Front. Physiol. Frontiers in Physiology Front. Physiol. 1664-042X Frontiers Media S.A. 1256251 10.3389/fphys.2023.1256251 Physiology Correction Corrigendum: Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation Squarcio et al. 10.3389/fphys.2023.1256251 Squarcio Fabio 1 † Hitrec Timna 1 † Piscitiello Emiliana 1 2 Cerri Matteo 1 Giovannini Catia 2 3 Martelli Davide 1 Occhinegro Alessandra 1 2 Taddei Ludovico 1 Tupone Domenico 1 4 Amici Roberto 1 Luppi Marco 1 2 * 1 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy 2 Centre for Applied Biomedical Research—CRBA, St. Orsola Hospital, University of Bologna, Bologna, Italy 3 Department of Experimental, Diagnostic and Specialty Medicines, University of Bologna, Bologna, Italy 4 Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, United States

Edited and reviewed by: Jérémy Terrien, Muséum National d’Histoire Naturelle, France

 *Correspondence: Marco Luppi, marco.luppi@unibo.it

These authors have contributed equally to this work and share first authorship

 25 07 2023 2023 14 1256251 10 07 2023 13 07 2023 Copyright © 2023 Squarcio, Hitrec, Piscitiello, Cerri, Giovannini, Martelli, Occhinegro, Taddei, Tupone, Amici and Luppi. 2023 Squarcio, Hitrec, Piscitiello, Cerri, Giovannini, Martelli, Occhinegro, Taddei, Tupone, Amici and Luppi

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 A Corrigendum on Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation by Squarcio F, Hitrec T, Piscitiello E, Cerri M, Giovannini C, Martelli D, Occhinegro A, Taddei L, Tupone D, Amici R and Luppi M (2023). Front. Physiol. 14:1129278. doi: 10.3389/fphys.2023.1129278 deep hypothermia microtubules melatonin glycogen synthase kinase 3β hippocampus parietal cortex section-at-acceptance Metabolic Physiology

In the published article, there was an error in Figure 4E as published. The only histogram bars represented in Panel E left side (referred to P-Cx [i.e., Parietal cortex]) are wrong, together with the relative “y” scale. However, the representative Western blot bands depicted at the bottom of the histograms are correct, as described in the original caption that is also reported below. The corrected Figure 4 and its correct original caption appear below.

Western blot detection of the main enzymes involved in phosphorylation and dephosphorylation of Tau, determined in brain extracts of the parietal cortex (P-Cx) and hippocampus (Hip). Below each histogram, WB representative samples are shown for each experimental condition. (A) glycogen-synthase kinase-3β (GSK3β), the main kinase targeting Tau; (B) p[S9]-GSK3β (inactive form of GSK3β, phosphorylated at Ser9); (C) protein phosphatase-2A (PP2A), the main phosphatase targeting Tau; (D) different isoforms of Akt (protein kinase-B; Akt 1/2/3), kinases targeting GSK3β at Ser9 and antiapoptotic factors; (E) p[S473] Akt, the active form of Akt 1/2/3, phosphorylated at Ser473. Data are normalized by β-actin and expressed as means ± S.E.M., n = 3. *: p < 0.05 vs. C. Experimental groups (see Figure 1): C, control; N, samples taken at nadir of hypothermia, during ST; ER, early recovery, samples taken when Tb reached 35.5°C following ST; R3, samples taken 3 h after ER; R6, samples taken 6 h after ER.

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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