AUTHOR=Pan Tingming , Dong Zhong , Zhang Hongjie , Yang Fengmin , Chen Yating 

TITLE=Single-cell sequencing reveals cellular heterogeneity and molecular mechanisms in tendon and enthesis injury repair

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1685955

DOI=10.3389/fphys.2025.1685955

ISSN=1664-042X

ABSTRACT=BackgroundTendon and enthesis injuries represent a significant global health challenge, severely impairing patient mobility and self-care abilities while imposing substantial medical burdens.Main BodyPoor clinical outcomes in tendon healing stem from the complex enthesis, which involves diverse cell types and signaling pathways. Recent advances in single-cell sequencing technologies have revealed detailed cellular diversity and function in tendon and tendon-bone healing. Using multimodal integration, researchers have identified precise subpopulations of tendon and enthesis cells. They have also clarified cell-to-cell crosstalk and mapped differentiation paths during healing.ConclusionThese new findings, guided by emerging methodological advancements. They offer innovative perspectives for developing targeted clinical interventions for tendon and enthesis injury.