<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<article article-type="research-article" dtd-version="2.3" xml:lang="EN" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Phys.</journal-id>
<journal-title>Frontiers in Physics</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Phys.</abbrev-journal-title>
<issn pub-type="epub">2296-424X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">766615</article-id>
<article-id pub-id-type="doi">10.3389/fphy.2021.766615</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Physics</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Identifying Multiple Influential Spreaders in Complex Networks by Considering the Dispersion of Nodes</article-title>
<alt-title alt-title-type="left-running-head">Tao&#x2009; et&#x20;al.</alt-title>
<alt-title alt-title-type="right-running-head">Identifying Multiple Influential Spreaders</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Tao&#x2009;</surname>
<given-names>Li</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1022758/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Liu&#x2009;</surname>
<given-names>Mutong</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhang&#x2009;</surname>
<given-names>Zili</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1279658/overview"/>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Luo&#x2009;</surname>
<given-names>Liang</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001">&#x2a;</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<sup>1</sup>
<institution>School of Computer and Information Science, Southwest University</institution>, <addr-line>Chongqing</addr-line>, <country>China</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Computer Science, Hong Kong Baptist University</institution>, <addr-line>Kowloon</addr-line>, <country>Hong Kong, SAR, China</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>
<bold>Edited by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1271072/overview">Shudong Li</ext-link>, Guangzhou University, China</p>
</fn>
<fn fn-type="edited-by">
<p>
<bold>Reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1463238/overview">Jiajin Huang</ext-link>, Beijing University of Technology, China</p>
<p>
<ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1486554/overview">Kevin Du</ext-link>, The University of Hong Kong, Hong Kong, SAR China</p>
</fn>
<corresp id="c001">&#x2a;Correspondence: Liang Luo&#x2009;, <email>luoliang@swu.edu.cn</email>
</corresp>
<fn fn-type="other">
<p>This article was submitted to Social Physics, a section of the journal Frontiers in Physics</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>03</day>
<month>01</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="collection">
<year>2021</year>
</pub-date>
<volume>9</volume>
<elocation-id>766615</elocation-id>
<history>
<date date-type="received">
<day>29</day>
<month>08</month>
<year>2021</year>
</date>
<date date-type="accepted">
<day>12</day>
<month>11</month>
<year>2021</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2022 Tao&#x2009;, Liu&#x2009;, Zhang&#x2009; and Luo&#x2009;.</copyright-statement>
<copyright-year>2022</copyright-year>
<copyright-holder>Tao&#x2009;, Liu&#x2009;, Zhang&#x2009; and Luo&#x2009;</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these&#x20;terms.</p>
</license>
</permissions>
<abstract>
<p>Identifying multiple influential spreaders, which relates to finding <italic>k</italic> (<italic>k</italic>&#x20;&#x3e; 1) nodes with the most significant influence, is of great importance both in theoretical and practical applications. It is usually formulated as a node-ranking problem and addressed by sorting spreaders&#x2019; influence as measured based on the topological structure of interactions or propagation process of spreaders. However, ranking-based algorithms may not guarantee that the selected spreaders have the maximum influence, as these nodes may be adjacent, and thus play redundant roles in the propagation process. We propose three new algorithms to select multiple spreaders by taking into account the dispersion of nodes in the following ways: (1) improving a well-performed local index rank (LIR) algorithm by extending its key concept of the local index (an index measures how many of a node&#x2019;s neighbors have a higher degree) from first-to second-order neighbors; (2) combining the LIR and independent set (IS) methods, which is a generalization of the coloring problem for complex networks and can ensure the selected nodes are non-adjacent if they have the same color; (3) combining the improved second-order LIR method and IS method so as to make the selected spreaders more disperse. We evaluate the proposed methods against six baseline methods on 10 synthetic networks and five real networks based on the classic susceptible-infected-recovered (SIR) model. The experimental results show that our proposed methods can identify nodes that are more influential. This suggests that taking into account the distances between nodes may aid in the identification of multiple influential spreaders.</p>
</abstract>
<kwd-group>
<kwd>identification of multiple influential spreaders</kwd>
<kwd>dispersion of nodes</kwd>
<kwd>location index rank algorithm</kwd>
<kwd>independent set&#x20;algorithm</kwd>
<kwd>susceptible-infected-recovered model</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec id="s1">
<title>1 Introduction</title>
<p>Many real-world problems involve the identification of multiple influential nodes in complex networks, such as finding a few individuals who are critical to the spread of information on the internet, or who may speed up the transmission process of pestilence in crowds once infected [<xref ref-type="bibr" rid="B1">1</xref>]. The problem of identifying multiple influential nodes differs from that of discovering the most influential nodes. The latter refers to finding the <italic>k</italic> (<italic>k</italic>&#x20;&#x3e; 1) most influential spreaders, which is commonly addressed by ranking the influence of individual nodes. The former involves the identification of a set of <italic>k</italic> nodes with the maximum influence as a whole. That is, identifying multiple influential nodes should take into account the different roles that nodes play in the propagation process rather than just evaluating their individual influence&#x20;[<xref ref-type="bibr" rid="B2">2</xref>].</p>
<p>Methods to identify multiple influential spreaders fall in three categories. The first regards this as an influence maximization (IM) problem. Some well-known methods include the greedy [<xref ref-type="bibr" rid="B3">3</xref>], new greedy [<xref ref-type="bibr" rid="B4">4</xref>], community-based greedy [<xref ref-type="bibr" rid="B5">5</xref>], k-medoid [<xref ref-type="bibr" rid="B6">6</xref>], two-phase influence maximization [<xref ref-type="bibr" rid="B7">7</xref>], and collective influence [<xref ref-type="bibr" rid="B8">8</xref>] algorithms. However, as the IM problem is NP-hard, these algorithms are challenged by increasing network sizes, and thus are not applicable to huge real networks.</p>
<p>Methods in the second category attempt to identify multiple influential nodes by ranking their influences, which are calculated according to various topology-based centrality measures: 1) classic topological centrality metrics, such as degree centrality [<xref ref-type="bibr" rid="B9">9</xref>], betweenness centrality [<xref ref-type="bibr" rid="B10">10</xref>], and closeness centrality [<xref ref-type="bibr" rid="B10">10</xref>]; 2) centrality measures that take into account multiple (global or local) network features, such as KED centrality [<xref ref-type="bibr" rid="B11">11</xref>], efficiency centrality (EC) [<xref ref-type="bibr" rid="B12">12</xref>], composite centrality based on analytic hierarchy process [<xref ref-type="bibr" rid="B13">13</xref>], and classified neighbors centrality [<xref ref-type="bibr" rid="B14">14</xref>]; and 3) local-information-based iterative algorithms such as PageRank [<xref ref-type="bibr" rid="B15">15</xref>], LeaderRank [<xref ref-type="bibr" rid="B16">16</xref>], and VoteRank [<xref ref-type="bibr" rid="B17">17</xref>]. However, the ranking approach may not always find a set of nodes with the maximum influence [<xref ref-type="bibr" rid="B18">18</xref>], possibly because they separately measure the influence of each node, and thus omit overlapping effects of topologically adjacent top-ranked&#x20;nodes.</p>
<p>Algorithms in the third category consider the distance between nodes when evaluating node importance. For instance, the local index rank (LIR) algorithm [<xref ref-type="bibr" rid="B19">19</xref>] is based on the local index (<italic>LI</italic>) value of a node, which represents the number of neighbors whose degree exceeds that of the focus node. Spreaders are selected from nodes whose <italic>LI</italic> values are 0 (i.e.,&#x20;0-<italic>LI</italic> nodes). However, the LIR method cannot avoid some adjacent 0-LI nodes, and sometimes there are not enough 0-<italic>LI</italic> nodes to be selected as spreaders. Another example is the independent set (IS) algorithm [<xref ref-type="bibr" rid="B20">20</xref>], which divides nodes into independent sets by the Welsh-Powell coloring algorithm and selects spreaders in the largest independent set to ensure that selected nodes are non-adjacent. However, special situations may occur, such as not enough spreaders in the largest independent set; meanwhile directly selecting rest spreaders in following independent sets may derogate the advantages brought by independent&#x20;set.</p>
