AUTHOR=Liu Ziyan , Liu Ziyi , Wang Yuan , Wan Xiyao , Huang Xiaohua 

TITLE=Machine learning-based predictive analysis of energy efficiency factors necessary for the HIFU treatment of adenomyosis

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1602866

DOI=10.3389/fphys.2025.1602866

ISSN=1664-042X

ABSTRACT=PurposeThis study aimed to develop a joint model combining T2-weighted imaging (T2WI) suppressed fat radiomics, and clinical parameters to predict the energy efficiency factor (EEF) required for high-intensity focused ultrasound (HIFU) ablation in patients with adenomyosis.Materials and methodsThis retrospective study included 169 adenomyosis patients who underwent HIFU ablation between September 2021 and May 2024. EEF values were calculated based on T2WI fat suppression (T2WI-FS) sequences, and radiomics features were extracted. Predictive features were selected using minimum redundancy maximum relevance (MRMR) and least absolute shrinkage and selection operator (LASSO) methods, and two joint—based on decision tree and random forest algorithms—models were developed for EEF prediction.ResultsThe decision tree model achieved a mean absolute error (MAE) of 8.095 on the test set, while the random forest model exhibited an MAE of 8.231. The Wilcoxon rank-sum test for the test set revealed that the discrepancy in predictive performance between the two models was statistically significant (p < 0.05). The correlation coefficients were 0.768 and 0.777, and the R2 coefficients of the two models in the test set were 0.559 and 0.549, respectively.ConclusionThe joint model integrating T2WI radiomics and clinical data effectively predicted EEF values for HIFU ablation in adenomyosis. This approach provides a foundation for optimizing HIFU dosing strategies and enhancing treatment safety and efficacy.