
<copyright-holder>Hahn-Holbrook, Cornwell-Hinrichs and Anaya</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract abstract-type="executive-summary">
<sec id="ST1">
<title>Background</title>
<p>Postpartum depression (PPD) poses a major global public health challenge. PPD is the most common complication associated with childbirth and exerts harmful effects on children. Although hundreds of PPD studies have been published, we lack accurate global or national PPD prevalence estimates and have no clear account of why PPD appears to vary so dramatically between nations. Accordingly, we conducted a meta-analysis to estimate the global and national prevalence of PPD and a meta-regression to identify economic, health, social, or policy factors associated with national PPD prevalence.</p>
</sec>
<sec id="ST2">
<title>Methods</title>
<p>We conducted a systematic review of all papers reporting PPD prevalence using the Edinburgh Postnatal Depression Scale. PPD prevalence and methods were extracted from each study. Random effects meta-analysis was used to estimate global and national PPD prevalence. To test for country level predictors, we drew on data from UNICEF, WHO, and the World Bank. Random effects meta-regression was used to test national predictors of PPD prevalence.</p>
</sec>
<sec id="ST3">
<title>Findings</title>
<p>291 studies of 296284 women from 56 countries were identified. The global pooled prevalence of PPD was 17.7% (95% confidence interval: 16.6&#x02013;18.8%), with significant heterogeneity across nations (<italic>Q</italic>&#x02009;&#x0003D;&#x02009;16,823, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.000, <italic>I</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;98%), ranging from 3% (2&#x02013;5%) in Singapore to 38% (35&#x02013;41%) in Chile. Nations with significantly higher rates of income inequality (<italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;41%), maternal mortality (<italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;19%), infant mortality (<italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;16%), or women of childbearing age working &#x02265;40&#x02009;h a week (<italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;31%) have higher rates of PPD. Together, these factors explain 73% of the national variation in PPD prevalence.</p>
</sec>
<sec id="ST4">
<title>Interpretation</title>
<p>The global prevalence of PPD is greater than previously thought and varies dramatically by nation. Disparities in wealth inequality and maternal-child-health factors explain much of the national variation in PPD prevalence.</p>
</sec>
</abstract>
<kwd-group>
<kwd>depression</kwd>
<kwd>prevalence</kwd>
<kwd>gini index</kwd>
<kwd>postpartum</kwd>
<kwd>gross domestic product</kwd>
<kwd>pregnancy</kwd>
<kwd>infant mortality</kwd>
</kwd-group>
<counts>
<fig-count count="4"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="313"/>
<page-count count="23"/>
<word-count count="16334"/>
</counts>
</article-meta>
</front>
<body>
<sec id="S1" sec-type="introduction">
<title>Introduction</title>
<p>Maternal mental health problems pose major public health challenges for societies across the globe. For example, psychiatric illness (often associated with suicidality) is one of the leading causes of maternal death in the UK (<xref ref-type="bibr" rid="B1">1</xref>), as well as a leading killer of women of childbearing age in both India and China (<xref ref-type="bibr" rid="B2">2</xref>). The most common psychiatric malady following childbirth is postpartum depression (PPD), a devastating mental illness that can impair maternal behaviors (<xref ref-type="bibr" rid="B3">3</xref>, <xref ref-type="bibr" rid="B4">4</xref>) and adversely affect the cognitive, emotional, and behavioral development of children (<xref ref-type="bibr" rid="B5">5</xref>).</p>
<p>Three decades of interdisciplinary research have produced thousands of studies investigating the characteristics, measurement, consequences, treatment, and predictors of PPD. Despite these efforts, the global prevalence of PPD remains unknown. The widely cited PPD prevalence rate of 13% ascertained two-decades ago is based on a meta-analysis of overwhelmingly Western samples (<xref ref-type="bibr" rid="B6">6</xref>) and most likely do not reflect the incidence of PPD in the majority of the world&#x02019;s population. For example, a systematic review and meta-analysis that focused exclusively on low- and lower-middle income countries found a higher incidence of postpartum mental health disorders (<xref ref-type="bibr" rid="B7">7</xref>). However, this review, too, did not include wealthy nations for purposes of comparison, leaving open the possibility that the apparently inflated incidence of PPD in the developing world was an artifact of the different study methods employed in those societies (<xref ref-type="bibr" rid="B7">7</xref>). For example, low-income countries are more likely than high-income countries to rely on self-report PPD measures (rather than interviews) in the first weeks after birth (<xref ref-type="bibr" rid="B7">7</xref>), and we know that self-reported PPD measures taken earlier postpartum tend to yield higher PPD prevalence than interview tools given later. Accordingly, a meta-analysis comparing PPD prevalence, and taking into account divergent research methods used in high-, medium-, and low-income countries, is required to determine the true global and cross-national variation of PPD prevalence.</p>
<p>Further, to our knowledge, no prior large-scale meta-analysis has considered potential cross-national differences in PPD, despite qualitative evidence suggesting that PPD may vary dramatically from nation to nation even between nations of comparable economic standing (<xref ref-type="bibr" rid="B8">8</xref>, <xref ref-type="bibr" rid="B9">9</xref>). Reliable national PPD estimates could help to illumine particular economic, health, and policy factors that inflate or reduce PPD prevalence, thereby informing prevention efforts. Further, generating reliable national estimates of PPD could aid policy-makers in decisions about where to allocate limited resources, and alert global health agencies to direct aid to those countries most impacted.</p>
<p>Motivated by the potential health benefits of filling these knowledge gaps, we conducted the largest meta-analysis and meta-regression to date of global PPD prevalence. The present meta-analysis contains four times more studies, 22 times more women, and data from an additional 36 nations compared to the largest previous meta-analysis of PPD prevalence (<xref ref-type="bibr" rid="B6">6</xref>). We aimed to estimate PPD prevalence both globally and by nation and to explore whether divergent methodologies or disparities in health, economic, policy, or sociodemographic factors explain cross-national differences in PPD.</p>
</sec>
<sec id="S2" sec-type="methods">
<title>Methods</title>
<p>This study was comprised of three phases: (1) conducting a systematic review in accordance with PRISMA guidelines (<xref ref-type="bibr" rid="B10">10</xref>), (2) performing a meta-analyses to estimate PPD prevalence both globally and for each nation, and (3) using meta-regression to investigate whether methodological, economic, health, and/or policy factors predict cross-national variation in PPD.</p>
<sec id="S2-1">
<title>Search Strategy and Selection Criteria</title>
<p>To identify potentially eligible articles, we searched PubMed, PsychINFO, and CINAHL using a combination of the following MeSH terms in the abstract: (&#x0201C;postpartum depression&#x0201D; or &#x0201C;postnatal depression&#x0201D;) and (&#x0201C;incidence&#x0201D; or &#x0201C;prevalence&#x0201D;). In addition, we used the measures and instruments qualifier &#x0201C;edinburgh postnatal depression scale.&#x0201D; We further limited our search by only including studies of human females published in English between 1985 (just before the EPDS scale was published) and 2015. The exact Boolean searches used for each database are provided in Section &#x0201C;<xref ref-type="sec" rid="S10-1">Boolean Search Information</xref>&#x0201D; in the Appendix. Additionally, we reviewed three previously published comprehensive literature reviews of PPD prevalence (<xref ref-type="bibr" rid="B7">7</xref>&#x02013;<xref ref-type="bibr" rid="B9">9</xref>).</p>
<p>To be eligible for inclusion in this meta-analysis, studies were required to report PPD prevalence using the Edinburgh Postpartum Depression Scale (a 10-item self-report, widely used tool specially designed to measure PPD; EPDS) (<xref ref-type="bibr" rid="B11">11</xref>) on samples of mothers &#x02264;1&#x02009;year postpartum with a sample size &#x0003E;20. We chose to include studies conducted anytime in the first year postpartum because this is a convention used in the empirical literature (<xref ref-type="bibr" rid="B12">12</xref>) [despite the fact that the American Psychological Association categorizes PPD as occurring anytime in the first 4&#x02009;weeks postpartum (<xref ref-type="bibr" rid="B13">13</xref>), whereas PPD is defined as depression occurring anytime within the first 6&#x02009;weeks by the World Health Organization (<xref ref-type="bibr" rid="B14">14</xref>)]. To address the important issue of timing, we examined whether the timing of assessment influenced PPD prevalence through meta-regression in this paper. We also excluded studies reporting PPD prevalence in samples unlikely to be representative of the general population (e.g., studies that exclusively recruited women with a history of depression, teen mothers, immigrant mothers, abused mothers, mothers seeking treatment, mothers of high-risk infants, etc.).</p>
<p>291 studies (of 487 full-text articles assessed for eligibility) met these criteria and were included in this meta-analysis (see Figure <xref ref-type="fig" rid="F1">1</xref> for a PRISMA flow diagram reporting identification and selection of studies for the meta-analysis).</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p>PRISMA flow diagram reporting identification and selection of studies for the meta-analysis.</p></caption>
<graphic xlink:href="fpsyt-08-00248-g001.tif"/>
</fig>
<p>Studies using the EPDS to estimate PPD prevalence were the focus of this meta-analysis and meta-regression for several reasons. First, a recent systematic review of the validated screening tools for common mental disorder strongly recommended the use of the EPDS because it consistently performs well on metrics of internal and external validity, is easy enough to administer in resource-limited settings, and does not include the word &#x0201C;depression&#x0201D; which is stigmatized in some cultures (<xref ref-type="bibr" rid="B15">15</xref>). Second, there are advantages to keeping the type of screening tool used consistent across countries when trying to quantify and illuminate the causes of cross-national variability. For example, the wealth of a country strongly determines the type of PPD screening tool used (<xref ref-type="bibr" rid="B16">16</xref>) (e.g., it is harder to use time-intensive clinical interviews in resource-poor settings yet easier in resource-rich settings), and the type of screening tool used can influence PPD prevalence (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B17">17</xref>). Had we included multiple screening tools that differed on ease of administration (e.g., self-report vs. clinical interviews), it would have been difficult to determine whether any observed cross-national variance in PPD prevalence was due to disparities in national wealth or merely an artifact of the assessment tool used. Third, the EPDS had been widely translated and validated for use in at least 18 languages and exhibits good cross-cultural reliability (<xref ref-type="bibr" rid="B18">18</xref>). In addition, an examination of previously published systematic reviews showed that roughly 70% of studies used the EPDS to assess PPD prevalence (<xref ref-type="bibr" rid="B6">6</xref>, <xref ref-type="bibr" rid="B8">8</xref>, <xref ref-type="bibr" rid="B9">9</xref>). Therefore, the use of the EPDS allowed us to include the majority of studies while limiting confounding variables associated with different types of measurement (<xref ref-type="bibr" rid="B8">8</xref>). Finally, because the EPDS is specifically designed for administration in the postpartum period, the scale does not include items assessing changes in appetite, sleep, or weight. Changes in these factors are normal in the postpartum period, yet these somatic items are included as indicators of depression by other self-report screening tools designed to assess depression outside of the postpartum window (e.g., Patient Health Questionnaire-PHQ-9, The Hamilton Rating Scale for Depression-HAM-D, Center for Epidemiologic Studies Depression Scale-CESD, Beck Depression Inventory-BDI, and Zung&#x02019;s Self-Rating Depression Scale-SDS).</p>
</sec>
<sec id="S2-2">
<title>Data Extraction</title>
<p>The following methodological variables were coded from each study: PPD prevalence, total sample size, EPDS cutoff score employed, and the timeframe postpartum in which PPD was assessed. Because meta-analysis requires one estimate of PPD prevalence per study, data from longitudinal studies reporting PPD in the same women at multiple time points were consolidated by averaging the PPD prevalence over the time points weighted by the sample size at each time point. Also, if multiple prevalence rates were reported in the same study using different EPDS cutoffs, the prevalence rate from the lowest EPDS cutoff was chosen by default. This decision could cause a bias toward higher estimates of PPD incidence; therefore, we also used meta-regression to estimate PPD prevalence at the standard recommended EPDS cutoffs for possible (9/10) and probable (12/13) PPD (<xref ref-type="bibr" rid="B11">11</xref>).</p>