<p>We propose three methods with different degrees of dispersion to identify multiple spreaders. The first one is LIR-2 method which extends the concept of the local index to second-order neighbors and does not restrict the spreaders&#x2019; selection from the 0-LI nodes. By doing so, this method enlarges the distance between the 0-LI nodes and can guarantee to select enough spreaders. The second one is IS-LIR method which hybrids LIR and IS to ensure that nodes in the same independent set are non-adjacent. The third one is IS-LIR-2 method, which hybrids the improved second-order LIR method and IS method so that the selected spreaders are more dispersed. Comparing the proposed three methods with traditional methods for multiple spreader identification on 10 synthetic networks and five real networks based on the SIR propagation model, we find our methods more effective in maximizing the size of the spreading coverage, and that a higher dispersion of the selected multiple spreaders helps to amplify the spreading.</p>
<p>The rest of this paper is organized as follows.<xref ref-type="sec" rid="s2">Sec. 2</xref> introduces work relating to the identification of multiple influential spreaders. <xref ref-type="sec" rid="s3">Sec. 3</xref> formalizes the research problem and proposes our method. <xref ref-type="sec" rid="s4">Sec. 4</xref> describes our experiments, including baseline methods, the SIR propagation model, evaluation metrics, parameter settings for experiments, and datasets. <xref ref-type="sec" rid="s5">Sec. 5</xref> provides the experimental results and discusses why diversity should be considered when we select a set of influential spreaders. We summarize our work in <xref ref-type="sec" rid="s6">Sec.&#x20;6</xref>.</p>
</sec>
<sec id="s2">
<title>2 Related Work</title>
<p>Identifying a set of influential nodes in a network is important for designing network immunization [<xref ref-type="bibr" rid="B21">21</xref>], system control strategy [<xref ref-type="bibr" rid="B22">22</xref>] and improving the network robustness [<xref ref-type="bibr" rid="B23">23</xref>,<xref ref-type="bibr" rid="B24">24</xref>]. Work about multiple spreader identification falls in three categories. The first regards it as an influence maximization problem [<xref ref-type="bibr" rid="B3">3</xref>], and thus utilizes optimization algorithms to directly identify a set of spreaders. The greedy algorithm [<xref ref-type="bibr" rid="B3">3</xref>] is a classic example. These algorithms are accurate but time-consuming, and thus do not suit large-scale networks. Some researchers employ information about network structures to reduce the time complexity while maintaining the high accuracy of classic optimization algorithms. The NewGreedy algorithm [<xref ref-type="bibr" rid="B4">4</xref>] removes edges that do not contribute to propagation, so as to speed up the simulation process. The community-based greedy algorithm (CGA) [<xref ref-type="bibr" rid="B5">5</xref>] mines the top-<italic>k</italic> spreaders from detected communities so as to reduce the running time. Another algorithm [<xref ref-type="bibr" rid="B6">6</xref>] constructs an information transfer probability matrix and uses the k-medoid clustering algorithm to find the most centrally located nodes in clusters as spreaders. Two-phase influence maximization (TIM) [<xref ref-type="bibr" rid="B7">7</xref>] includes the phases of parameter estimation and node selection to reduce time complexity.</p>
<p>Methods in the second category select the top-ranked spreaders, whose influence is calculated based on network topological information. Classic indicators such as degree centrality [<xref ref-type="bibr" rid="B9">9</xref>], betweenness centrality [<xref ref-type="bibr" rid="B10">10</xref>], closeness centrality [<xref ref-type="bibr" rid="B10">10</xref>], and coreness centrality [<xref ref-type="bibr" rid="B25">25</xref>], have been utilized to estimate the influence of spreaders. Some researchers take into account multiple (global or local) network features when measuring the importance of spreaders [<xref ref-type="bibr" rid="B26">26</xref>]. For instance, KED centrality [<xref ref-type="bibr" rid="B11">11</xref>] combines the number and diversity of paths. Composite centrality based on the analytic hierarchy process (AHP) [<xref ref-type="bibr" rid="B13">13</xref>] combines degree, betweenness, and closeness centrality. Classified neighbors centrality (CNC) [<xref ref-type="bibr" rid="B14">14</xref>] classifies the neighbors of a focal node into four groups according to the removal order in the process of k-shell decomposition, weights each class differentially, and sums them to characterize the spreading capacity of the node. PageRank [<xref ref-type="bibr" rid="B15">15</xref>], LeaderRank [<xref ref-type="bibr" rid="B16">16</xref>], and VoteRank [<xref ref-type="bibr" rid="B17">17</xref>] all consider the importance of a node itself and its connections with other nodes to identify influential nodes. These rank-based algorithms often have simple forms and low time complexity and can effectively mine a single important node. However, they may not efficiently find multiple important spreaders because they seldom consider interactions between spreaders, i.e.,&#x20;they ignore the overlapping effects of top-ranked nodes if they are topologically adjacent.</p>
<p>Algorithms in the third category attempt to minimize the overlapping effects of spreaders during selection. The SuperNode algorithm [<xref ref-type="bibr" rid="B27">27</xref>] uses the Blondel community detection algorithm to get the community division in the network, and selects important nodes from the communities according to size so that the selected nodes have some distance. An independent set (IS)-based partitioned ranking algorithm [<xref ref-type="bibr" rid="B20">20</xref>] divides nodes into independent sets by the Welsh-Powell coloring algorithm, then selects the top-ranked nodes in the largest independent set based on certain centrality indicators. The local index rank (LIR) algorithm [<xref ref-type="bibr" rid="B19">19</xref>] selects spreaders from nodes with 0-<italic>LI</italic> values, i.e.,&#x20;those whose direct neighbors have lower degrees than themselves. However, there may not be enough 0-<italic>LI</italic> nodes to be selected as spreaders in some cases, and the selection of adjacent nodes cannot be avoided. We seek to overcome the above deficiencies by extending LIR methods to two-layer neighbors and integrating them with IS methods.</p>
</sec>
<sec id="s3">
<title>3 Methods</title>
<p>We formalize the problem of multiple influential spreader identification and propose the LIR-2, IS-LIR, and IS-LIR-2 algorithms, which consider the diversity of nodes to different degrees.</p>
<sec id="s3-1">
<title>3.1 Formulation of Research Problem</title>
<p>Given a graph <italic>G</italic> (<italic>V</italic>, <italic>E</italic>), where <italic>V</italic>&#x20;&#x3d; {<italic>v</italic>
<sub>1</sub>, <italic>v</italic>
<sub>2</sub>, &#x2026; , <italic>v</italic>
<sub>
<italic>N</italic>
</sub>} denotes the node-set and whose size is <italic>N</italic>, and <italic>E</italic>&#x20;&#x3d; {<italic>e</italic>
<sub>1</sub>, <italic>e</italic>
<sub>2</sub>, &#x2026; , <italic>e</italic>
<sub>
<italic>M</italic>
</sub>} denotes the edge-set, whose size is <italic>M</italic>. A method to address the problem of multiple influential node identification can be regarded as a function <italic>f</italic> (&#x22c5;) to select a node subset <italic>S</italic>&#x20;&#x2286; <italic>V</italic> with a given <italic>k</italic> (1 &#x3c; <italic>k</italic>&#x20;&#x3c; <italic>N</italic>) nodes, which should have the maximum influence on graph <italic>G</italic>, i.e.,&#x20;<inline-formula id="inf1">
<mml:math id="m1">
<mml:mrow>
<mml:mi>S</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mo>&#x2a;</mml:mo>
</mml:mrow>
<mml:mo>&#x3d;</mml:mo>
<mml:munder>
<mml:mrow>
<mml:mi>arg</mml:mi>
<mml:mi>max</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>S</mml:mi>
</mml:mrow>
</mml:munder>
<mml:mi>f</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mi>S</mml:mi>
<mml:mo>,</mml:mo>
<mml:mi>G</mml:mi>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula>.</p>
</sec>
<sec id="s3-2">
<title>3.2&#x20;LIR-2 Method</title>
<p>LIR-2 improves on LIR [<xref ref-type="bibr" rid="B19">19</xref>], where the local index (<italic>LI</italic>) of node <italic>v</italic>
<sub>
<italic>i</italic>
</sub> is the number of its first-order neighbors of greater degree, i.e.,&#x20;<inline-formula id="inf2">
<mml:math id="m2">
<mml:mi>L</mml:mi>
<mml:mi>I</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
<mml:mo>&#x3d;</mml:mo>
<mml:msub>
<mml:mrow>
<mml:mo movablelimits="false" form="prefix">&#x2211;</mml:mo>
