<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<?covid-19-tdm?>
<article xml:lang="EN" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="editorial">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Physiol.</journal-id>
<journal-title>Frontiers in Physiology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Physiol.</abbrev-journal-title>
<issn pub-type="epub">1664-042X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fphys.2021.761644</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Physiology</subject>
<subj-group>
<subject>Editorial</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Editorial: The Tribute of Physiology for the Understanding of COVID-19 Disease</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Lefth&#x000E9;riotis</surname> <given-names>Georges</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/983210/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Wray</surname> <given-names>Susan</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/1024440/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Girardi</surname> <given-names>Adriana Castello Costa</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/314252/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Vidal-Petiot</surname> <given-names>Emmanuelle</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/970229/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Bailey</surname> <given-names>Matthew A.</given-names></name>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/76966/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Schechtman</surname> <given-names>Deborah</given-names></name>
<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/23241/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Ravi</surname> <given-names>Nistala</given-names></name>
<xref ref-type="aff" rid="aff7"><sup>7</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/118013/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Noble</surname> <given-names>Denis</given-names></name>
<xref ref-type="aff" rid="aff8"><sup>8</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/129310/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Universit&#x000E9; C&#x000F4;te d&#x00027;Azur, CNRS, LP2M</institution>, <addr-line>Nice</addr-line>, <country>France</country></aff>
<aff id="aff2"><sup>2</sup><institution>University of Liverpool</institution>, <addr-line>Liverpool</addr-line>, <country>United Kingdom</country></aff>
<aff id="aff3"><sup>3</sup><institution>Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of S&#x000E3;o Paulo Medical School</institution>, <addr-line>S&#x000E3;o Paulo</addr-line>, <country>Brazil</country></aff>
<aff id="aff4"><sup>4</sup><institution>Assistance Publique Hopitaux De Paris</institution>, <addr-line>Paris</addr-line>, <country>France</country></aff>
<aff id="aff5"><sup>5</sup><institution>Centre for Cardiovascular Science, University of Edinburgh</institution>, <addr-line>Edinburgh</addr-line>, <country>United Kingdom</country></aff>
<aff id="aff6"><sup>6</sup><institution>University of S&#x000E3;o Paulo</institution>, <addr-line>S&#x000E3;o Paulo</addr-line>, <country>Brazil</country></aff>
<aff id="aff7"><sup>7</sup><institution>University of Missouri</institution>, <addr-line>Columbia, KY</addr-line>, <country>United States</country></aff>
<aff id="aff8"><sup>8</sup><institution>University of Oxford</institution>, <addr-line>Oxford</addr-line>, <country>United Kingdom</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited and reviewed by: Geoffrey A. Head, Baker Heart and Diabetes Institute, Australia</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Georges Lefth&#x000E9;riotis <email>leftheriotis&#x00040;unice.fr</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology</p></fn></author-notes>
<pub-date pub-type="epub">
<day>27</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="collection">
<year>2021</year>
</pub-date>
<volume>12</volume>
<elocation-id>761644</elocation-id>
<history>
<date date-type="received">
<day>20</day>
<month>08</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>30</day>
<month>08</month>
<year>2021</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2021 Lefth&#x000E9;riotis, Wray, Girardi, Vidal-Petiot, Bailey, Schechtman, Ravi and Noble.</copyright-statement>
<copyright-year>2021</copyright-year>
<copyright-holder>Lefth&#x000E9;riotis, Wray, Girardi, Vidal-Petiot, Bailey, Schechtman, Ravi and Noble</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<related-article id="RA1" related-article-type="commentary-article" xlink:href="https://www.frontiersin.org/research-topics/14265/the-tribute-of-physiology-for-the-understanding-of-covid-19-disease" ext-link-type="uri">Editorial on the Research Topic <article-title>The Tribute of Physiology for the Understanding of COVID-19 Disease</article-title></related-article>
<kwd-group>
<kwd>editorial</kwd>
<kwd>physiology</kwd>
<kwd>COVID-19</kwd>
<kwd>pandemia</kwd>
<kwd>collection</kwd>
</kwd-group>
<counts>
<fig-count count="0"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="0"/>
<page-count count="2"/>
<word-count count="826"/>
</counts>
</article-meta>
</front>
<body>
<p>While the specter of the COVID-19 pandemic appears to be gradually receding, the lessons learned from the pandemic are still relevant today. During the year 2021, a collective of physiologists belonging to different national (French, UK, Brazil,...) and European societies (federation  of the European Society of Physiology&#x02014;FEPS), joined forces to make their contribution to the scientific knowledge accumulated during this pandemic.</p>
<p>More than 50 articles have been submitted for publication, and viewed more than 450,000 times, demonstrating the interest of the physiological community in the subject. The articles published in this collection have provided new information or reflections in all areas of physiology, from immunity to respiratory, cardiovascular function, including hemostasis, neurophysiology or even certain related aspects to epidemiology.</p>
<p>The objective of the collection was to provide a better understanding of the interaction between COVID-19 and physiological functions at different stages of organization, from genes to the whole living organism in different disciplinary fields, including cardiovascular, renal, gastrointestinal, endocrine, respiratory and pulmonary, immune and neuronal systems and their physiological functions.</p>
<p>It is important to note that the roles of environmental factors, including age, gender, smoking, metabolic imbalances (e.g., diabetes), as well as immuno-allergic status were taken into account in the selection of articles. The symptoms of the COVID-19 infection have uniquely revealed a richness and diversity focused on a limited time and affecting different populations of cultures and ethnicities. Symptomatology has illustrated interactions and relationships between different physiological functions (e.g., anosmia and neurological symptoms).</p>
<p>The entire invited editorial team is also engaged in the evaluation of interdisciplinary opinions and points of view, as well as data from original work of the different physiological systems targeted by SARS-Cov-2.</p>
<p>The virus is still there with its share of unknowns and uncertainties, and the scientific community too, in an attempt to answer questions from the medical community and human populations in general. The anti-COVID vaccination and its procession of sometimes unusual manifestations is in itself another chapter that opens in the history of this pandemic. There is still significant scientific work to be done in these areas in order to improve our understanding of the mechanisms of this pandemic and to better care for patients and protect us from the next waves.</p>
<sec id="s1">
<title>Author Contributions</title>
<p>All authors contributed equally to the editorial board of the collection.</p>
</sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s2">
<title>Publisher&#x00027;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</body>
<back>
<ack><p>The invited editorial committee would like to thank all the contributors to this collection, authors and reviewers for their availability and their investment in the editorial process.</p>
</ack>
</back>
</article>