<p>To investigate whether studies including women earlier or later in the postpartum period report higher PPD prevalence, we created scores for each study reflecting the range of the timeframes postpartum during which PPD was assessed.</p>
</sec>
<sec id="S2-3">
<title>National Data</title>
<p>Various methodological, health, economic, policy, and sociodemographic variables were explored as potential predictors of cross-national variation in PPD. Potential cross-national predictors of PPD were chosen because they had been previously hypothesized to predict PPD and reliable national data were available for the majority of counties represented in this meta-analysis. See Data Sheet S1 in Supplementary Material for an Excel file containing all of the national data used.</p>
<sec id="S2-3-1">
<title>Methodological Variables</title>
<p>A previous meta-analysis of PPD suggested that it is important to rule out the possibility that cross-national variation in PPD prevalence is explained by methodological conventions used in different countries (<xref ref-type="bibr" rid="B7">7</xref>). For example, it is important to know whether systematic methodological differences like assessing PPD earlier postpartum or using higher/lower EPDS cutoff scores are employed in some countries more often than others. Further, if methodological conventions do differ across countries, we need to know the extent to which these explain the apparent cross-national variation in PPD prevalence. To explore this possibility, country sample-size-weighted national averages for each methodological variable were calculated for use in meta-regression models. In addition, we used meta-regression to assess whether the number of studies conducted in a country predicted cross-national PPD prevalence.</p>
</sec>
<sec id="S2-3-2">
<title>Health Variables</title>
<p>Health variables were obtained from UNICEF (<xref ref-type="bibr" rid="B19">19</xref>) unless otherwise noted and included infant mortality rate (the probability of dying between birth and age one, expressed per 1,000 live births), lifetime risk of maternal death (the annual number of deaths of women from pregnancy-related causes per 100,000 live births), total fertility rate (the number of children that would be born per woman if she were to live to the end of her childbearing years and bear children in accordance with prevailing age-specific fertility rates), and percentage of low-birthweight infants (born weighing &#x0003C;2,500&#x02009;g). Percentage of cesarean births was obtained from the World Health Report (<xref ref-type="bibr" rid="B20">20</xref>).</p>
</sec>
<sec id="S2-3-3">
<title>Economic and Policy Variables</title>
<p>GINI index (an index of the income distribution of a nation&#x02019;s residents wherein higher values indicate greater wealth inequality) data were obtained from Ortiz and Cummins (<xref ref-type="bibr" rid="B21">21</xref>). Gross Domestic Product (GDP) per capita (in adjusted US dollars) and percentage of women working &#x02265;40&#x02009;h a week (aged 25&#x02013;30) data were obtained from the Annual labor force statistics (<xref ref-type="bibr" rid="B22">22</xref>). Additionally, we investigated national provisions for paid and unpaid maternity leave available from the international labor office (<xref ref-type="bibr" rid="B23">23</xref>).</p>
</sec>
<sec id="S2-3-4">
<title>Sociodemographic Predictors</title>
<p>The percentage of children living in single parent homes and the percentage of infants born outside of marriage data were obtained from the World Family Map (<xref ref-type="bibr" rid="B24">24</xref>). The percentage of urbanized population data were also obtained from UNICEF.</p>
</sec>
</sec>
<sec id="S2-4">
<title>Data Analysis</title>
<p>Following the recommendations for meta-analysis of prevalence (<xref ref-type="bibr" rid="B25">25</xref>), we used a double-arcsine transformation of the PPD prevalence data before calculating the study weights and 95% confidence intervals (CIs) to avoid the undue large weights obtained for studies with low or high prevalence (prevalence close to 0 or 1). To test for heterogeneity in the data, both the Cochran <italic>Q</italic> test statistic and the <italic>I</italic><sup>2</sup> statistic were consulted (<xref ref-type="bibr" rid="B26">26</xref>). The same procedure was followed to create meta-analytically derived national estimates of PPD prevalence based solely on the studies available from each country. Meta-analytic estimates of PPD prevalence could not be calculated in countries with fewer than two studies (<italic>N</italic>&#x02009;&#x0003D;&#x02009;16) (<xref ref-type="bibr" rid="B27">27</xref>). All meta-analyses were conducted using the program MetaXL and the &#x0201C;prev&#x0201D; command (<xref ref-type="bibr" rid="B25">25</xref>).</p>
<p>Two sets of meta-regressions were performed, the first addressing which methodological factors predicted variation in PPD across all studies, regardless of the nation in which the study was conducted, and the second addressing predictors of PPD variation across nations. All meta-regression analyses were performed with STATA 14 (<xref ref-type="bibr" rid="B28">28</xref>) using the &#x0201C;metareg&#x0201D; command with random-effects models (because all tests indicated significant heterogeneity). To obtain the SEs needed to weight studies (or nations) for meta-regression in STATA, we transformed the 95%-CIs provided by MetaXL using the following formula (upper 95% CI&#x02009;&#x02212;&#x02009;lower 95% CI)/3.92. Because national data were not available for all variables, the number of countries included is reported for each meta-regression result using national variables.</p>
<p>Funnel plots, Doi plot analysis, and the LFK index were used to assess potential publication bias. Specifically, to test whether papers are more or less likely to be published due to higher/lower PPD prevalence.</p>
<p>Statistical significance was evaluated using 2-tailed 0.05-level tests.</p>
</sec>
</sec>
<sec id="S3">
<title>Results</title>
<sec id="S3-1">
<title>Meta-Analysis of Global PPD Prevalence</title>
<p>296,284 women from 291 studies were included in this meta-analysis. Table <xref ref-type="table" rid="T1">1</xref> presents the data extracted from each study. The global pooled prevalence of PPD was 17.7% (95% CI: 16.6 to 18.8%; see Figure S1 in Supplementary Material). There was a significant degree of heterogeneity between studies (<italic>Q</italic>&#x02009;&#x0003D;&#x02009;16,823, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.000, <italic>I</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;98%). Adjusting for the recommended EPDS cutoffs yielded a global PPD prevalence of 21.0% (CI: 19.1 to 23.0%) for possible PPD and 16.7% (CI: 14.9 to 18.6%) for probable PPD. See Figure S1 in Supplementary Material for meta-analytically derived PPD estimates for each individual study. There was evidence of publication bias based on sample size (LFK&#x02009;&#x0003D;&#x02009;1.98; see Funnel Plot in Figure <xref ref-type="fig" rid="F2">2</xref>).</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p>Studies included in meta-analysis.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Reference</th>
<th align="center" valign="top"><italic>n</italic></th>
<th align="center" valign="top">Depression prevalence (%)</th>
<th align="center" valign="top">Cut-off used</th>
<th align="center" valign="top">Postpartum assessment (weeks)</th>
<th align="center" valign="top">Country</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">102</td>
<td align="center" valign="top">15.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="23">Australia</td>
</tr>
<tr>
<td align="left" valign="top">Alcorn et al. (<xref ref-type="bibr" rid="B30">30</xref>)</td>
<td align="center" valign="top">866</td>
<td align="center" valign="top">14.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Armstrong et al. (<xref ref-type="bibr" rid="B31">31</xref>)</td>
<td align="center" valign="top">114</td>
<td align="center" valign="top">26.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top">Astbury et al. (<xref ref-type="bibr" rid="B32">32</xref>)</td>
<td align="center" valign="top">790</td>
<td align="center" valign="top">15.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">32&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top">Bilszta et al. (<xref ref-type="bibr" rid="B33">33</xref>)</td>
<td align="center" valign="top">1,966</td>
<td align="center" valign="top">7.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Boyce and Hickey (<xref ref-type="bibr" rid="B34">34</xref>)</td>
<td align="center" valign="top">425</td>
<td align="center" valign="top">9.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Boyce et al (<xref ref-type="bibr" rid="B35">35</xref>)</td>
<td align="center" valign="top">103</td>
<td align="center" valign="top">12.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Brooks et al. (<xref ref-type="bibr" rid="B36">36</xref>)</td>
<td align="center" valign="top">3,853</td>
<td align="center" valign="top">6.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Brown and Lumley (<xref ref-type="bibr" rid="B37">37</xref>)</td>
<td align="center" valign="top">1,331</td>
<td align="center" valign="top">19.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Buist et al. (<xref ref-type="bibr" rid="B38">38</xref>)</td>
<td align="center" valign="top">12,361</td>
<td align="center" valign="top">15.5</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Condon and Corkindale (<xref ref-type="bibr" rid="B39">39</xref>)</td>
<td align="center" valign="top">212</td>
<td align="center" valign="top">6.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Eastwood et al. (<xref ref-type="bibr" rid="B40">40</xref>)</td>
<td align="center" valign="top">25,455</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Eastwood et al. (<xref ref-type="bibr" rid="B41">41</xref>)</td>
<td align="center" valign="top">15,389</td>
<td align="center" valign="top">16.9</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">2&#x02013;3</td>
</tr>
<tr>
<td align="left" valign="top">Edwards et al. (<xref ref-type="bibr" rid="B42">42</xref>)</td>
<td align="center" valign="top">421</td>
<td align="center" valign="top">29.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top">Griepsma et al. (<xref ref-type="bibr" rid="B43">43</xref>)</td>
<td align="center" valign="top">185</td>
<td align="center" valign="top">57.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Leigh and Milgrom (<xref ref-type="bibr" rid="B44">44</xref>)</td>
<td align="center" valign="top">161</td>
<td align="center" valign="top">11.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">10&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Maloney (<xref ref-type="bibr" rid="B45">45</xref>)</td>
<td align="center" valign="top">399</td>
<td align="center" valign="top">18.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Miller et al. (<xref ref-type="bibr" rid="B46">46</xref>)</td>
<td align="center" valign="top">325</td>
<td align="center" valign="top">25.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Stamp and Crowther (<xref ref-type="bibr" rid="B47">47</xref>)</td>
<td align="center" valign="top">222</td>
<td align="center" valign="top">9.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Stamp et al. (<xref ref-type="bibr" rid="B48">48</xref>)</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">17.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">White et al. (<xref ref-type="bibr" rid="B49">49</xref>)</td>
<td align="center" valign="top">316</td>
<td align="center" valign="top">20.3</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Willinck and Cotton (<xref ref-type="bibr" rid="B50">50</xref>)</td>
<td align="center" valign="top">358</td>
<td align="center" valign="top">7.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Wynter et al. (<xref ref-type="bibr" rid="B51">51</xref>)</td>
<td align="center" valign="top">172</td>
<td align="center" valign="top">12.2</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Kohl et al. (<xref ref-type="bibr" rid="B52">52</xref>)</td>
<td align="center" valign="top">95</td>
<td align="center" valign="top">9.5</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1</td>
<td align="center" valign="top">Austria</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Al Dallal and Grant (<xref ref-type="bibr" rid="B53">53</xref>)</td>
<td align="center" valign="top">237</td>
<td align="center" valign="top">37.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">8</td>
<td align="center" valign="top">Bahrain</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Edhborg et al. (<xref ref-type="bibr" rid="B54">54</xref>)</td>
<td align="center" valign="top">674</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8&#x02013;12</td>
<td align="center" valign="top" rowspan="2">Bangladesh</td>
</tr>
<tr>
<td align="left" valign="top">Gausia et al. (<xref ref-type="bibr" rid="B55">55</xref>)</td>
<td align="center" valign="top">346</td>