</mml:mrow>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>j</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mo>&#x2208;</mml:mo>
<mml:mi>N</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:msub>
<mml:mi>Q</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>d</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>j</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mo>&#x2212;</mml:mo>
<mml:msub>
<mml:mrow>
<mml:mi>d</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:math>
</inline-formula>, where <italic>d</italic>
<sub>
<italic>i</italic>
</sub> is the degree of node <italic>v</italic>
<sub>
<italic>i</italic>
</sub>, <italic>N</italic>(<italic>v</italic>
<sub>
<italic>i</italic>
</sub>) &#x3d; {<italic>v</italic>
<sub>
<italic>j</italic>
</sub>&#x7c;<italic>v</italic>
<sub>
<italic>j</italic>
</sub> &#x2208; <italic>V</italic> (<italic>v</italic>
<sub>
<italic>j</italic>
</sub>, <italic>v</italic>
<sub>
<italic>i</italic>
</sub>) &#x2208; <italic>E</italic>} contains the neighbors of <italic>v</italic>
<sub>
<italic>i</italic>
</sub>, and <italic>Q</italic>(<italic>x</italic>) &#x3d; 1 when <italic>x</italic>&#x20;&#x3e; 0, and otherwise <italic>Q</italic>(<italic>x</italic>) &#x3d; 0. Nodes with <italic>LI</italic> values of zero (i.e.,&#x20;0-<italic>LI</italic> nodes) are ranked by degree, and the top-ranked nodes are selected as spreaders.</p>
<p>LIR-2 extends the neighbors of node <italic>v</italic>
<sub>
<italic>i</italic>
</sub> from first to second order. The second-order local index <italic>LI</italic>
<sub>2</sub> of node <italic>v</italic>
<sub>
<italic>i</italic>
</sub> is defined as<disp-formula id="e1">
<mml:math id="m3">
<mml:mi>L</mml:mi>
<mml:msub>
<mml:mrow>
<mml:mi>I</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mn>2</mml:mn>
</mml:mrow>
</mml:msub>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
<mml:mo>&#x3d;</mml:mo>
<mml:munder>
<mml:mrow>
<mml:mo>&#x2211;</mml:mo>
</mml:mrow>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>k</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mo>&#x2208;</mml:mo>
<mml:mrow>
<mml:mo stretchy="false">{</mml:mo>
<mml:mrow>
<mml:mi>N</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
<mml:mo>&#x222a;</mml:mo>
<mml:mi>N</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mi>N</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
<mml:mo stretchy="false">}</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:munder>
<mml:mi>Q</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>d</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>k</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mo>&#x2212;</mml:mo>
<mml:msub>
<mml:mrow>
<mml:mi>d</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>i</mml:mi>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
<mml:mo>,</mml:mo>
</mml:math>
<label>(1)</label>
</disp-formula>where <italic>N</italic>(<italic>v</italic>
<sub>
<italic>i</italic>
</sub>) and <italic>N</italic> (<italic>N</italic>(<italic>v</italic>
<sub>
<italic>i</italic>
</sub>)) denote the first- and second-order neighbors, respectively, of node <italic>v</italic>
<sub>
<italic>i</italic>
</sub>, <italic>Q</italic>(<italic>x</italic>) &#x3d; 1 when <italic>x</italic>&#x20;&#x3e; 0, and otherwise <italic>Q</italic>(<italic>x</italic>) &#x3d; 0. According to the definition, the <italic>LI</italic>
<sub>2</sub> value of node <italic>v</italic>
<sub>
<italic>i</italic>
</sub> is the number of its first- and second-order neighbors of greater degree.</p>
<p>The LIR-2 method sorts nodes by <italic>LI</italic>
<sub>2</sub> values within degrees, and selects those of top rank as spreaders, as described in <xref ref-type="other" rid="alg1">Algorithm&#x20;1</xref>.</p>
<p>
<statement content-type="algorithm" id="alg1">
<label>Algorithm 1</label>
<p>LIR-2</p>
<p>
<inline-graphic xlink:href="fphy-09-766615-fx1.tif"/>
</p>
<p>
<xref ref-type="fig" rid="F1">Figures 1A,B</xref> illustrate LIR and LIR-2, respectively, on a toy network with 20 nodes and 41 edges. <xref ref-type="fig" rid="F1">Figure&#x20;1C</xref> shows a single 0-<italic>LI</italic> node (node 20). Therefore, 0-<italic>LI</italic> nodes are insufficient for the selection of multiple spreaders. As LIR-2 is not limited to the selection of top-ranked spreaders from nodes with 0&#x20;<italic>LI</italic>
<sub>2</sub> values, they can select spreaders as required.</p>
</statement>
</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption>
<p>Illustrations of LIR [subfigure <bold>(A)</bold>], LIR-2 [subfigure <bold>(B)</bold>], IS-LIR [subfigure <bold>(D)</bold>], and IS-LIR-2 [subfigure <bold>(E)</bold>] methods on a toy network with 20 nodes and 41 edges. The selected spreaders are highlighted in light blue color. Nodes with different colors in subfigures <bold>(D)</bold> and <bold>(E)</bold> belong to different independent sets, which are generated by the Welsh-Powell algorithm. The values of index LI and LI2 of nodes are represented in subfigure <bold>(C)</bold> and subfigure <bold>(F)</bold>.</p>
</caption>
<graphic xlink:href="fphy-09-766615-g001.tif"/>
</fig>
</sec>
<sec id="s3-3">
<title>3.3&#x20;IS-LIR Method</title>
<p>The LIR method cannot avoid the selection of adjacent nodes. We combine LIR with the IS method to ensure that nodes in the same independent set are non-adjacent. The proposed IS-LIR method uses the Welsh-Powell algorithm to divide nodes into different independent sets, then calculates LI for nodes in independent sets that are ranked in descending order. Nodes are selected from the ranked independent sets, one by one, based on the LIR method. The IS-LIR algorithm is outlined in <xref ref-type="other" rid="alg2">Algorithm&#x20;2</xref>.</p>
<p>
<statement content-type="algorithm" id="alg2">
<label>Algorithm 2</label>
<p>IS-LIR</p>
<p>
<inline-graphic xlink:href="fphy-09-766615-fx2.tif"/>
</p>
<p>
<xref ref-type="fig" rid="F1">Figure&#x20;1D</xref> illustrates the IS-LIR method on a toy network as an example, first using the Welsh-Powell algorithm to color all nodes in four colors (blue, green, yellow, and pink). Nodes of the same color constitute independent sets, which are sorted by node size, and nodes are sorted by degree within each independent set. We now have a node list, whose top members are selected as the influential spreaders. For instance, using the IS-SIR method, if we seek three effective spreaders on the toy network, we will select nodes 20, 8, and 1 in the blue&#x20;set.</p>
</statement>
</p>
</sec>
<sec id="s3-4">
<title>3.4 IS-LIR-2 Method</title>
<p>IS-LIR-2 combines IS and LIR-2 to select spreaders from more dispersed candidates. Its process, as shown in <xref ref-type="other" rid="alg3">Algorithm 3</xref>, is similar to that of IS-LIR, but nodes in each independent set are ranked based on <italic>LI</italic>
<sub>2</sub> values.</p>
<p>
<statement content-type="algorithm" id="alg3">
<label>Algorithm 3</label>
<p>IS-LIR-2</p>
<p>
<inline-graphic xlink:href="fphy-09-766615-fx3.tif"/>
</p>
<p>
<xref ref-type="fig" rid="F1">Figure&#x20;1E</xref> illustrates how IS-LIR-2 runs on the toy network. Like the IS-LIR method (<xref ref-type="fig" rid="F1">Figure&#x20;1D</xref>), nodes are colored with four colors. Three spreaders, nodes 20, 8, and 4, are selected according to their <italic>LI</italic>
<sub>2</sub> values, as shown in <xref ref-type="fig" rid="F1">Figure&#x20;1F</xref>.</p>
</statement>
</p>
</sec>
</sec>
<sec id="s4">
<title>4 Experiment Settings</title>
<p>We introduce the classic SIR model, which will be utilized to simulate epidemic spreading, and present two evaluation metrics to compare the performance of the proposed methods with eight baseline methods: degree centrality ranking (DC) [<xref ref-type="bibr" rid="B9">9</xref>], LIR [<xref ref-type="bibr" rid="B19">19</xref>], degree centrality ranking based independent set (IS-DC) [<xref ref-type="bibr" rid="B20">20</xref>], eigenvector centrality ranking based independent set (IS-EV) [<xref ref-type="bibr" rid="B20">20</xref>], neighborhood centrality ranking based independent set (IS-ND) [<xref ref-type="bibr" rid="B20">20</xref>], and VoteRank [<xref ref-type="bibr" rid="B17">17</xref>]. We describe the synthetic and real networks used in our experiments, and discuss parameter settings.</p>
<sec id="s4-1">
<title>4.1 SIR Model</title>
<p>The SIR model classifies each node in a propagation process into&#x20;the three states of susceptible, infected, and recovered. All nodes are initially susceptible, except a few in infected states. In our simulations, the infected nodes at time step <italic>t</italic>&#x20;&#x3d; 0 are those identified as influential nodes by our proposed methods and the baseline methods for comparisons. At each time step, infected nodes at the end of the previous time step randomly select a neighbor node, which, if susceptible, will be infected with probability <italic>&#x3bc;</italic>. All infected nodes recover with probability <italic>&#x3b2;</italic>. Recovered nodes cannot be infected again, and cannot affect susceptible neighbor nodes. Simulations end when there are no infected nodes in the network.</p>
</sec>
<sec id="s4-2">
