AUTHOR=Xu Runhao , Guo Jiajun , Li Weihao , Xie Zimo , Zhai Yujia , Jiang Siyuan , Li Yue , Xia Kailun , Chen Yucheng 
  
TITLE=Accuracy of wearable smartwatch for measuring blood pressure and oxygen saturation across a wide altitudinal gradient: a comparative study in Migrant and Resident populations
  
JOURNAL=Frontiers in Physiology
  
VOLUME=Volume 17 - 2026
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1746894
  
DOI=10.3389/fphys.2026.1746894
  
ISSN=1664-042X
  
ABSTRACT=BackgroundWearable devices are increasingly used to monitor physiological parameters, yet their accuracy at high altitude remains uncertain. We evaluated a commercial smartwatch for peripheral oxygen saturation (SpO2) and blood pressure (BP) measurement across a wide altitudinal gradient and examined whether adaptation status and ethnicity influence accuracy.MethodsA prospective observational study was conducted at four sites in Western China (500–4,014 m). The Migrant cohort (n = 24) comprised lowlanders assessed longitudinally at all sites; the Resident cohort (n = 85) comprised long-term high-altitude residents sampled cross-sectionally. Smartwatch measurements (HUAWEI Watch GT3 Pro) were compared with reference devices using Bland–Altman analysis and benchmarked against ANSI/AAMI/ISO standards.ResultsSpO2 accuracy was maintained across altitudes, with RMSE of 0.19%–0.81%, within the ISO 80601-2-61:2017 threshold (≤3%). BP showed wider limits of agreement with a persistent negative bias. SBP in Migrants at 2,560 m exceeded ISO 81060-2:2018 criteria for both bias (−5.29 mmHg) and SD (9.88 mmHg; threshold ≤8 mmHg). DBP bias in Migrants at 4,014 m also exceeded the ±5 mmHg threshold (−5.28 mmHg). No significant differences in measurement error were found between Migrants and Residents or between Han and Zang ethnicities after FDR correction, though error variability was markedly higher in acutely exposed individuals (variance ratio up to 17.5 for SpO2).ConclusionSmartwatch SpO2 readings remained within ISO benchmark thresholds, supporting trend monitoring utility. BP readings showed specific deviations from ISO criteria during acute exposure and warrant cautious interpretation above 2,500 m.