<td align="center" valign="top">22.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Da-Silva et al. (<xref ref-type="bibr" rid="B56">56</xref>)</td>
<td align="center" valign="top">21</td>
<td align="center" valign="top">42.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4</td>
<td align="center" valign="top" rowspan="10">Brazil</td>
</tr>
<tr>
<td align="left" valign="top">de Almeida et al. (<xref ref-type="bibr" rid="B57">57</xref>)</td>
<td align="center" valign="top">222</td>
<td align="center" valign="top">16.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top">Filha et al. (<xref ref-type="bibr" rid="B58">58</xref>)</td>
<td align="center" valign="top">12,764</td>
<td align="center" valign="top">25.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top">Lobato et al. (<xref ref-type="bibr" rid="B59">59</xref>)</td>
<td align="center" valign="top">811</td>
<td align="center" valign="top">24.3</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">0&#x02013;20</td>
</tr>
<tr>
<td align="left" valign="top">Lobato et al. (<xref ref-type="bibr" rid="B60">60</xref>)</td>
<td align="center" valign="top">456</td>
<td align="center" valign="top">24.8</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Matijasevich et al. (<xref ref-type="bibr" rid="B61">61</xref>)</td>
<td align="center" valign="top">4,109</td>
<td align="center" valign="top">13.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Melo et al. (<xref ref-type="bibr" rid="B62">62</xref>)</td>
<td align="center" valign="top">555</td>
<td align="center" valign="top">10.8</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Morais et al. (<xref ref-type="bibr" rid="B63">63</xref>)</td>
<td align="center" valign="top">87</td>
<td align="center" valign="top">19.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">16&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Pinheiro et al. (<xref ref-type="bibr" rid="B64">64</xref>)</td>
<td align="center" valign="top">207</td>
<td align="center" valign="top">20.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Silva et al. (<xref ref-type="bibr" rid="B65">65</xref>)</td>
<td align="center" valign="top">1,109</td>
<td align="center" valign="top">16.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Bernazzani et al. (<xref ref-type="bibr" rid="B66">66</xref>)</td>
<td align="center" valign="top">213</td>
<td align="center" valign="top">12.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
<td align="center" valign="top" rowspan="13">Canada</td>
</tr>
<tr>
<td align="left" valign="top">Bowen et al. (<xref ref-type="bibr" rid="B67">67</xref>)</td>
<td align="center" valign="top">649</td>
<td align="center" valign="top">8.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">DaCosta et al. (<xref ref-type="bibr" rid="B68">68</xref>)</td>
<td align="center" valign="top">78</td>
<td align="center" valign="top">63.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4&#x02013;38</td>
</tr>
<tr>
<td align="left" valign="top">Dennis and Letourneau (<xref ref-type="bibr" rid="B69">69</xref>)</td>
<td align="center" valign="top">498</td>
<td align="center" valign="top">8.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Dennis and Ross (<xref ref-type="bibr" rid="B70">70</xref>)</td>
<td align="center" valign="top">425</td>
<td align="center" valign="top">14.1</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Dennis and Vigod (<xref ref-type="bibr" rid="B71">71</xref>)</td>
<td align="center" valign="top">497</td>
<td align="center" valign="top">20.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Dennis et al. (<xref ref-type="bibr" rid="B72">72</xref>)</td>
<td align="center" valign="top">498</td>
<td align="center" valign="top">24.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Dennis et al. (<xref ref-type="bibr" rid="B73">73</xref>)</td>
<td align="center" valign="top">315</td>
<td align="center" valign="top">7.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Malta et al. (<xref ref-type="bibr" rid="B74">74</xref>)</td>
<td align="center" valign="top">972</td>
<td align="center" valign="top">10.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">16</td>
</tr>
<tr>
<td align="left" valign="top">McDonald et al. (<xref ref-type="bibr" rid="B75">75</xref>)</td>
<td align="center" valign="top">1,578</td>
<td align="center" valign="top">13.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">16</td>
</tr>
<tr>
<td align="left" valign="top">Sword et al. (<xref ref-type="bibr" rid="B76">76</xref>)</td>
<td align="center" valign="top">2,560</td>
<td align="center" valign="top">7.6</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Verreault et al. (<xref ref-type="bibr" rid="B77">77</xref>)</td>
<td align="center" valign="top">226</td>
<td align="center" valign="top">16.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Vigod et al. (<xref ref-type="bibr" rid="B78">78</xref>)</td>
<td align="center" valign="top">6,126</td>
<td align="center" valign="top">7.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Florenzano et al. (<xref ref-type="bibr" rid="B79">79</xref>)</td>
<td align="center" valign="top">88</td>
<td align="center" valign="top">50.0</td>
<td align="center" valign="top"/>
<td align="center" valign="top">0&#x02013;2</td>
<td align="center" valign="top" rowspan="4">Chile</td>
</tr>
<tr>
<td align="left" valign="top">Jadresic et al. (<xref ref-type="bibr" rid="B80">80</xref>)</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">28.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Jadresic et al. (<xref ref-type="bibr" rid="B81">81</xref>)</td>
<td align="center" valign="top">542</td>
<td align="center" valign="top">36.7</td>
<td align="center" valign="top"/>
<td align="center" valign="top">8&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Risco et al. (<xref ref-type="bibr" rid="B82">82</xref>)</td>
<td align="center" valign="top">103</td>
<td align="center" valign="top">37.6</td>
<td align="center" valign="top"/>
<td align="center" valign="top">1&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Gao et al. (<xref ref-type="bibr" rid="B83">83</xref>)</td>
<td align="center" valign="top">130</td>
<td align="center" valign="top">13.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;8</td>
<td align="center" valign="top" rowspan="5">China</td>
</tr>
<tr>
<td align="left" valign="top">Gao et al. (<xref ref-type="bibr" rid="B84">84</xref>)</td>
<td align="center" valign="top">126</td>
<td align="center" valign="top">14.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Leung et al. (<xref ref-type="bibr" rid="B85">85</xref>)</td>
<td align="center" valign="top">694</td>
<td align="center" valign="top">7.2</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Xie et al. (<xref ref-type="bibr" rid="B86">86</xref>)</td>
<td align="center" valign="top">300</td>
<td align="center" valign="top">17.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Xie et al. (<xref ref-type="bibr" rid="B87">87</xref>)</td>
<td align="center" valign="top">534</td>
<td align="center" valign="top">19.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Nielsen Forman et al. (<xref ref-type="bibr" rid="B88">88</xref>)</td>
<td align="center" valign="top">5,091</td>
<td align="center" valign="top">5.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">Denmark</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">58</td>
<td align="center" valign="top">21.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="3">Finland</td>
</tr>
<tr>
<td align="left" valign="top">Hiltunen et al. (<xref ref-type="bibr" rid="B89">89</xref>)</td>
<td align="center" valign="top">185</td>
<td align="center" valign="top">14.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top">Luoma et al. (<xref ref-type="bibr" rid="B90">90</xref>)</td>
<td align="center" valign="top">147</td>
<td align="center" valign="top">10.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">de Tychey et al. (<xref ref-type="bibr" rid="B91">91</xref>)</td>
<td align="center" valign="top">277</td>
<td align="center" valign="top">11.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4&#x02013;8</td>
<td align="center" valign="top" rowspan="6">France</td>
</tr>
<tr>
<td align="left" valign="top">Frossey et al. (<xref ref-type="bibr" rid="B93">93</xref>)</td>
<td align="center" valign="top">126</td>
<td align="center" valign="top">11.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Gaillard et al. (<xref ref-type="bibr" rid="B94">94</xref>)</td>
<td align="center" valign="top">264</td>
<td align="center" valign="top">16.7</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Glangeaud-Freudenthal and Kaminski (<xref ref-type="bibr" rid="B95">95</xref>)</td>
<td align="center" valign="top">604</td>
<td align="center" valign="top">11.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Guendeney and Fermanian (<xref ref-type="bibr" rid="B96">96</xref>)</td>
<td align="center" valign="top">87</td>
<td align="center" valign="top">73.5</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">16</td>
</tr>
<tr>
<td align="left" valign="top">Sutter-Dallay et al. (<xref ref-type="bibr" rid="B97">97</xref>)</td>
<td align="center" valign="top">497</td>
<td align="center" valign="top">5.8</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Ballestrem et al. (<xref ref-type="bibr" rid="B98">98</xref>)</td>
<td align="center" valign="top">772</td>
<td align="center" valign="top">17.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;8</td>
<td align="center" valign="top" rowspan="5">Germany</td>
</tr>
<tr>
<td align="left" valign="top">Bergant et al. (<xref ref-type="bibr" rid="B99">99</xref>)</td>
<td align="center" valign="top">110</td>
<td align="center" valign="top">19.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Mehta et al. (<xref ref-type="bibr" rid="B100">100</xref>)</td>
<td align="center" valign="top">419</td>
<td align="center" valign="top">11.2</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1&#x02013;32</td>
</tr>
<tr>
<td align="left" valign="top">Reck et al. (<xref ref-type="bibr" rid="B101">101</xref>)</td>
<td align="center" valign="top">891</td>
<td align="center" valign="top">23.6</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">2&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Zaers et al. (<xref ref-type="bibr" rid="B102">102</xref>)</td>
<td align="center" valign="top">50</td>
<td align="center" valign="top">21.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Chatzi et al. (<xref ref-type="bibr" rid="B103">103</xref>)</td>
<td align="center" valign="top">529</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;10</td>
<td align="center" valign="top" rowspan="5">Greece</td>
</tr>
<tr>
<td align="left" valign="top">Gonidakis et al. (<xref ref-type="bibr" rid="B104">104</xref>)</td>
<td align="center" valign="top">402</td>
<td align="center" valign="top">19.8</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Koutra et al. (<xref ref-type="bibr" rid="B105">105</xref>)</td>
<td align="center" valign="top">438</td>
<td align="center" valign="top">13.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Lambrinoudaki et al. (<xref ref-type="bibr" rid="B106">106</xref>)</td>
<td align="center" valign="top">57</td>
<td align="center" valign="top">23.5</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">1&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Thorpe et al. (<xref ref-type="bibr" rid="B107">107</xref>)</td>
<td align="center" valign="top">165</td>
<td align="center" valign="top">13.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">106</td>
<td align="center" valign="top">53.3</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top">Guyana</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Lau and Chan (<xref ref-type="bibr" rid="B108">108</xref>)</td>
<td align="center" valign="top">1,200</td>
<td align="center" valign="top">34.4</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1</td>
<td align="center" valign="top">Hong Kong</td>
</tr>
<tr>
<td align="left" valign="top">Lee et al. (<xref ref-type="bibr" rid="B109">109</xref>)</td>
<td align="center" valign="top">145</td>
<td align="center" valign="top">11.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Lee et al. (<xref ref-type="bibr" rid="B110">110</xref>)</td>
<td align="center" valign="top">244</td>
<td align="center" valign="top">24.2</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Leung et al. (<xref ref-type="bibr" rid="B111">111</xref>)</td>
<td align="center" valign="top">269</td>
<td align="center" valign="top">19.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Tiwari et al. (<xref ref-type="bibr" rid="B112">112</xref>)</td>
<td align="center" valign="top">3,036</td>
<td align="center" valign="top">69.9</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Nagy et al. (<xref ref-type="bibr" rid="B113">113</xref>)</td>
<td align="center" valign="top">988</td>
<td align="center" valign="top">10.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">3&#x02013;26</td>
<td align="center" valign="top">Hungary</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Thome (<xref ref-type="bibr" rid="B114">114</xref>)</td>
<td align="center" valign="top">734</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;12</td>
<td align="center" valign="top">Iceland</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">110</td>
<td align="center" valign="top">33.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="7">India</td>
</tr>
<tr>