<title>4.2 Evaluation Metrics</title>
<p>We use two measures to evaluate the performance of our methods in identifying effective influential spreaders. The outbreak size proportion [<xref ref-type="bibr" rid="B28">28</xref>] at time step T is<disp-formula id="e2">
<mml:math id="m4">
<mml:mi>F</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mi>T</mml:mi>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
<mml:mo>&#x3d;</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mi>n</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>R</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mi>T</mml:mi>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:msub>
<mml:mo>&#x2b;</mml:mo>
<mml:msub>
<mml:mrow>
<mml:mi>n</mml:mi>
</mml:mrow>
<mml:mrow>
<mml:mi>I</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mi>T</mml:mi>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:msub>
</mml:mrow>
<mml:mrow>
<mml:mi>N</mml:mi>
</mml:mrow>
</mml:mfrac>
<mml:mo>,</mml:mo>
</mml:math>
<label>(2)</label>
</disp-formula>where <italic>n</italic>
<sub>
<italic>R</italic>(<italic>T</italic>)</sub> and <italic>n</italic>
<sub>
<italic>I</italic>(<italic>T</italic>)</sub> are the numbers of susceptible and infected nodes, respectively, at the end of the time step T, and <italic>N</italic> is the total number of&#x20;nodes.</p>
<p>The average shortest path length of the identified spreaders represents the dispersion among them [<xref ref-type="bibr" rid="B28">28</xref>], and is defined as<disp-formula id="e3">
<mml:math id="m5">
<mml:mi>L</mml:mi>
<mml:mo>&#x3d;</mml:mo>
<mml:mo stretchy="false">&#x7c;</mml:mo>
<mml:mi>S</mml:mi>
<mml:mo stretchy="false">&#x7c;</mml:mo>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mo stretchy="false">&#x7c;</mml:mo>
<mml:mi>S</mml:mi>
<mml:mo stretchy="false">&#x7c;</mml:mo>
<mml:mo>&#x2212;</mml:mo>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
<mml:mfrac>
<mml:mrow>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mrow>
<mml:msub>
<mml:mrow>
<mml:mo movablelimits="false" form="prefix">&#x2211;</mml:mo>
</mml:mrow>
<mml:mrow>
<mml:mi>u</mml:mi>
<mml:mo>,</mml:mo>
<mml:mi>v</mml:mi>
<mml:mo>&#x2208;</mml:mo>
<mml:mi>S</mml:mi>
<mml:mspace width="0.3333em"/>
<mml:mi>u</mml:mi>
<mml:mo>&#x2260;</mml:mo>
<mml:mi>v</mml:mi>
</mml:mrow>
</mml:msub>
<mml:mfrac>
<mml:mrow>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mrow>
<mml:mi>l</mml:mi>
<mml:mrow>
<mml:mo stretchy="false">(</mml:mo>
<mml:mrow>
<mml:mi>u</mml:mi>
<mml:mo>,</mml:mo>
<mml:mi>v</mml:mi>
</mml:mrow>
<mml:mo stretchy="false">)</mml:mo>
</mml:mrow>
</mml:mrow>
</mml:mfrac>
</mml:mrow>
</mml:mfrac>
<mml:mo>,</mml:mo>
<mml:mspace width="0.3333em"/>
</mml:math>
<label>(3)</label>
</disp-formula>where <italic>l</italic> (<italic>u</italic>, <italic>v</italic>) is the shortest path length between nodes <italic>u</italic> and <italic>v</italic>; when &#x7c;<italic>S</italic>&#x7c; &#x3d; 1, <italic>L</italic>&#x20;&#x3d; 0. A larger <italic>L</italic> indicates a smaller overlapping neighbor area between nodes in the spreader&#x20;set.</p>
</sec>
<sec id="s4-3">
<title>4.3 Synthetic and Real Networks</title>
<p>To evaluate the effectiveness of our proposed methods in identifying influential spreaders on networks with different topological structures, we compare them with benchmark algorithms on 10 synthetic networks and four real networks. The synthetic networks include three small-world networks generated based on the <italic>Watts</italic>-<italic>Strogtaz</italic> (WS) small-world network model [<xref ref-type="bibr" rid="B29">29</xref>], four scale-free networks generated based on the <inline-formula id="inf3">
<mml:math id="m6">
<mml:mi>B</mml:mi>
<mml:mi>a</mml:mi>
<mml:mi>r</mml:mi>
<mml:mi>a</mml:mi>
<mml:mi>b</mml:mi>
<mml:mrow>
<mml:mover accent="true">
<mml:mrow>
<mml:mi>a</mml:mi>
</mml:mrow>
<mml:mo>&#x301;</mml:mo>
</mml:mover>
</mml:mrow>
<mml:mi>s</mml:mi>
<mml:mi>i</mml:mi>
</mml:math>
</inline-formula>-<italic>Albert</italic> scale-free network model [<xref ref-type="bibr" rid="B30">30</xref>], and three networks with community structures generated by the LFR community network model [<xref ref-type="bibr" rid="B31">31</xref>]. <xref ref-type="table" rid="T1">Table&#x20;1</xref> presents key parameter settings for the 10 synthetic networks, and <xref ref-type="table" rid="T2">Table&#x20;2</xref> summarizes their basic topological features.</p>
<table-wrap id="T1" position="float">
<label>TABLE 1</label>
<caption>
<p>Key parameter settings in generating synthetic networks. <italic>N</italic> is the number of nodes; <italic>p</italic> is a random reconnection probability; <inline-formula id="inf4">
<mml:math id="m7">
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:math>
</inline-formula> is the average degree; <italic>m</italic> is the number of new edges in every iteration; <italic>&#x3c4;</italic>1 is the exponent of the degree sequence; <italic>&#x3c4;</italic>2 is the exponent of the community size distribution; <italic>&#x3bc;</italic> is a mixing parameter that is the average ratio of the external and total degrees; <italic>MD</italic> is the maximum degree of the network.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Network</th>
<th align="center">
<italic>N</italic>
</th>
<th align="center">
<italic>P</italic>
</th>
<th align="center">
<inline-formula id="inf5">
<mml:math id="m8">
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:math>
</inline-formula>
</th>
<th align="center">
<italic>m</italic>
</th>
<th align="center">
<italic>&#x3c4;</italic>1</th>
<th align="center">
<italic>&#x3c4;</italic>2</th>
<th align="center">
<italic>&#x3bc;</italic>
</th>
<th align="center">
<italic>MD</italic>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">WS1</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">0.001</td>
<td align="char" char=".">4</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
</tr>
<tr>
<td align="left">WS2</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">0.01</td>
<td align="char" char=".">4</td>
<td align="center">&#x2014;</td>
<td align="left"/>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
</tr>
<tr>
<td align="left">WS3</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">0.1</td>
<td align="char" char=".">4</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="left"/>
</tr>
<tr>
<td align="left">BA1</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">1</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
</tr>
<tr>
<td align="left">BA2</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">2</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
</tr>
<tr>
<td align="left">BA3</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">3</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
</tr>
<tr>
<td align="left">BA4</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">4</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
<td align="center">&#x2014;</td>
</tr>
<tr>
<td align="left">LFR1</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">6</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">&#x2212;2.5</td>
<td align="char" char=".">&#x2212;2.5</td>
<td align="char" char=".">0.1</td>
<td align="char" char=".">50</td>
</tr>
<tr>
<td align="left">LFR2</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">6</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">&#x2212;2.5</td>
<td align="char" char=".">&#x2212;2.5</td>
<td align="char" char=".">0.3</td>
<td align="char" char=".">50</td>
</tr>
<tr>
<td align="left">LFR3</td>
<td align="char" char=".">5,000</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">6</td>
<td align="center">&#x2014;</td>
<td align="char" char=".">&#x2212;2.5</td>
<td align="char" char=".">&#x2212;2.5</td>
<td align="char" char=".">0.5</td>
<td align="char" char=".">50</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="T2" position="float">
<label>TABLE 2</label>
<caption>
<p>Topological features of synthetic networks. <italic>N</italic> is the number of nodes; <italic>M</italic> is the number of edges; <inline-formula id="inf6">
<mml:math id="m9">
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:math>
</inline-formula> is the average degree; <italic>L</italic> is the average shortest path length; <italic>D</italic> is the network diameter; <italic>C</italic> is the average clustering coefficient.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Network</th>
<th align="center">N</th>
<th align="center">M</th>
<th align="center">
<inline-formula id="inf7">
<mml:math id="m10">
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:math>
</inline-formula>
</th>
<th align="center">L</th>
<th align="center">D</th>
<th align="center">C</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">WS1</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">10,000</td>
<td align="char" char=".">4</td>
<td align="char" char=".">192.677</td>
<td align="char" char=".">536</td>
<td align="char" char=".">0.498</td>
</tr>
<tr>
<td align="left">WS2</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">10,000</td>
<td align="char" char=".">4</td>
<td align="char" char=".">43.25</td>
<td align="char" char=".">117</td>
<td align="char" char=".">0.487</td>
