<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="review-article">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Psychiatry</journal-id>
<journal-title>Frontiers in Psychiatry</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Psychiatry</abbrev-journal-title>
<issn pub-type="epub">1664-0640</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fpsyt.2013.00086</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Psychiatry</subject>
<subj-group>
<subject>Opinion Article</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Bacchus by Caravaggio as the Visual Diagnosis of Alcohol Use Disorder from the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Haass-Koffler</surname> <given-names>Carolina L.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="author-notes" rid="fn001">&#x0002A;</xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Kenna</surname> <given-names>George A.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University</institution> <country>Providence, RI, USA</country></aff>
<aff id="aff2"><sup>2</sup><institution>Bouv&#x000E9; College of Health Sciences, Northeastern University</institution> <country>Boston, MA, USA</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Psychiatry and Human Behavior, Brown University</institution> <country>Providence, RI, USA</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Lorenzo Leggio, National Institutes of Health, USA</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Antonio Mirijello, Catholic University of Rome, Italy; Lorenzo Leggio, National Institutes of Health, USA</p></fn>
<fn fn-type="corresp" id="fn001"><p>&#x0002A;Correspondence: <email>carolina&#x00040;haasskoffler.net</email></p></fn>
<fn fn-type="other" id="fn002"><p>This article was submitted to Frontiers in Addictive Disorders and Behavioral Dyscontrol, a specialty of Frontiers in Psychiatry.</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>08</day>
<month>08</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="collection">
<year>2013</year>
</pub-date>
<volume>4</volume>
<elocation-id>86</elocation-id>
<history>
<date date-type="received">
<day>23</day>
<month>07</month>
<year>2013</year>
</date>
<date date-type="accepted">
<day>29</day>
<month>07</month>
<year>2013</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2013 Haass-Koffler and Kenna.</copyright-statement>
<copyright-year>2013</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<counts>
<fig-count count="1"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="8"/>
<page-count count="2"/>
<word-count count="1491"/>
</counts>
</article-meta>
</front>
<body>
<p>For his Bacchus (Figure <xref ref-type="fig" rid="F1">1</xref>), Michelangelo Merisi from Caravaggio (1571&#x02013;1610) did not choose a model that resembles the classical idolized God of wine represented in the past. The figure is not the Greek Dionysus, a strongly built, mature male wearing a robe. The figure is not the young Roman Bacchus represented with vine and dripping honey who seems to be free from self-consciousness. Instead, he chose a young boy without refined physical traits. He depicted a vulgar youngster, dressed as Bacchus, who put on a costume in an irreverent manner, waiting to drink the wine in the chalice, collecting the few <italic>scudi</italic> (Roman currency of the day) for modeling in order to run to the tavern at the end of the street for more drinking. Because of Caravaggio&#x00027;s lack of money for hiring models and his love for alcohol, many art historians suggested that the painting is a self-portrait. Furthermore, because the figure holds the chalice containing the red wine with his left hand, it has hypothesized that Caravaggio used the help of a mirror (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>).</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p><bold>Bacchus (1596), Michelangelo Merisi from Caravaggio</bold>. Oil on canvas, 95&#x02009;&#x000D7;&#x02009;85&#x02009;cm, <italic>Galleria degli Uffizi</italic>, Florence, Italy. Image reproduced with permission from the <italic>Soprintendenza Speciale per il Patrimonio Storico Artistico e Etnoantropologico per il Polo Museale</italic>, Florence, Italy.</p></caption>
<graphic xlink:href="fpsyt-04-00086-g001.tif"/>
</fig>
<p>The dangerously inclined chalice with rippling wine, combined with the wine carafe with a very small pedestal, makes for a very wobbly scene. The wine, a Eucharistic symbol, could spill from the chalice held by the model and splatter from the carafe, which contains a small reflection of himself. The entire image gives us the concept of time where, in a moment of instability, a precariously balanced image of life could spiral into chaos.</p>