<td align="left" valign="top">Dubey et al. (<xref ref-type="bibr" rid="B92">92</xref>)</td>
<td align="center" valign="top">293</td>
<td align="center" valign="top">6.1</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Ghosh and Goswami (<xref ref-type="bibr" rid="B115">115</xref>)</td>
<td align="center" valign="top">6,000</td>
<td align="center" valign="top">25.08</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Jain et al. (<xref ref-type="bibr" rid="B116">116</xref>)</td>
<td align="center" valign="top">1,537</td>
<td align="center" valign="top">7.31</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Mariam and Srinivasan (<xref ref-type="bibr" rid="B117">117</xref>)</td>
<td align="center" valign="top">132</td>
<td align="center" valign="top">30.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;10</td>
</tr>
<tr>
<td align="left" valign="top">Patel et al. (<xref ref-type="bibr" rid="B118">118</xref>)</td>
<td align="center" valign="top">134</td>
<td align="center" valign="top">48.5</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Patel et al. (<xref ref-type="bibr" rid="B119">119</xref>)</td>
<td align="center" valign="top">270</td>
<td align="center" valign="top">23.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Andajani-Sutjahjo et al. (<xref ref-type="bibr" rid="B120">120</xref>)</td>
<td align="center" valign="top">274</td>
<td align="center" valign="top">7.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;24</td>
<td align="center" valign="top">Indonesia</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Abbasi et al. (<xref ref-type="bibr" rid="B121">121</xref>)</td>
<td align="center" valign="top">416</td>
<td align="center" valign="top">34.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top" rowspan="5">Iran</td>
</tr>
<tr>
<td align="left" valign="top">Abdollahi et al. (<xref ref-type="bibr" rid="B122">122</xref>)</td>
<td align="center" valign="top">2,083</td>
<td align="center" valign="top">19.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Goshtasebi et al. (<xref ref-type="bibr" rid="B123">123</xref>)</td>
<td align="center" valign="top">281</td>
<td align="center" valign="top">5.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Kheirabadi and Maracy (<xref ref-type="bibr" rid="B124">124</xref>)</td>
<td align="center" valign="top">1,291</td>
<td align="center" valign="top">26.3</td>
<td align="center" valign="top">14</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Montazeri et al. (<xref ref-type="bibr" rid="B125">125</xref>)</td>
<td align="center" valign="top">100</td>
<td align="center" valign="top">20.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;14</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Ahmed et al. (<xref ref-type="bibr" rid="B126">126</xref>)</td>
<td align="center" valign="top">1,000</td>
<td align="center" valign="top">28.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;8</td>
<td align="center" valign="top">Iraq</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Crotty and Sheehan (<xref ref-type="bibr" rid="B127">127</xref>)</td>
<td align="center" valign="top">625</td>
<td align="center" valign="top">27.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top" rowspan="4">Ireland</td>
</tr>
<tr>
<td align="left" valign="top">Cryan et al. (<xref ref-type="bibr" rid="B128">128</xref>)</td>
<td align="center" valign="top">377</td>
<td align="center" valign="top">28.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Lane et al. (<xref ref-type="bibr" rid="B129">129</xref>)</td>
<td align="center" valign="top">242</td>
<td align="center" valign="top">11.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Leahy-Warren et al. (<xref ref-type="bibr" rid="B130">130</xref>)</td>
<td align="center" valign="top">410</td>
<td align="center" valign="top">12.3</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Alfayumi-Zeadna et al. (<xref ref-type="bibr" rid="B131">131</xref>)</td>
<td align="center" valign="top">564</td>
<td align="center" valign="top">31.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4&#x02013;28</td>
<td align="center" valign="top" rowspan="8">Israel</td>
</tr>
<tr>
<td align="left" valign="top">Bloch et al. (<xref ref-type="bibr" rid="B132">132</xref>)</td>
<td align="center" valign="top">210</td>
<td align="center" valign="top">33.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Bloch et al. (<xref ref-type="bibr" rid="B133">133</xref>)</td>
<td align="center" valign="top">1,286</td>
<td align="center" valign="top">6.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Dankner et al. (<xref ref-type="bibr" rid="B134">134</xref>)</td>
<td align="center" valign="top">327</td>
<td align="center" valign="top">11.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6&#x02013;10</td>
</tr>
<tr>
<td align="left" valign="top">Eilat-Tsanani et al. (<xref ref-type="bibr" rid="B135">135</xref>)</td>
<td align="center" valign="top">574</td>
<td align="center" valign="top">9.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Fisch et al. (<xref ref-type="bibr" rid="B136">136</xref>)</td>
<td align="center" valign="top">327</td>
<td align="center" valign="top">5.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Glasser et al. (<xref ref-type="bibr" rid="B137">137</xref>)</td>
<td align="center" valign="top">288</td>
<td align="center" valign="top">22.6</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Glasser et al. (<xref ref-type="bibr" rid="B138">138</xref>)</td>
<td align="center" valign="top">104</td>
<td align="center" valign="top">43.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">100</td>
<td align="center" valign="top">55.5</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="9">Italy</td>
</tr>
<tr>
<td align="left" valign="top">Benvenuti et al. (<xref ref-type="bibr" rid="B139">139</xref>)</td>
<td align="center" valign="top">113</td>
<td align="center" valign="top">38.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Carpiniello et al. (<xref ref-type="bibr" rid="B140">140</xref>)</td>
<td align="center" valign="top">61</td>
<td align="center" valign="top">29.5</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Elisei et al. (<xref ref-type="bibr" rid="B141">141</xref>)</td>
<td align="center" valign="top">54</td>
<td align="center" valign="top">13.9</td>
<td align="center" valign="top">13.00</td>
<td align="center" valign="top">1&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Giardinelli et al. (<xref ref-type="bibr" rid="B142">142</xref>)</td>
<td align="center" valign="top">590</td>
<td align="center" valign="top">13.2</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Gorman et al. (<xref ref-type="bibr" rid="B143">143</xref>)</td>
<td align="center" valign="top">21</td>
<td align="center" valign="top">9.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Grussu and Quantraro (<xref ref-type="bibr" rid="B144">144</xref>)</td>
<td align="center" valign="top">297</td>
<td align="center" valign="top">13.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Mauri et al. (<xref ref-type="bibr" rid="B145">145</xref>)</td>
<td align="center" valign="top">751</td>
<td align="center" valign="top">10.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Oppo et al. (<xref ref-type="bibr" rid="B146">146</xref>)</td>
<td align="center" valign="top">600</td>
<td align="center" valign="top">6.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Matsumoto (<xref ref-type="bibr" rid="B147">147</xref>)</td>
<td align="center" valign="top">675</td>
<td align="center" valign="top">14.8</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top" rowspan="10">Japan</td>
</tr>
<tr>
<td align="left" valign="top">Miyake et al. (<xref ref-type="bibr" rid="B148">148</xref>)</td>
<td align="center" valign="top">865</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">8&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top">Nishigori et al. (<xref ref-type="bibr" rid="B149">149</xref>)</td>
<td align="center" valign="top">677</td>
<td align="center" valign="top">21.3</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">24&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top">Nishizono-Maher et al. (<xref ref-type="bibr" rid="B150">150</xref>)</td>
<td align="center" valign="top">1,048</td>
<td align="center" valign="top">13.9</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">12&#x02013;16</td>
</tr>
<tr>
<td align="left" valign="top">Ohoka et al. (<xref ref-type="bibr" rid="B151">151</xref>)</td>
<td align="center" valign="top">388</td>
<td align="center" valign="top">10.3</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Shimizu et al. (<xref ref-type="bibr" rid="B152">152</xref>)</td>
<td align="center" valign="top">65</td>
<td align="center" valign="top">12.3</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">4&#x02013;16</td>
</tr>
<tr>
<td align="left" valign="top">Tamaki et al. (<xref ref-type="bibr" rid="B153">153</xref>)</td>
<td align="center" valign="top">627</td>
<td align="center" valign="top">18.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Ueda et al. (<xref ref-type="bibr" rid="B154">154</xref>)</td>
<td align="center" valign="top">70</td>
<td align="center" valign="top">27.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Watanabe et al. (<xref ref-type="bibr" rid="B155">155</xref>)</td>
<td align="center" valign="top">235</td>
<td align="center" valign="top">12.8</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Yamashita et al. (<xref ref-type="bibr" rid="B156">156</xref>)</td>
<td align="center" valign="top">75</td>
<td align="center" valign="top">16.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">97</td>
<td align="center" valign="top">36.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="3">Korea</td>
</tr>
<tr>
<td align="left" valign="top">Bang (<xref ref-type="bibr" rid="B157">157</xref>)</td>
<td align="center" valign="top">137</td>
<td align="center" valign="top">22.6</td>
<td align="center" valign="top"/>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Kim et al. (<xref ref-type="bibr" rid="B158">158</xref>)</td>
<td align="center" valign="top">239</td>
<td align="center" valign="top">12.6</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Chaaya et al. (<xref ref-type="bibr" rid="B159">159</xref>)</td>
<td align="center" valign="top">396</td>
<td align="center" valign="top">21.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12&#x02013;20</td>
<td align="center" valign="top" rowspan="2">Lebanon</td>
</tr>
<tr>
<td align="left" valign="top">El-Hachem et al. (<xref ref-type="bibr" rid="B160">160</xref>)</td>
<td align="center" valign="top">228</td>
<td align="center" valign="top">33.3</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Dow et al. (<xref ref-type="bibr" rid="B161">161</xref>)</td>
<td align="center" valign="top">154</td>
<td align="center" valign="top">8.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">10&#x02013;14</td>
<td align="center" valign="top">Malawi</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Azidah et al. (<xref ref-type="bibr" rid="B162">162</xref>)</td>
<td align="center" valign="top">377</td>
<td align="center" valign="top">22.8</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1</td>
<td align="center" valign="top" rowspan="4">Malaysia</td>
</tr>
<tr>
<td align="left" valign="top">Kadir et al. (<xref ref-type="bibr" rid="B163">163</xref>)</td>
<td align="center" valign="top">293</td>
<td align="center" valign="top">24.9</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Kit et al. (<xref ref-type="bibr" rid="B164">164</xref>)</td>
<td align="center" valign="top">154</td>
<td align="center" valign="top">3.9</td>
<td align="center" valign="top">14</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Yusuf et al. (<xref ref-type="bibr" rid="B165">165</xref>)</td>
<td align="center" valign="top">1,362</td>
<td align="center" valign="top">14.3</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Felice et al. (<xref ref-type="bibr" rid="B166">166</xref>)</td>
<td align="center" valign="top">229</td>
<td align="center" valign="top">8.7</td>
<td align="center" valign="top"/>
<td align="center" valign="top">8</td>
<td align="center" valign="top">Malta</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">deCastro et al. (<xref ref-type="bibr" rid="B167">167</xref>)</td>
<td align="center" valign="top">298</td>
<td align="center" valign="top">14.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;36</td>
<td align="center" valign="top">Mexico</td>
</tr>
<tr>
<td align="left" valign="top">Flores-Quijano et al. (<xref ref-type="bibr" rid="B168">168</xref>)</td>
<td align="center" valign="top">163</td>
<td align="center" valign="top">24.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">2&#x02013;12</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Agoub et al. (<xref ref-type="bibr" rid="B169">169</xref>)</td>
<td align="center" valign="top">144</td>
<td align="center" valign="top">20.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">2&#x02013;3</td>
<td align="center" valign="top" rowspan="2">Morocco</td>
</tr>
<tr>
<td align="left" valign="top">Alami et al. (<xref ref-type="bibr" rid="B170">170</xref>)</td>
<td align="center" valign="top">100</td>
<td align="center" valign="top">21.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">0&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">D&#x000F8;rheim Ho-Yen et al. (<xref ref-type="bibr" rid="B171">171</xref>)</td>
<td align="center" valign="top">426</td>