</tr>
<tr>
<td align="left">WS3</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">10,000</td>
<td align="char" char=".">4</td>
<td align="char" char=".">11.295</td>
<td align="char" char=".">22</td>
<td align="char" char=".">0.37</td>
</tr>
<tr>
<td align="left">BA1</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">4,999</td>
<td align="char" char=".">2</td>
<td align="char" char=".">7.756</td>
<td align="char" char=".">20</td>
<td align="char" char=".">0</td>
</tr>
<tr>
<td align="left">BA2</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">9,996</td>
<td align="char" char=".">3.998</td>
<td align="char" char=".">4.768</td>
<td align="char" char=".">8</td>
<td align="char" char=".">0.008</td>
</tr>
<tr>
<td align="left">BA3</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">14,991</td>
<td align="char" char=".">5.996</td>
<td align="char" char=".">4.502</td>
<td align="char" char=".">7</td>
<td align="char" char=".">0.01</td>
</tr>
<tr>
<td align="left">BA4</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">19,984</td>
<td align="char" char=".">7.994</td>
<td align="char" char=".">3.663</td>
<td align="char" char=".">6</td>
<td align="char" char=".">0.0011</td>
</tr>
<tr>
<td align="left">LFR1</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">14,535</td>
<td align="char" char=".">5.841</td>
<td align="char" char=".">7.47</td>
<td align="char" char=".">21</td>
<td align="char" char=".">0.575</td>
</tr>
<tr>
<td align="left">LFR2</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">15,091</td>
<td align="char" char=".">6.036</td>
<td align="char" char=".">5.232</td>
<td align="char" char=".">11</td>
<td align="char" char=".">0.319</td>
</tr>
<tr>
<td align="left">LFR3</td>
<td align="char" char=".">5,000</td>
<td align="char" char=".">14,613</td>
<td align="char" char=".">5.845</td>
<td align="char" char=".">4.769</td>
<td align="char" char=".">9</td>
<td align="char" char=".">0.116</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>The five real networks used in this study include a football network [<xref ref-type="bibr" rid="B32">32</xref>], a collaboration network [<xref ref-type="bibr" rid="B33">33</xref>] between jazz musicians (referred to as jazz network), a contact network between high school students (referred to as high-school network) [<xref ref-type="bibr" rid="B34">34</xref>], an email network [<xref ref-type="bibr" rid="B35">35</xref>], and a power network [<xref ref-type="bibr" rid="B29">29</xref>]. The football network includes United&#x20;States college Division I football games in 2000, where nodes represent teams, and edges are regular-season games between two connected teams [<xref ref-type="bibr" rid="B32">32</xref>]. The jazz network describes collaborations between jazz musicians, where each node represents a jazz musician, and an edge denotes that two musicians have played together in a band. The high-school network shows contacts between high school students in specific classes (called &#x201c;classes pr&#xe9;paratoires&#x201d; in Lyc&#xe9;e Thiers, France). The email network presents email communications at the University Rovira i Virgili in Tarragona, Spain, in 2003. Nodes are users, and each edge represents that at least one email was sent. The power network is a topological representation of the Western States Power Grid in the United&#x20;States, where an edge denotes a power supply line and a node can be a generator, transformer, or substation. <xref ref-type="table" rid="T3">Table&#x20;3</xref> summarizes the basic topological features of the five real networks.</p>
<table-wrap id="T3" position="float">
<label>TABLE 3</label>
<caption>
<p>Basic topological features of five real networks. N is the number of nodes; M is the number of edges; <inline-formula id="inf8">
<mml:math id="m11">
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:math>
</inline-formula> is the average degree; L is the average shortest path length; D is the network diameter; C is the average clustering coefficient.</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Network</th>
<th align="center">N</th>
<th align="center">M</th>
<th align="center">
<inline-formula id="inf9">
<mml:math id="m12">
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:math>
</inline-formula>
</th>
<th align="center">L</th>
<th align="center">D</th>
<th align="center">C</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">Football</td>
<td align="char" char=".">115</td>
<td align="char" char=".">613</td>
<td align="char" char=".">10.661</td>
<td align="char" char=".">2.508</td>
<td align="char" char=".">4</td>
<td align="char" char=".">0.403</td>
</tr>
<tr>
<td align="left">arenas-jazz</td>
<td align="char" char=".">198</td>
<td align="char" char=".">2,742</td>
<td align="char" char=".">27.679</td>
<td align="char" char=".">2.235</td>
<td align="char" char=".">6</td>
<td align="char" char=".">0.633</td>
</tr>
<tr>
<td align="left">hschool0</td>
<td align="char" char=".">312</td>
<td align="char" char=".">2,242</td>
<td align="char" char=".">14.37</td>
<td align="char" char=".">2</td>
<td align="char" char=".">5</td>
<td align="char" char=".">0.4</td>
</tr>
<tr>
<td align="left">arenas-email</td>
<td align="char" char=".">1,133</td>
<td align="char" char=".">5,451</td>
<td align="char" char=".">9.62</td>
<td align="char" char=".">3.606</td>
<td align="char" char=".">8</td>
<td align="char" char=".">0.254</td>
</tr>
<tr>
<td align="left">Power</td>
<td align="char" char=".">4,941</td>
<td align="char" char=".">6,594</td>
<td align="char" char=".">2.669</td>
<td align="char" char=".">18.989</td>
<td align="char" char=".">46</td>
<td align="char" char=".">0.107</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="s4-4">
<title>4.4 Parameter Settings</title>
<p>Our experiments based on the SIR model explored the proportion of final outbreak size <italic>F</italic> (<italic>t</italic>
<sub>
<italic>end</italic>
</sub>) with respect to the effective infected probability <italic>&#x3bb;</italic> and proportion of spreaders <italic>p</italic>. We set the parameter of the recovered probability <inline-formula id="inf10">
<mml:math id="m13">
<mml:mi>&#x3b2;</mml:mi>
<mml:mo>&#x3d;</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mrow>
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:mrow>
</mml:mfrac>
</mml:math>
</inline-formula> used by He et&#x20;al.&#x20;[<xref ref-type="bibr" rid="B27">27</xref>].</p>
<p>We also carried out a sensitivity analysis on the size of the spreader set <italic>p</italic>, varying it between 0.01 and 0.15, i.e.,&#x20;<italic>p</italic>&#x20;&#x2208; [0.01, 0.15], with a step of 0.01, and the effective infected probability <italic>&#x3bb;</italic> was fixed at&#x20;2.0.</p>
<p>In addition, we explored the final outbreak size proportion <italic>F</italic> (<italic>t</italic>
<sub>
<italic>end</italic>
</sub>) while varying the effective infected probability <italic>&#x3bb;</italic>, where <italic>&#x3bb;</italic> &#x2208; [1.5, 2.5] with a step of 0.1, and fixed the scales of spreaders at <italic>p</italic>&#x20;&#x3d; 0.08. Results were averaged over 1,000 independent&#x20;runs.</p>
</sec>
</sec>
<sec sec-type="results|discussion" id="s5">
<title>5 Results and Discussion</title>
<p>We present the experimental results evaluating the proposed methods, and determine whether identified spreaders are effective while varying the infection probability <italic>&#x3bb;</italic>. We show the relationships between the dispersion and the effectiveness of influential spreaders identified by our proposed methods and the baseline methods.</p>
<p>
<xref ref-type="fig" rid="F2">Figure&#x20;2</xref> displays the final outbreak size <italic>F</italic> (<italic>t</italic>
<sub>
<italic>end</italic>
</sub>) for different numbers of spreaders (denoted by the proportion of selected spreaders <italic>p</italic>) identified by different methods based on SIR simulations, and shows that our proposed methods generally outperform the baseline methods on synthetic and real networks. On WS networks, IS-LIR-2 has the largest final outbreak scale on WS1. IS-LIR-2, IS-LIR, and VoteRank perform similarly to or better than other algorithms on WS2 and WS3. On BA networks, the performance of IS-LIR-2 and LIR-2 is superior to the other methods, especially on BA2, BA3, and BA4. On LFR networks, IS-LIR performs better than the other methods, and IS-LIR-2 performs better on LFR2 but not so well on LFR3. In experiments on real networks, IS-LIR and IS-LIR2 could identify more influential spreaders in most cases on almost all five real networks. However, LIR-2 was not significantly superior on real networks except the arenas-email network. LIR-2, IS-LIR, and IS-LIR2 had obvious advantages selecting multiple spreaders in most cases. This implies that to take into account the dispersion of selected nodes can improve performance.</p>
<fig id="F2" position="float">
<label>FIGURE 2</label>
<caption>
<p>Proportion of final outbreak size <italic>F</italic> (<italic>t</italic>
<sub>
<italic>end</italic>