<p>The basket of fruit, common trait in Caravaggio&#x00027;s paintings, is not just a decoration of beautiful foliage and succulent produce. The painting includes both a collection of savory and decayed fruits, framed by flourishing fresh green and drying yellow-brown leaves. The still life part of this painting embodies the simultaneous presence of health and sickness, life and death. This cycle of life however is not depicted only to represent the transient and inevitable nature of existence that would be depicted the following century in the <italic>vanitas</italic> by Flemish painters. The still life that shares the space with this Bacchus reminds the viewer of the futility of pleasure and the certainty of death, but lacks the symbols of hope and renewal against darkness, which are expressed by the presence of insects. Furthermore, the symbol of power, represented in fine arts by a crown, is in this figure illustrated by a crest of grapes and senescing leaves that reiterate the deterioration of life.</p>
<p>With his depiction of Bacchus, Caravaggio used photo-like realism to deliver an accurate and precise diagnosis of Alcohol Use Disorder (AUD). With the model&#x00027;s features, Caravaggio was able to depict the neurological and psychiatric symptoms of alcoholism. The skin rosacea and dirty fingernails allude to nutritional deficiency and poor personal hygiene. He showed both the impaired fine and gross motor movements; the hand tremor resulted in the undulating wine inside the chalice, and the possibility exists of losing the balance of the model&#x00027;s right elbow and hitting the fragile carafe. The dilated blood vessels showed by the flushed face, swollen eyelids, and red hands, are the physical characteristics of an individual suffering from AUD. In his direct realism, Caravaggio also chose to depict himself in another self-portrait during an illness characterized by strong jaundice (Sick Bacchus, 1594). Caravaggio, probably being an alcoholic himself, was spending a great deal of time in taverns. He had seen chronic alcoholic individuals with jaundice and had witnessed their death (assumed to be from liver failure due to cirrhosis) (<xref ref-type="bibr" rid="B3">3</xref>).</p>
<p>Using the symbolism encoded in the still life, Caravaggio was able to illustrate the psychological characteristics of alcoholic individuals. Caravaggio depicted the decreasing of inhibition and the increasing of seductive behaviors of the model by using eternal life symbolism. The pomegranate is cracked, inferring fall from grace and open to sinful nature. The white and black grapes crowning the head of the model, which signify lewdness and lustful thoughts, are ripened and pungent, while the leaves, symbolizing loss of innocence, are yellowing and drying. There are no butterflies or moths to evoke the idea of rebirth, but just a codling moth entrance hole. This portrait is a sad and gloomy face of life that does not comprise salvation and resurrection.</p>
<p>Many of the revisions in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5, dsm5.org) are intended to provide diagnosis and clinical care support to non-psychiatrists (since primary care physicians are most likely to be the first to assess psychiatric symptoms) (<xref ref-type="bibr" rid="B4">4</xref>). One of the major changes is the merger of the two diagnoses of Alcohol Abuse and Alcohol Dependence into a single diagnosis called Alcohol Use Disorder (AUD). The medical community has perceived the merger of the criteria positively since the DSM-IV term dependence was restricted only to patients experiencing withdrawal during treatment (<xref ref-type="bibr" rid="B5">5</xref>) leaving some patients &#x0201C;diagnostic orphans&#x0201D; (<xref ref-type="bibr" rid="B6">6</xref>). In the DSM-5, those patients are included in the AUD criterion and continue receiving medical treatment as in other psychiatric disorders (<xref ref-type="bibr" rid="B7">7</xref>).</p>
<p>The Bacchus, according to the DSM-IV criteria would not meet the full requirements for an Alcohol Dependence diagnosis because he is not an individual experiencing alcohol withdrawal during treatment and he does not appear to suffer of severe dependence (<xref ref-type="bibr" rid="B8">8</xref>). Furthermore, he probably would not meet the criteria of Alcohol Abuse since as a model, he is performing a job responsibility. Every aspect of the painting, however, suggests that Bacchus is suffering from AUD; the Bacchus would be a &#x0201C;diagnostic orphan.&#x0201D;</p>
<p>Caravaggio challenged society with his controversial and revolutionary art. He developed a realism that forced his contemporaries to see the actual face of alcoholism. That image depicted more than 400 years ago is today the pictorial representation of AUD and patients with the updated DSM-5 criteria will obtain a diagnosis and will receive treatment.</p>
</body>
<back>
<ack>