<td align="center" valign="top">4.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">5&#x02013;10</td>
<td align="center" valign="top" rowspan="2">Nepal</td>
</tr>
<tr>
<td align="left" valign="top">Regmi et al. (<xref ref-type="bibr" rid="B172">172</xref>)</td>
<td align="center" valign="top">100</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Blom et al. (<xref ref-type="bibr" rid="B173">173</xref>)</td>
<td align="center" valign="top">4,941</td>
<td align="center" valign="top">8.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">8</td>
<td align="center" valign="top" rowspan="2">Netherlands</td>
</tr>
<tr>
<td align="left" valign="top">Verkerk et al. (<xref ref-type="bibr" rid="B174">174</xref>)</td>
<td align="center" valign="top">277</td>
<td align="center" valign="top">8.2</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">12&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Abbott and Williams (<xref ref-type="bibr" rid="B175">175</xref>)</td>
<td align="center" valign="top">1,376</td>
<td align="center" valign="top">16.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top" rowspan="4">New Zealand</td>
</tr>
<tr>
<td align="left" valign="top">Holt (<xref ref-type="bibr" rid="B176">176</xref>)</td>
<td align="center" valign="top">121</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">McGill et al. (<xref ref-type="bibr" rid="B177">177</xref>)</td>
<td align="center" valign="top">1,330</td>
<td align="center" valign="top">20.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">24&#x02013;36</td>
</tr>
<tr>
<td align="left" valign="top">Webster et al. (<xref ref-type="bibr" rid="B178">178</xref>)</td>
<td align="center" valign="top">206</td>
<td align="center" valign="top">7.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Abiodun (<xref ref-type="bibr" rid="B179">179</xref>)</td>
<td align="center" valign="top">360</td>
<td align="center" valign="top">18.6</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top" rowspan="4">Nigeria</td>
</tr>
<tr>
<td align="left" valign="top">Adewuya et al. (<xref ref-type="bibr" rid="B180">180</xref>)</td>
<td align="center" valign="top">478</td>
<td align="center" valign="top">20.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">0&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Adewuya et al. (<xref ref-type="bibr" rid="B181">181</xref>)</td>
<td align="center" valign="top">876</td>
<td align="center" valign="top">14.6</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Bakare et al. (<xref ref-type="bibr" rid="B182">182</xref>)</td>
<td align="center" valign="top">408</td>
<td align="center" valign="top">24.8</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">D&#x000F8;rheim et al. (<xref ref-type="bibr" rid="B183">183</xref>)</td>
<td align="center" valign="top">2,791</td>
<td align="center" valign="top">16.5</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top" rowspan="9">Norway</td>
</tr>
<tr>
<td align="left" valign="top">D&#x000F8;rheim et al. (<xref ref-type="bibr" rid="B184">184</xref>)</td>
<td align="center" valign="top">2,088</td>
<td align="center" valign="top">23.9</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Eberhand-Gran et al. (<xref ref-type="bibr" rid="B185">185</xref>)</td>
<td align="center" valign="top">56</td>
<td align="center" valign="top">26.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Eberhand-Gran et al. (<xref ref-type="bibr" rid="B186">186</xref>)</td>
<td align="center" valign="top">2,370</td>
<td align="center" valign="top">8.9</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Eberhard-Gran et al. (<xref ref-type="bibr" rid="B187">187</xref>)</td>
<td align="center" valign="top">473</td>
<td align="center" valign="top">9.1</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Glavin et al. (<xref ref-type="bibr" rid="B188">188</xref>)</td>
<td align="center" valign="top">2,227</td>
<td align="center" valign="top">10.1</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Haga et al. (<xref ref-type="bibr" rid="B189">189</xref>)</td>
<td align="center" valign="top">737</td>
<td align="center" valign="top">13.6</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;26</td>
</tr>
<tr>
<td align="left" valign="top">Markhus et al. (<xref ref-type="bibr" rid="B190">190</xref>)</td>
<td align="center" valign="top">43</td>
<td align="center" valign="top">6.9</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">13</td>
</tr>
<tr>
<td align="left" valign="top">Nordeng et al. (<xref ref-type="bibr" rid="B191">191</xref>)</td>
<td align="center" valign="top">1,984</td>
<td align="center" valign="top">8.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">17</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Ahmad and Khan (<xref ref-type="bibr" rid="B192">192</xref>)</td>
<td align="center" valign="top">876</td>
<td align="center" valign="top">14.6</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top" rowspan="2">Pakistan</td>
</tr>
<tr>
<td align="left" valign="top">Husain et al. (<xref ref-type="bibr" rid="B193">193</xref>)</td>
<td align="center" valign="top">149</td>
<td align="center" valign="top">36.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Ayoub (<xref ref-type="bibr" rid="B194">194</xref>)</td>
<td align="center" valign="top">235</td>
<td align="center" valign="top">17.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">2&#x02013;12</td>
<td align="center" valign="top">Palestine</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Duedek et al. (<xref ref-type="bibr" rid="B195">195</xref>)</td>
<td align="center" valign="top">344</td>
<td align="center" valign="top">16.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;12</td>
<td align="center" valign="top">Poland</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Augusto et al. (<xref ref-type="bibr" rid="B196">196</xref>)</td>
<td align="center" valign="top">588</td>
<td align="center" valign="top">12.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;20</td>
<td align="center" valign="top" rowspan="5">Portugal</td>
</tr>
<tr>
<td align="left" valign="top">Figueiredo and Conde (<xref ref-type="bibr" rid="B197">197</xref>)</td>
<td align="center" valign="top">260</td>
<td align="center" valign="top">14.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">0&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Figueiredo and Costa (<xref ref-type="bibr" rid="B198">198</xref>)</td>
<td align="center" valign="top">91</td>
<td align="center" valign="top">26.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">13</td>
</tr>
<tr>
<td align="left" valign="top">Figueiredo et al. (<xref ref-type="bibr" rid="B199">199</xref>)</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">17.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Gorman et al. (<xref ref-type="bibr" rid="B143">143</xref>)</td>
<td align="center" valign="top">48</td>
<td align="center" valign="top">9.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Chee et al. (<xref ref-type="bibr" rid="B200">200</xref>)</td>
<td align="center" valign="top">278</td>
<td align="center" valign="top">6.8</td>
<td align="center" valign="top">7</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top" rowspan="2">Singapore</td>
</tr>
<tr>
<td align="left" valign="top">Kok et al. (<xref ref-type="bibr" rid="B201">201</xref>)</td>
<td align="center" valign="top">200</td>
<td align="center" valign="top">0.5</td>
<td align="center" valign="top">16</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Lawrie et al. (<xref ref-type="bibr" rid="B202">202</xref>)</td>
<td align="center" valign="top">180</td>
<td align="center" valign="top">36.2</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top" rowspan="2">South Africa</td>
</tr>
<tr>
<td align="left" valign="top">Lawrie et al. (<xref ref-type="bibr" rid="B203">203</xref>)</td>
<td align="center" valign="top">103</td>
<td align="center" valign="top">36.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Escriba-Aguir and Artazcoz (<xref ref-type="bibr" rid="B204">204</xref>)</td>
<td align="center" valign="top">420</td>
<td align="center" valign="top">9.8</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">12&#x02013;52</td>
<td align="center" valign="top" rowspan="3">Spain</td>
</tr>
<tr>
<td align="left" valign="top">Garcia-Esteve et al. (<xref ref-type="bibr" rid="B205">205</xref>)</td>
<td align="center" valign="top">1,201</td>
<td align="center" valign="top">21.7</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Sebasti&#x000E1;n Romero et al. (<xref ref-type="bibr" rid="B206">206</xref>)</td>
<td align="center" valign="top">190</td>
<td align="center" valign="top">13.2</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">108</td>
<td align="center" valign="top">13.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="9">Sweden</td>
</tr>
<tr>
<td align="left" valign="top">Agnafors et al. (<xref ref-type="bibr" rid="B207">207</xref>)</td>
<td align="center" valign="top">1,707</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">B&#x000E5;gedahl-Strindlund and B&#x000F6;rjesson (<xref ref-type="bibr" rid="B208">208</xref>)</td>
<td align="center" valign="top">309</td>
<td align="center" valign="top">14.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Josefsson et al. (<xref ref-type="bibr" rid="B209">209</xref>)</td>
<td align="center" valign="top">1,192</td>
<td align="center" valign="top">13.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Lundh and Gyllang (<xref ref-type="bibr" rid="B210">210</xref>)</td>
<td align="center" valign="top">258</td>
<td align="center" valign="top">8.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Rubertsson et al. (<xref ref-type="bibr" rid="B211">211</xref>)</td>
<td align="center" valign="top">2,430</td>
<td align="center" valign="top">12.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Seimyr et al. (<xref ref-type="bibr" rid="B212">212</xref>)</td>
<td align="center" valign="top">326</td>
<td align="center" valign="top">14.6</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Sylven et al. (<xref ref-type="bibr" rid="B213">213</xref>)</td>
<td align="center" valign="top">2,318</td>
<td align="center" valign="top">10.6</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Wickberg and Hwang (<xref ref-type="bibr" rid="B214">214</xref>)</td>
<td align="center" valign="top">1,655</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Burgut et al. (<xref ref-type="bibr" rid="B215">215</xref>)</td>
<td align="center" valign="top">1,379</td>
<td align="center" valign="top">17.6</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1&#x02013;24</td>
<td align="center" valign="top">Qatar</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Alharbi and Abdulghani (<xref ref-type="bibr" rid="B216">216</xref>)</td>
<td align="center" valign="top">352</td>
<td align="center" valign="top">33.2</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8&#x02013;12</td>
<td align="center" valign="top" rowspan="2">Saudi Arabia</td>
</tr>
<tr>
<td align="left" valign="top">Al-Modayfer et al. (<xref ref-type="bibr" rid="B217">217</xref>)</td>
<td align="center" valign="top">571</td>
<td align="center" valign="top">13.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">5</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Gorman et al. (<xref ref-type="bibr" rid="B143">143</xref>)</td>
<td align="center" valign="top">60</td>
<td align="center" valign="top">6.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
<td align="center" valign="top" rowspan="3">Switzerland</td>
</tr>
<tr>
<td align="left" valign="top">G&#x000FC;rber et al. (<xref ref-type="bibr" rid="B218">218</xref>)</td>
<td align="center" valign="top">219</td>
<td align="center" valign="top">13.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;3</td>
</tr>
<tr>
<td align="left" valign="top">Righetti-Veltema et al. (<xref ref-type="bibr" rid="B219">219</xref>)</td>
<td align="center" valign="top">570</td>
<td align="center" valign="top">10.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">99</td>
<td align="center" valign="top">67.3</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
<td align="center" valign="top" rowspan="10">Taiwan</td>
</tr>
<tr>
<td align="left" valign="top">Chen et al. (<xref ref-type="bibr" rid="B220">220</xref>)</td>
<td align="center" valign="top">226</td>
<td align="center" valign="top">18.2</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Chien et al. (<xref ref-type="bibr" rid="B221">221</xref>)</td>
<td align="center" valign="top">190</td>
<td align="center" valign="top">8.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Heh et al. (<xref ref-type="bibr" rid="B222">222</xref>)</td>
<td align="center" valign="top">186</td>
<td align="center" valign="top">21.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Heh et al. (<xref ref-type="bibr" rid="B223">223</xref>)</td>
<td align="center" valign="top">400</td>
<td align="center" valign="top">23.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Huang and Mathers (<xref ref-type="bibr" rid="B224">224</xref>)</td>
<td align="center" valign="top">101</td>
<td align="center" valign="top">19.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Huang and Mathers (<xref ref-type="bibr" rid="B225">225</xref>)</td>
<td align="center" valign="top">106</td>
<td align="center" valign="top">25.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Lee et al. (<xref ref-type="bibr" rid="B226">226</xref>)</td>
<td align="center" valign="top">60</td>
<td align="center" valign="top">25.0</td>