</sub>) with respect to different proportions <italic>p</italic> of selected spreaders with respect to nine algorithms on 10 synthetic networks [subfigures <bold>(A&#x2013;J)</bold>] and five real networks [subfigures <bold>(K&#x2013;O)</bold>]. Infected probability in SIR model is <italic>&#x3bb;</italic> &#x3d; 2.0; SIR recovered probability <inline-formula id="inf11">
<mml:math id="m14">
<mml:mi>&#x3b2;</mml:mi>
<mml:mo>&#x3d;</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mrow>
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:mrow>
</mml:mfrac>
</mml:math>
</inline-formula> and results are averaged over 1,000 independent&#x20;runs.</p>
</caption>
<graphic xlink:href="fphy-09-766615-g002.tif"/>
</fig>
<p>As the infected probability in the SIR model is a key parameter that may affect the final break size of infections, we explored the performance (represented by the final outbreak size proportion <italic>F</italic> (<italic>t</italic>
<sub>
<italic>end</italic>
</sub>)) of our proposed methods with different values of the infected probability <italic>&#x3bb;</italic>. As shown in <xref ref-type="fig" rid="F3">Figure&#x20;3</xref>, whether <italic>&#x3bb;</italic> is small or large, IS-LIR and IS-LIR-2 have significant advantages over baseline methods on most of the synthetic and real networks. Specifically, on WS networks, as the infected rate increases, the performance of IS-LIR-2 increases significantly on WS1 and WS2, and IS-LIR performs best on WS2. On BA networks, IS-LIR-2 and LIR-2 are consistently superior to other algorithms on most BA networks. Focusing on LFR networks, we can see that IS-LIR is always better than the baseline methods except on the LFR2 network, where IS-LIR-2 performs better. On real networks, we can see that IS-LIR and IS-LIR-2 maintain their advantages whether <italic>&#x3bb;</italic> is small or&#x20;large.</p>
<fig id="F3" position="float">
<label>FIGURE 3</label>
<caption>
<p>Final outbreak size proportion <italic>F</italic> (<italic>t</italic>
<sub>
<italic>end</italic>
</sub>) at different effective infected probabilities <italic>&#x3bb;</italic> with respect to nine algorithms on ten synthetic networks [subfigures <bold>(A&#x2013;J)</bold>] and five real networks [subfigures <bold>(K&#x2013;O)</bold>]. SIR recovered probability <inline-formula id="inf12">
<mml:math id="m15">
<mml:mi>&#x3b2;</mml:mi>
<mml:mo>&#x3d;</mml:mo>
<mml:mfrac>
<mml:mrow>
<mml:mn>1</mml:mn>
</mml:mrow>
<mml:mrow>
<mml:mo>&#x3c;</mml:mo>
<mml:mi>k</mml:mi>
<mml:mo>&#x3e;</mml:mo>
</mml:mrow>
</mml:mfrac>
</mml:math>
</inline-formula>, proportion of spreaders <italic>p</italic>&#x20;&#x3d; 0.08, and results are averaged over 1,000 independent&#x20;runs.</p>
</caption>
<graphic xlink:href="fphy-09-766615-g003.tif"/>
</fig>
<p>
<xref ref-type="fig" rid="F4">Figure&#x20;4</xref> presents the structural characteristics of influential nodes identified by LIR-2, IS-LIR, and IS-LIR2 and the baseline methods, and shows that spreaders identified by IS-LIR-2, IS-LIR, and LIR-2 have the largest harmonic mean of the average shortest path length <italic>L</italic> between any two nodes in most cases, except the LFR3 and football networks. On LFR3, multiple spreaders identified by IS-LIR, IS-ND, and IS-EV have the top three average shortest path lengths (as shown in <xref ref-type="fig" rid="F4">Figure&#x20;4J</xref>). On the football network, vote-rank and IS-DC identified spreaders with larger average shortest path lengths than our proposed method in a few cases (as shown in <xref ref-type="fig" rid="F4">Figure&#x20;4K</xref>). These results may explain why our proposed methods outperform the baseline methods in identifying multiple influential spreaders (as shown in <xref ref-type="fig" rid="F2">Figure&#x20;2</xref>): if the identified spreaders have a larger mean shortest path length, they may result in a more heavier infection spreading. This implies that taking into account the dispersion of nodes can help find the most influential spreaders.</p>
<fig id="F4" position="float">
<label>FIGURE 4</label>
<caption>
<p>Harmonic mean of average shortest path length <italic>L</italic> between any two nodes with respect to different proportions of multiple spreaders <italic>p</italic> with respect to nine algorithms on ten synthetic networks [subfigures <bold>(A&#x2013;J)</bold>] and five real networks [subfigures <bold>(K&#x2013;O)</bold>].</p>
</caption>
<graphic xlink:href="fphy-09-766615-g004.tif"/>
</fig>
</sec>
<sec id="s6">
<title>6 Conclusion</title>
<p>To effectively identify a set of influential spreaders is important in infectious disease prevention or information dissemination. To address this problem, inspired by the LIR method [<xref ref-type="bibr" rid="B19">19</xref>] and IS method [<xref ref-type="bibr" rid="B20">20</xref>], we proposed the LIR-2, IS-LIR, IS-LIR-2 algorithms, which take into account the dispersion of selected spreaders in different ways. In evaluation experiments on 10 synthetic networks and five real networks, our proposed methods, especially IS-LIR and IS-LIR-2, were more effective than six baseline methods at identifying more influential spreaders. One potential reason is that the spreaders found by our methods have a larger average shortest path length, i.e.,&#x20;the selected spreaders are more dispersed, so as to reduce the opportunity to infect the same nodes in the propagation process. IS-LIR, LIR-2, and IS-LIR-2 achieved a good balance between expanding the final spreading range of the spreaders on the SIR model and increasing the topological distance between them. However, we merely studied static, undirected, and unweighted networks. How to extend our methods to other types of networks, and how to investigate their sensitivity to specific network characteristics are two interesting questions to be addressed in future&#x20;work.</p>
</sec>
</body>
<back>
<sec id="s7">
<title>Data Availability Statement</title>
<p>The data used in the study are all available <italic>via</italic> the cited references, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec id="s8">
<title>Author Contributions</title>
<p>Proposed and implemented algorithms: LT, ML, and LL. Performed the experiments: LT, ML, and LL. Wrote the paper: LT, ML, ZZ, and&#x20;LL.</p>
</sec>
<sec id="s9">
<title>Funding</title>
<p>This work is supported by National Natural Science Foundation of China (No. 61976181) and Fundamental Research Funds for the Central Universities (XDJK2019C122).</p>
</sec>
<sec sec-type="COI-statement" id="s10">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s11">
<title>Publisher&#x2019;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<ref-list>
<title>References</title>
<ref id="B1">
<label>1.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Su</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Gao</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Jia</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Kurths</surname>
<given-names>J</given-names>
</name>
</person-group>. <article-title>Emergence of Nonlinear Crossover under Epidemic Dynamics in Heterogeneous Networks</article-title>. <source>Phys Rev E</source> (<year>2020</year>) <volume>102</volume>:<fpage>052311</fpage>. <pub-id pub-id-type="doi">10.1103/PhysRevE.102.052311</pub-id> </citation>
</ref>
<ref id="B2">
<label>2.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gao</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Su</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Kurths</surname>
<given-names>J</given-names>
</name>
</person-group>. <article-title>Even central Users Do Not Always Drive Information Diffusion</article-title>. <source>Commun ACM</source> (<year>2019</year>) <volume>62</volume>:<fpage>61</fpage>&#x2013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1145/3224203</pub-id> </citation>
</ref>
<ref id="B3">
<label>3.</label>
<citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname>Kempe</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Kleinberg</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Tardos</surname>
<given-names>&#xc9;</given-names>
</name>
</person-group>. <article-title>Maximizing the Spread of Influence through a Social Network</article-title>. In: <conf-name>Proceedings of the Ninth ACM SIGKDD International Conference on Knowledge Discovery and Data Mining-KDD &#x2019;03</conf-name>; <conf-date>2003 August 24&#x2013;27</conf-date>; <conf-loc>Washington, D.C.</conf-loc> <publisher-loc>New York, NY, USA</publisher-loc> (<year>2003</year>). p. <fpage>137</fpage>&#x2013;<lpage>46</lpage>. <pub-id pub-id-type="doi">10.1145/956750.956769</pub-id> </citation>
</ref>
<ref id="B4">
<label>4.</label>
<citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname>Chen</surname>
<given-names>W</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Yang</surname>
<given-names>S</given-names>
</name>
</person-group>. <article-title>Efficient Influence Maximization in Social Networks</article-title>. In: <conf-name>Proceedings of the 15th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining-KDD &#x2019;09</conf-name>; <conf-date>2009 June 28&#x2013;July 1</conf-date>; <conf-name>Paris, France</conf-name>. <publisher-loc>New York, NY, USA</publisher-loc> (<year>2009</year>). p. <fpage>199</fpage>&#x2013;<lpage>208</lpage>. <pub-id pub-id-type="doi">10.1145/1557019.1557047</pub-id> </citation>
