AUTHOR=Chaigne Sebastien TITLE=Breaking the one-dimensional paradigm: why cardiovascular research needs a multi-systems revolution JOURNAL=Frontiers in Physiology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1699532 DOI=10.3389/fphys.2025.1699532 ISSN=1664-042X