<td align="center" valign="top">14</td>
<td align="center" valign="top">5&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Teng et al. (<xref ref-type="bibr" rid="B227">227</xref>)</td>
<td align="center" valign="top">203</td>
<td align="center" valign="top">10.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Tsao et al. (<xref ref-type="bibr" rid="B228">228</xref>)</td>
<td align="center" valign="top">162</td>
<td align="center" valign="top">24.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Limlomwongse and Liabsuetrakul (<xref ref-type="bibr" rid="B229">229</xref>)</td>
<td align="center" valign="top">525</td>
<td align="center" valign="top">16.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6&#x02013;8</td>
<td align="center" valign="top">Thailand</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Akman et al. (<xref ref-type="bibr" rid="B230">230</xref>)</td>
<td align="center" valign="top">60</td>
<td align="center" valign="top">13.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4</td>
<td align="center" valign="top" rowspan="19">Turkey</td>
</tr>
<tr>
<td align="left" valign="top">Alkar and Gen&#x000E7;&#x000F6;z (<xref ref-type="bibr" rid="B231">231</xref>)</td>
<td align="center" valign="top">151</td>
<td align="center" valign="top">74.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Aydin et al. (<xref ref-type="bibr" rid="B232">232</xref>)</td>
<td align="center" valign="top">728</td>
<td align="center" valign="top">34.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">0&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Aydin et al.(<xref ref-type="bibr" rid="B233">233</xref>)</td>
<td align="center" valign="top">341</td>
<td align="center" valign="top">35.8</td>
<td align="center" valign="top">12.5</td>
<td align="center" valign="top">0&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Ayvaz et al. (<xref ref-type="bibr" rid="B234">234</xref>)</td>
<td align="center" valign="top">152</td>
<td align="center" valign="top">21.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Bugdayci et al. (<xref ref-type="bibr" rid="B235">235</xref>)</td>
<td align="center" valign="top">1,447</td>
<td align="center" valign="top">37.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">0&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Danaci et al. (<xref ref-type="bibr" rid="B236">236</xref>)</td>
<td align="center" valign="top">257</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Dindar and Erdogan (<xref ref-type="bibr" rid="B237">237</xref>)</td>
<td align="center" valign="top">679</td>
<td align="center" valign="top">32.7</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">8&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Ege et al. (<xref ref-type="bibr" rid="B238">238</xref>)</td>
<td align="center" valign="top">364</td>
<td align="center" valign="top">33.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;48</td>
</tr>
<tr>
<td align="left" valign="top">Ekuklu et al. (<xref ref-type="bibr" rid="B239">239</xref>)</td>
<td align="center" valign="top">178</td>
<td align="center" valign="top">40.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Goker et al. (<xref ref-type="bibr" rid="B240">240</xref>)</td>
<td align="center" valign="top">318</td>
<td align="center" valign="top">31.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Gulseren et al. (<xref ref-type="bibr" rid="B241">241</xref>)</td>
<td align="center" valign="top">125</td>
<td align="center" valign="top">13.6</td>
<td align="center" valign="top"/>
<td align="center" valign="top">5&#x02013;26</td>
</tr>
<tr>
<td align="left" valign="top">Inandi et al. (<xref ref-type="bibr" rid="B242">242</xref>)</td>
<td align="center" valign="top">2,514</td>
<td align="center" valign="top">27.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Inandi et al. (<xref ref-type="bibr" rid="B243">243</xref>)</td>
<td align="center" valign="top">1,350</td>
<td align="center" valign="top">31.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Kirpinar et al. (<xref ref-type="bibr" rid="B244">244</xref>)</td>
<td align="center" valign="top">479</td>
<td align="center" valign="top">15.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Orhon et al. (<xref ref-type="bibr" rid="B245">245</xref>)</td>
<td align="center" valign="top">103</td>
<td align="center" valign="top">27.2</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Po&#x000E7;an et al. (<xref ref-type="bibr" rid="B246">246</xref>)</td>
<td align="center" valign="top">187</td>
<td align="center" valign="top">28.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Tezel and G&#x000F6;z&#x000FC;m (<xref ref-type="bibr" rid="B247">247</xref>)</td>
<td align="center" valign="top">567</td>
<td align="center" valign="top">12.9</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Yagmur and Ulukoca (<xref ref-type="bibr" rid="B248">248</xref>)</td>
<td align="center" valign="top">785</td>
<td align="center" valign="top">21.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Ghubash and Abou-Saleh (<xref ref-type="bibr" rid="B249">249</xref>)</td>
<td align="center" valign="top">94</td>
<td align="center" valign="top">18.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1</td>
<td align="center" valign="top" rowspan="3">United Arab Emirates</td>
</tr>
<tr>
<td align="left" valign="top">Green et al. (<xref ref-type="bibr" rid="B250">250</xref>)</td>
<td align="center" valign="top">86</td>
<td align="center" valign="top">39.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">12&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Hamdan and Tamim (<xref ref-type="bibr" rid="B251">251</xref>)</td>
<td align="center" valign="top">137</td>
<td align="center" valign="top">16.8</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Brugha et al. (<xref ref-type="bibr" rid="B252">252</xref>)</td>
<td align="center" valign="top">190</td>
<td align="center" valign="top">17.4</td>
<td align="center" valign="top">11</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top" rowspan="16">United Kingdom</td>
</tr>
<tr>
<td align="left" valign="top">Cooper et al. (<xref ref-type="bibr" rid="B253">253</xref>)</td>
<td align="center" valign="top">5,124</td>
<td align="center" valign="top">31.8</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Edge et al. (<xref ref-type="bibr" rid="B254">254</xref>)</td>
<td align="center" valign="top">301</td>
<td align="center" valign="top">32.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Evans et al. (<xref ref-type="bibr" rid="B255">255</xref>)</td>
<td align="center" valign="top">9,028</td>
<td align="center" valign="top">9.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Hearn et al. (<xref ref-type="bibr" rid="B256">256</xref>)</td>
<td align="center" valign="top">176</td>
<td align="center" valign="top">17.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">7</td>
</tr>
<tr>
<td align="left" valign="top">Heron et al. (<xref ref-type="bibr" rid="B257">257</xref>)</td>
<td align="center" valign="top">207</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top">Honey et al. (<xref ref-type="bibr" rid="B258">258</xref>)</td>
<td align="center" valign="top">223</td>
<td align="center" valign="top">17.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Huang and Mathers (<xref ref-type="bibr" rid="B224">224</xref>)</td>
<td align="center" valign="top">50</td>
<td align="center" valign="top">18.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Matijasevich et al. (<xref ref-type="bibr" rid="B61">61</xref>)</td>
<td align="center" valign="top">13,798</td>
<td align="center" valign="top">9.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Morrell et al. (<xref ref-type="bibr" rid="B259">259</xref>)</td>
<td align="center" valign="top">3,449</td>
<td align="center" valign="top">17.3</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">O&#x02019;Higgins et al. (<xref ref-type="bibr" rid="B260">260</xref>)</td>
<td align="center" valign="top">2,048</td>
<td align="center" valign="top">13.9</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Ramchandani et al. (<xref ref-type="bibr" rid="B261">261</xref>)</td>
<td align="center" valign="top">11,833</td>
<td align="center" valign="top">10.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Shelton and Herrick (<xref ref-type="bibr" rid="B262">262</xref>)</td>
<td align="center" valign="top">394</td>
<td align="center" valign="top">24.4</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Thompson et al. (<xref ref-type="bibr" rid="B263">263</xref>)</td>
<td align="center" valign="top">149</td>
<td align="center" valign="top">18.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Thorpe et al. (<xref ref-type="bibr" rid="B107">107</xref>)</td>
<td align="center" valign="top">101</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Warner et al. (<xref ref-type="bibr" rid="B264">264</xref>)</td>
<td align="center" valign="top">2,375</td>
<td align="center" valign="top">11.8</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">6&#x02013;8</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Abbasi et al. (<xref ref-type="bibr" rid="B265">265</xref>)</td>
<td align="center" valign="top">2,972</td>
<td align="center" valign="top">5.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4</td>
<td align="center" valign="top" rowspan="42">United States of America</td>
</tr>
<tr>
<td align="left" valign="top">Affonso et al. (<xref ref-type="bibr" rid="B29">29</xref>)</td>
<td align="center" valign="top">119</td>
<td align="center" valign="top">34.1</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Beck and Gable (<xref ref-type="bibr" rid="B266">266</xref>)</td>
<td align="center" valign="top">150</td>
<td align="center" valign="top">14.6</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">2&#x02013;12</td>
</tr>
<tr>
<td align="left" valign="top">Birkeland et al. (<xref ref-type="bibr" rid="B267">267</xref>)</td>
<td align="center" valign="top">149</td>
<td align="center" valign="top">29.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Certain et al. (<xref ref-type="bibr" rid="B268">268</xref>)</td>
<td align="center" valign="top">1,519</td>
<td align="center" valign="top">10.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top">Chaudron et al. (<xref ref-type="bibr" rid="B269">269</xref>)</td>
<td align="center" valign="top">60</td>
<td align="center" valign="top">27.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">0&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Dagher and Shenassa (<xref ref-type="bibr" rid="B270">270</xref>)</td>
<td align="center" valign="top">526</td>
<td align="center" valign="top">6.5</td>
<td align="center" valign="top"/>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Dagher et al. (<xref ref-type="bibr" rid="B271">271</xref>)</td>
<td align="center" valign="top">638</td>
<td align="center" valign="top">4.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">11</td>
</tr>
<tr>
<td align="left" valign="top">Demissie et al. (<xref ref-type="bibr" rid="B272">272</xref>)</td>
<td align="center" valign="top">652</td>
<td align="center" valign="top">7.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Doering Runquist et al. (<xref ref-type="bibr" rid="B273">273</xref>)</td>
<td align="center" valign="top">43</td>
<td align="center" valign="top">24.3</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">4&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Eisenach et al. (<xref ref-type="bibr" rid="B274">274</xref>)</td>
<td align="center" valign="top">939</td>
<td align="center" valign="top">11.2</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Gaffney et al. (<xref ref-type="bibr" rid="B275">275</xref>)</td>
<td align="center" valign="top">1,447</td>
<td align="center" valign="top">24.1</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Georgiopoulos et al. (<xref ref-type="bibr" rid="B276">276</xref>)</td>
<td align="center" valign="top">909</td>
<td align="center" valign="top">11.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Glynn and Sandman (<xref ref-type="bibr" rid="B277">277</xref>)</td>
<td align="center" valign="top">170</td>
<td align="center" valign="top">20.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">12</td>
</tr>
<tr>
<td align="left" valign="top">Gorman et al. (<xref ref-type="bibr" rid="B143">143</xref>)</td>
<td align="center" valign="top">41</td>
<td align="center" valign="top">5.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Hahn-Holbrook et al. (<xref ref-type="bibr" rid="B278">278</xref>)</td>
<td align="center" valign="top">200</td>
<td align="center" valign="top">20.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">13</td>
</tr>
<tr>
<td align="left" valign="top">Herring et al. (<xref ref-type="bibr" rid="B279">279</xref>)</td>
<td align="center" valign="top">850</td>
<td align="center" valign="top">4.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Horowitz (<xref ref-type="bibr" rid="B280">280</xref>)</td>
<td align="center" valign="top">1,071</td>
<td align="center" valign="top">19.7</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">2&#x02013;4</td>
</tr>
<tr>
<td align="left" valign="top">Horowitz et al. (<xref ref-type="bibr" rid="B281">281</xref>)</td>
<td align="center" valign="top">5,169</td>
<td align="center" valign="top">13.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top">Howell et al. (<xref ref-type="bibr" rid="B282">282</xref>)</td>
<td align="center" valign="top">242</td>