</ref>
<ref id="B5">
<label>5.</label>
<citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Cong</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Song</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Xie</surname>
<given-names>K</given-names>
</name>
</person-group>. <article-title>Community-based Greedy Algorithm for Mining Top-K Influential Nodes in mobile Social Networks</article-title>. In: <conf-name>Proceedings of the 16th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining KDD &#x2019;10</conf-name>; <conf-date>2010 July 24&#x2013;28</conf-date>; <conf-loc>Washington, D.C.</conf-loc> <publisher-loc>New York, NY, USA</publisher-loc> (<year>2010</year>). p. <fpage>1039</fpage>&#x2013;<lpage>48</lpage>. <pub-id pub-id-type="doi">10.1145/1835804.1835935</pub-id> </citation>
</ref>
<ref id="B6">
<label>6.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zhang</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Zhu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>Q</given-names>
</name>
<name>
<surname>Zhao</surname>
<given-names>H</given-names>
</name>
</person-group>. <article-title>Identifying Influential Nodes in Complex Networks with Community Structure</article-title>. <source>Knowledge-Based Syst</source> (<year>2013</year>) <volume>42</volume>:<fpage>74</fpage>&#x2013;<lpage>84</lpage>. <pub-id pub-id-type="doi">10.1016/j.knosys.2013.01.017</pub-id> </citation>
</ref>
<ref id="B7">
<label>7.</label>
<citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname>Tang</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Xiao</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Shi</surname>
<given-names>Y</given-names>
</name>
</person-group>. <article-title>Influence Maximization</article-title>. In: <conf-name>Proceedings of the 2014 ACM SIGMOD International Conference on Management of Data SIGMOD &#x2019;14</conf-name>; <conf-date>2014 June 22&#x2013;27</conf-date>; <conf-loc>Snowbird, UT</conf-loc>. <publisher-loc>New York, NY, USA</publisher-loc> (<year>2014</year>). p. <fpage>75</fpage>&#x2013;<lpage>86</lpage>. <pub-id pub-id-type="doi">10.1145/2588555.2593670</pub-id> </citation>
</ref>
<ref id="B8">
<label>8.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Morone</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Makse</surname>
<given-names>HA</given-names>
</name>
</person-group>. <article-title>Influence Maximization in Complex Networks through Optimal Percolation</article-title>. <source>Nature</source> (<year>2015</year>) <volume>524</volume>:<fpage>65</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1038/nature14604</pub-id> </citation>
</ref>
<ref id="B9">
<label>9.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bonacich</surname>
<given-names>P</given-names>
</name>
</person-group>. <article-title>Factoring and Weighting Approaches to Status Scores and Clique Identification</article-title>. <source>J&#x20;Math Sociol</source> (<year>1972</year>) <volume>2</volume>:<fpage>113</fpage>&#x2013;<lpage>20</lpage>. <pub-id pub-id-type="doi">10.1080/0022250X.1972.9989806</pub-id> </citation>
</ref>
<ref id="B10">
<label>10.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Freeman</surname>
<given-names>LC</given-names>
</name>
</person-group>. <article-title>Centrality in Social Networks Conceptual Clarification</article-title>. <source>Social Networks</source> (<year>1978</year>) <volume>1</volume>:<fpage>215</fpage>&#x2013;<lpage>39</lpage>. <pub-id pub-id-type="doi">10.1016/0378-8733(78)90021-7</pub-id> </citation>
</ref>
<ref id="B11">
<label>11.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chen</surname>
<given-names>D-B</given-names>
</name>
<name>
<surname>Xiao</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Zeng</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>Y-C</given-names>
</name>
</person-group>. <article-title>Path Diversity Improves the Identification of Influential Spreaders</article-title>. <source>EPL</source> (<year>2014</year>) <volume>104</volume>:<fpage>68006</fpage>. <pub-id pub-id-type="doi">10.1209/0295-5075/104/68006</pub-id> </citation>
</ref>
<ref id="B12">
<label>12.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Du</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Deng</surname>
<given-names>Y</given-names>
</name>
</person-group>. <article-title>A New Measure of Identifying Influential Nodes: Efficiency Centrality</article-title>. <source>Commun Nonlinear Sci Numer Simul</source> (<year>2017</year>) <volume>47</volume>:<fpage>151</fpage>&#x2013;<lpage>63</lpage>. <pub-id pub-id-type="doi">10.1016/j.cnsns.2016.11.008</pub-id> </citation>
</ref>
<ref id="B13">
<label>13.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bian</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Hu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Deng</surname>
<given-names>Y</given-names>
</name>
</person-group>. <article-title>Identifying Influential Nodes in Complex Networks Based on AHP</article-title>. <source>Phys A: Stat Mech Appl</source> (<year>2017</year>) <volume>479</volume>:<fpage>422</fpage>&#x2013;<lpage>36</lpage>. <pub-id pub-id-type="doi">10.1016/j.physa.2017.02.085</pub-id> </citation>
</ref>
<ref id="B14">
<label>14.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Li</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Sun</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Xia</surname>
<given-names>C</given-names>
</name>
</person-group>. <article-title>Identification of Influential Spreaders Based on Classified Neighbors in Real-World Complex Networks</article-title>. <source>Appl Maths Comput</source> (<year>2018</year>) <volume>320</volume>:<fpage>512</fpage>&#x2013;<lpage>23</lpage>. <pub-id pub-id-type="doi">10.1016/j.amc.2017.10.001</pub-id> </citation>
</ref>
<ref id="B15">
<label>15.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Brin</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Page</surname>
<given-names>L</given-names>
</name>
</person-group>. <article-title>The Anatomy of a Large-Scale Hypertextual Web Search Engine</article-title>. <source>Comput Networks ISDN Syst</source> (<year>1998</year>) <volume>30</volume>:<fpage>107</fpage>&#x2013;<lpage>17</lpage>. <pub-id pub-id-type="doi">10.1016/S0169-7552(98)00110-X</pub-id> </citation>
</ref>
<ref id="B16">
<label>16.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>L&#xfc;</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>Y-C</given-names>
</name>
<name>
<surname>Yeung</surname>
<given-names>CH</given-names>
</name>
<name>
<surname>Zhou</surname>
<given-names>T</given-names>
</name>
</person-group>. <article-title>Leaders in Social Networks, the Delicious Case</article-title>. <source>PLoS One</source> (<year>2011</year>) <volume>6</volume>:<fpage>e21202</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0021202</pub-id> </citation>
</ref>
<ref id="B17">
<label>17.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zhang</surname>
<given-names>J-X</given-names>
</name>
<name>
<surname>Chen</surname>
<given-names>D-B</given-names>
</name>
<name>
<surname>Dong</surname>
<given-names>Q</given-names>
</name>
<name>
<surname>Zhao</surname>
<given-names>Z-D</given-names>
</name>
</person-group>. <article-title>Identifying a Set of Influential Spreaders in Complex Networks</article-title>. <source>Sci Rep</source> (<year>2016</year>) <volume>6</volume>:<fpage>27823</fpage>. <pub-id pub-id-type="doi">10.1038/srep27823</pub-id> </citation>
</ref>
<ref id="B18">
<label>18.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Saram&#xe4;ki</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Holme</surname>
<given-names>P</given-names>
</name>
</person-group>. <article-title>Ranking Influential Spreaders Is an Ill-Defined Problem</article-title>. <source>EPL</source> (<year>2017</year>) <volume>118</volume>:<fpage>68002</fpage>. <pub-id pub-id-type="doi">10.1209/0295-5075/118/68002</pub-id> </citation>
</ref>
<ref id="B19">
<label>19.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Liu</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Jing</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Zhao</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>W</given-names>
</name>
<name>
<surname>Song</surname>
<given-names>G</given-names>
</name>
</person-group>. <article-title>A Fast and Efficient Algorithm for Mining Top-K Nodes in Complex Networks</article-title>. <source>Sci Rep</source> (<year>2017</year>) <volume>7</volume>:<fpage>43330</fpage>. <pub-id pub-id-type="doi">10.1038/srep43330</pub-id> </citation>
</ref>
<ref id="B20">
<label>20.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Zhao</surname>
<given-names>X-Y</given-names>
</name>
<name>
<surname>Huang</surname>
<given-names>B</given-names>
</name>
<name>
<surname>Tang</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>H-F</given-names>
</name>
<name>
<surname>Chen</surname>
<given-names>D-B</given-names>
</name>
</person-group>. <article-title>Identifying Effective Multiple Spreaders by Coloring Complex Networks</article-title>. <source>EPL</source> (<year>2015</year>) <volume>108</volume>:<fpage>68005</fpage>. <pub-id pub-id-type="doi">10.1209/0295-5075/108/68005</pub-id> </citation>
