AUTHOR=Yalcin Murat , Latoschik Marc Erich 
  
TITLE=End-to-end non-invasive ECG signal generation from PPG signal: a self-supervised learning approach
  
JOURNAL=Frontiers in Physiology
  
VOLUME=Volume 17 - 2026
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2026.1694995
  
DOI=10.3389/fphys.2026.1694995
  
ISSN=1664-042X
  
ABSTRACT=Electrocardiogram (ECG) signals are frequently utilized for detecting important cardiac events, such as variations in ECG intervals, as well as for monitoring essential physiological metrics, including heart rate (HR) and heart rate variability (HRV). However, the accurate measurement of ECG traditionally requires a clinical environment, thereby limiting its feasibility for continuous, everyday monitoring. In contrast, Photoplethysmography (PPG) offers a non-invasive, cost-effective optical method for capturing cardiac data in daily settings and is increasingly utilized in various clinical and commercial wearable devices. However, PPG measurements are significantly less detailed than those of ECG. In this study, we propose a novel approach to synthesize ECG signals from PPG signals, facilitating the generation of robust ECG waveforms using a simple, unobtrusive wearable setup. Our approach utilizes a Transformer-based Generative Adversarial Network model, designed to accurately capture ECG signal patterns and enhance generalization capabilities. Additionally, we incorporate self-supervised learning techniques to enable the model to learn diverse ECG patterns through specific tasks. Model performance is evaluated using various metrics, including heart rate calculation and root mean squared error (RMSE) on two different datasets. The comprehensive performance analysis demonstrates that our model exhibits superior efficacy in generating accurate ECG signals (with reducing 83.9% and 72.4% of the heart rate calculation error on MIMIC III and Who is Alyx? datasets, respectively), suggesting its potential application in the healthcare domain to enhance heart rate prediction and overall cardiac monitoring. As an empirical proof of concept, we also present an Atrial Fibrillation (AF) detection task, showcasing the practical utility of the generated ECG signals for cardiac diagnostic applications. To encourage replicability and reuse in future ECG generation studies, we have made both the dataset and the code publicly available.