<td align="center" valign="top">14.1</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Howell et al. (<xref ref-type="bibr" rid="B283">283</xref>)</td>
<td align="center" valign="top">251</td>
<td align="center" valign="top">5.5</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">3&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Hunker et al. (<xref ref-type="bibr" rid="B284">284</xref>)</td>
<td align="center" valign="top">123</td>
<td align="center" valign="top">21.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top">Kim et al. (<xref ref-type="bibr" rid="B285">285</xref>)</td>
<td align="center" valign="top">324</td>
<td align="center" valign="top">17.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">1</td>
</tr>
<tr>
<td align="left" valign="top">Kuo et al. (<xref ref-type="bibr" rid="B286">286</xref>)</td>
<td align="center" valign="top">139</td>
<td align="center" valign="top">25.4</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">1&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">McGrath et al. (<xref ref-type="bibr" rid="B287">287</xref>)</td>
<td align="center" valign="top">114</td>
<td align="center" valign="top">13.1</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">9&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Mercier et al. (<xref ref-type="bibr" rid="B288">288</xref>)</td>
<td align="center" valign="top">688</td>
<td align="center" valign="top">6.7</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">12&#x02013;52</td>
</tr>
<tr>
<td align="left" valign="top">Miller et al. (<xref ref-type="bibr" rid="B46">46</xref>)</td>
<td align="center" valign="top">280</td>
<td align="center" valign="top">8.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">0&#x02013;16</td>
</tr>
<tr>
<td align="left" valign="top">Morris-Rush et al. (<xref ref-type="bibr" rid="B289">289</xref>)</td>
<td align="center" valign="top">121</td>
<td align="center" valign="top">22.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Mosack and Shore (<xref ref-type="bibr" rid="B290">290</xref>)</td>
<td align="center" valign="top">98</td>
<td align="center" valign="top">14.3</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Mott et al. (<xref ref-type="bibr" rid="B291">291</xref>)</td>
<td align="center" valign="top">147</td>
<td align="center" valign="top">7.5</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">52</td>
</tr>
<tr>
<td align="left" valign="top">Murphy et al. (<xref ref-type="bibr" rid="B292">292</xref>)</td>
<td align="center" valign="top">97</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Park et al. (<xref ref-type="bibr" rid="B293">293</xref>)</td>
<td align="center" valign="top">25</td>
<td align="center" valign="top">12.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">2&#x02013;14</td>
</tr>
<tr>
<td align="left" valign="top">Paul et al. (<xref ref-type="bibr" rid="B294">294</xref>)</td>
<td align="center" valign="top">1,123</td>
<td align="center" valign="top">4.2</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">1&#x02013;24</td>
</tr>
<tr>
<td align="left" valign="top">Reighard and Evans (<xref ref-type="bibr" rid="B295">295</xref>)</td>
<td align="center" valign="top">181</td>
<td align="center" valign="top">19.9</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top"/>
</tr>
<tr>
<td align="left" valign="top">Rich-Edwards et al. (<xref ref-type="bibr" rid="B296">296</xref>)</td>
<td align="center" valign="top">1,278</td>
<td align="center" valign="top">8.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Roy et al. (<xref ref-type="bibr" rid="B297">297</xref>)</td>
<td align="center" valign="top">185</td>
<td align="center" valign="top">17.4</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Schaper et al. (<xref ref-type="bibr" rid="B298">298</xref>)</td>
<td align="center" valign="top">287</td>
<td align="center" valign="top">7.0</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">24</td>
</tr>
<tr>
<td align="left" valign="top">Silverman and Loudon (<xref ref-type="bibr" rid="B299">299</xref>)</td>
<td align="center" valign="top">439</td>
<td align="center" valign="top">21.4</td>
<td align="center" valign="top">9</td>
<td align="center" valign="top">6</td>
</tr>
<tr>
<td align="left" valign="top">Watkins et al. (<xref ref-type="bibr" rid="B300">300</xref>)</td>
<td align="center" valign="top">2,586</td>
<td align="center" valign="top">8.6</td>
<td align="center" valign="top">13</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Wisner et al. (<xref ref-type="bibr" rid="B301">301</xref>)</td>
<td align="center" valign="top">10,000</td>
<td align="center" valign="top">14.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">4&#x02013;6</td>
</tr>
<tr>
<td align="left" valign="top">Yim et al. (<xref ref-type="bibr" rid="B302">302</xref>)</td>
<td align="center" valign="top">100</td>
<td align="center" valign="top">22.0</td>
<td align="center" valign="top">10</td>
<td align="center" valign="top">8</td>
</tr>
<tr>
<td align="left" valign="top">Yonkers et al. (<xref ref-type="bibr" rid="B303">303</xref>)</td>
<td align="center" valign="top">802</td>
<td align="center" valign="top">16.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">4</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Chibanda et al. (<xref ref-type="bibr" rid="B304">304</xref>)</td>
<td align="center" valign="top">210</td>
<td align="center" valign="top">35.5</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6&#x02013;7</td>
<td align="center" valign="top">Zimbabwe</td>
</tr>
<tr>
<td align="left" valign="top" colspan="6"><hr/></td>
</tr>
<tr>
<td align="left" valign="top">Fisher et al. (<xref ref-type="bibr" rid="B305">305</xref>)</td>
<td align="center" valign="top">506</td>
<td align="center" valign="top">33.0</td>
<td align="center" valign="top">12</td>
<td align="center" valign="top">6</td>
<td align="center" valign="top">Vietnam</td>
</tr>
</tbody>
</table>
</table-wrap>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption><p>Funnel plot <bold>(A)</bold> and Doi plot <bold>(B)</bold> of postpartum depression (PPD) prevalence as a function of prevalence estimate SE.</p></caption>
<graphic xlink:href="fpsyt-08-00248-g002.tif"/>
</fig>
</sec>
<sec id="S3-2">
<title>Meta-Regression of Between-Study Variation</title>
<p>Studies that used lower cutoffs of the EPDS reported significantly higher prevalence (Coef.&#x02009;&#x0003D;&#x02009;&#x02212;1.44, SE&#x02009;&#x0003D;&#x02009;0.455, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.002; CI:&#x02009;&#x02212;2.333 to &#x02212;0.542, <italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;3.08%). Studies that measured PPD later postpartum tended to report slightly lower levels of PPD (Coef.&#x02009;&#x0003D;&#x02009;&#x02212;0.373, SE&#x02009;&#x0003D;&#x02009;0.109, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.001, 95% CI:&#x02009;&#x02212;0.587 to &#x02212;0.159, <italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;3.65%). No other methodological variables predicted between-study variation in PPD. Together timing of PPD assessment and cutoff used accounted for 5.21% of the variance in PPD prevalence between studies [<italic>F</italic>(2, 293)&#x02009;&#x0003D;&#x02009;6.44, <italic>p</italic>&#x02009;&#x0003C;&#x02009;0.002].</p>
</sec>
<sec id="S3-3">
<title>Meta-Analyses of National PPD Prevalence</title>
<p>See Figure <xref ref-type="fig" rid="F3">3</xref> for meta-analytically derived estimates of PPD prevalence in 40 countries. National sample sizes ranged from 244 to 65,634 women (M&#x02009;&#x0003D;&#x02009;7,229.76; SD&#x02009;&#x0003D;&#x02009;13,502.69). National estimates of PPD ranged from 3.1% in Singapore to 37.7% in Chile. Meta-analysis suggested that there was significant heterogeneity in PPD prevalence between nations (<italic>Q</italic>&#x02009;&#x0003D;&#x02009;3,489.09, <italic>p</italic>&#x02009;&#x0003C;&#x02009;0.001, <italic>I</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;99%).</p>
<fig id="F3" position="float">
<label>Figure 3</label>
<caption><p>Meta-analytically derived postpartum depression prevalence in 40 Countries.</p></caption>
<graphic xlink:href="fpsyt-08-00248-g003.tif"/>
</fig>
</sec>
<sec id="S3-4">
<title>Meta-Regression of Predictors of Cross-National Variation</title>
<sec id="S3-4-1">
<title>Methodological Predictors</title>
<p>None of the methodological variables predicted cross-national variation in PPD prevalence (all <italic>p</italic>s&#x02009;&#x0003E;&#x02009;0.15). Therefore, no methodological variables were included as covariates in subsequent models.</p>
</sec>
<sec id="S3-4-2">
<title>Economic and Policy Predictors</title>
<p>GINI index explained 41% of the cross-national variation in PPD prevalence. Nations with higher wealth inequality had higher levels of PPD (<italic>N</italic>&#x02009;&#x0003D;&#x02009;38; Coef.&#x02009;&#x0003D;&#x02009;0.039, SE&#x02009;&#x0003D;&#x02009;0.009, <italic>p</italic>&#x02009;&#x0003C;&#x02009;0.000, CI: 0.020 to 0.058) (see Figure <xref ref-type="fig" rid="F4">4</xref>A). GDP per capita was also inversely related to PPD prevalence (<italic>N</italic>&#x02009;&#x0003D;&#x02009;39; Coef.&#x02009;&#x0003D;&#x02009;&#x02212;0.033, SE&#x02009;&#x0003D;&#x02009;0.009, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.002, CI:&#x02009;&#x02212;0.053 to&#x02009;&#x02212;0.014, <italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;30.4%). However, when GDP per capital and GINI index were modeled together, GINI index remained statistically significant while GDP per capita did not. In addition, countries with higher percentages of young women who were working &#x02265;40&#x02009;h a week had higher PPD prevalence (<italic>N</italic>&#x02009;&#x0003D;&#x02009;24; Coef.&#x02009;&#x0003D;&#x02009;0.038, SE&#x02009;&#x0003D;&#x02009;0.013, <italic>p</italic>&#x02009;&#x0003C;&#x02009;.01, CI:&#x02009;0.012 to 0.065, <italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;30.9%; see Figure <xref ref-type="fig" rid="F4">4</xref>B). National paid and unpaid maternity leave policies did not predict PPD prevalence (<italic>p</italic>s&#x02009;&#x0003E;&#x02009;0.60). Together, economic predictors (GINI index, GDP per capita, and women working &#x0003E;40&#x02009;h per week) accounted for 73.1% of the cross-national variation in PPD prevalence, although GINI index was the only unique economic predictor in a multivariate model.</p>
<fig id="F4" position="float">
<label>Figure 4</label>
<caption><p><bold>(A&#x02013;D)</bold> Bubble plots are presented showing the associations between GINI index <bold>(A)</bold>, % of women aged 25&#x02013;30 working &#x02265;40&#x02009;h a week <bold>(B)</bold>, lifetime risk of maternal death <bold>(C)</bold>, and total fertility rate <bold>(D)</bold> with national postpartum depression (PPD) prevalence. Countries with larger bubbles had larger sample sizes and were weighted accordingly in meta-regression models.</p></caption>
<graphic xlink:href="fpsyt-08-00248-g004.tif"/>
</fig>
</sec>
<sec id="S3-4-3">
<title>Health Predictors</title>
<p>Rates of maternal mortality and total fertility in Nigeria were more than 4 SDs above the mean, therefore Nigeria was excluded from analyses involving these factors. Higher prevalence of PPD was reported in countries with higher risk of maternal or infant mortality (maternal mortality: <italic>N</italic>&#x02009;&#x0003D;&#x02009;36; Coeff.&#x02009;&#x0003D;&#x02009;0.045, SE&#x02009;&#x0003D;&#x02009;0.019, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.024, CI &#x0003D; 0.006 to 0.085), <italic>R</italic><sup>2</sup> change&#x02009;&#x0003D;&#x02009;18.73%, see Figure <xref ref-type="fig" rid="F4">4</xref>C; infant mortality: <italic>N</italic>&#x02009;&#x0003D;&#x02009;36; Coeff.&#x02009;&#x0003D;&#x02009;0.039, SE&#x02009;&#x0003D;&#x02009;0.018, <italic>p</italic>&#x02009;&#x0003D;&#x02009;<italic>0.034</italic>, CI: 0.003 to 0.074; <italic>R</italic><sup>2</sup> change&#x02009;&#x0003D;&#x02009;15.56%). There were also statistical trends suggesting that higher national PPD prevalence was associated with higher total fertility rates (<italic>N</italic>&#x02009;&#x0003D;&#x02009;36; Coeff.&#x02009;&#x0003D;&#x02009;0.040, SE&#x02009;&#x0003D;&#x02009;0.024, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.102, CI:&#x02009;&#x02212;0.008 to 0.088; <italic>R</italic><sup>2</sup> change&#x02009;&#x0003D;&#x02009;6.33%, see Figure <xref ref-type="fig" rid="F4">4</xref>D) and higher percentages of infants born low birth weight (<italic>N</italic>&#x02009;&#x0003D;&#x02009;36; Coeff.&#x02009;&#x0003D;&#x02009;0.023, SE&#x02009;&#x0003D;&#x02009;0.014, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.094, CI:&#x02009;&#x02212;0.004 to 0.051; <italic>R</italic><sup>2</sup> change&#x02009;&#x0003D;&#x02009;9.99%). National cesarean rates did not predict PPD prevalence. Together, these health factors predicted 26.03% of the variance in PPD prevalence, although maternal mortality rate was the only unique predictor in multivariate models when all health variables were included.</p>
</sec>
<sec id="S3-4-4">
<title>Sociodemographic Predictors</title>
<p>The percentages of infants born outside of marriage, living in single parent homes or in urbanized areas did not predict cross-national PPD prevalence.</p>