</ref>
<ref id="B21">
<label>21.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Li</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Zhao</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Tian</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>Z</given-names>
</name>
</person-group>. <article-title>Functional Immunization of Networks Based on Message Passing</article-title>. <source>Appl Maths Comput</source> (<year>2020</year>) <volume>366</volume>:<fpage>124728</fpage>. <pub-id pub-id-type="doi">10.1016/j.amc.2019.124728</pub-id> </citation>
</ref>
<ref id="B22">
<label>22.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Yu</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Long</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Chen</surname>
<given-names>CLP</given-names>
</name>
<name>
<surname>Wang</surname>
<given-names>Z</given-names>
</name>
</person-group>. <article-title>Adaptive Swarm Control within Saturated Input Based on Nonlinear Coupling Degree</article-title>. <source>IEEE Trans Syst Man Cybern Syst</source> (<year>2021</year>) <fpage>1</fpage>&#x2013;<lpage>12</lpage>. <pub-id pub-id-type="doi">10.1109/TSMC.2021.3102587</pub-id> </citation>
</ref>
<ref id="B23">
<label>23.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gao</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Fan</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Jiang</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Deng</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Liu</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>X</given-names>
</name>
</person-group>. <article-title>Dynamic Robustness Analysis of a Two-Layer Rail Transit Network Model</article-title>. <source>IEEE Trans Intell Transport Syst</source> (<year>2021</year>) <fpage>1</fpage>&#x2013;<lpage>16</lpage>. <pub-id pub-id-type="doi">10.1109/TITS.2021.3058185</pub-id> </citation>
</ref>
<ref id="B24">
<label>24.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Li</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Lu</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Wu</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Han</surname>
<given-names>W</given-names>
</name>
<name>
<surname>Zhao</surname>
<given-names>D</given-names>
</name>
</person-group>. <article-title>Enhancing the Power Grid Robustness against Cascading Failures under Node-Based Attacks</article-title>. <source>Mod Phys Lett B</source> (<year>2021</year>) <volume>35</volume>:<fpage>2150152</fpage>. <pub-id pub-id-type="doi">10.1142/s0217984921501529</pub-id> </citation>
</ref>
<ref id="B25">
<label>25.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kitsak</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Gallos</surname>
<given-names>LK</given-names>
</name>
<name>
<surname>Havlin</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Liljeros</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Muchnik</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Stanley</surname>
<given-names>HE</given-names>
</name>
<etal/>
</person-group> <article-title>Identification of Influential Spreaders in Complex Networks</article-title>. <source>Nat Phys</source> (<year>2010</year>) <volume>6</volume>:<fpage>888</fpage>&#x2013;<lpage>93</lpage>. <pub-id pub-id-type="doi">10.1038/nphys1746</pub-id> </citation>
</ref>
<ref id="B26">
<label>26.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gao</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Zhong</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Li</surname>
<given-names>X</given-names>
</name>
<name>
<surname>Zhang</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Shi</surname>
<given-names>N</given-names>
</name>
</person-group>. <article-title>Combination Methods for Identifying Influential Nodes in Networks</article-title>. <source>Int J&#x20;Mod Phys C</source> (<year>2015</year>) <volume>26</volume>:<fpage>1550067</fpage>. <pub-id pub-id-type="doi">10.1142/S0129183115500679</pub-id> </citation>
</ref>
<ref id="B27">
<label>27.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>He</surname>
<given-names>J-L</given-names>
</name>
<name>
<surname>Fu</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Chen</surname>
<given-names>D-B</given-names>
</name>
</person-group>. <article-title>A Novel Top-K Strategy for Influence Maximization in Complex Networks with Community Structure</article-title>. <source>PLoS One</source> (<year>2015</year>) <volume>10</volume>:<fpage>e0145283</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0145283</pub-id> </citation>
</ref>
<ref id="B28">
<label>28.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Sun</surname>
<given-names>H-l.</given-names>
</name>
<name>
<surname>Chen</surname>
<given-names>D-b.</given-names>
</name>
<name>
<surname>He</surname>
<given-names>J-l.</given-names>
</name>
<name>
<surname>Ch&#x2019;ng</surname>
<given-names>E</given-names>
</name>
</person-group>. <article-title>A Voting Approach to Uncover Multiple Influential Spreaders on Weighted Networks</article-title>. <source>Physica A: Stat Mech its Appl</source> (<year>2019</year>) <volume>519</volume>:<fpage>303</fpage>&#x2013;<lpage>12</lpage>. <pub-id pub-id-type="doi">10.1016/j.physa.2018.12.001</pub-id> </citation>
</ref>
<ref id="B29">
<label>29.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Watts</surname>
<given-names>DJ</given-names>
</name>
<name>
<surname>Strogatz</surname>
<given-names>SH</given-names>
</name>
</person-group>. <article-title>Collective Dynamics of &#x27;small-World&#x27; Networks</article-title>. <source>Nature</source> (<year>1998</year>) <volume>393</volume>:<fpage>440</fpage>&#x2013;<lpage>2</lpage>. <pub-id pub-id-type="doi">10.1038/30918</pub-id> </citation>
</ref>
<ref id="B30">
<label>30.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Baraba&#x301;si</surname>
<given-names>A-L</given-names>
</name>
<name>
<surname>Albert</surname>
<given-names>R</given-names>
</name>
</person-group>. <article-title>Emergence of Scaling in Random Networks</article-title>. <source>Science</source> (<year>1999</year>) <volume>286</volume>:<fpage>509</fpage>&#x2013;<lpage>12</lpage>. <pub-id pub-id-type="doi">10.1126/science.286.5439.509</pub-id> </citation>
</ref>
<ref id="B31">
<label>31.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lancichinetti</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Fortunato</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Radicchi</surname>
<given-names>F</given-names>
</name>
</person-group>. <article-title>Benchmark Graphs for Testing Community Detection Algorithms</article-title>. <source>Phys Rev E</source> (<year>2008</year>) <volume>78</volume>:<fpage>046110</fpage>. <pub-id pub-id-type="doi">10.1103/PhysRevE.78.046110</pub-id> </citation>
</ref>
<ref id="B32">
<label>32.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Girvan</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Newman</surname>
<given-names>MEJ</given-names>
</name>
</person-group>. <article-title>Community Structure in Social and Biological Networks</article-title>. <source>Proc Natl Acad Sci</source> (<year>2002</year>) <volume>99</volume>:<fpage>7821</fpage>&#x2013;<lpage>6</lpage>. <pub-id pub-id-type="doi">10.1073/pnas.122653799</pub-id> </citation>
</ref>
<ref id="B33">
<label>33.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gleiser</surname>
<given-names>PM</given-names>
</name>
<name>
<surname>Danon</surname>
<given-names>L</given-names>
</name>
</person-group>. <article-title>Community Structure in Jazz</article-title>. <source>Advs Complex Syst</source> (<year>2003</year>) <volume>06</volume>:<fpage>565</fpage>&#x2013;<lpage>73</lpage>. <pub-id pub-id-type="doi">10.1142/S0219525903001067</pub-id> </citation>
</ref>
<ref id="B34">
<label>34.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Mastrandrea</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Fournet</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Barrat</surname>
<given-names>A</given-names>
</name>
</person-group>. <article-title>Contact Patterns in a High School: a Comparison between Data Collected Using Wearable Sensors, Contact Diaries and friendship Surveys</article-title>. <source>PLoS One</source> (<year>2015</year>) <volume>10</volume>:<fpage>e0136497</fpage>&#x2013;<lpage>26</lpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0136497</pub-id> </citation>
</ref>
<ref id="B35">
<label>35.</label>
<citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Guimer&#xe0;</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Danon</surname>
<given-names>L</given-names>
</name>
<name>
<surname>D&#xed;az-Guilera</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Giralt</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Arenas</surname>
<given-names>A</given-names>
</name>
</person-group>. <article-title>Self-similar Community Structure in a Network of Human Interactions</article-title>. <source>Phys Rev E</source> (<year>2003</year>) <volume>68</volume>:<fpage>065103</fpage>. <pub-id pub-id-type="doi">10.1103/PhysRevE.68.065103</pub-id> </citation>
</ref>
</ref-list>
</back>
</article>