AUTHOR=Cerqueira Mikhail Santos , Pereira Rafael , Maciel Daniel Germano , Pinto Cláudia Thais Pereira , Rolnick Nicholas , Vieira Wouber Hérickson de Brito 
  
TITLE=Occlusion pressure and blood pressure adaptations following low-load blood flow restriction training versus moderate-load training: a pilot randomized clinical trial in patients with knee osteoarthritis
  
JOURNAL=Frontiers in Physiology
  
VOLUME=Volume 16 - 2025
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1693341
  
DOI=10.3389/fphys.2025.1693341
  
ISSN=1664-042X
  
ABSTRACT=ObjectiveThis pilot study investigated potential adaptations in limb occlusion pressure (LOP) and compared LOP between low-load resistance training with blood flow restriction (LL-BFR) and traditional moderate-load training (ML) over 9 weeks in patients with knee osteoarthritis (KOA). Secondarily, we compared systolic blood pressure (SBP) and diastolic blood pressure (DBP) adaptations between these groups.MethodsSeventeen KOA patients were randomly assigned to the LL-BFR or ML groups. The LL-BFR group performed 75 repetitions (10% 1RM; 60% of LOP). The ML group performed 24 repetitions (60% 1RM; 10% [SHAM] of LOP). In both groups, exercises involving LOP were bilateral hack machine squat and knee extension exercises. LOP, SBP, and DBP were measured before and every 3 weeks until the ninth training week.ResultsAfter 9 weeks, there were no statistically significant changes in LOP, SBP, or DBP within or between groups. LOP decreased by −32.9 mmHg (95% CI: −68.9 to 3.2) in LL-BFR and −17.2 mmHg (95% CI: −49.0 to 14.6) in ML, achieving clinical significance [relative error variance (REV) = 14.6 mmHg]. SBP decreased by −7.5 mmHg (95% CI: −15.6 to 0.6) in LL-BFR and −1.1 mmHg (95% CI: −8.2 to 6.0) in ML. DBP decreased by −3.7 mmHg (95% CI: −9.2 to 1.7) in LL-BFR and −1.9 mmHg (95% CI: −6.8 to 2.9) in ML.ConclusionWe observed a non-significant trend toward a reduction in LOP following 9 weeks of LL-BFR in patients with KOA, with a mean point estimate that exceeded a pre-defined threshold for clinical significance, although the wide confidence intervals indicate substantial uncertainty. Furthermore, SBP and DBP showed no significant changes, and no group differences emerged across outcomes. Practically, these findings suggest that LOP remains stable throughout a rehabilitation program, potentially reducing the burden of frequent LOP reassessment in clinical LL-BFR applications.Trial registrationhttps://ensaiosclinicos.gov.br/rg/RBR-6pcrfm/.