<p>We thank Dr. Cristina Acidini, <italic>Soprintendenza Speciale per il Patrimonio Storico Artistico e Etnoantropologico per il Polo Museale</italic>, Florence, Italy for allowing the use of image of the painting displayed at the <italic>Galleria degli Uffizi</italic>, Florence, Italy. We thank L. Daitch for her contribution to the editing of the manuscript.</p>
</ack>
<ref-list>
<title>References</title>
<ref id="B1"><label>1</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Hockney</surname> <given-names>D</given-names></name></person-group>. <source>Secret Knowledge: Discovering the Lost Techniques of the Old Masters</source>. <publisher-loc>New York</publisher-loc>: <publisher-name>Viking Studio</publisher-name> (<year>2001</year>).</citation></ref>
<ref id="B2"><label>2</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Robb</surname> <given-names>PM</given-names></name></person-group>. <source>The Man Who Became Caravaggio</source>. <publisher-loc>Sydney</publisher-loc>: <publisher-name>Duffy &#x00026; Snellgrove</publisher-name> (<year>1998</year>).</citation></ref>
<ref id="B3"><label>3</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Aronson</surname> <given-names>JK</given-names></name> <name><surname>Ramachandran</surname> <given-names>M</given-names></name></person-group>. <article-title>The diagnosis of art: Caravaggio&#x00027;s jaundiced Bacchus</article-title>. <source>J R Soc Med</source> (<year>2007</year>) <volume>100</volume>(<issue>9</issue>):<fpage>429</fpage>&#x02013;<lpage>30</lpage>.<pub-id pub-id-type="doi">10.1258/jrsm.100.9.429</pub-id></citation></ref>
<ref id="B4"><label>4</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kupfer</surname> <given-names>DJ</given-names></name> <name><surname>Kuhl</surname> <given-names>EA</given-names></name> <name><surname>Wulsin</surname> <given-names>L</given-names></name></person-group>. <article-title>Psychiatry&#x00027;s integration with medicine: the role of DSM-5</article-title>. <source>Annu Rev Med</source> (<year>2013</year>) <volume>64</volume>:<fpage>385</fpage>&#x02013;<lpage>92</lpage>.<pub-id pub-id-type="doi">10.1146/annurev-med-050911-161945</pub-id><pub-id pub-id-type="pmid">23327527</pub-id></citation></ref>
<ref id="B5"><label>5</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kupfer</surname> <given-names>DJ</given-names></name> <name><surname>Kuhl</surname> <given-names>EA</given-names></name> <name><surname>Regier</surname> <given-names>DA</given-names></name></person-group>. <article-title>DSM-5 &#x02013; the future arrived</article-title>. <source>JAMA</source> (<year>2013</year>) <volume>309</volume>(<issue>16</issue>):<fpage>1691</fpage>&#x02013;<lpage>2</lpage>.<pub-id pub-id-type="doi">10.1001/jama.2013.5009</pub-id><pub-id pub-id-type="pmid">23440257</pub-id></citation></ref>
<ref id="B6"><label>6</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Edwards</surname> <given-names>AC</given-names></name> <name><surname>Gillespie</surname> <given-names>NA</given-names></name> <name><surname>Aggen</surname> <given-names>SH</given-names></name> <name><surname>Kendler</surname> <given-names>KS</given-names></name></person-group>. <article-title>Assessment of a modified DSM-5 diagnosis of alcohol use disorder in a genetically informative population</article-title>. <source>Alcohol Clin Exp Res</source> (<year>2013</year>) <volume>37</volume>(<issue>3</issue>):<fpage>443</fpage>&#x02013;<lpage>51</lpage>.<pub-id pub-id-type="doi">10.1111/j.1530-0277.2012.01954.x</pub-id><pub-id pub-id-type="pmid">23347196</pub-id></citation></ref>
<ref id="B7"><label>7</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Huerta</surname> <given-names>M</given-names></name> <name><surname>Bishop</surname> <given-names>SL</given-names></name> <name><surname>Duncan</surname> <given-names>A</given-names></name> <name><surname>Hus</surname> <given-names>V</given-names></name> <name><surname>Lord</surname> <given-names>C</given-names></name></person-group>. <article-title>Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders</article-title>. <source>Am J Psychiatry</source> (<year>2012</year>) <volume>169</volume>(<issue>10</issue>):<fpage>1056</fpage>&#x02013;<lpage>64</lpage>.<pub-id pub-id-type="doi">10.1176/appi.ajp.2012.12020276</pub-id><pub-id pub-id-type="pmid">23032385</pub-id></citation></ref>
<ref id="B8"><label>8</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Compton</surname> <given-names>WM</given-names></name> <name><surname>Dawson</surname> <given-names>DA</given-names></name> <name><surname>Goldstein</surname> <given-names>RB</given-names></name> <name><surname>Grant</surname> <given-names>BF</given-names></name></person-group>. <article-title>Crosswalk between DSM-IV dependence and DSM-5 substance use disorders for opioids, cannabis, cocaine and alcohol</article-title>. <source>Drug Alcohol Depend</source> (<year>2013</year>). <pub-id pub-id-type="doi">10.1016/j.drugalcdep.2013.02.036</pub-id></citation></ref>
</ref-list>
</back>
</article>