<p>In sum, economic and health variables explained 73.87% percent of the cross-national variation in PPD [<italic>N</italic>&#x02009;&#x0003D;&#x02009;24; <italic>F</italic>(3, 20)&#x02009;&#x0003D;&#x02009;13.27, <italic>p</italic>&#x02009;&#x0003C;&#x02009;0.001]. Notably, GINI index was the only significant independent predictor of cross-national PPD incidence when all health and economic predictors were included together in the model.</p>
</sec>
</sec>
</sec>
<sec id="S4" sec-type="discussion">
<title>Discussion</title>
<p>In the largest meta-analysis and meta-regression of PPD to date, the global prevalence of PPD was found to be approximately 17.7% (95% CI: 16.6&#x02013;18.8%). Adjusting for the recommended cutoffs provided by the EPDS for possible (&#x02265;10) and probable depression (&#x02265;13) yielded prevalence estimates of 21.3 and 16.7%, respectively. These estimates are significantly higher than the widely cited prevalence of 13% (95% CI: 12.3&#x02013;13.4%), derived from a meta-analysis of studies from developed countries (<xref ref-type="bibr" rid="B6">6</xref>). Our estimate is more similar to the 19% prevalence for PPD derived from studies of relatively low- and middle-income countries (<xref ref-type="bibr" rid="B7">7</xref>). We found some evidence of publication bias wherein larger studies reported lower PPD prevalence (<italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;0.8%). However, this effect was small and most likely a byproduct of the fact that countries with more wealth inequality tend to produce studies with smaller sample sizes and wealth inequality (GINI index) between nations predicted 41% of the cross-national variation in PPD in this meta-analysis and meta-regression.</p>
<p>The current meta-analysis also revealed large disparities in PPD prevalence across nations. The countries with the highest rates of PPD were Chile (38%, 95% CI: 35&#x02013;41%), South Africa (37%; 95% CI: 31&#x02013;42%), Hong Kong (30%, CI: 28&#x02013;31%), and Turkey (28%, CI: 27&#x02013;29%). In contrast, countries with the lowest rates included Singapore (3%; 95% CI: 2&#x02013;5%), Nepal (7%; 95% CI: 5&#x02013;10%), the Netherlands (8%; 95% CI: 7&#x02013;9%), and Switzerland (11%; 95% CI: 7&#x02013;13%). Surprisingly, these national differences in PPD prevalence could not be explained by methodological conventions used in different counties, for example, the typical EPDS cutoff used, sample size, or the timing of PPD assessment. Instead, the vast majority (73%) of the cross-national variation in PPD prevalence could be explained by economic and health disparities between nations.</p>
<p>Notably, national disparities in PPD appear to exist even among countries that fall within similar economic strata. For example, Chile evinced the highest rates of PPD whereas another high-income nation, the Netherlands, had among the lowest. As many scholars have pointed out (<xref ref-type="bibr" rid="B306">306</xref>&#x02013;<xref ref-type="bibr" rid="B308">308</xref>), aggregate wealth metrics like GDP give only a very limited picture of the circumstances of large portions of the population. Instead, we found that wealth disparities (i.e., GINI coefficients) was the most robust predictor of cross-national variation in PPD. Countries with higher GINI coefficients have a greater proportion of citizens living in abject poverty, which is a potent predictor of many mental and physical health problems (<xref ref-type="bibr" rid="B309">309</xref>). As previous investigators have also noted, living below the material standards of one&#x02019;s society equates to possessing low social status&#x02014;regardless of objective income&#x02014;which can limit access to less tangible resources like education, opportunity, and security (<xref ref-type="bibr" rid="B308">308</xref>). Loss of these forms of social capital is thought to contribute to family dysfunction, health problems, and mood disorders (<xref ref-type="bibr" rid="B28">28</xref>).</p>
<p>Relatedly, countries with higher rates of wealth inequality in this meta-analysis also tended to have a higher percentage of women of childbearing age working full-time (Coef.&#x02009;&#x0003D;&#x02009;0.553, SE&#x02009;&#x0003D;&#x02009;0.126, <italic>p</italic>&#x02009;&#x0003D;&#x02009;0.001, CI:&#x02009;&#x0003D;&#x02009;0.250 to 856, <italic>R</italic><sup>2</sup>&#x02009;&#x0003D;&#x02009;36.9%). This fact may partially explain why countries in which higher proportions of women of childbearing age work full-time have a higher prevalence of PPD. Working full-time while caring for young children can place multiple demands on new mothers (<xref ref-type="bibr" rid="B310">310</xref>, <xref ref-type="bibr" rid="B311">311</xref>), causing stress and family discord linked to PPD. These findings militate for PPD intervention efforts focusing on providing support for working mothers.</p>
<p>Our finding that maternal mortality predicts 19% of the cross-national variation in PPD prevalence can be interpreted in several ways. First, suicide linked to mental illness is a major cause of maternal mortality in many countries (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>). However, maternal mortality is also a reliable proxy of poor access to medical care, consistent with our finding that higher rates of infant mortality and low birth weight also predicted higher national PPD prevalence. The relationship between maternal mortality and PPD is likely bidirectional, with PPD driving maternal mortality rates and poor healthcare driving both maternal mortality and PPD risk. Therefore, efforts to improve either of these outcomes are likely to evince spillover benefits improving the other. Relatedly, high total fertility rates predicted elevated PPD prevalence, suggesting that improved access to contraception associated with healthcare services may also reduce national PPD prevalence.</p>
</sec>
<sec id="S5">
<title>Limitations</title>
<p>Several methodological limitations should be considered when interpreting the results of this meta-analysis and meta-regression. First, clinical interviews are the gold standard for PPD diagnosis, whereas our analysis focused on a widely used self-report measure. Self-report measures tend to yield higher estimates of PPD than clinical interviews, therefore, our estimates are likely higher than if we had focused on interview methods (<xref ref-type="bibr" rid="B6">6</xref>). However, given the serious consequences of PPD, we felt it was better to potentially overestimate than to underestimate national prevalence. Second, several countries had few studies (e.g., Finland, Mexico, and Nepal), rendering those national estimates less reliable relative to countries where the bulk of PPD research has been done (e.g., the United States, the United Kingdom, and Australia). Finally, many potential predictors of cross-national PPD prevalence were beyond the scope of this study ranging from degree of cultural collectivism to rates of vitamin D deficiency (<xref ref-type="bibr" rid="B311">311</xref>&#x02013;<xref ref-type="bibr" rid="B313">313</xref>). We hope that the data set provided in this study will allow future researchers to uncover additional structural, cultural and health predictors of cross-national variation in PPD prevalence.</p>
</sec>
<sec id="S6">
<title>Conclusion</title>
<p>In sum, our findings reveal that the global prevalence of PPD is both higher and more variable than previously thought, and that wealth inequality, maternal-child health indexes, and employment patterns explain most of the cross-national variation. Creating meaningful improvements in these areas presents enormous social challenges, yet the potential benefits of reducing PPD for mothers, families, and infants are equally great.</p>
</sec>
<sec id="S7" sec-type="author-contributor">
<title>Author Contributions</title>
<p>JH-H conceptualized the research questions, conducted the analysis, wrote the paper, and approved this manuscript. TC-H and IA helped to compile the data set, write the manuscript, and approved this manuscript.</p>
</sec>
<sec id="S8">
<title>Conflict of Interest Statement</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
</body>
<back>
<ack>
<p>The authors would like to thank Taylor Delaney, Lilly Murphy, Holly Rankin, Ian Nel, and Nicole Wright for assistance in compiling the data set. The authors would also like to acknowledge the work of Halbreich U, Karkun S, Norhayati MN, Hazlina NN, Asrenee AR, Emilin WW, Fisher A, Cabral de Mello C, Patel V, Rahman A, Tran T, Holton S, and Holmes W for creating the careful systematic reviews on which this work heavily relied.</p>
</ack>
<sec id="S9" sec-type="supplementary-material">
<title>Supplementary Material</title>
<p>The Supplementary Material for this article can be found online at <uri xlink:href="https://www.frontiersin.org/articles/10.3389/fpsyt.2017.00248/full&#x00023;supplementary-material">https://www.frontiersin.org/articles/10.3389/fpsyt.2017.00248/full&#x00023;supplementary-material</uri>.</p>
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<supplementary-material xlink:href="Image_1.jpg" id="SM2" mimetype="applicationn/jpg" xmlns:xlink="http://www.w3.org/1999/xlink"/>
</sec>
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</ref-list>
<app-group>
<app id="app1">
<title>Appendix</title>
<sec id="S10-1">
<title>Boolean Search Information</title>
<p>CINAHL</p>
<p>Boolean search that yields 142 records:</p>
<p>(IN edinburgh postnatal depression scale) AND (AB (postpartum depression OR postnatal depression)) AND (AB (incidence OR prevalence))</p>
<p>With the additional limiters:
<list list-type="simple">
<list-item><label>(1)</label> <p>Narrow to 1985&#x02013;2015</p></list-item>
<list-item><label>(2)</label> <p>Narrow to English articles only</p></list-item>
<list-item><label>(3)</label> <p>Narrow to Humans only</p></list-item>
<list-item><label>(4)</label> <p>Narrow to Females only</p></list-item>
</list></p>
<p>Permanent Link: <uri xlink:href="http://libproxy.chapman.edu/login?url&#x0003D;https://search.ebscohost.com/login.aspx?direct&#x0003D;true&#x00026;AuthType&#x0003D;ip,uid,cookie,url&#x00026;db&#x0003D;rzh&#x00026;bquery&#x0003D;(IN&#x0002B;edinburgh&#x0002B;postnatal&#x0002B;depression&#x0002B;scale)&#x0002B;AND&#x0002B;(AB&#x0002B;(postpartum&#x0002B;depression&#x0002B;OR&#x0002B;postnatal&#x0002B;depression))&#x0002B;AND&#x0002B;(AB&#x0002B;(incidence&#x0002B;OR&#x0002B;prevalence))&#x00026;cli0&#x0003D;DT1&#x00026;clv0&#x0003D;198501-201512&#x00026;cli1&#x0003D;CT3&#x00026;clv1&#x0003D;Female&#x00026;cli2&#x0003D;LA99&#x00026;clv2&#x0003D;eng&#x00026;type&#x0003D;1&#x00026;site&#x0003D;ehost-live">http://libproxy.chapman.edu/login?url&#x0003D;https://search.ebscohost.com/login.aspx?direct&#x0003D;true&#x00026;AuthType&#x0003D;ip,uid,cookie,url&#x00026;db&#x0003D;rzh&#x00026;bquery&#x0003D;(IN&#x0002B;edinburgh&#x0002B;postnatal&#x0002B;depression&#x0002B;scale)&#x0002B;AND&#x0002B;(AB&#x0002B;(postpartum&#x0002B;depression&#x0002B;OR&#x0002B;postnatal&#x0002B;depression))&#x0002B;AND&#x0002B;(AB&#x0002B;(incidence&#x0002B;OR&#x0002B;prevalence))&#x00026;cli0&#x0003D;DT1&#x00026;clv0&#x0003D;198501-201512&#x00026;cli1&#x0003D;CT3&#x00026;clv1&#x0003D;Female&#x00026;cli2&#x0003D;LA99&#x00026;clv2&#x0003D;eng&#x00026;type&#x0003D;1&#x00026;site&#x0003D;ehost-live</uri></p>
<p>PsychInfo</p>
<p>Boolean search that yields 236 records:</p>
<p>AB (incidence or prevalence) AND AB (postnatal depression or postpartum depression) AND TM edinburgh postnatal depression scale</p>
<p>With the additional limiters:
<list list-type="simple">
<list-item><label>(1)</label> <p>Narrow to 1985&#x02013;2015</p></list-item>
<list-item><label>(2)</label> <p>Narrow to English articles only</p></list-item>
<list-item><label>(3)</label> <p>Narrow to females only</p></list-item>
</list></p>
<p><uri xlink:href="http://libproxy.chapman.edu/login?url&#x0003D;https://search.ebscohost.com/login.aspx?direct&#x0003D;true&#x00026;AuthType&#x0003D;ip,uid,cookie,url&#x00026;db&#x0003D;psyh&#x00026;bquery&#x0003D;(AB&#x0002B;(incidence&#x0002B;OR&#x0002B;prevalence))&#x0002B;AND&#x0002B;(AB&#x0002B;(postnatal&#x0002B;depression&#x0002B;OR&#x0002B;postpartum&#x0002B;depression))&#x0002B;AND&#x0002B;(TM&#x0002B;edinburgh&#x0002B;postnatal&#x0002B;depression&#x0002B;scale)&#x00026;cli0&#x0003D;PY&#x00026;clv0&#x0003D;198501-201512&#x00026;cli1&#x0003D;LA1&#x00026;clv1&#x0003D;Y&#x00026;cli2&#x0003D;PO2&#x00026;clv2&#x0003D;Female&#x00026;type&#x0003D;1&#x00026;site&#x0003D;ehost-live">http://libproxy.chapman.edu/login?url&#x0003D;https://search.ebscohost.com/login.aspx?direct&#x0003D;true&#x00026;AuthType&#x0003D;ip,uid,cookie,url&#x00026;db&#x0003D;psyh&#x00026;bquery&#x0003D;(AB&#x0002B;(incidence&#x0002B;OR&#x0002B;prevalence))&#x0002B;AND&#x0002B;(AB&#x0002B;(postnatal&#x0002B;depression&#x0002B;OR&#x0002B;postpartum&#x0002B;depression))&#x0002B;AND&#x0002B;(TM&#x0002B;edinburgh&#x0002B;postnatal&#x0002B;depression&#x0002B;scale)&#x00026;cli0&#x0003D;PY&#x00026;clv0&#x0003D;198501-201512&#x00026;cli1&#x0003D;LA1&#x00026;clv1&#x0003D;Y&#x00026;cli2&#x0003D;PO2&#x00026;clv2&#x0003D;Female&#x00026;type&#x0003D;1&#x00026;site&#x0003D;ehost-live</uri></p>
<p>PubMed</p>
<p>Boolean search yields 338 records:</p>
<p>((&#x0201C;postpartum depression&#x0201D;[All Fields] OR &#x0201C;postnatal depression&#x0201D;[All Fields]) AND &#x0201C;prevalence&#x0201D;[All Fields]) AND &#x0201C;edinburgh postnatal depression scale&#x0201D;[All Fields] AND ((&#x0201C;1985/01/01&#x0201D;[PDAT]:?&#x0201C;2015/12/31&#x0201D;[PDAT]) AND &#x0201C;humans&#x0201D;[MeSH Terms])</p>
</sec>
</app>
</app-group>
</back>
</article>