AUTHOR=Muniz-Pardos Borja , Angeloudis Konstantinos , Zelenkova Irina , Guppy Fergus M. , Marco-Contreras Luis A. , Gomez-Bruton Alejandro , Lozano-Berges Gabriel , Pitsiladis Yannis , Casajus Jose A. TITLE=Advanced footwear technology in well-trained athletes: methodological insights from outdoor running JOURNAL=Frontiers in Physiology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1713902 DOI=10.3389/fphys.2025.1713902 ISSN=1664-042X ABSTRACT=BackgroundAdvanced footwear technology (AFT) is reported to elicit an approximate 4% average improvement in running economy (RE). However, a large inter-individual variability remains unexplained, and limited research examined the impact of AFT during outdoor running. The aim was to compare the physiological, biomechanical and perceptual responses of 36 well-trained athletes to running outdoors using three different AFT and a traditional racing shoe.MethodsThirty-six well-trained athletes (19 males and 17 females) had their maximal aerobic capacity (V˙O2max) and anaerobic threshold (AT) determined in laboratory conditions and were familiarised to the different shoe running conditions. Within 7 days, athletes ran 4 × 6 min running bouts, paced outdoors at 95% of their individual AT with 10 min recovery, in three different AFT conditions and a traditional flat. Oxygen uptake (V˙O2), heart rate, rating of perceived exertion (RPE), lactate, shoe perception, and biomechanical responses were compared between the four running trials.ResultsNo differences were observed in the RE between shoe conditions, with a great inter-individual variability (range: 12% impairment to 14% improvement in RE). This variability was accompanied by a significant V˙O2 order effect across exercise bouts (bout 2 lower than one [-1.1 mL/kg/min, p = 0.002]; bout 3 lower than 2 [-0.8 mL/kg/min, p = 0.027]; no differences between bouts 3 and 4). This variability was likely due to methodological issues such as one squared-wave RE measurement per shoe condition or the lack of a mirrored experimental design, among others. There was no order effect in other physiological or biomechanical variables. No significant differences were found in lactate, heart rate or rate of perceived exertion between running trials. Biomechanical responses to the different shoe conditions were also highly variable. One of the advanced AFT shoes showed a greater strike angle (+2.07°; p = 0.001), with no other significant differences between shoes conditions.ConclusionThe large variability in the physiological response to AFT may be explained by methodological considerations. A minimum of two-bout RE measurements, the use of a mirrored order, a sufficient familiarisation with shoes and experimental designs, among other considerations, seem crucial to enhance the ecological validity and reduce data variability.